[ { "uniprot_canonical_ac": "Q5T4S7-1", "uniprot_ac": "Q5T4S7", "uniprot_id": "UBR4_HUMAN", "mass": { "chemical_mass": 573841.0, "monoisotopic_mass": 573841.0 }, "refseq": { "ac": "NP_065816", "name": "E3 ubiquitin-protein ligase UBR4", "summary": "The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065816" }, "gene_names": [ { "name": "UBR4", "type": "recommended", "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ] }, { "name": "KIAA0462", "type": "synonym", "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ] }, { "name": "KIAA1307", "type": "synonym", "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ] }, { "name": "RBAF600", "type": "synonym", "evidence": [ { "id": "NP_065816", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065816" }, { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ] }, { "name": "UBR4", "type": "synonym", "evidence": [ { "id": "NP_065816", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065816" } ] }, { "name": "ZUBR1", "type": "synonym", "evidence": [ { "id": "NP_065816", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065816" } ] }, { "name": "p600", "type": "synonym", "evidence": [ { "id": "NP_065816", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065816" } ] } ], "protein_names": [ { "name": "E3 ubiquitin-protein ligase UBR4", "type": "recommended", "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7/entry#names_and_taxonomy" } ] }, { "name": "2.3.2.27", "type": "synonym", "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7/entry#names_and_taxonomy" } ] }, { "name": "600 kDa retinoblastoma protein-associated factor", "type": "synonym", "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7/entry#names_and_taxonomy" } ] }, { "name": "E3 ubiquitin-protein ligase UBR4", "type": "synonym", "evidence": [ { "id": "NP_065816", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065816" } ] }, { "name": "N-recognin-4", "type": "synonym", "evidence": [ { "id": "NP_065816", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065816" }, { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7/entry#names_and_taxonomy" } ] }, { "name": "RBAF600", "type": "synonym", "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7/entry#names_and_taxonomy" } ] }, { "name": "RING-type E3 ubiquitin transferase UBR4", "type": "synonym", "evidence": [ { "id": "NP_065816", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065816" } ] }, { "name": "Retinoblastoma-associated factor of 600 kDa", "type": "synonym", "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7/entry#names_and_taxonomy" } ] }, { "name": "p600", "type": "synonym", "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7/entry#names_and_taxonomy" } ] }, { "name": "retinoblastoma-associated factor 600-like protein", "type": "synonym", "evidence": [ { "id": "NP_065816", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065816" } ] }, { "name": "retinoblastoma-associated factor of 600 kDa", "type": "synonym", "evidence": [ { "id": "NP_065816", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065816" } ] }, { "name": "zinc finger UBR1-type protein 1", "type": "synonym", "evidence": [ { "id": "NP_065816", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065816" } ] } ], "function": [ { "annotation": "E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the silencing factor of the integrated stress response (SIFI) complex, a multiprotein complex that turns off the mitochondrial stress response after a specific stress event has been resolved (PubMed:38297121, PubMed:40328314, PubMed:40875847). The SIFI complex ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors such as ABHD10 (PubMed:38297121, PubMed:40328314). Within the SIFI complex, UBR4 initiates ubiquitin chains that are further elongated or branched by KCMF1 (PubMed:38297121, PubMed:40328314, PubMed:40875847). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886).", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7#function" }, { "database": "PubMed", "id": "16214886", "url": "https://glygen.org/publication/PubMed/16214886" }, { "database": "PubMed", "id": "23932781", "url": "https://glygen.org/publication/PubMed/23932781" }, { "database": "PubMed", "id": "37891180", "url": "https://glygen.org/publication/PubMed/37891180" }, { "database": "PubMed", "id": "29033132", "url": "https://glygen.org/publication/PubMed/29033132" }, { "database": "PubMed", "id": "34893540", "url": "https://glygen.org/publication/PubMed/34893540" }, { "database": "PubMed", "id": "38182926", "url": "https://glygen.org/publication/PubMed/38182926" }, { "database": "PubMed", "id": "38030679", "url": "https://glygen.org/publication/PubMed/38030679" }, { "database": "PubMed", "id": "25582440", "url": "https://glygen.org/publication/PubMed/25582440" }, { "database": "PubMed", "id": "38297121", "url": "https://glygen.org/publication/PubMed/38297121" }, { "database": "PubMed", "id": "40328314", "url": "https://glygen.org/publication/PubMed/40328314" }, { "database": "PubMed", "id": "40875847", "url": "https://glygen.org/publication/PubMed/40875847" } ] }, { "annotation": "IKZF1 and UBR4 gene variants drive autoimmunity and Th2 polarization in IgG4-related disease. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_065816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065816" }, { "database": "PubMed", "id": "38885295", "url": "https://glygen.org/publication/PubMed/38885295" } ] }, { "annotation": "P600 is a cellular target of the human papillomavirus type 16 E7 oncoprotein that regulates cellular pathways that contribute to anchorage-independent growth and cellular transformation. GeneRIF: Human papillomavirus E7 oncoprotein associates with p600; interaction strongly contributes to cellular transformation independent of ability of E7 to bind pRB.", "evidence": [ { "database": "RefSeq", "id": "NP_065816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065816" }, { "database": "PubMed", "id": "16061792", "url": "https://glygen.org/publication/PubMed/16061792" } ] }, { "annotation": "Results identify and characterize p600, a unique 600-kDa retinoblastoma protein- and calmodulin-binding protein. Erratum:[Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17882]", "evidence": [ { "database": "RefSeq", "id": "NP_065816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065816" }, { "database": "PubMed", "id": "16214886", "url": "https://glygen.org/publication/PubMed/16214886" } ] }, { "annotation": "The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010].", "evidence": [ { "database": "RefSeq", "id": "NP_065816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065816" } ] } ], "disease": [ { "disease_id": "DOID:0050996", "recommended_name": { "id": "DOID:0050996", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0050996", "name": "episodic ataxia type 8", "description": "An episodic ataxia that is characterized by weakness, dysarthria and myokymia, and has_material_basis_in autosomal dominant inheritance of mutation in the UBR4 gene." }, "synonyms": [ { "id": "MONDO:0014476", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014476", "name": "episodic ataxia type 8", "description": "" }, { "id": "MONDO:0014476", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014476", "name": "episodic ataxia type 8", "description": "" }, { "id": "MONDO:0014476", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014476", "name": "EA8", "description": "" }, { "id": "MONDO:0014476", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014476", "name": "episodic ataxia, type 8", "description": "" }, { "id": "MIM:616055", "resource": "MIM", "url": "https://www.omim.org/entry/616055", "name": "Episodic ataxia 8", "description": "Episodic ataxia 8" } ], "unlinked_id_list": [], "evidence": [ { "id": "616055", "database": "MIM", "url": "https://www.omim.org/entry/616055" } ] }, { "disease_id": "DOID:1059", "recommended_name": { "id": "DOID:1059", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1059", "name": "intellectual disability", "description": "A specific developmental disorder that involves significant limitations both in mental functioning and in adaptive behavior such as communicating, taking care of him or herself, and social skills." }, "synonyms": [], "unlinked_id_list": [], "evidence": [ { "id": "1059", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1059" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 1670, "end_pos": 1670, "sequence_org": "E", "sequence_mut": "A", "comment": "Does not affect ability to recognize type-2 N-degrons.", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "PubMed", "id": "38030679", "url": "https://glygen.org/publication/PubMed/38030679" } ] }, { "start_pos": 1671, "end_pos": 1671, "sequence_org": "F", "sequence_mut": "A", "comment": "Does not recognize type-2 N-degrons.", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "PubMed", "id": "38030679", "url": "https://glygen.org/publication/PubMed/38030679" } ] }, { "start_pos": 1671, "end_pos": 1671, "sequence_org": "F", "sequence_mut": "I", "comment": "Does not recognize type-2 N-degrons.", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "PubMed", "id": "38030679", "url": "https://glygen.org/publication/PubMed/38030679" } ] }, { "start_pos": 1712, "end_pos": 1712, "sequence_org": "F", "sequence_mut": "A", "comment": "Reduced but not abolished ability to recognize type-2 N-degrons.", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "PubMed", "id": "38030679", "url": "https://glygen.org/publication/PubMed/38030679" } ] }, { "start_pos": 