[ { "uniprot_canonical_ac": "Q8TD57-1", "uniprot_ac": "Q8TD57", "uniprot_id": "DYH3_HUMAN", "mass": { "chemical_mass": 470771.0, "monoisotopic_mass": 470771.0 }, "refseq": { "ac": "NP_001334815", "name": "dynein axonemal heavy chain 3 isoform 2", "summary": "This gene belongs to the dynein family, whose members encode large proteins that are constituents of the microtubule-associated motor protein complex. This complex is composed of dynein heavy, intermediate and light chains, which can be axonemal or cytoplasmic. This protein is an axonemal dynein heavy chain. It is involved in producing force for ciliary beating by using energy from ATP hydrolysis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2016].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334815" }, "gene_names": [ { "name": "DNAH3", "type": "recommended", "evidence": [ { "id": "Q8TD57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8TD57" } ] }, { "name": "DNAH3", "type": "synonym", "evidence": [ { "id": "NP_001334815", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334815" } ] }, { "name": "DNAHC3-B", "type": "synonym", "evidence": [ { "id": "NP_001334815", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334815" } ] }, { "name": "DNAHC3B", "type": "synonym", "evidence": [ { "id": "NP_001334815", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334815" }, { "id": "Q8TD57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8TD57" } ] }, { "name": "HDHC8", "type": "synonym", "evidence": [ { "id": "NP_001334815", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334815" } ] }, { "name": "HEL-36", "type": "synonym", "evidence": [ { "id": "NP_001334815", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334815" } ] }, { "name": "HSADHC3", "type": "synonym", "evidence": [ { "id": "NP_001334815", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334815" } ] } ], "protein_names": [ { "name": "Dynein axonemal heavy chain 3", "type": "recommended", "evidence": [ { "id": "Q8TD57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8TD57/entry#names_and_taxonomy" } ] }, { "name": "Axonemal beta dynein heavy chain 3", "type": "synonym", "evidence": [ { "id": "Q8TD57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8TD57/entry#names_and_taxonomy" } ] }, { "name": "Ciliary dynein heavy chain 3", "type": "synonym", "evidence": [ { "id": "Q8TD57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8TD57/entry#names_and_taxonomy" } ] }, { "name": "Dnahc3-b", "type": "synonym", "evidence": [ { "id": "Q8TD57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8TD57/entry#names_and_taxonomy" } ] }, { "name": "HsADHC3", "type": "synonym", "evidence": [ { "id": "Q8TD57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8TD57/entry#names_and_taxonomy" } ] }, { "name": "axonemal beta dynein heavy chain 3", "type": "synonym", "evidence": [ { "id": "NP_001334815", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334815" } ] }, { "name": "axonemal dynein, heavy chain", "type": "synonym", "evidence": [ { "id": "NP_001334815", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334815" } ] }, { "name": "ciliary dynein heavy chain 3", "type": "synonym", "evidence": [ { "id": "NP_001334815", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334815" } ] }, { "name": "dynein axonemal heavy chain 3 isoform 2", "type": "synonym", "evidence": [ { "id": "NP_001334815", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334815" } ] }, { "name": "dynein heavy chain 3, axonemal", "type": "synonym", "evidence": [ { "id": "NP_001334815", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334815" } ] }, { "name": "dynein, axonemal, heavy polypeptide 3", "type": "synonym", "evidence": [ { "id": "NP_001334815", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334815" } ] }, { "name": "epididymis luminal protein 36", "type": "synonym", "evidence": [ { "id": "NP_001334815", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334815" } ] } ], "function": [ { "annotation": "Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Essential for the assembly and structural organization of the sperm flagellum's axoneme, including its inner dynein arms and accessory components, which are critical for maintaining flagellar integrity and motility (PubMed:39503742, PubMed:38312775).", "evidence": [ { "database": "UniProtKB", "id": "Q8TD57", "url": "https://www.uniprot.org/uniprotkb/Q8TD57#function" }, { "database": "PubMed", "id": "38312775", "url": "https://glygen.org/publication/PubMed/38312775" }, { "database": "UniProtKB", "id": "Q8VHE6", "url": "https://www.uniprot.org/uniprotkb/Q8VHE6#function" }, { "database": "PubMed", "id": "39503742", "url": "https://glygen.org/publication/PubMed/39503742" } ] }, { "annotation": "This gene belongs to the dynein family, whose members encode large proteins that are constituents of the microtubule-associated motor protein complex. This complex is composed of dynein heavy, intermediate and light chains, which can be axonemal or cytoplasmic. This protein is an axonemal dynein heavy chain. It is involved in producing force for ciliary beating by using energy from ATP hydrolysis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2016].", "evidence": [ { "database": "RefSeq", "id": "NP_001334815", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334815" } ] } ], "disease": [ { "disease_id": "DOID:0050989", "recommended_name": { "id": "DOID:0050989", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0050989", "name": "episodic ataxia type 1", "description": "An episodic ataxia that is characterized by periodic ataxia and frequent myokymic discharges, and has_material_basis_in autosomal dominant inheritance of mutation in the potassium channel gene KCNA1." }, "synonyms": [ { "id": "MONDO:0008047", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008047", "name": "episodic ataxia type 1", "description": "A frequent form of hereditary episodic ataxia characterized by brief episodes of ataxia, neuromyotonia, and continuous interictal myokymia." }, { "id": "MONDO:0008047", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008047", "name": "EA1", "description": "" }, { "id": "MONDO:0008047", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008047", "name": "Isaacs-Mertens syndrome", "description": "" }, { "id": "MONDO:0008047", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008047", "name": "KCNA1 hereditary episodic ataxia", "description": "" }, { "id": "MONDO:0008047", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008047", "name": "acetazolamide-responsive periodic ataxia", "description": "" }, { "id": "MONDO:0008047", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008047", "name": "ataxia, episodic, with myokymia", "description": "" }, { "id": "MONDO:0008047", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008047", "name": "continuous muscle fiber activity", "description": "" }, { "id": "MONDO:0008047", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008047", "name": "episodic ataxia with myokymia", "description": "" }, { "id": "MONDO:0008047", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008047", "name": "episodic ataxia, type 1", "description": "" }, { "id": "MONDO:0008047", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008047", "name": "episodic ataxia/myokymia syndrome", "description": "" }, { "id": "MONDO:0008047", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008047", "name": "familial paroxysmal kinesigenic ataxia and continuous myokymia", "description": "" }, { "id": "MONDO:0008047", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008047", "name": "hereditary episodic ataxia caused by mutation in KCNA1", "description": "" }, { "id": "MONDO:0008047", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008047", "name": "hereditary paroxysmal ataxia with neuromyotonia", "description": "" }, { "id": "MONDO:0008047", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008047", "name": "myokymia with episodic ataxia", "description": "" }, { "id": "MONDO:0008047", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008047", "name": "myokymia with periodic ataxia", "description": "" }, { "id": "MONDO:0008047", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008047", "name": "paroxysmal ataxia with neuromyotonia, hereditary", "description": "" }, { "id": "MIM:160120", "resource": "MIM", "url": "https://www.omim.org/entry/160120", "name": "Episodic ataxia 1", "description": "Episodic ataxia 1" } ], "unlinked_id_list": [], "evidence": [ { "id": "0050989", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050989" } ] }, { "disease_id": "DOID:1826", "recommended_name": { "id": "DOID:1826", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1826", "name": "epilepsy", "description": "A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions." }, "synonyms": [ { "id": "DOID:1826", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1826", "name": "epilepsy syndrome", "description": "" }, { "id": "DOID:1826", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1826", "name": "epileptic syndrome", "description": "" } ], "unlinked_id_list": [ "DOID:3331", "DOID:0050702", "DOID:0060172", "DOID:0050706", "DOID:0050705", "DOID:0050703", "DOID:0050701", "DOID:0060169" ], "evidence": [ { "id": "1826", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1826" } ] }, { "disease_id": "DOID:3328", "recommended_name": { "id": "DOID:3328", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3328", "name": "temporal lobe epilepsy", "description": "A focal epilepsy that is characterized by recurrent, unprovoked focal seizures that originate in the temporal lobe of the brain and last about one or two minutes." }, "synonyms": [ { "id": "DOID:3328", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3328", "name": "epilepsy, temporal lobe", "description": "" }, { "id": "MONDO:0700090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700090", "name": "epilepsy, familial temporal lobe, 1", "description": "An autosomal dominant condition caused by mutation(s) in the LGI1 gene, encoding leucine-rich glioma-inactivated protein 1. It is characterized by partial seizures originating in the temporal lobe and often accompanied by auditory sensory