[ { "uniprot_canonical_ac": "Q96L73-1", "uniprot_ac": "Q96L73", "uniprot_id": "NSD1_HUMAN", "mass": { "chemical_mass": 296652.0, "monoisotopic_mass": 296652.0 }, "refseq": { "ac": "NP_071900", "name": "histone-lysine N-methyltransferase, H3 lysine-36 specific isoform b", "summary": "This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Sep 2018].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071900" }, "gene_names": [ { "name": "NSD1", "type": "recommended", "evidence": [ { "id": "Q96L73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ] }, { "name": "ARA267", "type": "synonym", "evidence": [ { "id": "NP_071900", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071900" }, { "id": "Q96L73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ] }, { "name": "KMT3B", "type": "synonym", "evidence": [ { "id": "NP_071900", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071900" }, { "id": "Q96L73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ] }, { "name": "NSD1", "type": "synonym", "evidence": [ { "id": "NP_071900", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071900" } ] }, { "name": "SOTOS1", "type": "synonym", "evidence": [ { "id": "NP_071900", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071900" } ] }, { "name": "SOTOS", "type": "synonym", "evidence": [ { "id": "NP_071900", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071900" } ] }, { "name": "STO", "type": "synonym", "evidence": [ { "id": "NP_071900", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071900" } ] } ], "protein_names": [ { "name": "Histone-lysine N-methyltransferase, H3 lysine-36 specific", "type": "recommended", "evidence": [ { "id": "Q96L73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96L73/entry#names_and_taxonomy" } ] }, { "name": "2.1.1.357", "type": "synonym", "evidence": [ { "id": "Q96L73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96L73/entry#names_and_taxonomy" } ] }, { "name": "Androgen receptor coactivator 267 kDa protein", "type": "synonym", "evidence": [ { "id": "Q96L73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96L73/entry#names_and_taxonomy" } ] }, { "name": "Androgen receptor-associated protein of 267 kDa", "type": "synonym", "evidence": [ { "id": "Q96L73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96L73/entry#names_and_taxonomy" } ] }, { "name": "H3-K36-HMTase", "type": "synonym", "evidence": [ { "id": "NP_071900", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071900" }, { "id": "Q96L73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96L73/entry#names_and_taxonomy" } ] }, { "name": "H4-K20-HMTase", "type": "synonym", "evidence": [ { "id": "NP_071900", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071900" } ] }, { "name": "Lysine N-methyltransferase 3B", "type": "synonym", "evidence": [ { "id": "Q96L73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96L73/entry#names_and_taxonomy" } ] }, { "name": "NR-binding SET domain-containing protein", "type": "synonym", "evidence": [ { "id": "NP_071900", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071900" }, { "id": "Q96L73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96L73/entry#names_and_taxonomy" } ] }, { "name": "Nuclear receptor-binding SET domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "Q96L73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96L73/entry#names_and_taxonomy" } ] }, { "name": "androgen receptor coactivator 267 kDa protein", "type": "synonym", "evidence": [ { "id": "NP_071900", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071900" } ] }, { "name": "androgen receptor-associated coregulator 267", "type": "synonym", "evidence": [ { "id": "NP_071900", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071900" } ] }, { "name": "androgen receptor-associated protein of 267 kDa", "type": "synonym", "evidence": [ { "id": "NP_071900", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071900" } ] }, { "name": "histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific", "type": "synonym", "evidence": [ { "id": "NP_071900", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071900" } ] }, { "name": "histone-lysine N-methyltransferase, H3 lysine-36 specific isoform b", "type": "synonym", "evidence": [ { "id": "NP_071900", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071900" } ] }, { "name": "histone-lysine N-methyltransferase, H3 lysine-36 specific", "type": "synonym", "evidence": [ { "id": "NP_071900", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071900" } ] }, { "name": "lysine N-methyltransferase 3B", "type": "synonym", "evidence": [ { "id": "NP_071900", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071900" } ] }, { "name": "nuclear receptor SET domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_071900", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071900" } ] }, { "name": "nuclear receptor-binding SET domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_071900", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071900" } ] } ], "function": [ { "annotation": "Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context.", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73#function" }, { "database": "PubMed", "id": "21196496", "url": "https://glygen.org/publication/PubMed/21196496" } ] }, { "annotation": "Identification of Novel NSD1 variations in four Pediatric cases with sotos Syndrome. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_071900", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071900" }, { "database": "PubMed", "id": "38684994", "url": "https://glygen.org/publication/PubMed/38684994" } ] }, { "annotation": "Impact of NSD1 Alternative Transcripts in Actin Filament Formation and Cellular Division Pathways in Fibroblasts. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_071900", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071900" }, { "database": "PubMed", "id": "39336709", "url": "https://glygen.org/publication/PubMed/39336709" } ] }, { "annotation": "This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Sep 2018].", "evidence": [ { "database": "RefSeq", "id": "NP_071900", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071900" } ] } ], "disease": [ { "disease_id": "DOID:0112103", "recommended_name": { "id": "DOID:0112103", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0112103", "name": "Sotos syndrome 1", "description": "A Sotos syndrome that has_material_basis_in heterozygous mutation in the NSD1 gene or deletion in the chromosome region 5q35 that includes the NSD1 gene." }, "synonyms": [ { "id": "DOID:0112103", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0112103", "name": "SOTOS1", "description": "" }, { "id": "MONDO:0019349", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019349", "name": "Sotos syndrome", "description": "Sotos syndrome is a rare multisystemic genetic disorder characterized by a typical facial appearance, overgrowth of the body in early life with macrocephaly, and mild to severe intellectual disability." }, { "id": "MONDO:0019349", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019349", "name": "NSD1 Sotos syndrome", "description": "" }, { "id": "MONDO:0019349", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019349", "name": "Sotos syndrome", "description": "" }, { "id": "MONDO:0019349", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019349", "name": "Sotos syndrome 1", "description": "" }, { "id": "MONDO:0019349", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019349", "name": "Sotos syndrome caused by mutation in NSD1", "description": "" }, { "id": "MONDO:0019349", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019349", "name": "Sotos syndrome type 1", "description": "" }, { "id": "MONDO:0019349", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019349", "name": "Sotos' syndrome", "description": "" }, { "id": "MONDO:0019349", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019349", "name": "cerebral gigantism", "description": "" }, { "id": "MONDO:0019349", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019349", "name": "cerebral gigantism syndrome", "description": "" }, { "id": "MONDO:0019349", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019349", "name": "chromosome 5q35 deletion syndrome", "description": "" }, { "id": "MONDO:0019349", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019349", "name": "SOTOS1", "description": "" }, { "id": "MONDO:0019349", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019349", "name": "distinctive facial appearance, overgrowth in childhood, and learning disabilities or delayed development", "description": "" }, { "id": "MIM:117550", "resource": "MIM", "url": "https://www.omim.org/entry/117550", "name": "Sotos syndrome", "description": "Sotos syndrome" } ], "unlinked_id_list": [], "evidence": [ { "id": "0112103", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0112103" }, { "id": "0112103", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0112103" } ] }, { "disease_id": "DOID:10907", "recommended_name": { "id": "DOID:10907", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10907", "name": "microcephaly", "description": "A congenital nervous system abnormality that is characterized by a significantly smaller than normal head in infants." }, "synonyms": [ { "id": "DOID:10907", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10907", "name": "Microcephalus", "description": "" }, { "id": "DOID:10907", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10907", "name": "microencephaly", "description": "" } ], "unlinked_id_list": [ "DOID:0061100" ], "evidence": [ { "id": "10907", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10907" } ] }, { "disease_id": "DOID:14748", "recommended_name": { "id": "DOID:14748", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:14748", "name": "Sotos syndrome", "description": "A syndrome that occurs rarely and is characterized by excessive physical growth during the first 2 to 3 years of life." }, "synonyms": [ { "id": "DOID:14748", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:14748", "name": "cerebral gigantism", "description": "" }, { "id": "MONDO:0019349", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019349", "name": "Sotos syndrome", "description": "Sotos syndrome is a rare multisystemic genetic disorder characterized by a typical facial appearance, overgrowth of the body in early life with macrocephaly, and mild to severe intellectual disability." }, { "id": "MONDO:0019349", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019349", "name": "NSD1 Sotos syndrome", "description": "" }, { "id": "MONDO:0019349", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019349", "name": "Sotos syndrome", "description": "" }, { "id": "MONDO:0019349", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019349", "name": "Sotos syndrome 1", "description": "" }, { "id": "MONDO:0019349", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019349", "name": "Sotos syndrome caused by mutation in NSD1", "description": "" }, { "id": "MONDO:0019349", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019349", "name": "Sotos syndrome type 1", "description": "" }, { "id": "MONDO:0019349", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019349", "name": "Sotos' syndrome", "description": "" }, { "id": "MONDO:0019349", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019349", "name": "cerebral gigantism", "description": "" }, { "id": "MONDO:0019349", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019349", "name": "cerebral gigantism syndrome", "description": "" }, { "id": "MONDO:0019349", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019349", "name": "chromosome 5q35 deletion syndrome", "description": "" }, { "id": "MONDO:0019349", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019349", "name": "SOTOS1", "description": "" }, { "id": "MONDO:0019349", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019349", "name": "distinctive facial appearance, overgrowth in childhood, and learning disabilities or delayed development", "description": "" }, { "id": "MIM:117550", "resource": "MIM", "url": "https://www.omim.org/entry/117550", "name": "Sotos syndrome", "description": "Sotos syndrome" } ], "unlinked_id_list": [], "evidence": [ { "id": "117550", "database": "MIM", "url": "https://www.omim.org/entry/117550" }, { "id": "14748", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:14748" } ] }, { "disease_id": "DOID:225", "recommended_name": { "id": "DOID:225", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:225", "name": "syndrome", "description": "A disease characterized by a group of signs and symptoms that occur together and characterize a particular abnormality." }, "synonyms": [], "unlinked_id_list": [ "DOID:0070656", "DOID:0111824", "DOID:0111655", "DOID:0112191" ], "evidence": [ { "id": "225", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:225" } ] }, { "disease_id": "DOID:5572", "recommended_name": { "id": "DOID:5572", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5572", "name": "Beckwith-Wiedemann syndrome", "description": "A syndrome characterized by overgrowth (macrosomia), an increased risk of childhood cancer and congenital malformations." }, "synonyms": [ { "id": "MONDO:0007534", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007534", "name": "Beckwith-Wiedemann syndrome", "description": "Beckwith-Wiedemann syndrome (BWS) is a genetic disorder characterized by overgrowth, tumor predisposition and congenital malformations." }, { "id": "MONDO:0007534", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007534", "name": "BWS", "description": "" }, { "id": "MONDO:0007534", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007534", "name": "Beckwith-Wiedemann syndrome", "description": "" }, { "id": "MONDO:0007534", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007534", "name": "Wiedemann-Beckwith syndrome", "description": "" }, { "id": "MONDO:0007534", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007534", "name": "exomphalos-macroglossia-gigantism syndrome", "description": "" }, { "id": "MONDO:0007534", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007534", "name": "Wiedemann-Beckwith syndrome (WBS)", "description": "" }, { "id": "MONDO:0007534", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007534", "name": "exomphalos macroglossia gigantism syndrome", "description": "" }, { "id": "MIM:130650", "resource": "MIM", "url": "https://www.omim.org/entry/130650", "name": "Beckwith-Wiedemann syndrome", "description": "Beckwith-Wiedemann syndrome" } ], "unlinked_id_list": [], "evidence": [ { "id": "5572", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5572" } ] }, { "disease_id": "DOID:769", "recommended_name": { "id": "DOID:769", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:769", "name": "neuroblastoma", "description": "An autonomic nervous system neoplasm that derives_from immature nerve cells." }, "synonyms": [], "unlinked_id_list": [], "evidence": [ { "id": "769", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:769" } ] }, { "disease_id": "DOID:9119", "recommended_name": { "id": "DOID:9119", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9119", "name": "acute myeloid leukemia", "description": "A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells." }, "synonyms": [ { "id": "DOID:9119", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9119", "name": "AML - acute Myeloid Leukemia", "description": "" }, { "id": "DOID:9119", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9119", "name": "Leukemia, Myelocytic, acute", "description": "" }, { "id": "DOID:9119", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9119", "name": "acute myeloblastic leukaemia", "description": "" }, { "id": "DOID:9119", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9119", "name": "acute myeloblastic leukemia", "description": "" }, { "id": "DOID:9119", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9119", "name": "acute myelogenous leukaemia", "description": "" }, { "id": "DOID:9119", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9119", "name": "acute myelogenous