[ { "uniprot_canonical_ac": "Q8IVF2-1", "uniprot_ac": "Q8IVF2", "uniprot_id": "AHNK2_HUMAN", "mass": { "chemical_mass": 616629.0, "monoisotopic_mass": 616629.0 }, "refseq": { "ac": "NP_612429", "name": "protein AHNAK2 isoform 1", "summary": "This gene encodes a large nucleoprotein. The encoded protein has a tripartite domain structure with a relatively short N-terminus and a long C-terminus, separated by a large body of repeats. The N-terminal PSD-95/Discs-large/ZO-1 (PDZ)-like domain is thought to function in the formation of stable homodimers. The encoded protein may play a role in calcium signaling by associating with calcium channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612429" }, "gene_names": [ { "name": "AHNAK2", "type": "recommended", "evidence": [ { "id": "Q8IVF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8IVF2" } ] }, { "name": "AHNAK2", "type": "synonym", "evidence": [ { "id": "NP_612429", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612429" } ] }, { "name": "C14orf78", "type": "synonym", "evidence": [ { "id": "NP_612429", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612429" }, { "id": "Q8IVF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8IVF2" } ] }, { "name": "KIAA2019", "type": "synonym", "evidence": [ { "id": "Q8IVF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8IVF2" } ] } ], "protein_names": [ { "name": "Protein AHNAK2", "type": "recommended", "evidence": [ { "id": "Q8IVF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8IVF2/entry#names_and_taxonomy" } ] }, { "name": "protein AHNAK2 isoform 1", "type": "synonym", "evidence": [ { "id": "NP_612429", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612429" } ] }, { "name": "protein AHNAK2", "type": "synonym", "evidence": [ { "id": "NP_612429", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612429" } ] } ], "function": [ { "annotation": "AHNAK2 Promotes the Progression of Differentiated Thyroid Cancer through PI3K/AKT Signaling Pathway.", "evidence": [ { "database": "RefSeq", "id": "NP_612429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612429" }, { "database": "PubMed", "id": "36089788", "url": "https://glygen.org/publication/PubMed/36089788" } ] }, { "annotation": "AHNAK2 is a novel prognostic marker and correlates with immune infiltration in papillary thyroid cancer: Evidence from integrated analysis.", "evidence": [ { "database": "RefSeq", "id": "NP_612429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612429" }, { "database": "PubMed", "id": "33218938", "url": "https://glygen.org/publication/PubMed/33218938" } ] }, { "annotation": "AHNAK2 promotes thyroid carcinoma progression by activating the NF-kappaB pathway.", "evidence": [ { "database": "RefSeq", "id": "NP_612429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612429" }, { "database": "PubMed", "id": "34627772", "url": "https://glygen.org/publication/PubMed/34627772" } ] }, { "annotation": "Downregulation of AHNAK2 inhibits cell cycle of lung adenocarcinoma cells by interacting with RUVBL1.", "evidence": [ { "database": "RefSeq", "id": "NP_612429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612429" }, { "database": "PubMed", "id": "37349884", "url": "https://glygen.org/publication/PubMed/37349884" } ] }, { "annotation": "Periaxin and AHNAK nucleoprotein 2 form intertwined homodimers through domain swapping", "evidence": [ { "database": "RefSeq", "id": "NP_612429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612429" }, { "database": "PubMed", "id": "24675079", "url": "https://glygen.org/publication/PubMed/24675079" } ] }, { "annotation": "Silencing of AHNAK2 restricts thyroid carcinoma progression by inhibiting the Wnt/beta-catenin pathway.", "evidence": [ { "database": "RefSeq", "id": "NP_612429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612429" }, { "database": "PubMed", "id": "34374294", "url": "https://glygen.org/publication/PubMed/34374294" } ] }, { "annotation": "This gene encodes a large nucleoprotein. The encoded protein has a tripartite domain structure with a relatively short N-terminus and a long C-terminus, separated by a large body of repeats. The N-terminal PSD-95/Discs-large/ZO-1 (PDZ)-like domain is thought to function in the formation of stable homodimers. The encoded protein may play a role in calcium signaling by associating with calcium channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017].", "evidence": [ { "database": "RefSeq", "id": "NP_612429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612429" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "61.34", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000185567", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000185567" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "92.75", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000185567", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000185567" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "86.79", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000185567", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000185567" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "85.74", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000185567", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000185567" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "97.23", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000185567", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000185567" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "81.44", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000185567", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000185567" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "72.18", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000185567", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000185567" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "87.06", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000185567", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000185567" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "69.2", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000185567", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000185567" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "59.04", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000185567", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000185567" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "62.39", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000185567", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000185567" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "84.34", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000185567", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000185567" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "80.54", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000185567", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000185567" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "Q8IVF2", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q8IVF2" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "Q8IVF2", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q8IVF2" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Urinary bladder cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "Q8IVF2", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q8IVF2" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "11054", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11054" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Head and neck cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "Q8IVF2", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q8IVF2" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ], "unlinked_id_list": [ "DOID:1542" ], "evidence": [ { "id": "11934", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11934" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Lung cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "Q8IVF2", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q8IVF2" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", 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"url": "https://oglcnac.org/atlas/detail/Q8IVF2", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "KDTKFKM", "url": "https://omabrowser.org/oma/group/KDTKFKM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q8IVF2", "url": "https://www.orthodb.org/?gene=Q8IVF2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23348", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23348", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23348:SF37", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23348:SF37", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00004cn0", "url": "https://www.rcsb.org/structure/pdb_00004cn0", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4CN0", "url": "https://www.rcsb.org/structure/4CN0", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "Q8IVF2", "url": "https://pharos.nih.gov/targets/Q8IVF2", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR:Q8IVF2", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:Q8IVF2", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_612429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612429", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q8IVF2", "url": "https://www.uniprot.org/uniprotkb/Q8IVF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8IVF2-1", "url": "https://www.uniprot.org/uniprotkb/Q8IVF2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8IVF2-2", "url": "https://www.uniprot.org/uniprotkb/Q8IVF2-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8IVF2-3", "url": "https://www.uniprot.org/uniprotkb/Q8IVF2-3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCDCFHMVLPTWPGTPGSVSGRQLQPGEPGAETEDDHSVTEGPADEGIRPRPQGSSPVYEYTTEAADFGLQEDAPGRQGSAGRRRSWWKRDSGDSRTFFRMSRPEAVQEATEVTLKTEVEAGASGYSVTGGGDQGIFVKQVLKDSSAAKLFNLREGDQLLSTTVFFENIKYEDALKILQYSEPYKVQFKIRRQLPAPQDEEWASSDAQHGPQGKEKEDTDVADGCRETPTKTLEGDGDQERLISKPRVGRGRQSQRERLSWPKFQSIKSKRGPGPQRSHSSSEAYEPRDAHDVSPTSTDTEAQLTVERQEQKAGPGSQRRRKFLNLRFRTGSGQGPSSTGQPGRGFQSGVGRAGVLEELGPWGDSLEETGAATGSRREERAEQDREVMPAQSMPLPTELGDPRLCEGTPQEGGLRAARLHGKTLEGQAQETAVAQRKPRAQPTPGMSREGEGEGLQSLEIGIARLSLRDTTEGGTQIGPPEIRVRVHDLKTPKFAFSTEKEPERERRLSTPQRGKRQDASSKAGTGLKGEEVEGAGWMPGREPTTHAEAQGDEGDGEEGLQRTRITEEQDKGREDTEGQIRMPKFKIPSLGWSPSKHTKTGREKATEDTEQGREGEATATADRREQRRTEEGLKDKEDSDSMTNTTKIQLIHDEKRLKKEQILTEKEVATKDSKFKMPKFKMPLFGASAPGKSMEASVDVSAPKVEADVSLLSMQGDLKTTDLSVQTPSADLEVQDGQVDVKLPEGPLPEGASLKGHLPKVQRPSLKMPKVDLKGPKLDLKGPKAEVTAPDVKMSLSSMEVDVQAPRAKLDGARLEGDLSLADKEVTAKDSKFKMPKFKMPSFGVSAPGKSMEDSVDVSAPKVEADVSLSSMQGDLKATDLSIQPPSADLEVQAGQVDVKLPEGPVPEGAGPKVHLPKVEMPSFKMPKVDLKGPQIDVKGPKLDLKGPKAEVTAPDGEVSLPSMEVDVQAQKAKLDGAWLEGDLSLADKDVTAKDSKFKMPKFKMPSFGVSAPGKSIKALVDVSAPKVEADLSLPSMQGDLKTTDLSIQPASTDLKVQADQVDVKLPEGHLPEGAGLKGHLPKVEMPSFKMPKVALKGPQVDVKGPKLDLKSPKAEVTAPDVEVSLPSVEVDVEAPGAKLDSARLEGELSLADKDVTAKDSRFKMPKFKMPSFGASAPGKSIEASVDVSAPKVEADVSLPSMQGDLKTTDLSIQPPSADLEVHAGQVDVKLLEGHVPEGAGFKGHLPKVQMPSLKMPKVDLKGPQVEVRGPKLDLKGHKAEVTAHEVAVSLPSVEVDMQAPGAKLDGAQLDGDLSLADKDVTAKDSKFKMPKFKMPSFGVSAPGKSIEASVDLSAPKVEADMSLPSMQGDLKTTDLSIQPPSTDLELQAGQLDVKLPEGPVPEGAGLKGHLPKLQMPSFKVPKVDLKGPEIDIKGPKLDLKDPKVEVTAPDVEVSLPSVEVDVEAPGAKLDGGRLEEDMSLADKDLTTKDSKFKMPKFKMPSFGVSAPGKSIEASVDVSAPKVEADVSLPSMQGDLKATDLSIQPPSADLEVQAGQVDVKLPEGPVSEGAGLKGHLPKVQMPSFKMPKVDLKGPQIDVKGPKLDLKGPKVEVTAPDVKMSLSSMEVDVQAPRAKLDGAQLEGDLSLADKAVTAKDSKFKMPKFKMPSFGVSAPGKSIEASVDVSEPKVEADVSLPSMQGDLKTTDLSIQSPSADLEVQAGQVNVKLPEGPLPEGAGFKGHLPKVQMPSLKMPKVALKGPQMDVKGPKLDLKGPKAEVMAPDVEVSLPSVEVDVEAPGAKLDSVRLEGDLSLADKDVTAKDSKFKMPKFKMPSFGVSAPGKSIEASVDVSAPKVEAEVSLPSMQGDLKTTDLCIPLPSADLVVQAGQVDMKLPEGQVPEGAGLKGHLPKVDMPSFKMPKVDLKGPQTDVKGAKLDLKGPKAEVTAPDVEVSLPSMEVDVQAQKAKLDGARLEGDLSLADKDMTAKDSKFKMPKFKMPSFGVSAPGRSIEASVDVPAPKVEADVSLPSMQGDLKTTDLSIQPPSADLKVQTGQVDVKLPEGHVPEGAGLKGHLPKVEMPSLKMPKVDLKGPQVDIKGPKLDLKDPKVEMRVPDVEVSLPSMEVDVQAPRAKLDSAHLQGDLTLANKDLTTKDSKFKMPKFKMPSFGVSAPGKSIEASVDVSPPKVEADMSLPSMQGDLKTTDLSIQPLSADVKVQAGQVDVKLLEGPVPEEVGLKGHLPKLQMPSFKVPKVDLKGPEIDIKGPKLDLKDPKVEVTAPDVEVSLPSVEVDVKAPGAKLDGARLEGDMSLADKDVTAKDSKFKMPKFKMLSFGVSALGKSIEASADVSALKVEADVSLPSMQGDLKTTDLSVQPPSADLEVQAGQVDVKLPEGPVPEGAGLKGHLPKLQMPSFKMPKVDLKGPQIDVKGPKLDLKGPKTDVMAPDVEVSQPSVEVDVEAPGAKLDGAWLEGDLSVADKDVTTKDSRFKIPKFKMPSFGVSAPGKSIEASVDVSAPKVEADGSLSSMQGDLKATDLSIQPPSADLEVQAGQVDVKLPEGPVPEGAGLKGHLPKVQMPSFKMPEMDLKGPQLDVKGPKLDLKGPKAEVTAPDVEMSLSSMEVDVQAPRAKLDGARLEGDLSLADKGVTAKDSKFKMPKFKMPSFRVSAPGESIEALVDVSELKVEADMSLPSMQGDLKTTDISIQPPSAQLEVQAGQVDVKLPEGHVPEGAGLKGHLPKLQMPSFKMPEVDLKGPQIDVKGPNVDLKGPKAEVTAPDVKMSLSSMEVDVQAPRAKLDGARLEGDLSLADKGMTAKDSKFKMPKFKMPSFGVSAPGKSIEASVDVSELKVEADGSFPSMQGDLKTTDIRIQPPSAQLEVQAGQVDVKLPEGHVPEGAGLKGHLPKVQMPSFKMPKVDLKGPQIDVKGPKLDLKGPKAEVTAPDVEVSLPSVEVDVEAPRAKLDGARLEGDLSLADKDVTAKDSKFKMPKFKMPSFGVSAPGKSIEVSVDVSAPKVEAEVSLPSMQGDLKTTDISIEPPSAQLEVQAGQVDLKLPEGHVPEGAGLKGHLPKLQMPSFKMPKVDRKGPQIDVKGPKLDLKGPKTDVTAPDVEVSQPGMEVDVEAPGAKLDGARLEGDLSLADKDVTAKDSKFKMPKFKMPSFGVSAPGKSIEVLVDVSAPKVEADLSLPSMQGDLKNTDISIEPPSAQLEVQAGQVDVKLPEGHVLEGAGLKGHLPKLQMPSFKMPKVDRKGPQIDIKGPKLDLKGPKMDVTAPDVEVSQPSMEVDVEAPGAKLDGARLEGDLSLADKDVTAKDSKFKMPKFKMPSYRASAPGKSIQASVDVSAPKAEADVSLPSMQGDLKTTDLSIQLPSVDLEVQAGQVDVKLPEGHVPEGAGLKGHLPKVEMPSFKMPKVDLKSPQVDIKGPKLDLKVPKAEVTVPDVEVSLPSVEVDVQAPRAKLDGARLEGDLSLAEKDVTAKDSKFKMPKFKMPSFGVSAPGRSIEASLDVSAPKVEADVSLSSMQGDLKATDLSIQPPSADLEVQAVQVDVELLEGPVPEGAGLKGHLPKVEMPSLKTPKVDLKGPQIDVKGPKLDLKGPKAEVRVPDVEVSLPSVEVDVQAPKAKLDAGRLEGDLSLADKDVTAKDSKFKMPKFKMPSFRVSAPGKSMEASVDVSAPKVEADVSLPSMQGDLKTTDLSIQPPSADLKVQAGQMDVKLPEGQVPEGAGLKEHLPKVEMPSLKMPKVDLKGPQVDIKGPKLDLKVSKAEVTAPDVEVSLPSVEVDVQAPRAKLDSAQLEGDLSLADKDVTAKDSKFKMPKFKMPSFGVSAPGKSIEASVHVSAPKVEADVSLPSMQGDLKTTDLSIQPHSADLTVQARQVDMKLLEGHVPEEAGLKGHLPKVQMPSFKMPKVDLKGPEIDIKGPKLDLKDPKVEVTAPDVEVSLPSVEVDVEAPGAKLDGARLEGDLSLADKDMTAKDSKFKMPKFKMPSFGVSAPGKSMEASVDVTAPKVEADVSLPSMQGDLKATDLSVQPPSADLEVQAGQVDVKLPEGPVPEGASLKGHLPKVQMPSFKMPKVDLKGPQIDVKGPKLDLKGPKAEVTAPDVKMSLSSMEVDVQAPRAKLDGVQLEGDLSLADKDVTAKDSKFKMPKFKMPSFGVSAPGKSMEASVDVSELKAKADVSLPSMQGDLKTTDLSIQSPSADLEVQAGQVDVKLPEGPLPKGAGLKGHLPKVQMPCLKMPKVALKGPQVDVKGPKLDLKGPKADVMTPVVEVSLPSMEVDVEAPGAKLDSVRLEGDLSLADKDMTAKDSKFKMPKFKMPSFGVSAPGKSIEASLDVSALKVEADVSLPSMQGDLKTTHLSIQPPSADLEVQAGQEDVKLPEGPVHEGAGLKGHLPKLQMPSFKVPKVDLKGPQIDVNVPKLDLKGPKVEVTSPNLDVSLPSMEVDIQAPGAKLDSTRLEGDLSLADKDVTAKDSKFKMPKFKMPSFGMLSPGKSIEVSVDVSAPKMEADMSIPSMQGDLKTTDLRIQAPSADLEVQAGQVDLKLPEGHMPEVAGLKGHLPKVEMPSFKMPKVDLKGPQVDVKGPKLDLKGPKAEVMAPDVEVSLPSVETDVQAPGSMLDGARLEGDLSLAHEDVAGKDSKFQGPKLSTSGFEWSSKKVSMSSSEIEGNVTFHEKTSTFPIVESVVHEGDLHDPSRDGNLGLAVGEVGMDSKFKKLHFKVPKVSFSSTKTPKDSLVPGAKSSIGLSTIPLSSSECSSFELQQVSACSEPSMQMPKVGFAGFPSSRLDLTGPHFESSILSPCEDVTLTKYQVTVPRAALAPELALEIPSGSQADIPLPKTECSTDLQPPEGVPTSQAESHSGPLNSMIPVSLGQVSFPKFYKPKFVFSVPQMAVPEGDLHAAVGAPVMSPLSPGERVQCPLPSTQLPSPGTCVSQGPEELVASLQTSVVAPGEAPSEDADHEGKGSPLKMPKIKLPSFRWSPKKETGPKVDPECSVEDSKLSLVLDKDEVAPQSAIHMDLPPERDGEKGRSTKPGFAMPKLALPKMKASKSGVSLPQRDVDPSLSSATAGGSFQDTEKASSDGGRGGLGATASATGSEGVNLHRPQVHIPSLGFAKPDLRSSKAKVEVSQPEADLPLPKHDLSTEGDSRGCGLGDVPVSQPCGEGIAPTPEDPLQPSCRKPDAEVLTVESPEEEAMTKYSQESWFKMPKFRMPSLRRSFRDRGGAGKLEVAQTQAPAATGGEAAAKVKEFLVSGSNVEAAMSLQLPEADAEVTASESKSSTDILRCDLDSTGLKLHLSTAGMTGDELSTSEVRIHPSKGPLPFQMPGMRLPETQVLPGEIDETPLSKPGHDLASMEDKTEKWSSQPEGPLKLKASSTDMPSQISVVNVDQLWEDSVLTVKFPKLMVPRFSFPAPSSEDDVFIPTVREVQCPEANIDTALCKESPGLWGASILKAGAGVPGEQPVDLNLPLEAPPISKVRVHIQGAQVESQEVTIHSIVTPEFVDLSVPRTFSTQIVRESEIPTSEIQTPSYGFSLLKVKIPEPHTQARVYTTMTQHSRTQEGTEEAPIQATPGVDSISGDLQPDTGEPFEMISSSVNVLGQQTLTFEVPSGHQLADSCSDEEPAEILEFPPDDSQEATTPLADEGRAPKDKPESKKSGLLWFWLPNIGFSSSVDETGVDSKNDVQRSAPIQTQPEARPEAELPKKQEKAGWFRFPKLGFSSSPTKKSKSTEDGAELEEQKLQEETITFFDARESFSPEEKEEGELIGPVGTGLDSRVMVTSAARTELILPEQDRKADDESKGSGLGPNEG", "length": 5795, "header": "sp|Q8IVF2-1|AHNK2_HUMAN Isoform 1 of Protein AHNAK2 OS=Homo sapiens OX=9606 GN=AHNAK2 PE=1 SV=2 CANONICAL=Q8IVF2-1" }, "isoforms": [ { "isoform_ac": "Q8IVF2-1", "url": "https://www.uniprot.org/uniprotkb/Q8IVF2/entry#Q8IVF2-1", "sequence": { "sequence": "MCDCFHMVLPTWPGTPGSVSGRQLQPGEPGAETEDDHSVTEGPADEGIRPRPQGSSPVYEYTTEAADFGLQEDAPGRQGSAGRRRSWWKRDSGDSRTFFRMSRPEAVQEATEVTLKTEVEAGASGYSVTGGGDQGIFVKQVLKDSSAAKLFNLREGDQLLSTTVFFENIKYEDALKILQYSEPYKVQFKIRRQLPAPQDEEWASSDAQHGPQGKEKEDTDVADGCRETPTKTLEGDGDQERLISKPRVGRGRQSQRERLSWPKFQSIKSKRGPGPQRSHSSSEAYEPRDAHDVSPTSTDTEAQLTVERQEQKAGPGSQRRRKFLNLRFRTGSGQGPSSTGQPGRGFQSGVGRAGVLEELGPWGDSLEETGAATGSRREERAEQDREVMPAQSMPLPTELGDPRLCEGTPQEGGLRAARLHGKTLEGQAQETAVAQRKPRAQPTPGMSREGEGEGLQSLEIGIARLSLRDTTEGGTQIGPPEIRVRVHDLKTPKFAFSTEKEPERERRLSTPQRGKRQDASSKAGTGLKGEEVEGAGWMPGREPTTHAEAQGDEGDGEEGLQRTRITEEQDKGREDTEGQIRMPKFKIPSLGWSPSKHTKTGREKATEDTEQGREGEATATADRREQRRTEEGLKDKEDSDSMTNTTKIQLIHDEKRLKKEQILTEKEVATKDSKFKMPKFKMPLFGASAPGKSMEASVDVSAPKVEADVSLLSMQGDLKTTDLSVQTPSADLEVQDGQVDVKLPEGPLPEGASLKGHLPKVQRPSLKMPKVDLKGPKLDLKGPKAEVTAPDVKMSLSSMEVDVQAPRAKLDGARLEGDLSLADKEVTAKDSKFKMPKFKMPSFGVSAPGKSMEDSVDVSAPKVEADVSLSSMQGDLKATDLSIQPPSADLEVQAGQVDVKLPEGPVPEGAGPKVHLPKVEMPSFKMPKVDLKGPQIDVKGPKLDLKGPKAEVTAPDGEVSLPSMEVDVQAQKAKLDGAWLEGDLSLADKDVTAKDSKFKMPKFKMPSFGVSAPGKSIKALVDVSAPKVEADLSLPSMQGDLKTTDLSIQPASTDLKVQADQVDVKLPEGHLPEGAGLKGHLPKVEMPSFKMPKVALKGPQVDVKGPKLDLKSPKAEVTAPDVEVSLPSVEVDVEAPGAKLDSARLEGELSLADKDVTAKDSRFKMPKFKMPSFGASAPGKSIEASVDVSAPKVEADVSLPSMQGDLKTTDLSIQPPSADLEVHAGQVDVKLLEGHVPEGAGFKGHLPKVQMPSLKMPKVDLKGPQVEVRGPKLDLKGHKAEVTAHEVAVSLPSVEVDMQAPGAKLDGAQLDGDLSLADKDVTAKDSKFKMPKFKMPSFGVSAPGKSIEASVDLSAPKVEADMSLPSMQGDLKTTDLSIQPPSTDLELQAGQLDVKLPEGPVPEGAGLKGHLPKLQMPSFKVPKVDLKGPEIDIKGPKLDLKDPKVEVTAPDVEVSLPSVEVDVEAPGAKLDGGRLEEDMSLADKDLTTKDSKFKMPKFKMPSFGVSAPGKSIEASVDVSAPKVEADVSLPSMQGDLKATDLSIQPPSADLEVQAGQVDVKLPEGPVSEGAGLKGHLPKVQMPSFKMPKVDLKGPQIDVKGPKLDLKGPKVEVTAPDVKMSLSSMEVDVQAPRAKLDGAQLEGDLSLADKAVTAKDSKFKMPKFKMPSFGVSAPGKSIEASVDVSEPKVEADVSLPSMQGDLKTTDLSIQSPSADLEVQAGQVNVKLPEGPLPEGAGFKGHLPKVQMPSLKMPKVALKGPQMDVKGPKLDLKGPKAEVMAPDVEVSLPSVEVDVEAPGAKLDSVRLEGDLSLADKDVTAKDSKFKMPKFKMPSFGVSAPGKSIEASVDVSAPKVEAEVSLPSMQGDLKTTDLCIPLPSADLVVQAGQVDMKLPEGQVPEGAGLKGHLPKVDMPSFKMPKVDLKGPQTDVKGAKLDLKGPKAEVTAPDVEVSLPSMEVDVQAQKAKLDGARLEGDLSLADKDMTAKDSKFKMPKFKMPSFGVSAPGRSIEASVDVPAPKVEADVSLPSMQGDLKTTDLSIQPPSADLKVQTGQVDVKLPEGHVPEGAGLKGHLPKVEMPSLKMPKVDLKGPQVDIKGPKLDLKDPKVEMRVPDVEVSLPSMEVDVQAPRAKLDSAHLQGDLTLANKDLTTKDSKFKMPKFKMPSFGVSAPGKSIEASVDVSPPKVEADMSLPSMQGDLKTTDLSIQPLSADVKVQAGQVDVKLLEGPVPEEVGLKGHLPKLQMPSFKVPKVDLKGPEIDIKGPKLDLKDPKVEVTAPDVEVSLPSVEVDVKAPGAKLDGARLEGDMSLADKDVTAKDSKFKMPKFKMLSFGVSALGKSIEASADVSALKVEADVSLPSMQGDLKTTDLSVQPPSADLEVQAGQVDVKLPEGPVPEGAGLKGHLPKLQMPSFKMPKVDLKGPQIDVKGPKLDLKGPKTDVMAPDVEVSQPSVEVDVEAPGAKLDGAWLEGDLSVADKDVTTKDSRFKIPKFKMPSFGVSAPGKSIEASVDVSAPKVEADGSLSSMQGDLKATDLSIQPPSADLEVQAGQVDVKLPEGPVPEGAGLKGHLPKVQMPSFKMPEMDLKGPQLDVKGPKLDLKGPKAEVTAPDVEMSLSSMEVDVQAPRAKLDGARLEGDLSLADKGVTAKDSKFKMPKFKMPSFRVSAPGESIEALVDVSELKVEADMSLPSMQGDLKTTDISIQPPSAQLEVQAGQVDVKLPEGHVPEGAGLKGHLPKLQMPSFKMPEVDLKGPQIDVKGPNVDLKGPKAEVTAPDVKMSLSSMEVDVQAPRAKLDGARLEGDLSLADKGMTAKDSKFKMPKFKMPSFGVSAPGKSIEASVDVSELKVEADGSFPSMQGDLKTTDIRIQPPSAQLEVQAGQVDVKLPEGHVPEGAGLKGHLPKVQMPSFKMPKVDLKGPQIDVKGPKLDLKGPKAEVTAPDVEVSLPSVEVDVEAPRAKLDGARLEGDLSLADKDVTAKDSKFKMPKFKMPSFGVSAPGKSIEVSVDVSAPKVEAEVSLPSMQGDLKTTDISIEPPSAQLEVQAGQVDLKLPEGHVPEGAGLKGHLPKLQMPSFKMPKVDRKGPQIDVKGPKLDLKGPKTDVTAPDVEVSQPGMEVDVEAPGAKLDGARLEGDLSLADKDVTAKDSKFKMPKFKMPSFGVSAPGKSIEVLVDVSAPKVEADLSLPSMQGDLKNTDISIEPPSAQLEVQAGQVDVKLPEGHVLEGAGLKGHLPKLQMPSFKMPKVDRKGPQIDIKGPKLDLKGPKMDVTAPDVEVSQPSMEVDVEAPGAKLDGARLEGDLSLADKDVTAKDSKFKMPKFKMPSYRASAPGKSIQASVDVSAPKAEADVSLPSMQGDLKTTDLSIQLPSVDLEVQAGQVDVKLPEGHVPEGAGLKGHLPKVEMPSFKMPKVDLKSPQVDIKGPKLDLKVPKAEVTVPDVEVSLPSVEVDVQAPRAKLDGARLEGDLSLAEKDVTAKDSKFKMPKFKMPSFGVSAPGRSIEASLDVSAPKVEADVSLSSMQGDLKATDLSIQPPSADLEVQAVQVDVELLEGPVPEGAGLKGHLPKVEMPSLKTPKVDLKGPQIDVKGPKLDLKGPKAEVRVPDVEVSLPSVEVDVQAPKAKLDAGRLEGDLSLADKDVTAKDSKFKMPKFKMPSFRVSAPGKSMEASVDVSAPKVEADVSLPSMQGDLKTTDLSIQPPSADLKVQAGQMDVKLPEGQVPEGAGLKEHLPKVEMPSLKMPKVDLKGPQVDIKGPKLDLKVSKAEVTAPDVEVSLPSVEVDVQAPRAKLDSAQLEGDLSLADKDVTAKDSKFKMPKFKMPSFGVSAPGKSIEASVHVSAPKVEADVSLPSMQGDLKTTDLSIQPHSADLTVQARQVDMKLLEGHVPEEAGLKGHLPKVQMPSFKMPKVDLKGPEIDIKGPKLDLKDPKVEVTAPDVEVSLPSVEVDVEAPGAKLDGARLEGDLSLADKDMTAKDSKFKMPKFKMPSFGVSAPGKSMEASVDVTAPKVEADVSLPSMQGDLKATDLSVQPPSADLEVQAGQVDVKLPEGPVPEGASLKGHLPKVQMPSFKMPKVDLKGPQIDVKGPKLDLKGPKAEVTAPDVKMSLSSMEVDVQAPRAKLDGVQLEGDLSLADKDVTAKDSKFKMPKFKMPSFGVSAPGKSMEASVDVSELKAKADVSLPSMQGDLKTTDLSIQSPSADLEVQAGQVDVKLPEGPLPKGAGLKGHLPKVQMPCLKMPKVALKGPQVDVKGPKLDLKGPKADVMTPVVEVSLPSMEVDVEAPGAKLDSVRLEGDLSLADKDMTAKDSKFKMPKFKMPSFGVSAPGKSIEASLDVSALKVEADVSLPSMQGDLKTTHLSIQPPSADLEVQAGQEDVKLPEGPVHEGAGLKGHLPKLQMPSFKVPKVDLKGPQIDVNVPKLDLKGPKVEVTSPNLDVSLPSMEVDIQAPGAKLDSTRLEGDLSLADKDVTAKDSKFKMPKFKMPSFGMLSPGKSIEVSVDVSAPKMEADMSIPSMQGDLKTTDLRIQAPSADLEVQAGQVDLKLPEGHMPEVAGLKGHLPKVEMPSFKMPKVDLKGPQVDVKGPKLDLKGPKAEVMAPDVEVSLPSVETDVQAPGSMLDGARLEGDLSLAHEDVAGKDSKFQGPKLSTSGFEWSSKKVSMSSSEIEGNVTFHEKTSTFPIVESVVHEGDLHDPSRDGNLGLAVGEVGMDSKFKKLHFKVPKVSFSSTKTPKDSLVPGAKSSIGLSTIPLSSSECSSFELQQVSACSEPSMQMPKVGFAGFPSSRLDLTGPHFESSILSPCEDVTLTKYQVTVPRAALAPELALEIPSGSQADIPLPKTECSTDLQPPEGVPTSQAESHSGPLNSMIPVSLGQVSFPKFYKPKFVFSVPQMAVPEGDLHAAVGAPVMSPLSPGERVQCPLPSTQLPSPGTCVSQGPEELVASLQTSVVAPGEAPSEDADHEGKGSPLKMPKIKLPSFRWSPKKETGPKVDPECSVEDSKLSLVLDKDEVAPQSAIHMDLPPERDGEKGRSTKPGFAMPKLALPKMKASKSGVSLPQRDVDPSLSSATAGGSFQDTEKASSDGGRGGLGATASATGSEGVNLHRPQVHIPSLGFAKPDLRSSKAKVEVSQPEADLPLPKHDLSTEGDSRGCGLGDVPVSQPCGEGIAPTPEDPLQPSCRKPDAEVLTVESPEEEAMTKYSQESWFKMPKFRMPSLRRSFRDRGGAGKLEVAQTQAPAATGGEAAAKVKEFLVSGSNVEAAMSLQLPEADAEVTASESKSSTDILRCDLDSTGLKLHLSTAGMTGDELSTSEVRIHPSKGPLPFQMPGMRLPETQVLPGEIDETPLSKPGHDLASMEDKTEKWSSQPEGPLKLKASSTDMPSQISVVNVDQLWEDSVLTVKFPKLMVPRFSFPAPSSEDDVFIPTVREVQCPEANIDTALCKESPGLWGASILKAGAGVPGEQPVDLNLPLEAPPISKVRVHIQGAQVESQEVTIHSIVTPEFVDLSVPRTFSTQIVRESEIPTSEIQTPSYGFSLLKVKIPEPHTQARVYTTMTQHSRTQEGTEEAPIQATPGVDSISGDLQPDTGEPFEMISSSVNVLGQQTLTFEVPSGHQLADSCSDEEPAEILEFPPDDSQEATTPLADEGRAPKDKPESKKSGLLWFWLPNIGFSSSVDETGVDSKNDVQRSAPIQTQPEARPEAELPKKQEKAGWFRFPKLGFSSSPTKKSKSTEDGAELEEQKLQEETITFFDARESFSPEEKEEGELIGPVGTGLDSRVMVTSAARTELILPEQDRKADDESKGSGLGPNEG", "length": 5795, "header": "sp|Q8IVF2-1|AHNK2_HUMAN Isoform 1 of Protein AHNAK2 OS=Homo sapiens OX=9606 GN=AHNAK2 PE=1 SV=2 CANONICAL=Q8IVF2-1" }, "locus": { "chromosome": "14", "start_pos": 104978237, "end_pos": 104938066, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000333244.6", "url": "https://www.ensembl.org/id/ENST00000333244.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000353114.4", "url": "https://www.ensembl.org/id/ENSP00000353114.4" } ] } }, { "isoform_ac": "Q8IVF2-2", "url": "https://www.uniprot.org/uniprotkb/Q8IVF2/entry#Q8IVF2-2", "sequence": { "sequence": "MDLPPERDGEKGRSTKPGFAMPKLALPKMKASKSGVSLPQRDVDPSLSSATAGGSFQDTEKASSDGGRGGLGATASATGSEGVNLHRPQVHIPSLGFAKPDLRSSKAKVEVSQPEADLPLPKHDLSTEGDSRGCGLGDVPVSQPCGEGIAPTPEDPLQPSCRKPDAEVLTVESPEEEAMTKYSQESWFKMPKFRMPSLRRSFRDRGGAGKLEVAQTQAPAATGGEAAAKVKEFLVSGSNVEAAMSLQLPEADAEVTASESKSSTDILRCDLDSTGLKLHLSTAGMTGDELSTSEVRIHPSKGPLPFQMPGMRLPETQVLPGEIDETPLSKPGHDLASMEDKTEKWSSQPEGPLKLKASSTDMPSQISVVNVDQLWEDSVLTVKFPKLMVPRFSFPAPSSEDDVFIPTVREVQCPEANIDTALCKESPGLWGASILKAGAGVPGEQPVDLNLPLEAPPISKVRVHIQGAQVESQEVTIHSIVTPEFVDLSVPRTFSTQIVRESEIPTSEIQTPSYGFSLLKVKIPEPHTQARVYTTMTQHSRTQEGTEEAPIQATPGVDSISGDLQPDTGEPFEMISSSVNVLGQQTLTFEVPSGHQLADSCSDEEPAEILEFPPDDSQEATTPLADEGRAPKDKPESKKSGLLWFWLPNIGFSSSVDETGVDSKNDVQRSAPIQTQPEARPEAELPKKQEKAGWFRFPKLGFSSSPTKKSKSTEDGAELEEQKLQEETITFFDARESFSPEEKEEGELIGPVGTGLDSRVMVTSAARTELILPEQDRKADDESKGSGLGPNEG", "length": 793, "header": "sp|Q8IVF2-2|AHNK2_HUMAN Isoform 2 of Protein AHNAK2 OS=Homo sapiens OX=9606 GN=AHNAK2 PE=1 SV=2 CANONICAL=Q8IVF2-1" }, "locus": { "chromosome": "14", "start_pos": 104940444, "end_pos": 104938066, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000557457.1", "url": "https://www.ensembl.org/id/ENST00000557457.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000450998.1", "url": "https://www.ensembl.org/id/ENSP00000450998.1" } ] } }, { "isoform_ac": "Q8IVF2-3", "url": "https://www.uniprot.org/uniprotkb/Q8IVF2/entry#Q8IVF2-3", "sequence": { "sequence": "MSRPEAVQEATEVTLKTEVEAGASGYSVTGGGDQGIFVKQVLKDSSAAKLFNLREGDQLLSTTVFFENIKYEDALKILQYSEPYKVQFKIRRQLPAPQDEEWASSDAQHGPQGKEKEDTDVADGCRETPTKTLEGDGDQERLISKPRVGRGRQSQRERLSWPKFQSIKSKRGPGPQRSHSSSEAYEPRDAHDVSPTSTDTEAQLTVERQEQKAGPGSQRRRKFLNLRFRTGSGQGPSSTGQPGRGFQSGVGRAGVLEELGPWGDSLEETGAATGSRREERAEQDREVMPAQSMPLPTELGDPRLCEGTPQEGGLRAARLHGKTLEGQAQETAVAQRKPRAQPTPGMSREGEGEGLQSLEIGIARLSLRDTTEGGTQIGPPEIRVRVHDLKTPKFAFSTEKEPERERRLSTPQRGKRQDASSKAGTGLKGEEVEGAGWMPGREPTTHAEAQGDEGDGEEGLQRTRITEEQDKGREDTEGQIRMPKFKIPSLGWSPSKHTKTGREKATEDTEQGREGEATATADRREQRRTEEGLKDKEDSDSMTNTTKIQLIHDEKRLKKEQILTEKEVATKDSKFKMPKFKMPLFGASAPGKSMEASVDVSAPKVEADVSLLSMQGDLKTTDLSVQTPSADLEVQDGQVDVKLPEGPLPEGASLKGHLPKVQRPSLKMPKVDLKGPKLDLKGPKAEVTAPDVKMSLSSMEVDVQAPRAKLDGARLEGDLSLADKEVTAKDSKFKMPKFKMPSFGVSAPGKSMEDSVDVSAPKVEADVSLSSMQGDLKATDLSIQPPSADLEVQAGQVDVKLPEGPVPEGAGPKVHLPKVEMPSFKMPKVDLKGPQIDVKGPKLDLKGPKAEVTAPDGEVSLPSMEVDVQAQKAKLDGAWLEGDLSLADKDVTAKDSKFKMPKFKMPSFGVSAPGKSIKALVDVSAPKVEADLSLPSMQGDLKTTDLSIQPASTDLKVQADQVDVKLPEGHLPEGAGLKGHLPKVEMPSFKMPKVALKGPQVDVKGPKLDLKSPKAEVTAPDVEVSLPSVEVDVEAPGAKLDSARLEGELSLADKDVTAKDSRFKMPKFKMPSFGASAPGKSIEASVDVSAPKVEADVSLPSMQGDLKTTDLSIQPPSADLEVHAGQVDVKLLEGHVPEGAGFKGHLPKVQMPSLKMPKVDLKGPQVEVRGPKLDLKGHKAEVTAHEVAVSLPSVEVDMQAPGAKLDGAQLDGDLSLADKDVTAKDSKFKMPKFKMPSFGVSAPGKSIEASVDLSAPKVEADMSLPSMQGDLKTTDLSIQPPSTDLELQAGQLDVKLPEGPVPEGAGLKGHLPKLQMPSFKVPKVDLKGPEIDIKGPKLDLKDPKVEVTAPDVEVSLPSVEVDVEAPGAKLDGGRLEEDMSLADKDLTTKDSKFKMPKFKMPSFGVSAPGKSIEASVDVSAPKVEADVSLPSMQGDLKATDLSIQPPSADLEVQAGQVDVKLPEGPVSEGAGLKGHLPKVQMPSFKMPKVDLKGPQIDVKGPKLDLKGPKVEVTAPDVKMSLSSMEVDVQAPRAKLDGAQLEGDLSLADKAVTAKDSKFKMPKFKMPSFGVSAPGKSIEASVDVSEPKVEADVSLPSMQGDLKTTDLSIQSPSADLEVQAGQVNVKLPEGPLPEGAGFKGHLPKVQMPSLKMPKVALKGPQMDVKGPKLDLKGPKAEVMAPDVEVSLPSVEVDVEAPGAKLDSVRLEGDLSLADKDVTAKDSKFKMPKFKMPSFGVSAPGKSIEASVDVSAPKVEAEVSLPSMQGDLKTTDLCIPLPSADLVVQAGQVDMKLPEGQVPEGAGLKGHLPKVDMPSFKMPKVDLKGPQTDVKGAKLDLKGPKAEVTAPDVEVSLPSMEVDVQAQKAKLDGARLEGDLSLADKDMTAKDSKFKMPKFKMPSFGVSAPGRSIEASVDVPAPKVEADVSLPSMQGDLKTTDLSIQPPSADLKVQTGQVDVKLPEGHVPEGAGLKGHLPKVEMPSLKMPKVDLKGPQVDIKGPKLDLKDPKVEMRVPDVEVSLPSMEVDVQAPRAKLDSAHLQGDLTLANKDLTTKDSKFKMPKFKMPSFGVSAPGKSIEASVDVSPPKVEADMSLPSMQGDLKTTDLSIQPLSADVKVQAGQVDVKLLEGPVPEEVGLKGHLPKLQMPSFKVPKVDLKGPEIDIKGPKLDLKDPKVEVTAPDVEVSLPSVEVDVKAPGAKLDGARLEGDMSLADKDVTAKDSKFKMPKFKMLSFGVSALGKSIEASADVSALKVEADVSLPSMQGDLKTTDLSVQPPSADLEVQAGQVDVKLPEGPVPEGAGLKGHLPKLQMPSFKMPKVDLKGPQIDVKGPKLDLKGPKTDVMAPDVEVSQPSVEVDVEAPGAKLDGAWLEGDLSVADKDVTTKDSRFKIPKFKMPSFGVSAPGKSIEASVDVSAPKVEADGSLSSMQGDLKATDLSIQPPSADLEVQAGQVDVKLPEGPVPEGAGLKGHLPKVQMPSFKMPEMDLKGPQLDVKGPKLDLKGPKAEVTAPDVEMSLSSMEVDVQAPRAKLDGARLEGDLSLADKGVTAKDSKFKMPKFKMPSFRVSAPGESIEALVDVSELKVEADMSLPSMQGDLKTTDISIQPPSAQLEVQAGQVDVKLPEGHVPEGAGLKGHLPKLQMPSFKMPEVDLKGPQIDVKGPNVDLKGPKAEVTAPDVKMSLSSMEVDVQAPRAKLDGARLEGDLSLADKGMTAKDSKFKMPKFKMPSFGVSAPGKSIEASVDVSELKVEADGSFPSMQGDLKTTDIRIQPPSAQLEVQAGQVDVKLPEGHVPEGAGLKGHLPKVQMPSFKMPKVDLKGPQIDVKGPKLDLKGPKAEVTAPDVEVSLPSVEVDVEAPRAKLDGARLEGDLSLADKDVTAKDSKFKMPKFKMPSFGVSAPGKSIEVSVDVSAPKVEAEVSLPSMQGDLKTTDISIEPPSAQLEVQAGQVDLKLPEGHVPEGAGLKGHLPKLQMPSFKMPKVDRKGPQIDVKGPKLDLKGPKTDVTAPDVEVSQPGMEVDVEAPGAKLDGARLEGDLSLADKDVTAKDSKFKMPKFKMPSFGVSAPGKSIEVLVDVSAPKVEADLSLPSMQGDLKNTDISIEPPSAQLEVQAGQVDVKLPEGHVLEGAGLKGHLPKLQMPSFKMPKVDRKGPQIDIKGPKLDLKGPKMDVTAPDVEVSQPSMEVDVEAPGAKLDGARLEGDLSLADKDVTAKDSKFKMPKFKMPSYRASAPGKSIQASVDVSAPKAEADVSLPSMQGDLKTTDLSIQLPSVDLEVQAGQVDVKLPEGHVPEGAGLKGHLPKVEMPSFKMPKVDLKSPQVDIKGPKLDLKVPKAEVTVPDVEVSLPSVEVDVQAPRAKLDGARLEGDLSLAEKDVTAKDSKFKMPKFKMPSFGVSAPGRSIEASLDVSAPKVEADVSLSSMQGDLKATDLSIQPPSADLEVQAVQVDVELLEGPVPEGAGLKGHLPKVEMPSLKTPKVDLKGPQIDVKGPKLDLKGPKAEVRVPDVEVSLPSVEVDVQAPKAKLDAGRLEGDLSLADKDVTAKDSKFKMPKFKMPSFRVSAPGKSMEASVDVSAPKVEADVSLPSMQGDLKTTDLSIQPPSADLKVQAGQMDVKLPEGQVPEGAGLKEHLPKVEMPSLKMPKVDLKGPQVDIKGPKLDLKVSKAEVTAPDVEVSLPSVEVDVQAPRAKLDSAQLEGDLSLADKDVTAKDSKFKMPKFKMPSFGVSAPGKSIEASVHVSAPKVEADVSLPSMQGDLKTTDLSIQPHSADLTVQARQVDMKLLEGHVPEEAGLKGHLPKVQMPSFKMPKVDLKGPEIDIKGPKLDLKDPKVEVTAPDVEVSLPSVEVDVEAPGAKLDGARLEGDLSLADKDMTAKDSKFKMPKFKMPSFGVSAPGKSMEASVDVTAPKVEADVSLPSMQGDLKATDLSVQPPSADLEVQAGQVDVKLPEGPVPEGASLKGHLPKVQMPSFKMPKVDLKGPQIDVKGPKLDLKGPKAEVTAPDVKMSLSSMEVDVQAPRAKLDGVQLEGDLSLADKDVTAKDSKFKMPKFKMPSFGVSAPGKSMEASVDVSELKAKADVSLPSMQGDLKTTDLSIQSPSADLEVQAGQVDVKLPEGPLPKGAGLKGHLPKVQMPCLKMPKVALKGPQVDVKGPKLDLKGPKADVMTPVVEVSLPSMEVDVEAPGAKLDSVRLEGDLSLADKDMTAKDSKFKMPKFKMPSFGVSAPGKSIEASLDVSALKVEADVSLPSMQGDLKTTHLSIQPPSADLEVQAGQEDVKLPEGPVHEGAGLKGHLPKLQMPSFKVPKVDLKGPQIDVNVPKLDLKGPKVEVTSPNLDVSLPSMEVDIQAPGAKLDSTRLEGDLSLADKDVTAKDSKFKMPKFKMPSFGMLSPGKSIEVSVDVSAPKMEADMSIPSMQGDLKTTDLRIQAPSADLEVQAGQVDLKLPEGHMPEVAGLKGHLPKVEMPSFKMPKVDLKGPQVDVKGPKLDLKGPKAEVMAPDVEVSLPSVETDVQAPGSMLDGARLEGDLSLAHEDVAGKDSKFQGPKLSTSGFEWSSKKVSMSSSEIEGNVTFHEKTSTFPIVESVVHEGDLHDPSRDGNLGLAVGEVGMDSKFKKLHFKVPKVSFSSTKTPKDSLVPGAKSSIGLSTIPLSSSECSSFELQQVSACSEPSMQMPKVGFAGFPSSRLDLTGPHFESSILSPCEDVTLTKYQVTVPRAALAPELALEIPSGSQADIPLPKTECSTDLQPPEGVPTSQAESHSGPLNSMIPVSLGQVSFPKFYKPKFVFSVPQMAVPEGDLHAAVGAPVMSPLSPGERVQCPLPSTQLPSPGTCVSQGPEELVASLQTSVVAPGEAPSEDADHEGKGSPLKMPKIKLPSFRWSPKKETGPKVDPECSVEDSKLSLVLDKDEVAPQSAIHMDLPPERDGEKGRSTKPGFAMPKLALPKMKASKSGVSLPQRDVDPSLSSATAGGSFQDTEKASSDGGRGGLGATASATGSEGVNLHRPQVHIPSLGFAKPDLRSSKAKVEVSQPEADLPLPKHDLSTEGDSRGCGLGDVPVSQPCGEGIAPTPEDPLQPSCRKPDAEVLTVESPEEEAMTKYSQESWFKMPKFRMPSLRRSFRDRGGAGKLEVAQTQAPAATGGEAAAKVKEFLVSGSNVEAAMSLQLPEADAEVTASESKSSTDILRCDLDSTGLKLHLSTAGMTGDELSTSEVRIHPSKGPLPFQMPGMRLPETQVLPGEIDETPLSKPGHDLASMEDKTEKWSSQPEGPLKLKASSTDMPSQISVVNVDQLWEDSVLTVKFPKLMVPRFSFPAPSSEDDVFIPTVREVQCPEANIDTALCKESPGLWGASILKAGAGVPGEQPVDLNLPLEAPPISKVRVHIQGAQVESQEVTIHSIVTPEFVDLSVPRTFSTQIVRESEIPTSEIQTPSYGFSLLKVKIPEPHTQARVYTTMTQHSRTQEGTEEAPIQATPGVDSISGDLQPDTGEPFEMISSSVNVLGQQTLTFEVPSGHQLADSCSDEEPAEILEFPPDDSQEATTPLADEGRAPKDKPESKKSGLLWFWLPNIGFSSSVDETGVDSKNDVQRSAPIQTQPEARPEAELPKKQEKAGWFRFPKLGFSSSPTKKSKSTEDGAELEEQKLQEETITFFDARESFSPEEKEEGELIGPVGTGLDSRVMVTSAARTELILPEQDRKADDESKGSGLGPNEG", "length": 5695, "header": "sp|Q8IVF2-3|AHNK2_HUMAN Isoform 3 of Protein AHNAK2 OS=Homo sapiens OX=9606 GN=AHNAK2 PE=1 SV=2 CANONICAL=Q8IVF2-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_pos": 1181, "start_aa": "Ser", "end_pos": 1181, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser1181", "evidence": [ { "id": "31373491", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31373491" }, { "id": "Q8IVF2", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q8IVF2" } ], "filter_code": "00000000000000010000.0000000.00000001000000.1000000.0100000000.110100100001111011.10000.01001" }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_pos": 