manifestations." }, { "id": "MONDO:0700090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700090", "name": "ADLTE", "description": "" }, { "id": "MONDO:0700090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700090", "name": "ADPEAF", "description": "" }, { "id": "MONDO:0700090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700090", "name": "ETL1", "description": "" }, { "id": "MONDO:0700090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700090", "name": "epilepsy, familial temporal lobe, type 1", "description": "" }, { "id": "MONDO:0700090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700090", "name": "epilepsy, lateral temporal lobe, autosomal dominant", "description": "" }, { "id": "MONDO:0700090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700090", "name": "epilepsy, partial, with auditory features", "description": "" }, { "id": "MIM:600512", "resource": "MIM", "url": "https://www.omim.org/entry/600512", "name": "Epilepsy, familial temporal lobe, 1", "description": "Epilepsy, familial temporal lobe, 1" } ], "unlinked_id_list": [], "evidence": [ { "id": "3328", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3328" } ] }, { "disease_id": "DOID:7725", "recommended_name": { "id": "DOID:7725", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:7725", "name": "epilepsy with generalized tonic-clonic seizures", "description": "An adolescence-adult electroclinical syndrome starting in adolescence exhibiting generalized tonic-clonic seizures as the only seizure type." }, "synonyms": [ { "id": "DOID:7725", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:7725", "name": "Epileptic seizures, tonic-clonic", "description": "" }, { "id": "DOID:7725", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:7725", "name": "Grand Mal epilepsy", "description": "" }, { "id": "DOID:7725", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:7725", "name": "tonic-clonic epilepsy", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "7725", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:7725" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "60.77", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000158486", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158486" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "63.95", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000158486", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158486" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "60.69", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000158486", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158486" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "92.05", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000158486", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158486" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "56.4", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000158486", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158486" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "74.79", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000158486", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158486" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "72.96", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000158486", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158486" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "55.58", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000158486", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158486" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "46.98", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000158486", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158486" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "70.93", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000158486", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158486" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "48.41", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000158486", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158486" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "47.52", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000158486", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158486" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "49.94", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000158486", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158486" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "Q8TD57", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q8TD57" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "Q8TD57", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q8TD57" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "Q8TD57", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q8TD57" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": 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"MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant 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"Other" ] }, { "id": "1340694", "url": "https://www.iedb.org/epitope/1340694", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1345039", "url": "https://www.iedb.org/epitope/1345039", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1345542", "url": "https://www.iedb.org/epitope/1345542", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1357706", "url": "https://www.iedb.org/epitope/1357706", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1359921", "url": "https://www.iedb.org/epitope/1359921", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1376084", "url": "https://www.iedb.org/epitope/1376084", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1713705", "url": "https://www.iedb.org/epitope/1713705", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1870599", "url": "https://www.iedb.org/epitope/1870599", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1912408", "url": "https://www.iedb.org/epitope/1912408", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1913541", "url": "https://www.iedb.org/epitope/1913541", "database": "IEDB", "categories": [ "Other" ] }, { "id": "194203", "url": "https://www.iedb.org/epitope/194203", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1983118", "url": "https://www.iedb.org/epitope/1983118", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2003484", "url": "https://www.iedb.org/epitope/2003484", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2003537", "url": "https://www.iedb.org/epitope/2003537", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2009425", "url": "https://www.iedb.org/epitope/2009425", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2013309", "url": "https://www.iedb.org/epitope/2013309", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2020764", "url": "https://www.iedb.org/epitope/2020764", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2021265", "url": "https://www.iedb.org/epitope/2021265", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2030801", "url": "https://www.iedb.org/epitope/2030801", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2031333", "url": "https://www.iedb.org/epitope/2031333", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2037230", "url": "https://www.iedb.org/epitope/2037230", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2037252", "url": "https://www.iedb.org/epitope/2037252", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2040857", "url": "https://www.iedb.org/epitope/2040857", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2041343", "url": "https://www.iedb.org/epitope/2041343", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2043117", "url": "https://www.iedb.org/epitope/2043117", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2047442", "url": "https://www.iedb.org/epitope/2047442", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2048642", "url": "https://www.iedb.org/epitope/2048642", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2052161", "url": "https://www.iedb.org/epitope/2052161", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2055099", "url": "https://www.iedb.org/epitope/2055099", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2056985", "url": "https://www.iedb.org/epitope/2056985", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2060311", "url": "https://www.iedb.org/epitope/2060311", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2060331", "url": "https://www.iedb.org/epitope/2060331", "database": "IEDB", "categories": [ "Other" ] }, { "id": "213080", "url": "https://www.iedb.org/epitope/213080", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2141965", "url": "https://www.iedb.org/epitope/2141965", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2218506", "url": "https://www.iedb.org/epitope/2218506", "database": "IEDB", "categories": [ "Other" ] }, { "id": "424244", "url": "https://www.iedb.org/epitope/424244", "database": "IEDB", "categories": [ "Other" ] }, { "id": "505995", "url": "https://www.iedb.org/epitope/505995", "database": "IEDB", "categories": [ "Other" ] }, { "id": "625585", "url": "https://www.iedb.org/epitope/625585", "database": "IEDB", "categories": [ "Other" ] }, { "id": "717098", "url": "https://www.iedb.org/epitope/717098", "database": "IEDB", "categories": [ "Other" ] }, { "id": "924877", "url": "https://www.iedb.org/epitope/924877", "database": "IEDB", "categories": [ "Other" ] }, { "id": "Q8TD57", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q8TD57*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004273", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004273", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013602", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013602", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024317", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024317", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024743", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024743", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035699", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035699", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035706", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035706", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041228", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041228", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041466", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041466", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041589", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041589", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041658", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041658", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042219", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042219", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042222", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042222", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042228", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042228", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043157", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043157", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:55567", "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:55567", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "603334", "url": "http://www.omim.org/entry/603334", "database": "MIM", "categories": [ "Other" ] }, { "id": "Q8TD57", "url": "https://oglcnac.org/atlas/detail/Q8TD57", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "KIWRRIM", "url": "https://omabrowser.org/oma/group/KIWRRIM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A8I5KSE2", "url": "https://www.orthodb.org/?gene=A0A8I5KSE2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A8V8TLI9", "url": "https://www.orthodb.org/?gene=A0A8V8TLI9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q8TD57", "url": "https://www.orthodb.org/?gene=Q8TD57", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22878", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22878", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22878:SF71", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22878:SF71", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00008j07", "url": "https://www.rcsb.org/structure/pdb_00008j07", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8J07", "url": "https://www.rcsb.org/structure/8J07", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF03028", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03028", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF08393", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08393", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF12774", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12774", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF12775", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12775", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF12777", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12777", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF12780", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12780", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF12781", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12781", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF17852", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17852", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF17857", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17857", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF18198", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18198", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF18199", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18199", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "Q8TD57", "url": "https://pharos.nih.gov/targets/Q8TD57", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR:Q8TD57", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:Q8TD57", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001334815", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334815", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A8I5KSE2", "url": "https://www.uniprot.org/uniprotkb/A0A8I5KSE2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5KSE2-1", "url": "https://www.uniprot.org/uniprotkb/A0A8I5KSE2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V8TLI9", "url": "https://www.uniprot.org/uniprotkb/A0A8V8TLI9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V8TLI9-1", "url": "https://www.uniprot.org/uniprotkb/A0A8V8TLI9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8TD57", "url": "https://www.uniprot.org/uniprotkb/Q8TD57", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8TD57-1", "url": "https://www.uniprot.org/uniprotkb/Q8TD57-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8TD57-2", "url": "https://www.uniprot.org/uniprotkb/Q8TD57-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8TD57-3", "url": "https://www.uniprot.org/uniprotkb/Q8TD57-3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGATGRLELTLAAPPHPGPAFQRSKARETQGEEEGSEMQIAKSDSIHHMSHSQGQPELPPLPASANEEPSGLYQTVMSHSFYPPLMQRTSWTLAAPFKEQHHHRGPSDSIANNYSLMAQDLKLKDLLKVYQPATISVPRDRTGQGLPSSGNRSSSEPMRKKTKFSSRNKEDSTRIKLAFKTSIFSPMKKEVKTSLTFPGSRPMSPEQQLDVMLQQEMEMESKEKKPSESDLERYYYYLTNGIRKDMIAPEEGEVMVRISKLISNTLLTSPFLEPLMVVLVQEKENDYYCSLMKSIVDYILMDPMERKRLFIESIPRLFPQRVIRAPVPWHSVYRSAKKWNEEHLHTVNPMMLRLKELWFAEFRDLRFVRTAEILAGKLPLQPQEFWDVIQKHCLEAHQTLLNKWIPTCAQLFTSRKEHWIHFAPKSNYDSSRNIEEYFASVASFMSLQLRELVIKSLEDLVSLFMIHKDGNDFKEPYQEMKFFIPQLIMIKLEVSEPIIVFNPSFDGCWELIRDSFLEIIKNSNGIPKLKYIPLKFSFTAAAADRQCVKAAEPGEPSMHAAATAMAELKGYNLLLGTVNAEEKLVSDFLIQTFKVFQKNQVGPCKYLNVYKKYVDLLDNTAEQNIAAFLKENHDIDDFVTKINAIKKRRNEIASMNITVPLAMFCLDATALNHDLCERAQNLKDHLIQFQVDVNRDTNTSICNQYSHIADKVSEVPANTKELVSLIEFLKKSSAVTVFKLRRQLRDASERLEFLMDYADLPYQIEDIFDNSRNLLLHKRDQAEMDLIKRCSEFELRLEGYHRELESFRKREVMTTEEMKHNVEKLNELSKNLNRAFAEFELINKEEELLEKEKSTYPLLQAMLKNKVPYEQLWSTAYEFSIKSEEWMNGPLFLLNAEQIAEEIGNMWRTTYKLIKTLSDVPAPRRLAENVKIKIDKFKQYIPILSISCNPGMKDRHWQQISEIVGYEIKPTETTCLSNMLEFGFGKFVEKLEPIGAAASKEYSLEKNLDRMKLDWVNVTFSFVKYRDTDTNILCAIDDIQMLLDDHVIKTQTMCGSPFIKPIEAECRKWEEKLIRIQDNLDAWLKCQATWLYLEPIFSSEDIIAQMPEEGRKFGIVDSYWKSLMSQAVKDNRILVAADQPRMAEKLQEANFLLEDIQKGLNDYLEKKRLFFPRFFFLSNDELLEILSETKDPLRVQPHLKKCFEGIAKLEFTDNLEIVGMISSEKETVPFIQKIYPANAKGMVEKWLQQVEQMMLASMREVIGLGIEAYVKVPRNHWVLQWPGQVVICVSSIFWTQEVSQALAENTLLDFLKKSNDQIAQIVQLVRGKLSSGARLTLGALTVIDVHARDVVAKLSEDRVSDLNDFQWISQLRYYWVAKDVQVQIITTEALYGYEYLGNSPRLVITPLTDRCYRTLMGALKLNLGGAPEGPAGTGKTETTKDLAKALAKQCVVFNCSDGLDYKAMGKFFKGLAQAGAWACFDEFNRIEVEVLSVVAQQILSIQQAIIRKLKTFIFEGTELSLNPTCAVFITMNPGYAGRAELPDNLKALFRTVAMMVPDYALIGEISLYSMGFLDSRSLAQKIVATYRLCSEQLSSQHHYDYGMRAVKSVLTAAGNLKLKYPEENESVLLLRALLDVNLAKFLAQDVPLFQGIISDLFPGVVLPKPDYEVFLKVLNDNIKKMKLQPVPWFIGKIIQIYEMMLVRHGYMIVGDPMGGKTSAYKVLAAALGDLHAANQMEEFAVEYKIINPKAITMGQLYGCFDQVSHEWMDGVLANAFREQASSLSDDRKWIIFDGPVDAIWIENMNTVLDDNKKLCLMSGEIIQMNSKMSLIFEPADLEQASPATVSRCGMIYMEPHQLGWKPLKDSYMDTLPSSLTKEHKELVNDMFMWLVQPCLEFGRLHCKFVVQTSPIHLAFSMMRLYSSLLDEIRAVEEEEMELGEGLSSQQIFLWLQGLFLFSLVWTVAGTINADSRKKFDVFFRNLIMGMDDNHPRPKSVKLTKNNIFPERGSIYDFYFIKQASGHWETWTQYITKEEEKVPAGAKVSELIIPTMETARQSFFLKTYLDHEIPMLFVGPTGTGKSAITNNFLLHLPKNTYLPNCINFSARTSANQTQDIIMSKLDRRRKGLFGPPIGKKAVVFVDDLNMPAKEVYGAQPPIELLRQWIDHGYWFDKKDTTRLDIVDMLLVTAMGPPGGGRNDITGRFTRHLNIISINAFEDDILTKIFSSIVDWHFGKGFDVMFLRYGKMLVQATKTIYRDAVENFLPTPSKSHYVFNLRDFSRVIQGVLLCPHTHLQDVEKCIRLWIHEVYRVFYDRLIDKEDRQVFFNMVKETTSNCFKQTIEKVLIHLSPTGKIVDDNIRSLFFGDYFKPESDQKIYDEITDLKQLTVVMEHYLEEFNNISKAPMSLVMFRFAIEHISRICRVLKQDKGHLLLVGIGGSGRQSAAKLSTFMNAYELYQIEITKNYAGNDWREDLKKIILQVGVATKSTVFLFADNQIKDESFVEDINMLLNTGDVPNIFPADEKADIVEKMQTAARTQGEKVEVTPLSMYNFFIERVINKISFSLAMSPIGDAFRNRLRMFPSLINCCTIDWFQSWPTDALELVANKFLEDVELDDNIRVEVVSMCKYFQESVKKLSLDYYNKLRRHNYVTPTSYLELILTFKTLLNSKRQEVAMMRNRYLTGLQKLDFAASQVAVMQRELTALQPQLILTSEETAKMMVKIEAETREADGKKLLVQADEKEANVAAAIAQGIKNECEGDLAEAMPALEAALAALDTLNPADISLVKSMQNPPGPVKLVMESICIMKGMKPERKPDPSGSGKMIEDYWGVSKKILGDLKFLESLKTYDKDNIPPLTMKRIRERFINHPEFQPAVIKNVSSACEGLCKWVRAMEVYDRVAKVVAPKRERLREAEGKLAAQMQKLNQKRAELKLVVDRLQALNDDFEEMNTKKKDLEENIEICSQKLVRAEKLISGLGGEKDRWTEAARQLGIRYTNLTGDVLLSSGTVAYLGAFTVDYRVQCQNQWLAECKDKVIPGFSDFSLSHTLGDPIKIRAWQIAGLPVDSFSIDNGIIVSNSRRWALMIDPHGQANKWIKNMEKANKLAVIKFSDSNYMRMLENALQLGTPVLIENIGEELDASIEPILLKATFKQQGVEYMRLGENIIEYSRDFKLYITTRLRNPHYLPEVAVKVCLLNFMITPLGLQDQLLGIVAAKEKPELEEKKNQLIVESAKNKKHLKEIEDKILEVLSMSKGNILEDETAIKVLSSSKVLSEEISEKQKVASMTETQIDETRMGYKPVAVHSATIFFCISDLANIEPMYQYSLTWFINLYMHSLTHSTKSEELNLRIKYIIDHFTLSIYNNVCRSLFEKDKLLFSLLLTIGIMKQKKEITEEVWYFLLTGGIALDNPYPNPAPQWLSEKAWAEIVRASALPKLHGLMEHLEQNLGEWKLIYDSAWPHEEQLPGSWKFSQGLEKMVILRCLRPDKMVPAVREFIAEHMGKLYIEAPTFDLQGSYNDSSCCAPLIFVLSPSADPMAGLLKFADDLGMGGTRTQTISLGQGQGPIAAKMINNAIKDGTWVVLQNCHLAASWMPTLEKICEEVIVPESTNARFRLWLTSYPSEKFPVSILQNGIKMTNEPPKGLRANLLRSYLNDPISDPVFFQSCAKAVMWQKMLFGLCFFHAVVQERRNFGPLGWNIPYEFNESDLRISMWQIQMFLNDYKEVPFDALTYLTGECNYGGRVTDDKDRRLLLSLLSMFYCKEIEEDYYSLAPGDTYYIPPHGSYQSYIDYLRNLPITAHPEVFGLHENADITKDNQETNQLFEGVLLTLPRQSGGSGKSPQEVVEELAQDILSKLPRDFDLEEVMKLYPVVYEESMNTVLRQELIRFNRLTKVVRRSLINLGRAIKGQVLMSSELEEVFNSMLVGKVPAMWAAKSYPSLKPLGGYVADLLARLTFFQEWIDKGPPVVFWISGFYFTQSFLTGVSQNYARKYTIPIDHIGFEFEVTPQETVMENNPEDGAYIKGLFLEGARWDRKTMQIGESLPKILYDPLPIIWLKPGESAMFLHQDIYVCPVYKTSARRGTLSTTGHSTNYVLSIELPTDMPQKHWINRGVASLCQLDN", "length": 4116, "header": "sp|Q8TD57-1|DYH3_HUMAN Isoform 1 of Dynein axonemal heavy chain 3 OS=Homo sapiens OX=9606 GN=DNAH3 PE=1 SV=1 CANONICAL=Q8TD57-1" }, "isoforms": [ { "isoform_ac": "A0A8I5KSE2-1", "url": "https://www.uniprot.org/uniprotkb/Q8TD57/entry#A0A8I5KSE2-1", "sequence": { "sequence": "MGATGRLELTLAAPPHPGPAFQRSKARETQGEEEGSEMQIAKSDSIHHMSHSQGQPELPPLPASANEEPSGLYQTVMSHSFYPPLMQRTSWTLAAPFKEQHHHRGPSDSIANNYSLMAQDLKLKDLLKVYQPATISVPRDRTGQGLPSSGNRSSSEPMRKKTKFSSRNKEDSTRIKLAFKTSIFSPMKKEVKTSLTFPGSRPMSPEQQLDVMLQQEMEMESKEKKPSESDLERYYYYLTNGIRKDMIAPEEGEVMVRISKLISNTLLTSPFLEPLMVVLVQEKENDYYCSLMKSIVDYILMDPMERKRLFIESIPRLFPQRVIRAPVPWHSVYRSAKKWNEEHLHTVNPMMLRLKELWFAEFRDLRFVRTAEILAGKLPLQPQEFWDVIQKHCLEAHQTLLNKWIPTCAQLFTSRKEHWIHFAPKSNYDSSRNIEEYFASVASFMSLQLRELVIKSLEDLVSLFMIHKDGNDFKEPYQEMKFFIPQLIMIKLEVSEPIIVFNPSFDGCWELIRDSFLEIIKNSNGIPKLKYIPLKFSFTAAAADRQCVKAAEPGEPSMHAAATAMAELKGYNLLLGTVNAEEKLVSDFLIQTFKVFQKNQVGPCKYLNVYKKYVDLLDNTAEQNIAAFLKENHDIDDFVTKINAIKKRRNEIASMNITVPLAMFCLDATALNHDLCERAQNLKDHLIQFQVDVNRDTNTSICNQYSHIADKVSEVPANTKELVSLIEFLKKSSAVTVFKLRRQLRDASERLEFLMDYADLPYEDIKLNSTLFLWPDQIEDIFDNSRNLLLHKRDQAEMDLIKRCSEFELRLEGYHRELESFRKREVMTTEEMKHNVEKLNELSKNLNRAFAEFELINKEEELLEKEKSTYPLLQAMLKNKVPYEQLWSTAYEFSIKSEEWMNGPLFLLNAEQIAEEIGNMWRTTYKLIKTLSDVPAPRRLAENVKIKIDKFKQYIPILSISCNPGMKDRHWQQISEIVGYEIKPTETTCLSNMLEFGFGKFVEKLEPIGAAASKEYSLEKNLDRMKLDWVNVTFSFVKYRDTDTNILCAIDDIQMLLDDHVIKTQTMCGSPFIKPIEAECRKWEEKLIRIQDNLDAWLKCQATWLYLEPIFSSEDIIAQMPEEGRKFGIVDSYWKSLMSQAVKDNRILVAADQPRMAEKLQEANFLLEDIQKGLNDYLEKKRLFFPRFFFLSNDELLEILSETKDPLRVQPHLKKCFEGIAKLEFTDNLEIVGMISSEKETVPFIQKIYPANAKGMVEKWLQQVEQMMLASMREVIGLGIEAYVKVPRNHWVLQWPGQVVICVSSIFWTQEVSQALAENTLLDFLKKSNDQIAQIVQLVRGKLSSGARLTLGALTVIDVHARDVVAKLSEDRVSDLNDFQWISQLRYYWVAKDVQVQIITTEALYGYEYLGNSPRLVITPLTDRCYRTLMGALKLNLGGAPEGPAGTGKTETTKDLAKALAKQCVVFNCSDGLDYKAMGKFFKGLAQAGAWACFDEFNRIEVEVLSVVAQQILSIQQAIIRKLKTFIFEGTELSLNPTCAVFITMNPGYAGRAELPDNLKALFRTVAMMVPDYALIGEISLYSMGFLDSRSLAQKIVATYRLCSEQLSSQHHYDYGMRAVKSVLTAAGNLKLKYPEENESVLLLRALLDVNLAKFLAQDVPLFQGIISDLFPGVVLPKPDYEVFLKVLNDNIKKMKLQPVPWFIGKIIQIYEMMLVRHGYMIVGDPMGGKTSAYKVLAAALGDLHAANQMEEFAVEYKIINPKAITMGQLYGCFDQVSHEWMDGVLANAFREQASSLSDDRKWIIFDGPVDAIWIENMNTVLDDNKKLCLMSGEIIQMNSKMSLIFEPADLEQASPATVSRCGMIYMEPHQLGWKPLKDSYMDTLPSSLTKEHKELVNDMFMWLVQPCLEFGRLHCKFVVQTSPIHLAFSMMRLYSSLLDEIRAVEEEEMELGEGLSSQQIFLWLQGLFLFSLVWTVAGTINADSRKKFDVFFRNLIMGMDDNHPRPKSVKLTKNNIFPERGSIYDFYFIKQASGHWETWTQYITKEEEKVPAGAKVSELIIPTMETARQSFFLKTYLDHEIPMLFVGPTGTGKSAITNNFLLHLPKNTYLPNCINFSARTSANQTQDIIMSKLDRRRKGLFGPPIGKKAVVFVDDLNMPAKEVYGAQPPIELLRQWIDHGYWFDKKDTTRLDIVDMLLVTAMGPPGGGRNDITGRFTRHLNIISINAFEDDILTKIFSSIVDWHFGKGFDVMFLRYGKMLVQATKTIYRDAVENFLPTPSKSHYVFNLRDFSRVIQGVLLCPHTHLQDVEKCIRLWIHEVYRVFYDRLIDKEDRQVFFNMVKETTSNCFKQTIEKVLIHLSPTGKIVDDNIRSLFFGDYFKPESDQKIYDEITDLKQLTVVMEHYLEEFNNISKAPMSLVMFRFAIEHISRICRVLKQDKGHLLLVGIGGSGRQSAAKLSTFMNAYELYQIEITKNYAGNDWREDLKKIILQVGVATKSTVFLFADNQIKDESFVEDINMLLNTGDVPNIFPADEKADIVEKMQTAARTQGEKVEVTPLSMYNFFIERVINKISFSLAMSPIGDAFRNRLRMFPSLINCCTIDWFQSWPTDALELVANKFLEDVELDDNIRVEVVSMCKYFQESVKKLSLDYYNKLRRHNYVTPTSYLELILTFKTLLNSKRQEVAMMRNRYLTGLQKLDFAASQVAVMQRELTALQPQLILTSEETAKMMVKIEAETREADGKKLLVQADEKEANVAAAIAQGIKNECEGDLAEAMPALEAALAALDTLNPADISLVKSMQNPPGPVKLVMESICIMKGMKPERKPDPSGSGKMIEDYWGVSKKILGDLKFLESLKTYDKDNIPPLTMKRIRERFINHPEFQPAVIKNVSSACEGLCKWVRAMEVYDRVAKVVAPKRERLREAEGKLAAQMQKLNQKRAELKLVVDRLQALNDDFEEMNTKKKDLEENIEICSQKLVRAEKLISGLGGEKDRWTEAARQLGIRYTNLTGDVLLSSGTVAYLGAFTVDYRVQCQNQWLAECKDKVIPGFSDFSLSHTLGDPIKIRAWQIAGLPVDSFSIDNGIIVSNSRRWALMIDPHGQANKWIKNMEKANKLAVIKFSDSNYMRMLENALQLGTPVLIENIGEELDASIEPILLKATFKQQGVEYMRLGENIIEYSRDFKLYITTRLRNPHYLPEVAVKVCLLNFMITPLGLQDQLLGIVAAKEKPELEEKKNQLIVESAKNKKHLKEIEDKILEVLSMSKGNILEDETAIKVLSSSKVLSEEISEKQKVASMTETQIDETRMGYKPVAVHSATIFFCISDLANIEPMYQYSLTWFINLYMHSLTHSTKSEELNLRIKYIIDHFTLSIYNNVCRSLFEKDKLLFSLLLTIGIMKQKKEITEEVWYFLLTGGIALDNPYPNPAPQWLSEKAWAEIVRASALPKLHGLMEHLEQNLGEWKLIYDSAWPHEEQLPGSWKFSQGLEKMVILRCLRPDKMVPAVREFIAEHMGKLYIEAPTFDLQGSYNDSSCCAPLIFVLSPSADPMAGLLKFADDLGMGGTRTQTISLGQGQGPIAAKMINNAIKDGTWVVLQNCHLAASWMPTLEKICEEVIVPESTNARFRLWLTSYPSEKFPVSILQNGIKMTNEPPKGLRANLLRSYLNDPISDPVFFQSCAKAVMWQKMLFGLCFFHAVVQERRNFGPLGWNIPYEFNESDLRISMWQIQMFLNDYKEVPFDALTYLTGECNYGGRVTDDKDRRLLLSLLSMFYCKEIEEDYYSLAPGDTYYIPPHGSYQSYIDYLRNLPITAHPEVFGLHENADITKDNQETNQLFEGVLLTLPRQSGGSGKSPQEVVEELAQDILSKLPRDFDLEEVMKLYPVVYEESMNTVLRQELIRFNRLTKVVRRSLINLGRAIKGQVLMSSELEEVFNSMLVGKVPAMWAAKSYPSLKPLGGYVADLLARLTFFQEWIDKGPPVVFWISGFYFTQSFLTGVSQNYARKYTIPIDHIGFEFEVTPQETVMENNPEDGAYIKGLFLEGARWDRKTMQIGESLPKILYDPLPIIWLKPGESAMFLHQDIYVCPVYKTSARRGTLSTTGHSTNYVLSIELPTDMPQKHWINRGVASLCQLDN", "length": 4130, "header": "tr|A0A8I5KSE2-1|A0A8I5KSE2_HUMAN Computationally mapped isoform of Dynein axonemal heavy chain 3 OS=Homo sapiens OX=9606 GN=DNAH3 PE=1 SV=1 CANONICAL=Q8TD57-1" }, "locus": { "chromosome": "16", "start_pos": 21159441, "end_pos": 20933157, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000685858.1", "url": "https://www.ensembl.org/id/ENST00000685858.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000508756.1", "url": "https://www.ensembl.org/id/ENSP00000508756.1" } ] } }, { "isoform_ac": "A0A8V8TLI9-1", "url": "https://www.uniprot.org/uniprotkb/Q8TD57/entry#A0A8V8TLI9-1", "sequence": { "sequence": "MGDMDCSSQKIAKSDSIHHMSHSQGQPELPPLPASANEEPSGLYQTVMSHSFYPPLMQRTSWTLAAPFKEQHHHRGPSDSIANNYSLMAQDLKLKDLLKVYQPATISVPRDRTGQGLPSSGNRSSSEPMRKKTKFSSRNKEDSTRIKLAFKTSIFSPMKKEVKTSLTFPGSRPMSPEQQLDVMLQQEMEMESKEKKPSESDLERYYYYLTNGIRKDMIAPEEGEVMVRISKLISNTLLTSPFLEPLMVVLVQEKENDYYCSLMKSIVDYILMDPMERKRLFIESIPRLFPQRVIRAPVPWHSVYRSAKKWNEEHLHTVNPMMLRLKELWFAEFRDLRFVRTAEILAGKLPLQPQEFWDVIQKHCLEAHQTLLNKWIPTCAQLFTSRKEHWIHFAPKSNYDSSRNIEEYFASVASFMSLQLRELVIKSLEDLVSLFMIHKDGNDFKEPYQEMKFFIPQLIMIKLEVSEPIIVFNPSFDGCWELIRDSFLEIIKNSNGIPKVESVLFPELKGYNLLLGTVNAEEKLVSDFLIQTFKVFQKNQVGPCKYLNVYKKYVDLLDNTAEQNIAAFLKENHDIDDFVTKINAIKKRRNEIASMNITVPLAMFCLDATALNHDLCERAQNLKDHLIQFQVDVNRDTNTSICNQYSHIADKVSEVPANTKELVSLIEFLKKSSAVTVFKLRRQLRDASERLEFLMDYADLPYEDIKLNSTLFLWPDQIEDIFDNSRNLLLHKRDQAEMDLIKRCSEFELRLEGYHRELESFRKREVMTTEEMKHNVEKLNELSKNLNRAFAEFELINKEEELLEKEKSTYPLLQAMLKNKVPYEQLWSTAYEFSIKSEEWMNGPLFLLNAEQIAEEIGNMWRTTYKLIKTLSDVPAPRRLAENVKIKIDKFKQYIPILSISCNPGMKDRHWQQISEIVGYEIKPTETTCLSNMLEFGFGKFVEKLEPIGAAASKEYSLEKNLDRMKLDWVNVTFSFVKYRDTDTNILCAIDDIQMLLDDHVIKTQTMCGSPFIKPIEAECRKWEEKLIRIQDNLDAWLKCQATWLYLEPIFSSEDIIAQMPEEGRKFGIVDSYWKSLMSQAVKDNRILVAADQPRMAEKLQEANFLLEDIQKGLNDYLEKKRLFFPRFFFLSNDELLEILSETKDPLRVQPHLKKCFEGIAKLEFTDNLEIVGMISSEKETVPFIQKIYPANAKGMVEKWLQQVEQMMLASMREVIGLGIEAYVKVPRNHWVLQWPGQVVICVSSIFWTQEVSQALAENTLLDFLKKSNDQIAQIVQLVRGKLSSGARLTLGALTVIDVHARDVVAKLSEDRVSDLNDFQWISQLRYYWVAKDVQVQIITTEALYGYEYLGNSPRLVITPLTDRCYRTLMGALKLNLGGAPEGPAGTGKTETTKDLAKALAKQCVVFNCSDGLDYKAMGKFFKGLAQAGAWACFDEFNRIEVEVLSVVAQQILSIQQAIIRKLKTFIFEGTELSLNPTCAVFITMNPGYAGRAELPDNLKALFRTVAMMVPDYALIGEISLYSMGFLDSRSLAQKIVATYRLCSEQLSSQHHYDYGMRAVKSVLTAAGNLKLKYPEENESVLLLRALLDVNLAKFLAQDVPLFQGIISDLFPGVVLPKPDYEVFLKVLNDNIKKMKLQPVPWFIGKIIQIYEMMLVRHGYMIVGDPMGGKTSAYKVLAAALGDLHAANQMEEFAVEYKIINPKAITMGQLYGCFDQVSHEWMDGVLANAFREQASSLSDDRKWIIFDGPVDAIWIENMNTVLDDNKKLCLMSGEIIQMNSKMSLIFEPADLEQASPATVSRCGMIYMEPHQLGWKPLKDSYMDTLPSSLTKEHKELVNDMFMWLVQPCLEFGRLHCKFVVQTSPIHLAFSMMRLYSSLLDEIRAVEEEEMELGEGLSSQQIFLWLQGLFLFSLVWTVAGTINADSRKKFDVFFRNLIMGMDDNHPRPKSVKLTKNNIFPERGSIYDFYFIKQASGHWETWTQYITKEEEKVPAGAKVSELIIPTMETARQSFFLKTYLDHEIPMLFVGPTGTGKSAITNNFLLHLPKNTYLPNCINFSARTSANQTQDIIMSKLDRRRKGLFGPPIGKKAVVFVDDLNMPAKEVYGAQPPIELLRQWIDHGYWFDKKDTTRLDIVDMLLVTAMGPPGGGRNDITGRFTRHLNIISINAFEDDILTKIFSSIVDWHFGKGFDVMFLRYGKMLVQATKTIYRDAVENFLPTPSKSHYVFNLRDFSRVIQGVLLCPHTHLQDVEKCIRLWIHEVYRVFYDRLIDKEDRQVFFNMVKETTSNCFKQTIEKVLIHLSPTGKIVDDNIRSLFFGDYFKPESDQKIYDEITDLKQLTVVMEHYLEEFNNISKAPMSLVMFRFAIEHISRICRVLKQDKGHLLLVGIGGSGRQSAAKLSTFMNAYELYQIEITKNYAGNDWREDLKKIILQVGVATKSTVFLFADNQIKDESFVEDINMLLNTGDVPNIFPADEKADIVEKMQTAARTQGEKVEVTPLSMYNFFIERVRKNLHIVLAMSPIGDAFRNRLRMFPSLINCCTIDWFQSWPTDALELVANKFLEDVELDDNIRVEVVSMCKYFQESVKKLSLDYYNKLRRHNYVTPTSYLELILTFKTLLNSKRQEVAMMRNRYLTGLQKLDFAASQVAVMQRELTALQPQLILTSEETAKMMVKIEAETREADGKKLLVQADEKEANVAAAIAQGIKNECEGDLAEAMPALEAALAALDTLNPADISLVKSMQNPPGPVKLVMESICIMKGMKPERKPDPSGSGKMIEDYWGVSKKILGDLKFLESLKTYDKDNIPPLTMKRIRERFINHPEFQPAVIKNVSSACEGLCKWVRAMEVYDRVAKVVAPKRERLREAEGKLAAQMQKLNQKRAELKLVVDRLQALNDDFEEMNTKKKDLEENIEICSQKLVRAEKLISGLGGEKDRWTEAARQLGIRYTNLTGDVLLSSGTVAYLGAFTVDYRVQCQNQWLAECKDKVIPGFSDFSLSHTLGDPIKIRAWQIAGLPVDSFSIDNGIIVSNSRRWALMIDPHGQANKWIKNMEKANKLAVIKFSDSNYMRMLENALQLGTPVLIENIGEELDASIEPILLKATFKQQGVEYMRLGENIIEYSRDFKLYITTRLRNPHYLPEVAVKVCLLNFMITPLGLQDQLLGIVAAKEKPELEEKKNQLIVESAKNKKHLKEIEDKILEVLSMSKGNILEDETAIKVLSSSKVLSEEISEKQKVASMTETQIDETRMGYKPVAVHSATIFFCISDLANIEPMYQYSLTWFINLYMHSLTHSTKSEELNLRIKYIIDHFTLSIYNNVCRSLFEKDKLLFSLLLTIGIMKQKKEITEEVWYFLLTGGIALDNPYPNPAPQWLSEKAWAEIVRASALPKLHGLMEHLEQNLGEWKLIYDSAWPHEEQLPGSWKFSQGLEKMVILRCLRPDKMVPAVREFIAEHMGKLYIEAPTFDLQGSYNDSSCCAPLIFVLSPSADPMAGLLKFADDLGMGGTRTQTISLGQGQGPIAAKMINNAIKDGTWVVLQNCHLAASWMPTLEKICEEVIVPESTNARFRLWLTSYPSEKFPVSILQNGIKMTNEPPKGLRANLLRSYLNDPISDPVFFQSCAKAVMWQKMLFGLCFFHAVVQERRNFGPLGWNIPYEFNESDLRISMWQIQMFLNDYKEVPFDALTYLTGECNYGGRVTDDKDRRLLLSLLSMFYCKEIEEDYYSLAPGDTYYIPPHGSYQSYIDYLRNLPITAHPEVFGLHENADITKDNQETNQLFEGVLLTLPRQSGGSGKSPQEVVEELAQDILSKLPRDFDLEEVMKLYPVVYEESMNTVLRQELIRFNRLTKVVRRSLINLGRAIKGQVLMSSELEEVFNSMLVGKVPAMWAAKSYPSLKPLGGYVADLLARLTFFQEWIDKGPPVVFWISGFYFTQSFLTGVSQNYARKYTIPIDHIGFEFEVTPQETVMENNPEDGAYIKGLFLEGARWDRKTMQIGESLPKILYDPLPIIWLKPGESAMFLHQDIYVCPVYKTSARRGTLSTTGHSTNYVLSIELPTDMPQKHWINRGVASLCQLDN", "length": 4070, "header": "tr|A0A8V8TLI9-1|A0A8V8TLI9_HUMAN Computationally mapped isoform of Dynein axonemal heavy chain 3 OS=Homo sapiens OX=9606 GN=DNAH3 PE=1 SV=1 CANONICAL=Q8TD57-1" }, "locus": { "chromosome": "16", "start_pos": 21150319, "end_pos": 20933157, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000698260.1", "url": "https://www.ensembl.org/id/ENST00000698260.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000513632.1", "url": "https://www.ensembl.org/id/ENSP00000513632.1" } ] } }, { "isoform_ac": "Q8TD57-1", "url": "https://www.uniprot.org/uniprotkb/Q8TD57/entry#Q8TD57-1", "sequence": { "sequence": "MGATGRLELTLAAPPHPGPAFQRSKARETQGEEEGSEMQIAKSDSIHHMSHSQGQPELPPLPASANEEPSGLYQTVMSHSFYPPLMQRTSWTLAAPFKEQHHHRGPSDSIANNYSLMAQDLKLKDLLKVYQPATISVPRDRTGQGLPSSGNRSSSEPMRKKTKFSSRNKEDSTRIKLAFKTSIFSPMKKEVKTSLTFPGSRPMSPEQQLDVMLQQEMEMESKEKKPSESDLERYYYYLTNGIRKDMIAPEEGEVMVRISKLISNTLLTSPFLEPLMVVLVQEKENDYYCSLMKSIVDYILMDPMERKRLFIESIPRLFPQRVIRAPVPWHSVYRSAKKWNEEHLHTVNPMMLRLKELWFAEFRDLRFVRTAEILAGKLPLQPQEFWDVIQKHCLEAHQTLLNKWIPTCAQLFTSRKEHWIHFAPKSNYDSSRNIEEYFASVASFMSLQLRELVIKSLEDLVSLFMIHKDGNDFKEPYQEMKFFIPQLIMIKLEVSEPIIVFNPSFDGCWELIRDSFLEIIKNSNGIPKLKYIPLKFSFTAAAADRQCVKAAEPGEPSMHAAATAMAELKGYNLLLGTVNAEEKLVSDFLIQTFKVFQKNQVGPCKYLNVYKKYVDLLDNTAEQNIAAFLKENHDIDDFVTKINAIKKRRNEIASMNITVPLAMFCLDATALNHDLCERAQNLKDHLIQFQVDVNRDTNTSICNQYSHIADKVSEVPANTKELVSLIEFLKKSSAVTVFKLRRQLRDASERLEFLMDYADLPYQIEDIFDNSRNLLLHKRDQAEMDLIKRCSEFELRLEGYHRELESFRKREVMTTEEMKHNVEKLNELSKNLNRAFAEFELINKEEELLEKEKSTYPLLQAMLKNKVPYEQLWSTAYEFSIKSEEWMNGPLFLLNAEQIAEEIGNMWRTTYKLIKTLSDVPAPRRLAENVKIKIDKFKQYIPILSISCNPGMKDRHWQQISEIVGYEIKPTETTCLSNMLEFGFGKFVEKLEPIGAAASKEYSLEKNLDRMKLDWVNVTFSFVKYRDTDTNILCAIDDIQMLLDDHVIKTQTMCGSPFIKPIEAECRKWEEKLIRIQDNLDAWLKCQATWLYLEPIFSSEDIIAQMPEEGRKFGIVDSYWKSLMSQAVKDNRILVAADQPRMAEKLQEANFLLEDIQKGLNDYLEKKRLFFPRFFFLSNDELLEILSETKDPLRVQPHLKKCFEGIAKLEFTDNLEIVGMISSEKETVPFIQKIYPANAKGMVEKWLQQVEQMMLASMREVIGLGIEAYVKVPRNHWVLQWPGQVVICVSSIFWTQEVSQALAENTLLDFLKKSNDQIAQIVQLVRGKLSSGARLTLGALTVIDVHARDVVAKLSEDRVSDLNDFQWISQLRYYWVAKDVQVQIITTEALYGYEYLGNSPRLVITPLTDRCYRTLMGALKLNLGGAPEGPAGTGKTETTKDLAKALAKQCVVFNCSDGLDYKAMGKFFKGLAQAGAWACFDEFNRIEVEVLSVVAQQILSIQQAIIRKLKTFIFEGTELSLNPTCAVFITMNPGYAGRAELPDNLKALFRTVAMMVPDYALIGEISLYSMGFLDSRSLAQKIVATYRLCSEQLSSQHHYDYGMRAVKSVLTAAGNLKLKYPEENESVLLLRALLDVNLAKFLAQDVPLFQGIISDLFPGVVLPKPDYEVFLKVLNDNIKKMKLQPVPWFIGKIIQIYEMMLVRHGYMIVGDPMGGKTSAYKVLAAALGDLHAANQMEEFAVEYKIINPKAITMGQLYGCFDQVSHEWMDGVLANAFREQASSLSDDRKWIIFDGPVDAIWIENMNTVLDDNKKLCLMSGEIIQMNSKMSLIFEPADLEQASPATVSRCGMIYMEPHQLGWKPLKDSYMDTLPSSLTKEHKELVNDMFMWLVQPCLEFGRLHCKFVVQTSPIHLAFSMMRLYSSLLDEIRAVEEEEMELGEGLSSQQIFLWLQGLFLFSLVWTVAGTINADSRKKFDVFFRNLIMGMDDNHPRPKSVKLTKNNIFPERGSIYDFYFIKQASGHWETWTQYITKEEEKVPAGAKVSELIIPTMETARQSFFLKTYLDHEIPMLFVGPTGTGKSAITNNFLLHLPKNTYLPNCINFSARTSANQTQDIIMSKLDRRRKGLFGPPIGKKAVVFVDDLNMPAKEVYGAQPPIELLRQWIDHGYWFDKKDTTRLDIVDMLLVTAMGPPGGGRNDITGRFTRHLNIISINAFEDDILTKIFSSIVDWHFGKGFDVMFLRYGKMLVQATKTIYRDAVENFLPTPSKSHYVFNLRDFSRVIQGVLLCPHTHLQDVEKCIRLWIHEVYRVFYDRLIDKEDRQVFFNMVKETTSNCFKQTIEKVLIHLSPTGKIVDDNIRSLFFGDYFKPESDQKIYDEITDLKQLTVVMEHYLEEFNNISKAPMSLVMFRFAIEHISRICRVLKQDKGHLLLVGIGGSGRQSAAKLSTFMNAYELYQIEITKNYAGNDWREDLKKIILQVGVATKSTVFLFADNQIKDESFVEDINMLLNTGDVPNIFPADEKADIVEKMQTAARTQGEKVEVTPLSMYNFFIERVINKISFSLAMSPIGDAFRNRLRMFPSLINCCTIDWFQSWPTDALELVANKFLEDVELDDNIRVEVVSMCKYFQESVKKLSLDYYNKLRRHNYVTPTSYLELILTFKTLLNSKRQEVAMMRNRYLTGLQKLDFAASQVAVMQRELTALQPQLILTSEETAKMMVKIEAETREADGKKLLVQADEKEANVAAAIAQGIKNECEGDLAEAMPALEAALAALDTLNPADISLVKSMQNPPGPVKLVMESICIMKGMKPERKPDPSGSGKMIEDYWGVSKKILGDLKFLESLKTYDKDNIPPLTMKRIRERFINHPEFQPAVIKNVSSACEGLCKWVRAMEVYDRVAKVVAPKRERLREAEGKLAAQMQKLNQKRAELKLVVDRLQALNDDFEEMNTKKKDLEENIEICSQKLVRAEKLISGLGGEKDRWTEAARQLGIRYTNLTGDVLLSSGTVAYLGAFTVDYRVQCQNQWLAECKDKVIPGFSDFSLSHTLGDPIKIRAWQIAGLPVDSFSIDNGIIVSNSRRWALMIDPHGQANKWIKNMEKANKLAVIKFSDSNYMRMLENALQLGTPVLIENIGEELDASIEPILLKATFKQQGVEYMRLGENIIEYSRDFKLYITTRLRNPHYLPEVAVKVCLLNFMITPLGLQDQLLGIVAAKEKPELEEKKNQLIVESAKNKKHLKEIEDKILEVLSMSKGNILEDETAIKVLSSSKVLSEEISEKQKVASMTETQIDETRMGYKPVAVHSATIFFCISDLANIEPMYQYSLTWFINLYMHSLTHSTKSEELNLRIKYIIDHFTLSIYNNVCRSLFEKDKLLFSLLLTIGIMKQKKEITEEVWYFLLTGGIALDNPYPNPAPQWLSEKAWAEIVRASALPKLHGLMEHLEQNLGEWKLIYDSAWPHEEQLPGSWKFSQGLEKMVILRCLRPDKMVPAVREFIAEHMGKLYIEAPTFDLQGSYNDSSCCAPLIFVLSPSADPMAGLLKFADDLGMGGTRTQTISLGQGQGPIAAKMINNAIKDGTWVVLQNCHLAASWMPTLEKICEEVIVPESTNARFRLWLTSYPSEKFPVSILQNGIKMTNEPPKGLRANLLRSYLNDPISDPVFFQSCAKAVMWQKMLFGLCFFHAVVQERRNFGPLGWNIPYEFNESDLRISMWQIQMFLNDYKEVPFDALTYLTGECNYGGRVTDDKDRRLLLSLLSMFYCKEIEEDYYSLAPGDTYYIPPHGSYQSYIDYLRNLPITAHPEVFGLHENADITKDNQETNQLFEGVLLTLPRQSGGSGKSPQEVVEELAQDILSKLPRDFDLEEVMKLYPVVYEESMNTVLRQELIRFNRLTKVVRRSLINLGRAIKGQVLMSSELEEVFNSMLVGKVPAMWAAKSYPSLKPLGGYVADLLARLTFFQEWIDKGPPVVFWISGFYFTQSFLTGVSQNYARKYTIPIDHIGFEFEVTPQETVMENNPEDGAYIKGLFLEGARWDRKTMQIGESLPKILYDPLPIIWLKPGESAMFLHQDIYVCPVYKTSARRGTLSTTGHSTNYVLSIELPTDMPQKHWINRGVASLCQLDN", "length": 4116, "header": "sp|Q8TD57-1|DYH3_HUMAN Isoform 1 of Dynein axonemal heavy chain 3 OS=Homo sapiens OX=9606 GN=DNAH3 PE=1 SV=1 CANONICAL=Q8TD57-1" }, "locus": { "chromosome": "16", "start_pos": 21159441, "end_pos": 20933157, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000261383.3", "url": "https://www.ensembl.org/id/ENST00000261383.3" }, { "database": "Ensembl Peptide", "id": "ENSP00000261383.3", "url": "https://www.ensembl.org/id/ENSP00000261383.3" } ] } }, { "isoform_ac": "Q8TD57-2", "url": "https://www.uniprot.org/uniprotkb/Q8TD57/entry#Q8TD57-2", "sequence": { "sequence": "MGDMDCSSQKIAKSDSIHHMSHSQGQPELPPLPASANEEPSGLYQTVMSHSFYPPLMQRTSWTLAAPFKEQHHHRGPSDSIANNYSLMAQDLKLKDLLKVYQPATISVPRDRTGQGLPSSGNRSSSEPMRKKTKFSSRNKEDSTRIKLAFKTSIFSPMKKEVKTSLTFPGSRPMSPEQQLDVMLQQEMEMESKEKKPSESDLERYYYYLTNGIRKDMIAPEEGEVMVRISKLISNTLLTSPFLEPLMVVLVQEKENDYYCSLMKSIVDYILMDPMERKRLFIESIPRLFPQRVIRAPVPWHSVYRSAKKWNEEHLHTVNPMMLRLKELWFAEFRDLRFVRTAEILAGKLPLQPQEFWDVIQKHCLEAHQTLLNKWIPTCAQLFTSRKEHWIHFAPKSNYDSSRNIEEYFASVASFMSLQLRELVIKSLEDLVSLFMIHKDGNDFKEPYQEMKFFIPQLIMIKLEVSEPIIVFNPSFDGCWELIRDSFLEIIKNSNGIPKVESVLFPELKGYNLLLGTVNAEEKLVSDFLIQTFKVFQKNQVGPCKYLNVYKKYVDLLDNTAEQNIAAFLKENHDIDDFVTKINAIKKRRNEIASMNITVPLAMFCLDATALNHDLCERAQNLKDHLIQFQVDVNRDTNTSICNQYSHIADKVSEVPANTKELVSLIEFLKKSSAVTVFKLRRQLRDASERLEFLMDYADLPYEDIKLNSTLFLWPDQIEDIFDNSRNLLLHKRDQAEMDLIKRYRESLGLSWK", "length": 753, "header": "sp|Q8TD57-2|DYH3_HUMAN Isoform 2 of Dynein axonemal heavy chain 3 OS=Homo sapiens OX=9606 GN=DNAH3 PE=1 SV=1 CANONICAL=Q8TD57-1" }, "locus": {} }, { "isoform_ac": "Q8TD57-3", "url": "https://www.uniprot.org/uniprotkb/Q8TD57/entry#Q8TD57-3", "sequence": { "sequence": "MGATGRLELTLAAPPHPGPAFQRSKARETQGEEEGSEMQIAKSDSIHHMSHSQGQPELPPLPASANEEPSGLYQTVMSHSFYPPLMQRTSWTLAAPFKEQHHHRGPSDSIANNYSLMAQDLKLKDLLKVYQPATISVPRDRTGQGLPSSGNRSSSEPMRKKTKFSSRNKEDSTRIKLAFKTSIFSPMKKEVKTSLTFPGSRPMSPEQQLDVMLQQEMEMESKEKKPSESDLERYYYYLTNGIRKDMIAPEEGEVMVRISKLISNTLLTSPFLEPLMVVLVQEKENDYYCSLMKSIVDYILMDPMERKRLFIESIPRLFPQRVIRAPVPWHSVYRSAKKWNEEHLHTVNPMMLRLKELWFAEFRDLRFVRTAEILAGKLPLQPQEFWDVIQKHCLEAHQTLLNKWIPTCAQLFTSRKEHWIHFAPKSNYDSSRNIEEYFASVASFMSLQLRELVIKSLEDLVSLFMIHKDGNDFKEPYQEMKFFIPQLIMIKLEVSEPIIVFNPSFDGCWELIRDSFLEIIKNSNGIPKLKYIPLKFSFTAAAADRQCVKAAEPGEPSMHAAATAMAELKGYNLLLGTVNAEEKLVSDFLIQTFKVFQKNQVGPCKYLNVYKKYVDLLDNTAEQNIAAFLKENHDIDDFVTKINAIKKRRNEIASMNITVPLAMFCLDATALNHDLCERAQNLKDHLIQFQVDVNRDTNTSICNQYSHIADKVSEVPANTKELVSLIEFLKKSSAVTVFKLRRQLRDASERLEFLMDYADLPYQIEDIFDNSRNLLLHKRDQAEMDLIKRCSEFELRLEGYHRELESFRKREVMTTEEMKHNVEKLNELSKNLNRAFAEFELINKEEELLEKEKSTYPLLQAMLKNKVPYEQLWSTAYEFSIKSEEWMNGPLFLLNAEQIAEEIGNMWRTTYKLIKTLSDVPAPRRLAENVKIKIDKFKQYIPILSISCNPGMKDRHWQQISEIVGYEIKPTETTCLSNMLEFGFGKFVEKLEPIGAAASKEYSLEKNLDRMKLDWVNVTFSFVKYRDTDTNILCAIDDIQMLLDDHVIKTQTMCGSPFIKPIEAECRKWEEKLIRIQDNLDAWLKCQATWLYLEPIFSSEDIIAQMPEEGRKFGIVDSYWKSLMSQAVKDNRILVAADQPRMAEKLQEANFLLEDIQKGLNDYLEKKRLFFPRFFFLSNDELLEILSETKDPLRVQPHLKKCFEGIAKLEFTDNLEIVGMISSEKETVPFIQKIYPANAKGMVEKWLQQVEQMMLASMREVIGLGIEAYVKVPRNHWVLQWPGQVVICVSSIFWTQEVSQALAENTLLDFLKKSNDQIAQIVQLVRGKLSSGARLTLGALTVIDVHARDVVAKLSEDRVSDLNDFQWISQLRYYWVAKDVQVQIITTEALYGYEYLGNSPRLVITPLTDRCYRTLMGALKLNLGGAPEGPAGTGKTETTKDLAKALAKQCVVFNCSDGLDYKAMGKFFKGLAQAGAWACFDEFNRIEVEVLSVVAQQILSIQQAIIRKLKTFIFEGTELSLNPTCAVFITMNPGYAGRAELPDNLKALFRTVAMMVPDYALIGEISLYSMGFLDSRSLAQKIVATYRLCSEQLSSQHHYDYGMRAVKSVLTAAGNLKLKYPEENESVLLLRALLDVNLAKFLAQDVPLFQGIISDLFPGVVLPKPDYEVFLKVLNDNIKKMKLQPVPWFIGKIIQIYEMMLVRHGYMIVGDPMGGKTSAYKVLAAALGDLHAANQMEEFAVEYKIINPKAITMGQLYGCFDQVSHEWMDGVLANAFREQASSLSDDRKWIIFDGPVDAIWIENMNTVLDDNKKLCLMSGEIIQMNSKMSLIFEPADLEQASPATVSRCGMIYMEPHQLGWKPLKDSYMDTLPSSLTKEHKELMKSGQ", "length": 1887, "header": "sp|Q8TD57-3|DYH3_HUMAN Isoform 3 of Dynein axonemal heavy chain 3 OS=Homo sapiens OX=9606 GN=DNAH3 PE=1 SV=1 CANONICAL=Q8TD57-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2076, "start_aa": "Thr", "end_pos": 2076, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2076", "evidence": [ { "id": "GLY_001151", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001151" } ], "filter_code": "00000000000000001000.00000000001000.0.01001" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2265, "start_aa": "Thr", "end_pos": 2265, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2265", "evidence": [ { "id": "GLY_001151", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001151" } ], "filter_code": "00000000000000001000.00000000001000.0.01001" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2650, "start_aa": "Thr", "end_pos": 2650, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2650", "evidence": [ { "id": "GLY_001151", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001151" } ], "filter_code": "00000000000000001000.00000000001000.0.01001" }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_pos": 3835, "start_aa": "Ser", "end_pos": 3835, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser3835", "evidence": [ { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "Q8TD57", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8TD57" }, { "id": "Q8TD57", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q8TD57" } ], "filter_code": "00000000000000010000.0000000.00000001000000.1000000.0100000000.110100100001111011.10000.01000" } ], "phosphorylation": [ { "start_pos": 1500, "end_pos": 1500, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { 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KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE", "evidence": [ { "database": "UniProtKB", "id": "Q8TD57", "url": "https://www.uniprot.org/uniprotkb/Q8TD57" } ], "reference": [ { "type": "PubMed", "id": "16959974", "url": "https://glygen.org/publication/PubMed/16959974" } ] }, { "title": "Two preferentially expressed proteins protect vascular endothelial cells from an attack by peptide-specific CTL.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2012-06-01", "authors": "Thommen Daniela S, Schuster Heiko, Keller Mario, Kapoor Sarika, Weinzierl Andreas O, Chennakesava Cuddapah S, Wang Xueya, Rohrer Lucia, von Eckardstein Arnold, Stevanovic Stefan, Biedermann Barbara C", "evidence": [ { "database": "IEDB", "id": "194203", "url": "https://www.iedb.org/epitope/194203" } ], "reference": [ { "type": "PubMed", "id": "22544926", "url": "https://glygen.org/publication/PubMed/22544926" } ] }, { "title": "Impact of genomic polymorphisms on the repertoire of human MHC class I-associated peptides.", "journal": "Nature communications", "date": "2014-04-09", "authors": "Granados Diana Paola, Sriranganadane Dev, Daouda Tariq, Zieger Antoine, Laumont C\u00e9line M, Caron-Lizotte Olivier, Boucher Genevi\u00e8ve, Hardy Marie-Pierre, Gendron Patrick, C\u00f4t\u00e9 Caroline, Lemieux S\u00e9bastien, Thibault Pierre, Perreault Claude", "evidence": [ { "database": "IEDB", "id": "213080", "url": "https://www.iedb.org/epitope/213080" } ], "reference": [ { "type": "PubMed", "id": "24714562", "url": "https://glygen.org/publication/PubMed/24714562" } ] }, { "title": "The nature and extent of contributions by defective ribosome products to the HLA peptidome.