[ { "uniprot_canonical_ac": "Q9NZR2-1", "uniprot_ac": "Q9NZR2", "uniprot_id": "LRP1B_HUMAN", "mass": { "chemical_mass": 515498.0, "monoisotopic_mass": 515498.0 }, "refseq": { "ac": "NP_061027", "name": "low-density lipoprotein receptor-related protein 1B precursor", "summary": "This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reported in several types of cancer. [provided by RefSeq, Jun 2016].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061027" }, "gene_names": [ { "name": "LRP1B", "type": "recommended", "evidence": [ { "id": "Q9NZR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9NZR2" } ] }, { "name": "LRP-1B", "type": "synonym", "evidence": [ { "id": "NP_061027", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061027" } ] }, { "name": "LRP-DIT", "type": "synonym", "evidence": [ { "id": "NP_061027", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061027" } ] }, { "name": "LRP1B", "type": "synonym", "evidence": [ { "id": "NP_061027", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061027" } ] }, { "name": "LRPDIT", "type": "synonym", "evidence": [ { "id": "NP_061027", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061027" }, { "id": "Q9NZR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9NZR2" } ] } ], "protein_names": [ { "name": "Low-density lipoprotein receptor-related protein 1B", "type": "recommended", "evidence": [ { "id": "Q9NZR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9NZR2/entry#names_and_taxonomy" } ] }, { "name": "LRP-1B", "type": "synonym", "evidence": [ { "id": "Q9NZR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9NZR2/entry#names_and_taxonomy" } ] }, { "name": "LRP-DIT", "type": "synonym", "evidence": [ { "id": "Q9NZR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9NZR2/entry#names_and_taxonomy" } ] }, { "name": "LRP-deleted in tumors", "type": "synonym", "evidence": [ { "id": "NP_061027", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061027" } ] }, { "name": "Low-density lipoprotein receptor-related protein-deleted in tumor", "type": "synonym", "evidence": [ { "id": "Q9NZR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9NZR2/entry#names_and_taxonomy" } ] }, { "name": "low density lipoprotein receptor related protein-deleted in tumor", "type": "synonym", "evidence": [ { "id": "NP_061027", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061027" } ] }, { "name": "low density lipoprotein receptor-related protein 1B", "type": "synonym", "evidence": [ { "id": "NP_061027", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061027" } ] }, { "name": "low density lipoprotein-related protein 1B (deleted in tumors)", "type": "synonym", "evidence": [ { "id": "NP_061027", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061027" } ] }, { "name": "low-density lipoprotein receptor-related protein 1B precursor", "type": "synonym", "evidence": [ { "id": "NP_061027", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061027" } ] } ], "function": [ { "annotation": "Antitumor immunity and prognosis value elicited by FAT3 and LRP1B co-mutation in endometrial cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_061027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061027" }, { "database": "PubMed", "id": "38696842", "url": "https://glygen.org/publication/PubMed/38696842" } ] }, { "annotation": "LDL Receptor-Related Protein 1B Polymorphisms Associated with Increased Risk of Lymph Node Metastasis in Oral Cancer Group with Diabetes Mellitus. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_061027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061027" }, { "database": "PubMed", "id": "38612772", "url": "https://glygen.org/publication/PubMed/38612772" } ] }, { "annotation": "LRP1B can function as a negative regulator of uPAR regeneration and cell migration.", "evidence": [ { "database": "RefSeq", "id": "NP_061027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061027" }, { "database": "PubMed", "id": "12194987", "url": "https://glygen.org/publication/PubMed/12194987" } ] }, { "annotation": "LRP1B-a prognostic marker in tubo-ovarian high-grade serous carcinoma.", "evidence": [ { "database": "RefSeq", "id": "NP_061027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061027" }, { "database": "PubMed", "id": "37742945", "url": "https://glygen.org/publication/PubMed/37742945" } ] }, { "annotation": "Loss of LRP1B expression drives acquired chemo and radio-resistance in HPV-positive head and neck cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_061027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061027" }, { "database": "PubMed", "id": "37778229", "url": "https://glygen.org/publication/PubMed/37778229" } ] }, { "annotation": "Loss of LRP1B function in esophageal carcinogenesis most often occurs either by homozygous deletion or by transcriptional silencing through hypermethylation of its CpG island.", "evidence": [ { "database": "RefSeq", "id": "NP_061027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061027" }, { "database": "PubMed", "id": "15172977", "url": "https://glygen.org/publication/PubMed/15172977" } ] }, { "annotation": "Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis.", "evidence": [ { "database": "UniProtKB", "id": "Q9NZR2", "url": "https://www.uniprot.org/uniprotkb/Q9NZR2#function" } ] }, { "annotation": "The LRP1B gene is a candidate tumor suppressor gene in urothelial cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_061027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061027" }, { "database": "PubMed", "id": "12004004", "url": "https://glygen.org/publication/PubMed/12004004" } ] }, { "annotation": "This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reported in several types of cancer. [provided by RefSeq, Jun 2016].", "evidence": [ { "database": "RefSeq", "id": "NP_061027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061027" } ] } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": 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"MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": 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"MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ], "unlinked_id_list": [ "DOID:4765" ], "evidence": [ { "id": "1324", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1324" } ] }, { "disease_id": "DOID:1826", "recommended_name": { "id": "DOID:1826", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1826", "name": "epilepsy", "description": "A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions." }, "synonyms": [ { "id": "DOID:1826", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1826", "name": "epilepsy syndrome", "description": "" }, { "id": "DOID:1826", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1826", "name": "epileptic syndrome", "description": "" } ], "unlinked_id_list": [ "DOID:3331", "DOID:0050702", "DOID:0060172", "DOID:0050706", "DOID:0050705", "DOID:0050703", "DOID:0050701", "DOID:0060169" ], "evidence": [ { "id": "1826", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1826" } ] }, { "disease_id": "DOID:1909", "recommended_name": { "id": "DOID:1909", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1909", "name": "melanoma", "description": "A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from melanocytes which are found in skin, the bowel and the eye." }, "synonyms": [ { "id": "DOID:1909", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1909", "name": "Naevocarcinoma", "description": "" }, { "id": "DOID:1909", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1909", "name": "malignant melanoma", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "1909", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1909" } ] }, { "disease_id": "DOID:219", "recommended_name": { "id": "DOID:219", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:219", "name": "colon cancer", "description": "A colorectal cancer that is located_in the colon." }, "synonyms": [], "unlinked_id_list": [], "evidence": [ { "id": "219", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:219" } ] }, { "disease_id": "DOID:3083", "recommended_name": { "id": "DOID:3083", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3083", "name": "chronic obstructive pulmonary disease", "description": "An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both." }, "synonyms": [ { "id": "DOID:3083", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3083", "name": "COLD", "description": "" }, { "id": "DOID:3083", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3083", "name": "COPD", "description": "" }, { "id": "DOID:3083", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3083", "name": "chronic obstructive airway disease", "description": "" }, { "id": "DOID:3083", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3083", "name": "chronic obstructive lung disease", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "chronic obstructive pulmonary disease", "description": "A chronic and progressive lung disorder characterized by the loss of elasticity of the bronchial tree and the air sacs, destruction of the air sacs wall, thickening of the bronchial wall, and mucous accumulation in the bronchial tree. The pathologic changes result in the disruption of the air flow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough, and chest tightness. The two main types of chronic obstructive pulmonary disease are chronic obstructive bronchitis and emphysema." }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "COLD", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "COPD", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "COPD, chronic obstructive pulmonary disease", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "chronic obstructive airways disease", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "chronic obstructive lung disease", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "chronic obstructive pulmonary disease (COPD)", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "chronic obstructive pulmonary disease, (COPD)", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "cold", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "cold (chronic obstructive lung disease)", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "disease (COPD), chronic obstructive", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "obstructive lung disease, chronic", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "obstructive pulmonary disease (COPD), chronic", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "pulmonary disease (COPD), chronic obstructive", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "3083", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3083" } ] }, { "disease_id": "DOID:3121", "recommended_name": { "id": "DOID:3121", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3121", "name": "gallbladder cancer", "description": "A biliary tract cancer that is located_in the gallbladder." }, "synonyms": [ { "id": "DOID:3121", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3121", "name": "gallbladder Ca", "description": "" }, { "id": "DOID:3121", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3121", "name": "gallbladder