leukemia", "description": "" }, { "id": "DOID:9119", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9119", "name": "acute myeloid leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloid leukemia", "description": "Acute myeloid leukemia (AML) is a group of neoplasms arising from precursor cells committed to the myeloid cell-line differentiation. All of them are characterized by clonal expansion of myeloid blasts. AML manifests by fever, pallor, anemia, hemorrhages and recurrent infections." }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "AML", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "AML - acute myeloid leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "AML - acute myeloid leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "ANLL", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute Nonlymphocytic leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute Nonlymphocytic leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute granulocytic leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute granulocytic leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloblastic leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myelocytic leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myelocytic leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myelogenous leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myelogenous leukemias", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloid leukaemia (AML)", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloid leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloid leukemia (AML)", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloid leukemia, somatic", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute nonlymphocytic leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute nonlymphocytic leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "hematopoeitic - acute Myleogenous leukaemia (AML)", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "hematopoeitic - acute Myleogenous leukemia (AML)", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, acute myeloid, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, 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"MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute non lymphoblastic leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute non lymphoblastic leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, acute myeloid", "description": "" }, { "id": "MIM:601626", "resource": "MIM", "url": "https://www.omim.org/entry/601626", "name": "Leukemia, acute myelogenous", "description": "Leukemia, acute myelogenous" } ], "unlinked_id_list": [], "evidence": [ { "id": "9119", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9119" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 1914, "end_pos": 1914, "sequence_org": "R", "sequence_mut": "C", "comment": "Reduced enzyme activity.", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" }, { "database": "PubMed", "id": "21196496", "url": "https://glygen.org/publication/PubMed/21196496" } ] }, { "start_pos": 1952, "end_pos": 1952, "sequence_org": "R", "sequence_mut": "W", "comment": "Nearly abolished enzyme activity.", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" }, { "database": "PubMed", "id": "21196496", "url": "https://glygen.org/publication/PubMed/21196496" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "73.42", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000165671", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165671" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "76.94", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000165671", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165671" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "78.91", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000165671", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165671" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "49.96", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000165671", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165671" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "82.86", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000165671", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165671" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "85.01", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000165671", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165671" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "47.76", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000165671", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165671" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "77.49", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000165671", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165671" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "82.04", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000165671", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165671" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "47.6", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000165671", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165671" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "86.24", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000165671", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165671" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "80.92", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000165671", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165671" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "80.55", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000165671", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165671" } ] } ], "expression_disease": [ { "significant": "No", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "Q96L73", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q96L73" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] } ] }, { "significant": "No", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "Q96L73", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q96L73" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] } ] }, { "significant": "No", "trend": "down", "name": "Urinary bladder cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "Q96L73", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q96L73" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "11054", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11054" } ] } ] }, { "significant": "No", "trend": "down", "name": "Head and neck cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "Q96L73", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q96L73" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ], "unlinked_id_list": [ "DOID:1542" ], "evidence": [ { "id": "11934", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11934" } ] } ] }, { "significant": "No", "trend": "up", "name": "Lung cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "Q96L73", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q96L73" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": 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"575833", "url": "https://www.iedb.org/epitope/575833", "database": "IEDB", "categories": [ "Other" ] }, { "id": "577870", "url": "https://www.iedb.org/epitope/577870", "database": "IEDB", "categories": [ "Other" ] }, { "id": "581846", "url": "https://www.iedb.org/epitope/581846", "database": "IEDB", "categories": [ "Other" ] }, { "id": "619559", "url": "https://www.iedb.org/epitope/619559", "database": "IEDB", "categories": [ "Other" ] }, { "id": "623938", "url": "https://www.iedb.org/epitope/623938", "database": "IEDB", "categories": [ "Other" ] }, { "id": "624351", "url": "https://www.iedb.org/epitope/624351", "database": "IEDB", "categories": [ "Other" ] }, { "id": "624561", "url": "https://www.iedb.org/epitope/624561", "database": "IEDB", "categories": [ "Other" ] }, { "id": "624631", "url": "https://www.iedb.org/epitope/624631", "database": "IEDB", "categories": [ "Other" ] }, { "id": "699771", "url": "https://www.iedb.org/epitope/699771", "database": "IEDB", "categories": [ "Other" ] }, { "id": "712194", "url": "https://www.iedb.org/epitope/712194", "database": "IEDB", "categories": [ "Other" ] }, { "id": "715205", "url": "https://www.iedb.org/epitope/715205", "database": "IEDB", "categories": [ "Other" ] }, { "id": "715848", "url": "https://www.iedb.org/epitope/715848", "database": "IEDB", "categories": [ "Other" ] }, { "id": "717458", "url": "https://www.iedb.org/epitope/717458", "database": "IEDB", "categories": [ "Other" ] }, { "id": "778795", "url": "https://www.iedb.org/epitope/778795", "database": "IEDB", "categories": [ "Other" ] }, { "id": "837676", "url": "https://www.iedb.org/epitope/837676", "database": "IEDB", "categories": [ "Other" ] }, { "id": "881486", "url": "https://www.iedb.org/epitope/881486", "database": "IEDB", "categories": [ "Other" ] }, { "id": "931445", "url": "https://www.iedb.org/epitope/931445", "database": "IEDB", "categories": [ "Other" ] }, { "id": "932492", "url": "https://www.iedb.org/epitope/932492", "database": "IEDB", "categories": [ "Other" ] }, { "id": "950863", "url": "https://www.iedb.org/epitope/950863", "database": "IEDB", "categories": [ "Other" ] }, { "id": "Q96L73", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q96L73*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000313", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000313", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003616", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003616", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006560", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006560", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019786", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041306", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041306", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046341", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046341", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047423", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047423", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047426", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047426", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047428", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047428", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047429", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047429", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047430", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047430", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047432", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047432", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047433", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047433", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050777", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050777", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055197", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055197", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055198", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055198", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059153", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059153", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:64324", "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:64324", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "117550", "url": "http://www.omim.org/entry/117550", "database": "MIM", "categories": [ "Other" ] }, { "id": "130650", "url": "http://www.omim.org/entry/130650", "database": "MIM", "categories": [ "Other" ] }, { "id": "606681", "url": "http://www.omim.org/entry/606681", "database": "MIM", "categories": [ "Other" ] }, { "id": "Q96L73", "url": "https://oglcnac.org/atlas/detail/Q96L73", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "CTKTAES", "url": "https://omabrowser.org/oma/group/CTKTAES/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A1W2PS55", "url": "https://www.orthodb.org/?gene=A0A1W2PS55", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A2R8Y7J4", "url": "https://www.orthodb.org/?gene=A0A2R8Y7J4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A8I5KV31", "url": "https://www.orthodb.org/?gene=A0A8I5KV31", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A8I5QJP2", "url": "https://www.orthodb.org/?gene=A0A8I5QJP2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "D6RBP3", "url": "https://www.orthodb.org/?gene=D6RBP3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "D6RG26", "url": "https://www.orthodb.org/?gene=D6RG26", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "H7BYB0", "url": "https://www.orthodb.org/?gene=H7BYB0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q96L73", "url": "https://www.orthodb.org/?gene=Q96L73", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22884", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22884", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00003ooi", "url": "https://www.rcsb.org/structure/pdb_00003ooi", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00006kqp", "url": "https://www.rcsb.org/structure/pdb_00006kqp", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00006kqq", "url": "https://www.rcsb.org/structure/pdb_00006kqq", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00008c5l", "url": "https://www.rcsb.org/structure/pdb_00008c5l", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3OOI", "url": "https://www.rcsb.org/structure/3OOI", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6KQP", "url": "https://www.rcsb.org/structure/6KQP", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6KQQ", "url": "https://www.rcsb.org/structure/6KQQ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8C5L", "url": "https://www.rcsb.org/structure/8C5L", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00628", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00628", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF00855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00855", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF00856", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00856", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF17907", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17907", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF17982", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17982", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF22908", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22908", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF23004", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23004", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF23011", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23011", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "Q96L73", "url": "https://pharos.nih.gov/targets/Q96L73", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR:Q96L73", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:Q96L73", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-3214841", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3214841", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_071900", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071900", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "60308", "url": "https://www.rhea-db.org/rhea/60308", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A1W2PS55", "url": "https://www.uniprot.org/uniprotkb/A0A1W2PS55", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2PS55-1", "url": "https://www.uniprot.org/uniprotkb/A0A1W2PS55-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2R8Y7J4", "url": "https://www.uniprot.org/uniprotkb/A0A2R8Y7J4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2R8Y7J4-1", "url": "https://www.uniprot.org/uniprotkb/A0A2R8Y7J4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5KV31", "url": "https://www.uniprot.org/uniprotkb/A0A8I5KV31", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5KV31-1", "url": "https://www.uniprot.org/uniprotkb/A0A8I5KV31-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