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2014-04-22", "authors": "Bourdetsky Dmitry, Schmelzer Christian E H, Admon Arie", "evidence": [ { "database": "IEDB", "id": "505995", "url": "https://www.iedb.org/epitope/505995" } ], "reference": [ 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Claus, Neri Dario, Fugmann Tim", "evidence": [ { "database": "IEDB", "id": "505995", "url": "https://www.iedb.org/epitope/505995" }, { "database": "IEDB", "id": "625585", "url": "https://www.iedb.org/epitope/625585" } ], "reference": [ { "type": "PubMed", "id": "26992070", "url": "https://glygen.org/publication/PubMed/26992070" } ] }, { "title": "Deciphering HLA-I motifs across HLA peptidomes improves neo-antigen predictions and identifies allostery regulating HLA specificity.", "journal": "PLoS computational biology", "date": "2017-08", "authors": "Bassani-Sternberg Michal, Chong Chlo\u00e9, Guillaume Philippe, Solleder Marthe, Pak HuiSong, Gannon Philippe O, Kandalaft Lana E, Coukos George, Gfeller David", "evidence": [ { "database": "IEDB", "id": "717098", "url": "https://www.iedb.org/epitope/717098" } ], "reference": [ { "type": "PubMed", "id": "28832583", "url": "https://glygen.org/publication/PubMed/28832583" } ] }, { "title": "High-throughput and Sensitive Immunopeptidomics 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W", "evidence": [ { "database": "IEDB", "id": "625585", "url": "https://www.iedb.org/epitope/625585" }, { "database": "IEDB", "id": "1357706", "url": "https://www.iedb.org/epitope/1357706" }, { "database": "IEDB", "id": "1359921", "url": "https://www.iedb.org/epitope/1359921" }, { "database": "IEDB", "id": "1376084", "url": "https://www.iedb.org/epitope/1376084" } ], "reference": [ { "type": "PubMed", "id": "32387766", "url": "https://glygen.org/publication/PubMed/32387766" } ] }, { "title": "Multiplexed relative and absolute quantitative immunopeptidomics reveals MHC I repertoire alterations induced by CDK4/6 inhibition.", "journal": "Nature communications", "date": "2020-06-02", "authors": "Stopfer Lauren E, Mesfin Joshua M, Joughin Brian A, Lauffenburger Douglas A, White Forest M", "evidence": [ { "database": "IEDB", "id": "1085190", "url": "https://www.iedb.org/epitope/1085190" }, { "database": "IEDB", "id": "1085222", "url": "https://www.iedb.org/epitope/1085222" } ], "reference": 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Stephen Q, Chen Weisan, Ramarathinam Sri H, Lim Kam Sian Terry C C, Croft Nathan P, Li Chen, Ayala Rochelle, Cebon Jonathan S, Purcell Anthony W, Schittenhelm Ralf B, Behren Andreas", "evidence": [ { "database": "IEDB", "id": "1983118", "url": "https://www.iedb.org/epitope/1983118" } ], "reference": [ { "type": "PubMed", "id": "32938616", "url": "https://glygen.org/publication/PubMed/32938616" } ] }, { "title": "Biogenesis of HLA Ligand Presentation in Immune Cells Upon Activation Reveals Changes in Peptide Length Preference.", "journal": "Frontiers in immunology", "date": "2020", "authors": "Marino Fabio, Semilietof Aikaterini, Michaux Justine, Pak Hui-Song, Coukos George, M\u00fcller Markus, Bassani-Sternberg Michal", "evidence": [ { "database": "IEDB", "id": "1870599", "url": "https://www.iedb.org/epitope/1870599" } ], "reference": [ { "type": "PubMed", "id": "32983136", "url": "https://glygen.org/publication/PubMed/32983136" } ] }, { "title": "The Impact of Biomaterial Cell Contact on the Immunopeptidome.", "journal": "Frontiers in bioengineering and biotechnology", "date": "2020", "authors": "Ghosh Michael, Hartmann Hanna, Jakobi Meike, M\u00e4rz L\u00e9o, Bichmann Leon, Freudenmann Lena K, M\u00fchlenbruch Lena, Segan S\u00f6ren, Rammensee Hans-Georg, Schneiderhan-Marra Nicole, Shipp Christopher, Stevanovi\u0107 Stefan, Joos Thomas O", "evidence": [ { "database": "IEDB", "id": "1345542", "url": "https://www.iedb.org/epitope/1345542" } ], "reference": [ { "type": "PubMed", "id": "33392160", "url": "https://glygen.org/publication/PubMed/33392160" } ] }, { "title": "IFN\u03b3 Modulates the Immunopeptidome of Triple Negative Breast Cancer Cells by Enhancing and Diversifying Antigen Processing and Presentation.", "journal": "Frontiers in immunology", "date": "2021", "authors": "Goncalves Gabriel, Mullan Kerry A, Duscharla Divya, Ayala Rochelle, Croft Nathan P, Faridi Pouya, Purcell Anthony W", "evidence": [ { "database": "IEDB", "id": "1913541", "url": 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"database": "IEDB", "id": "2021265", "url": "https://www.iedb.org/epitope/2021265" }, { "database": "IEDB", "id": "2030801", "url": "https://www.iedb.org/epitope/2030801" }, { "database": "IEDB", "id": "2031333", "url": "https://www.iedb.org/epitope/2031333" }, { "database": "IEDB", "id": "2037230", "url": "https://www.iedb.org/epitope/2037230" }, { "database": "IEDB", "id": "2037252", "url": "https://www.iedb.org/epitope/2037252" }, { "database": "IEDB", "id": "2040857", "url": "https://www.iedb.org/epitope/2040857" }, { "database": "IEDB", "id": "2041343", "url": "https://www.iedb.org/epitope/2041343" }, { "database": "IEDB", "id": "2043117", "url": "https://www.iedb.org/epitope/2043117" }, { "database": "IEDB", "id": "2047442", "url": "https://www.iedb.org/epitope/2047442" }, { "database": "IEDB", "id": "2048642", "url": "https://www.iedb.org/epitope/2048642" }, { "database": "IEDB", "id": "2052161", "url": "https://www.iedb.org/epitope/2052161" }, { "database": "IEDB", "id": "2055099", "url": "https://www.iedb.org/epitope/2055099" }, { "database": "IEDB", "id": "2056985", "url": "https://www.iedb.org/epitope/2056985" }, { "database": "IEDB", "id": "2060311", "url": "https://www.iedb.org/epitope/2060311" }, { "database": "IEDB", "id": "2060331", "url": "https://www.iedb.org/epitope/2060331" } ], "reference": [ { "type": "PubMed", "id": "35051231", "url": "https://glygen.org/publication/PubMed/35051231" } ] }, { "title": "Deciphering the landscape of phosphorylated HLA-II ligands.", "journal": "iScience", "date": "2022-05-20", "authors": "Solleder Marthe, Racle Julien, Guillaume Philippe, Coukos George, Bassani-Sternberg Michal, Gfeller David", "evidence": [ { "database": "iPTMnet", "id": "Q8TD57", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8TD57" } ], "reference": [ { "type": "PubMed", "id": "35494241", "url": "https://glygen.org/publication/PubMed/35494241" } ] }, { "title": "Multi-Omic Analysis of Two Common P53 Mutations: Proteins Regulated by Mutated P53 as Potential Targets for Immunotherapy.", "journal": "Cancers", "date": "2022-08-17", "authors": "Vadakekolathu Jayakumar, Boocock David J, Pandey Kirti, Guinn Barbara-Ann, Legrand Antoine, Miles Amanda K, Coveney Clare, Ayala Rochelle, Purcell Anthony W, McArdle Stephanie E", "evidence": [ { "database": "IEDB", "id": "2141965", "url": "https://www.iedb.org/epitope/2141965" } ], "reference": [ { "type": "PubMed", "id": "36010968", "url": "https://glygen.org/publication/PubMed/36010968" } ] }, { "title": "Bi-allelic variants in DNAH3 cause male infertility with asthenoteratozoospermia in humans and mice.", "journal": "Human reproduction open", "date": "2024", "authors": "Meng Gui-Quan, Wang Yaling, Luo Chen, Tan Yu-Mei, Li Yong, Tan Chen, Tu Chaofeng, Zhang Qian-Jun, Hu Liang, Zhang Huan, Meng Lan-Lan, Liu Chun-Yu, Deng Leiyu, Lu Guang-Xiu, Lin Ge, Du Juan, Tan Yue-Qiu, Sha Yanwei, Wang Lingbo, He Wen-Bin", "evidence": [ { "database": "UniProtKB", "id": "Q8TD57", "url": "https://www.uniprot.org/uniprotkb/Q8TD57" } ], "reference": [ { "type": "PubMed", "id": "38312775", "url": "https://glygen.org/publication/PubMed/38312775" } ] }, { "title": "DNAH3 deficiency causes flagellar inner dynein arm loss and male infertility in humans and mice.", "journal": "eLife", "date": "2024-11-06", "authors": "Wang Xiang, Shen Gan, Yang Yihong, Jiang Chuan, Ruan Tiechao, Yang Xue, Zhuo Liangchai, Zhang Yingteng, Ou Yangdi, Zhao Xinya, Long Shunhua, Tang Xiangrong, Lin Tingting, Shen Ying", "evidence": [ { "database": "UniProtKB", "id": "Q8TD57", "url": "https://www.uniprot.org/uniprotkb/Q8TD57" } ], "reference": [ { "type": "PubMed", "id": "39503742", "url": "https://glygen.org/publication/PubMed/39503742" } ] }, { "title": "Novel bi-allelic DNAH3 variants cause oligoasthenoteratozoospermia.", "journal": "Frontiers in endocrinology", "date": "2024", "authors": "Li Shu, Zhang Zexin, Xie Linna, Zhao Yanqiu, Chen Hongtai, Zhang Shijia, Cai Yixiang, Ren Bingjie, Liu Wensheng, Tang Songxi, Sha Yanwei", "evidence": [ { "database": "UniProtKB", "id": "Q8TD57", "url": "https://www.uniprot.org/uniprotkb/Q8TD57" } ], "reference": [ { "type": "PubMed", "id": "39588341", "url": "https://glygen.org/publication/PubMed/39588341" } ] }, { "title": "Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.", "journal": "FEBS Lett.", "date": "1997", "authors": "Chapelin C, Duriez B, Magnino F, Goossens M, Escudier E, Amselem S", "evidence": [ { "database": "UniProtKB", "id": "Q8TD57", "url": "https://www.uniprot.org/uniprotkb/Q8TD57" } ], "reference": [ { "type": "PubMed", "id": "9256245", "url": "https://glygen.org/publication/PubMed/9256245" } ] }, { "title": "Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.", "journal": "Gene", "date": "1997", "authors": "Neesen J, Koehler M R, Kirschner R, Steinlein C, Kreutzberger J, Engel W, Schmid M", "evidence": [ { "database": "UniProtKB", "id": "Q8TD57", "url": "https://www.uniprot.org/uniprotkb/Q8TD57" } ], "reference": [ { "type": "PubMed", "id": "9373155", "url": "https://glygen.org/publication/PubMed/9373155" } ] } ], "pathway": [ { "id": "hsa:55567", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:55567", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6GLR7-1", "protein_name": "Dynein axonemal heavy chain 3", "gene_name": "Dnah3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSQIDCSSQKLDKSDSIHHMSHSQARPELPPLPVSANEEPSEIYKTVMSHSFYPPLMQRTSWTLAVPFKEQDQHRGPSDSIGNNYSLTARDMKLKDLVKVYQPVTISVPRDKASQGLPLASKTSTEPSKKKMKLCIKGKDDATGTPLACKHSSSSNMKNATDSSLTYPESRPMSPEQQMDVMLQQEMEVESKENKPSELDLERYYYYLTNGIRKDMIAPEDEDVMVRIYKLIPKTLLTTPALEPLQVSLRSEKESDYYYSLMKSIVDYILMDPLEKKRLFIKSIPRLFPHRVIRAPVPWHNIYQSVKKWNEEHLHTVNPMMYTLKELWFSEFKDLRFIRTADLLAGKLPLLPHEYQEEIQKHCLDARQVLLSKWIPTCAQLFVTQKERWVHFAPKNDYDSSRNIEEYFASVASFMSLQLRELVIKSLGDLVSFFMIHKDGNDFNEPYQEMDFFIPQLITIKLEVDDPVIVFNPTFDDCWQLIKESFLEIIKNSNGIPKVESILFPDLKGYNMILGTVDPEENLVADFLNQTLEVFNKNQVGPHKYLNVYKKYDDLLDNTAEQDISTFLNDKHDIDDFVTSINSIKKRRNEIASMHITVPLAMFCLDAVLLNHDLCERAQNLKDRLIQYQVDVNRETNTSICNQYSTIADKVSETPANTAELVALIEYLKKSSDVTVFKLRRQLRDASERLEFLMDYADLPNEDIKLNSNLFLWPDQIEDVFENSRNLLLSKRDQAEMDLIKRCSEFETRLEGYSKELEMFRKREVMTTEEMKNNVEKLNDLSKNLDLALTEFELINKEEELLEKEKSSFPLLQVLMVNKIPYEQLWVTAYEFSTKSEEWMNGPLFLLNAEEIAEDIGNMWRTTYKLTKTLIDVPAPRRLAENVKLKIEKFRQHIPVLTIACNPGMKDRHWQQISDIVGYEIKPTETTCLANMLEFGFSKFVDKLEPIGAAASKEYSLEKNLEKMKSDWVNMCFSFVKYRDTDTSILCAVDDIQLLLDDHVIKTQTMCGSVFIKPIEAECRKWEEKLVRVQENLDAWLKCQATWLYLEPIFSSEDIIAQMPEEGKKFGIVDSYWKSLMAQAVNDTRVLVAADQPRMTEKLQEANVLLEDIQRGLNDYLEKKRLFFPRFFFLSNDELLEILSETKDPLRVQPHLKKCFEGIAKLEFTDNLEIKGMISSEKEIVPFIQTIYPVKAKGMVEKWLQQVEQVMVASMRQVIEDGIEAYLKVPRNAWVLQWPGQVVICVSSIFWTREVSEALVEYTLTDFLKKSNDQIAQIVELVRGKLSSGARLTLGALTVIDVHARDVVAKLEQDNINSLNDFQWISQLRYYWVESNVQVQMITTQALYGYEYLGNSPRLVITPLTDRCYRTLMGALKLNLGGAPEGPAGTGKTETTKDLAKALAKQCVVFNCSDGLDYKAMGKFFKGLAQAGAWACFDEFNRIEVEVLSVVAQQILSIQQAIIRKLKMFIFEGTELSLNPTCAVFITMNPGYAGRAELPDNLKALFRTVAMMVPDYALIGEISLYSMGFLDSRSLAQKIVATYRLCSEQLSSQHHYDYGMRAVKSVLTAAGNLKLKYPEENESVLLLRALLDVNLAKFLAQDVPLFQGIISDLFPGVVLPKPDYEVFLEALNNNIRNMKLQPVPWFIGKIIQIYEMMLVRHGYMIVGDPMGGKTSAYKVLAAALGDLHAANQMEEFAVEFKIINPKAITMGQLYGYFDAVSHEWTDGVLANAFREQASSVTDERKWIIFDGPVDAVWIENMNTVLDDNKKLCLMSGEIIQMSSKMSLIFEPADLEQASPATVSRCGMIYMEPHQLGWKPLKDSYMDTLPPCLNKEHTELVEDMFTWLVQPCLDFNRLHSKFVVQTSPIHLAFSMMRLYSSLLDELWAIQEEEMEIYEGLSSQQIFLWLQGLFLFSLVWTVAGTINAESRKKFDVFFRNLIMGMDDHNPRPKSVKLTKNNIFPERGSIYDFYFLKQGGGHWNAWTEYITKEEETIPANAKVSDLIIPTMETARQTFFLKTYLDHEIPILFVGPTGTGKSAITNNFLLHLPKNVYQPNFINFSARTSANQTQDIIMSKLDRRRKGLFGPPIGKKAVVFVDDLNMPAKEVYGAQPPIELLRQWIDHGYWFDKKDTNRLDIVDVLLVTAMGPPGGGRNDITGRFTRHLNLLSINAFEDEILTKIFSSIADWHFGKGFDVMFLRYGRMLVQATQIIYRAAVENFLPTPSKSHYVFNLRDFSRVIQGVLLCPHTHLQDLEKFIRLWIHEVYRVFYDRLIDNDDRQTFFNLVKETTSNCFKQTVEKVLIHLSPTGKITDENIRSLFFGDFLKPESDQKIYDEIIDLRNLTVVMEYYLDEFNSVSKAPMSLVMFKFAIEHISRICRVLKQNKGHLLLVGIGGSGRQSATKLSTFMNSYELYQIEITKNYTGNDWREDLKKIMLQSGVATKSTVFLFADNQIKDESFVEDINMLLNTGDVPNIFPADEKADLVEKMQTAARTGGEKIEVTPLSMYNFFIERVRKNLHIVLAMSPIGDAFRTRLRMFPSLINCCTIDWFQSWPTDALELVANKFLEDVELDDNIRAEVVSMCKYFQESAKKLSVDYYNTLLRHNYVTPTSYLELILTFKTLLNSKRHEVDLMRNRYLAGLQKLEFASSQVAVMQVELTALQPQLIQTSENTAMMMVKIEMETKEADAKKLLVQADEKEANAAAAVAQAIKNECEGDLAEAMPALEAALAALDTLNPADITLVKSMQNPPGPVKLVMESICVMKGLKPERKPDPSGSGKMIEDYWGVSRKILGDLKFLESLKTYDKDNISPVIMKRIRERFIDHPDFQPAVIKNVSSACEGLCKWVRAMEVYDRVAKVVAPKRERLREAEGKLEIQMHKLNQKRAELKLVEDRLQALNDEFELMNSKKNMLEENIEICSQKLIRAEKLISGLGGEKDRWTEAARLLGIRYDNLTGDVLLSSGTVAYLGAFTVDYRAQCQTEWLISCKDKVIPGSVDFSLSNTLGDPIKIRAWQIAGLPVDSFSVDNGIIVSNSRRWPLMIDPQGQANKWVKNMEKTNKLSVIKFSDTNYVRTLENALQFGTPVLLENVGEELDAFIEPILLKATFKQQGVEYMRLGENIIEYSREFKFYITTRLRNPHYLPEVAVKVCLLNFMITPLGLQDQLLGIVAAKEKPELEEKKNKLILESAENKKQLKEIEDKILEVLSLSEGNILEDETAIKVLSSSKILSEEISEKQEIASVTETQIDETRMGYKPVAIHSAAIFFCISDLAHIEPMYQYSLTWFINLYVLSLANSNKSDELDLRIEYIIEHFTLSIYNNVCRSLFEKDKLLFSLLLTIGLLKEKKAIDEEVWYFLLTGGVALDNPFPNPAPEWLSEKSWGEIVRASSLPKLKGLMDDLSRNLTEWKAIYDSAWPQDESLPSPWVFLQALEKMAILRCLRPDKIVPAIQDFISETMGKVFIEAPTFDLQGSYNDSSCCAPLIFILSPGADPMAGLLKFADDLGMGGTKTQTISLGQGQGPIAAKMIHKAIHEGTWVVLQNCHLATSWMPALEKICEEVIIPENTNRDFRLWLTSYPSEKFPVSILQNGIKMTNEPPKGLRANLLRSYLNDPISDPVFFQSCTKPVIWQKLLFGLCFFHAIVQERRNYGALGWNIPYEFNESDLRISMRQIQMFLNDYKEVPFEALTYLTGECNYGGRVTDDKDRRLLLSLLSTFYCKEIETDHYYIAPGQPYFIPPHGSYQSYIEYLRTLPITAHPGVFGLHENADITKDNQETNQLFQGVLLTLPRQSGGSGKSPQEVVEELAQDILSKLPKDFNLEEVMKLYPVVYEESMNTVLRQELIRFNRLTKVVRRSLIDLGRAIKGQVLMSSELEEVFNSMIVGKVPAMWAAKSYPSLKPLGGYVADLLARLAFFQEWINKGPPVVFWISGFYFTQSFLTGVSQNYARKYTIPIDHIGFEFEVTSKETTMENIPEDGAYIKGLFLEGARWDRTIRQIGESLPKILYDPLPIIWLKPGESASFLHQDIYVCPVYKTSARRGTLSTTGHSTNYVLSIELPTDMPQKHWINRGVASLCQLDN", "length": 4069 }, "evidence": [ { "id": "RGD:1305855", "url": "https://alliancegenome.org/gene/RGD:1305855#orthology", "database": "AGR" }, { "id": "HGNC:2949", "url": "https://alliancegenome.org/gene/HGNC:2949#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-091112-7", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-091112-7#orthology", "database": "AGR" }, { "id": "MGI:2683040", "url": "https://alliancegenome.org/gene/MGI:2683040#orthology", "database": "AGR" }, { "id": "FB:FBgn0035581", "url": "https://alliancegenome.org/gene/FB:FBgn0035581#orthology", "database": "AGR" }, { "id": "Q8TD57", "url": "https://omabrowser.org/oma/group/Q8TD57/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8M3ANU1-1", "protein_name": "Dynein axonemal heavy chain 3", "gene_name": "dnah3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MNANSSHHDVEYTGRIHRLPPLPTFQTPSDLYVIYLRNSQYPAILQDHSRTLAVPYKELQHHRSPSESIGNNYSPGGQNLKITHLNRRHHSRHCPSTPLHSDSALVRRLQPLTQRGRPLSPNQQLEIIRHEEKQRQRTQTEPTETDLERYLYYVTEGIYGHMLAPQPSKQISSILKLLPSRFQGDEEEMERMREDLLEEVQRDYEFSLRKSIVDYILLDPAERERLSISAVPQQFPSRVIRAPVPWSESYQEARSWQTENLFTVNPMLLHLEDLWMSSFSSLRFVNSDSLLSADLPLLPGEFEELVQRQCQNTKDELLNTWLPRCASLFVTFKDAWLPLLPKSSSIAPEKVEKLFRCVAALMSLQLRSLVIASLQDLLQFFQLHQDGNDFGERFDEMQYTQRPVLLVKLKLEDPRISFEPSLQGCWELIQQAFTQIISSAHNIPRVECKLFPEIGETLMLRSVQADEMLVKDIINTARETFQRNTIGPQRYLEVYKKYTHLLDHQDIVNFLKTKHSQQGFTKKITAVQNVWKDIASLHATVPLSLFCLDAVNLNQDLCDKAEHLIELLTTFVMEENRELNKSICHRYDEITDRITSKPSSTEELVELNKYLKHTSEVTIHKLRHEIEEAVKRLDFLLDYTTIQAEDMKLFSTVIHWPELILSSLEFSRDKLNNQKDEAEIHLMKRIGQLEETLKGLDKEVDIFKIKEKITLEEIKHNVEKLNNIGISLEAALKEIETSNKEESLLDKEQSQFPVLQTIIAKKQPYDQLWITALDFQTKSEMWMNGPFQQLNAETVSEDLGNMWRTMYKLAKSFPERTAPGRVTENFKKKIDKFKQHLPILTTICNPGLKDRHWEMISNTVGFDVKPDENTPLIKMVELGLSKYSDQLEEIGASASKEYSLEKSLEKMTREWAELHFMFAPYKDTGTSVLSAVDDIQLLLDDHIIKTQTMRGSPFIKPIEAEAKAWEEKLQRMQDILDGMLQCQSMWMYLEPIFSSEDIIAQMPENGRKFAIVDSYWKNIVAESLKDTHVLVATEQPNMLGRLQESNTFLEEIQQGLNSYLETKRLFFPRFFFLSNDEMLEILSETKDPLRVQPHLKKCFEGIAKLEFTPDLEITGMISSEKEIVPLIETIYPVKAKGMVEKWLLQVENTMLMSIRAVIKQGMEQYSEMPRKKWVLLWPGQVVICASCIFWTSEVSDAIQNNTLPSYVEQSNAQITDIVELVRGKLSGGARMTLGALIVIDVHARDVVCKLAQDGVSSLNDFQWISQLRYFWEDGEVMLRMITTAIRYGYEYLGNSPRLVITPLTDRCYRTLMGALKLNLGGAPEGPAGTGKTETTKDLAKALAKQCVVFNCSDGLDYKAMSKFFKGLAQSGAWACFDEFNRIEVEVLSVVAQQILSIQQAVMRNMKTFMFEGTELSLNPTCCVFITMNPGYAGRAELPDNLKALFRTVAMMVPDYGLIGEISLYSMGFTASRSLAQKIVATYRLCSEQLSSQPHYDYGMRAVKSVLTAAGNLKLKYPEEDEIVLLLRALMDVNMAKFVAQDLPLFQGIITDLFPGVVLAKPDYELLLKALHDNIGKMKLQPVPWFISKIIQVYEMMLVRHGFMIVGEPMGGKTSAYKVLAGALGDLYKEGLIEEFAVDFRIINPKAVTMGQLYGCFDPVSHEWSDGVLATSFRQQAQCTNDDRQWIIFDGPIDAVWIENMNTVLDDNKKLCLMSGEIIQMSPKMSLIFEPADLEQASPATVSRCGMIYMEPHQLGWTPLRDSYMNTLPESLADEHRTLIADLFNWLVQPCLDFIYHECGFLVQTSPIHLAYSLMRLYTCLLDEIFQEGAESMTSQQMTLWLQSLFLFAVVWSLGGTVNGNSRNKFDTFYRNLLMGTITDHPRPMSVKLTKNNGFPERGTVYDYYFHKQGPGQWNNWTESIAKEDRVIPAGAKVSDLIIPTAETSRQLFFLRTYLSHEVPVLIVGPTGTGKSVINNNFLMSLSKERYTPICINFSARTSANQTQDIIMSKLDRRRKGVFGPPVGKKCIIYVDDLNMPAKEIYGAQPPIELLRQWIDHHHWYDKKDTSRLDIEDVLYMSAMGPPGGGRNDITGRFTRHLNILSIDTFDDETLSNIFTSITDWHFSNGFDASFYRLGKIMVQATMAVYKDAIESFLPTPSKSHYIFNLRDFARVIRGVMLCPSTHMQEGDKVIRLWIHEVYRVFYDRLVDNDDRGKFFNIVKERTSAYFKLSLDKLLGHLTLSGKVEDDSIRSLFFGDYSKPDSANKQYDEITDLSTLTEVMDFYLREFNNISKAPMNLVMFQFAIEHISRICRVLKQDNGHLLLVGIGGSGRQSATKLATFINDYELFQIELTKNYSMSDWRDNLKHLMLKSGIEGKKTTFLFSDSQIKDEAFVEDINMLLNTGDVPNIFPLDERADIIEKMQGIAQMEGKKIDVTPLSMYNFFIDRVKTNLHIVLAMSPIGEDFRNRLRMFPSLINCCTIDWFQAWPKDALEMVANKFLEDLDLEDDIRIEVVEMCKTFQESVRELSERYYSQLRRHNYVTPTSYLELILTFKALLNSKRSEVNELRNRYIVGLQKLDFASSQVAVMQQELTALQPELIETAKQTDQMMVKIEKETVEVDAKKELVSADEKVANEAAAAAKAIKDECEGDLAEAMPALEAALAALDTLKPADITVLKTMQNPPGPVKLVMESICVMKGIKPERKQDPGGSGKMIEDFWGPSKKILGDMKFLESLKTFNKDNIPPASIKKIREKFIDHPDFQPSVIKSVSSACEGLCKWVRAMEVYERVAKVVAPKKEKLKEAEEELAVQMQKLNVKRAELKEVEDRLQALNDTFEGMIQKKKDLEANIELCSQKLVRAEKLIGGLGGEKDRWTEAARLLGIKYNNLTGDVLLSSATVSYLGAFTVDYRVECQQQWLELCNRKKIPYSEDFTLGNTLGNQVLIRSWQIAGLPVDLFSTDNGIIVSNSRRWPLMIDPQGQANKWIKNMNKANKLSVIKLSDSNYVRSLENAIQFGTPVLLENVGEELDAVLEPVLLKQTFKQQGVEYMKLGENTIEYSRDFRFYITTGLRNPHYLPEVAVKVCLLNFMITPLGLEDQLLGIVATKEKPELEEKKNQLILESAANNKQLKEIENQILQVLSSSEGNILEDETAITVLSSSKLLSEEISEKQKIASVTESEIDETRMGYRPVAEHSSILFFCISDLANIDPMYQYSLTWFINLYLQSIAHSVPSDDLQIRIANILDHFTLRVYYNVCRSLFEKDKLLFSLLLTVGIMQGKGQVDDIVWRFLLTGGVALENPHPNPAPEWLSDKSWSEVVRASQLSRLEGLFEHVQENIALWKQIYDSGHPQDEELPGKWHTVVGMERMVVLRCFRPDKLVPAVQKFIVDNIGRAYIEPPTFDLAESYSDSNCCSPLIFVLSPGSDPTAGLLKFADDLGMGGSRTQTISLGQGQGPVAEQLIKAALSVGHWVVLQNCHLATSWMPTLEKICEEVITPENTHTSFRLWLTSQPSDKFPVSVLQNGVKMTNEPPKGLRANLLRSYLSDPISDPTFFNSSARQEIWQKLLFGLCFFHALVQERRTFGPLGWNIPYEFNESDLRISIRQIQMFLDEYEEVPLEALTYLTGECNYGGRVTDDKDRRLLMSLLSIFYSWQLIQQDQYRVCEGDLYYVPSHAPYQSYVDYIRNLPISAEPEVFGLHSNANITKDNQETNQLLDGVLLTLPRQTNSGAKSPQEVVDELAEGMLAKLPCDFDIEMVTNKYPLLYEESMNTVLRQELIRFNRLSKVVRSSLLNTQKALRGQVVMSSELENVFNSLLVGKVPAMWAAKSYPSLKPLGSYVSDFLARLQFLQDWIDNGPPSVFWVSAFYFTQSFLTGVSQNFARKYTIPIDYIGFEFEVCKQETHMEEKPEDGAYIRGLFLEGARWNREHMVIGESVPKVLFDSLPIIWLKPGESATFLHQNVYVCPVYKTSARRGTLSTTGHSTNYVLSIELPSDQPQKHWVNRGVACLCQLDN", "length": 4007 }, "evidence": [ { "id": "RGD:1305855", "url": "https://alliancegenome.org/gene/RGD:1305855#orthology", "database": "AGR" }, { "id": "HGNC:2949", "url": "https://alliancegenome.org/gene/HGNC:2949#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-091112-7", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-091112-7#orthology", "database": "AGR" }, { "id": "MGI:2683040", "url": "https://alliancegenome.org/gene/MGI:2683040#orthology", "database": "AGR" }, { "id": "FB:FBgn0035581", "url": "https://alliancegenome.org/gene/FB:FBgn0035581#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8BW94-1", "protein_name": "Dynein axonemal heavy chain 3", "gene_name": "Dnah3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSDTNCSAQKLDKSDSVHHMSHSQARPELPPLPVSANEEPSELYKTVMSHSFYPPLMQRTSWTLAVPFKEQDHHRGPSDSIGNNYSLTARDMKLKDLLKVYQPVTISIPRDKTSQGLPLGTSSKTSTEPSKKKMKFNLKAKDDVTGMPFVCKFSSSLSIKNTTDSSVTHPESRPMSPEQQMDVMLQQEMEIESKEQKPSELDLERYYYYLTNGIRKDMIAPENEEVMMRIYKLIPKTLLTTPALEPLQVSLRSEKESDYYYSLMKSIVDYILMDPMEKKRLFIKSIPRLFPHRVIRAPVPWHNIYQSTKKWNEEHLHTVNPMMYKLKELWFAEFQNLRFVRTADLLAGKLPLLPHEYKEVVQKHCREARHILLTKWIPTCAQLFVTQKEHWVHFAPKNDYDSSRNIEEYFASVASFMSLQLRDLVIKSLRDLVSFFMIHKDGNDFKEPYQEMDFFIPQLIMIKLEVRDPIIVFNPTFDDCWQLIKNSFLEIIKNSDGIPKVYLCWKPLASYICVSPHLRMTSVLQVESILFPDLKGYNMILGTVNPEESLVSDFLDQTLEVFKKNQVGPYKYLNVYKKYDDLLDNMAEKGISEFLKEKHEIEDFVTSINSIKKRKNEIASMHITVPLAMFCLDAVFLNYDLCERAQNLKDNLILYQVDVNRETNTSICNQYSTIADKVSEIPANTAELVALIEYLKKSSDVTVFKLRRQLRDASERLEFLMDYADLPSESIEDVFESSRNLLMSKRDQAEMDLIKRCSEFESRLEGYSKELEMFRKREVMTTEEMKNNVEKLHDLSKNLDLALTEFELINKEEELLEKEKSSFPLLQTLMINKIPYEQLWVTAYEFSTKSEEWMNGPLYLMNAEQIAEEIGNMWRTTYKLTKTLIDVPAPKRLAENVKLKIEKFKQHIPILNIACNPGMKDRHWQQISDIVGYEIKPTETTCLANMLEYGFGKFVDKLEPIGAAASKEYSLEKNLEKMKADWVNMCFSFVKYRDTDTSILCAVDDIQLILDDHVIKTQTMCGSVFIKPIEAECRKWEEKLVRVQENLDAWLKCQVTWLYLEPIFSSEDIIAQMPEEGKKFTTVDTYWKSLMAQAVNDTRVMVAADQPRMTEKLQEANVLLEDIQRGLNDYLEKKRLFFPRFFFLSNDELLEILSETKDPLRVQPHLKKCFEGIAKLEFTDNLEIKGMISSEKETVPFIQTIYPVKAKGMVEKWLQQVEQVMLASMRQVIENGIEAYVQVPRNAWVLEWPGQVVICVSSIFWTREVSEALVEDTLTDFLKKSNDQIAQIVELVRGKLSSGARLTLGALTVIDVHARDVVAKLRHDHINSLNDFQWISQLRYYWTEKNVHVQMITTEALYGYEYLGNSPRLVITPLTDRCYRTLMGALKLNLGGAPEGPAGTGKTETTKDLAKALAKQCVVFNCSDGLDYKAMGKFFKGLAQAGAWACFDEFNRIEVEVLSVVAQQILSIQQAIIRKLKRFIFEGTELSLNPTCAVFITMNPGYAGRAELPDNLKALFRTVAMMVPDYALIGEISLYSMGFLDSRSLAQKIVATYRLCSEQLSSQHHYDYGMRAVKSVLTAAGNLKLKYPEENESVLLLRALLDVNLAKFLAQDVPLFQGIISDLFPGVVLPKPDYEVFLEALNNNIRKMKLQPVPWFIGKIIQIYEMMLVRHGYMIVGDPMGGKTSAYKVLAAALGDLHAANQMEEFAVEFKIINPKAITMGQLYGCFDAVSHEWTDGVLANAFREQASSITDDRKWIIFDGPVDAVWIENMNTVLDDNKKLCLMSGEIIQMSSKMSLIFEPADLEQASPATVSRCGMIYMEAHQLGWKPLKDSYMDTLPRCLTKEHTELVEDMFTWLVQPCLDFSRLHCKFVVQTSPIHLAFSMMRLYSSLLDEIRDIQEEEMEIYEGLSSQQIFLWLQGLFLFSLVWTLAGTINAESRKKFDVFFRNLIMGMDDRNPRPKSVKLTKNNIFPERGSIYDFYFLKQGGGHWNAWTEYITKEEETIPANAKVSDLIIPTMETARQSFFLKTYLDHEIPILFVGPTGTGKSAITNDFLLHLPKNVYQPNFINFSARTSANQTQDIIMSKLDRRRKGLFGPPIGKKAVVFVDDLNMPAKEVYGAQPPIELLRQWIDHGYWFDKKDTNRLDIVDVLLVTAMGPPGGGRNDITGRFTRHLNIISINAFEDEILTKIFSSIADWHFGKGFDVMFLRYGKMLVQATQTIYRAAVENFLPTPSKSHYVFNLRDFSRVIQGVLLCPHTHLQDLEKFIRLWIHEVYRVFYDRLIDNDDRQTFFNLVKETTSNCFKQTMEKVLIHLSPTGKITDDNIRSLFFGDYLKPESDQKIYDEIIDLRGLTVVMEYYLDEFNSVSKAPMSLVMFKFAIEHISRICRVLKQKKGHLLLVGIGGSGRQSATKLSTFMNSYELYQIEITKNYTNSDWREDLKKIMLQSGVATKSTVFLFSDNQIKHESFVEDINMLLNTGDVPNIFPADEKADLVEKMQTAARTEGEKVEATPLSMYNFFIERGTNRAYFSLAMSPIGDAFRTRLRMFPSLINCCTIDWFQSWPTDALELVANKFLEDVELDDNIRAEVVSMCKYFQESVKKLSVDYYNTLLRHNYVTPTSYLELILTFKTLLNSKRQEVDTIRNRYLAGLQKLEFASSQVAVMQVELTALQPQLIQTSEDTAMMMVKIELETKEADAKKLLVQADEKEANAAAAISQAIKNECEGDLAEAMPALEAALAALDTLNPSDITLVKSMQNPPGPVKLVMESICVMKGLKPERKPDPSGSGKMIEDYWGVSRKILGDLKFLESLKTYDKDNIPSVIMKRIRERFIDHPDFQPAVIKNVSSACEGLCKWVRAMEVYDRVAKVVAPKRERLREAEGKLEIQMQKLNQKRAELKLVEDRLQDLNDEFELMNRKKNSLEKNIEICSQKLVRAEKLISGLGGEKDRWTEAARQLGIRYDNLTGDVLLASGTVAYLGAFTVDYRAQCQNEWLVSCKDKVIPGSVDFSLSNTLGDPIKIRAWQIAGLPVDSFSVDNGIIVSNSRRWPLMIDPQGQANKWVKNMEKTNKLSVIKFSDTNYVRTLENALQFGTPVLLENVGEELDAFIEPILLKATFKQQGVEYMRLGENIIEYSREFKFYITTRLRNPHYLPEVAVKVCLLNFMITPLGLQDQLLGIVAAKEKPELEEKKNKLILESAQNKKQLKEIEDKILEVLSLCEGNILEDETAIKILSSSKVLSEEISEKQEIASVTETQIDETRMGYKPVAVHSAAIFFCISDLAHIEPMYQYSLTWFINLYVQSLANSNKSDELDLRIEYIIEHFTLSIYNNVCRSLFEKDKLLFSLLLTVGLLKERKAIDEEVWYFLLTGGVALDNPFPNPAPEWLSEKSWGEIVRASSLQKLKGLMEDVMQNIKVWKDIYDSAWPHEESLPSPWFFLQTLEKIAILRCLRPDKIVPAIQNFICETMGKIFIEAPTFDLQGSYGDSSCCVPLIFILSPGADPMAGLLKFADDVSMGGTKTQTISLGQGQGPIAANMINKAIHEGTWVVLQNCHLATSWMPALEKICEEVIVPENTNSEFRLWLTSYPSEKFPVSILQNGIKMTNEPPKGLRANLLRSYLNDPISDPLFFQSCTKPVIWQKLLFGLCFFHAIVQERRNYGALGWNIPYEFNESDLRISMRQIQMFLNDYEEVPFEALTYLTGECNYGGRVTDDKDRRLLLSLLSMFYCKEIETDNYHIAPGDAYVIPPYGSYQSYIEYLRTLPITAHPEVFGLHENADITKDNQETNQLFQGVLLTLPRQSGGSGKSPQEVVEELAQDILSKLPNDFNLEEVMKKYPVVYKESMNTVLRQELIRFNRLTKVVRRSLIDLGRAIKGQVLMSSELEEVFNSMLVGKVPAMWAAKSYPSLKPLGGYVADLLARLTFFQEWIDKGPPVVFWISGFYFTQSFLTGVSQNYARKYTIPIDHIGFEFEVTPKETTMENIPEDGAYIKGLFLEGARWDRSTSQIGESLPKILYDPLPIIWLKPGESASFLHQDIYVCPVYKTSARRGILSTTGHSTNYVLSIELPTDMPQKHWINRGVASLCQLDN", "length": 