neoplasm", "description": "" }, { "id": "DOID:3121", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3121", "name": "localized malignant gallbladder neoplasm", "description": "" }, { "id": "DOID:3121", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3121", "name": "malignant neoplasm of gallbladder", "description": "" }, { "id": "DOID:3121", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3121", "name": "malignant tumor of the gallbladder", "description": "" }, { "id": "DOID:3121", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3121", "name": "malignant tumour of gallbladder", "description": "" }, { "id": "DOID:3121", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3121", "name": "tumor of the gallbladder", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "3121", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3121" } ] }, { "disease_id": "DOID:3908", "recommended_name": { "id": "DOID:3908", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3908", "name": "lung non-small cell carcinoma", "description": "A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma." }, "synonyms": [ { "id": "DOID:3908", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3908", "name": "NSCLC", "description": "" }, { "id": "DOID:3908", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3908", "name": "Non-small cell lung cancer", "description": "" }, { "id": "DOID:3908", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3908", "name": "non-small cell lung carcinoma", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "3908", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3908" } ] }, { "disease_id": "DOID:3910", "recommended_name": { "id": "DOID:3910", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3910", "name": "lung adenocarcinoma", "description": "A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin." }, "synonyms": [ { "id": "DOID:3910", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3910", "name": "bronchogenic lung adenocarcinoma", "description": "" }, { "id": "DOID:3910", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3910", "name": "nonsmall cell adenocarcinoma", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "3910", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3910" } ] }, { "disease_id": "DOID:4928", "recommended_name": { "id": "DOID:4928", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4928", "name": "intrahepatic cholangiocarcinoma", "description": "A cholangiocarcinoma that arises from the intrahepatic bile duct epithelium in any site of the intrahepatic biliary tree." }, "synonyms": [ { "id": "DOID:4928", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4928", "name": "Intrahepatic bile duct carcinoma", "description": "" }, { "id": "DOID:4928", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4928", "name": "peripheral Cholangiocarcinoma", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "4928", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4928" } ] }, { "disease_id": "DOID:684", "recommended_name": { "id": "DOID:684", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:684", "name": "hepatocellular carcinoma", "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver." }, "synonyms": [ { "id": "DOID:684", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:684", "name": "Hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation." }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "HCC", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "cancer, hepatocellular", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma, hepatocellular, malignant", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular adenocarcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, childhood type, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell cancer (hepatocellular carcinoma)", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult primary hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation." }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "HCC", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "cancer, hepatocellular", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma, hepatocellular, malignant", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular adenocarcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, childhood type, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell cancer (hepatocellular carcinoma)", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult primary hepatocellular carcinoma", "description": "" }, { "id": "MIM:114550", "resource": "MIM", "url": "https://www.omim.org/entry/114550", "name": "Hepatocellular carcinoma", "description": "Hepatocellular carcinoma" } ], "unlinked_id_list": [], "evidence": [ { "id": "684", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:684" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": 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"disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": 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"MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": 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"MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "Q9NZR2", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q9NZR2" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] } ] }, { "significant": "No", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "Q9NZR2", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q9NZR2" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant 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"https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant 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"MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": 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Classification" ] }, { "id": "E7ERG8", "url": "https://www.orthodb.org/?gene=E7ERG8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "H0Y7T7", "url": "https://www.orthodb.org/?gene=H0Y7T7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "H7C0A8", "url": "https://www.orthodb.org/?gene=H7C0A8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q9NZR2", "url": "https://www.orthodb.org/?gene=Q9NZR2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22722", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22722", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22722:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22722:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24033", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24033", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24033:SF151", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24033:SF151", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00008", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00008", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF00057", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00057", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF00058", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00058", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF07645", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07645", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF12662", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12662", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF14670", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14670", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "Q9NZR2", "url": "https://pharos.nih.gov/targets/Q9NZR2", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR:Q9NZR2", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:Q9NZR2", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_061027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061027", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "GLY_000040", "url": "http://data.glygen.org/GLY_000040", "database": "UniCarbKB", "categories": [] }, { "id": "E7ERG8", "url": "https://www.uniprot.org/uniprotkb/E7ERG8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E7ERG8-1", "url": "https://www.uniprot.org/uniprotkb/E7ERG8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0Y7T7", "url": "https://www.uniprot.org/uniprotkb/H0Y7T7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0Y7T7-1", "url": "https://www.uniprot.org/uniprotkb/H0Y7T7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H7C0A8", "url": "https://www.uniprot.org/uniprotkb/H7C0A8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H7C0A8-1", "url": "https://www.uniprot.org/uniprotkb/H7C0A8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9NZR2", "url": "https://www.uniprot.org/uniprotkb/Q9NZR2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9NZR2-1", "url": "https://www.uniprot.org/uniprotkb/Q9NZR2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSEFLLALLTLSGLLPIARVLTVGADRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGSKMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIKIENAWGIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRPKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMNGSIFQLDLITSEVTLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCDECSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACPHLMKLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSIIHGIDKPQCLAAHPVRGKLYWTDGNTINMANMDGSNSKILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMDALMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGGCKQLCLYRGNSRRTCACAHGYLAEDGVTCLRHEGYLLYSGRTILKSIHLSDETNLNSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNIQLIKDNWEDRQVIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPHQPMGIIAVANDTNSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNAYSEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDGRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHINECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADENHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKCVCDQNFQERNNTCIAEGSEDQVLYIANDTDILGFIYPFNYSGDHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKNGVFRVQKFGHGSVEYLALNIDKTKGVLISHRYKQLDLPNPCLDLACEFLCLLNPSGATCVCPEGKYLINGTCNDDSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSYSGERCEVNHCSNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVCEDFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCTIGDDGSVECVCPTRYEGPKCEVDKCVRCHGGHCIINKDSEDIFCNCTNGKIASSCQLCDGYCYNGGTCQLDPETNVPVCLCSTNWSGTQCERPAPKSSKSDHISTRSIAIIVPLVLLVTLITTLVIGLVLCKRKRRTKTIRRQPIINGGINVEIGNPSYNMYEVDHDHNDGGLLDPGFMIDPTKARYIGGGPSAFKLPHTAPPIYLNSDLKGPLTAGPTNYSNPVYAKLYMDGQNCRNSLGSVDERKELLPKKIEIGIRETVA", "length": 4599, "header": "sp|Q9NZR2-1|LRP1B_HUMAN Isoform 1 of Low-density lipoprotein receptor-related protein 1B OS=Homo sapiens OX=9606 GN=LRP1B PE=1 SV=2 CANONICAL=Q9NZR2-1" }, "isoforms": [ { "isoform_ac": "E7ERG8-1", "url": "https://www.uniprot.org/uniprotkb/Q9NZR2/entry#E7ERG8-1", "sequence": { "sequence": "MSEFLLALLTLSGLLPIARVLTVGADRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTSRTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCDECSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACPHLMKLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFIN", "length": 781, "header": "tr|E7ERG8-1|E7ERG8_HUMAN Computationally mapped isoform of LDL receptor related protein 1B OS=Homo sapiens OX=9606 GN=LRP1B PE=1 SV=8 CANONICAL=Q9NZR2-1" }, "locus": { "chromosome": "2", "start_pos": 142130729, "end_pos": 140850133, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000434794.1", "url": "https://www.ensembl.org/id/ENST00000434794.