1198, "start_aa": "Ser", "end_pos": 1198, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser1198", "evidence": [ { "id": "31373491", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31373491" }, { "id": "Q8IVF2", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q8IVF2" } ], "filter_code": "00000000000000010000.0000000.00000001000000.1000000.0100000000.110100100001111011.10000.01001" }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_pos": 1201, "start_aa": "Ser", "end_pos": 1201, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser1201", "evidence": [ { "id": "31373491", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31373491" }, { "id": "Q8IVF2", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q8IVF2" } ], "filter_code": "00000000000000010000.0000000.00000001000000.1000000.0100000000.110100100001111011.10000.01001" }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_pos": 1293, "start_aa": "Ser", "end_pos": 1293, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser1293", "evidence": [ { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "Q8IVF2", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8IVF2" }, { "id": "28657654", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28657654" }, { "id": "36240223", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36240223" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "39531497", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39531497" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "37340703", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37340703" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" }, { "id": "30620550", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30620550" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "31373491", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31373491" }, { "id": "39534244", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39534244" }, { "id": "Q8IVF2", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q8IVF2" } ], "filter_code": "00000000000000010000.0000000.00000001000000.1000000.0100000000.110100100001111011.10000.01001" }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_pos": 1567, "start_aa": "Ser", "end_pos": 1567, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser1567", "evidence": [ { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "Q8IVF2", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8IVF2" }, { "id": "28657654", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28657654" }, { "id": "36240223", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36240223" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "39531497", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39531497" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "39302247", "database": "PubMed", 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"evidence": [ { "database": "Data Submission", "id": "GLY_000888", "url": "http://data.glygen.org/GLY_000888" } ], "reference": [ { "type": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" } ] }, { "title": "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.", "journal": "Cell", "date": "2006", "authors": "Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q8IVF2", "url": "https://www.uniprot.org/uniprotkb/Q8IVF2" } ], "reference": [ { "type": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" } ] }, { "title": "AHNAK, a novel component of the dysferlin protein complex, redistributes to the cytoplasm with dysferlin during skeletal muscle regeneration.", "journal": "FASEB J.", "date": "2007", "authors": "Huang Y, Laval SH, van Remoortere A, Baudier J, Benaud C, Anderson LV, Straub V, Deelder A, Frants RR, den Dunnen JT, Bushby K, van der Maarel SM", "evidence": [ { "database": "UniProtKB", "id": "Q8IVF2", "url": "https://www.uniprot.org/uniprotkb/Q8IVF2" } ], "reference": [ { "type": "PubMed", "id": "17185750", "url": "https://glygen.org/publication/PubMed/17185750" } ] }, { "title": "A quantitative atlas of mitotic phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q8IVF2", "url": "https://www.uniprot.org/uniprotkb/Q8IVF2" }, { "database": "iPTMnet", "id": "Q8IVF2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8IVF2" } ], "reference": [ { "type": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ] }, { "title": "Lysine acetylation targets protein complexes and co-regulates major cellular functions.", "journal": "Science (New York, N.Y.)", "date": "2009", "authors": "Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q8IVF2", "url": "https://www.uniprot.org/uniprotkb/Q8IVF2" } ], "reference": [ { "type": "PubMed", "id": "19608861", "url": "https://glygen.org/publication/PubMed/19608861" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q8IVF2", "url": "https://www.uniprot.org/uniprotkb/Q8IVF2" }, { "database": "iPTMnet", "id": "Q8IVF2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8IVF2" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": 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Biol. Chem.", "date": "2014", "authors": "Han H, Kursula P", "evidence": [ { "database": "UniProtKB", "id": "Q8IVF2", "url": "https://www.uniprot.org/uniprotkb/Q8IVF2" }, { "database": "RefSeq", "id": "NP_612429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612429" } ], "reference": [ { "type": "PubMed", "id": "24675079", "url": "https://glygen.org/publication/PubMed/24675079" } ] }, { "title": "Impact of genomic polymorphisms on the repertoire of human MHC class I-associated peptides.", "journal": "Nature communications", "date": "2014-04-09", "authors": "Granados Diana Paola, Sriranganadane Dev, Daouda Tariq, Zieger Antoine, Laumont C\u00e9line M, Caron-Lizotte Olivier, Boucher Genevi\u00e8ve, Hardy Marie-Pierre, Gendron Patrick, C\u00f4t\u00e9 Caroline, Lemieux S\u00e9bastien, Thibault Pierre, Perreault Claude", "evidence": [ { "database": "IEDB", "id": "214530", "url": "https://www.iedb.org/epitope/214530" } ], "reference": [ { "type": "PubMed", "id": "24714562", "url": "https://glygen.org/publication/PubMed/24714562" } ] }, { "title": "Naturally processed non-canonical HLA-A*02:01 presented peptides.", "journal": "The Journal of biological chemistry", "date": "2015-01-30", "authors": "Hassan Chopie, Chabrol Eric, Jahn Lorenz, Kester Michel G D, de Ru Arnoud H, Drijfhout Jan W, Rossjohn Jamie, Falkenburg J H Frederik, Heemskerk Mirjam H M, Gras Stephanie, van Veelen Peter A", "evidence": [ { "database": "IEDB", "id": "239826", "url": "https://www.iedb.org/epitope/239826" } ], "reference": [ { "type": "PubMed", "id": "25505266", "url": "https://glygen.org/publication/PubMed/25505266" } ] }, { "title": "Mass spectrometry of human leukocyte antigen class I peptidomes reveals strong effects of protein abundance and turnover on antigen presentation.", "journal": "Molecular & cellular proteomics : MCP", "date": "2015-03", "authors": "Bassani-Sternberg Michal, Pletscher-Frankild Sune, Jensen Lars Juhl, Mann Matthias", "evidence": [ { "database": "IEDB", "id": "477012", "url": "https://www.iedb.org/epitope/477012" }, { "database": "IEDB", "id": "477159", "url": "https://www.iedb.org/epitope/477159" }, { "database": "IEDB", "id": "480515", "url": "https://www.iedb.org/epitope/480515" }, { "database": "IEDB", "id": "480933", "url": "https://www.iedb.org/epitope/480933" }, { "database": "IEDB", "id": "484245", "url": "https://www.iedb.org/epitope/484245" }, { "database": "IEDB", "id": "484389", "url": "https://www.iedb.org/epitope/484389" } ], "reference": [ { "type": "PubMed", "id": "25576301", "url": "https://glygen.org/publication/PubMed/25576301" } ] }, { "title": "Exploration of peptides bound to MHC class I molecules in melanoma.", "journal": "Pigment cell & melanoma research", "date": "2015-05", "authors": "Pritchard Antonia L, Hastie Marcus L, Neller Michelle, Gorman Jeffrey J, Schmidt Chris W, Hayward Nicholas K", "evidence": [ { "database": "IEDB", "id": "541525", "url": "https://www.iedb.org/epitope/541525" }, { "database": "IEDB", "id": "545123", "url": "https://www.iedb.org/epitope/545123" }, { "database": "IEDB", "id": "545236", "url": "https://www.iedb.org/epitope/545236" }, { "database": "IEDB", "id": "545518", "url": "https://www.iedb.org/epitope/545518" } ], "reference": [ { "type": "PubMed", "id": "25645385", "url": "https://glygen.org/publication/PubMed/25645385" } ] }, { "title": "System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.", "journal": "Mol. 