{ "uniprot_canonical_ac": "A5PLN9-1", "ptm_annotation": [], "sequence": { "header": "sp|A5PLN9-1|TPC13_HUMAN Isoform 1 of Trafficking protein particle complex subunit 13 OS=Homo sapiens OX=9606 GN=TRAPPC13 PE=1 SV=2 CANONICAL=A5PLN9-1", "length": 417, "sequence": "MEVNPPKQEHLLALKVMRLTKPTLFTNIPVTCEEKDLPGDLFNQLMRDDPSTVNGAEVLMLGEMLTLPQNFGNIFLGETFSSYISVHNDSNQVVKDILVKADLQTSSQRLNLSASNAAVAELKPDCCIDDVIHHEVKEIGTHILVCAVSYTTQAGEKMYFRKFFKFQVLKPLDVKTKFYNAESDLSSVTDEVFLEAQIQNMTTSPMFMEKVSLEPSIMYNVTELNSVSQAGECVSTFGSRAYLQPMDTRQYLYCLKPKNEFAEKAGIIKGVTVIGKLDIVWKTNLGERGRLQTSQLQRMAPGYGDVRLSLEAIPDTVNLEEPFHITCKITNCSERTMDLVLEMCNTNSIHWCGISGRQLGKLHPSSSLCLALTLLSSVQGLQSISGLRLTDTFLKRTYEYDDIAQVCVVSSAIKVES" }, "uniprot_id": "TPC13_HUMAN", "glycation": [], "keywords": [ "glycoprotein", "reported_with_glycan.oglcnac_db" ], "species": [ { "common_name": "Human", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5PLN9", "id": "A5PLN9", "database": "UniProtKB" } ], "name": "Homo sapiens", "taxid": 9606 } ], "reaction_enzymes": [], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21453443", "type": "PubMed", "id": "21453443" } ], "title": "Organization and assembly of the TRAPPII complex.", "journal": "Traffic", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5PLN9", "id": "A5PLN9", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001087224.1", "id": "NP_001087224.1", "database": "RefSeq" } ], "authors": "Fang Y., Foster L.J., Schluter C., Conibear E., Choi C., Davey M., Pandher P.", "date": "2011" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23301498", "type": "PubMed", "id": "23301498" } ], "title": "Proteome wide purification and identification of O-GlcNAc-modified proteins using click chemistry and mass spectrometry.", "journal": "Journal of proteome research", "evidence": [ { "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A5PLN9", "id": "A5PLN9", "database": "O-GlcNAc Database" } ], "authors": "Hahne H, Sobotzki N, Nyberg T, Helm D, Borodkin VS, van Aalten DM, Agnew B, Kuster B", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28536105", "type": "PubMed", "id": "28536105" } ], "title": "TRAPPC13 modulates autophagy and the response to Golgi stress.", "journal": "Journal of cell science", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001087224.1", "id": "NP_001087224.1", "database": "RefSeq" } ], "authors": "Ramirez-Peinado S, Ignashkova TI, van Raam BJ, Baumann J, Sennott EL, Gendarme M, Lindemann RK, Starnbach MN, Reiling JH", "date": "2017" } ], "uniprot_ac": "A5PLN9", "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A5PLN9", "type": "recommended", "resource": "UniProtKB", "name": "TRAPPC13" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A5PLN9", "type": "synonym", "resource": "RefSeq", "name": "C5orf44; SHLD3" }, { "url": "https://www.uniprot.org/uniprot/A5PLN9", "type": "synonym", "resource": "UniProtKB", "name": "C5orf44" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A5PLN9", "type": "synonym", "resource": "RefSeq", "name": "TRAPPC13" } ], "reactions": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A5PLN9#A5PLN9-1", "isoform_ac": "A5PLN9-1", "locus": { "end_pos": 65625061, "strand": "-", "start_pos": 65664608, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000399438", "id": "ENST00000399438", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000382367", "id": "ENSP00000382367", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A5PLN9-1|TPC13_HUMAN