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000413239.1", "url": "https://www.ensembl.org/id/ENSP00000413239.1" } ] } }, { "isoform_ac": "H0Y7T7-1", "url": "https://www.uniprot.org/uniprotkb/Q9NZR2/entry#H0Y7T7-1", "sequence": { "sequence": "XSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKCVCDQNFQERNNTCIAEGSEDQVLYIANDTDILGFIYPFNYSGDHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKNGVFRVQKFGHGSVEYLALNIDKTKGVLISHRYKQLDLPNPCLDLACEFLCLLNPSGATCVCPEGKYLINGTCNDDSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSYSGERCEVNHCSNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVCEDFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCTIGDDGSVECVCPTRYEGPKCEVDKCVRCHGGHCIINKDSEDIFCNCTNGKIASSCQLCDGYCYNGGTCQLDPETNVPVCLCSTNWSGTQCERPAPKSSKSDHISTRSIAIIVPLVLLVTLITTLVIGLVLCKRKRRTKTIRRQPIINGGINVEIGNPSYNMYEVDHDHNDGGLLDPGFMIDPTKPTNYSNPVYAKLYMDGQNCRNSLGSVDERKELLPKKIEIGIRETVA", "length": 798, "header": "tr|H0Y7T7-1|LRP1B_HUMAN Computationally mapped isoform of Low-density lipoprotein receptor-related protein 1B OS=Homo sapiens OX=9606 GN=LRP1B PE=1 SV=1 CANONICAL=Q9NZR2-1" }, "locus": { "chromosome": "2", "start_pos": 140358068, "end_pos": 140233188, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000437977.5", "url": "https://www.ensembl.org/id/ENST00000437977.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000415052.1", "url": "https://www.ensembl.org/id/ENSP00000415052.1" } ] } }, { "isoform_ac": "H7C0A8-1", "url": "https://www.uniprot.org/uniprotkb/Q9NZR2/entry#H7C0A8-1", "sequence": { "sequence": "XRPTCSCALGFTGPNCGKTVCEDFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCTIGDDGSVECVCPTRYEGPKCEVDKCVRCHGGHCIINKDSEDIFCNCTNGKIASSCQLCDGYCYNGGTCQLDPETNVPVCLCSVGFKSQRCDQKENPCDHYCQNEGICTLTAFNEPRCKCSTNWSGTQCERPAPKSSKSDHISTRSIAIIVPLVLLVTLITTLVIGLVLCKRKRRTKTIRRQPIINGGINVEIGNPSYNMYEVDHDHNDGGLL", "length": 280, "header": "tr|H7C0A8-1|LRP1B_HUMAN Computationally mapped isoform of Low-density lipoprotein receptor-related protein 1B OS=Homo sapiens OX=9606 GN=LRP1B PE=1 SV=1 CANONICAL=Q9NZR2-1" }, "locus": { "chromosome": "2", "start_pos": 140297969, "end_pos": 140238182, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000442974.1", "url": "https://www.ensembl.org/id/ENST00000442974.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000393859.1", "url": "https://www.ensembl.org/id/ENSP00000393859.1" } ] } }, { "isoform_ac": "Q9NZR2-1", "url": "https://www.uniprot.org/uniprotkb/Q9NZR2/entry#Q9NZR2-1", "sequence": { "sequence": "MSEFLLALLTLSGLLPIARVLTVGADRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGSKMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIKIENAWGIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRPKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMNGSIFQLDLITSEVTLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCDECSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACPHLMKLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSIIHGIDKPQCLAAHPVRGKLYWTDGNTINMANMDGSNSKILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMDALMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGGCKQLCLYRGNSRRTCACAHGYLAEDGVTCLRHEGYLLYSGRTILKSIHLSDETNLNSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNIQLIKDNWEDRQVIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPHQPMGIIAVANDTNSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNAYSEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDGRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHINECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADENHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKCVCDQNFQERNNTCIAEGSEDQVLYIANDTDILGFIYPFNYSGDHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKNGVFRVQKFGHGSVEYLALNIDKTKGVLISHRYKQLDLPNPCLDLACEFLCLLNPSGATCVCPEGKYLINGTCNDDSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSYSGERCEVNHCSNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVCEDFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCTIGDDGSVECVCPTRYEGPKCEVDKCVRCHGGHCIINKDSEDIFCNCTNGKIASSCQLCDGYCYNGGTCQLDPETNVPVCLCSTNWSGTQCERPAPKSSKSDHISTRSIAIIVPLVLLVTLITTLVIGLVLCKRKRRTKTIRRQPIINGGINVEIGNPSYNMYEVDHDHNDGGLLDPGFMIDPTKARYIGGGPSAFKLPHTAPPIYLNSDLKGPLTAGPTNYSNPVYAKLYMDGQNCRNSLGSVDERKELLPKKIEIGIRETVA", "length": 4599, "header": "sp|Q9NZR2-1|LRP1B_HUMAN Isoform 1 of Low-density lipoprotein receptor-related protein 1B OS=Homo sapiens OX=9606 GN=LRP1B PE=1 SV=2 CANONICAL=Q9NZR2-1" }, "locus": { "chromosome": "2", "start_pos": 142130729, "end_pos": 140233189, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000389484.8", "url": "https://www.ensembl.org/id/ENST00000389484.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000374135.3", "url": "https://www.ensembl.org/id/ENSP00000374135.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 1041, "start_aa": "Asn", "end_pos": 1041, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1041", "evidence": [ { "id": "Q9NZR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9NZR2#ptm_processing" } ], "filter_code": "00100000000000000000.00010000000000.0.01001" }, { "glytoucan_ac": "G80920RR", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "CDGEKDCEDGSDEKGCNGTIR", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1089, "start_aa": "Asn", "end_pos": 1089, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1089", "evidence": [ { "id": "10.1101/2023.09.13.557529", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "id": "GLY_000888", "database": "Data Submission", "url": "http://data.glygen.org/GLY_000888" } ], "filter_code": "00100000000000000000.0000000.00010000000000.0100000.1100000000.110111110111111110.00010.01001" }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "reported", "site_category_dict": { "reported": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 1089, "start_aa": "Asn", "end_pos": 1089, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1089", "evidence": [ { "id": "Q9NZR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9NZR2#ptm_processing" } ], "filter_code": "00100000000000000000.00010000000000.00.01001" }, { "glytoucan_ac": "G80920RR", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "HPCANDTSVCLQPEK", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1145, "start_aa": "Asn", "end_pos": 1145, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1145", "evidence": [ { "id": "10.1101/2023.09.13.557529", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "id": "GLY_000888", "database": "Data Submission", "url": "http://data.glygen.org/GLY_000888" } ], "filter_code": "00100000000000000000.0000000.00010000000000.0100000.1100000000.110111110111111110.00010.01001" }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "reported", "site_category_dict": { "reported": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 1145, "start_aa": "Asn", "end_pos": 1145, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1145", "evidence": [ { "id": "Q9NZR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9NZR2#ptm_processing" } ], "filter_code": "00100000000000000000.00010000000000.00.01001" }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 1209, "start_aa": "Asn", "end_pos": 1209, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1209", "evidence": [ { "id": "Q9NZR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9NZR2#ptm_processing" } ], "filter_code": "00100000000000000000.00010000000000.0.01001" }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 1298, "start_aa": "Asn", "end_pos": 1298, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1298", "evidence": [ { "id": "Q9NZR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9NZR2#ptm_processing" } ], "filter_code": "00100000000000000000.00010000000000.0.01001" }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 134, "start_aa": "Asn", "end_pos": 134, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn134", "evidence": [ { "id": "Q9NZR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9NZR2#ptm_processing" } ], "filter_code": "00100000000000000000.00010000000000.0.01001" }, { "glytoucan_ac": "G41247ZX", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "WTGQNVSVIQK", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1502, "start_aa": "Asn", "end_pos": 1502, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1502", "evidence": [ { "id": "10.1101/2023.09.13.557529", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "id": "GLY_000888", "database": "Data Submission", "url": "http://data.glygen.org/GLY_000888" } ], "filter_code": "00100000000000000000.0000000.00010000000000.0100000.1100000000.111111110111111110.00010.01001" }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "reported", "site_category_dict": { "reported": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 1502, "start_aa": "Asn", "end_pos": 1502, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1502", "evidence": [ { "id": "Q9NZR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9NZR2#ptm_processing" } ], "filter_code": "00100000000000000000.00010000000000.00.01001" }, { "glytoucan_ac": "G80920RR", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "GPCSHMCLINHNR", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1549, "start_aa": "Asn", "end_pos": 1549, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1549", "evidence": [ { "id": "10.1101/2023.09.13.557529", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "id": "GLY_000888", "database": "Data Submission", "url": "http://data.glygen.org/GLY_000888" } ], "filter_code": "00100000000000000000.0000000.00010000000000.0100000.1100000000.110111110111111110.00010.01001" }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "reported", "site_category_dict": { "reported": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 1549, "start_aa": "Asn", "end_pos": 1549, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1549", "evidence": [ { "id": "Q9NZR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9NZR2#ptm_processing" } ], "filter_code": "00100000000000000000.00010000000000.00.01001" }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_pos": 1582, "start_aa": "Ser", "end_pos": 1582, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser1582", "evidence": [ { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" }, { "id": "Q9NZR2", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NZR2" } ], "filter_code": "00000000000000010000.0000000.00000001000000.1000000.0100000000.110100100001111011.10000.01001" }, { "glytoucan_ac": "G80920RR", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "AFINGTGLETVISR", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1636, "start_aa": "Asn", "end_pos": 1636, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1636", "evidence": [ { "id": "10.1101/2023.09.13.557529", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "id": "GLY_000888", "database": "Data Submission", "url": "http://data.glygen.org/GLY_000888" } ], "filter_code": "00100000000000000000.0000000.00010000000000.0100000.1100000000.110111110111111110.00010.01001" }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "reported", "site_category_dict": { 