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Proteomics", "date": "2015", "authors": "Xiao Zhenyu, Chang Jer-Gung, Hendriks Ivo A, Sigur\u00f0sson J\u00f3n Otti, Olsen Jesper V, Vertegaal Alfred C O", "evidence": [ { "database": "UniProtKB", "id": "Q8IVF2", "url": "https://www.uniprot.org/uniprotkb/Q8IVF2" } ], "reference": [ { "type": "PubMed", "id": "25755297", "url": "https://glygen.org/publication/PubMed/25755297" } ] }, { "title": "SUMO-2 orchestrates chromatin modifiers in response to DNA damage.", "journal": "Cell Rep.", "date": "2015", "authors": "Hendriks Ivo A, Treffers Louise W, Verlaan-de Vries Matty, Olsen Jesper V, Vertegaal Alfred C O", "evidence": [ { "database": "UniProtKB", "id": "Q8IVF2", "url": "https://www.uniprot.org/uniprotkb/Q8IVF2" } ], "reference": [ { "type": "PubMed", "id": "25772364", "url": "https://glygen.org/publication/PubMed/25772364" } ] }, { "title": "Understanding the obstacle of incompatibility at residue 156 within HLA-B*35 subtypes.", "journal": "Immunogenetics", "date": "2016-04", "authors": "Manandhar Trishna, Kunze-Schumacher Heike, Huyton Trevor, Celik Alexander A, Blasczyk Rainer, Bade-Doeding Christina", "evidence": [ { "database": "IEDB", "id": "531358", "url": "https://www.iedb.org/epitope/531358" } ], "reference": [ { "type": "PubMed", "id": "26758079", "url": "https://glygen.org/publication/PubMed/26758079" } ] }, { "title": "Mass spectrometric analysis of the HLA class I peptidome of melanoma cell lines as a promising tool for the identification of putative tumor-associated HLA epitopes.", "journal": "Cancer immunology, immunotherapy : CII", "date": "2016-11", "authors": "Gloger Andreas, Ritz Danilo, Fugmann Tim, Neri Dario", "evidence": [ { "database": "IEDB", "id": "562484", "url": "https://www.iedb.org/epitope/562484" }, { "database": "IEDB", "id": "564770", "url": "https://www.iedb.org/epitope/564770" } ], "reference": [ { "type": "PubMed", "id": "27600516", "url": "https://glygen.org/publication/PubMed/27600516" } ] }, { "title": "Immunogenic HLA-DR-Presented Self-Peptides Identified Directly from Clinical Samples of Synovial Tissue, Synovial Fluid, or Peripheral Blood in Patients with Rheumatoid Arthritis or Lyme Arthritis.", "journal": "Journal of proteome research", "date": "2017-01-06", "authors": "Wang Qi, Drouin Elise E, Yao Chunxiang, Zhang Jiyang, Huang Yu, Leon Deborah R, Steere Allen C, Costello Catherine E", "evidence": [ { "database": "IEDB", "id": "592692", "url": "https://www.iedb.org/epitope/592692" } ], "reference": [ { "type": "PubMed", "id": "27726376", "url": "https://glygen.org/publication/PubMed/27726376" } ] }, { "title": "Quantitative proteomics identifies altered O-GlcNAcylation of structural, synaptic and memory-associated proteins in Alzheimer's disease.", "journal": "The Journal of pathology", "date": "2017", "authors": "Wang S, Yang F, Petyuk VA, Shukla AK, Monroe ME, Gritsenko MA, Rodland KD, Smith RD, Qian WJ, Gong CX, Liu T", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8IVF2", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8IVF2" }, { "database": "O-GlcNAc Atlas", "id": "Q8IVF2", "url": "https://oglcnac.org/atlas/detail/Q8IVF2" } ], "reference": [ { "type": "PubMed", "id": "28657654", "url": "https://glygen.org/publication/PubMed/28657654" } ] }, { "title": "High-throughput and Sensitive Immunopeptidomics Platform Reveals Profound Interferon\u03b3-Mediated Remodeling of the Human Leukocyte Antigen (HLA) Ligandome.", "journal": "Molecular & cellular proteomics : MCP", "date": "2018-03", "authors": "Chong Chloe, Marino Fabio, Pak HuiSong, Racle Julien, Daniel Roy T, M\u00fcller Markus, Gfeller David, Coukos George, Bassani-Sternberg Michal", "evidence": [ { "database": "IEDB", "id": "1372762", "url": "https://www.iedb.org/epitope/1372762" } ], "reference": [ { "type": "PubMed", "id": "29242379", "url": "https://glygen.org/publication/PubMed/29242379" } ] }, { "title": "The Peptide Repertoire of HLA-B27 may include Ligands with Lysine at P2 Anchor Position.", "journal": "Proteomics", "date": "2018-05", "authors": "Yair-Sabag Shira, Tedeschi Valentina, Vitulano Carolina, Barnea Eilon, Glaser Fabian, Melamed Kadosh Dganit, Taurog Joel D, Fiorillo Maria Teresa, Sorrentino Rosa, Admon Arie", "evidence": [ { "database": "IEDB", "id": "480933", "url": "https://www.iedb.org/epitope/480933" }, { "database": "IEDB", "id": "795872", "url": "https://www.iedb.org/epitope/795872" } ], "reference": [ { "type": "PubMed", "id": "29393594", "url": "https://glygen.org/publication/PubMed/29393594" } ] }, { "title": "The natural HLA ligandome of glioblastoma stem-like cells: antigen discovery for T cell-based immunotherapy.", "journal": "Acta neuropathologica", "date": "2018-06", "authors": "Neidert Marian Christoph, Kowalewski Daniel Johannes, Silginer Manuela, Kapolou Konstantina, Backert Linus, Freudenmann Lena Katharina, Peper Janet Kerstin, Marcu Ana, Wang Sophie Shih-Y\u00fcng, Walz Juliane Sarah, Wolpert Fabian, Rammensee Hans-Georg, Henschler Reinhard, Lamszus Katrin, Westphal Manfred, Roth Patrick, Regli Luca, Stevanovi\u0107 Stefan, Weller Michael, Eisele G\u00fcnter", "evidence": [ { "database": "IEDB", "id": "545236", "url": "https://www.iedb.org/epitope/545236" }, { "database": "IEDB", "id": "992689", "url": "https://www.iedb.org/epitope/992689" }, { "database": "IEDB", "id": "1089491", "url": "https://www.iedb.org/epitope/1089491" }, { "database": "IEDB", "id": "1092119", "url": "https://www.iedb.org/epitope/1092119" }, { "database": "IEDB", "id": "1105058", "url": "https://www.iedb.org/epitope/1105058" } ], "reference": [ { "type": "PubMed", "id": "29557506", "url": "https://glygen.org/publication/PubMed/29557506" } ] }, { "title": "Immunopeptidomic Profiling of HLA-A2-Positive Triple Negative Breast Cancer Identifies Potential Immunotherapy Target Antigens.", "journal": "Proteomics", "date": "2018-06", "authors": "Ternette Nicola, Olde Nordkamp Marloes J M, M\u00fcller Julius, Anderson Amanda P, Nicastri Annalisa, Hill Adrian V S, Kessler Benedikt M, Li Demin", "evidence": [ { "database": "IEDB", "id": "480933", "url": "https://www.iedb.org/epitope/480933" }, { "database": "IEDB", "id": "545236", "url": "https://www.iedb.org/epitope/545236" }, { "database": "IEDB", "id": "545518", "url": "https://www.iedb.org/epitope/545518" }, { "database": "IEDB", "id": "774222", "url": "https://www.iedb.org/epitope/774222" }, { "database": "IEDB", "id": "776320", "url": "https://www.iedb.org/epitope/776320" }, { "database": "IEDB", "id": "779568", "url": "https://www.iedb.org/epitope/779568" } ], "reference": [ { "type": "PubMed", "id": "29786170", "url": "https://glygen.org/publication/PubMed/29786170" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8IVF2", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8IVF2" }, { "database": "O-GlcNAc Atlas", "id": "Q8IVF2", "url": "https://oglcnac.org/atlas/detail/Q8IVF2" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8IVF2", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8IVF2" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "The Length Distribution and Multiple Specificity of Naturally Presented HLA-I Ligands.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2018-12-15", "authors": "Gfeller David, Guillaume Philippe, Michaux Justine, Pak Hui-Song, Daniel Roy T, Racle Julien, Coukos George, Bassani-Sternberg Michal", "evidence": [ { "database": "IEDB", "id": "876044", "url": "https://www.iedb.org/epitope/876044" } ], "reference": [ { "type": "PubMed", "id": "30429286", "url": "https://glygen.org/publication/PubMed/30429286" } ] }, { "title": "TAPBPR mediates peptide dissociation from MHC class I using a leucine lever.", "journal": "eLife", "date": "2018", "authors": "Ilca FT, Neerincx A, Hermann C, Marcu A, Stevanovic S, Deane JE, Boyle LH", "evidence": [ { "database": "IEDB", "id": "960148", "url": "https://www.iedb.org/epitope/960148" }, { "database": "IEDB", "id": "960775", "url": "https://www.iedb.org/epitope/960775" } ], "reference": [ { "type": "PubMed", "id": "30484775", "url": "https://glygen.org/publication/PubMed/30484775" } ] }, { "title": "An Isotope-Coded Photocleavable Probe for Quantitative Profiling of Protein O-GlcNAcylation.", "journal": "ACS chemical biology", "date": "2019", "authors": "Li J, Li Z, Duan X, Qin K, Dang L, Sun S, Cai L, Hsieh-Wilson LC, Wu L, Yi W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8IVF2", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8IVF2" } ], "reference": [ { "type": "PubMed", "id": "30620550", "url": "https://glygen.org/publication/PubMed/30620550" } ] }, { "title": "Pro-inflammatory Cytokines Alter the Immunopeptidome Landscape by Modulation of HLA-B Expression.", "journal": "Frontiers in immunology", "date": "2019", "authors": "Javitt Aaron, Barnea Eilon, Kramer Matthias P, Wolf-Levy Hila, Levin Yishai, Admon Arie, Merbl Yifat", "evidence": [ { "database": "IEDB", "id": "545123", "url": "https://www.iedb.org/epitope/545123" }, { "database": "IEDB", "id": "562484", "url": "https://www.iedb.org/epitope/562484" }, { "database": "IEDB", "id": "953320", "url": 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"reference": [ { "type": "PubMed", "id": "31217245", "url": "https://glygen.org/publication/PubMed/31217245" } ] }, { "title": "Aspartate Residues Far from the Active Site Drive O-GlcNAc Transferase Substrate Selection.", "journal": "Journal of the American Chemical Society", "date": "2019", "authors": "Joiner CM, Levine ZG, Aonbangkhen C, Woo CM, Walker S", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8IVF2", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8IVF2" }, { "database": "O-GlcNAc Atlas", "id": "Q8IVF2", "url": "https://oglcnac.org/atlas/detail/Q8IVF2" } ], "reference": [ { "type": "PubMed", "id": "31373491", "url": "https://glygen.org/publication/PubMed/31373491" } ] }, { "title": "Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.", "journal": "Nature communications", "date": "2019", "authors": "Hao Y, Fan X, Shi Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8IVF2", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8IVF2" }, { "database": "O-GlcNAc Atlas", "id": "Q8IVF2", "url": "https://oglcnac.org/atlas/detail/Q8IVF2" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "A large peptidome dataset improves HLA class I epitope prediction across most of the human population.", "journal": "Nature biotechnology", "date": "2020-02", "authors": "Sarkizova Siranush, Klaeger Susan, Le Phuong M, Li Letitia W, Oliveira Giacomo, Keshishian Hasmik, Hartigan Christina R, Zhang Wandi, Braun David A, Ligon Keith L, Bachireddy Pavan, Zervantonakis Ioannis K, Rosenbluth Jennifer M, Ouspenskaia Tamara, Law Travis, Justesen Sune, Stevens Jonathan, Lane William J, Eisenhaure Thomas, Lan Zhang Guang, Clauser Karl R, Hacohen Nir, Carr Steven A, Wu Catherine J, Keskin Derin B", "evidence": [ { "database": "IEDB", "id": "1007389", "url": "https://www.iedb.org/epitope/1007389" }, { "database": "IEDB", "id": "1037216", "url": "https://www.iedb.org/epitope/1037216" } ], "reference": [ { "type": "PubMed", "id": "31844290", "url": "https://glygen.org/publication/PubMed/31844290" } ] }, { "title": "Mass Spectrometry Based