5QJP2", "url": "https://www.uniprot.org/uniprotkb/A0A8I5QJP2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5QJP2-1", "url": "https://www.uniprot.org/uniprotkb/A0A8I5QJP2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6RBP3", "url": "https://www.uniprot.org/uniprotkb/D6RBP3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6RBP3-1", "url": "https://www.uniprot.org/uniprotkb/D6RBP3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6RG26", "url": "https://www.uniprot.org/uniprotkb/D6RG26", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6RG26-1", "url": "https://www.uniprot.org/uniprotkb/D6RG26-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H7BYB0", "url": "https://www.uniprot.org/uniprotkb/H7BYB0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H7BYB0-1", "url": "https://www.uniprot.org/uniprotkb/H7BYB0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q96L73-1", "url": "https://www.uniprot.org/uniprotkb/Q96L73-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q96L73-2", "url": "https://www.uniprot.org/uniprotkb/Q96L73-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q96L73-3", "url": "https://www.uniprot.org/uniprotkb/Q96L73-3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGSADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESIEEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQLNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLNFISGDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAKKEFETSNGDSLLGLPEGALISKCSREKNKPQRSLVCGSKVKLCYIGAGDEEKRSDSISICTTSDDGSSDLDPIEHSSESDNSVLEIPDAFDRTENMLSMQKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCTKSAEPGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFNLSSSISSENSLIKGGAANQALLHSKSKQPKFRSIKCKHKENPVMAEPPVINEECSLKCCSSDTKGSPLASISKSGKVDGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHIPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPSPSGGDSALSGELSASLPGLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSKLRDAFSAQMVKNTVNRKALKTERKRKLNQLPSVTLDAVLQGDRERGGSLRGGAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDPGKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQRRTKPRKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEHRTPSASILEEPLTEQNHADCLDSAGPRLNVCDKSSASIGDMEKEPGIPSLTPQAELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLLARGRSSAQNKQVDENSLISTKEEPPVLEREAPFLEGPLAQSELGGGHAELPQLTLSVPVAPEVSPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLSKKCYEAGHLENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRHAAAKMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMPASKKMQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIREYVPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQMLSLSKKALAGTCQRPLLPERPLERTDSRPQPLDKVRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRPQLSDKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTSVPTGLRLPPPDRLLITSSPKPQTSDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQSKNRAALVMDLIDLTPRQKERAASPHQVTPQADEKMPVLESSSWPASKGLGHMPRAVEKGCVSDPLQTSGKAAAPSEDPWQAVKSLTQARLLSQPPAKAFLYEPTTQASGRASAGAEQTPGPLSQSPGLVKQAKQMVGGQQLPALAAKSGQSFRSLGKAPASLPTEEKKLVTTEQSPWALGKASSRAGLWPIVAGQTLAQSCWSAGSTQTLAQTCWSLGRGQDPKPEQNTLPALNQAPSSHKCAESEQK", "length": 2696, "header": "sp|Q96L73-1|NSD1_HUMAN Isoform 1 of Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Homo sapiens OX=9606 GN=NSD1 PE=1 SV=1 CANONICAL=Q96L73-1" }, "isoforms": [ { "isoform_ac": "A0A1W2PS55-1", "url": "https://www.uniprot.org/uniprotkb/Q96L73/entry#A0A1W2PS55-1", "sequence": { "sequence": "MKVSNRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLNFISGDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAKKEFETSNGDSLLGLPEGALISKCSREKNKPQRSLVCGSKVKLCYIGAGDEEKRSDSISICTTSDDGSSDLDPIEHSSESDNSVLEIPDAFDRTENMLSMQKNEKI", "length": 332, "header": "tr|A0A1W2PS55-1|NSD1_HUMAN Computationally mapped isoform of Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Homo sapiens OX=9606 GN=NSD1 PE=1 SV=3 CANONICAL=Q96L73-1" }, "locus": { "chromosome": "5", "start_pos": 177210451, "end_pos": 177192013, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000638627.3", "url": "https://www.ensembl.org/id/ENST00000638627.3" }, { "database": "Ensembl Peptide", "id": "ENSP00000492679.3", "url": "https://www.ensembl.org/id/ENSP00000492679.3" } ] } }, { "isoform_ac": "A0A2R8Y7J4-1", "url": "https://www.uniprot.org/uniprotkb/Q96L73/entry#A0A2R8Y7J4-1", "sequence": { "sequence": "MKVSNRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLNFISGDISDTQASNELSRIAN", "length": 204, "header": "tr|A0A2R8Y7J4-1|A0A2R8Y7J4_HUMAN Computationally mapped isoform of Nuclear receptor binding SET domain protein 1 OS=Homo sapiens OX=9606 GN=NSD1 PE=1 SV=1 CANONICAL=Q96L73-1" }, "locus": { "chromosome": "5", "start_pos": 177210067, "end_pos": 177192013, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000644863.2", "url": "https://www.ensembl.org/id/ENST00000644863.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000496157.2", "url": "https://www.ensembl.org/id/ENSP00000496157.2" } ] } }, { "isoform_ac": "A0A8I5KV31-1", "url": "https://www.uniprot.org/uniprotkb/Q96L73/entry#A0A8I5KV31-1", "sequence": { "sequence": "MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGSADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESIEEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQLNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLNFISGDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAKKEFETSNGDSLLGLPEGALISKCSREKNKPQRSLVCGSKVKLCYIGAGDEEKRSDSISICTTSDDGSSDLDPIEHSSESDNSVLEIPDAFDRTENMLSMQKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCTKSAEPGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFNLSSSISSENSLIKGGAANQALLHSKSKQPKFRSIKCKHKENPVMAEPPVINEECSLKCCSSDTKGSPLASISKSGKVDGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHIPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPSPSGGDSALSGELSASLPGLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSKLRDAFSAQMVKNTVNRKALKTERKRKLNQLPSVTLDAVLQGDRERGGSLRGGAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDPGKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQRRTKPRKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEHRTPSASILEEPLTEQNHADCLDSAGPRLNVCDKSSASIGDMEKEPGIPSLTPQAELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKEIMKVNVKENQLRNFLNPMI", "length": 1327, "header": "tr|A0A8I5KV31-1|A0A8I5KV31_HUMAN Computationally mapped isoform of Nuclear receptor binding SET domain protein 1 OS=Homo sapiens OX=9606 GN=NSD1 PE=1 SV=1 CANONICAL=Q96L73-1" }, "locus": { "chromosome": "5", "start_pos": 177239815, "end_pos": 177135104, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000689326.1", "url": "https://www.ensembl.org/id/ENST00000689326.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000509594.1", "url": "https://www.ensembl.org/id/ENSP00000509594.1" } ] } }, { "isoform_ac": "A0A8I5QJP2-1", "url": "https://www.uniprot.org/uniprotkb/Q96L73/entry#A0A8I5QJP2-1", "sequence": { "sequence": "MLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLNFISGDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAKKEFETSNGDSLLGLPEGALISKCSREKNKPQRSLVCGSKVKLCYIGAGDEEKRSDSISICTTSDDGSSDLDPIEHSSESDNSVLEIPDAFDRTENMLSMQKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCTKSAEPGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFNLSSSISSENSLIKGGAANQALLHSKSKQPKFRSIKCKHKENPVMAEPPVINEECSLKCCSSDTKGSPLASISKSGKVDGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHIPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPSPSGGDSALSGELSASLPGLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSKLRDAFSAQMVKNTVNRKALKTERKRKLNQLPSVTLDAVLQGDRERGGSLRGGAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDPGKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQRRTKPRKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEHRTPSASILEEPLTEQNHADCLDSAGPRLNVCDKSSASIGDMEKEPGIPSLTPQAELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLLARGRSSAQNKQVDENSLISTKEEPPVLEREAPFLEGPLAQSELGGGHAELPQLTLSVPVAPEVSPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLSKKCYEAGHLENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRHAAAKMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMPASKKMQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIREYVPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQMLSLSKKALAGTCQRPLLPERPLERTDSRPQPLDKVRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRPQLSDKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTSVPTGLRLPPPDRLLITSSPKPQTSDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQSKNRAALVMDLIDLTPRQKERAASPHQVTPQADEKMPVLESSSWPASKGLGHMPRAVEKGCVSDPLQTSGKAAAPSEDPWQAVKSLTQARLLSQPPAKAFLYEPTTQASGRASAGAEQTPGPLSQSPGLVKQAKQMVGGQQLPALAAKSGQSFRSLGKAPASLPTEEKKLVTTEQSPWALGKASSRAGLWPIVAGQTLAQSCWSAGSTQTLAQTCWSLGRGQDPKPEQNTLPALNQAPSSHKCAESEQK", "length": 2405, "header": "tr|A0A8I5QJP2-1|A0A8I5QJP2_HUMAN Computationally mapped isoform of Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Homo sapiens OX=9606 GN=NSD1 PE=1 SV=1 CANONICAL=Q96L73-1" }, "locus": { "chromosome": "5", "start_pos": 177295456, "end_pos": 177135977, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000686993.1", "url": "https://www.ensembl.org/id/ENST00000686993.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000510020.1", "url": "https://www.ensembl.org/id/ENSP00000510020.1" } ] } }, { "isoform_ac": "D6RBP3-1", "url": "https://www.uniprot.org/uniprotkb/Q96L73/entry#D6RBP3-1", "sequence": { "sequence": "MRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIREYVPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQMLSLSKKALAGTCQRPLLPERPLERTDSRPQPLDKVRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRPQLSDKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTSVPTGLRLPPPDRLLITSSPKPQTSDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQSKNRAALVMDLIDLTPRQKERAASPHQVTPQADEKMPVLESSSWPASKGLGHMPRAVEKGCVSDPLQTSGKAAAPSEDPWQAVKSLTQARLLSQPPAKAFLYEPTTQASGRASAGAEQTPGPLSQSPGLVKQAKQMVGGQQLPALAAKSGQSFRSLGKAPASLPTEEKKLVTTEQSPWALGKASSRAGLWPIVAGQTLAQSCWSAGSTQTLAQTCWSLGRGQDPKPEQNTLPALNQAPSSHKCAESEQK", "length": 910, "header": "tr|D6RBP3-1|NSD1_HUMAN Computationally mapped isoform of Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Homo sapiens OX=9606 GN=NSD1 PE=1 SV=2 CANONICAL=Q96L73-1" }, "locus": { "chromosome": "5", "start_pos": 177295456, "end_pos": 177269657, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000508029.6", "url": "https://www.ensembl.org/id/ENST00000508029.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000425120.2", "url": "https://www.ensembl.org/id/ENSP00000425120.2" } ] } }, { "isoform_ac": "D6RG26-1", "url": "https://www.uniprot.org/uniprotkb/Q96L73/entry#D6RG26-1", "sequence": { "sequence": "MLELPGTSSSSTSQELPFRLALSCCPGWRRDSWAHSILLHQLELQ", "length": 45, "header": "tr|D6RG26-1|NSD1_HUMAN Computationally mapped isoform of Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Homo sapiens OX=9606 GN=NSD1 PE=1 SV=2 CANONICAL=Q96L73-1" }, "locus": { "chromosome": "5", "start_pos": 177136953, "end_pos": 177135977, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000511258.6", "url": "https://www.ensembl.org/id/ENST00000511258.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000426428.2", "url": "https://www.ensembl.org/id/ENSP00000426428.2" } ] } }, { "isoform_ac": "H7BYB0-1", "url": "https://www.uniprot.org/uniprotkb/Q96L73/entry#H7BYB0-1", "sequence": { "sequence": "DKSSASIGDMEKEPGIPSLTPQAELPEPGGVLLCHPGWSAVARSRLTATSASQVQVILLSHPPE", "length": 64, "header": "tr|H7BYB0-1|H7BYB0_HUMAN Computationally mapped isoform of Nuclear receptor binding SET domain protein 1 OS=Homo sapiens OX=9606 GN=NSD1 PE=1 SV=1 CANONICAL=Q96L73-1" }, "locus": { "chromosome": "5", "start_pos": 177229871, "end_pos": 177212111, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000375350.3", "url": "https://www.ensembl.org/id/ENST00000375350.3" }, { "database": "Ensembl Peptide", "id": "ENSP00000364499.3", "url": "https://www.ensembl.org/id/ENSP00000364499.3" } ] } }, { "isoform_ac": "Q96L73-1", "url": "https://www.uniprot.org/uniprotkb/Q96L73/entry#Q96L73-1", "sequence": { "sequence": "MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGSADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESIEEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQLNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLNFISGDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAKKEFETSNGDSLLGLPEGALISKCSREKNKPQRSLVCGSKVKLCYIGAGDEEKRSDSISICTTSDDGSSDLDPIEHSSESDNSVLEIPDAFDRTENMLSMQKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCTKSAEPGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFNLSSSISSENSLIKGGAANQALLHSKSKQPKFRSIKCKHKENPVMAEPPVINEECSLKCCSSDTKGSPLASISKSGKVDGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHIPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPSPSGGDSALSGELSASLPGLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSKLRDAFSAQMVKNTVNRKALKTERKRKLNQLPSVTLDAVLQGDRERGGSLRGGAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDPGKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQRRTKPRKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEHRTPSASILEEPLTEQNHADCLDSAGPRLNVCDKSSASIGDMEKEPGIPSLTPQAELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLLARGRSSAQNKQVDENSLISTKEEPPVLEREAPFLEGPLAQSELGGGHAELPQLTLSVPVAPEVSPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLSKKCYEAGHLENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRHAAAKMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMPASKKMQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIREYVPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQMLSLSKKALAGTCQRPLLPERPLERTDSRPQPLDKVRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRPQLSDKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTSVPTGLRLPPPDRLLITSSPKPQTSDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQSKNRAALVMDLIDLTPRQKERAASPHQVTPQADEKMPVLESSSWPASKGLGHMPRAVEKGCVSDPLQTSGKAAAPSEDPWQAVKSLTQARLLSQPPAKAFLYEPTTQASGRASAGAEQTPGPLSQSPGLVKQAKQMVGGQQLPALAAKSGQSFRSLGKAPASLPTEEKKLVTTEQSPWALGKASSRAGLWPIVAGQTLAQSCWSAGSTQTLAQTCWSLGRGQDPKPEQNTLPALNQAPSSHKCAESEQK", "length": 2696, "header": "sp|Q96L73-1|NSD1_HUMAN Isoform 1 of Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Homo sapiens OX=9606 GN=NSD1 PE=1 SV=1 CANONICAL=Q96L73-1" }, "locus": { "chromosome": "5", "start_pos": 177295456, "end_pos": 177135104, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000439151.7", "url": "https://www.ensembl.org/id/ENST00000439151.