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"glycoprotein_reported", "glycoprotein_predicted" ], "publication": [ { "title": "Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology", "journal": "EMBO J", "date": "2013", "authors": "Steentoft C., Vakhrushev S.Y., Joshi H.J., Kong Y., Vester-Christensen M.B., Schjoldager K.T., Lavrsen K., Dabelsteen S., Pedersen N.B., Marcos-Silva L., Gupta R., Bennett E.P., Mandel U., Brunak S., Wandall H.H., Levery S.B., Clausen H.", "evidence": [ { "database": "UniCarbKB", "id": "GLY_000040", "url": "http://data.glygen.org/GLY_000040" } ], "reference": [ { "type": "DOI", "id": "10.1038/emboj.2013.79", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "title": "Deep quantitative glycoproteomics reveals gut microbiome induced remodeling of the brain glycoproteome", "journal": "bioRxiv", "date": "2023", "authors": "Potel C.M., Burtscher M.L., Garrido-Rodriguez M., Brauer-Nikonow A., Becher I., Typas A., Zimmermann M., Savitski M.", "evidence": 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RK, Hillier LW, McPherson JD, Marra MA, Mardis ER, Fulton LA, Chinwalla AT, Pepin KH, Gish WR, Chissoe SL, Wendl MC, Delehaunty KD, Miner TL, Delehaunty A, Kramer JB, Cook LL, Fulton RS, Johnson DL, Minx PJ, Clifton SW, Hawkins T, Branscomb E, Predki P, Richardson P, Wenning S, Slezak T, Doggett N, Cheng JF, Olsen A, Lucas S, Elkin C, Uberbacher E, Frazier M, Gibbs RA, Muzny DM, Scherer SE, Bouck JB, Sodergren EJ, Worley KC, Rives CM, Gorrell JH, Metzker ML, Naylor SL, Kucherlapati RS, Nelson DL, Weinstock GM, Sakaki Y, Fujiyama A, Hattori M, Yada T, Toyoda A, Itoh T, Kawagoe C, Watanabe H, Totoki Y, Taylor T, Weissenbach J, Heilig R, Saurin W, Artiguenave F, Brottier P, Bruls T, Pelletier E, Robert C, Wincker P, Smith DR, Doucette-Stamm L, Rubenfield M, Weinstock K, Lee HM, Dubois J, Rosenthal A, Platzer M, Nyakatura G, Taudien S, Rump A, Yang H, Yu J, Wang J, Huang G, Gu J, Hood L, Rowen L, Madan A, Qin S, Davis RW, Federspiel NA, Abola AP, Proctor MJ, Myers RM, Schmutz J, Dickson M, Grimwood J, Cox DR, Olson MV, Kaul R, Raymond C, Shimizu N, Kawasaki K, Minoshima S, Evans GA, Athanasiou M, Schultz R, Roe BA, Chen F, Pan H, Ramser J, Lehrach H, Reinhardt R, McCombie WR, de la Bastide M, Dedhia N, Blocker H, Hornischer K, Nordsiek G, Agarwala R, Aravind L, Bailey JA, Bateman A, Batzoglou S, Birney E, Bork P, Brown DG, Burge CB, Cerutti L, Chen HC, Church D, Clamp M, Copley RR, Doerks T, Eddy SR, Eichler EE, Furey TS, Galagan J, Gilbert JG, Harmon C, Hayashizaki Y, Haussler D, Hermjakob H, Hokamp K, Jang W, Johnson LS, Jones TA, Kasif S, Kaspryzk A, Kennedy S, Kent WJ, Kitts P, Koonin EV, Korf I, Kulp D, Lancet D, Lowe TM, McLysaght A, Mikkelsen T, Moran JV, Mulder N, Pollara VJ, Ponting CP, Schuler G, Schultz J, Slater G, Smit AF, Stupka E, Szustakowki J, Thierry-Mieg D, Thierry-Mieg J, Wagner L, Wallis J, Wheeler R, Williams A, Wolf YI, Wolfe KH, Yang SP, Yeh RF, Collins F, Guyer MS, Peterson J, Felsenfeld A, Wetterstrand KA, Patrinos A, Morgan MJ, de Jong P, Catanese JJ, Osoegawa K, Shizuya H, Choi S, Chen YJ, Szustakowki J", "evidence": [ { "database": "UniProtKB", "id": "H0Y7T7", "url": "https://www.uniprot.org/uniprotkb/H0Y7T7" } ], "reference": [ { "type": "PubMed", "id": "11237011", "url": "https://glygen.org/publication/PubMed/11237011" } ] }, { "title": "The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein.", "journal": "J. Biol. Chem.", "date": "2001", "authors": "Liu CX, Li Y, Obermoeller-McCormick LM, Schwartz AL, Bu G", "evidence": [ { "database": "UniProtKB", "id": "Q9NZR2", "url": "https://www.uniprot.org/uniprotkb/Q9NZR2" } ], "reference": [ { "type": "PubMed", "id": "11384978", "url": "https://glygen.org/publication/PubMed/11384978" } ] }, { "title": "Alteration of the LRP1B gene region is associated with high grade of urothelial cancer.", "journal": "Laboratory investigation; a journal of technical methods and pathology", "date": "2002", "authors": "Langbein S, Szakacs O, Wilhelm M, Sukosd F, Weber S, Jauch A, Lopez Beltran A, Alken P, Kalble T, Kovacs G", "evidence": [ { "database": "RefSeq", "id": "NP_061027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061027" } ], "reference": [ { "type": "PubMed", "id": "12004004", "url": "https://glygen.org/publication/PubMed/12004004" } ] }, { "title": "Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Li Y, Knisely JM, Lu W, McCormick LM, Wang J, Henkin J, Schwartz AL, Bu G", "evidence": [ { "database": "RefSeq", "id": "NP_061027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061027" } ], "reference": [ { "type": "PubMed", "id": "12194987", "url": "https://glygen.org/publication/PubMed/12194987" } ] }, { "title": "Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma.", "journal": "Cancer research", "date": "2004", "authors": "Sonoda I, Imoto I, Inoue J, Shibata T, Shimada Y, Chin K, Imamura M, Amagasa T, Gray JW, Hirohashi S, Inazawa J", "evidence": [ { "database": "RefSeq", "id": "NP_061027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061027" } ], "reference": [ { "type": "PubMed", "id": "15172977", "url": "https://glygen.org/publication/PubMed/15172977" } ] }, { "title": "Motif-specific sampling of phosphoproteomes.", "journal": "Journal of proteome research", "date": "2008", "authors": "Ruse CI, McClatchy DB, Lu B, Cociorva D, Motoyama A, Park SK, Yates JR 3rd", "evidence": [ { "database": "iPTMnet", "id": "Q9NZR2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NZR2" } ], "reference": [ { "type": "PubMed", "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278" } ] }, { "title": "Phosphoproteomic analysis of human embryonic stem cells.", "journal": "Cell stem cell", "date": "2009", "authors": "Brill LM, Xiong W, Lee KB, Ficarro SB, Crain A, Xu Y, Terskikh A, Snyder EY, Ding S", "evidence": [ { "database": "iPTMnet", "id": "Q9NZR2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NZR2" } ], "reference": [ { "type": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" } ] }, { "title": "Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology.", "journal": "The EMBO journal", "date": "2013", "authors": "Steentoft C, Vakhrushev SY, Joshi HJ, Kong Y, Vester-Christensen MB, Schjoldager KT, Lavrsen K, Dabelsteen S, Pedersen NB, Marcos-Silva L, Gupta R, Bennett EP, Mandel U, Brunak S, Wandall HH, Levery SB, Clausen H", "evidence": [ { "database": "UniCarbKB", "id": "GLY_000040", "url": "http://data.glygen.org/GLY_000040" } ], "reference": [ { "type": "PubMed", "id": "23584533", "url": "https://glygen.org/publication/PubMed/23584533" } ] }, { "title": "The nature and extent of contributions by defective ribosome products to the HLA peptidome.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2014-04-22", "authors": "Bourdetsky Dmitry, Schmelzer Christian E H, Admon Arie", "evidence": [ { "database": "IEDB", "id": "505973", "url": "https://www.iedb.org/epitope/505973" } ], "reference": [ { "type": "PubMed", "id": "24715725", "url": "https://glygen.org/publication/PubMed/24715725" } ] }, { "title": "Viral infection causes a shift in the self peptide repertoire presented by human MHC class I molecules.", "journal": "Proteomics. Clinical applications", "date": "2015-12", "authors": "Spencer Charles T, Bezbradica Jelena S, Ramos Mireya G, Arico Chenoa D, Conant Stephanie B, Gilchuk Pavlo, Gray Jennifer J, Zheng Mu, Niu Xinnan, Hildebrand William, Link Andrew J, Joyce Sebastian", "evidence": [ { "database": "IEDB", "id": "496721", "url": "https://www.iedb.org/epitope/496721" } ], "reference": [ { "type": "PubMed", "id": "26768311", "url": "https://glygen.org/publication/PubMed/26768311" } ] }, { "title": "Mass spectrometric analysis of the HLA class I peptidome of melanoma cell lines as a promising tool for the identification of putative tumor-associated HLA epitopes.", "journal": "Cancer immunology, immunotherapy : CII", "date": "2016-11", "authors": "Gloger Andreas, Ritz Danilo, Fugmann Tim, Neri Dario", "evidence": [ { "database": "IEDB", "id": "565810", "url": "https://www.iedb.org/epitope/565810" } ], "reference": [ { "type": "PubMed", "id": "27600516", "url": 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HLA-A*29:02 and Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) with Birdshot Chorioretinopathy.", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Sanz-Bravo A, Martin-Esteban A, Kuiper JJW, Garcia-Peydro M, Barnea E, Admon A, Lopez de Castro JA", "evidence": [ { "database": "IEDB", "id": "839992", "url": "https://www.iedb.org/epitope/839992" } ], "reference": [ { "type": "PubMed", "id": "29769354", "url": "https://glygen.org/publication/PubMed/29769354" } ] }, { "title": "HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome.", "journal": "Nature communications", "date": "2018-11-08", "authors": "Illing Patricia T, Pymm Phillip, Croft Nathan P, Hilton Hugo G, Jojic Vladimir, Han Alex S, Mendoza Juan L, Mifsud Nicole A, Dudek Nadine L, McCluskey James, Parham Peter, Rossjohn Jamie, Vivian Julian P, Purcell Anthony W", "evidence": [ { "database": "IEDB", "id": "603834", "url": "https://www.iedb.org/epitope/603834" 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"type": "PubMed", "id": "30429286", "url": "https://glygen.org/publication/PubMed/30429286" } ] }, { "title": "Specific MHC-I Peptides Are Induced Using PROTACs.", "journal": "Frontiers in immunology", "date": "2018", "authors": "Jensen Stephanie M, Potts Gregory K, Ready Damien B, Patterson Melanie J", "evidence": [ { "database": "IEDB", "id": "866418", "url": "https://www.iedb.org/epitope/866418" }, { "database": "IEDB", "id": "866807", "url": "https://www.iedb.org/epitope/866807" }, { "database": "IEDB", "id": "868437", "url": "https://www.iedb.org/epitope/868437" } ], "reference": [ { "type": "PubMed", "id": "30524438", "url": "https://glygen.org/publication/PubMed/30524438" } ] }, { "title": "Identification of Tumor Antigens Among the HLA Peptidomes of Glioblastoma Tumors and Plasma.", "journal": "Molecular & cellular proteomics : MCP", "date": "2019-06", "authors": "Shraibman Bracha, Barnea Eilon, Kadosh Dganit Melamed, Haimovich Yael, Slobodin Gleb, Rosner Itzhak, L\u00f3pez-Larrea Carlos, Hilf Norbert, Kuttruff Sabrina, Song Colette, Britten Cedrik, Castle John, Kreiter Sebastian, Frenzel Katrin, Tatagiba Marcos, Tabatabai Ghazaleh, Dietrich Pierre-Yves, Dutoit Val\u00e9rie, Wick Wolfgang, Platten Michael, Winkler Frank, von Deimling Andreas, Kroep Judith, Sahuquillo Juan, Martinez-Ricarte Francisco, Rodon Jordi, Lassen Ulrik, Ottensmeier Christian, van der Burg Sjoerd H, Thor Straten Per, Poulsen Hans Skovgaard, Ponsati Berta, Okada Hideho, Rammensee Hans-Georg, Sahin Ugur, Singh Harpreet, Admon Arie", "evidence": [ { "database": "IEDB", "id": "879046", "url": "https://www.iedb.org/epitope/879046" }, { "database": "IEDB", "id": "936311", "url": "https://www.iedb.org/epitope/936311" }, { "database": "IEDB", "id": "939219", "url": "https://www.iedb.org/epitope/939219" }, { "database": "IEDB", "id": "943589", "url": "https://www.iedb.org/epitope/943589" } ], "reference": [ { "type": "PubMed", "id": "31154438", "url": "https://glygen.org/publication/PubMed/31154438" } ] }, { "title": "A