Immunopeptidomics Leads to Robust Predictions of Phosphorylated HLA Class I Ligands.", "journal": "Molecular & cellular proteomics : MCP", "date": "2020-02", "authors": "Solleder Marthe, Guillaume Philippe, Racle Julien, Michaux Justine, Pak Hui-Song, M\u00fcller Markus, Coukos George, Bassani-Sternberg Michal, Gfeller David", "evidence": [ { "database": "IEDB", "id": "992689", "url": "https://www.iedb.org/epitope/992689" } ], "reference": [ { "type": "PubMed", "id": "31848261", "url": "https://glygen.org/publication/PubMed/31848261" } ] }, { "title": "Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes.", "journal": "Nature communications", "date": "2020-03-10", "authors": "Chong Chloe, M\u00fcller Markus, Pak HuiSong, Harnett Dermot, Huber Florian, Grun Delphine, Leleu Marion, Auger Aymeric, Arnaud Marion, Stevenson Brian J, Michaux Justine, Bilic Ilija, Hirsekorn Antje, Calviello Lorenzo, Sim\u00f3-Riudalbas Laia, Planet Evarist, Lubi\u0144ski Jan, Bry\u015bkiewicz Marta, Wiznerowicz Maciej, Xenarios Ioannis, Zhang Lin, Trono Didier, Harari Alexandre, Ohler Uwe, Coukos George, Bassani-Sternberg Michal", "evidence": [ { "database": "IEDB", "id": "480933", "url": "https://www.iedb.org/epitope/480933" }, { "database": "IEDB", "id": "545518", "url": "https://www.iedb.org/epitope/545518" }, { "database": "IEDB", "id": "992689", "url": "https://www.iedb.org/epitope/992689" }, { "database": "IEDB", "id": "1283496", "url": "https://www.iedb.org/epitope/1283496" }, { "database": "IEDB", "id": "2061749", "url": "https://www.iedb.org/epitope/2061749" }, { "database": "IEDB", "id": "2063046", "url": 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"https://www.iedb.org/epitope/2042238" }, { "database": "IEDB", "id": "2042428", "url": "https://www.iedb.org/epitope/2042428" }, { "database": "IEDB", "id": "2042943", "url": "https://www.iedb.org/epitope/2042943" }, { "database": "IEDB", "id": "2042944", "url": "https://www.iedb.org/epitope/2042944" }, { "database": "IEDB", "id": "2048880", "url": "https://www.iedb.org/epitope/2048880" }, { "database": "IEDB", "id": "2049253", "url": "https://www.iedb.org/epitope/2049253" }, { "database": "IEDB", "id": "2049622", "url": "https://www.iedb.org/epitope/2049622" }, { "database": "IEDB", "id": "2050890", "url": "https://www.iedb.org/epitope/2050890" }, { "database": "IEDB", "id": "2051580", "url": "https://www.iedb.org/epitope/2051580" }, { "database": "IEDB", "id": "2052701", "url": "https://www.iedb.org/epitope/2052701" }, { "database": "IEDB", "id": "2055972", "url": "https://www.iedb.org/epitope/2055972" }, { "database": "IEDB", "id": "2058288", "url": "https://www.iedb.org/epitope/2058288" }, { "database": "IEDB", "id": "2058806", "url": "https://www.iedb.org/epitope/2058806" } ], "reference": [ { "type": "PubMed", "id": "35051231", "url": "https://glygen.org/publication/PubMed/35051231" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8IVF2", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8IVF2" }, { "database": "O-GlcNAc Atlas", "id": "Q8IVF2", "url": "https://oglcnac.org/atlas/detail/Q8IVF2" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "Tumour-associated antigenic peptides are present in the HLA class I ligandome of cancer cell line derived extracellular vesicles.", "journal": "Immunology", "date": "2022-06", "authors": "Kumar Pankaj, Boyne Caitlin, Brown Sydney, Qureshi Ayesha, Thorpe Peter, Synowsky Silvia A, Shirran Sally, Powis Simon J", "evidence": [ { "database": "IEDB", "id": "480933", "url": "https://www.iedb.org/epitope/480933" }, { "database": "IEDB", "id": "955016", "url": "https://www.iedb.org/epitope/955016" }, { "database": "IEDB", "id": "2002329", "url": "https://www.iedb.org/epitope/2002329" }, { "database": "IEDB", "id": "2002399", "url": "https://www.iedb.org/epitope/2002399" } ], "reference": [ { "type": "PubMed", "id": "35318648", "url": "https://glygen.org/publication/PubMed/35318648" } ] }, { "title": "Cell-type-specific labeling and profiling of glycans in living mice.", "journal": "Nature chemical biology", "date": "2022-06", "authors": "Fan Xinqi, Song Qitao, Sun De-En, Hao Yi, Wang Jingyang, Wang Chunting, Chen Xing", "evidence": [ { "database": "O-GlcNAc Atlas", "id": "Q8IVF2", "url": "https://oglcnac.org/atlas/detail/Q8IVF2" } ], "reference": [ { "type": "PubMed", "id": "35513511", "url": "https://glygen.org/publication/PubMed/35513511" } ] }, { "title": "Soluble HLA peptidome of pleural effusions is a valuable source for tumor antigens.", "journal": "Journal for immunotherapy of cancer", "date": "2022-05", "authors": "Khazan-Kost Sofia, Cafri Gal, Melamed Kadosh Dganit, Mooshayef Navit, Chatterji Sumit, Dominissini Dan, Manor Sigal, Zisser Bracha, Broday Limor, Talalai Efrosiniia, Shemer Anat, Zadok Oranit, Ofek Efrat, Onn Amir, Admon Arie, Peled Michael", "evidence": [ { "database": "IEDB", "id": "477012", "url": "https://www.iedb.org/epitope/477012" }, { "database": "IEDB", "id": "480933", "url": "https://www.iedb.org/epitope/480933" }, { "database": "IEDB", "id": "2260072", "url": "https://www.iedb.org/epitope/2260072" }, { "database": "IEDB", "id": "2262156", "url": "https://www.iedb.org/epitope/2262156" } ], "reference": [ { "type": "PubMed", "id": "35580925", "url": "https://glygen.org/publication/PubMed/35580925" } ] }, { "title": "Multi-Omic Analysis of Two Common P53 Mutations: Proteins Regulated by Mutated P53 as Potential Targets for Immunotherapy.", "journal": "Cancers", "date": "2022-08-17", "authors": "Vadakekolathu Jayakumar, Boocock David J, Pandey Kirti, Guinn Barbara-Ann, Legrand Antoine, Miles Amanda K, Coveney Clare, Ayala Rochelle, Purcell Anthony W, McArdle Stephanie E", "evidence": [ { "database": "IEDB", "id": "480933", "url": "https://www.iedb.org/epitope/480933" }, { "database": "IEDB", "id": "545123", "url": "https://www.iedb.org/epitope/545123" }, { "database": "IEDB", "id": "545236", "url": "https://www.iedb.org/epitope/545236" }, { "database": "IEDB", "id": "545518", "url": "https://www.iedb.org/epitope/545518" }, { "database": "IEDB", "id": "1283496", "url": "https://www.iedb.org/epitope/1283496" }, { "database": "IEDB", "id": "1995821", "url": "https://www.iedb.org/epitope/1995821" } ], "reference": [ { "type": "PubMed", "id": "36010968", "url": "https://glygen.org/publication/PubMed/36010968" } ] }, { "title": "AHNAK2 promotes the progression of differentiated thyroid cancer through PI3K/AKT signaling pathway.", "journal": "Current cancer drug targets", "date": "2022-09-08", "authors": "Xu Min, Wen Jialiang, Xu Qiding, Li Huihui, Lin Bangyi, Bhandari Adheesh, Qu Jinmiao", "evidence": [ { "database": "RefSeq", "id": "NP_612429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612429" } ], "reference": [ { "type": "PubMed", "id": "36089788", "url": "https://glygen.org/publication/PubMed/36089788" } ] }, { "title": "The Autophagy Receptor TAX1BP1 (T6BP) improves antigen presentation by MHC-II molecules.", "journal": "EMBO reports", "date": "2022-12-06", "authors": "Sarango Gabriela, Richetta Cl\u00e9mence, Pereira Mathias, Kumari Anita, Ghosh Michael, Bertrand Lisa, Pionneau C\u00e9dric, Le Gall Morgane, Gr\u00e9goire Sylvie, Jeger-Madiot Rapha\u00ebl, Rosoy Elina, Subra Fr\u00e9d\u00e9ric, Delelis Olivier, Faure Mathias, Esclatine Audrey, Graff-Dubois St\u00e9phanie, Stevanovi\u0107 Stefan, Manoury B\u00e9n\u00e9dicte, Ramirez Bertha Cecilia, Moris Arnaud", "evidence": [ { "database": "IEDB", "id": "545236", "url": "https://www.iedb.org/epitope/545236" }, { "database": "IEDB", "id": "545518", "url": "https://www.iedb.org/epitope/545518" }, { "database": "IEDB", "id": "960775", "url": "https://www.iedb.org/epitope/960775" }, { "database": "IEDB", "id": "2163378", "url": "https://www.iedb.org/epitope/2163378" }, { "database": "IEDB", "id": "2163606", "url": "https://www.iedb.org/epitope/2163606" }, { "database": "IEDB", "id": "2171245", "url": "https://www.iedb.org/epitope/2171245" } ], "reference": [ { "type": "PubMed", "id": "36215666", "url": "https://glygen.org/publication/PubMed/36215666" } ] }, { "title": "Design and Preparation of Novel Nitro-Oxide-Grafted Nanospheres with Enhanced Hydrogen Bonding Interaction for O-GlcNAc Analysis.", "journal": "ACS applied materials & interfaces", "date": "2022-10-26", "authors": "Wu Ci, Shi Song, Hou Chunyan, Luo Yang, Byers Stephen, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8IVF2", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8IVF2" }, { "database": "O-GlcNAc Atlas", "id": "Q8IVF2", "url": "https://oglcnac.org/atlas/detail/Q8IVF2" } ], "reference": [ { "type": "PubMed", "id": "36240223", "url": "https://glygen.org/publication/PubMed/36240223" } ] }, { "title": "Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes.", "journal": "Nature communications", "date": "2022-10-14", "authors": "Mayer Rupert L, Verbeke Rein, Asselman Caroline, Aernout Ilke, Gul Adillah, Eggermont Denzel, Boucher Katie, Thery Fabien, Maia Teresa M, Demol Hans, Gabriels Ralf, Martens Lennart, B\u00e9cavin Christophe, De Smedt Stefaan C, Vandekerckhove Bart, Lentacker Ine, Impens Francis", "evidence": [ { "database": "IEDB", "id": "960775", "url": "https://www.iedb.org/epitope/960775" }, { "database": "IEDB", "id": "2244489", "url": "https://www.iedb.org/epitope/2244489" }, { "database": "IEDB", "id": "2244496", "url": "https://www.iedb.org/epitope/2244496" }, { "database": "IEDB", "id": "2245248", "url": "https://www.iedb.org/epitope/2245248" } ], "reference": [ { "type": "PubMed", "id": "36241641", "url": "https://glygen.org/publication/PubMed/36241641" } ] }, { "title": "Extracellular arginine availability modulates eIF2\u03b1 O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis.", "journal": "Journal of biomedical science", "date": "2023-05-22", "authors": "Hung Yu-Wen, Ouyang Ching, Ping Xiaoli, Qi Yue, Wang Yi-Chang, Kung Hsing-Jien, Ann David K", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8IVF2", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8IVF2" } ], "reference": [ { "type": "PubMed", "id": "37217939", "url": "https://glygen.org/publication/PubMed/37217939" } ] }, { "title": "`Two Birds One Stone` Strategy for the Site-Specific Analysis of Core Fucosylation and O-GlcNAcylation.", "journal": "Journal of the American Chemical Society", "date": "2023-07-26", "authors": "Luo Yawen, Wang Yuqiu, Tian Yinping, Zhou Hu, Wen Liuqing", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8IVF2", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8IVF2" } ], "reference": [ { "type": "PubMed", "id": "37340703", "url": "https://glygen.org/publication/PubMed/37340703" } ] }, { "title": "Downregulation of AHNAK2 inhibits cell cycle of lung adenocarcinoma cells by interacting with RUVBL1.", "journal": "Thoracic cancer", "date": "2023-08", "authors": "Li Xin, Li Hui, Shao Ming-Ming, Miao Jinbai, Fu Yili, Hu Bin", "evidence": [ { "database": "RefSeq", "id": "NP_612429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612429" } ], "reference": [ { "type": "PubMed", "id": "37349884", "url": "https://glygen.org/publication/PubMed/37349884" } ] }, { "title": "Targeting of intracellular oncoproteins with peptide-centric CARs.", "journal": "Nature", "date": "2023-11", "authors": "Yarmarkovich Mark, Marshall Quinlen F, Warrington John M, Premaratne Rasika, Farrel Alvin, Groff David, Li Wei, di Marco Moreno, Runbeck Erin, Truong Hau, Toor Jugmohit S, Tripathi Sarvind, Nguyen Son, Shen Helena, Noel Tiffany, Church Nicole L, Weiner Amber, Kendsersky Nathan, Martinez Dan, Weisberg Rebecca, Christie Molly, Eisenlohr Laurence, Bosse Kristopher R, Dimitrov Dimiter S, Stevanovic Stefan, Sgourakis Nikolaos G, Kiefel Ben R, Maris John M", "evidence": [ { "database": "IEDB", "id": "1283496", "url": "https://www.iedb.org/epitope/1283496" } ], "reference": [ { "type": "PubMed", "id": "37938771", "url": "https://glygen.org/publication/PubMed/37938771" } ] }, { "title": "Studying the O-GlcNAcome of human placentas using banked tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8IVF2", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8IVF2" }, { "database": "O-GlcNAc Atlas", "id": "Q8IVF2", "url": "https://oglcnac.org/atlas/detail/Q8IVF2" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "title": "Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics.", "journal": "Journal of proteome research", "date": "2024-10-04", "authors": "Hou Chunyan, Wu Ci, Wu Zichun, Cheng Yifan, Li Weiyu, Sun Hui, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8IVF2", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8IVF2" }, { "database": "O-GlcNAc Atlas", "id": "Q8IVF2", "url": "https://oglcnac.org/atlas/detail/Q8IVF2" } ], "reference": [ { "type": "PubMed", "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247" } ] }, { "title": "Ultradeep O-GlcNAc proteomics reveals widespread O-GlcNAcylation on tyrosine residues of proteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2024-11-19", "authors": "Hou Chunyan, Deng Jingtao, Wu Ci, Zhang Jing, Byers Stephen, Moremen Kelley W, Pei Huadong, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8IVF2", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8IVF2" }, { "database": "O-GlcNAc Atlas", "id": "Q8IVF2", "url": "https://oglcnac.org/atlas/detail/Q8IVF2" } ], "reference": [ { "type": "PubMed", "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497" } ] }, { "title": "Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation.", "journal": "National science review", "date": "2024-11", "authors": "Xiong Yingying, Lu Zhuoer, Shao Yuyin, Meng Peiyi, Wang Guoli, Zhou Xinwen, Yao Jun, Bao Huimin, Lu Haojie", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8IVF2", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8IVF2" }, { "database": "O-GlcNAc Atlas", "id": "Q8IVF2", "url": "https://oglcnac.org/atlas/detail/Q8IVF2" } ], "reference": [ { "type": "PubMed", "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244" } ] } ], "pathway": [ { "id": "hsa:113146", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:113146", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A7N9VR94-1", "protein_name": "AHNAK nucleoprotein 2", "gene_name": "Ahnak2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MCDCFHVVLPTWPGAPGSVSGRQLQQREPEAETEDDSVTEGPAGEIIRPRPQGSSPVYEYTAEGAGFGGQENSQGRHSSSGRRRSWWKRGSGDSAAFTSMSHPEESTEVTLKTDVESGASGYSVTGGGDQGIFVKQVLKDSSAAKLFNLREGDQLLSATIFFDHMKYEDALKILQYSEPYKVQFRIKRKLSASKGEEGAVQHSQQGQENQDKDIADGCMETPTKTLEEAGDRERLISKSRDGHHRRTQDRFSWPKFQTLRSKQRAGPRRSHSSSEASEHRETRDMSPTSTDTEVHRTADRQERNTGEGRRRRRFLNLRFGMTSGQSPDTSEQKGKDPKDRRGDAGALDGCPTQEDDTKDREVAVEGQRKDKKETTGYMSEKTTQKNMRENYYSMEKDIPGKIDLKTDRHQKKKKQDKKQEKQTKLLQQRGEHTTGLRWEDSWEEVESLEIGIARLSLKDTPEENMEVNIQVPSAKLEGELTLADKDVVAKDSKFKMPKFKMPSFGVSAPGKPSLEASLEVGAPKVEADVAPPQVQGDLKTPDLSVQLPSADLELKAGQVGVKLPEGQLPEAELPAAQAAAAAGAGLKGHLPKVQMPSLKMPKVDLKGPHVDLKGPKVDVKGAKGEVSAPDLEVSLPGVEVDIQAPGAKLEGELALADKDVAAKDSKFKMPKFKMPSFGVSAPGKPSLEASLEVGAPKVEADVAPPQVQGDLKTPDLSVQLPSADLELKAGQVGVKLPEGQLPEAELPAAQAAAAAGAGLKGHLPKVQMPSLKMPKVDLKGPHVDLKGPKVDVKGAKGEVSAPDLEVSLPGVEVDIQAPGAKLEGELALADKDVAAKDSKFKMPKFKMPSFGVSAPGKPSLEASLEVGAPKVEADVVPPQVQGDLKTPDLSVQLPSADLELKAGQVGVKLPEGQLPEAELPAAQAAAAAGAGLKGHLPKVQMPSLKMPKVDLKGPHVDLKGPKVDVKGAKGEVSAPDLEVSLPGVEVDIQAPGAKLEGELALADKDVAAKDSKFKMPKFKMPSFGVSAPGKPSLEASLEVGAPKVEADVAPPQVQGDLKTPDLSVQLPSADLELKAGQVGVKLPEGQLPEAELPAAQAAAAAGAGLKGHLPKVQMPSLKMPKVDLKGPHVDLKGPKVDVKGAKGEVSAPDLEVSLPGVEVDIQAPGAKLEGELALADKDVAAKDSKFKMPEFKMPSFGVSAPGKPSLEASLEVGAPKVEADVAPPQVQGDLKTPDLSVQLPSADLELKARQVGVKLPEGQLPEAELPAAQAAAAGAGLKGHLPKVQMPSLKMPKVDLKGPHVDLKGPKVDVKGAKGEVSAPDLEVSLPGVEVDIQAPGAKLEGELALADKDVAAKDSKFKMPKFKMPSFGVSAPGKPSLEASLEVGAPKVEADVAPPQVQGDLKTPDLSVQLPSADLELKAGQVGVKLPEGQLPEAELPAAQAAAAAGAGLKGHLPKVQMPSLKMPKVDLKGPHVDLKGPKVDVKGAKGEVSAPDLEVSLPGVEVDIQAPGAKLEGELALADKDVAAKDSKFKMPKFKMPSFGVSAPGKPSLEASLEVGAPKVEADVAPPQVQGDLKTPDLSVQLPSADLELKAGQVGVKLPEGQLPEAELPAAKAAAAAGAGLKGHLPKVQMPSLKMPKVDLKGPHVDLKGPKVDVKGAKGEVSAPDLEVSLPGVEVDIQAPGAKLEGELALADKDVAAKDSKFKMPKFKMPSFGVSAPGKPSQEASLEVGAPKVEADVAPPQVQGDLKTPDLSVQLRSADLELKAGQVGVKLPEGQLPEAELPAAQAAAAAGAGLKGHLPKVQMPSLKMPKVDLKGPHVDLKGPKVDVKGAKGEVSAPDLEVSLPGVEVDIQAPGAKLEGELSLADKDVAAKDSKFKMPKFKMPSFGVSAPGKPSLEASLEVGAPKVEADVAPPQVQGDLKTPDLSVQLRSADLELKAGQVGVKLPEGQLPEAELPAAQAAAAAGAGLKGHLPKVQMPSLKMPKVDLKGPHVDLKGPKVDVKGAKGEVSAPDLEVSLPGVEVDIQAPGAKLEGELALADKDVAAKDSKFKMPKFKMPSFGVSAPGKPSLEASLEVGAPKVEADVVPPQVQGDLKTPDLSVQLPSADLELKAGQVGVKLPEGQLPEAELPAAQAAAAAGAGLKGHLPKVQMPSLKMPKVDLKGPHVDLKGPKVDVKGAKGEVSAPDLEVSLPGVEVDIQAPGAKLEGELALADKDVAAKDSKFKMPKFKMPSFGVSAPGKPSLEASLEVGAPKVEADVAPPQVQGDLKTPDLSVQLRSADLELKAGQVGVKLPEGQLPEAELPAAQAAAAAGAGLKGHLPKVQMPSLKMPKVDLKGPHVDLKGPKVDVKGAKGEVSAPDLEVSLPGVEVDIQAPGAKLEGELSLADKDVAAKDSKFKMPKFKMPSFGVSAPGKPSLEASLEVGAPKVEADVAPPQVQGDLKTPDLSVQLRSADLELKAGQVGVKLPEGQLPEAELPAAQAAAAAGAGLKGHLPKVQMPSLKMPKVDLKGPHVDLKGPKVDVKYPQVDMFDHHDSVRTPNQVGFFPFSDQVGNSRDISTSSCHDSTDAGLSPPFVPSQSLLSYVRPSLSIVDSPHESQGSTLPPFTARVLFPKFHRPKFTLSLPPSESENVLSETESQAVVHSFVTAHTLSGSVVPQVLSSDAAACSVVGVSSSQPSLSQPPEAPKQEAKDTSFKLPSVKLPSFNWSPKKAAESTGDSQSQETPTPSLSLSSMEMDSQIQSSVSIVESPQHAPLEKDVEKGRSRKLSFSMPRLALPKIKVSKGTASVPHGDMRPSLSGTTSGGDLVVVETAVSDAHVGDTHSKDVTTELHVRSPSTTAELVRSKTELPSSKDDLNVRGDSKSLMTVSASQPFGELVPPRTEGPLQPSGRQRDNACTMETPEMDPTAKETSTDSNERRFKMPKFRVPGFRRSSSKERDRLGEQEATQKSQTQVISIPLEAEEKAAACVQLSHVPESKVEAHISLETPEEGTSVKPVESPTYADVVKRDLHGTGSRMHSSTVEHSHTHLSTPEFGTHLYKDSVSLVRVSEPQLPPEETGKQQHPGPGGNIPAEMEARTGSLPSQPRGPLRLKASITDVASQVSVVSMSQLWEDSVLTVTFPKLKVPRFSFPAPSSEADVFFPVVREVEASITGPMHTGSPGLWEASILKTGAEDTRMPPASLEQSLEASPISKVRVHIQGSRGESQEVALPSRMERWSADPLAPGAFCTQIVRESEIPASTIQTPSYGFSLLKVKIPEPPVQACVYTVAPDSQPQESVGGAPSPAAAGGHSAPAEAPPDTGEPFEIISSSVGVPPGPQLADSTSDEEPAEILEFPEDSQEVKVSGMDTKQKPEGKKASLLWSWLPSIGFSSVEEMAAESRDTTQRSPVHVQPTARLDPELPRKQEKAGWFRFPKLGFSSSPTKKPRNTEDGEGQEEHKPQEETVTFFDARESFSPEEEEEAKSEGTSARPGSEAMVASSARTELVLLEQARDTGDKPIPRPVAK", "length": 3501 }, "evidence": [ { "id": "HGNC:20125", "url": "https://alliancegenome.org/gene/HGNC:20125#orthology", "database": "AGR" }, { "id": "MGI:2144831", "url": "https://alliancegenome.org/gene/MGI:2144831#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A8I6AAE1-1", "protein_name": "AHNAK nucleoprotein 2", "gene_name": "Ahnak2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKDHPPDGPKLEVKGAEGEVSGPELEVSLPGVEVDIQAPSVNLEGDVVLAEKDLAAKDTKFKMPKFKMPSFGVSIPGKPTMEASLEVGAPKVEGDVALPSGKGDLKTPDVSIQLPSAHLDLRAGQVGVKLAEDQPTDAETSVQAAAGVSLKGHLPKVQMPSLKMPKVDVKGPHVDLKDPKVDVTGVKGEVRSPDLEVTLPGVEVDIQAPAAKVEGDKALGDKDLATKDSKFKMPKFKMPSFRVSAHGKPTVEASLEVGAPKVEGDVVLPSVQGDKKTPDVSIQLPSAHLDLRAGQVGLKLAEDQPTDAETSAQAAAGASLKGHLPKVQMPSLKMPKVDVKGPHVDLKVPKVDMTGDKGEVRSPELEVALPGVEVDIQGPAAKVGGDMALGEKEVATKDSKFKMPKFKMPSFGVSVPGKPTVDASLRVGAPKVEGEVVLPSVQGDLKTPDVSMQLPSADLELRPRQEGEKLSEDLPRDAETSAQAAAGASLKGHLPKVQMPSLKVPKVDLKGPHVDVKGPKVDVKDPKVDVKGAKGEVRAPDLDVALPGVEVDIQAPCAKLEGDVLLGDQDVAGKDTKFKMPKFKMPSFSVSASGKPSVEASLEVGAPKVEGDVALPSVQGDLKTPDVSIQLPSTDLEIRAGQVGVNLMKDQPPDVETHARAAAGGGLKGHMPKVHMPSIKMPKVELKGPHVDMKGPKLEVKGAEGEVSGPELEVSLPGVEVDIQAPSVNLEGDVVLAEKDLAAKDTKFKMPKFKMPSFGVSIPGKPTMEASLEVGAPKVEGDVALPSGKGDLKTPDVSIQLPSAHLDLRAGQVGVKLAEDQPTDAETSVQAAAGVSLKGHLPKVQMPSLKMPKVDVKGPHVDLKDPKVDVTGVKGEVRSPDLEVTLPGVEVDIQAPAAKVEGDKALGDKDLATKDSKFKMPKFKMPSFRVSAHGKPTVEASLEVGAPKVEGDVVLPSVQGDKKTPDVSIQLPSAHLDLRAGQVGLKLAEDQPTDAETSAQAAAGASLKGHLPKVQMPSLKMPKVDVKGPHVDLKVPKVDMTGDKGEVRSPELEVALPGVEVDIQGPAAKVGGDMALGEKEVATKDSKFKMPKFKMPSFGVSVPGKPTVDASLRVGAPKVEGEVVLPSVQGDLKTPDVSMQLPSADLELRPRQEGEKLSEDLPRDAETSAQAAAGASLKGHLPKVQMPSLKVPKVDLKGPHVDVKGPKVDVKDPKVDVKGAKGEVRAPDLDVALPGVEVDIQAPCAKLEGDVLLGDQDVAGKDTKFKMPKFKMPSFSVSASGKPSVEASLEVGAPKVEGDVALPSVQGDLKTPDVSIQLPSTDLEIRAGQVGVNLMKDQPPDVETHARAAAGGGLKGHMPKVHMPSIKMPKVELKGPHVDMKGPKLEVKGAEGEVSGPELEVSLPGVEVDIQAPSVNLEGDVVLAEKDLAAKDTKFKMPKFKMPSFGLSAPGKPTVEASLELVAPKVERDVVLPSVKGDLKTPDVSIQLPSAHLDLRAGQVGVKLAEDQPTDAETSAQAAAGASLKGHLPKVQMPSLKMPKVDVKGPHVDLKVPKVDMTGDKGEVRSPDLEVALPGVEVDIQGPAAKVGGDMALGEKEVATKDSKFKMPKFKMPSFGVSVPGKPTVDASLRVGAPKVEGEVVLPSVQGDLKTPDVSMQLPSADLELRASQEGQKLSEDLPSDAETSAQAAAGASLKGHLPKVQMPSLKVPKVDLKGPHVDVKGPKVDVKAAKDEVRAPDLDVTLPSVEVDIQAPCAKLEGVILLGDQDVAAKDTKFKMPKFKMPSFGVSAPGKPTVEASLEVGAPKVEGDVALPSVKGDLKTTDASIQLPSAHLDLRPGQVGVKLSEDQPTDAETSAQAAAGASLKGHLPKVQMPSLKMPKVDVKGPHVDLKVPKVDMTGDKGEVRSPELEVALPGVEVDIQGPAAKVGGDMALGEKEVATKDSKFKMPKFKMPSFGVSVPGKPTVDASLRVGAPKVEGEVVLPSVQGDLKTPDVSMQLPSADLELRPRQEGEKLSEDLPRDAETSAQAAAGASLKGHLPKVQMPSLKVPKVDLKGPHVDVKGPKVDVKDPKVDVKGAKGEVRAPDLDVALPGVEVDIQAPCAKLEGDVLLGDQDVAGKDTKFKMPKFKMPSFSVSASGKPSVEASLEVGAPKVEGDVALPSVQGDLKTPDVSIQLPSTDLEIRAGQVGVNLMKDQPPDVETHARAAAGGGLKGHMPKVHMPSIKMPKVELKGPHVDMKGPKLEVKGAEGEVSGPELEVSLPGVEVDIQAPSVNLEGDVVLAEKDLAAKDTKFKMPKFKMPSFGVSTPGKPTVEASLKMGAPKVEGDVVLPSVKGDLKTPDVSIQLPSAHLDLRAGQVGVKLAEDQPTDAETSAQAAAGASLKGHLPKVQMPSLKMPKVDVKGPHVDLKVPKVDMTGDKGEVRSPDLEVALPGVEVDIQGPAAKVGGDMALGEKEVATKDSKFKMPKFKMPSFGVSVPGKPTVDASLRVGAPKVEGEVVLPSVQGDLKTPDVSMQLPSADLELRASQEGQKLSEDVPSDAETSAQAAAGASLKGHLPKVQMPSLKVPKVDLKGPHVDVKGPKVDVKAAKDEVRAPDLDVTLPSVEVDIQAPCAKLEGVILLGDQDVAAKDTKFKMPKFKMPSFGVSAPGKPTVEASLEVGAPKVEGDVALPSVKGDLKTTDASIQLPSAHLDLRPGQVGVKLSEDQPTDAETSVQAAAGVSLKGQLPKVQMPSLKMPKEDVKGPYVDLKAPKVDVTGDKGEVRSPDLEVTLPGEEVDIQAPGVKLEGDVVLAEKDLAAKDTKFKMPKFKMPSFGVSTPGKPTVEASLKMGAPKVEGDVVLPSVKGDLKTPDVSIQLPSAHLDLRAGQVGVKLAEDQPTDAETSAQAAAGASLKGHLPKVQMPSLKMPKVDVKGPHVDLKDPKVDVTGVKGEVRSPDLEVTLPGVEVDIQAPAAKVEGDKALGDKDLATKDSKFKMPKFKMPSFGVSAHGKPTVEASLEVGAPKVEGDVVLPSVQGDLKTPDVSIQLPSAHLDLRAGQVGLKLAEDQPTDAETSAQAAAGASLKGHLPKVQMPSLKMPKVDVKGPHVDLKVPKVDMTGDKGEVRSPDLEVALPGVEVDIQGPAAKVGGDMAVGEKEVATKDSKFKMPKFKMPSFGVSVPGKPTVDASLRVGAPKGEGEVVLPSVQGDLKTPDVSMQLPSADLELRASQEGVKLSEDLPSDAETSAQAAAGASLKGHLPKVQMPSLKVPKVDLKGPHVDVKGPKVDVKGPKVDMKGDKGEVRAPDLDVALPCVEVDIQAPCAKLEGDVLLGDQDVAAKDTKFKMPKFKMPSFGVSMPGKPTVESSLEVGPPKVEGDVALPSVQGDLKTPDVSIQLPSTDLEIRAGQVGVKLPDVETPAKAAVGGGLKGHLPEVQMPSLKMPKVELKGPHVDVKGPTLEVKGSQGEVSAPEFEVSLPGMEMDIQAPSVNLEGDVVLAEKDLAAKDTKFKMPKFKMPSFGVSMPGKPTVESSLEVWPPKVDGNGGLPSVQGDLKTPDVSIQLPSTNLEIRAGQVGATLTEGQPPDVEMPAKAAVGGGLKGHLPEVQMPSLTMPKVEIKGPHVDMKGPKLEVKGSQGEVSAPEFEVSVPDLEVDMQATGVKLEGDVALAEKDLAPKDTKFKMPKFKMPSFGVSASGKPTVEASLELGAPKVEGEVALPSMKGDLKTPDVSIQLPSAQVDLRVDHVGVKLAEDQPTNAETSVQAAAGVSLKGHLPKVQMPSLKMPKVDVKGPHVDLKAPHVDMTGVKGEVRSPDLEVTLPGVEVDIQVTTARLGGDMALGEKEVAAKDSKFKMPSFSVSVPRKPTVDASLELGDPKVEGDVVLPSVQGDLKTPDVSIQLPTADLELRARQEGMMLAQDQPTDAETPAQDAAGASLKAHLPKVRMPSLKMPKVDLKGPHVDVKGPKVDVKGAKGEVRAPDLDVALPCVEVEIQAPCAKLEGDVMLGDQDVAGKDSKFKMPKIKMPSFSVSMPGKPTVESSLELGAPKVEGDVALPSVQGDLKTPDVSIQLPSTDLEIRAGQVGLKLPQDQPTNVETSAQAAAGGSLKGHLPKVQMPSLKMPKVDLKGPHVDVKGPKVDVKGSKGEVRAPDLDVAVPNVEVDIQPPCAKLEGDIVLGDQDVAAKDTKFKMPKFKMPSFGVSLPGKPIMEASLEVGAPKVEGDLALPSVQGDLKTPDVSIQLPSAHLDLRARQEGVKLAEDQPTDEEAPAQAAAGASLKGHLPKVQMPSLKIPKVDVKGPHVDVKGPKVDVKAAKDKVRAPDLDVTLPGVEVDIEAPCAKLEGDVLLGDQDVAAKDTKFKMPKFKMPSFGVSVPGKPTVEASLEVGAPKVEGDVALPSVQGDLKTPDVSIQLLSAHLDLRAGQVGLKLAEDQSTDAETSAQAAAGVSLKGQLPKVQMPSLKMPKVDVKGPHVDLKVPKVDVTGVKGEVRSPELEVALPGVEVDIQGPAAKVGGDMALGEKEVATKDSKFKMPKFKMPSFSVSVPGKPTVDASLRVGAPKVEGEVVLPSVQGDLKTPDVSMQLPSADLELRASQEGVKLSEDLPSDAETSAQAAAGASLKGHLPKVQMPSLNVPKVDLKGPHVDVKGPKVDVKDPKVDVKGAKGEVRAPDLDVALPRVEVDIQAPCAKLEGDVLLGDQDVAAKDTKFKMPKFKMPSFGVSMPGKPTVESSLEVGAPKVEGDVVLPSVQGDLRTPDVSIQLPSTDLEIRAGQVGVKLPDVETPAKAAVGGGLKGHLPEVQMPSLKMPKVELKGPHVDVKGPTLEVKGAEGEVSAPELEVSLPGVEVDIQGHLPKVQMPSLKMPKFKMPSFGVSVGVPKVEGDVALPSVQGDLKTPDVSIQLPSAHLDLRAGQVGLKLAEDQSTDAETSAQAAAGVSLKGQLPKVQMPSLKMPKVDVKGPHVDLKPSKVDVTGVKGEVRSPELEVALPGVEVDIQGPAAKLGGDMALGEKEVATKDSKFKMPKFKMPSFGVSVPGKPTVDASLRVGAPKVEGEVVLPSVQGDLKTPDVSMHLPSAVLELRASQEGQKLSEDLPSDAETSAQAAAGASLKGHLPKVQMPSCKVPKVDLKGPHVDVKGPKVDVKGPKVDMKGAKGEVRAPDLDVALPRVEVDIQAPCAKLEGDVLLGDQDVAAKDTKFKMPKFKMPSFGVSMPGKPSVESSLEVGAPKVEGDVVLPSVQGDLKTPDVSIQLPSTDLEIRAGQVGVKLPDVETPAKAAVGGGLKGHLPEVQMPSLKMPKVELKGPHVDVKGPTLEVKGSQGEVSAPEFEVSLPGVEVDIQAPSVNLEGDLVLAEKDLAAKDTKFKMPKFKMPSFGVSAPGKPTVKASLEVGASKVEGDVALPSVKGDLKTPDVSIQLPSAHLDLRAGQVGLKLAEDQPTDAETSVQAAAGVSLKGQLPKVQMPSLKMPKVDVKGPHVDLKAPKVGMTGVKGEVRSPDLEVTLPGVEVDIQAPAAKVEGDKALGDKDLATKDSKFKMPKFKMPSFGVSVPGKPTVDASLHVGAPKVEGEVSLPSVPGDLKTPDISIQLPSADLELRPRQEGVKLAEDQPTDAETSVQAAAGTSLKGHLPKVQMPSLKMPKVDVKGPHVDLKAPKVDVTGVKGEVRSPELEVALSGVVVDIQGPAAKLGGDMALGEKEVATKDSKFKMPKFKMPSFGVSVPGKPTVDASLRVGAPKVEGEVVLPSVQGDLKTPDVSMQLPSADLELRASQEGQKLSEDLPSDAETSARAAAGASLKGHLPKVQMPSLKVPKVDLKGPHVDVKGPKVDVKGPKVDMKGAKGEVRAPDLDVALPRVEVDIQAPCAKLEGDVLLGDQDVAAKDTKFKMPKFKMPSFGVSMPGKPTAESSLELGAPKVEGDVALPSVQGDLKTPDVSIQLPSTDLEIRAGQVGVKLPDVETPAKAAVGGGLKGHLPEVQMPSLKMPKVELKGPHVDVKGPTLEVKGSQGEVSAPEFAVSLPGMEMDIQAPSVNLEGDVVLAEKDLAAKDTKFKMPKFKMPSFGLSAPGKPTVEASLELVAPKVEGEVALPSVKGDLKTPEVSVYLPSAHVDLRADQVGVKLAEDQLPESEMLAQAAVGTGLKGHLPKVKMPSLTMPKVDVKGPHVDLKAPQVDMTGVRGEVRSPDLEVTLPGVELDIPVTTAKLGGDMALGDKEVATKDSKFKMPKFKMPSFGVSVPRKPTVDASLELGAPKVEGDVALPSVQGDLKTPDISIQLPSADLELRARQEGMMLAQDQPTDAETPAQAAAGASLKGHLPKVQMPSLKMPKVEVKGHKVDVKGAKGEVRAPDLDVALPGVEVDIQAPCAKLEGYVVLGDQDVAAKDSKFKMPKIKMPSFSVSMPGKPTVESSLEVGAPKVEGDVALPSVQGDLKTPDVSIQLPSTDLEIRAGQMDVMVLEHQSSDVEMSAQAAADAGPKGHLPTVQIPRFKMSKVDVKGPHVEVKGPKVDVTGGNDEVGSSNREGFFHYPDDDVSHAVAAFPADGFPGAVVSPSPHTSQSFYSYVGRSSIMVDPPPGSLDSTLPQFSARILFPKFHKPKFVLSLPPSESECPPSVPEAGVHSPQASDTLSGSAAPQVPSSDASDVCILDVSSSQSLISPPPETSTLEMKDTSFKLPSIKLPSLHWSPKKTSGSKVESDSQESPLPSLGLSSAETDSEIQSEVSIVESPQHGSLDKEVDKGRGRKLSFSLPRLALPKVKVSKGSAAVPQGDLRPSLTGTTSGGDLDVIETAVSDAHFGDTHSKDVTTELHVRASSTTAELPTSETELPPPKDDLNVRGDGKSLKTVSPSQPFGELATPRTEGLPQPSGRQGDSAPTVEDLEMDPTAKEMSTDSKERRFRIPKFRVPGFRRSSSKDRDRAGEQEAPQKSQTPVIDMPSEAEETAAACMQLSHVPESKIETHISLGSPEEGTGVRPLERPTYAEVVKHDLHGTGSRMHHSTVELSRTHLPTPECGSQGSISLEVPGVRVSEPQLPPEGTGREQHPGPGGNILDEMEARTGHLASQPQGPLRLKASLTEVPSQVSVVSMSQLWEDSVLTVTFPKLKVPRFSFPAPSSEADVFFPVVREVEASIDSTVHKGSPGLWEASILKTGTEDTGMPPASPEQSSEASPISKVRVHIQGSRGESQEVAISSRVEGSSADPLVPGPLCTQIVRESEIPASTIQTPSYGFSLLKVKIPEPPMQACVYTVGPDSQEGEGGVPMPAAAGGHSIPAEVPPDTGEPFEIISSGTGMPPGPQLVDGTSDEEPAEILEFPEDSQEVKAPDTDTKQKAEGKKSSLLWSWLPSIGFSSVEETAADSRDTTQRSPVHVQPTARLDPELPRKQEKAGWFRFPKLGFSSSPTKKPRSTEDVEGQAEHKLQEETVTFFDARESFSPEEEEEAKSEVTSAGPGSEAMVTSSARTELVLLEQTRDTGDKSIPRPVAK", "length": 7434 }, "evidence": [ { "id": "HGNC:20125", "url": "https://alliancegenome.org/gene/HGNC:20125#orthology", "database": "AGR" }, { "id": "RGD:1309696", "url": "https://alliancegenome.org/gene/RGD:1309696#orthology", "database": "AGR" }, { "id": "Q8IVF2", "url": "https://omabrowser.org/oma/group/Q8IVF2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8M9Q4Z4-1", "protein_name": "Uncharacterized protein si:ch211-125o16.4", "gene_name": "si:ch211-125o16.4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MMNGETNIRVHSDGVKLDDAVKGGVGVGVKGITSPAITQGEGDKLLAATVHLDHLSKEDALQLIGIIKSYDKNLELKTSKDLKAGVSLGDLRLNSDAGLEAPGVKVNGLNGQINAPSLKGGISTPNIRGAGLDGMLGTQDVSLSTPRLHTPGVSVNVDNPELKTKTPKFQMPDFDQQAMKPKIGGDVNLTAPKVNADLKKPDLSLSGPKINGEFNTPGVDVTLPKTELTGPNMDIDTPKVNTSGKMKFPKFKKKTAKVKVPEASIDANLNKPNLELSAPKLNAGVNLPRADLEAPDVDIKTPDINIGAPKGKAKFKTLKKPTFGHKVKAPEAGLDVSASKPDLNLSAPNIDGDISIPNTRVNLPKADVDVKAPNVDIHTSSTKPKFPTLKMPKINLHKSKVKTPDLNADLNMSSPEVEMNLPKAKLDAPNLDVKAPNLNLSAPNLDIQTPGAHVQAPDIDIEAPSAKVKKPHVKMPKWSLSGPKMKGKADLDVPDLDVKAPDLNLTTPNLDVKAPDLNLSAPNLDIETPGAHVQAPDIDIEAPSAKIKKPHVKMPKLNLSGPKIKGNADLDAPDLDVKAPDLNLTAPNLNVQTPGAHVEVPDIDIEAPSAKLKKPTVNMPKINLSGPKIKGKPDLDVPNLDVKSPDLNLSAPNLDIQTPGAHVQAPDIDIEAPSAKIKKPHVKLPKFNLSGPKIKGNADLDAPDLDVKAPDLNLSAPNLDVQTPGAHVEVPDIDIEAPSAKVKKPHFNLPKMNISGPKIKGKPDLDAPNLDVNAPDLNLSAPNLDIKTPGVDVQAPDIDIEAPSAKIKKPHVKLPKFNLSGPKIKGNADLDAPDLDVKTPDLNLSAPNLDVQTPGAHVEVPDIDIEAPSAKVKKPHFNLPKINLSGPKIKGKPDLDAPNLDVNAPELNLSAPNLDIKTPGVDVQAPDIDIETPSAMVYKPHVNLPKINLSGPKVKGKPDLDAPTLDVNAPDLNLSAPGVDVQAPEIDIEAPSAKIKKPFINLPKVNLKGAKMKGPDIDLNTQADLQGPDIDLKAPNLNLSAPKVNLPDANIKSPNVDLETPGIDLNVPEVDIDAPSGKVKIPHYKMPKFGLSGPRVKTEKVEVPDVDLNIPKAELKGLNAGVKSPDLSLSTPKIKGDISAPSLNVGLPDADLKAPTANIGGSLESPNLNISKPNVDLNLPKAEFQGPDANLKVPDVDINAPSAKPKMPHFKLPKLNLSAQKMKGPELDANTDLNLSAPKLGELKTPAVDLNLPKADVNATLPKAEVSVPNVDIKSPDLESPSVKLKQLKIKKPKADLSVPKVQTSGIDINAEAPDLNLSAPKIGTPDADLSLPNAGVDVDVPTLDADVKVPKGKLKFPTMRKLNFSGPKVKSPDDDIAADVSRPDLNLSPPGVDVNLPNTGVDVDVPSINAEVEGSKSKKKWPFNWRRSVESKDGNIKIKAPEVDGNTEIKLPKNIPLFKTHSLPASNIDSILQERIGAADVTIDPAKTITDAVVSVSSVKTNLKASSPSAGVNGQRGSVDVLERLRLSNARTISQDFGISSEPGSPPKVNRGTFKVTNPDANKDHPVVDTTSNDKDAKLSLSLNNMLCLQTE", "length": 1593 }, "evidence": [ { "id": "HGNC:20125", "url": "https://alliancegenome.org/gene/HGNC:20125#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-131120-100", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-131120-100#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q8IVF2", "url": "https://www.uniprot.org/uniprotkb/Q8IVF2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q8IVF2", "url": "https://www.uniprot.org/uniprotkb/Q8IVF2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q8IVF2", "url": "https://www.uniprot.org/uniprotkb/Q8IVF2" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q8IVF2", "url": "https://www.uniprot.org/uniprotkb/Q8IVF2" } ], "pmid": "" }, { "name": "sarcolemma", "id": "GO:0042383", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042383", "evidence": [ { "database": "UniProtKB", "id": "Q8IVF2", "url": "https://www.uniprot.org/uniprotkb/Q8IVF2" } ], "pmid": "" }, { "name": "T-tubule", "id": "GO:0030315", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030315", "evidence": [ { "database": "UniProtKB", "id": "Q8IVF2", "url": "https://www.uniprot.org/uniprotkb/Q8IVF2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of RNA splicing", "id": "GO:0043484", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043484", "evidence": [ { "database": "UniProtKB", "id": "Q8IVF2", "url": "https://www.uniprot.org/uniprotkb/Q8IVF2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 4655, "end_pos": 4657, "annotation": "n_glycosylation_sequon" }, { "start_pos": 644, "end_pos": 646, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "4cn0", "pdb_chain": "a/b", "start_pos": 108, "end_pos": 203, "overlap": "1.0", "method": "X-Ray_Crystallography", "type": "experimental", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/4cn0.pdb", "url_external": "https://www.rcsb.org/structure/4cn0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q8IVF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8IVF2" }, { "id": "PRU00143", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00143" } ], "ann_type": 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