{
    "uniprot_canonical_ac": "A2AF53-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A2AF53-1|T185A_MOUSE Isoform 1 of Transmembrane protein 185A  OS=Mus musculus OX=10090 GN=Tmem185a PE=1 SV=1 CANONICAL=A2AF53-1", 
        "length": 350, 
        "sequence": "MNLRGLFQDFNPSKFLIYACLLLFSVLLALRLDGIIQWSYWAVFAPIWLWKLMVIVGASVGTGVWARNPQYRAEGETCVEFKAMLIAVGIHLLLLMFEVLVCDRIERGSHFWLLVFMPLFFVSPVSVAACVWGFRHDRSLELEILCSVNILQFIFIALRLDKIIHWPWLVVCVPLWILMSFLCLVVLYYIVWSVLFLRSMDVIAEQRRTHITMALSWMTIVVPLLTFEILLVHKLDGHNAFSCIPIFVPLWLSLITLMATTFGQKGGNHWWFGIRKDFCQFLLEIFPFLREYGNISYDLHHEDSEETEETPVPEPPKIAPMFRKKARVVITQSPGKYVLPPPKLNIEMPD"
    }, 
    "uniprot_id": "Q3TYW3_MOUSE", 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AF53", 
                    "id": "A2AF53", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "reaction_enzymes": [], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/15525354", 
                    "type": "PubMed", 
                    "id": "15525354"
                }
            ], 
            "title": "Cloning of a novel neuronally expressed orphan G-protein-coupled receptor which is up-regulated by erythropoietin, interacts with microtubule-associated protein 1b and colocalizes with the 5-hydroxytryptamine 2a receptor.", 
            "journal": "J. Neurochem.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AF53", 
                    "id": "A2AF53", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028500.1", 
                    "id": "NP_001028500.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Schneider A., Gassler N., Gruenewald S., Kuner T., Rossner M., Weber D., Kuschinsky W., Maurer M.H., Propst F., Wuerz R.", 
            "date": "2004"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/23011808", 
                    "type": "PubMed", 
                    "id": "23011808"
                }
            ], 
            "title": "A major X-linked locus affects kidney function in mice.", 
            "journal": "Molecular genetics and genomics : MGG", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028500.1", 
                    "id": "NP_001028500.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Leduc MS, Savage HS, Stearns TM, Cario CL, Walsh KA, Paigen B, Berndt A", 
            "date": "2012"
        }
    ], 
    "uniprot_ac": "A2AF53", 
    "gene_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A2AF53", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Tmem185a"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AF53", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "BC023829"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AF53", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Ee3"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AF53", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Fam11a"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2AF53", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Tmem185a"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2AF53", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "ee3"
        }
    ], 
    "reactions": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2AF53#A2AF53-1", 
            "isoform_ac": "A2AF53-1", 
            "locus": {
                "end_pos": 70461051, 
                "strand": "+", 
                "start_pos": 70477015, 
                "chromosome": "X", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000114630", 
                        "id": "ENSMUST00000114630", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000110277", 
                        "id": "ENSMUSP00000110277", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2AF53-1|T185A_MOUSE Isoform 1 of Transmembrane protein 185A  OS=Mus musculus OX=10090 GN=Tmem185a PE=1 SV=1 CANONICAL=A2AF53-1", 
                "length": 350, 
                "sequence": "MNLRGLFQDFNPSKFLIYACLLLFSVLLALRLDGIIQWSYWAVFAPIWLWKLMVIVGASVGTGVWARNPQYRAEGETCVEFKAMLIAVGIHLLLLMFEVLVCDRIERGSHFWLLVFMPLFFVSPVSVAACVWGFRHDRSLELEILCSVNILQFIFIALRLDKIIHWPWLVVCVPLWILMSFLCLVVLYYIVWSVLFLRSMDVIAEQRRTHITMALSWMTIVVPLLTFEILLVHKLDGHNAFSCIPIFVPLWLSLITLMATTFGQKGGNHWWFGIRKDFCQFLLEIFPFLREYGNISYDLHHEDSEETEETPVPEPPKIAPMFRKKARVVITQSPGKYVLPPPKLNIEMPD"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AF53#Q3TYW3-1", 
            "isoform_ac": "Q3TYW3-1", 
            "locus": {
                "end_pos": 70461051, 
                "strand": "+", 
                "start_pos": 70477015, 
                "chromosome": "X", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000101506", 
                        "id": "ENSMUST00000101506", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000099043", 
                        "id": "ENSMUSP00000099043", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|Q3TYW3-1|T185A_MOUSE Computationally mapped isoform of Transmembrane protein 185A  OS=Mus musculus OX=10090 GN=Tmem185a PE=1 SV=1 CANONICAL=A2AF53-1", 
                "length": 322, 
                "sequence": "MNLRGLFQDFNPSKFLIYACLLLFSVLLALRLDGIIQWSYWAVFAPIWLWKLMVIVGASVGTGVWARNPQYRAEGETCVEFKAMLIAVGIHLLLLMFEVLVCDRIERGSHFWLLVFMPLFFVSPVSVAACVWGFRHDRSLEVVCVPLWILMSFLCLVVLYYIVWSVLFLRSMDVIAEQRRTHITMALSWMTIVVPLLTFEILLVHKLDGHNAFSCIPIFVPLWLSLITLMATTFGQKGGNHWWFGIRKDFCQFLLEIFPFLREYGNISYDLHHEDSEETEETPVPEPPKIAPMFRKKARVVITQSPGKYVLPPPKLNIEMPD"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:236848", 
            "resource": "KEGG Pathway", 
            "id": "mmu:236848", 
            "name": ""
        }
    ], 
    "reaction_participants": [], 
    "function": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028500.1", 
            "annotation": "The mouse ee3 is an orphan G-protein-coupled receptor with potential connections to erythropoietin and 5HT2a receptor signalling. ee3_2, a similar gene, is also described, along with human orthologs.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028500.1", 