large peptidome dataset improves HLA class I epitope prediction across most of the human population.", "journal": "Nature biotechnology", "date": "2020-02", "authors": "Sarkizova Siranush, Klaeger Susan, Le Phuong M, Li Letitia W, Oliveira Giacomo, Keshishian Hasmik, Hartigan Christina R, Zhang Wandi, Braun David A, Ligon Keith L, Bachireddy Pavan, Zervantonakis Ioannis K, Rosenbluth Jennifer M, Ouspenskaia Tamara, Law Travis, Justesen Sune, Stevens Jonathan, Lane William J, Eisenhaure Thomas, Lan Zhang Guang, Clauser Karl R, Hacohen Nir, Carr Steven A, Wu Catherine J, Keskin Derin B", "evidence": [ { "database": "IEDB", "id": "1022265", "url": "https://www.iedb.org/epitope/1022265" } ], "reference": [ { "type": "PubMed", "id": "31844290", "url": "https://glygen.org/publication/PubMed/31844290" } ] }, { "title": "Mass Spectrometry Based Immunopeptidomics Leads to Robust Predictions of Phosphorylated HLA Class I Ligands.", "journal": "Molecular & cellular proteomics : MCP", "date": "2020-02", "authors": "Solleder Marthe, Guillaume Philippe, Racle Julien, Michaux Justine, Pak Hui-Song, M\u00fcller Markus, Coukos George, Bassani-Sternberg Michal, Gfeller David", "evidence": [ { "database": "IEDB", "id": "876083", "url": "https://www.iedb.org/epitope/876083" }, { "database": "IEDB", "id": "876587", "url": "https://www.iedb.org/epitope/876587" }, { "database": "IEDB", "id": "879046", "url": "https://www.iedb.org/epitope/879046" } ], "reference": [ { "type": "PubMed", "id": "31848261", "url": "https://glygen.org/publication/PubMed/31848261" } ] }, { "title": "Identification of an Unconventional Subpeptidome Bound to the Beh\u00e7et's Disease-associated HLA-B*51:01 that is Regulated by Endoplasmic Reticulum Aminopeptidase 1 (ERAP1).", "journal": "Molecular & cellular proteomics : MCP", "date": "2020-05", "authors": "Chen Liye, Shi Hui, Koftori Danai, Sekine Takuya, Nicastri Annalisa, Ternette Nicola, Bowness Paul", "evidence": [ { "database": "IEDB", "id": "1079248", "url": "https://www.iedb.org/epitope/1079248" }, { "database": "IEDB", "id": "1079970", "url": "https://www.iedb.org/epitope/1079970" }, { "database": "IEDB", "id": "1079971", "url": "https://www.iedb.org/epitope/1079971" } ], "reference": [ { "type": "PubMed", "id": "32161166", "url": "https://glygen.org/publication/PubMed/32161166" } ] }, { "title": "Immunopeptidomic Analysis Reveals That Deamidated HLA-bound Peptides Arise Predominantly from Deglycosylated Precursors.", "journal": "Molecular & cellular proteomics : MCP", "date": "2020-07", "authors": "Mei Shutao, Ayala Rochelle, Ramarathinam Sri H, Illing Patricia T, Faridi Pouya, Song Jiangning, Purcell Anthony W, Croft Nathan P", "evidence": [ { "database": "IEDB", "id": "1327259", "url": "https://www.iedb.org/epitope/1327259" } ], "reference": [ { "type": "PubMed", "id": "32357974", "url": "https://glygen.org/publication/PubMed/32357974" } ] }, { "title": "Solving an MHC allele-specific bias in the reported immunopeptidome.", "journal": "JCI insight", "date": "2020-10-02", "authors": "Klatt Martin G, Mack Kyeara N, Bai Yang, Aretz Zita E H, Nathan Levy I, Mun Sung Soo, Dao Tao, Scheinberg David A", "evidence": [ { "database": "IEDB", "id": "868437", "url": "https://www.iedb.org/epitope/868437" } ], "reference": [ { "type": "PubMed", "id": "32897882", "url": "https://glygen.org/publication/PubMed/32897882" } ] }, { "title": "Biogenesis of HLA Ligand Presentation in Immune Cells Upon Activation Reveals Changes in Peptide Length Preference.", "journal": "Frontiers in immunology", "date": "2020", "authors": "Marino Fabio, Semilietof Aikaterini, Michaux Justine, Pak Hui-Song, Coukos George, M\u00fcller Markus, Bassani-Sternberg Michal", "evidence": [ { "database": "IEDB", "id": "565810", "url": "https://www.iedb.org/epitope/565810" }, { "database": "IEDB", "id": "1867427", "url": "https://www.iedb.org/epitope/1867427" } ], "reference": [ { "type": "PubMed", "id": "32983136", "url": "https://glygen.org/publication/PubMed/32983136" } ] }, { "title": "CIITA-Transduced Glioblastoma Cells Uncover a Rich Repertoire of Clinically Relevant Tumor-Associated HLA-II Antigens.", "journal": "Molecular & cellular proteomics : MCP", "date": "2021", "authors": "Forlani Greta, Michaux Justine, Pak HuiSong, Huber Florian, Marie Joseph Elodie Lauret, Ramia Elise, Stevenson Brian J, Linnebacher Michael, Accolla Roberto S, Bassani-Sternberg Michal", "evidence": [ { "database": "IEDB", "id": "1612521", "url": "https://www.iedb.org/epitope/1612521" }, { "database": "IEDB", "id": "1621140", "url": "https://www.iedb.org/epitope/1621140" } ], "reference": [ { "type": "PubMed", "id": "33592498", "url": "https://glygen.org/publication/PubMed/33592498" } ] }, { "title": "Carbamazepine Induces Focused T Cell Responses in Resolved Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Cases But Does Not Perturb the Immunopeptidome for T Cell Recognition.", "journal": "Frontiers in immunology", "date": "2021", "authors": "Mifsud Nicole A, Illing Patricia T, Lai Jeffrey W, Fettke Heidi, Hensen Luca, Huang Ziyi, Rossjohn Jamie, Vivian Julian P, Kwan Patrick, Purcell Anthony W", "evidence": [ { "database": "IEDB", "id": "1574568", "url": "https://www.iedb.org/epitope/1574568" } ], "reference": [ { "type": "PubMed", "id": "33912179", "url": "https://glygen.org/publication/PubMed/33912179" } ] }, { "title": "IFN\u03b3 Modulates the Immunopeptidome of Triple Negative Breast Cancer Cells by Enhancing and Diversifying Antigen Processing and Presentation.", "journal": "Frontiers in immunology", "date": "2021", "authors": "Goncalves Gabriel, Mullan Kerry A, Duscharla Divya, Ayala Rochelle, Croft Nathan P, Faridi Pouya, Purcell Anthony W", "evidence": [ { "database": "IEDB", "id": "1898909", "url": "https://www.iedb.org/epitope/1898909" } ], "reference": [ { "type": "PubMed", "id": "33968037", "url": 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tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9NZR2", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9NZR2" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "title": "LDL Receptor-Related Protein 1B Polymorphisms Associated with Increased Risk of Lymph Node Metastasis in Oral Cancer Group with Diabetes Mellitus.", "journal": "International journal of molecular sciences", "date": "2024-04-02", "authors": "Chen Liang-Cheng, Lo Yu-Sheng, Ho Hsin-Yu, Lin Chia-Chieh, Chuang Yi-Ching, Chang Wei-Chen, Hsieh Ming-Ju", "evidence": [ { "database": "RefSeq", "id": "NP_061027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061027" } ], "reference": [ { "type": "PubMed", "id": "38612772", "url": "https://glygen.org/publication/PubMed/38612772" } ] }, { "title": "Antitumor immunity and prognosis value elicited by FAT3 and LRP1B co-mutation in endometrial cancer.", "journal": "Gynecologic oncology", "date": "2024-08", "authors": "Jiang Zhansheng, Zhu Mingyu, Zhang Lu, Cui Haiyan, Jiang Richeng, Yang Yanfang", "evidence": [ { "database": "RefSeq", "id": "NP_061027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061027" } ], "reference": [ { "type": "PubMed", "id": "38696842", "url": "https://glygen.org/publication/PubMed/38696842" } ] } ], "pathway": [ { "id": "hsa:53353", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:53353", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0B4KFD1-1", "protein_name": "LDL receptor protein 1, isoform F", "gene_name": "LRP1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MPATANSWILLLLLLVAVERCSSNSSGRINSRSSSSGYRKVQWQEQQEAPTLRPLPDKGNAHKSRNRIKPTVFIRPNAALTAGGGPCPASYFTCNDGFCIPMRWKCDSKADCPDMSDEGSECAPKCNEGQFRCGVSRHCIPNNWLCDGEFDCGKGDISDELNCPNGDTPKCRAFEGQCRNGDCLELSRFCDGRWDCDNDELQCDKQNAACAALNCSFNCKLTPQGARCYCPKDQVPESSNSTRCVDYDECSEPGTCDQVCRNTPGSYECSCVSGYAKTKGNRCRAINVPPTEPTTLIFLSRDGVQSVGTNGTEVIGPPGAKDNDKVTDKDGVGSEEELLLSQPLRFVHAFEVWHRNRTLCSLLFSWPELQMRCQRVDDARVNWTLPFSSFVSPQQFFTELRLDWLSGNWYLVSEDDGLVYLCTNAMTYCRVILQQVDPLSSLDLDPTKGFMFYTDWTPSLSRSLLDGSNRTVLVTDQVYHPSSVTLDLANELVYWIDIYKDEVNRVDYEGRNRWTLKRPLDSPVPLKTIHAVEVFENSIYLAAWMDTAIVALDKFSLKTHILQSNVSRGANLRIFHRQKQPEVAHPCRDNNAGCNQICVPQWTKGFASAKCMCTAGYKLHNQTTCLLSALDKFLVYSDKHLARISGIPLDTEQVQQLEQIGEQPDVMVPVYNVSKTLAIDVNVRGKAVFYVVADSGASPFGNGEPSCSIRSQSLNGSVSRLLAQGLKRVHAVAFDWINDHLYWTSHKKMQVAPLRNLSKVLTFNTDCDAMSLELDPTTGLLYWSQWESQSCEAGIYSSWMDGTHKELLAKGTSSMPMQWPRSLDVDRRTKELYWCDIRLSTIELMRLDGTGREVLFKSDQFHPYSIVQNNGLIYWADNKNSTILRFHAHQANLSSTFSSTVHLQRTGRAADLRIFDIASQPLPQTPSACAQSKCPGMCLNTPKGAICRCPDGFTLNGTGSHCIPQLAPSPIRPNCTSGYMCRSTRQCLDTKDMCDGFEDCEDGIDESSDPKGPCNVNTCDKTHNFVCNGRCYQRSLLCSTIPYCSDGTDQANCHQNTCNSNEFTCHKSGRCIQLTWVNDGVVDCGPDDDSDETSETIFASKCPEFDCNNGRCRQFADVCDGIDNCGNNADEMECEQECEHGEKYCRPIGCYGEMHMCDGIHDCLDFSDEANCNQTKSDNHPVTEWKELGECAPLEFACMFPFECIPDFLRCDGISHCFDKTDEFNCTHINTTRFDMNETVICEHPDRLCGFSKQCVTVDQLCDGKNDCEDTTDEGFLCADKLCDRGHECSHRCHNTPEGYICSCPDHLYLQPNGKRCSMQHACDHWDTCSQVCESSGKGYDCRCLDGFDLGFDRFTCKSTAPDEPYVIFTNRQDIKGINLKTLNVGNFYSSLRNIIALDFLYNNESNVEIYWTDVIDDKIYRGHLVGESLRNVEAVIHSGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKLNGSFRRTLIAGNMESPRAIALDPREGLLFWTDWDDNSPRIERASMSGDGRRMISTSWQLSAGWPNGLTLDYTQKRVYWVDAKSDSISSTMYDGSEHHVVLRNKEILSHPFAISVFENYVYWTDWRTTSVIRANKWNGSDVQVLQRTQSQPFGIQVLHSSRQPWDRNPCGENNGGCSHLCLLSGRGTFKCECPHVMRLDPANERNCVPNEQVLLFVMVDEIRGIDLHQPNHHTIPTIRQSPRLVAPQRIDFLVDESRIFWSDIQQNEISSAGISNGLIEPIINTNIEKPYGFAVDWIARNMYFSSGQIKCNILASNLKGEFASIIHEDLNMVDSIVLDPANGKMYWIHSASDGSMSQLEQSNLDGSSRSLIYQHENNLQSLTMDFDSQRLYYAYDNSGIAYYDIPRNETRKVLVASPITSISSLTVYNGTLYFPENIQSVIMQCEKEACSNMSYLRVNTKSIQSMKMFYADAQTGSNTCAEWAYRGGCQQLCLATSSIDHVCRCALGYDVEPNNPTGCVPRAEFIFYSIDVLQGVEMIDPSEQFDTPSPALVPISRVSSASFIDYLANTDTLYWGDNELGSISRVKRDGTQRETILEALNLVGYKQQDWLGGIAIDWVAGNIYWSDTKRNIIEVARLDGSHRYVVVSNLEKPTALAVDPLQGLLFYVTQQHIGRVGLDGSQPFVLVNQTRANWAVGSLVLDIEATKVYWCERYPDALMKVDYDGNLREQLLNESLNNPVALAKMGDYLYWAENKYNEGIIRVAPLANLSQSKVVLQTEQDAIRDLKIYSKHLQRGSNPCAHSNGACEQLCLFNGTSAVCACAHSRLASDGYSCEPYENFLLFSYRSNIESIHMTDHADKNWPVQMISNTSLMRNVIAITYNYEEQLVYYSDVQLSTINQVHFNGTGHRVLLEQQQRVEGLAYDIVNEQLFWTSNNNATIRSVELRHLSEHADQNQVHVKKVLSLREDDKPRGIAVEPCLGMIYWTNWNEGSPCIQRSYLTGYGTEVIIKTDIKMPNALTLDLEQQKLYWADARLDKIERTNYDGSNRVVLAHSTPKHAFAMAVYGDLLFWTDWVLHAVVRANKYTGTDVLFLREHVTRPMGIVAVQNTSINCDANQCKILNGQCEDVCILNKSGQATCHCTQGVLAPDGRRCIAPVNTSCGLSQYNCHSGECIPLELTCDNVTHCADGSDEFRSYCIFRQCPETHFMCQNHRCIPKEHKCDGEQQCGDGSDETPLLCKCQSEDIDMHPSNNNTKEMPDMFRCGSGECIPRKFLCDSLKDCRDFSDEKMCAPIPCEKNDMTFVHCGNSTICIMPRWRCDGDPDCPDGTDELDCANHTSLSCDPGQFRCASGNCIAGSWHCDGEKDCPDGSDEINCRTECRHNQFACDKTCIPASWQCDGKSDCEDGSDEGPQCPNRPCRPHLFQCKSSGRCIPQKWVCDGEKDCPSGLGDEGSEDEGPQCGGVAHIPDCPPPAHLCTSGLCIDSHYVCDGDEDCPGGDDEYEGCVPAFQPHSCPGGSLMHQCQDGLCIFKNQTCDGKPDCGDGSDETSSLCAHTRGCNGTDDFRCKNGACIHADLLCDRRNDCADFSDEELCNVNECLIPDICEHECEDKVVGYQCHCRPGYKVLPKSPHLCTDIDECDEQQPCSQTCINTYGSYKCLCAKGYALVDHHTCKATSNVSMELIFSNRYYIRQVDMTGNGSILINELSNAVALDYDWDSQCLYWSDVTSTVGTIKRYCPKENKTQTLHQAMLKNPDGLAVDWVAKNLYWCDKGLDTIEVSQLDGKYRKVLINEYLREPRGIALHPYQQHIFWSDWGDSPHIGKAGMDGSNPKMIIRDGLGWPNALTISFETQQLFWGDAREDTISVSDLDGNHTRLLLARSINPLLNLHHIFAIAVWEGHIYWSDWETKSIEYCSIFNGQNCTTLITTIHRPMDLRVFHPYRQQQPMSGNPCLAANCSTLCVLSPEEPYYKCMCPTNFILADDGRTCRANCTAAHFECVNTYKCIPFYWRCDTQDDCGDGSDEPETCPPFHCEPGQYQCANKKCTHPSNLCDGINQCGDGSDELNCDKFTCFDNHMKCGATANSSAFCVDNVKRCDGVKDCPGGEDESACTPLVCKKDQFQCGNNRCMPFVWVCDGDIDCPDKSDEANCDNVSCGPNDFQCDSGRCIPLAWRCDDDHDCPNGEDEPASCFSSKATCDPTYFKCNNSKCIPGRWRCDYENDCGDGSDELNCQMRNCSESEFRCGTGKCIKHNYRCDGEIHCDDNSDEINCNITCKENQFKCAAFNTCINKQYKCDGDDDCPDGSDEVNCTCHSDHFSCGNGKCIMSRWKCDGWDDCLDGSDESLETCAKTHCHANAFKCRNQLCVRNSALCDGINDCGENEDESDAVCAALPKCRHDQFQCENDDCISKAFRCDGQYNCVDGSDEMNCQPPVCGFGSCSQICIEKKAGHYNCKCADGYHKGPEKNATCLASGPDQILLLASEQEFRFILPAKQEGTTVVGFFQTDSLKIDVFDILIRPKDTLLFWIDSHHGKVHTMKIATPHVEGTGVRVRRDLKELTAFNIPELDDPKSLAVDWISQRVYIIDSRHNQILATDIEGKKYISLVSTGMNPTDIVLEPESRIMIWSTLENGILVASLDGSNKKSLVERDVGWPISLSMDYPTGRLYWADYRKGTIETCRLNGKDRNVVRRFGNREKPQKIDVFEDYLYIKLYDQSIIKMNKFGNDNGTYLLKGYRSSDIGILHPMKQNRNISNPCAKDPCKSSRALCILSSESSVGYSCKCAEGYVMTDDGVCKAHADIPDYCPLQCNLGTCKIVDHVPKCICQPQFEGELCEHYRCSGYCQNYGVCSVAPALPGSQEPPPLKCTCTAGWSGARCETSMPACQSRCHNGGSCLISETEGMKCSCPKMFTGEQCEHCRNLTCENGGICRETLTGTPQCECPDGFTGKRCEIDECADFCKNGGSCVISTKGQRQCKCPSGYFGEHCESNSCRDFCRNGGTCSERGGRLSCTCPPRYIGESCESDLCKTSSPPHFCDNTKVPTRDPCTLMICQNAGTCHIIKGVALCNCTDQWNGDLCTLPVTDDNPCARYCANGGVCHLDEYRLPHCSCIGEWQGNACEMPPHCVGGECNVCRPGSSINECLCENNRVVPCLSDSADALKEEQEPTESGGVFSVVVLVLAVILLVFALFAGAVYFLKKHRIAQPFSHARLTDNVEIMLTNAMYRGDADEAPTFASEDDKGNFANPVYESMYADAIPEPVSTEITHSTAPDERKGLLQHTHDENHTPDIL", "length": 