Isoform 1 of Trafficking protein particle complex subunit 13 OS=Homo sapiens OX=9606 GN=TRAPPC13 PE=1 SV=2 CANONICAL=A5PLN9-1", "length": 417, "sequence": "MEVNPPKQEHLLALKVMRLTKPTLFTNIPVTCEEKDLPGDLFNQLMRDDPSTVNGAEVLMLGEMLTLPQNFGNIFLGETFSSYISVHNDSNQVVKDILVKADLQTSSQRLNLSASNAAVAELKPDCCIDDVIHHEVKEIGTHILVCAVSYTTQAGEKMYFRKFFKFQVLKPLDVKTKFYNAESDLSSVTDEVFLEAQIQNMTTSPMFMEKVSLEPSIMYNVTELNSVSQAGECVSTFGSRAYLQPMDTRQYLYCLKPKNEFAEKAGIIKGVTVIGKLDIVWKTNLGERGRLQTSQLQRMAPGYGDVRLSLEAIPDTVNLEEPFHITCKITNCSERTMDLVLEMCNTNSIHWCGISGRQLGKLHPSSSLCLALTLLSSVQGLQSISGLRLTDTFLKRTYEYDDIAQVCVVSSAIKVES" } }, { "url": "https://www.uniprot.org/uniprot/A5PLN9#A5PLN9-2", "isoform_ac": "A5PLN9-2", "locus": { "end_pos": 65625061, "strand": "-", "start_pos": 65664608, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000231526", "id": "ENST00000231526", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000231526", "id": "ENSP00000231526", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A5PLN9-2|TPC13_HUMAN Isoform 2 of Trafficking protein particle complex subunit 13 OS=Homo sapiens OX=9606 GN=TRAPPC13 PE=1 SV=2 CANONICAL=A5PLN9-1", "length": 411, "sequence": "MEVNPPKQEHLLALKVMRLTKPTLFTNIPVTCEEKDLPGDLFNQLMRDDPSTVNGAEVLMLGEMLTLPQNFGNIFLGETFSSYISVHNDSNQVVKDILVKADLQTSSQRLNLSASNAAVAELKPDCCIDDVIHHEVKEIGTHILVCAVSYTTQAGEKMYFRKFFKFQVLKPLDVKTKFYNAETDEVFLEAQIQNMTTSPMFMEKVSLEPSIMYNVTELNSVSQAGECVSTFGSRAYLQPMDTRQYLYCLKPKNEFAEKAGIIKGVTVIGKLDIVWKTNLGERGRLQTSQLQRMAPGYGDVRLSLEAIPDTVNLEEPFHITCKITNCSERTMDLVLEMCNTNSIHWCGISGRQLGKLHPSSSLCLALTLLSSVQGLQSISGLRLTDTFLKRTYEYDDIAQVCVVSSAIKVES" } }, { "url": "https://www.uniprot.org/uniprot/A5PLN9#A5PLN9-4", "isoform_ac": "A5PLN9-4", "locus": { "end_pos": 65625061, "strand": "-", "start_pos": 65664608, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000505553", "id": "ENST00000505553", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000423405", "id": "ENSP00000423405", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A5PLN9-4|TPC13_HUMAN Isoform 4 of Trafficking protein particle complex subunit 13 OS=Homo sapiens OX=9606 GN=TRAPPC13 PE=1 SV=2 CANONICAL=A5PLN9-1", "length": 412, "sequence": "MEVNPPKQEHLLALKVMRLTKPTLFTNIPVTCEEKDLPGDLFNQLMRDDPSTVNGAEVLMLGEMLTLPQNFGNIFLGETFSSYISVHNDSNQVVKDILVKADLQTSSQRLNLSASNAAVAELKPDCCIDDVIHHEVKEIGTHILVCAVSYTTQAGEKMYFRKFFKFQVLKPLDVKTKFYNAETDEVFLEAQIQNMTTSPMFMEKVSLEPSIMYNVTELNSVSQAGECVSTFGSRAYLQPMDTRQYLYCLKPKNEFAEKAGIIKGVTVIGKLDIVWKTNLGERGRLQTSQLQRMAPGYGDVRLSLEAIPDTVNLEEPFHITCKITNCSSERTMDLVLEMCNTNSIHWCGISGRQLGKLHPSSSLCLALTLLSSVQGLQSISGLRLTDTFLKRTYEYDDIAQVCVVSSAIKVES" } }, { "url": "https://www.uniprot.org/uniprot/A5PLN9#A5PLN9-5", "isoform_ac": "A5PLN9-5", "locus": { "end_pos": 65625061, "strand": "-", "start_pos": 65664608, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000438419", "id": "ENST00000438419", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000409231", "id": "ENSP00000409231", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A5PLN9-5|TPC13_HUMAN Isoform 5 of Trafficking protein particle complex subunit 13 OS=Homo sapiens OX=9606 GN=TRAPPC13 PE=1 SV=2 CANONICAL=A5PLN9-1", "length": 