                    "id": "NP_001028500.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "D3ZWX2-1", 
            "protein_name": "Transmembrane protein 185A", 
            "sequence": {
                "length": 350, 
                "sequence": "MNLRGLFQDFNPSKFLIYACLLLFSVLLALRLDGIIQWSYWAVFAPIWLWKLMVIVGASVGTGVWARNPQYRAEGETCVEFKAMLIAVGIHLLLLMFEVLVCDRIERGSHFWLLVFMPLFFVSPVSVAACVWGFRHDRSLELEILCSVNILQFIFIALRLDKIIHWPWLVVCVPLWILMSFLCLVVLYYIVWSVLFLRSMDVIAEQRRTHITMALSWMTIVVPLLTFEILLVHKLDGHNAFSCIPIFVPLWLSLITLMATTFGQKGGNHWWFGIRKDFCQFLLEIFPFLREYGNISYDLHHEDSEETEETPVPEPPKIAPMFRKKARVVITQSPGKYVLPPPKLNIEMPD"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A2AF53/", 
                    "id": "A2AF53", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/66313", 
                    "id": "66313", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Rat", 
            "organism": "Rattus norvegicus", 
            "gene_name": "Tmem185a", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "Q8NFB2-1", 
            "protein_name": "Transmembrane protein 185A", 
            "sequence": {
                "length": 350, 
                "sequence": "MNLRGLFQDFNPSKFLIYACLLLFSVLLALRLDGIIQWSYWAVFAPIWLWKLMVIVGASVGTGVWARNPQYRAEGETCVEFKAMLIAVGIHLLLLMFEVLVCDRIERGSHFWLLVFMPLFFVSPVSVAACVWGFRHDRSLELEILCSVNILQFIFIALRLDKIIHWPWLVVCVPLWILMSFLCLVVLYYIVWSVLFLRSMDVIAEQRRTHITMALSWMTIVVPLLTFEILLVHKLDGHNAFSSIPIFVPLWLSLITLMATTFGQKGGNHWWFGIRKDFCQFLLEIFPFLREYGNISYDLHHEDNEETEETPVPEPPKIAPMFRKKARVVITQSPGKYVLPPPKLNIEMPD"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/66313", 
                    "id": "66313", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "gene_name": "TMEM185A", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb", 
            "label": "Isoforms"
        }, 
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }, 
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028500.1", 
        "ac": "NP_001028500.1", 
        "name": "transmembrane protein 185A isoform 2", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AF53", 
                                "id": "A2AF53", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "integral component of membrane", 
                        "id": "GO:0016021"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", 
                        "pmid": "15525354", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AF53", 
                                "id": "A2AF53", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "dendrite", 
                        "id": "GO:0030425"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 296, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 294
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000073139", 
            "id": "ENSMUSG00000073139", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/236848", 
            "id": "236848", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019396", 
            "id": "IPR019396", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:236848", 
            "id": "mmu:236848", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:2448555", 
            "id": "2448555", 
            "database": "MGI"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/VWAHNPQ/", 
            "id": "VWAHNPQ", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=554512at2759", 
            "id": "554512at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13568", 
            "id": "PTHR13568", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF10269", 
            "id": "PF10269", 
            "database": "Pfam"
        }, 
        {
            "url": "http://purl.obolibrary.org/obo/PR_PR_A2AF53", 
            "id": "PR_A2AF53", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028500", 
            "id": "NP_001028500", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028500.1", 
            "id": "NP_001028500.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006528044", 
            "id": "XP_006528044", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006528044.1", 
            "id": "XP_006528044.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AF53", 
            "id": "A2AF53", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AF53-1", 
            "id": "A2AF53-1", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/Q3TYW3", 
            "id": "Q3TYW3", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/Q3TYW3-1", 
            "id": "Q3TYW3-1", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 40620.0, 
        "chemical_mass": 40620.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2AF53", 
            "name": "Tmem185a", 
            "locus": {
                "end_pos": 70459753, 
                "strand": "-", 
                "start_pos": 70477180, 
                "chromosome": "X", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000073139", 
                        "id": "ENSMUSG00000073139", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A2AF53#names_and_taxonomy", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Transmembrane protein 185A"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AF53#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Erythropoietin-induced EST 3"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AF53#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Protein FAM11A"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AF53#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Transmembrane protein 185A"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2AF53", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "erythropoietin-induced EST 3"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2AF53", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "transmembrane protein 185A isoform 2"
        }
    ]
}