4752 }, "evidence": [ { "id": "HGNC:6693", "url": "https://alliancegenome.org/gene/HGNC:6693#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-070912-401", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070912-401#orthology", "database": "AGR" }, { "id": "MGI:2151136", "url": "https://alliancegenome.org/gene/MGI:2151136#orthology", "database": "AGR" }, { "id": "RGD:1306160", "url": "https://alliancegenome.org/gene/RGD:1306160#orthology", "database": "AGR" }, { "id": "FB:FBgn0053087", "url": "https://alliancegenome.org/gene/FB:FBgn0053087#orthology", "database": "AGR" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "A0A8M9PTJ2-1", "protein_name": "Low-density lipoprotein receptor-related protein 1 isoform X1", "gene_name": "lrp1ab", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPSCNANMLAVGLLYLGLVLALEVVDPTRAIEAPKTCSPKQFVCKDQVTCISKGWRCDGEKDCPDGSDESPDICHHTQVTQCPPNEFECRGTDVCIHLSKLCDGVPDCTDGRDEGPHCRELASKCSIMDCQYNCSVTLSGPKCYCKNGYEVGEDGKTCKDFNECAVYGTCSQTCTNSEGSYTCSCVEGYLPQLDNRSCKAKNDPVDRLPFLLIANSQNIQATSLSGANPITINDKQTTTMDFIYAQETVCWIHMGDSPTASQLKCAKFPNAKSFTEEKTINISLSLHHMEQMAIDWLTGNFYFVDNVDDRIFVCSKDGSICVILLDMELYSPKGIALDPAMGKVFFTDYGQTPKVERCDMDGQNRTKLVDSKIVFPNGITLDLANKLVYWTDAYLDYIEVVDYEGKNRHTIIQGLLIEHLYGLTVFENYLYATNSDNANMQPKTSVIRVNRFNSSDFQVVTRVDKGGALHVYHQRRQPTVRSHACALDPFGKPGGCSDICLLANSHKTRTCRCRSGFSLGSDGKSCKKPEHELFLIYGKGRPGVIRGMDMHSTVYDEHIVPIENLNNPRALDFHAETEFIYFADATSYIIGRQKLDGTERDIIVKDGIHTVEGIAVDWMGQNLYWTDDGPKKTISVAKLEKASQTRKTLIEGKMTHPRAIVVDPSHGMMYWSDWEEEPKEMNRGSIRKAWMDGSNAGILLTSKTVLWPNGLSLDIQQGLLYWVDAYYDRIEMVLLNTTERRTVYEGQELNHPFGLCHHKNFLFWNEYRGGGIYKLDQNTKKATLLRNERPPIYEIRTYDAQQQQIIGSNVCRANNGGCSSLCLLTPTGRSCACADDQILDTDNKTCRANPSYVPPPQCQPGEFACKNNRCIQERWKCDGDNDCLDNSDETPDLCNQHTCPADRFKCQNNRCIPLRWLCDGDNDCGNDEDESNSTCLARTCPSNQYPCASGRCIPVSWMCDLDDDCGDRSDEPASCAYPTCYPLTQFTCANGRCINVNWRCDNDNDCGDNSDEAGCSHSCSSVQFKCNSGRCIPEYWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRMDGLCIPMRWRCDGDTDCMDLSDEKNCEGVTHMCDPAVKFACKDSARCISKAWVCDRDSDCEDNSDEENCEALECKLSHHVCASNDSICLPPEKLCDGKDDCPDASDEKLCNLCTVENGGCSHNCTIAPGEGVLCSCPAGMELGTDNKTCQIQSFCAKHLKCSQRCVQEKATVKCACYEGWALGPDGESCKSTDPFKPFIIFSNRHEIRRIDLYKGEFSVLVPGLRNTIALDFHFNQSSLYWTDVVEDKIYRGKLSENGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTMRTTLLAGEVEHPRAIALDPRDGILFWTDWDASSPRIEAASMSGEGRRTIHKETGIGGWPNGLTVDYLERRILWIDARSDAIYSAAYDGSGLIEVLRGHEHLSHPFAVTLYGGEVYWTDWRTNTLARANKWTGHNVTVVQRTNTQPFDLQVFHPSRQPQAPNPCAANDGKGPCSHLCLINYNQTFSCACPHLMKLKADKHTCYEYRQFLLYARQIEIRGVDIDNPYYNYIISFTVPDIDNVTVVDYDALEHRIYWSDVRTQTIKRAFINGTGVETVVSADLPNAQGLAVDWISRNLFWTSYDTNKKQINVARLDGSFKNAVIHGQGLDKPHCLVLHPILGKLYWLDGDNISMANMDGTNHTLLFTNQKGPVGLSIDFDSEQLYWISSRNSTINHCKMDGSGLEVIESVKGKLTKATALAIMGDKLWWADQSTDQIGTCDKSDGGNWKVLRYHTSPMMHMKIYNESVHQIGTNLCSKNNGDCSQLCLPTSPSTRACMCTAGYSLKSGQQSCEGMGSFLLYSVHEGIRGIPLDPSDKSDALVPVSGTSLAVGIDFHADNDTIYWVDMGLSTISRAKRDQTWREDIVTNGIGRVEGITVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISHGLDKPRAIAVHPEKGYLFWTEWGQYPRIERSRLDGSERVVLVNVSISWPNGISIDYQEGLLYWCDARTDKIERINLETGENRELVLSSNNMDMFAVSVFEDYIYWSDRTHANGSIKRGNKDNATDMVYLRTGIGVQLKDIKVFNRARQQGTNVCKVNNGGCEQLCLFRGNGNRTCACAHGMLAEDGHSCRDYDGYLLYSERTILKSIHLSDETNLNAPIKPFEDPEHMKNVIALTFDYRGGGGKGANRIFYSDIHFGNIQHINDDGSDRKTIVDNVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQSRSGAFDRDTVVTMSGDDHPRAFVLDECQDLMFWTNWNEQSPSIMRASLSGANVLVIIGNNIRTPNGLAIDHRAEKLYFSDATFDKIERCEYDGSRRFVVLKNEPVHPFGLAVYGDYIFWTDWVRRAVLRADKYGRDMKVLRADIPQQPMGIIAVAKDTNSCEFSPCLTNNGGCQDLCLITSEGRVNCSCRGERKLLGDNTCVAENTTCNSVDEFECGNGDCIDYSLTCDSLAHCKDKSDEKQAYCANRMCKKGYRRCINGRCIKHSSWCDSTDDCGDGSDELPCNMTLCSAAEFQCKDGSCITNSSRCNQVVDCEDASDEMNCSPTDCSSYYLLGVKGMTFERCEFTTLCFAPSWRCDGSNDCGDFSDERNCPEKRQQKCSENNFACPSGRCIPMSWTCDKENDCEDGADEAHCEKFFQFCASNQFECGNHRCIFKTWVCDGTDDCGDGTDEDSRCKAKTCGPDSFQCPGSHVCILQRWVCDGDKDCPDGGDEGLKAGCVFNKTCDDTEFQCQNSQCIPKNFMCDHDIDCRDGSDESPECEYPTCGPNDFHCANGQCLKQKNWACDGEFDCRDQSDEAPKNLQCTDTESRCNDTAFLCSSGKCVNETLLCDNNNDCGDGSDENNCFVNECLNSKLSGCSQLCEDLKIGFKCRCNAGFRLKQDGKTCVDLDECSTVYPCSQRCINTHGSFHCLCVDGFVPRPDDHTSCKSTAEEEPFLIFANRYYLRKLNLDGSNYTLIKQGLNNAVALDYHYAEQMIYWTDVTTQGSMIRRMHINGSNVQVLHRTSLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRSVLVNSGLREPRAVAVDVRNGYLYWSDWGDVPHIGRIGMDGTDRQIIIQDKITWPNGLTLDFINDRIYWADAREDYIAFASLDGSNRHTVLNHDIPHIFAMTLFEEFIYWTDWETKSINRAHKTLGTNKTLLISTLHRPMDIHIFHPSRQPEVSGHPCQEDNGGCSNLCLLSPGGGYKCACPTNFYLAADGKQCLSNCTASQFVCKNDKCIPFWWKCDTEDDCGDRSDEPADCPEFKCRPGQFQCGTGLCTNPAYICDGDNDCQDNSDEANCDIHVCLPSQFKCSHPSRCIPGILRCNGQNNCGQGEDEKDCPEVTCAPNQFQCAITKRCIPRVWVCDRDYDCVDESDEPANCTQMKCGVDEFRCKDSGRCIPSRWTCDGEDDCGDASDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEEKCVPRQCSESEFACSNGRCIAGRWKCDGDHDCSDGSDEDGCDLKCEEDQFQCKNGHCIPLPWRCDADVDCLDGSDEERCEITEVRHCSSEEFQCNNTLCKPLSWKCDGEDDCGDNSDENPEACRHFQCPPTRNFRCRNNRVCLTRSKLCDGVDNCGDNSDEASCDYESTCDKDQFRCTNGKCISANLRCNFFNDCEDYGSDEIGCKTDTMLNDCKSNKSLCGDGDEAHCVSNGTDTFCSCKPGFQSVRHNTCEDKDECKQFGVCSHVCNNTKGSYKCSCHKYFTRINHTCKADGQNSNKQVLYIADDNEIRSLNPGMPNWVYEQTFQGDNNVRIDAMDLHVKTNRIFWTNWHTYGISCFQLPSQSSASGPTSNSHRHTRQSEGTVSNLEIPGLKMPRGIAVDWVAGNLYWTDSGRDVIEVAQITGQHRKTLISGMIDEPHAIVVDPQRGTMYWTDWGNHPKIETAAMDGTLRQTLVHENIQWPTGLAVDYFNERLYWADSKLSVISSVRLDGSDPVVAVSNLKNNLLRPYSIDIFEDYIYGVTHTNNIVFRVNKFGKGQAENLTTGINHATDIVLYHRYKQPEMTNPCDRKKCEWLCLLSPSGPVCICPNDHVPDNGTCVKVQPPDQFPFSPTCDLQCQNGGSCYLNPLKNPKCRCPTSYRGERCEINQCRDYCQNRGTCSPSRTGAPTCRCQTGFTGPRCNLYICENYCQNGGNCAVSLGNQPTCRCPPGFLGDQCQYRQCEDFCKNDGQCLELNNGTKHCQCSDKFFGPQCELDKCEYCGTGKCEKLQTGITCKCADNTKRPTCYTCDDFCIEGQCSVDTYTNLPQCRCHTGWSGFRCELNVAPVQNSDSGNTPSVVIPVMLLLLLALLVVAAILWYKKRMRGSVMRGKPSSRCSRAKGFQHQRMTNGAMNVEIGNPAYKIYEGEPDDDAGELLDSDFTLDPDKPTNFTNPVYATLYMGAHNSRNSLASTDEKKELLSAGDDDMGDPLA", "length": 4562 }, "evidence": [ { "id": "FB:FBgn0053087", "url": "https://alliancegenome.org/gene/FB:FBgn0053087#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0AC58GH22-1", "protein_name": "Low-density lipoprotein receptor-related protein 1B isoform X1", "gene_name": "lrp1bb", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRLERFNNAVTNWQRWTKSVRRVKKKACCQRDVLQETDSSSPRKIISSLCRYIENSEPILCDVGEFLCGDQLTCVSDNWLCDGEPDCPDGSDEALDKCQVEVIVRCPLNHIQCVGSRKCIHFNKLCNGAKDCEDGFDEGVHCRELLSACHELHCRYGCIMTRNGTFCFCADGFEVGEDGRSCRDHDECAMYGTCSQTCMNTYGSFRCSCTDGFSLQPNRRSCIAKHEPGESPAALLIGGSDNIIITALNGSRLQTLKQLDSNGTHGLDFNHKEESVCWVTSSESSGQLRCARMKKASGFTKEQEVKTVQNLHDVDQLTFDWLTGNFYFVDQASDRIFVCNQLGDTCVTVVDLDLLNPKAIALDPLMGMLFFTDYGNVAKLERCNMDGTNRTRLVDYKVERPTAVALDLVKKLVYWADAYLDYIEMVDYNGKNRHTIMQGYQVAHLHGLAVFEDYLYATRSEASSGTVVDILRINRFNVTDPEMLTSIGNAKTIRVYHKLCQPKVKGHACEVDSYGKPGGCSHICLLSGSYKSRSCRCRTGFRLGNDGQSCKKPKNDLFLFYGKGRPGIIRGLDMNVKSSDEHMVPIEDLVNPRALDYHAETGNIYFADTTSFLIGRQKVDGSNRETILKDDLDNVEGISVDWIGNNLYWTNDGYRKTISVARLERASETRKTLLEGDMSHPRAIVVDPLNSWMYWTDWEEDEVNDSIGRIEKAWMDGSNRKIFVTSNMLWPNGLTLDHGTSTMYWCDAYYDHIEKIYLNGTGRMVVYSGRELNHPFGIAQYQNSIFWTEYMNASIFQLDLLSAEVSLLRSERPPLFGLRVYDAQSQLGDNPCRVNYGGCGTLCLAVPGGRVCACADNQHLDKHNLTCSDSAGQEEPQRCRSDEFQCRNGRCIRVNWICDGDDDCLDGSDEEPHICSNHSCPIDQFKCPSNRCIPKRWLCDGADDCGDNEDESNKTCSAQPCRAGQFTCGNGRCVPEAWRCDQDDDCGDMSDESTSCSFPTCEALSQFSCANGRCISMKWHCDSDDDCGDNSDEAGCVHFCANGQYKCTSGRCIPDHWACDGDNDCGDFSDENVTCAGVAPALPPVECSAEEFHCRADGTCIPERWRCDGDKDCEDGSDETNCKGVKRMCDPQAKFTCKTSGKCISKSWVCDGDDDCEDRSDEESCVSSICKPPTQPCANDSSICLPQNKICDGRMDCADRSDEGPFCERCLQGNGGCSHQCSVIPSKGVVCSCPAGLHLGSDNRTCEAVDYCSAHLKCSQICEQHKTTVKCSCYPGWRLDADGESCHSTDPFEAFVIFSIRHEIRRIDLHKHDYSLLVPGLRNTIALDFHFSHSLLYWTDVVEDKIYRGKLSETGGVTGVEVVIQHGLATPEGLAVDWIAGNLYWIDSNLDQIEVAKLNGEMRTTLIAGGMEHPRALAVDPGQGILFWTDWDATFPRIEATSMSGSGRHVVYKDMEIGAWPNGLTLDHQERRIVWTDARSDAIYSALYDGSGVIEILRGHEYLSHPFAVSLFGGGVYWTDWRTNTLARANKWTGHNVTVIQKTSAQPFDLEIYHPSRQPQASNPCEGNDGRGPCSHLCLIDYNRTASCSCPHLMKLSLNNRSCVALKKFLLYVRRSEIRGVDIDNPYMNVMTALTVPDIDDVTVVDYDALEERIYWADVKTQTIKRAFINGTGLQTVISGDIQNCRGLAIDWLSRNMYWLSSENEETQINVARLDGSLKTSVIHGIDKPKCLTVHPAKGKIYWTDGNTINVANMDGSNRKVLHQNQKEPVGLSIDFPAGKMYWISSANGTINRCNLDGSGFEVIESMKRDLTKATALAVMGGKLWWADDDLAQLGTVAKRDGRNPVVLRNKTSGLVHMKVYDRDGQKGRNACQLNNGGCSQLCLPTSENTRTCACTIGYNLRNDRLSCEGLNSFLMYSFHEGIRGIALDPNDHTETLMPISGTLFAVGVDFHAGNDTVYWTDMGLNRISRAKRDQTWREDIITTGINRVEGIAVDWIAGNLYWTDHGLNLIEIARLNGLYRSVVISEGLDQPRAIAVHPQRGYLFWTEWGKNPCIGRARLDGSDQVTLVSSGIAWPNGITIDYEENRLYWCDARTDKIERINLETGEGREIVLSAANVDLFSVAVFGAYIYWSDRAHANGSIRRGFKSDATDAVTMRSGLGVNLKDVKVFNKGREKGTNPCARSNGGCQQLCFHLGSGRRTCSCAHGYLAEDGFACQRYGGYLLYSERTILKSIHLSDESDLNSPLQPFENPDYFKNVIALAFDYRQESSPHNRIFFSDIHFGNIQMINDDWSGRQVIVENVGSVEGLAYHRAWDTIYWTSSTTSSISRYTVDQSRQGAFGRQAVVTMSEDDHPHVLALDECQNLMFWTNWNEQRPSIMRSTLAGNNMKVIISTDVFTPNGLTIDHKAEKLYFSDGSLGKIERCEYDGSHRHVIVRSGPGTFFGLAIHGNYIFWSDWTRRAVLRTNKFTGGETKVLRADIPHQPMGIIAVAKDTNNCELSPCRVQNGGCGDLCLLTPDGTVNCSCRGERVLLDDNRCVSKTSSCNIHTEFECGNGECIDYQLTCDGIAHCKDKSDEKMQYCDNRSCRKGHRPCYNRRCVANSRFCDGIDDCGDNSDEAFCNNVTCAASESSCQDGTCIPISSWCNQVIDCADASDEKNCNHTDCTDFYRIGVAEKVFVSCNTTSLCVHHSWLCDGANDCGDYADERNCQVSQGQKCAEGHFACPSGNCISSVWLCDGQKDCEDGADEFQCDSSCLWNQFACSKNKCIAKQWLCDGEDDCGDGVDESVDLCGSVTCAPGLFSCPGSYACVPKRWLCDGERDCPDGSDELAAAGCAPNNTCDENSFRCLNKGCIPKRFVCDHDNDCGDGSDESLECVYRSCGPDEFRCADGRCLLSAQWECDGYPDCPDHSDELPLNLKCLAAESLCNSSFFMCSNGRCISEKSLCDMKDDCGDRSDEKNCNVNECLNRRVSGCTQDCQDLPVGYKCKCWPGFHLKNDGRTCVDIDECSTTLPCSQNCTNTYGSYKCLCVDGYEASRKDPNSCKSLSAEEPFLILADLHEIRKLSVDGSNYTLLKQGLNNIISLDFDYKKEFIYWIDSSRPSGRRINRIRLNGSDLKIVHRTAVPSALAVDWIGKNLYWCDVERKTLEVSKSNGLYPTILVSSGLKNPTDLALDAQTGYVFWIDCCENPHVGRIGMDGQGQSVIVNKEIYSPSALTIDYTNKRIYWADDNHILFANMDGSQRHRVPHDHIQGVMGLTLFEDFIYWTDGKSKSLRRAHKTTGANAVELLNSWQAIKSVIVYHPLRQPEVPKHQCQVANGGCSHLCLLSPGGGHKCACPTNFYLAADNKTCLSNCTASQFRCGTDECIPFWWKCDTVDDCGDGSDEPADCPEFKCQPGRFQCGTGLCALPPFICDGENDCGDNSDEANCDTYICLSGQFKCSRKQKCIPLNLRCNGQDDCGDGEDETDCPESTCSPDQFQCKASMHCISKLWVCDEDPDCADGSDEANCDEKTCGPHEFRCENNNCIPDHWRCDSQNDCGDNSDEEHCKPVTCNHKDFACANGDCISARFRCDGDYDCADNSDEKDCETHCAEDQFQCHNNLCISRKWLCDGQEDCKTGEDERNCLGTVLPSCSLNEYVCASGGCVSASLRCDGHDNCLDSSDEMDCVKECREDEFLCKNHAHCVPKRWRCDDIFDCVDHSDEENCSHDAFFCRPDEFICNNTLCKLHVWVCDGEDDCGDNSDEDPDMCAKLPCPPARPYRCRNDRVCLRLDQICNNVDNCGDNSDEDECEAVSTRPKPCGKAEFTCSNRKCIPAQLQCDLFDDCGDGGSDEQDCKASSNGDICGKRMNPCGEDAVCNHTNTNAICHCKPGFQRNLRSRKCEEINECLYFGTCSHYCTNTKGSYKCTCDKNYKDMNGSCIAKGPEDRVLYIANDTEIRSFVYPFNQSHGHKVHARIEENARIIGMDALFHQQKFIWATQFNPGGLFYKDILNRSQTKTNVGIICPDFRRPRDVSADWVTGNIYWTDHSRMHWFSYYTAHWTKLRYSINVGQLKGPNCTRLITDIAGEPYAIAVNPVKGMMYWSVIGDHSHIEESAMDGSMRRVLLDKKLRRPTGLAIDYFSQRVYWADAELSVIGSVRFDGSDTLVVIDGKQGISQPYRIDIFEDHIYGTGLKNEVFRIHKYGKRPIEPLDLGIEKTTNVLISHRFKQQDVANPCLRMTCEFMCLLNPTGASCTCPEGKTLVNGSCIDPIVSGELCRPACENGGRCMANEKGDWRCYCWPNFSGERCEVNHCADYCLNGGTCTGSPLGKPTCRCVTGFTGPNCERRICDNHCLNGGTCDVSSGNQPVCRCLAEYTGDRCLYHICHHHCVNSKACTLSSSGHVECVCPARYEGIKCDVDKCLRCHGAPCIINGDTGDVACNCTSGRIASSCQLCDGYCYNGGTCHLDPDTSLPFCHCTAGFKNQRCDELANPCDYYCQNEGICTITALNKPRCKCSANWSGTQCERPAPKSSRSDNTAGGSIAIIVPLVLLVILITTVVTGVFICRRRQRGKRVQRQPITNGGINVEIGNPSYNMYEVDHDNHADAGSLLKPNFTLDPHKGWCVKSSDPCTLNIHTVPKEVIPGQPMNYSNPMYAKMYLDGQNCRKPVINIDERRELLPKKLEGTIRETAA", "length": 