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000395929.2", "url": "https://www.ensembl.org/id/ENSP00000395929.2" } ] } }, { "isoform_ac": "Q96L73-2", "url": "https://www.uniprot.org/uniprotkb/Q96L73/entry#Q96L73-2", "sequence": { "sequence": "MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLNFISGDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAKKEFETSNGDSLLGLPEGALISKCSREKNKPQRSLVCGSKVKLCYIGAGDEEKRSDSISICTTSDDGSSDLDPIEHSSESDNSVLEIPDAFDRTENMLSMQKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCTKSAEPGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFNLSSSISSENSLIKGGAANQALLHSKSKQPKFRSIKCKHKENPVMAEPPVINEECSLKCCSSDTKGSPLASISKSGKVDGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHIPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPSPSGGDSALSGELSASLPGLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSKLRDAFSAQMVKNTVNRKALKTERKRKLNQLPSVTLDAVLQGDRERGGSLRGGAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDPGKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQRRTKPRKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEHRTPSASILEEPLTEQNHADCLDSAGPRLNVCDKSSASIGDMEKEPGIPSLTPQAELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLLARGRSSAQNKQVDENSLISTKEEPPVLEREAPFLEGPLAQSELGGGHAELPQLTLSVPVAPEVSPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLSKKCYEAGHLENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRHAAAKMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMPASKKMQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIREYVPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQMLSLSKKALAGTCQRPLLPERPLERTDSRPQPLDKVRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRPQLSDKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTSVPTGLRLPPPDRLLITSSPKPQTSDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQSKNRAALVMDLIDLTPRQKERAASPHQVTPQADEKMPVLESSSWPASKGLGHMPRAVEKGCVSDPLQTSGKAAAPSEDPWQAVKSLTQARLLSQPPAKAFLYEPTTQASGRASAGAEQTPGPLSQSPGLVKQAKQMVGGQQLPALAAKSGQSFRSLGKAPASLPTEEKKLVTTEQSPWALGKASSRAGLWPIVAGQTLAQSCWSAGSTQTLAQTCWSLGRGQDPKPEQNTLPALNQAPSSHKCAESEQK", "length": 2427, "header": "sp|Q96L73-2|NSD1_HUMAN Isoform 2 of Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Homo sapiens OX=9606 GN=NSD1 PE=1 SV=1 CANONICAL=Q96L73-1" }, "locus": {} }, { "isoform_ac": "Q96L73-3", "url": "https://www.uniprot.org/uniprotkb/Q96L73/entry#Q96L73-3", "sequence": { "sequence": "MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGSADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESIEEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQLNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLNFISGDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAKKEFETSNGDSLLGLPEGALISKCSREKNKPQRSLVCGSKVKLCYIGAGDEEKRSDSISICTTSDDGSSDLDPIEHSSESDNSVLEIPDAFDRTENMLSMQKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCTKSAEPGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFNLSSSISSENSLIKGGAANQALLHSKSKQPKFRSIKCKHKENPVMAEPPVINEECSLKCCSSDTKGSPLASISKSGKVDGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHIPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPSPSGGDSALSGELSASLPGLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSKLRDAFSAQMVKNTVNRKALKTERKRKLNQLPSVTLDAVLQGDRERGGSLRGGAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDPGKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQRRTKPRKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEHRTPSASILEEPLTEQNHADCLDSAGPRLNVCDKSSASIGDMEKEPGIPSLTPQAELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLLARGRSSAQNKQVDENSLISTKEEPPVLEREAPFLEGPLAQSELGGGHAELPQLTLSVPVAPEVSPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLSKKCYEAGHLENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRHAAAKMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMPASKKMQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIREYVPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQMLSLSKKALAGTCQRPLLPERPLERTDSRPQPLDKVRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRPQLSDKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTSVPTGLRLPPPDRLLITSSPKPQTSDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQSKNRAALVMDLIDLTPRQKERAASPHQVTPQADEKMPVLESSSWPASKGLGHMPRAVEKGCVSDPLQTSGKAAAPSEDPWQAVKSLTQARLLSQPPAKAFLYEPTTQASGRASAGAEQTPGPLSQSPGLVKQAKQMVGGQQLPALAAKSGQSFRSLGKAPASLPTEEKKLVTTEQSPWALGKASSRAGLWPIVAGQTLAQSCWSAGSTQTLAQTCWSLGRGQDPKPEQNTLPALNQAPSSHKCAESEQK", "length": 2593, "header": "sp|Q96L73-3|NSD1_HUMAN Isoform 3 of Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Homo sapiens OX=9606 GN=NSD1 PE=1 SV=1 CANONICAL=Q96L73-1" }, "locus": { "chromosome": "5", "start_pos": 177295456, "end_pos": 177135104, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000687453.1", "url": "https://www.ensembl.org/id/ENST00000687453.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000508426.1", "url": "https://www.ensembl.org/id/ENSP00000508426.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_pos": 1017, "start_aa": "Thr", "end_pos": 1017, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1017", "evidence": [ { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "Q96L73", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q96L73" }, { "id": "Q96L73", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q96L73" } ], "filter_code": "00000000000000001000.0000000.00000001000000.1000000.0100000000.110100100001111011.10000.01001" }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_pos": 1035, "start_aa": "Ser", "end_pos": 1035, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser1035", "evidence": [ { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "Q96L73", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q96L73" }, { "id": "Q96L73", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q96L73" } ], "filter_code": "00000000000000010000.0000000.00000001000000.1000000.0100000000.110100100001111011.10000.01001" } ], "phosphorylation": [ { "start_pos": 1024, "end_pos": 1024, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q96L73", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q96L73" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser1024" }, { "start_pos": 1027, "end_pos": 1027, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q96L73", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q96L73" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser1027" }, { "start_pos": 117, "end_pos": 117, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "site_lbl": "Ser117" }, { "start_pos": 1338, "end_pos": 1338, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q96L73", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q96L73" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Thr1338" }, { "start_pos": 1510, "end_pos": 1510, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "site_lbl": "Ser1510" }, { "start_pos": 2109, "end_pos": 2109, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q96L73", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q96L73" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Thr2109" }, { "start_pos": 217, "end_pos": 217, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q96L73", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q96L73" }, { "database": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser217" }, { 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Kearney L, Boultwood J, Wainscoat JS", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "reference": [ { "type": "PubMed", "id": "11493482", "url": "https://glygen.org/publication/PubMed/11493482" } ] }, { "title": "Identification and characterization of a novel androgen receptor coregulator ARA267-alpha in prostate cancer cells.", "journal": "J. Biol. Chem.", "date": "2001", "authors": "Wang X, Yeh S, Wu G, Hsu C L, Wang L, Chiang T, Yang Y, Guo Y, Chang C", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "reference": [ { "type": "PubMed", "id": "11509567", "url": "https://glygen.org/publication/PubMed/11509567" } ] }, { "title": "Molecular characterization of NSD1, a human homologue of the mouse Nsd1 gene.", "journal": "Gene", "date": "2001", "authors": "Kurotaki N, Harada N, Yoshiura K, Sugano S, Niikawa N, Matsumoto N", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "reference": [ { "type": "PubMed", "id": "11733144", "url": "https://glygen.org/publication/PubMed/11733144" } ] }, { "title": "Haploinsufficiency of NSD1 causes Sotos syndrome.", "journal": "Nat. Genet.", "date": "2002", "authors": "Kurotaki Naohiro, Imaizumi Kiyoshi, Harada Naoki, Masuno Mitsuo, Kondoh Tatsuro, Nagai Toshiro, Ohashi Hirofumi, Naritomi Kenji, Tsukahara Masato, Makita Yoshio, Sugimoto Tateo, Sonoda Tohru, Hasegawa Tomoko, Chinen Yasuaki, Tomita Ha Hiro-aki, Kinoshita Akira, Mizuguchi Tsuyoshi, Yoshiura Ki Koh-ichiro, Ohta Tohru, Kishino Tatsuya, Fukushima Yoshimitsu, Niikawa Norio, Matsumoto Naomichi", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "reference": [ { "type": "PubMed", "id": "11896389", "url": "https://glygen.org/publication/PubMed/11896389" } ] }, { "title": "SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.", "journal": "Genes & development", "date": "2002", "authors": "Schultz DC, Ayyanathan K, Negorev D, Maul GG, Rauscher FJ 3rd", "evidence": [ { "database": 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Temple IK, Davies S, Murray A, Upadhyaya M, Tomkins S, Hughes HE, Cole TR, Rahman N", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "reference": [ { "type": "PubMed", "id": "12464997", "url": "https://glygen.org/publication/PubMed/12464997" } ] }, { "title": "Structure and catalytic mechanism of the human histone methyltransferase SET7/9.", "journal": "Nature", "date": "2003", "authors": "Xiao B, Jing C, Wilson JR, Walker PA, Vasisht N, Kelly G, Howell S, Taylor IA, Blackburn GM, Gamblin SJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-3214841", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3214841" } ], "reference": [ { "type": "PubMed", "id": "12540855", "url": "https://glygen.org/publication/PubMed/12540855" } ] }, { "title": "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.", "journal": 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"journal": "eLife", "date": "2015-07-08", "authors": "Caron Etienne, Espona Lucia, Kowalewski Daniel J, Schuster Heiko, Ternette Nicola, Alp\u00edzar Ad\u00e1n, Schittenhelm Ralf B, Ramarathinam Sri H, Lindestam Arlehamn Cecilia S, Chiek Koh Ching, Gillet Ludovic C, Rabsteyn Armin, Navarro Pedro, Kim Sangtae, Lam Henry, Sturm Theo, Marcilla Miguel, Sette Alessandro, Campbell David S, Deutsch Eric W, Moritz Robert L, Purcell Anthony W, Rammensee Hans-Georg, Stevanovic Stefan, Aebersold Ruedi", "evidence": [ { "database": "IEDB", "id": "224791", "url": "https://www.iedb.org/epitope/224791" }, { "database": "IEDB", "id": "446544", "url": "https://www.iedb.org/epitope/446544" } ], "reference": [ { "type": "PubMed", "id": "26154972", "url": "https://glygen.org/publication/PubMed/26154972" } ] }, { "title": "Comprehensive Analysis of the Naturally Processed Peptide Repertoire: Differences between HLA-A and B in the Immunopeptidome.", "journal": "PloS one", "date": "2015", "authors": "Schellens Ingrid M M, Hoof Ilka, Meiring Hugo D, Spijkers Sanne N M, Poelen Martien C M, van Gaans-van den Brink Jacqueline A M, van der Poel Kees, Costa Ana I, van Els Cecile A C M, van Baarle Debbie, Kesmir Can", "evidence": [ { "database": "IEDB", "id": "224791", "url": "https://www.iedb.org/epitope/224791" }, { "database": "IEDB", "id": "439940", "url": "https://www.iedb.org/epitope/439940" } ], "reference": [ { "type": "PubMed", "id": "26375851", "url": "https://glygen.org/publication/PubMed/26375851" } ] }, { "title": "High-sensitivity HLA class I peptidome analysis enables a precise definition of peptide motifs and the identification of peptides from cell lines and patients' sera.", "journal": "Proteomics", "date": "2016-05", "authors": "Ritz Danilo, Gloger Andreas, Weide Benjamin, Garbe Claus, Neri Dario, Fugmann Tim", "evidence": [ { "database": "IEDB", "id": "224791", "url": "https://www.iedb.org/epitope/224791" }, { "database": "IEDB", "id": "506550", "url": "https://www.iedb.org/epitope/506550" }, { "database": "IEDB", "id": "619559", "url": "https://www.iedb.org/epitope/619559" }, { "database": "IEDB", "id": "623938", "url": "https://www.iedb.org/epitope/623938" }, { "database": "IEDB", "id": "624561", "url": "https://www.iedb.org/epitope/624561" }, { "database": "IEDB", "id": "624631", "url": "https://www.iedb.org/epitope/624631" } ], "reference": [ { "type": "PubMed", "id": "26992070", "url": "https://glygen.org/publication/PubMed/26992070" } ] }, { "title": "A large fraction of HLA class I ligands are proteasome-generated spliced peptides.", "journal": "Science (New York, N.Y.)", "date": "2016-10-21", "authors": "Liepe Juliane, Marino Fabio, Sidney John, Jeko Anita, Bunting Daniel E, Sette Alessandro, Kloetzel Peter M, Stumpf Michael P H, Heck Albert J R, Mishto Michele", "evidence": [ { "database": "IEDB", "id": "581846", "url": "https://www.iedb.org/epitope/581846" } ], "reference": [ { "type": "PubMed", "id": "27846572", "url": "https://glygen.org/publication/PubMed/27846572" } ] }, { "title": "The Intergenic Recombinant HLA-B *46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands.", "journal": "Cell reports", "date": "2017", "authors": "Hilton HG, McMurtrey CP, Han AS, Djaoud Z, Guethlein LA, Blokhuis JH, Pugh JL, Goyos A, Horowitz A, Buchli R, Jackson KW, Bardet W, Bushnell DA, Robinson PJ, Mendoza JL, Birnbaum ME, Nielsen M, Garcia KC, Hildebrand WH, Parham P", "evidence": [ { "database": "IEDB", "id": "623938", "url": "https://www.iedb.org/epitope/623938" } ], "reference": [ { "type": "PubMed", "id": "28514659", "url": "https://glygen.org/publication/PubMed/28514659" } ] }, { "title": "Deciphering HLA-I motifs across HLA peptidomes improves neo-antigen predictions and identifies allostery regulating HLA specificity.", "journal": "PLoS computational biology", "date": "2017-08", "authors": "Bassani-Sternberg Michal, Chong Chlo\u00e9, Guillaume Philippe, Solleder Marthe, Pak HuiSong, Gannon Philippe O, Kandalaft Lana E, Coukos George, Gfeller David", "evidence": [ { "database": "IEDB", "id": "224791", "url": "https://www.iedb.org/epitope/224791" }, { "database": "IEDB", "id": "717458", "url": "https://www.iedb.org/epitope/717458" } ], "reference": [ { "type": "PubMed", "id": "28832583", "url": "https://glygen.org/publication/PubMed/28832583" } ] }, { "title": "Unveiling the Peptide Motifs of HLA-C and HLA-G from Naturally Presented Peptides and Generation of Binding Prediction Matrices.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2017-10-15", "authors": "Di Marco Moreno, Schuster Heiko, Backert Linus, Ghosh Michael, Rammensee Hans-Georg, Stevanovi\u0107 Stefan", "evidence": [ { "database": "IEDB", "id": "712194", "url": "https://www.iedb.org/epitope/712194" }, { "database": "IEDB", "id": "715205", "url": "https://www.iedb.org/epitope/715205" }, { "database": "IEDB", "id": "715848", "url": "https://www.iedb.org/epitope/715848" } ], "reference": [ { "type": "PubMed", "id": "28904123", "url": "https://glygen.org/publication/PubMed/28904123" } ] }, { "title": "High-throughput and Sensitive Immunopeptidomics Platform Reveals Profound Interferon\u03b3-Mediated Remodeling of the Human Leukocyte Antigen (HLA) Ligandome.", "journal": "Molecular & cellular proteomics : MCP", "date": "2018-03", "authors": "Chong Chloe, Marino Fabio, Pak HuiSong, Racle Julien, Daniel Roy T, M\u00fcller Markus, Gfeller David, Coukos George, Bassani-Sternberg Michal", "evidence": [ { "database": "IEDB", "id": "224791", "url": "https://www.iedb.org/epitope/224791" }, { "database": "IEDB", "id": "717458", "url": "https://www.iedb.org/epitope/717458" } ], "reference": [ { "type": "PubMed", "id": "29242379", "url": "https://glygen.org/publication/PubMed/29242379" } ] }, { "title": "T-Cell Immunopeptidomes Reveal Cell Subtype Surface Markers Derived From Intracellular Proteins.", "journal": "Proteomics", "date": "2018-06", "authors": "Olsson Niclas, Schultz Liora M, Zhang Lichao, Khodadoust Michael S, Narayan Rupa, Czerwinski Debra K, Levy Ronald, Elias Joshua E", "evidence": [ { "database": "IEDB", "id": "624351", "url": "https://www.iedb.org/epitope/624351" }, { "database": "IEDB", "id": "624561", "url": "https://www.iedb.org/epitope/624561" }, { "database": "IEDB", "id": "624631", "url": "https://www.iedb.org/epitope/624631" }, { "database": "IEDB", "id": "931445", "url": "https://www.iedb.org/epitope/931445" } ], "reference": [ { "type": "PubMed", "id": "29493099", "url": "https://glygen.org/publication/PubMed/29493099" } ] }, { "title": "Comparison of the MHC I Immunopeptidome Repertoire of B-Cell Lymphoblasts Using Two Isolation Methods.", "journal": "Proteomics", "date": "2018-06", "authors": "Lanoix Jo\u00ebl, Durette Chantal, Courcelles Mathieu, Cossette \u00c9milie, Comtois-Marotte Simon, Hardy Marie-Pierre, C\u00f4t\u00e9 Caroline, Perreault Claude, Thibault Pierre", "evidence": [ { "database": "IEDB", "id": "486791", "url": "https://www.iedb.org/epitope/486791" } ], "reference": [ { "type": "PubMed", "id": "29508533", "url": "https://glygen.org/publication/PubMed/29508533" } ] }, { "title": "The natural HLA ligandome of glioblastoma stem-like cells: antigen discovery for T cell-based immunotherapy.", "journal": "Acta neuropathologica", "date": "2018-06", "authors": "Neidert Marian Christoph, Kowalewski Daniel Johannes, Silginer Manuela, Kapolou Konstantina, Backert Linus, Freudenmann Lena Katharina, Peper Janet Kerstin, Marcu Ana, Wang Sophie Shih-Y\u00fcng, Walz Juliane Sarah, Wolpert Fabian, Rammensee Hans-Georg, Henschler Reinhard, Lamszus Katrin, Westphal Manfred, Roth Patrick, Regli Luca, Stevanovi\u0107 Stefan, Weller Michael, Eisele G\u00fcnter", "evidence": [ { "database": "IEDB", "id": "224791", "url": "https://www.iedb.org/epitope/224791" }, { "database": "IEDB", "id": "476641", "url": "https://www.iedb.org/epitope/476641" }, { "database": "IEDB", "id": "486791", "url": "https://www.iedb.org/epitope/486791" }, { "database": "IEDB", "id": "778795", "url": "https://www.iedb.org/epitope/778795" }, { "database": "IEDB", "id": "1091405", "url": "https://www.iedb.org/epitope/1091405" } ], "reference": [ { "type": "PubMed", "id": "29557506", "url": "https://glygen.org/publication/PubMed/29557506" } ] }, { "title": "Immunopeptidomic Profiling of HLA-A2-Positive Triple Negative Breast Cancer Identifies Potential Immunotherapy Target Antigens.", "journal": "Proteomics", "date": "2018-06", "authors": "Ternette Nicola, Olde Nordkamp Marloes J M, M\u00fcller Julius, Anderson Amanda P, Nicastri Annalisa, Hill Adrian V S, Kessler Benedikt M, Li Demin", "evidence": [ { "database": "IEDB", "id": "778795", "url": "https://www.iedb.org/epitope/778795" } ], "reference": [ { "type": "PubMed", "id": "29786170", "url": "https://glygen.org/publication/PubMed/29786170" } ] }, { "title": "Mapping the HLA Ligandome of Colorectal Cancer Reveals an Imprint of Malignant Cell Transformation.", "journal": "Cancer research", "date": "2018-08-15", "authors": "L\u00f6ffler Markus W, Kowalewski Daniel J, Backert Linus, Bernhardt J\u00f6rg, Adam Patrick, Schuster Heiko, Dengler Florian, Backes Daniel, Kopp Hans-Georg, Beckert Stefan, Wagner Silvia, K\u00f6nigsrainer Ingmar, Kohlbacher Oliver, Kanz Lothar, K\u00f6nigsrainer Alfred, Rammensee Hans-Georg, Stevanovi\u0107 Stefan, Haen Sebastian P", "evidence": [ { "database": "IEDB", "id": "778795", "url": "https://www.iedb.org/epitope/778795" } ], "reference": [ { "type": "PubMed", "id": "29789417", "url": "https://glygen.org/publication/PubMed/29789417" } ] }, { "title": "A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands.", "journal": "Science immunology", "date": "2018-10-12", "authors": "Faridi Pouya, Li Chen, Ramarathinam Sri H, Vivian Julian P, Illing Patricia T, Mifsud Nicole A, Ayala Rochelle, Song Jiangning, Gearing Linden J, Hertzog Paul J, Ternette Nicola, Rossjohn Jamie, Croft Nathan P, Purcell Anthony W", "evidence": [ { "database": "IEDB", "id": "224791", "url": "https://www.iedb.org/epitope/224791" } ], "reference": [ { "type": "PubMed", "id": "30315122", "url": "https://glygen.org/publication/PubMed/30315122" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q96L73", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q96L73" }, { "database": "O-GlcNAc Atlas", "id": "Q96L73", "url": "https://oglcnac.org/atlas/detail/Q96L73" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome.", "journal": "Nature communications", "date": "2018-11-08", "authors": "Illing Patricia T, Pymm Phillip, Croft Nathan P, Hilton Hugo G, Jojic Vladimir, Han Alex S, Mendoza Juan L, Mifsud Nicole A, Dudek Nadine L, McCluskey James, Parham Peter, Rossjohn Jamie, Vivian Julian P, Purcell Anthony W", "evidence": [ { "database": "IEDB", "id": "624631", "url": "https://www.iedb.org/epitope/624631" } ], "reference": [ { "type": "PubMed", "id": "30410026", "url": "https://glygen.org/publication/PubMed/30410026" } ] }, { "title": "The Length Distribution and Multiple Specificity of Naturally Presented HLA-I Ligands.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2018-12-15", "authors": "Gfeller David, Guillaume Philippe, Michaux Justine, Pak Hui-Song, Daniel Roy T, Racle Julien, Coukos George, Bassani-Sternberg Michal", "evidence": [ { "database": "IEDB", "id": "224791", "url": 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Michaux Justine, Bilic Ilija, Hirsekorn Antje, Calviello Lorenzo, Sim\u00f3-Riudalbas Laia, Planet Evarist, Lubi\u0144ski Jan, Bry\u015bkiewicz Marta, Wiznerowicz Maciej, Xenarios Ioannis, Zhang Lin, Trono Didier, Harari Alexandre, Ohler Uwe, Coukos George, Bassani-Sternberg Michal", "evidence": [ { "database": "IEDB", "id": "506550", "url": "https://www.iedb.org/epitope/506550" }, { "database": "IEDB", "id": "507936", "url": "https://www.iedb.org/epitope/507936" }, { "database": "IEDB", "id": "699771", "url": "https://www.iedb.org/epitope/699771" }, { "database": "IEDB", "id": "837676", "url": "https://www.iedb.org/epitope/837676" }, { "database": "IEDB", "id": "2072427", "url": "https://www.iedb.org/epitope/2072427" } ], "reference": [ { "type": "PubMed", "id": "32157095", "url": "https://glygen.org/publication/PubMed/32157095" } ] }, { "title": "Immunopeptidomic Analysis Reveals That Deamidated HLA-bound Peptides Arise Predominantly from Deglycosylated Precursors.", "journal": "Molecular & cellular proteomics : MCP", "date": "2020-07", "authors": "Mei Shutao, Ayala Rochelle, Ramarathinam Sri H, Illing Patricia T, Faridi Pouya, Song Jiangning, Purcell Anthony W, Croft Nathan P", "evidence": [ { "database": "IEDB", "id": "224791", "url": "https://www.iedb.org/epitope/224791" }, { "database": "IEDB", "id": "431481", "url": "https://www.iedb.org/epitope/431481" }, { "database": "IEDB", "id": "506550", "url": "https://www.iedb.org/epitope/506550" }, { "database": "IEDB", "id": "1321221", "url": "https://www.iedb.org/epitope/1321221" }, { "database": "IEDB", "id": "1327889", "url": "https://www.iedb.org/epitope/1327889" } ], "reference": [ { "type": "PubMed", "id": "32357974", "url": "https://glygen.org/publication/PubMed/32357974" } ] }, { "title": "In-depth mining of the immunopeptidome of an acute myeloid leukemia cell line using complementary ligand enrichment and data acquisition strategies.", "journal": "Molecular immunology", "date": "2020-07", "authors": "Pandey Kirti, Mifsud Nicole A, Lim Kam Sian Terry C C, Ayala Rochelle, Ternette Nicola, Ramarathinam Sri H, Purcell Anthony W", "evidence": [ { "database": "IEDB", "id": "506550", "url": "https://www.iedb.org/epitope/506550" }, { "database": "IEDB", "id": "715205", "url": "https://www.iedb.org/epitope/715205" }, { "database": "IEDB", "id": "1358392", "url": "https://www.iedb.org/epitope/1358392" }, { "database": "IEDB", "id": "1363832", "url": "https://www.iedb.org/epitope/1363832" }, { "database": "IEDB", "id": "1368658", "url": "https://www.iedb.org/epitope/1368658" }, { "database": "IEDB", "id": "1375378", "url": "https://www.iedb.org/epitope/1375378" } ], "reference": [ { "type": "PubMed", "id": "32387766", "url": "https://glygen.org/publication/PubMed/32387766" } ] }, { "title": "Multiplexed relative and absolute quantitative immunopeptidomics reveals MHC I repertoire alterations induced by CDK4/6 inhibition.", "journal": "Nature communications", "date": "2020-06-02", "authors": "Stopfer Lauren E, Mesfin Joshua M, Joughin Brian A, Lauffenburger Douglas A, White Forest M", "evidence": [ { "database": "IEDB", "id": "1083668", "url": "https://www.iedb.org/epitope/1083668" } ], "reference": [ { "type": "PubMed", "id": "32488085", "url": "https://glygen.org/publication/PubMed/32488085" } ] }, { "title": "Extending the Comprehensiveness of Immunopeptidome Analyses Using Isobaric Peptide Labeling.", "journal": "Analytical chemistry", "date": "2020-07-07", "authors": "Pfammatter Sibylle, Bonneil Eric, Lanoix Joel, Vincent Krystel, Hardy Marie-Pierre, Courcelles Mathieu, Perreault Claude, Thibault Pierre", "evidence": [ { "database": "IEDB", "id": "476641", "url": "https://www.iedb.org/epitope/476641" }, { "database": "IEDB", "id": "486791", "url": "https://www.iedb.org/epitope/486791" }, { "database": "IEDB", "id": "575833", "url": "https://www.iedb.org/epitope/575833" }, { "database": "IEDB", "id": "837676", "url": "https://www.iedb.org/epitope/837676" }, { "database": "IEDB", "id": "1302220", "url": "https://www.iedb.org/epitope/1302220" } ], "reference": [ { "type": "PubMed", "id": "32502341", "url": "https://glygen.org/publication/PubMed/32502341" } ] }, { "title": "Solving an MHC allele-specific bias in the reported immunopeptidome.", "journal": "JCI insight", "date": "2020-10-02", "authors": "Klatt Martin G, Mack Kyeara N, Bai Yang, Aretz Zita E H, Nathan Levy I, Mun Sung Soo, Dao Tao, Scheinberg David A", "evidence": [ { "database": "IEDB", "id": "506550", "url": "https://www.iedb.org/epitope/506550" } ], "reference": [ { "type": "PubMed", "id": "32897882", "url": "https://glygen.org/publication/PubMed/32897882" } ] }, { "title": "Spliced Peptides and Cytokine-Driven Changes in the Immunopeptidome of Melanoma.", "journal": "Cancer immunology research", "date": "2020-10", "authors": "Faridi Pouya, Woods Katherine, Ostrouska Simone, Deceneux Cyril, Aranha Ritchlynn, Duscharla Divya, Wong Stephen Q, Chen Weisan, Ramarathinam Sri H, Lim Kam Sian Terry C C, Croft Nathan P, Li Chen, Ayala Rochelle, Cebon Jonathan S, Purcell Anthony W, Schittenhelm Ralf B, Behren Andreas", "evidence": [ { "database": "IEDB", "id": "506550", "url": "https://www.iedb.org/epitope/506550" }, { "database": "IEDB", "id": "837676", "url": "https://www.iedb.org/epitope/837676" }, { "database": "IEDB", "id": "1368658", "url": "https://www.iedb.org/epitope/1368658" }, { "database": "IEDB", "id": "1975507", "url": "https://www.iedb.org/epitope/1975507" }, { "database": "IEDB", "id": "1982402", "url": "https://www.iedb.org/epitope/1982402" } ], "reference": [ { "type": "PubMed", "id": "32938616", "url": "https://glygen.org/publication/PubMed/32938616" } ] }, { "title": "Biogenesis of HLA Ligand Presentation in Immune Cells Upon Activation Reveals Changes in Peptide Length Preference.", "journal": "Frontiers in immunology", "date": "2020", "authors": "Marino Fabio, Semilietof Aikaterini, Michaux Justine, Pak Hui-Song, Coukos George, M\u00fcller Markus, Bassani-Sternberg Michal", "evidence": [ { "database": "IEDB", "id": "476641", "url": "https://www.iedb.org/epitope/476641" }, { "database": "IEDB", "id": "486791", "url": "https://www.iedb.org/epitope/486791" }, { "database": "IEDB", "id": "506550", "url": "https://www.iedb.org/epitope/506550" }, { "database": "IEDB", "id": "837676", "url": "https://www.iedb.org/epitope/837676" } ], "reference": [ { "type": "PubMed", "id": "32983136", "url": "https://glygen.org/publication/PubMed/32983136" } ] }, { "title": "Thermostability profiling of MHC-bound peptides: a new dimension in immunopeptidomics and aid for immunotherapy design.", "journal": "Nature communications", "date": "2020-12-09", "authors": "Jappe Emma C, Garde Christian, Ramarathinam Sri H, Passantino Ethan, Illing Patricia T, Mifsud Nicole A, Trolle Thomas, Kringelum Jens V, Croft Nathan P, Purcell Anthony W", "evidence": [ { "database": "IEDB", "id": "224791", "url": "https://www.iedb.org/epitope/224791" }, { "database": "IEDB", "id": "506550", "url": "https://www.iedb.org/epitope/506550" }, { "database": "IEDB", "id": "507936", "url": "https://www.iedb.org/epitope/507936" }, { "database": "IEDB", "id": "577870", "url": "https://www.iedb.org/epitope/577870" }, { "database": "IEDB", "id": "581846", "url": "https://www.iedb.org/epitope/581846" }, { "database": "IEDB", "id": "1302220", "url": "https://www.iedb.org/epitope/1302220" }, { "database": "IEDB", "id": "1368623", "url": "https://www.iedb.org/epitope/1368623" }, { "database": "IEDB", "id": "1369162", "url": "https://www.iedb.org/epitope/1369162" }, { "database": "IEDB", "id": "1370638", "url": "https://www.iedb.org/epitope/1370638" } ], "reference": [ { "type": "PubMed", "id": "33298915", "url": "https://glygen.org/publication/PubMed/33298915" } ] }, { "title": "The Impact of Biomaterial Cell Contact on the Immunopeptidome.", "journal": "Frontiers in bioengineering and biotechnology", "date": "2020", "authors": "Ghosh Michael, Hartmann Hanna, Jakobi Meike, M\u00e4rz L\u00e9o, Bichmann Leon, Freudenmann Lena K, M\u00fchlenbruch Lena, Segan S\u00f6ren, Rammensee Hans-Georg, Schneiderhan-Marra Nicole, Shipp Christopher, Stevanovi\u0107 Stefan, Joos Thomas O", "evidence": [ { "database": "IEDB", "id": "506550", "url": "https://www.iedb.org/epitope/506550" } ], "reference": [ { "type": "PubMed", "id": "33392160", "url": "https://glygen.org/publication/PubMed/33392160" } ] }, { "title": "CIITA-Transduced Glioblastoma Cells Uncover a Rich Repertoire of Clinically Relevant Tumor-Associated HLA-II Antigens.", "journal": "Molecular & cellular proteomics : MCP", "date": "2021", "authors": "Forlani Greta, Michaux Justine, Pak HuiSong, Huber Florian, Marie Joseph Elodie Lauret, Ramia Elise, Stevenson Brian J, Linnebacher Michael, Accolla Roberto S, Bassani-Sternberg Michal", "evidence": [ { "database": "IEDB", "id": "224791", "url": "https://www.iedb.org/epitope/224791" }, { "database": "IEDB", "id": "486791", "url": "https://www.iedb.org/epitope/486791" }, { "database": "IEDB", "id": "506550", "url": "https://www.iedb.org/epitope/506550" }, { "database": "IEDB", "id": "715848", "url": "https://www.iedb.org/epitope/715848" }, { "database": "IEDB", "id": "837676", "url": "https://www.iedb.org/epitope/837676" } ], "reference": [ { "type": "PubMed", "id": "33592498", "url": "https://glygen.org/publication/PubMed/33592498" } ] }, { "title": "Alterations in the HLA-B*57:01 Immunopeptidome by Flucloxacillin and Immunogenicity of Drug-Haptenated Peptides.", "journal": "Frontiers in immunology", "date": "2020", "authors": "Puig Montserrat, Ananthula Suryatheja, Venna Ramesh, Kumar Polumuri Swamy, Mattson Elliot, Walker Lacey M, Cardone Marco, Takahashi Mayumi, Su Shan, Boyd Lisa F, Natarajan Kannan, Abdoulaeva Galina, Wu Wells W, Roderiquez Gregory, Hildebrand William H, Beaucage Serge L, Li Zhihua, Margulies David H, Norcross Michael A", "evidence": [ { "database": "IEDB", "id": "624631", "url": "https://www.iedb.org/epitope/624631" } ], "reference": [ { "type": "PubMed", "id": "33633747", "url": "https://glygen.org/publication/PubMed/33633747" } ] }, { "title": "Most non-canonical proteins uniquely populate the proteome or immunopeptidome.", "journal": "Cell reports", "date": "2021-03-09", "authors": "Ruiz Cuevas Maria Virginia, Hardy Marie-Pierre, Holl\u00fd Jaroslav, Bonneil \u00c9ric, Durette Chantal, Courcelles Mathieu, Lanoix Jo\u00ebl, C\u00f4t\u00e9 Caroline, Staudt Louis M, Lemieux S\u00e9bastien, Thibault Pierre, Perreault Claude, Yewdell Jonathan W", "evidence": [ { "database": "IEDB", "id": "431481", "url": "https://www.iedb.org/epitope/431481" }, { "database": "IEDB", "id": "575833", "url": "https://www.iedb.org/epitope/575833" } ], "reference": [ { "type": "PubMed", "id": "33691108", "url": "https://glygen.org/publication/PubMed/33691108" } ] }, { "title": "Carbamazepine Induces Focused T Cell Responses in Resolved Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Cases But Does Not Perturb the Immunopeptidome for T Cell Recognition.", "journal": "Frontiers in immunology", "date": "2021", "authors": "Mifsud Nicole A, Illing Patricia T, Lai Jeffrey W, Fettke Heidi, Hensen Luca, Huang Ziyi, Rossjohn Jamie, Vivian Julian P, Kwan Patrick, Purcell Anthony W", "evidence": [ { "database": "IEDB", "id": "931445", "url": "https://www.iedb.org/epitope/931445" }, { "database": "IEDB", "id": "1370638", "url": "https://www.iedb.org/epitope/1370638" } ], "reference": [ { "type": "PubMed", "id": "33912179", "url": "https://glygen.org/publication/PubMed/33912179" } ] }, { "title": "IFN\u03b3 Modulates the Immunopeptidome of Triple Negative Breast Cancer Cells by Enhancing and Diversifying Antigen Processing and Presentation.", "journal": "Frontiers in immunology", "date": "2021", "authors": "Goncalves Gabriel, Mullan Kerry A, Duscharla Divya, Ayala Rochelle, Croft Nathan P, Faridi Pouya, Purcell Anthony W", "evidence": [ { "database": "IEDB", "id": "506550", "url": "https://www.iedb.org/epitope/506550" }, { "database": "IEDB", "id": "837676", "url": "https://www.iedb.org/epitope/837676" }, { "database": "IEDB", "id": "950863", "url": "https://www.iedb.org/epitope/950863" }, { "database": "IEDB", "id": "1877174", "url": "https://www.iedb.org/epitope/1877174" }, { "database": "IEDB", "id": "1892346", "url": "https://www.iedb.org/epitope/1892346" }, { "database": "IEDB", "id": "1897697", "url": "https://www.iedb.org/epitope/1897697" }, { "database": "IEDB", "id": "1912115", "url": "https://www.iedb.org/epitope/1912115" }, { "database": "IEDB", "id": "1912177", "url": "https://www.iedb.org/epitope/1912177" }, { "database": "IEDB", "id": "1925369", "url": "https://www.iedb.org/epitope/1925369" }, { "database": "IEDB", "id": "1939261", "url": "https://www.iedb.org/epitope/1939261" } ], "reference": [ { "type": "PubMed", "id": "33968037", "url": "https://glygen.org/publication/PubMed/33968037" } ] }, { "title": "NMD inhibition by 5-azacytidine augments presentation of immunogenic frameshift-derived