4083 }, "evidence": [ { "id": "RGD:1305855", "url": "https://alliancegenome.org/gene/RGD:1305855#orthology", "database": "AGR" }, { "id": "HGNC:2949", "url": "https://alliancegenome.org/gene/HGNC:2949#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-091112-7", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-091112-7#orthology", "database": "AGR" }, { "id": "MGI:2683040", "url": "https://alliancegenome.org/gene/MGI:2683040#orthology", "database": "AGR" }, { "id": "FB:FBgn0035581", "url": "https://alliancegenome.org/gene/FB:FBgn0035581#orthology", "database": "AGR" }, { "id": "Q8TD57", "url": "https://omabrowser.org/oma/group/Q8TD57/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VZ77-1", "protein_name": "Dynein, axonemal, heavy chain 3, isoform D", "gene_name": "Dnah3", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MQKKVAPERRPYCDPRLQDDKLRRKRTLHLPRVSQAQKKGEKRQLNDCPFYNLTYGFDQLPLDPVKEFLQEKISHMQTDKIVGHCNREFDFHRYDLDNVKDEYDECDDDSLQELQLEDIIMPEQFEMLRDAKDHLYNFDSTACNQFPWIDKWMTGVRPSEQEIYEMTSHLLEIYCNRRVRIFYPGCGTSSSLWTNQLRRQHGSPSELIGAYRTPSARHMRVNNMRGPPKKEKFTAGDHYAFRTPQECRNELMRVGKIIDELIEPVLKAAEHKIGHGLTKYPDPPSCKDNTNRILRSAGILVGKKKNCYVGKCRIHRKDFATNEEFLRCLKRMEATHFPYMQPLQPVDPDDQKIKMLAKYRVELARAEKLFTLKIQKRYQCLLKSMSIVQLATYPSHLIRKAFRRINPRSALLQDAYQFIVKEKRDWPKLPPEVILMDYLFVGDRGVRQDLAILIIVCLIDLQEDFRHYVKRSFLNYLLSSNMERRRLQLEREPPEFPILTISPPVSWRSNLLRGKARIGEVLMTTHPTVQALNRLWHDLYEDLVVVDLGQLLLAQRPLDADTVQVFIEKSCADVRDLLLNDWLPRCADLMNEMRGTWKDLVPMSGKYGGRAAMLFRCIHSAMSRHLNSLISKSINYLFKVLCAFKGGNRIEKYSMFDAKLKRIPLMTLIASVVGAHFDHEPINMGPGVRPASNIYVYDEDDADPFQQPQVNQFVENVPDIDDVAQFELDHSNKLYIYPYMQELPRIFTEHFKSILAVGYEIPRLEFVMSGGEPETKGFLHFIDEDHVDFLELCEKVEQIVKVNWQGVHVYLKPVYKYYFGLFQKLILPMVQKVWTENNLPELGAVQELLKKLQAVSDTTYYLRDFIPLNLFMLDNRHVKLSLRMYVREIYDFIIDFYKALNWNENRAICEELEEMSMKAGERPEETPEVVALQNYINDCREMRIFAIKDEIKNVLKRVVFLLTHTYLSSDELHLNSRTFILPGELEEVLDLSAARLAVVRDNLELALRERRMEFEKLLAQEKRTMDGFRIREIRDVLTLEELKERVDTVDLLFTTIENLSREAKAINTEETLLQIDVSAFPLLAEIIEKMEPIEKLWKTSYEFEKDYLIWMFERFECLNADGVREQVENMHKIMYKLSRQLAYNPVAKRAAEQMRMKIEKFRVYLPVLDSICRHGLEKRHWDQISKILGRKVNPKLFPTLKDMIDVDIMSILPQLEEIANAAGKEYDLNNGLRIMQADWRDVMFEVLQYRDSDTHILASLDDIQTLLDDHIMRTQAMKRSPFITALGSKADDWEARLLLIQNIIDAWTQVQITWMYLEPIFSSEDIMRQMPLEGRNFKAVDKLWRKIMKHTLKDRHVMAATEYPEMLEVFTKAIEDLETVTKGLNTYLEQKRLFFARFFFLSNDELLEILSETKDPMRVQPHLRKCFEGIGSLTFDDNMEIVEMVSDEEERVALVRKINPQLANGLVEMWLKEVEMVMLDSVKEQMREAWEDYAMVERISWVVSWPGQVVQGISCMAWTYEVEEAIETKELPAYLEKSNLQIADLVQLVRTDLQAGVRIAVEALIVLDVHDRDVVKYLTDCRITNIQDFDWISQLRYYWKVNEKNEDWVCVSMVVTDVEYGMEYLGNLPRLVVTPLTDRCYRTLMGALKLCLGGAPEGPAGTGKTETCKDLAKAVAKKCVVFNCSDGLDYKALGKFFKGLAQSGAWACFDEFNRIELEVLSVVAQQILTIQRAIGRKVVKFFFEDTMLKLDPTCSIFITMNPGYAGRTELPDNLKVLFRTVAMMVPDYAMIGEITLYSNGFDMARNLSQKIVQAYKLCSEQLSSQSHYDYGMRAVKSVLLASASLRRLYVDLPEPEIVLRAIVDVNLPKFLEQDISLFIGIYMDLFPGVELPMPQRGDILKWLHINLADRNLQATPWYLEKILQIYEMLLVRHGLMIVGGSMGGKTTAYQVLAQTLRNVSTDEEATLKEFPVTFRIINPKAITMGQLYGRFDPVSHEWYDGVLAKTFREQVQGPKGERAWVMFDGPVDAVWIENLNTVLDDNKKLCLMSGEIMQMTKLMNMMFEPADLEQASPATVSRCGMIYMEPSQLGWRALHKSFINVLVNKVGLGDIYMTLFEDMTEWLVPAALEFLPQCKQMLELSPIYQYQTFSRFFLHFLEKHKQFNQAWFQQMFLFCFAWAYCSALTGQGQKTFDALLRKVIYGSNENFPKPKYFSLNRGQMFPEKLLFLDYRFDEAENWWTWQKSDDSASTTSNFPENAQISELIVPTKETGYISYWQEFCISKSYAMLVVGPTGTGKSAIITSNLLAMPKFANLVNVINFSARTSAQMVQDTIMSKLDRRRKGVFGPSLGKKCTVFCDDVAMPSKDTYGSQAPLELLRTWLDHGYWSDLVDTTKIELVDMTLMCAMGTLGGSNFIFPRLYRHMFVVAVDSFEDSTIVRIFTTIGDWHFSKGYPEKVALLSRGLSEAMVSVYRDAIRSFLPTPAKSHYSFSLRDITRVFQGIVMVPPKRMPDPEKLGRLWAHETYRVFYDRLVDQQDRDRLLVMAVDACKSNLRFPLEQAFGERIEPGEKLTDNDLRNLFYGNYMEPDAEPKFYDEGDTYEKLEKLMKYYLREYNSFSSTPMDLVMFRFAIEHVSRVSRVLQMPRGNILMVGMGGSGRRSSARLAAYIADCRLMTVQVSKSYTITDWRDDLKKILMSASFNLNHTVFLFSDAQATDEGYVEDINGILNTGDLPNLYQLEDKATIMENMANVAKQLGKILDTLPSEVYAYYIDRIREQLHIALAFSPIGDSFKERIRVYPSLINCCTIDWYMPWPEEALSRVGVYFVSSMNLNRPHGEETQEPVQSKDAADPDEEEVRRETVGVEREQTQLEADLVDCVMYFHQSVVDASEKCYLELNRRNYVTPSAYLELLKAFRTFYTRKLDEITRLRDRYTTGLEKLDFAAGQVGEMQTNLYDLQPKLKVLSEETDRIMVNIERETAEAEKKKEVVGADEAAANEAAAAAQAIKDDCETDLAEAIPAMEAALEALNTLKPADIFIVKSMKNPPYGVKLTMEAVCVIRGIKPDRKPDPSGHMVEDYWGPSMRMLSDMKFLDSLKTFDKDNIPPPIIKRIREKYIADRDFVPEKIKAASMACEGICRWVRAMDVYDKVARIVMPKKAALAEAEGELSQQMEKLNAKRAELQVILDKLQKLNDFFAEKSREKKRLEDEIDNCEKKLNRAEKLLGGLGGEKTRWSEAAKNLHESISNIVGDVLLAGGCTAYLGYFTTEYRVNILDDWNALCKRKHIPSSETFSLATTLGHPMTIRAWSLAGLPADNFSVENGIIVTNSSRYSLLIDPQVQANKWIKNMEKNNNLKVIKQSDANYMQVLELAITFGQPVLIENVGEKLDSNLTPILEKNVIKHKGGLFIKSGDQMIEYNPNFRLYITTCLRNPRYPPEVMVMVTVLNFMITEQGLREQLLAIVVAHERPDLQEKKEQLIIESARNRDALYTIESKILEVLSTSEGNVLEDENAINILSSSKILSEDIQEKQVIAVATEIEIDAARQQYIPVSKHSAILFFCISELANVDPMYQYSLSWFLNLFVNTILKAPKSDQLSERLKNLNDYFTKSIYTNVCRSLFEKDKLVISLVMCLGILVSQGRVEKAALLFFLTGGIGYKTIPPNPLGAWLPDKSWASVCKAADLEGLKNLPQMMETYSDEWHNFYDASNPDQLQLPAPHNTVNDMYFLIVIKSLRPDKLVPAVRAFITRNLDRSFVEPPPFDLAASFADSSPKIPLVFLLSAGSDPMASLFMFAKQRNMYDKLKTISLGQGQGPRAEKMIMEAARHGQWVVLQNCHVAISWMGDLERICNDTTLTDGANHDYRLWCTSYPSAVFPVSVLQNSVKMTNEPPKGLRANMHRSFTSDPLMRDKFFTNAFLFSDSANKCWLRGVFALVFFHAVVQERREFGPLGWNIPYEFNESDLKISLLQLKMFINQSQSIPFRGHVYLTGECNYGGRVTDDKDRRLILSLLNMIYNPNTIEEDNYALSQSGTYRVPLSPTRLNSIEYVSSFPLSPHPEVYGLHENADINRNVKETNALISGVLLTQTDLMASVKASSSGGAKEDPAIAICKQVLKQLPEEFNIDEVSKTYPVIYTNSMNTVLRQELIRFNRLLSYIRKSLVNVGKAVVGQIAMIPELERTHASMVIGKLPADWLKKSYPSLKPLGSYVSDLLARLAFFQEWIDNGEPMVYWISGFYFTQSFITGVLQNYSRKNRFQIDMILIEFAVTKFEVQVPGTPDIGAYIRGIFIEGARWNRKTKEVDESFSKVLFDTLPVIYLRPVLKALEDLPRSTAGGEPETIYDCPVYKTSERRGVLSTTGHSTNFVMYLQLRCSRKPMHWINRGTACLCQLDD", 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"UniProtKB", "id": "Q8TD57", "url": "https://www.uniprot.org/uniprotkb/Q8TD57" } ], "pmid": "" }, { "name": "sperm axoneme assembly", "id": "GO:0007288", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007288", "evidence": [ { "database": "UniProtKB", "id": "Q8TD57", "url": "https://www.uniprot.org/uniprotkb/Q8TD57" } ], "pmid": "" }, { "name": "inner dynein arm assembly", "id": "GO:0036159", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036159", "evidence": [ { "database": "UniProtKB", "id": "Q8TD57", "url": "https://www.uniprot.org/uniprotkb/Q8TD57" } ], "pmid": "" }, { "name": "cilium-dependent cell motility", "id": "GO:0060285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060285", "evidence": [ { "database": "UniProtKB", "id": "Q8TD57", "url": "https://www.uniprot.org/uniprotkb/Q8TD57" } ], "pmid": "" }, { "name": "cilium movement", "id": "GO:0003341", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003341", "evidence": [ { "database": "UniProtKB", "id": "Q8TD57", "url": "https://www.uniprot.org/uniprotkb/Q8TD57" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q8TD57", "url": "https://www.uniprot.org/uniprotkb/Q8TD57" } ], "pmid": "" }, { "name": "microtubule motor activity", "id": "GO:0003777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003777", "evidence": [ { "database": "UniProtKB", "id": "Q8TD57", "url": "https://www.uniprot.org/uniprotkb/Q8TD57" } ], "pmid": "" }, { "name": "minus-end-directed microtubule motor activity", "id": "GO:0008569", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008569", "evidence": [ { "database": "UniProtKB", "id": "Q8TD57", "url": "https://www.uniprot.org/uniprotkb/Q8TD57" } ], "pmid": "" }, { "name": "dynein light intermediate chain binding", "id": "GO:0051959", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051959", "evidence": [ { "database": "UniProtKB", "id": "Q8TD57", "url": "https://www.uniprot.org/uniprotkb/Q8TD57" } ], "pmid": "" }, { "name": "dynein intermediate chain binding", "id": "GO:0045505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045505", "evidence": [ { "database": "UniProtKB", "id": "Q8TD57", "url": "https://www.uniprot.org/uniprotkb/Q8TD57" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q8TD57", "url": "https://www.uniprot.org/uniprotkb/Q8TD57" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "Q8TD57", "url": "https://www.uniprot.org/uniprotkb/Q8TD57" } ], "pmid": "" }, { "name": "sperm flagellum", "id": "GO:0036126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "evidence": [ { "database": "UniProtKB", "id": "Q8TD57", "url": "https://www.uniprot.org/uniprotkb/Q8TD57" } ], "pmid": "" }, { "name": "axonemal dynein complex", "id": "GO:0005858", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005858", "evidence": [ { "database": "UniProtKB", "id": "Q8TD57", "url": "https://www.uniprot.org/uniprotkb/Q8TD57" } ], "pmid": "" }, { "name": "inner dynein arm", "id": "GO:0036156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036156", "evidence": [ { "database": "UniProtKB", "id": "Q8TD57", "url": "https://www.uniprot.org/uniprotkb/Q8TD57" } ], "pmid": "" }, { "name": "9+2 motile cilium", "id": "GO:0097729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097729", "evidence": [ { "database": "UniProtKB", "id": "Q8TD57", "url": "https://www.uniprot.org/uniprotkb/Q8TD57" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1017, "end_pos": 1019, "annotation": "n_glycosylation_sequon" }, { "start_pos": 113, "end_pos": 115, "annotation": 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