4666 }, "evidence": [ { "id": "HGNC:6693", "url": "https://alliancegenome.org/gene/HGNC:6693#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-070912-401", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070912-401#orthology", "database": "AGR" }, { "id": "MGI:2151136", "url": "https://alliancegenome.org/gene/MGI:2151136#orthology", "database": "AGR" }, { "id": "RGD:1306160", "url": "https://alliancegenome.org/gene/RGD:1306160#orthology", "database": "AGR" }, { "id": "FB:FBgn0053087", "url": "https://alliancegenome.org/gene/FB:FBgn0053087#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1M443-1", "protein_name": "Low-density lipoprotein receptor-related protein 1B", "gene_name": "Lrp1b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSNRYKNGFVLRDIRKLFFTDFGNAPRIERCDMDGMNRTRIVYSKTEQPSALALDLINRLVYWVDLYLDYVGVVDYQGRNRHTLVQGRHVKHLYGITVFEDYLYATSSDNLNIVRINRFNSTDIHSIIKMESARGIRTYQKRTQPTVRSHACEVDAYGMPGGCSHICLLGSSYKTRTCRCRTGFNMGSDGRSCKRPKNELFLFYGKGRPGIVRGMDLNTKIADECMIPIENLVNPRALDFHAEANYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRAIVVDPVNGWMYWTDWKEDKIDDSVGRIEKAWMDGVNRQIFVTSKMLWPNGLTLDFHTSTLYWCDAYYDHIEKIFLNGTHRKIVYSGKELNHPFGLSHHGNYVFWTDYMNGSIFQLDLVSREVTLLRHERAPLFGLQIYDPRKQQGDNMCRINNGGCGTLCLAIPGGRVCACADNQLLDENGTTCTFNPEEIIFHICKPGEFRCKNKHCIQARWKCDGDDDCLDGSDEDSVTCFNHSCPEDQFKCQNNRCIPKRWLCDGANDCGSNEDESNQTCTARTCQADQFSCGNGRCIPTAWVCDREDDCGDQTDEVTSCEFPTCEPLTQFLCKSGRCISNKWHCDTDDDCGDRSDEVGCVHSCLDDQFRCASGRCIPGHWACDGDNDCGDFSDETHVNCTREEARSPVGCIGNEFQCHPDGNCIPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCKSTGRCINNAWVCDGDVDCEDQSDEEDCDSFLCGPPKYPCANDTSVCLQPEKLCNGRKDCPDGSDEGDLCDECSLNNGGCSNHCSVVPGKGIVCSCPEGHQLKKDNRTCEIVDYCSSHLKCSQVCEQHKHMVKCSCYEGWALDTDGESCISVDSFEAFIIFSIRHEIRRIDLHKGDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVSKLDGSLRATLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFERRIVWTDARSDAIYSAFYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLAKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANEGRGPCSHLCLINHNRSAACACPHLMKLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYANFITAFTVPDIDDVAVIDFDASEERLYWTDIKTQTITRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSIIHGIDKPQCLAAHPVRGKLYWTDGNTINMANMDGSNSKILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCNKRDGRNPSILRNKTSGVVHMKVYDKEAQQGSNSCQVNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGVESFLMYSVHEGIRGISLEPRDKVDALMPISGAAFAVGIDFHAENDTIYWTDMGLNKISRAKRDQTWKEDIVTNGLGRVEGIAIDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGFLFWTEWGQVPCIGKARLDGSEKVMIVSMGITWPNGISIDYEENKLYWCDARSDKIERIDLDTGGNREVLLSGSNVDLFSVAVFGAYIYWSDRAHANGSVRRGHKNDVTETVTMRTGLGVNLKEIKIFNRVREKGTNVCAKENGGCKQLCLYRGNSRRTCACAHGYLAGDGVTCLRHEGYLLYSGRTILKSIHLSDETNLNSPVRPYENPHYFKNIIALAFDYNQRREGTNRIFYSDAHFGNIQLINDNWEGRQVIVENVGSVEGLAYHRAWDTLYWTSSSTSSITRHTVDQTQPGAIDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQHPSIMRATLTGKNAHVVVSTDILTPNGLTIDHRAEKLYFSDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGETKVLRSDIPHQPMGIIAVANDTNSCELSPCALLNGGCHDLCLLTPDGRVNCSCRGDRTLLASNRCVTKNSSCNIYSEFECGNGDCVDYVLTCDGIPHCKDKSDEKLLYCENRSCRSGFKPCYNRRCVPHGKLCDGTNDCGDGSDELDCKVSTCSTVEFRCTDGTCIPRSARCNQNMDCSDASDEKGCNNTDCTHFYKLGVKSTGFIRCNSTSLCVLPSWICDGSNDCGDYSDELKCPVQNKHKCEENYFGCPSGRCILNTWVCDGQKDCEDGLDELHCDSSCSWNQFACSVHKCISKHWICDGEDDCGDGLDESDNICGAVTCAADMFSCQSSHACVPQHWLCDGERDCPDGSDELSSAGCAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDEFLECGYRQCGPEEFRCADGRCLVNTLWQCDGDFDCPDSSDEAPINPRCTSAEHSCNSSFFMCKNGRCIPRDGLCDNRDDCGDGSDEAKCHINECLSKKISGCSQDCQDLPISYKCKCWPGFQLKDDGKTCVDIDECSTGFPCSQQCINTYGTYKCRCTEGYETQPDNQNGCRSLSDEEPFLILADQHEIRKISTDGSNYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTVLVSKRLKFPRDLSLDPRAGNLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNHRLYWADENHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRVHKTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLCTVNNGGCSHLCLLGPGKTHTCACPTNFYLAADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFKCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLAGQFKCTKNKKCIPVNLRCNGQDDCGDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLRDFLCSNGDCVSSRFWCDGEFDCADGSDEKNCETSCSKDQFQCSNGQCLSAKWKCDGHEDCKYGEDEKNCEPAFPVCSSSEYMCASGGCLSASLKCNGETDCVDGSDEMDCVTECKEDQFQCRNKAYCIPIRWLCDGIYDCVDGSDEENCGRGGSICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEVPDMCVKFLCPPTRPYRCRNDRICLQLEKMCNGINDCGDNSDEEHCSGTLSFKSEPCKKDEFTCNNRNCIPMELQCDGLDDCGDGSDEQGCMQTPTQHTCENNGNPCGDDAYCNQIRTSVFCRCKPGFQRNIKGRECADLNECLVFGICSQHCLNTRGSYKCVCDQNFQEKNNSCIAKGSEDQALYIANDTDILGFVYPFNYSGSHQQISHVEHNSRITGMDVYYQRNVIVWSTQFNPGGIFYTMIDAREKRQANSGLICPEFKRPRDIAVDWVTGNVYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVIGDHSHIEEAAMDGTLRRILVQKHLQRPTGLTVDHFGERIYWADFELSIIGSVMYDGSSPVVSVSSKQGLLHPHRIDVFEDYIYGAGPKNGIFRVQKFGHGSVEVLTLDVDKTKSIVVSHRYKQLNLPNPCLGLSCDFLCLLNPSGATCVCPEGKHIRNGTCHENSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSYSGGRCEVNHCSNYCQNGGTCIPSALGRPTCICALGFTGPNCGKTVCEDSCHNGGSCVVTAGNQPYCHCQADYTGDRCQYYVCHHYCVNSESCSIGNDGSVECVCPTRYEGPKCEIDKCVRCHGGHCIINQDNEDIFCNCTNGKIASSCQLCDGYCYNGGTCQLDPETSVPVCVCSTNWSGTQCERPAPKSSKSEHISTRSIAIIVPLVLLVTLVTTLVIGLVVCKRKRRTKTIRRQPIINGGINVEIGNPSYNMYEVDHDHSDGGLLEPSFMIDPVKPTNYSNPVYAKLYMDGQNCRNSLGSVDERKELLPKKIEIGIRETVA", "length": 4243 }, "evidence": [ { "id": "HGNC:6693", "url": "https://alliancegenome.org/gene/HGNC:6693#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-070912-401", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070912-401#orthology", "database": "AGR" }, { "id": "MGI:2151136", "url": "https://alliancegenome.org/gene/MGI:2151136#orthology", "database": "AGR" }, { "id": "RGD:1306160", "url": "https://alliancegenome.org/gene/RGD:1306160#orthology", "database": "AGR" }, { "id": "FB:FBgn0053087", "url": "https://alliancegenome.org/gene/FB:FBgn0053087#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3V928-1", "protein_name": "Prolow-density lipoprotein receptor-related protein 1", "gene_name": "Lrp1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLTPPLLLLLPLLSALVAGATMDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCPPNEHSCLGTELCVPMSRLCNGIQDCMDGSDEGAHCRELRVNCSRMGCQHHCVPTPSGPTCYCNNSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFTCGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPSLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANTQQKTSVIRVNRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVAGAQPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANNRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHSDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKGCEGVTHVCDPNVKFGCKDSARCISKAWVCDGDSDCEDNSDEENCEALACRPPSHPCANNTSVCLSPDKLCDGKDDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTIHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGRGPCSHLCLINYNRTVSCACPHLMKLHNDNTTCYEFKKFLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVVQGLEQPHGLVVHPLRGKLYWTDGDNISMVNMDGSNRTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSELEVIDTMRSQLGKATALAIMGDKLWWADQVSEKMGTCNKADGSGSVVLRNSTTLVMHMKVYDESIQLEHEGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGHYPRIERSRLDGTERVVLVNVSISWPNGISVDYQGGKLYWCDARMDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHANGSIKRGCKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGGGQRACACAHGMLAEDGASCREYAGYLLYSERTILKSIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSGRTTIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNELHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKYVGSDMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQEDFTCRAMNSSCRAQDEFECANGECISFSLTCDGVSHCKDKSDEKPSYCNSRRCKKTFRQCNNGRCVSNMLWCNGVDDCGDGSDEIPCNKTACGVGEFRCRDGSCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDKEDDCENGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESISAGCLYNSTCDDREFMCQNRLCIPKHFVCDHDRDCADGSDESPECEYPTCGPNEFRCANGRCLSSRQWECDGENDCHDHSDEAPKNPHCTSPEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDGSDERGCHVNECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQLCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDYRGQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSGRSIIVDTKITWPNGLTVDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGANKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGGDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECTRFQCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAQNPHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASMCGDEARCVRTEKAAYCACRPGFHTVPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARNFMKTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAVDSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLINLTGGLSHASDVVLYHQHKQPEVTNPCDRKKCEWLCLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTCTLQCFNGGSCFLNARRQPKCRCQPRYTGDKCELDQCWEYCHNGGTCAASPSGMPTCRCPTGFTGPRCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGFCENFGTCQMAADGSRQCRCTVYFEGTRCEVNKCSRCLQGACVVNKQTGDVTCNCTDGRVAPSCLTCIDHCSNGGSCTMNSKMMPECQCPPHMTGPRCEEQVVSQQQPGHMTSILIPLLLLLLLLLVAGVVFWYKRRVRGAKGFQHQRMTNGAMNVEIGNPTYKMYEGGEPDDVGGLLDADFALDPDKPTNFTNPVYATLYMGGHGSRHSLASTDEKRELLGRGPEDEIGDPLA", "length": 4545 }, "evidence": [ { "id": "FB:FBgn0053087", "url": "https://alliancegenome.org/gene/FB:FBgn0053087#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q07954-1", "protein_name": "Prolow-density lipoprotein receptor-related protein 1", "gene_name": "LRP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVVQGLEQPHGLVVHPLRGKLYWTDGDNISMANMDGSNRTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGRGQRACACAHGMLAEDGASCREYAGYLLYSERTILKSIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASICGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARNFMKTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVTNPCDRKKCEWLCLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTCNLQCFNGGSCFLNARRQPKCRCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTCRCPTGFTGPKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCENFGTCQMAADGSRQCRCTAYFEGSRCEVNKCSRCLEGACVVNKQSGDVTCNCTDGRVAPSCLTCVGHCSNGGSCTMNSKMMPECQCPPHMTGPRCEEHVFSQQQPGHIASILIPLLLLLLLVLVAGVVFWYKRRVQGAKGFQHQRMTNGAMNVEIGNPTYKMYEGGEPDDVGGLLDADFALDPDKPTNFTNPVYATLYMGGHGSRHSLASTDEKRELLGRGPEDEIGDPLA", "length": 4544 }, "evidence": [ { "id": "FB:FBgn0053087", "url": "https://alliancegenome.org/gene/FB:FBgn0053087#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q91ZX7-1", "protein_name": "Prolow-density lipoprotein receptor-related protein 