neoepitopes.", "journal": "iScience", "date": "2021-04-23", "authors": "Becker Jonas P, Helm Dominic, Rettel Mandy, Stein Frank, Hernandez-Sanchez Alejandro, Urban Katharina, Gebert Johannes, Kloor Matthias, Neu-Yilik Gabriele, von Knebel Doeberitz Magnus, Hentze Matthias W, Kulozik Andreas E", "evidence": [ { "database": "IEDB", "id": "506550", "url": "https://www.iedb.org/epitope/506550" }, { "database": "IEDB", "id": "1321221", "url": "https://www.iedb.org/epitope/1321221" }, { "database": "IEDB", "id": "1711993", "url": "https://www.iedb.org/epitope/1711993" } ], "reference": [ { "type": "PubMed", "id": "33981976", "url": "https://glygen.org/publication/PubMed/33981976" } ] }, { "title": "The Effect of Interferons on Presentation of Defective Ribosomal Products as HLA Peptides.", "journal": "Molecular & cellular proteomics : MCP", "date": "2021", "authors": "Komov Liran, Melamed Kadosh Dganit, Barnea Eilon, Admon Arie", "evidence": [ { "database": "IEDB", "id": "506550", "url": "https://www.iedb.org/epitope/506550" }, { "database": "IEDB", "id": "575833", "url": "https://www.iedb.org/epitope/575833" }, { "database": "IEDB", "id": "1553762", "url": "https://www.iedb.org/epitope/1553762" } ], "reference": [ { "type": "PubMed", "id": "34087483", "url": "https://glygen.org/publication/PubMed/34087483" } ] }, { "title": "Immunopeptidogenomics: Harnessing RNA-Seq to Illuminate the Dark Immunopeptidome.", "journal": "Molecular & cellular proteomics : MCP", "date": "2021", "authors": "Scull Katherine E, Pandey Kirti, Ramarathinam Sri H, Purcell Anthony W", "evidence": [ { "database": "IEDB", "id": "506550", "url": "https://www.iedb.org/epitope/506550" }, { "database": "IEDB", "id": "1368658", "url": "https://www.iedb.org/epitope/1368658" }, { "database": "IEDB", "id": "1375378", "url": "https://www.iedb.org/epitope/1375378" } ], "reference": [ { "type": "PubMed", "id": "34509645", "url": "https://glygen.org/publication/PubMed/34509645" } ] }, { "title": "Characterization of HLA-A*33:03 epitopes via immunoprecipitation and LC-MS/MS.", "journal": "Proteomics", "date": "2022", "authors": "Khan A, Shin JY, So MK, Na JH, Justesen S, Ansari AA, Ko BJ, Ahn SM", "evidence": [ { "database": "IEDB", "id": "1714718", "url": "https://www.iedb.org/epitope/1714718" } ], "reference": [ { "type": "PubMed", "id": "34561969", "url": "https://glygen.org/publication/PubMed/34561969" } ] }, { "title": "HLA Allele-Specific Quantitative Profiling of Type 1 Diabetic B Lymphocyte Immunopeptidome.", "journal": "Journal of proteome research", "date": "2022-01-07", "authors": "Sudhir Putty-Reddy, Lin Tai-Du, Zhang Qibin", "evidence": [ { "database": "IEDB", "id": "224791", "url": "https://www.iedb.org/epitope/224791" } ], "reference": [ { "type": "PubMed", "id": "34932366", "url": "https://glygen.org/publication/PubMed/34932366" } ] }, { "title": "Immunopeptidomic analysis of influenza A virus infected human tissues identifies internal proteins as a rich source of HLA ligands.", "journal": "PLoS pathogens", "date": "2022-01", "authors": "Nicholas Ben, Bailey Alistair, Staples Karl J, Wilkinson Tom, Elliott Tim, Skipp Paul", "evidence": [ { "database": "IEDB", "id": "2007161", "url": "https://www.iedb.org/epitope/2007161" }, { "database": "IEDB", "id": "2012022", "url": "https://www.iedb.org/epitope/2012022" }, { "database": "IEDB", "id": "2025175", "url": "https://www.iedb.org/epitope/2025175" }, { "database": "IEDB", "id": "2030718", "url": "https://www.iedb.org/epitope/2030718" }, { "database": "IEDB", "id": "2031549", "url": "https://www.iedb.org/epitope/2031549" }, { "database": "IEDB", "id": "2047841", "url": "https://www.iedb.org/epitope/2047841" }, { "database": "IEDB", "id": "2048481", "url": "https://www.iedb.org/epitope/2048481" } ], "reference": [ { "type": "PubMed", "id": "35051231", "url": "https://glygen.org/publication/PubMed/35051231" } ] }, { "title": "Tumour-associated antigenic peptides are present in the HLA class I ligandome of cancer cell line derived extracellular vesicles.", "journal": "Immunology", "date": "2022-06", "authors": "Kumar Pankaj, Boyne Caitlin, Brown Sydney, Qureshi Ayesha, Thorpe Peter, Synowsky Silvia A, Shirran Sally, Powis Simon J", "evidence": [ { "database": "IEDB", "id": "778795", "url": "https://www.iedb.org/epitope/778795" } ], "reference": [ { "type": "PubMed", "id": "35318648", "url": "https://glygen.org/publication/PubMed/35318648" } ] }, { "title": "Soluble HLA peptidome of pleural effusions is a valuable source for tumor antigens.", "journal": "Journal for immunotherapy of cancer", "date": "2022-05", "authors": "Khazan-Kost Sofia, Cafri Gal, Melamed Kadosh Dganit, Mooshayef Navit, Chatterji Sumit, Dominissini Dan, Manor Sigal, Zisser Bracha, Broday Limor, Talalai Efrosiniia, Shemer Anat, Zadok Oranit, Ofek Efrat, Onn Amir, Admon Arie, Peled Michael", "evidence": [ { "database": "IEDB", "id": "224791", "url": "https://www.iedb.org/epitope/224791" }, { "database": "IEDB", "id": "476641", "url": "https://www.iedb.org/epitope/476641" }, { "database": "IEDB", "id": "486791", "url": "https://www.iedb.org/epitope/486791" }, { "database": "IEDB", "id": "506550", "url": "https://www.iedb.org/epitope/506550" }, { "database": "IEDB", "id": "2259930", "url": "https://www.iedb.org/epitope/2259930" } ], "reference": [ { "type": "PubMed", "id": "35580925", "url": "https://glygen.org/publication/PubMed/35580925" } ] }, { "title": "Multi-Omic Analysis of Two Common P53 Mutations: Proteins Regulated by Mutated P53 as Potential Targets for Immunotherapy.", "journal": "Cancers", "date": "2022-08-17", "authors": "Vadakekolathu Jayakumar, Boocock David J, Pandey Kirti, Guinn Barbara-Ann, Legrand Antoine, Miles Amanda K, Coveney Clare, Ayala Rochelle, Purcell Anthony W, McArdle Stephanie E", "evidence": [ { "database": "IEDB", "id": "575833", "url": "https://www.iedb.org/epitope/575833" } ], 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"PubMed", "id": "39336709", "url": "https://glygen.org/publication/PubMed/39336709" } ] } ], "pathway": [ { "id": "hsa:64324", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:64324", "resource": "KEGG Pathway" }, { "id": "R-HSA-3214841", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3214841", "resource": "Reactome", "description": "PKMTs methylate histone lysines" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K001-1", "protein_name": "Histone-lysine N-methyltransferase NSD3", "gene_name": "Nsd3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIVEDGGPTPFEATLQQGFQCPPATEDLPPLTNGYPPSISLYETQTKYPPYSQYPNGSANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPPPLLPPPPPPVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEVQASEHLKSKHESRKEKRKKSSRHESSRSEERKSHKVPKLEPEGQNRPNERVDPAPEKPREEPVLKEAVPVQPILSSVPTTETSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHEQYEELLAEAAKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALQMTREERVEQYTFIYIDKQPEESPSQAKKSVTSKAEVKKPRRPRSVGNSQPEQTSAGEVASPQSSTDPRRQSQRRHTSVEEDGPPPVKIAWRTAAARKSLPASITMHKGSLDLHKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISSPSQRNEKSTPSASPPEATSGSAGPVEKKQQRRSIRTRSESEKSTEVVSKKKIKKEQQVETSPQASLKTGLQKGASEISDSCKPLKKRSRASTDVETASCTYRDTSDSDSRGPSDGQVGFGKQVDSPSAAADADASDAQSVDSSLSRRGVGLSKKDTVCQVCENTGDSLVACEGECCRHFHPECLGLAAVPEGRFTCEECETGQHPCFSCKVSGKDVKRCSVSVCGKFYHEACVRKFPTAIFESKGFRCPQHCCSSCSMEKDIHKASKGRMMKCLRCPIAYHFGDACVAAGSVSVSSHILICSNHSKRSSHSAAINVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLSESNRAELMKLPMIPSSSASKKRCEKGGRLLCCESCPASFHPECLSIDMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAETCSPRSVPLNIQGLKHGVGDFPVLFFGSHDYYWVHQGRVFPYVEGDTNFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKTSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPGDENPCGLESECLNRMSQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTVCHCGADNCSGFLGVRPKSACTSAADEKTKNAKLKKRRRGKAEAKQIHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECGSAAISFCEFCPHSFCKAHEKGALVPSALEGRLCCSNHDPASPVSPEYWSKMRCKWESQDGGEEVKE", "length": 1444 }, "evidence": [ { "id": "FB:FBgn0039559", "url": "https://alliancegenome.org/gene/FB:FBgn0039559#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A287AA00-1", "protein_name": "Histone-lysine N-methyltransferase, H3 lysine-36 specific", "gene_name": "NSD1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDQTCELSRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTASGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGSADGSESFQDPEKSDSRAQSPVVCTSLSPGGPTALAMKQEPSCNNSPELQVKVTKTVKNGFLHFENFTCVDDADIDSEMDPEQPVTEDESIEEIFEETQTNATCNYEPKSENGVDVAMGNEQDSTPESRHGAVKPPFLALAPQTETQKNKQRNEVDGSNEKASLLPAPFSLGDAKVTIEEQLNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKATPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKESKNRKCITSSIKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADEKEKPCVKSRARKSSDNPKRTSVKKGHMQFEAHKEERRGKIPENLGLNFISGDVSDKQASNELSRIANSLTGSSTAPGSFLFSSCAKNTAKKEFETSNCDSLLGLSEGALISKRSGEKKKLQQSLVCSSKVQLCYIGAGDEEKRSDSISICTTSDDGSSDLDPIDHSSESDNSVLEITDTFDRTENMLPVQKNEKVKYSRYPATNTKVKAKQKTLITNSHTDHLTDCTKIAEPGTETSQVNIADLKVSTLVRKPQSDFRNDGLSPKFNTPSSISGDNSLIKGGATNQALLHSKSKQPKIRSIKCKHKENPVVGEPPVANEDCSLKCCSSDTKGSPLASISKSGKMDGLKLLSNMHEKTRDSNDIETAVVKHVLSELKELSYRSLSEDVSDSGTSKPSKPLLFSSASGQNHMPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGLGDCSTSSPVGASKVLVSGGSTYNSEKNGDSTQDPVRPSPTGGDSTLSGELSGSPPGLVSGKRDLPASGKSRSNCVTRRNCGRSKPSKLRDGFSAQVGRNTVNRKALKTERKRKLNRLPAVTLEAALQRERESRGSENGSSRGEAESPGKEEPLPLKGHLTSEDGAHFSSVSFDNKVNHSDPGKIPEKGPSFENVKGPELDSEMNSENDELNCVNQAVPKKRWQRLNQRRIKPRKRTNRFREKENSEGAFGVLLPADPVKKGDALPDQRPPPPPANILEDALTDPSHADCLDSAEPRLNVCDKSSASIEEMEKEPGIPSLTPQPELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLLARCRSSAQNKQVEENSLISTKEEPPVLEREAPFLEGPLAQSEVGGGHAELPQLTLSVPVALEVSPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLPKKCYEAGHLENDITESCATSRSKEFAGGATKLFDKPRKRKRQRHATVKMHCKKVKNDSSSKEPPSSEGELMAHRTAASPKETIEEGVENDHGMPASKKLQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFTKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRTQGEVTKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIREYVPPPVPLPPGPSTHLAEPSSGVAAQGPKMSDKPSADTNQTLSLSKKALAGTCQRPPLPERPPDRTDSRPQPVDRVRDLAGSGTKSQSLVSSQKPLDRPPALAGPRSQLSDKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTPVPTGLRLPPPDRLLVTSGPKPQSSDRPPDKSHASLSQRLPPPDKVLSAVVQTLVAKEKALRPVDQNTQSKNRAALVMDLIDLTPRQKERAASPHDIIPQADEKMPVLESTSWPASKCLGQMPRAVERSSVSDPVLLPPSKAAAPPEHPWQAVKSLTQARLLSQPPAKAFLYEPTTQASGRAPAGAEQTTGPPSQAPGLVKQVKQLVGGQQLPGLAAKSGQSFRPLGKTPSSLSTEEKKLTTTEQNPWALGKASPGPGLWPMVAGQTLAQSCWSSGSTQTLAQTCWSLGRGQDPKPEQNTLPALNQAPSSHKCAESEQK", "length": 2701 }, "evidence": [ { "id": "Q96L73", "url": "https://omabrowser.org/oma/group/Q96L73/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I6AMN8-1", "protein_name": "Histone-lysine N-methyltransferase, H3 lysine-36 specific", "gene_name": "Nsd1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDQSCELSRRNCLLSFSNSVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLPTASGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLSGSADGSESFQDPAKSDSRAQSPIVCTSLSPGGPTALAMNQEPTCNNPPELQLSVTKTTKNGFLHFDNFTCVDDADVDSEMDPEQPVTEDESIEEIFEETQTNASCNYEPKSENGVEMAMGSEQDSMPESRHGAVEQPFVPLAPQTEKQKNKQRSEVDGSNEKTALLPAPNSLGDTNVTIEEQFNSINLSFQDDPDSSTSTLGNMLELPGTSSPSTSQELPFCHPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVANRRPYREYYVEAFGDPSEKAWVAGKAIVMFEGRHQFEELPVLRKRGKQKEKGYRHKVPQKILSKWEASVGLAEQCDVPRGPKTQKCVPSSAKLDSEEDMPFEDCANDPDSEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRVRKSSDNIKRTSVKKGLMPFEAQKEERRGKSPENLGLDFLSGGVSDKQASNELSRIANSLTGSSAAPGQFLFSSCGQNTAKTDFETPNCDSLSGLSESALISKHSGEKKKLQPGQVCSSKVQLCYVGAGDEEKRSDSVSVCTTSDDGSSDLDPTEHNSEFHKSVLEVTDALDKTENALSMHKNETKYSRYPATNRVKEKQKSLITNSHTDHLMDSTKTVEPGTAEISQVNLSDLKISSPIPKPQPEFRNDGLTTKFNAPPGIRNENSLTKGGLANQTLLPLKCRQPKFRSIKCKHKESPTAAETSATSEDLSLKCCSSDTNGSPMTSISKSGKGEGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLSEDVSDSGTSKSSKPLLFSSASSQNHIPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNVASYRTPDRGDCSSGSPVGTSKVLVLGGSTHNSEKPGDSTQDSVRLSPGGGDSALSGELSSSLSVLPSDKRDLPACGKIRSNCIPRRNCGRAKLSPKLRVTISTQMAKPSVNPKALKTERKRKLSRLPAVTLAANGLGNKESGGSVNGPLKGGAQDPAKEEPLQQMDLLRNEETHFDSKVKQSDPDKILEKEPSFENRKGPEVGSEINIENDEPHGVDQVVPKKRWQRLNQRRPKPGKRASRFREKENSEGAFGVLLPGDPVQKGRDDYLEQRAPPTSILEDSAADPNHVSHSESVGPRLNVCDKSSVSMGDLEKETGIPSLTPQTKIPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEDESLLARCRSSAQNKQVDENSLISTKEEPPVLEREAPFLEGPLVQSDLGVAHAELPQLTLSVPVAPEVSPRPTLESEELLVKTPGNYEGKRQRKPTKKLLESNDLDPGFMPKKGDLGLSRKCCESGHLENGVGDSRATPHLKEFGGGTTRIFDKPRKRKRQRHGTARVHYKRVKKEDSARETPSSAEGELMIHRTAASPKEILEEGIEHDPGMSASKRLQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVVQNKGFRCPLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPDVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIVTEEKSRKFKRKPHGKRRSQGEVTKEREDECFSCGDGGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDVCGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIREYVPPTATLSPSPGTQQTEQSSEMGTQGPKKSDQPPTDATQMLSLSKKAVTGTCQRPLLPERPPERTDSSSHLLDRIRDLAGSGTKSQSLVSSQRPQDRPPAKEGPRPQPPDRASPVTRPSSSPSVSSLPLERPLRMTEPRLDKSIGAASPKSQAVEKPPAPTGLRLSSPDRLLNTNSPKPQISDRPPDKSHASLTQRLPPPEKVLSAVVQSLVAKEKALRPVDQNTQAKHRAAVVMDLIDLTPRQKERAASPQEVTAQADEKTPVLESSSRPTSRGLGHVPRAVEKGGVSDPLQPPGKSAAPSEHPWQAVKSLTHARFLSPPSAKAFLYESAIQASGRAPVGSEQTPGPPSPAPGLLKQVKQLSRGLTAKSGQSFRSLGKISASLPNEEKKLTTTEQSPWGLGKASPGAGLWPIVAGQTLAQACWSSGGTQTLAQNCWSLGRGQDPKPEQNAIQALNQAPSSRKCAESEQK", "length": 2689 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-080519-2", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-080519-2#orthology", "database": "AGR" }, { "id": "HGNC:14234", "url": "https://alliancegenome.org/gene/HGNC:14234#orthology", "database": "AGR" }, { "id": "MGI:1276545", "url": "https://alliancegenome.org/gene/MGI:1276545#orthology", "database": "AGR" }, { "id": "RGD:1307748", "url": "https://alliancegenome.org/gene/RGD:1307748#orthology", "database": "AGR" }, { "id": "FB:FBgn0039559", "url": "https://alliancegenome.org/gene/FB:FBgn0039559#orthology", "database": "AGR" }, { "id": "Q96L73", "url": "https://omabrowser.org/oma/group/Q96L73/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8M2B1N3-1", "protein_name": "Histone-lysine N-methyltransferase NSD3", "gene_name": "nsd3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDVYEAISDPGDDGGQQNFDSPLESGFSYPAEDVPVITNGYPTGVGTYEQQAKFALYSQFPNGSANGYGAIRNYGDHSLLLGEGTVLRPPVVQEKPQTHISPPSHSHHHQQPHHPHHHHHQQQQQHHPHNPPLLPHHHHHHPPPASHLMPQVLPPPPPLLLPSSPPLLSPQESTISNPIGQPVNTIITTTPKKTSSPEIKLKIIKTYQNGRELFESSLCGDLLQEFQAGEDSRRQHEQKKEKRKKRGSRHGAGQEESQQPSKVEEERSVVVHNPVQTTESQVAFREEQQPQSSLKSPKAELKEQKVEKHCPSVITSTGTSQEYEIGDLVWAKVGTYPWWPCMVSSDPQSNVHTRINTRGCKEYHVQFFGSVPERAWIHEKRTVVYKSENQFDELQAETLRKSTNPTEKQKLLKPQSQKERAQWEVGVGHAEAALQMTREERNENYTFIYIDKEPGADAETAAAPAPAPDSAPTAPTDTVTSPKATAKNRPERKQRRSRGSAGAKEEPIPRRQQPRRQCSMNSVGETSSPNQGEDAMEQEQPCSPPKPAPRPKEPSPPPVRTPWRTAAARKLLPLSITMKKLNVEIIKCDWQLPKQKVELPKKTESEERPSSRVKSPEGSSNKAEAETCSSEEERAASPSGWSDQEHTSAEQSTERKQQRRSVRSRSESEKSVEPVPKKKVKKEQAETAPQMDFKTGSQKGASEISDSCKPLKKRSRASTDVEMASSLYRDTSDSDSRGLNDPQTGFGKRSDSPATVDADGSDAQSVDSSLSRQGGSSSKKDTVCHVCETFGDSLVSCEGDCNRLFHPECMGSNSGKESETVCQECKTGSHPCFSCKVTEGDMKRCSVNGCGRYYHETCVRKYTGSASDTKGLRCPQHSCATCCLDRDLQKAGKGRMMRCIRCPVAYHTGDGCVAAGSVLITPHIIICSNHSSSRKNGHFSSPVNVGWCFICARGLLVHDHTDTILSSYTFKSHYLLTESNRAELMKLPMIPSSSSATKKNIGKGGRLLCCEACPASFHPECLKIEMPEGTWLCGECKSGKKPHYKQIVWVKLGNYRWWPAEICNPRLVPSNIQSLKHDIGDFPVFFFGSHDYYWINQGRVFPYVESDKNFAEGQVGINKTFKKALEEAAKRFQELKAQRETKEALEQERNSRRPPPYKLIKSNKPFGKVQLHVADLSEIPRCNCKPTDERPCSQDSQCLNRMLQYECHPQVCPAGDRCHNQCFSKRLYPDTEVIKTTGRGWGLKTKQDLKKGDFVMEYVGELIDSEECKQRIRTANENHVTNFYMLTLTKDRVIDAGPKGNLSRFMNHSCSPNCETQKWTVNGDVRIGLFTLCDISADTELTFNYNLDCLGNGRTSCHCGSENCSGFLGVKPKSAVVMEREEKVRNAKLKPKKRKLKTESKQTHELYCYCCGEGGELVMCDKKDCPKAYHLLCLNLSKPPYGRWECPWHQCSVCQRTATSFCHFCPASFCREHERGQLAVSALDKQPCCSNHDPKRPLGPQANRSQVTVKKEPLDGNANEEEEEEEEETGDGE", "length": 1563 }, "evidence": [ { "id": "FB:FBgn0039559", "url": "https://alliancegenome.org/gene/FB:FBgn0039559#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8M9PJB1-1", "protein_name": "Histone-lysine N-methyltransferase, H3 lysine-36 