418, "sequence": "MEVNPPKQEHLLALKVMRLTKPTLFTNIPVTCEEKDLPGDLFNQLMRDDPSTVNGAEVLMLGEMLTLPQNFGNIFLGETFSSYISVHNDSNQVVKDILVKADLQTSSQRLNLSASNAAVAELKPDCCIDDVIHHEVKEIGTHILVCAVSYTTQAGEKMYFRKFFKFQVLKPLDVKTKFYNAESDLSSVTDEVFLEAQIQNMTTSPMFMEKVSLEPSIMYNVTELNSVSQAGECVSTFGSRAYLQPMDTRQYLYCLKPKNEFAEKAGIIKGVTVIGKLDIVWKTNLGERGRLQTSQLQRMAPGYGDVRLSLEAIPDTVNLEEPFHITCKITNCSSERTMDLVLEMCNTNSIHWCGISGRQLGKLHPSSSLCLALTLLSSVQGLQSISGLRLTDTFLKRTYEYDDIAQVCVVSSAIKVES" } }, { "url": "https://www.uniprot.org/uniprot/A5PLN9#A5PLN9-7", "isoform_ac": "A5PLN9-7", "locus": {}, "sequence": { "header": "sp|A5PLN9-7|TPC13_HUMAN Isoform 7 of Trafficking protein particle complex subunit 13 OS=Homo sapiens OX=9606 GN=TRAPPC13 PE=1 SV=2 CANONICAL=A5PLN9-1", "length": 309, "sequence": "MEVNPPKQEHLLALKVMRLTKPTLFTNIPVTCEEKDLPGDLFNQLMRDDPSTVNGAEVLMLGEMLTLPQNFGNIFLGETFSSYISVHNDSNQVVKDILVKADLQTSSQRLNLSASNAAVAELKPDCCIDDVIHHEVKEIGTHILVCAVSYTTQAGEKMYFRKFFKFQVLKPLDVKTKFYNAETDEVFLEAQIQNMTTSPMFMEKVSLEPSIMYNVTELNSVSQAGECVSTFGSRAYLQPMDTRQYLYCLKPKNEFAEKAGIIKGVTVIGKLDIVWKTNLGERGRLQTSQLQRMVSLEKTSLGFWCVKDR" } }, { "url": "https://www.uniprot.org/uniprot/A5PLN9#D6RB83-1", "isoform_ac": "D6RB83-1", "locus": { "end_pos": 65625061, "strand": "-", "start_pos": 65647082, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000504751", "id": "ENST00000504751", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000424343", "id": "ENSP00000424343", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D6RB83-1|D6RB83_HUMAN Computationally mapped isoform of Trafficking protein particle complex subunit 13 OS=Homo sapiens OX=9606 GN=TRAPPC13 PE=1 SV=1 CANONICAL=A5PLN9-1", "length": 81, "sequence": "MEVNPPKQEHLLALKVMRLTKPTLFTNIPVTCEEKDLPGDLFNQLMRDDPSTVNGAEVLMLGEMLTLPQNFGLIFRQVLSV" } }, { "url": "https://www.uniprot.org/uniprot/A5PLN9#H0YBF8-1", "isoform_ac": "H0YBF8-1", "locus": { "end_pos": 65635340, "strand": "-", "start_pos": 65647083, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000504243", "id": "ENST00000504243", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000429396", "id": "ENSP00000429396", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|H0YBF8-1|H0YBF8_HUMAN Computationally mapped isoform of Trafficking protein particle complex subunit 13 OS=Homo sapiens OX=9606 GN=TRAPPC13 PE=1 SV=1 CANONICAL=A5PLN9-1", "length": 53, "sequence": "XVTCEEKDLPGDLFNQLMRDDPSTVNGAEVLMLGEMLTLPQNFGLIFRQVLSV" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:80006", "resource": "KEGG Pathway", "id": "hsa:80006", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198", "description": "RAB GEFs exchange GTP for GDP on RABs", "resource": "Reactome", "id": "R-HSA-8876198", "name": "RAB GEFs exchange GTP for GDP on RABs" } ], "reaction_participants": [], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001087224.1", "annotation": "Results lend support for the existence of a mammalian TRAPPIII complex containing TRAPPC13, which is important for autophagic flux under certain stress conditions.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001087224.1", "id": "NP_001087224.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q3TIR1-1", "protein_name": "Trafficking protein particle complex subunit 13", "sequence": { "length": 417, "sequence": "MEVNPPKQEHLLALKVMRLTKPTLFTNIPVTCEEKDLPGDLFNQLMKDDPSTVNGAEILMLGEMLTLPQNFGNIFLGETFSSYISVHNDSNQVVKDILVKADLQTSSQRLNLSASNAAVAELKPDCCIDDVIHHEVKEIGTHILVCAVSYTTQGGEKMYFRKFFKFQVLKPLDVKTKFYNAESDLSSVTDEVFLEAQIQNITTSPMFMEKVSLEPSIMYNVTELNSVTQAGECISTFGSRGYLQPMDTRQYLYCLKPKKEFAEKAGIIKGVTVIGKLDIVWKTNLGERGRLQTSQLQRMAPGYGDVRLSLEAIPDTVNLEEPFHITCKITNCSERMMDLVLEMCNTNSIHWCGISGRQLGKLHPSSSLCLALTLLSSVQGLQSVSGLRLTDTFLKRTYEYDDIAQVCVVSAAVEVEA" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/11792", "id": "11792", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Trappc13", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q5M887-1", "protein_name": "Trafficking