1", "gene_name": "Lrp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLTPPLLLLLPLLSALVSGATMDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCPPNEHSCLGTELCVPMSRLCNGIQDCMDGSDEGAHCRELRANCSRMGCQHHCVPTPSGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFTCGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANTQQKTSVIRVNRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVAGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDTDGVTCLANPSYVPPPQCQPGEFACANNRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHSDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPNVKFGCKDSARCISKAWVCDGDSDCEDNSDEENCEALACRPPSHPCANNTSVCLPPDKLCDGKDDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGSDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTIHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGRGPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVVQGLEQPHGLVVHPLRGKLYWTDGDNISMANMDGSNHTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSELEVIDTMRSQLGKATALAIMGDKLWWADQVSEKMGTCNKADGSGSVVLRNSTTLVMHMKVYDESIQLEHEGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGHYPRIERSRLDGTERVVLVNVSISWPNGISVDYQGGKLYWCDARMDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHANGSIKRGCKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGGGQRACACAHGMLAEDGASCREYAGYLLYSERTILKSIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSGRTTIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNELHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKYVGSDMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQEDFTCRAVNSSCRAQDEFECANGECISFSLTCDGVSHCKDKSDEKPSYCNSRRCKKTFRQCNNGRCVSNMLWCNGVDDCGDGSDEIPCNKTACGVGEFRCRDGSCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDKEDDCENGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCTDGADESVTAGCLYNSTCDDREFMCQNRLCIPKHFVCDHDRDCADGSDESPECEYPTCGPNEFRCANGRCLSSRQWECDGENDCHDHSDEAPKNPHCTSPEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDGSDERGCHVNECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADLDECSTTFPCSQLCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSGRSIIVDTKITWPNGLTVDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGANKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGGDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFICPPNRPFRCKNDRVCLWIGRQCDGVDNCGDGTDEEDCEPPTAQNPHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASMCGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARNFMKTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQTFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLINLTGGLSHASDVVLYHQHKQPEVTNPCDRKKCEWLCLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTCTLQCFNGGSCFLNARRQPKCRCQPRYTGDKCELDQCWEYCHNGGTCAASPSGMPTCRCPTGFTGPKCTAQVCAGYCSNNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGFCENFGTCQMAADGSRQCRCTVYFEGPRCEVNKCSRCLQGACVVNKQTGDVTCNCTDGRVAPSCLTCIDHCSNGGSCTMNSKMMPECQCPPHMTGPRCEEQVVSQQQPGHMASILIPLLLLLLLLLVAGVVFWYKRRVRGAKGFQHQRMTNGAMNVEIGNPTYKMYEGGEPDDVGGLLDADFALDPDKPTNFTNPVYATLYMGGHGSRHSLASTDEKRELLGRGPEDEIGDPLA", "length": 4545 }, "evidence": [ { "id": "FB:FBgn0053087", "url": "https://alliancegenome.org/gene/FB:FBgn0053087#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9JI18-1", "protein_name": "Low-density lipoprotein receptor-related protein 1B", "gene_name": "Lrp1b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSQLLLAILTLSGLLPNAEVLIVGANQDQHLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDQSDESLDTCPEEVEIKCPLNHIACHGSSACVHLSKLCNGVVDCPDGFDEGGHCQELLPSCQQLNCQFKCAMVRNATRCYCEDGFEVAEDGRSCKDQDECSIYGICSQTCKNTYGSYACSCVEGYIMQSDNRSCKVKHEPTDKAPMLLISSLETIELFYINGSKMTTLSSANRNEIHTLDFIYSEEMICWIESRESSNQLKCGQITKAGRLTDQRIINSLQSFQNVEQMAFDWLTRNIYFVDHVSDRIFVCNFNGSVCVTLIESELHNPKAIAADPIAGKLFFTDYGNVPKIERCDLDGMNRTRIVYSKAEQPSALALDLVNRLVYWVDLYLDYVGVVDYQGKNRHTIVQGRQVKHLYGITVFEDYLYATSSDNFNIIRINRFNGTDIHSIIKMESARGIRTYQKRTQPTVRSHACEVDAYGMPGGCSHICLLSSSYKTRTCRCRTGFNMGSDGRSCKRPKNELFLFYGKGRPGIVRGMDLNTKIADECMIPIENLVNPRALDFHAEANYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGGMSHPRAIVVDPVNGWMYWTDWKEDKIDDSVGRIEKAWMDGVNRQVFVTSKMLWPNGLTLDFHTSTLYWCDAYYDHIEKVFLNGTHRKVVYSGKELNHPFGLSHHGNYVFWTDYMNGSIFQLDLMTNEVTLLRHERAPLFGLQIYDPRKQQGDNMCRINNGGCGTLCLAIPAGRVCACADNQLLDENGTTCTFNPEEIRFHICKPGEFRCKNKHCIQARWKCDGDDDCLDGSDEDSVTCFNHSCPDDQFKCQNNRCIPKRWLCDGANDCGSNEDESNQTCTARTCQADQFSCGNGRCIPTAWLCDREDDCGDQTDEVASCEFPTCEPLTQFICKSGRCISNKWHCDTDDDCGDRSDEVGCVHSCLDDQFRCSSGRCIPGHWACDGDNDCGDFSDETHINCTKEEARSPAGCIGNEFQCRPDGNCIPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCRSTGRCINNAWVCDGDVDCEDQSDEEDCDSFLCGPPKYPCANDTSVCLQPEKLCNGRKDCPDGSDEGDLCDECSLNNGGCSNHCSVVPGRGIVCSCPEGHQLKKDNRTCEIVDYCASHLRCSQVCEQQKHMVKCSCYEGWALGTDGESCTSVDSFEAFIIFSIRHEIRRIDLHKGDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVSKLDGSLRATLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFERRIVWTDARSDAIYSAFYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLAKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANEGRGPCSHLCLINHNRSAACACPHLMKLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYVNFITAFTVPDIDDVAVIDFDASEERLYWTDIKTQTITRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSIIHGIDKPQCLAAHPVRGKLYWTDGNTINMANMDGSNSKILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCNKRDGRNPSILRNKTSGVVHMKVYDKEAQQGSNSCQVNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGIESFLMYSVHEGIRGIPLEPRDKVDALMPISGAAFAVGIDFHAENDTIYWTDMGLNKISRAKRDQTWKEDVVTNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGFLFWTEWGQVPCIGKARLDGSEKVMIVSVGITWPNGISIDYEENKLYWCDARSDKIERIDLDTGANREVLLSGSNVDLFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETVTMRTGLGVNLKEIKIFNRVREKGTNVCAKENGGCQQLCLYRGNSRRTCACAHGYLAGDGVTCLRHEGYLLYSGRTILKSIHLSDETNLNSPVRPYENPNYFKNIIALAFDYNQRREGTNRIFYSDAHFGNIQLIKDNWEDRQVIVENVGSVEGLAYHRAWDTLYWTSSSTSSITRHTVDQTRPGAIDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQHPSIMRATLTGKNAHVVVSTDILTPNGLTIDHRAEKLYFSDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDSYIFWSDWGRRAILRSNKYTGGETKILRSDIPHQPMGIIAVANDTNSCELSPCALLNGGCHDLCLLTPDGRVNCSCRGDRVLLANNRCVTKNSSCNIYSEFECGNGDCVDYVLTCDGIPHCKDKSDEKLLYCENRSCRSGFKPCYNRRCVPHGKLCDGTNDCGDSSDELDCKVSTCSTVEFRCADGTCIPRSARCNQNMDCSDASDEKGCNNTDCTHFYKLGVKSTGFIRCNSTSLCVLPSWICDGSNDCGDYSDELKCPVQNKHKCEENYFGCPSGRCILNTWVCDGQKDCEDGLDELHCDSSCSWNQFACSVKKCISKHWICDGEDDCGDSLDESDSICGAVTCAADMFSCQGSHACVPQHWLCDGERDCPDGSDELSSAGCAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDEFLQCGYRQCGPEEFRCADGRCLVNTLWQCDGDFDCPDSSDEAPINPRCRSAEHSCNSSFFMCKNGRCIPSDGLCDIRDDCGDGSDETNCHINECLSKKISGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYKCHCAEGYETQPDNPNGCRSLSDEEPFLILADQHEIRKISTDGSNYTLLKQGLNNVIALDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTVLVSKRLKFPRDLSLDPRAGNLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNHRLYWADENHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRVHKTSGADRLSLINSWHAITDIQVYHSYRQPDVSKHLCTVNNGGCSHLCLLGPGKTHTCACPTNFYLAADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFKCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLAGQFKCTKNKKCIPVNLRCNGQDDCGDEEDEKDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNNCIPDHWRCDNQNDCSDNSDEDNCKPQTCTLKDFLCSNGDCVSSRFWCDGEFDCADGSDEKNCETSCSKDQFQCSNGQCLSAKWKCDGHEDCKYGEDEKNCEPAFPVCSSSEYMCASGGCLSASLKCNGEPDCVDGSDEMDCVIECKEDQFQCKNKAYCIPIRWLCDGIYDCVDGSDEETCGRGGSICRDDEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCPPTRPYRCRNDRICLQLEKICNGINDCGDNSDEEHCSGKLSLKSKPCKKDEFTCSNRNCIPMELQCDSLDDCGDGSDEQGCLKTPIEHTCENNGNPCGDDAYCNQIKTSVFCRCKPGFQRNMKGRECADLNECLLFGICSHHCLNTRGSYKCVCDQNFQEKNNSCIAKGSEDQALYIANDTDILGFVYPFNYSGGHQQISHVEHNSRITGMDVHYQRNVIVWSTQFNPGGIFYKMIDAREKRQANSGLICPEFKRPRDIAVDWVAGNVYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVIGDHSHIEEAAMDGTLRRVLVQKNLQRPTGLTVDHFGERIYWADFELSIIGSVLYDGSSPVVSVSSKQGLLHPHRIDVFEDYIYGAGPKNGIFRVQKFGHGSVEVLALGVDKTKSILVSHRYKQLNLPNPCLDLSCDFLCLLNPSGATCICPEGKYMMNGTCHDDSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSYSGGRCEVNHCSNYCQNGGTCIPSTLGRPTCICALGFTGPNCGKAVCEDSCHNGGSCVVTAGNQPYCHCQADYTGDRCQYYVCHHYCVNSESCTIGNDGSVECVCPTRYEGPKCEIDKCVRCHGGHCIINKDNEDIFCNCTNGKIASSCQLCDGYCYNGGTCQLDPETSIPVCVCSTNWSGTQCERPAPKSSKSEHISTRSIAIIVPLVLLVTLVTTLVIGLVVCKRKRRTKTIRRQPIINGGINVEIGNPSYNMYEVDHDHSDGGLLEPSFMIDPVKSRYIGGGSSAFKLPHTAPPIYLNSDLKGPLTFGPTNYSNPVYAKLYMDGQNCRNSLASVDERKELLPKKIEIGIRETVA", "length": 4599 }, "evidence": [ { "id": "HGNC:6693", "url": "https://alliancegenome.org/gene/HGNC:6693#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-070912-401", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070912-401#orthology", "database": "AGR" }, { "id": "MGI:2151136", "url": "https://alliancegenome.org/gene/MGI:2151136#orthology", "database": "AGR" }, { "id": "RGD:1306160", "url": "https://alliancegenome.org/gene/RGD:1306160#orthology", "database": "AGR" }, { "id": "FB:FBgn0053087", "url": "https://alliancegenome.org/gene/FB:FBgn0053087#orthology", "database": "AGR" }, { "id": "Q9NZR2", "url": "https://omabrowser.org/oma/group/Q9NZR2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q9NZR2", "url": "https://www.uniprot.org/uniprotkb/Q9NZR2" } ], "pmid": "" }, { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "Q9NZR2", "url": "https://www.uniprot.org/uniprotkb/Q9NZR2" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q9NZR2", "url": "https://www.uniprot.org/uniprotkb/Q9NZR2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q9NZR2", "url": "https://www.uniprot.org/uniprotkb/Q9NZR2" } ], "pmid": "" }, { "name": "receptor-mediated endocytosis", "id": "GO:0006898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006898", "evidence": [ { "database": "UniProtKB", "id": "Q9NZR2", "url": "https://www.uniprot.org/uniprotkb/Q9NZR2" } ], "pmid": "" }, { "name": "endocytosis", "id": "GO:0006897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "Q9NZR2", "url": "https://www.uniprot.org/uniprotkb/Q9NZR2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "Q9NZR2", "url": "https://www.uniprot.org/uniprotkb/Q9NZR2" } ], "pmid": "" }, { "name": "low-density lipoprotein particle receptor activity", "id": "GO:0005041", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005041", "evidence": [ { "database": "UniProtKB", "id": "Q9NZR2", "url": "https://www.uniprot.org/uniprotkb/Q9NZR2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1041, "end_pos": 1043, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1089, "end_pos": 1091, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1145, "end_pos": 1147, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1209, "end_pos": 1211, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1298, "end_pos": 1300, "annotation": "n_glycosylation_sequon" }, { "start_pos": 134, "end_pos": 136, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1502, "end_pos": 1504, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1549, "end_pos": 1551, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1636, "end_pos": 1638, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1754, "end_pos": 1756, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1816, "end_pos": 1818, "annotation": "n_glycosylation_sequon" }, { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1921, "end_pos": 1923, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1983, "end_pos": 1985, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2105, "end_pos": 2107, "annotation": "n_glycosylation_sequon" }, { "start_pos": 220, "end_pos": 222, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2458, "end_pos": 2460, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2488, "end_pos": 2490, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2507, "end_pos": 2509, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2549, "end_pos": 2551, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2626, "end_pos": 2628, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2647, "end_pos": 2649, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2802, "end_pos": 2804, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2892, "end_pos": 2894, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3034, "end_pos": 3036, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3066, "end_pos": 3068, "annotation": "n_glycosylation_sequon" }, 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