specific", "gene_name": "nsd1b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDAGLSDICTSPPSPDFSLDSSSPFANGLHFESILFEDEEEDEVMDPEPVSQPERNLCGSTSDCTTNTNLKTNLDGKSRRKNSKAHSSLEQDVVFQDKAKSDSGLSTLVSRPGGVLMKQKKKSKTKALPPVKYLEGEVIWAKFNRRPWWPCQVIIHPLEGVYHKMKEPPDRTTRQYFLKTFGEPEEQAWVPERSTHIFVGGYQFNNLPFVKGSGHQRDENTRHSIPKRFLNSWSASVVAAEALLLEKPRVTSPSSAFKTISEETINNTEIKVSVPVDLPNSSFLINGAVIQNNHLNSLPHNRKSKNKKKPTISHCRISEELNCEKGMIMDALDSPYSDIDSVPQIRRFPKSNEQISNHYVINYKQSSATPTVLPSTNDKDVKKNVENQGGLWFSKTGKGQVNGISRAGIKSVNCSFGKVSCKIKMPDSASMKPKDNHNTGLEHLSTEAKKALDRRVKCLPASSRLMTRALKAMEDAEWTKESSSDLETKNCVSSFDSPSLETSDVHNSILLQKMPTAAIHDLKEDSKISTHAKLSSELLCCKDDEHSVKSEDESSLVSQAPCAFHSSTRKQNSHVNDLSSSPTPSLHLNLKDMDNMNEISFKSLANEHSGQPLSFHPDSNYKFSTFLMMLKDMHDSREKDGNVLVVEPLPTTELINEEPLLISDVKDEKATSKQKKVKPKTNVMSENHLASTISKTAQRSSKKISLKKKTTDIKANIDYKSFDKLISAHRLTSKEAETNFSANVPKKRWQKFDQVSEKTVHIVEGNCIHKTERVSSENCDVSMDGTNKSCFFGPETTSNALECNQGNCQNTEAPTECKRIRKPSKRLIEWTEEYDQLFSAKKKAKKKPDSVTKIENQKCSEPVAKTYDEVKQKPQVTEQDVSRRLPELQTPPPEDQSQSTPLINTLPCQESQVLSAETLTPPPEIIPSPCDNISNRDQLQRQNPVAVGDSVCLNSKRQRKPTKKILESSIEAEPILIPKRKMKSMKICSSGHSTNSGVEQQSSKSKNKLSIESSDPPSDPMLKSTEMEIDVSPAVLQTINTESADDGSDTLRCSGSQMTESSEFYSEREENSQSDKVLLDSRRLSEEKGGSTSVKENVCPMCEKQGDLLLCEGQCCGAFHPQCTGLNEPPTGKFLCQECTSGVHSCFACKRLGEDVRRCMVPGCGKFYHGECAASHAPTVPLNRAFRCPLHACLSCFILNPANPSVAKGQLTRCIRCPVAYHSSDFCIPAGSVTLTDSNIVCPNHFTPRKGCRNHEHVNVSWCFVCSEGGSLLCCESCPAAFHRECLNIDMPEGSWYCNDCRAGKKPHYKEVVWVKVGRYRWWPAEVSNPKDIPENILRMKHDVGEFPVLFFGSNDYLWTYQARVFPYMEGDANSKEKMGKGVDSTYKKALDEAALRFKELQAEKELRQLQEDRRNDKKPPPYKQIKVNKPFGKVLIISADLSEIPRCNCKATDENPCGMDSECINRMLLYECHPQVCPAGERCQNQCFIKRQYCQVETFRTLSRGWGLRCVHDIKKGGFISEYVGEVIDEEECRARIKHAQENNIGNFYMLTLDKDRIIDAGPKGNEARFMNHCCQPNCETQKWTVNGDTRVGLFSLTDIPAGTELTFNYNLECLGNGKTVCKCGASNCSGFLGVRPKNNPPSDDKGRKLKKKRKSQQEVIKEREDECFSCGDGGQIVSCKRPGCPKVYHADCLNLTKRPAGRWECPWHQCDLCGQEAASFCEMCPSSYCVEHRDGMLFISKLDGRLSCSEHDPCGPEPLEPGEIREYPGELRPTYPINIIKSAKNKSHILNTPKAVPQAPSPLDVAPQVSPSPSCSPPPLTIFLNGPYSPNSSYEEKKEEEESVTLLEKDGEKSVPRDKSERLRIKKKTEV", "length": 1873 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-080519-2", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-080519-2#orthology", "database": "AGR" }, { "id": "HGNC:14234", "url": "https://alliancegenome.org/gene/HGNC:14234#orthology", "database": "AGR" }, { "id": "MGI:1276545", "url": "https://alliancegenome.org/gene/MGI:1276545#orthology", "database": "AGR" }, { "id": "RGD:1307748", "url": "https://alliancegenome.org/gene/RGD:1307748#orthology", "database": "AGR" }, { "id": "FB:FBgn0039559", "url": "https://alliancegenome.org/gene/FB:FBgn0039559#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0Y2K5-1", "protein_name": "Histone-lysine N-methyltransferase, H3 lysine-36 specific", "gene_name": "NSD1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEQACEVSRRSCLVPFGTSLPAAEPKGGPFGEPRGPEPPAMQLAAAKPGFGQDPSSCYIPLRRLQDLASMISAEYLGGPADGAEALPDPGSPPPRAPAPQEPPGGAGPEPAALGFPLLLRDGGDDEEEEEEEEEEDDDDDEEDDDDDDDEEPEHSRGAGSPEPPRLQPAELPGSDGGPGEDAEPSGSAAAALQLIRAKKKPTPVKYEVGDLVWAKFNRRPWWPCTICHDAVLDCHSKMKVSNRRPYREYYVDPLGEPSEKAWVAGKAIVLFEGRHQFEELPVLRRRGKQKEKGYKHKVPQRFMAKWEVSVGQAEDMLLGGPEDQKCSQNSSELDSEKEVQSEYYSNGPGAKKDRQLNGCFKSLAFDSKHSANEKGKSHIKPHMKKSSESRKRTRVKKSGMREEASKGEIQEETPESIVNNMIVGDLPEKHASHELRRIAKSITASNSTRENHLLSSFGERRFENITLKSDYGSHKSDALKNTLQGDLFSNASLEREKSSLGILCSSKLQIHYSASEAGVEKKQTESDSSSSLSDGGNSDVDTMDQSSERASSTLEVSDSSDKMEKEFPMTSSGNIKLSMYFSQKSSRRARKKSYRDRKPLGGLVTSRLDAEFAHRELEGGSSDAEMSLTALECSSDVRNDNLSLANKHATPQSVSKDSSWSAVANQTTLKLKNMKLPRIRSIKCKHKEKVAGLEPSLAEEESGMNHCSSDTKGFSGLQRDSLQRSGKADGQKLLNNVHEKPRDSAEIETAVVKHVLSELKELSYRSMNDDVGDSGTPKATVPLLFSSASGHGRLPIEPNYRFSTLLMMLKDIHDSKAKEQQLMTGQNIVPYRNTGTADGSGGNSASSLTSLSIVGPPFKIEKNGDCAQETVSPNSSSISNSSFSRNPPAKLPGSGTGKREPANAAVSGTNGTNCVPKRNCSKSKQSTKLGDKTVSNRKDLKPGGPSKFLSRLSRDSGEHAFRVHGSVASPLGNEAEDTERKESVDLTEHSTDEDSACLSDDNLGRIGRRPEAGRNTERCASAENGESPDLDSEANSESSLGDEANDVNHVAPKKRWQRFNQSSARSNKHISRSREKGNLESAFGLNSHGFSLKGNECLGRRHSPHSKVLEADLTVQDYENHLDLVEKRLNVCGKPNNSVMDSETKLGNFAPQSEFSAQVHSERKRLRKPSKRLLEYAEEYDHLFAPKKKSRKSQEQLRKVNSVARSGFEGGLPAQRSPDRETQRGPSPLVSTPFSTKESPPILEAECSFSELEPHASDPSEQLIEGQSDFPELVLSSSDVSEVSASPDAEERFLKSGNFESKRQRKPTKKLLESNDLDTAFMPKKEEWTPPKKGTGPSESDSLELYSPAHFPDLGEASEKLLEKQRKRKRPRHSSAAVHSKKEKNGERLGETPRSEGETLVHGTSTSPKGGHEDGSENDHGVPSSKKIQGERGGGAALKENVCQICEKPGELLLCEAQCCGAFHLQCLGLSEMPTGKFICNECSTGVHTCFVCKNCGQDVKRCLLPLCGKYYHEECIQKYPPTVTQNKGFRCSLHICMTCHAANPTNISASKGRLMRCVRCPVAYHSNDFCLAAGSVVLASNSIICPNHFTARRGCRNHEHVNVSWCFVCSEGGSLLCCESCPAAFHRECLNIEMPEGSWYCNDCKAGKKPHYKEVVWVKVGRYRWWPAEICHPRTIPVNIQKMKHDIGEFPVLFFGSKDYLWTHQARVFPYMEGDVSSKDKMGKGVDGIYKKALHEAAVRFEELKAQKELRQLQEDKKNDKKPPPYKHIKVNRPVGKVQIFTADLSEIPRCNCKPTDENPCGLDSECINRMLLYECHPLVCPAGERCQNQCFSKRQYPEVQIFRTLARGWGLQAKTDIRKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWCVNGDTRVGLFAIVNIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKSQPTLSEEKSKKLKRRPQMKRRSQAEVMKEREDECFSCGDGGQLVSCKKAGCPKVYHADCLNLTKRPAGKWECPWHQCDMCGKEAASFCEMCPRSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIREYVPPMGALTNGDDTQPPEQPPADTDPSIQPLDRLPQSVAFKLQSPEKPPATLALRLPPSEKPPTTLALRVQPSNKPPTTLALRLPPPDKPPAALALRLPPSNKPPTTLSLRLKPSNKPPTTLSLRLQPSDKPPTTLSLRLQPSDRPQAALSLRLQPEKQPVILALKPQQPDKPPTNAVLWPLDESSGDASEPHLPSKSPPGTPHSLDGSLVPAGALLQLSDEPPAIAEVLELSDKSLIDTETQEIELLDEFPAKCLHPQLSDRLLATAGTLQSQPVDEPPVAEQPQLLSKASAQSPQPQPAEKSPSSAIPHIPASEEILSPDVEVLWPLPIENVPTSPVSRILPMEKAPGLGVLRLPPPEKASFSGAVRVSAVEKAPSSGALHAFAPEKAPASGMPRILPSDKGPSLGVSWPLSLEKAHGSRSPHILPTDKALGSGALRIPLMQKVLSPGVLRPLPLEKAADAGALRPLPLEKALGSGVARPQLLERPPSLTATWPQASDKLAAAVAPRPQALDKPPAASAPRLLLSEKALRPVDQNAQPKERGAPAAELSPQQKERTMLAGEQISWSAGKAVAHVGQVPWPTEKLQTHEQSHWPTAKALTPAEQSPRTAEKLPEPTLQPSWEVASVPAEQTPWTSERLRVFEQTPRPAREAPVPQEQTQWIVTNIQTIEQISWLSGKVHIPRGQDPLPEQNTALAHNQDSVCHELADSEPK", "length": 2829 }, "evidence": [ { "id": "Q96L73", "url": "https://omabrowser.org/oma/group/Q96L73/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ACD6B642-1", "protein_name": "Histone-lysine N-methyltransferase, H3 lysine-36 specific", "gene_name": "nsd1a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MNQSYKVAGRDGSECRGDPQDSRALDVRIGSCGQQSTKADQSSAMHFLNPGYKLSAPFAYNQRESTSNYSPLRRLQDLTTMVNHADGGLQDKDFHGRNKLLMHSPIGGNEFGIGLYNTTNSQGNTAIQDLDKNGFSPVSSDSLEHFSPISNGFLHFDSTLFDSGDSKDNDEDVKGEVATFKDTSKKCQKRNVAKTKTQSSHRLDANKHSSKNTAKSDPPASPFHVPFTMMEDFDSMDDYSDSDCDLPSTENCASIFNLSKRAHSPSDSHSNPSSSPKKKQLLSVKYSIGDVVWAKFNRRPWWPCHVTTDPQIDVHTKMKDPSRRPCRLYFVRMFGEIVDQAWVPAKATFPFEGGDQFEKLPVLRRRGRQKEKDYKYTVPKRLIPSWKASVLEAEASLTKQLNSEPPLTLIQDVCVPITEDKAHKKNPACPKSTTLSTPSSSLLSNGLNASVKNRLKPGTASKKKATKKMIQSQSIKLSETPSLFKSKSNPSSDKPSIATDPLDSPYSDIDSVPRILCSKRIDESLQVELEKELSTKTTKVQACKKTSKNSVDKPGKKTDVKCLKNSKLKKSTPKDKTLKATSSRLKESSSPGSSDGSFAMHSHYLPASSGLIVRALAAGEETKEKDLSHEPNSHSPSSEHSSPTNHELSKQNWEVKNKSESSEESADASDSPPNPTSIKRIKKRPQKNGIHKDPPPKSHEESESKVNNESMFSDTSSSSIPSPSISPMDAFQDIKELSFRSLVKEECSSGESPLRADSNYKFSTFLMLLKDLHDSREKEGKPLTLPPTSPSSLIKEEPSLIPVGEEPPNEVLCEKEFAEQSSLPGKTSTPNNSKQSKAKLKSTVKKESQKPDIVIDSVSPLKKPISPVGLDVLDKSLPLLGDLPKSSDVSAAVTDVCAKGTISKVAPKKRWKTFESELGKSIKPKSDQVDSTLDEVKSVSTEPNGVFKDGLQESAHSDVPNKKDASENKRLRKPSKRLIECGEEYEQIFPSKKKTKKSTESCKTGSCISNTTPEQPASDQITPDAVSSSSAEKPLDHDVAEEQKPPADVLVPPSAPKSPSCATSLETEPCEKKSAPLERKRPRKSVHKVLDCAIEGESVKIPKKGESRQHKTNPEESGVRDLEKQEEAGPPPSSPCAVSAQSEGELRTSSPIQPDVPSVSQIPVEGEQSSPSKPQMNNEDSLISEGFGAGLNDSAFSSRDSLSGDLSGLSTNKRSVERGGGASLKENVCQVCEKTGELLLCEGQCCGAFHLQCIGLTETPKGRFICQECKMGVHTCFVCKKPDKEVRRCMIPVCGKFYHMDCILKYSPTVAQNRGFRCSIHVCLSCYITNPNNPGISKGRLTRCVRCPVAYHANDYCMAAGSVPLANNSFLCPNHFTPRKGCKNHEHINVSWCFVCSEGGSLLCCESCPAAFHRECLNIEMPQGSWFCNDCRAGKKPHYKDILWVKVGRYRWWPAEVTQPKSVPENISRMKHEVGEFPVHFFGSKDYVWTYQARCFPYMEGDANNKEKMGKGADAVYKKALNEAADRFRELLKEKEMRQLQEDRKNDKKPPPYKHIKVNKQIGKVLIITADLSEIPRCNCKATDENPCGIDSECINRMLLYECHSQVCPAGERCQNQSFTKRQYTEVEIFRTLSRGWGLRSISDIKKGAFVNEYVGEVIDEEECRSRIKNAQDNDICNFYMLTLDKDRIIDAGPKGNESRFMNHSCQPNCETQKWTVNGDTRVGLFALEDIPKGVELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPPSDDKTRKLRRKVSGKRKSQSEVTKEREDECFYCGDGGQIVSCKKPGCPKVYHADCLNLSKRPAGRWECPWHQCNECGREAASYCEMCPNSYCEQHREGMLFISKLDGKLSCSEHDPCGPDPLEPGEIREYVPSTSIVGQAPNMSASGRITQPALPPAAPLFIPAQNRPAFQSQRDPYGDEVVDNILPSSSPKDIKEEDMSDGEVVFEEEEEDLELVDDEEDEEEIDCRGMGLEDEEEEEEEFEDYEDDFVNVDFVGTEDGDEVEGDEQETSWDELVEAEK", "length": 2053 }, "evidence": [ { "id": "HGNC:14234", "url": "https://alliancegenome.org/gene/HGNC:14234#orthology", "database": "AGR" }, { "id": "MGI:1276545", "url": "https://alliancegenome.org/gene/MGI:1276545#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-080519-3", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-080519-3#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D4A9J4-1", "protein_name": "Histone-lysine N-methyltransferase NSD2", "gene_name": "Nsd2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEFSIRKSPLSVQKVVKCMKMKQAPEILGSANGKTQNCEVNHECSVFLSKAQLSNSLQEGVMQKFNGHDALPFLPAEKLKDLTSCVFNGEPGAHDTKLCFETQEVKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDGAADMSQSEENGQKSDNKTRRNRKRSIKYDSLLEQGLVEAALVSKISSPEDKKIPVKKESCPNSGRDRDLLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHNHTKLKGQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEEQFEKLCQESAKQAPTKAEKIKLLKPISGRLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLRLNPQVAKEAGIATEPLGEMVDSSVANEEAAVDPGTMREEDIPVKRRRRAKRSSSAENQEGDPGTEKSTPPKMADAEPKRGVGSPAGRKRSTGSASRSRKGDSAAQFLVFCQKHRDEVVAEHPDASEEEIEELLGSQWSMLNEKQKARYNTKFSLMISAQSEEDSGNTSGKKRTHTKRTDDPPEDVDVEDAPRKRLRTDKHSLRKRETITDKTARTSSYKAIEAASSLKSQAATKNLSDACKPLKKRNRASATASSALGFNKSSSPSASLTENEVSDNPGDEPSESPYESADETQTEASVSSKKSERGMAAKKEYVCQLCEKTGSLLLCEGPCCGAFHLACLGLSQRPEGRFTCTECASGIHSCFVCKESKMEVKRCMVNQCGKFYHEACVKKYPLTVFESRGFRCPLHSCMSCHASNPSNPRPSKGGSLLCCEACPAAFHPDCLSIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFNEIKLQREARETQESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGSDSECLNRMLMFECHPQVCPAGEYCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKYAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSTSLSSEEKSKKAKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFRSTQDGQSYCCEHDLRADSANNTKTEKPFLDSLKAKGKRKKRRCWRRVTDGK", "length": 1305 }, "evidence": [ { "id": "FB:FBgn0039559", "url": "https://alliancegenome.org/gene/FB:FBgn0039559#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E1BM66-1", "protein_name": "Histone-lysine N-methyltransferase, H3 lysine-36 specific", "gene_name": "NSD1", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTASGTSQNAYGQDSPSCYIPLRKLQDLASMINVEYLNGSADGSESFQDPEKSDSRAQSPVVCTSLNPGGPTALAMKQEPSCNNSPELQVKVTKTVKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESIEEIFEETQTNATCNYEPKSENGVDVAMGDEQDSTPDSRHGAGKPPFLPLAPQTETQRNKQRSDVDGSHEKAALLPAPLSLGDTNVTIEEQLNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKATPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDIPKGSKNRKCVTSSIKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHMQFETHKEERRGKIPENLGLNFISGDVSDKQASNELSRIANSLTGPSTAPGSFLFSSCAKNTAKKEFETSNCDSLLGLSEGALISKRSGEKKKFQRGLMCSSKVQLCYIGAGDEEKRSDSISICTTSDDGSSDLDPVDHSSESDNSVLEITDAFDRSENLLPVQKNEKVKYSRYPATNTKVKAKQKSLITNSHTDHLINCTKTTEPGTETSQINLSDLKVSTLVRKPQPDFRNDGFSPKFNTSSSISSENSIIKGGAKNQALLHSKSKQPKIRSIKCKHKENPVVAEPPVANEDCSLKCCSSDNKGSPLASISKSGKVDGLKLLSNMHEKTRDSSDIETAVVKHVLSELKELSYRSLSEDVSDSGTSKPSKPLLFSSASGQNHIPIEPDYKFSTLLMMLKDMHDSKTKEQRIMTAQNLVSYRSPGLGDCSTSSPVSAPKVLVSGGSNHSSEKSGDGTQDPVHPGPGGGDSALSGELSTSLPGLGSDKRDLPASGKNRSNCVTRRNCGRSKPSKFRDGFSAQMGKNTVNRKALKTERRRKLNELPAVTLEAALQGDRESRGSEKSSSRGEAEDPGKEPTLQLMGHLTSEDGAHFSSVSFDNKVNQSDPEKIPEKGPSFEIRKVPELDSEMNSENDEPSSINEAVPKKRWQRLNQRRTKPRKRTNRFKEKENSEGAFGVLLSADPVKKEDEFPEQRPPASTNKLEDALTDPNHANHLDSAGPRLNVCDKSNASNEEMEKEPGIPSLTPQPELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKTQEQVHKVSSRCEEESLLARCRSSAQNKQVDENSLISTKEEPPVLEREAPFLEGPLAQSELGGGHAELPQLTLSVPVAPEVSPRPALESEELLVKPPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLTKKCYEAGHLENDINESCAAPRSKEFGGGTTKLFDKPRKRKRQRHATAKLHCKKVKNDISSKETPNSEGELMTHRTAASPKETVEEGVENDHGMPASKKLQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRCSLHICTTCHAANPASVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFTKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRTQGEVTKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIREYVPPPVPLPPGPSTHLAEQSSGVAAQGPKMSDKPSADTNPSLSLSKKALAGTCQRPPLPERPPDRTDSRPQPVDRVRDLAGSGTKPQSLVSSQKPLDRPPAVAGPRPQLSDKPSPVTGPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTPVPTGLRLPPPEKLLVTSGPKPQTSDRPPDKSHVSLSQRLPPPDKVLSAVVQTLVAKEKALRPVDQNTQSKNRAALVMDLIDLTPRQKDRAGSPHELTPQADEKMPVLESSSWPASKGLGQIPRAVERGSVSDAVLQPLGKAAATSEHSWQAVKSLTQARLLSQPPAKAFLYEPATQASGRAPAGAEQTPGPPSQAPGLVKQVKQMAGGQQLPGLAAKSGQSFRPLGKSSLSTEEKKLAPTEQSPWALGKASPGPGLWPMVAGQTLAQSCWSSGSTQTLAQTCWSLGRGKDPKPEQSTLPALNQAPSSHKCAESEQK", "length": 2698 }, "evidence": [ { "id": "Q96L73", "url": "https://omabrowser.org/oma/group/Q96L73/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "O88491-1", "protein_name": "Histone-lysine N-methyltransferase, H3 lysine-36 specific", "gene_name": "Nsd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDRTCELSRRNCLLSFSNPVNLDASEDKDSPFGNGQSNFSEPLNGCTMQLPTAASGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLSGSADGSESFQDPAKSDSRAQSPIVCTSLSPGGPTALAMKQEPTCNNSPELQLRVTKTTKNGFLHFENFTGVDDADVDSEMDPEQPVTEDESIEEIFEETQTNATCNYEPKSENGVEVAMGSEQDSMPESRHGAVERPFLPLAPQTEKQKNKQRSEVDGSNEKTALLPAPTSLGDTNVTVEEQFNSINLSFQDDPDSSPSPLGNMLEIPGTSSPSTSQELPFVPQKILSKWEASVGLAEQYDVPKGSKNQKCVSSSVKLDSEEDMPFEDCTNDPDSEHLLLNGCLKSLAFDSEHSADEKEKPCAKSRVRKSSDNIKRTSVKKDLVPFESRKEERRGKIPDNLGLDFISGGVSDKQASNELSRIANSLTGSSTAPGSFLFSSSVQNTAKTDFETPDCDSLSGLSESALISKHSGEKKKLHPGQVCSSKVQLCYVGAGDEEKRSNSVSVSTTSDDGCSDLDPTEHNSGFQNSVLGITDAFDKTENALSVHKNETQYSRYPVTNRIKEKQKSLITNSHADHLMGSTKTMEPETAELSQVNLSDLKISSPIPKPQPEFRNDGLTTKFSAPPGIRNENPLTKGGLANQTLLPLKCRQPKFRSIKCKHKESPAVAETSATSEDLSLKCCSSDTNGSPLANISKSGKGEGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLSEDVSDSGTAKASKPLLFSSASSQNHIPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLASYRTPDRGDCSSGSPVGTSKVLVLGSSTPNSEKPGDSTQDSVHQSPGGGDSALSGELSSSLSSLASDKRELPACGKIRSNCIPRRNCGRAKPSSKLRETISAQMVKPSVNPKALKTERKRKFSRLPAVTLAANRLGNKESGSVNGPSRGGAEDPGKEEPLQQMDLLRNEDTHFSDVHFDSKAKQSDPDKNLEKEPSFENRKGPELGSEMNTENDELHGVNQVVPKKRWQRLNQRRPKPGKRANRFREKENSEGAFGVLLPADAVQKAREDYLEQRAPPTSKPEDSAADPNHGSHSESVAPRLNVCEKSSVGMGDVEKETGIPSLMPQTKLPEPAIRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEDESLLARCQPSAQNKQVDENSLISTKEEPPVLEREAPFLEGPLAQSDLGVTHAELPQLTLSVPVAPEASPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLSRKCFEASRSGNGIVESRATSHLKEFSGGTTKIFDKPRKRKRQRLVTARVHYKKVKKEDLTKDTPSSEGELLIHRTAASPKEILEEGVEHDPGMSASKKLQVERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLECLGLPEMPRGKFICNECHTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVTQNKGFRCPLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKARKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGVRCQNQCFSKRQYPDVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIVTEEKSRKFKRKPHGKRRSQGEVTKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDVCGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIREYVPPTATSPPSPGTQPKEQSSEMATQGPKKSDQPPTDATQLLPLSKKALTGSCQRPLLPERPPERTDSSSHLLDRIRDLAGSGTKSQSLVSSQRPQDRPPAKEGPRPQPPDRASPMTRPSSSPSVSSLPLERPLRMTDSRLDKSIGAASPKSQAVEKTPASTGLRLSSPDRLLTTNSPKPQISDRPPEKSHASLTQRLPPPEKVLSAVVQSLVAKEKALRPVDQNTQSKHRPAVVMDLIDLTPRQKERAASPQEVTPQADEKTAMLESSSWPSSKGLGHIPRATEKISVSESLQPSGKVAAPSEHPWQAVKSLTHARFLSPPSAKAFLYESATQASGRTPVGAEQTPGPPSPAPGLVKQVKQLSRGLTAKSGQSFRSLGKISASLPNEEKKLTTTEQSPWGLGKASPGAGLWPIVAGQTLAQACWSAGGTQTLAQTCWSLGRGQDPKPENAIQALNQAPSSRKCADSEKK", "length": 2588 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-080519-2", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-080519-2#orthology", "database": "AGR" }, { "id": "HGNC:14234", "url": "https://alliancegenome.org/gene/HGNC:14234#orthology", "database": "AGR" }, { "id": "MGI:1276545", "url": "https://alliancegenome.org/gene/MGI:1276545#orthology", "database": "AGR" }, { "id": "RGD:1307748", "url": "https://alliancegenome.org/gene/RGD:1307748#orthology", "database": "AGR" }, { "id": "FB:FBgn0039559", "url": "https://alliancegenome.org/gene/FB:FBgn0039559#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-080519-3", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-080519-3#orthology", "database": "AGR" }, { "id": "Q96L73", "url": "https://omabrowser.org/oma/group/Q96L73/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "O96028-1", "protein_name": "Histone-lysine N-methyltransferase NSD2", "gene_name": "NSD2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVFNGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDSLLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNPQVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVSMPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTEDAEAEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENEVSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSCFVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFREIKLQREARETQESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSTTLSSEEKGKKTKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFSCTPDGRSYCCEHDLGAASVRSTKTEKPPPEPGKPKGKRRRRRGWRRVTEGK", "length": 