protein particle complex subunit 13", "sequence": { "length": 418, "sequence": "MEVNPPKQEHLLALKVMRLTKPTLFTNIPVTCEEKDLPGDLFNQLMKDDPSTVNGAEILMLGEMLTLPQNFGNIFLGETFSSYISVHNDSNQVVKDILVKADLQTSSQRLNLSASNAAVAELKPDCCIDDVIHHEVKEIGTHILVCAVSYTTQGGEKMYFRKFFKFQVLKPLDVKTKFYNAESDLSSVTDEVFLEAQIQNITTSPMFMEKVSLEPSIMYNVTELNSVNQAGECVSTFGSRGYLQPMDTRQYLYCLKPKKEFAEKAGIIKGVTVIGKLDIVWKTNLGERGRLQTSQLQRMAPGYGDVRLSLEAIPDTVNLEEPFHITCKITNCSSERTMDLVLEMCNTTSIHWCGISGRQLGKLHPSSSLCLALTLLSSVQGLQSVSGLRLTDTFLKRTYEYDDIAQVCVVSAAVEVEA" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/11792", "id": "11792", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Trappc13", "tax_id": 10116 } ], "interactions": [], "synthesized_glycans": [], "snv": [ { "comment": "Somatic mutation passed 1 out of 6 filters: patient freq. (1.5%).", "sequence_org": "R", "start_pos": 109, "alt_nt": "T", "chr_id": "5", "subjects_positive": "1", "chr_pos": "64942906", "disease": [ { "disease_id": "DOID:1324", "synonyms": [ { "url": "https://monarchinitiative.org/disease/MONDO:0012159", "resource": "MONDO", "description": "", "name": "LNCR1", "id": "MONDO:0012159" }, { "url": "https://monarchinitiative.org/disease/MONDO:0012159", "resource": "MONDO", "description": "", "name": "lung cancer susceptibility 1", "id": "MONDO:0012159" }, { "url": "https://monarchinitiative.org/disease/MONDO:0012159", "resource": "MONDO", "description": "", "name": "LNCR1", "id": "MONDO:0012159" }, { "url": "https://monarchinitiative.org/disease/MONDO:0012159", "resource": "MONDO", "description": "", "name": "lung cancer susceptibility 1; LNCR1", "id": "MONDO:0012159" }, { "url": "https://monarchinitiative.org/disease/MONDO:0012955", "resource": "MONDO", "description": "", "name": "lung cancer susceptibility 4", "id": "MONDO:0012955" }, { "url": "https://monarchinitiative.org/disease/MONDO:0012955", "resource": "MONDO", "description": "", "name": "lung cancer susceptibility 4; LNCR4", "id": "MONDO:0012955" }, { "url": "https://monarchinitiative.org/disease/MONDO:0012955", "resource": "MONDO", "description": "", "name": "LNCR4", "id": "MONDO:0012955" }, { "url": "https://monarchinitiative.org/disease/MONDO:0012955", "resource": "MONDO", "description": "", "name": "lung cancer susceptibility 4", "id": "MONDO:0012955" }, { "url": "https://monarchinitiative.org/disease/MONDO:0012942", "resource": "MONDO", "description": "", "name": "LNCR3", "id": "MONDO:0012942" }, { "url": "https://monarchinitiative.org/disease/MONDO:0012942", "resource": "MONDO", "description": "", "name": "lung cancer susceptibility 3", "id": "MONDO:0012942" }, { "url": "https://monarchinitiative.org/disease/MONDO:0012942", "resource": "MONDO", "description": "", "name": "LNCR3", "id": "MONDO:0012942" }, { "url": "https://monarchinitiative.org/disease/MONDO:0012942", "resource": "MONDO", "description": "", "name": "adenocarcinoma of lung, susceptibility to", "id": "MONDO:0012942" }, { "url": "https://monarchinitiative.org/disease/MONDO:0012942", "resource": "MONDO", "description": "", "name": "lung cancer susceptibility 3; 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