1365 }, "evidence": [ { "id": "FB:FBgn0039559", "url": "https://alliancegenome.org/gene/FB:FBgn0039559#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P46995-1", "protein_name": "Histone-lysine N-methyltransferase, H3 lysine-36 specific", "gene_name": "SET2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSKNQSVSASEDEKEILNNNAEGHKPQRLFDQEPDLTEEALTKFENLDDCIYANKRIGTFKNNDFMECDCYEEFSDGVNHACDEDSDCINRLTLIECVNDLCSSCGNDCQNQRFQKKQYAPIAIFKTKHKGYGVRAEQDIEANQFIYEYKGEVIEEMEFRDRLIDYDQRHFKHFYFMMLQNGEFIDATIKGSLARFCNHSCSPNAYVNKWVVKDKLRMGIFAQRKILKGEEITFDYNVDRYGAQAQKCYCEEPNCIGFLGGKTQTDAASLLPQNIADALGVTVSMEKKWLKLKKLSGEPIIKNENENINIEFLQSLEVQPIDSPVDVTKIMSVLLQQDNKIIASKLLKRLFTIDDDSLRHQAIKLHGYTCFSKMLKLFITEQPQVDGKGNETEEDDIKFIKGILDFLLELPKTTRNGIESSQIDNVVKTLPAKFPFLKPNCDELLEKWSKFETYKRITKKDINVAASKMIDLRRVRLPPGWEIIHENGRPLYYNAEQKTKLHYPPSGSSKVFSSRSNTQVNSPSSSGIPKTPGALDSKKHKLSDEEYERKKQKRLEYERIALERAKQEELESLKQKLKLENERKSVLEDIIAEANKQKELQKEEAKKLVEAKEAKRLKRKTVSQSQRLEHNWNKFFASFVPNLIKKNPQSKQFDHENIKQCAKDIVKILTTKELKKDSSRAPPDDLTKGKRHKVKEFINSYMDKIILKKKQKKALALSSASTRMSSPPPSTSS", "length": 733 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-080519-2", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-080519-2#orthology", "database": "AGR" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q6P2L6-1", "protein_name": "Histone-lysine N-methyltransferase NSD3", "gene_name": "Nsd3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNHSDIVEDGGPTPFEATLQQGFQYPPTTEDLPPLTNGYPPSISLYETQTKYPPYNQYPNGSANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEVQASEHTKSKHESRKEKRKKSNRHESSRSEERRSHKIPKLEPEGQNRPNERVDTAPEKPREEPVLKEAIPVQPILSSVPTTETSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHSKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHEQYEELLAEAAKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERVEQYTFIYIDKQPEEASSQAKKNVTSKTEVKKPRRPRSVLNSQPEQTNAGEVASSQSSTDLRRQSQRRHTSLEEEEPPPVKIAWKTAAARKSLPASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISSPSQRSEKPAQSASSPEATSGSAGPVEKKQQRRSIRTRSESEKSAEVVPKKKIKKEQVETAPQASLKTGLQKGASEISDSCKPLKKRSRASTDVETASCTYRDTSDSDSRGLSDGQVGFGKQVDSPSATADADASDAQSVDSSLSRRGVGTSKKDTVCQVCEKAGDCLVACEGECCRHFHVECLGLTAVPEGHFTCEECETGQHPCFSCKVSGKDVKRCSVSVCGKFYHEACVRKFPTAIFESKGFRCPQHCCSSCSMEKDIHKASKGRMMRCLRCPVAYHVGDACVAAGSVSVSSHILICSNHSKRSSQSAAINVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLSESNRAELMKLPMIPSSSASKKRCEKGGRLLCCESCPASFHPECLSIDMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRQVLWWPAEICSPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKHFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEMERTSRKPPPYKHIKANKVIGKVQVQVADLSEIPRCNCKPGDENPCGLESQCLNRMSQYECHPQVCPAGDRCQNQCFTKRLYPDAEVIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTVCHCGADNCSGFLGVRPKSACTSAVDEKTKNAKLKKRRKVKAEAKPIHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPHGKWECPWHRCDECGSVAVSFCEFCPHSFCKAHGKGALVPSALEGRLCCSSHDPASPVSPEYWSKIRCKWESQDSGEEVKE", "length": 1439 }, "evidence": [ { "id": "FB:FBgn0039559", "url": "https://alliancegenome.org/gene/FB:FBgn0039559#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8BVE8-1", "protein_name": "Histone-lysine N-methyltransferase NSD2", "gene_name": "Nsd2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEFSIRKSPLSVQKVVKCMKMKQTPEILGSANGKTQNCEVNHECSVFLSKAQLSNSLQEGVMQKFNGHDALPFLPAEKLKDLTSCVFNGEPGAHDTKLCFEAQEVKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDGAADVSQSEENEQKSDNKTRRNRKRSIKYDSLLEQGLVEAALVSKISSPADKKIPVKKESCPNTGRDRDLLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHNHTKLKGQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEEQFEKLCQESAKQAPTKAEKIKLLKPISGRLRAQWEMGIVQAEEAASMSIEERKAKFTFLYVGDQLHLNPQVAKEAGIVTEPLGEMVDSSGASEEAAVDPGSVREEDIPTKRRRRTKRSSSAENQEGDPGTDKSTPPKMAEAEPKRGVGSPAGRKKSTGSAPRSRKGDSAAQFLVFCQKHRDEVVAEHPDASGEEIEELLGSQWSMLNEKQKARYNTKFSLMISAQSEEDSGNGNGKKRSHTKRADDPAEDVDVEDAPRKRLRADKHSLRKRETITDKTARTSSYKAIEAASSLKSQAATKNLSDACKPLKKRNRASATASSALGFNKSSSPSASLTEHEVSDSPGDEPSESPYESADETQTEASVSSKKSERGMAAKKEYVCQLCEKTGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCTECASGIHSCFVCKESKMEVKRCVVNQCGKFYHEACVKKYPLTVFESRGFRCPLHSCMSCHASNPSNPRPSKGKMMRCVRCPVAYHGGDACLAAGCSVIASNSIICTGHFTARKGKRHHTHVNVSWCFVCSKGGSLLCCEACPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFNEVKLQREARETQESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGSDSECLNRMLMFECHPQVCPAGEYCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKYAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSASLSSEEKGKKAKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFRSTQDGQSYCCEHDLRADSSSSTKTEKPFPESLKSKGKRKKRRCWRRVTDGK", "length": 1365 }, "evidence": [ { "id": "FB:FBgn0039559", "url": "https://alliancegenome.org/gene/FB:FBgn0039559#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8MT36-1", "protein_name": "Nuclear receptor binding SET domain protein", "gene_name": "NSD", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MKLSTDAHSEIEGDAAHGNVLCNSASDSLTATDEVAAGNDESVATEGDDVEIPRDTNNSTPVRLLDKPGQNPVQNGAQPAAEESELESQRQTPVQKQQQQRVSMVNRKRDLINLQSALSPKYIGYANANSPTPLSDSDDTIRTTRRRVNQAAALNNSSAGETLAHDNASPRTPGGGGGGGGDDSANQLLSKTYMSPIEKLLIKNGASSPNSTGFEAGSEDLGIRPIVRKHVKRKMKRVPKAKVTLELDEKNQQEVDEKSVKTEPIDEEVDRTDEAPTQEAQTTAISIKSETEAEHKAAVDVHIKQEDTIRLDIVNNPVESTSIVITEEPKDLEKSTEELAFALPLASSTEVDLKSPPDLSSTALATSIKSPSSVSIDSAKGLSIVTDPGWPTYQVGDLFWGKVFSYCFWPCMVCPDPLGQIVGNMPSHPQRSSLDNANVPIQVHVRFFADNGRRNWIKPENLLTFAGLKAFDDMREELRIKHGPKSAKYRQMVPKRTKVVIWRQAIEEAQAMTQIPYSDRLEKFYQTYENVVTLNRQKRKRTKYMMQDTSDVGSSLYDSTDNLHNKQGTQLLAVKRERSESPFSPAFSPVKSKNEKRAKRRKLSNGTEADTGSNSMAVTPSQTETTVDSSAYENPEFRQLLSAVMEYVMMNRSDEKVEKVLLSVVSNIWSLKQIQLRELERDLASGEIEEPLGSSVVGRGSGVGTIKRLSNRLMTMMVRRSMTPVVTPSTTPAPSEPDRRLSEPPKTKKPVNRPIEEVIEDILQLDSKYLFRGLSREPICKYCYQAGSDLVRCSRTCSSWLHADCLERKVTGAPMPKIGSRKALVIPPTSKSPSPDEDHVTADAKEVVAVGTSLVCHECNVGEPEGCVICHQVESPAVPSTPRKEDSSSHTPIEDKLLTCSQPMCGKRFHTSCCKYWPQASSSKHSARCPRHVCHTCVSDDPSGKFQQLGSSKLAKCVRCPATYHQLSKCIPAGTQMLNTTNIICPRHNIAKADAHVNVLWCYICVKGGELVCCETCPIAVHAHCRNIPIKTNESYICEECESGRLPLYGEIVWAKFNNFRWWPAIILPPTEVPSNILKKAHGENDFVVRFFGTHDHGWISRRRVYLYIEGDTGDGHKTKSQLFRNYTTGVEEASRFLPIIKARRQEQDMERQSGNKLHPPPYVKIKTNKAVPPLRFSQNLEDLSTCNCLPVDEHPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPRLEVVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCGAKRCSGEIGGKLKDDAVKAHAKLKQMRRAKASAVRIHVKPKKTPKVKHISADDEPMDAKDE", "length": 1427 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-080519-2", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-080519-2#orthology", "database": "AGR" }, { "id": "HGNC:14234", "url": "https://alliancegenome.org/gene/HGNC:14234#orthology", "database": "AGR" }, { "id": "MGI:1276545", "url": "https://alliancegenome.org/gene/MGI:1276545#orthology", "database": "AGR" }, { "id": "RGD:1307748", "url": "https://alliancegenome.org/gene/RGD:1307748#orthology", "database": "AGR" }, { "id": "FB:FBgn0039559", "url": "https://alliancegenome.org/gene/FB:FBgn0039559#orthology", "database": "AGR" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9BZ95-1", "protein_name": "Histone-lysine N-methyltransferase NSD3", "gene_name": "NSD3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIAEDGGQTPYEATLQQGFQYPATTEDLPPLTNGYPSSISVYETQTKYQSYNQYPNGSANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEVQASEHTKSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLPASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPLKKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVGFGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKRRKIKTEPKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHDPMAPVSPEYWSKIKCKWESQDHGEEVKE", "length": 1437 }, "evidence": [ { "id": "FB:FBgn0039559", "url": "https://alliancegenome.org/gene/FB:FBgn0039559#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "pmid": "" }, { "name": "regulation of peptidyl-serine phosphorylation", "id": "GO:0033135", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033135", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "pmid": "" }, { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "pmid": "" }, { "name": "regulation of RNA polymerase II regulatory region sequence-specific DNA binding", "id": "GO:1903025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903025", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 15, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "pmid": "" }, { "name": "transcription corepressor activity", "id": "GO:0003714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "pmid": "" }, { "name": "nuclear estrogen receptor binding", "id": "GO:0030331", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030331", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "pmid": "" }, { "name": "nuclear retinoic acid receptor binding", "id": "GO:0042974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042974", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "pmid": "" }, { "name": "nuclear thyroid hormone receptor binding", "id": "GO:0046966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046966", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "pmid": "" }, { "name": "nuclear androgen receptor binding", "id": "GO:0050681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050681", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "pmid": "" }, { "name": "transcription coregulator activity", "id": "GO:0003712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "pmid": "" }, { "name": "nuclear retinoid X receptor binding", "id": "GO:0046965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046965", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "pmid": "" }, { "name": "histone H3K36 methyltransferase activity", "id": "GO:0046975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046975", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "pmid": "" }, { "name": "histone H4K20 methyltransferase activity", "id": "GO:0042799", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042799", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "pmid": "" }, { "name": "histone H3 methyltransferase activity", "id": "GO:0140938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140938", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "pmid": "" }, { "name": "histone H3K36 dimethyltransferase activity", "id": "GO:0140954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140954", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "pmid": "" }, { "name": "nuclear receptor binding", "id": "GO:0016922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016922", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "Q96L73", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 133, "end_pos": 135, "annotation": "n_glycosylation_sequon" }, { "start_pos": 155, "end_pos": 157, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1650, "end_pos": 1652, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1706, "end_pos": 1708, "annotation": "n_glycosylation_sequon" }, { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2076, "end_pos": 2078, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2148, "end_pos": 2150, "annotation": "n_glycosylation_sequon" }, { "start_pos": 264, "end_pos": 266, "annotation": "n_glycosylation_sequon" }, { "start_pos": 275, "end_pos": 277, "annotation": "n_glycosylation_sequon" }, { "start_pos": 38, "end_pos": 40, "annotation": "n_glycosylation_sequon" }, { "start_pos": 729, "end_pos": 731, "annotation": "n_glycosylation_sequon" }, { "start_pos": 756, "end_pos": 758, "annotation": "n_glycosylation_sequon" }, { "start_pos": 88, "end_pos": 90, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "60308", "name": "", "equation": "L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O96028-1", "Q96L73-1", "Q53H47-1" ], "evidence": [ { "id": "60308", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/60308" } ] }, { "id": "R-HSA-4827383", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)", "equation": "", "summary": "Methylation of histone H3 lysine-37 (H3K36) is tightly associated with actively transcribed genes and appears to correspond primarily with coding regions (Wagner & Carpenter 2011).

WHSC1 (KMT3G, NSD2, MMSET), a member of the SET2 family, dimethylates H3K36 when provided with nucleosome substrates (Li et al 2009; Qiao et al. 2011). Dimethylation of histone H3 at lysine-37 (H3K36me2) is thought to be the principal chromatin-regulatory activity of WHSC1 (Kuo et al. 2011), SMYD2 (KMT3C) (Brown et al 2006) and NSD1 (KMT3B) (Li et al. 2009, Qiao et al. 2011).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O96028-1", "Q9NR48-1", "Q9NRG4-1", "Q96L73-1" ], "evidence": [ { "id": "R-HSA-4827383", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4827383" } ] }, { "id": "R-HSA-5638157", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36)", "equation": "", "summary": "Methylation of histone H3 lysine-37 (H3K36) is tightly associated with actively transcribed genes and appears to correspond primarily with coding regions (Wagner & Carpenter 2011).; ; WHSC1 (KMT3G, NSD2, MMSET), a member of the SET2 family, dimethylates H3K36 when provided with nucleosome substrates (Li et al 2009; Qiao et al. 2011). Dimethylation of histone H3 at lysine-37 (H3K36me2) is thought to be the principal chromatin-regulatory activity of WHSC1 (Kuo et al. 2011), SMYD2 (KMT3C) (Brown et al 2006) and NSD1 (KMT3B) (Li et al. 2009, Qiao et al. 2011). ASH1L can perform histone H3 lysine-37 di-methylation (Tanaka et al. 2007, An et al. 2011, Miyazaki et al. 2013, Zhu et al. 2016).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O96028-1", "Q9NR48-1", "Q9NRG4-1", "Q96L73-1" ], "evidence": [ { "id": "R-HSA-5638157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5638157" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "O96028", "gene_name": "NSD2", "activity": [ { "ec_number": "2.1.1.357", "activity": "L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H(+).", "evidence": [ { "id": "O96028", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O96028" } ] }, { "ec_number": "2.1.1.357", "activity": "", "evidence": [ { "id": "O96028", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O96028" } ] } ] }, { "uniprot_ac": "Q53H47", "gene_name": "SETMAR", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "Q53H47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q53H47" } ] }, { "ec_number": "2.1.1.357", "activity": "L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H(+).", "evidence": [ { "id": "Q53H47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q53H47" } ] } ] }, { "uniprot_ac": "Q96L73", "gene_name": "NSD1", "activity": [ { "ec_number": "2.1.1.357", "activity": "L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H(+).", "evidence": [ { "id": "Q96L73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ] }, { "ec_number": "2.1.1.357", "activity": "", "evidence": [ { "id": "Q96L73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96L73" } ] } ] }, { "uniprot_ac": "Q9NR48", "gene_name": "ASH1L", "activity": [ { "ec_number": "2.1.1.359", "activity": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+).", "evidence": [ { "id": "Q9NR48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9NR48" } ] }, { "ec_number": "2.1.1.367", "activity": "L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "Q9NR48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9NR48" } ] }, { "ec_number": "2.1.1.367", "activity": "", "evidence": [ { "id": "Q9NR48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9NR48" } ] }, { "ec_number": "2.1.1.359", "activity": "", "evidence": [ { "id": "Q9NR48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9NR48" } ] } ] }, { "uniprot_ac": "Q9NRG4", "gene_name": "SMYD2", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "Q9NRG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9NRG4" } ] }, { "ec_number": "2.1.1.354", "activity": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+).", "evidence": [ { "id": "Q9NRG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9NRG4" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q96L73-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 2696, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q96L73-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q96L73" }, { "pdb_id": "3ooi", "pdb_chain": "a", "start_pos": 1852, "end_pos": 2082, "overlap": 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