1713, "end_pos": 1713, "sequence_org": "F", "sequence_mut": "A", "comment": "Does not recognize type-2 N-degrons.", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "PubMed", "id": "38030679", "url": "https://glygen.org/publication/PubMed/38030679" } ] }, { "start_pos": 1713, "end_pos": 1713, "sequence_org": "F", "sequence_mut": "I", "comment": "Does not recognize type-2 N-degrons.", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "PubMed", "id": "38030679", "url": "https://glygen.org/publication/PubMed/38030679" } ] }, { "start_pos": 4362, "end_pos": 4362, "sequence_org": "F", "sequence_mut": "A", "comment": "Impairs ubiquitin chain elongation by the SIFI complex; when associated with A-4444 and A-4447.", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "PubMed", "id": "40875847", "url": "https://glygen.org/publication/PubMed/40875847" } ] }, { "start_pos": 4444, "end_pos": 4444, "sequence_org": "M", "sequence_mut": "A", "comment": "Impairs ubiquitin chain elongation by the SIFI complex; when associated with E-4447. Impairs ubiquitin chain elongation by the SIFI complex; when associated with A-4362 and A-4447.", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "PubMed", "id": "40328314", "url": "https://glygen.org/publication/PubMed/40328314" }, { "database": "PubMed", "id": "40875847", "url": "https://glygen.org/publication/PubMed/40875847" } ] }, { "start_pos": 4447, "end_pos": 4447, "sequence_org": "L", "sequence_mut": "A", "comment": "Impairs ubiquitin chain elongation by the SIFI complex; when associated with A-4362 and A-4444.", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "PubMed", "id": "40875847", "url": "https://glygen.org/publication/PubMed/40875847" } ] }, { "start_pos": 4447, "end_pos": 4447, "sequence_org": "L", "sequence_mut": "E", "comment": "Impairs ubiquitin chain elongation by the SIFI complex; when associated with A-4444.", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "PubMed", "id": "40328314", "url": "https://glygen.org/publication/PubMed/40328314" } ] }, { "start_pos": 4841, "end_pos": 4841, "sequence_org": "C", "sequence_mut": "A", "comment": "Abolished E3 ubiquitin-protein ligase activity.", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "PubMed", "id": "38182926", "url": "https://glygen.org/publication/PubMed/38182926" } ] }, { "start_pos": 4843, "end_pos": 4843, "sequence_org": "E", "sequence_mut": "E", "comment": "Abolished E3 ubiquitin-protein ligase activity.", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "PubMed", "id": "38182926", "url": "https://glygen.org/publication/PubMed/38182926" } ] }, { "start_pos": 4890, "end_pos": 4890, "sequence_org": "C", "sequence_mut": "A", "comment": "Abolished E3 ubiquitin-protein ligase activity.", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "PubMed", "id": "38182926", "url": "https://glygen.org/publication/PubMed/38182926" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "81.61", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000127481", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000127481" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "56.69", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000127481", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000127481" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "95.49", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000127481", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000127481" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "98.09", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000127481", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000127481" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "93.02", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000127481", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000127481" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "81.31", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000127481", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000127481" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "92.31", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000127481", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000127481" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "88.57", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000127481", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000127481" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "98.54", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000127481", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000127481" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "92.39", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000127481", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000127481" } ] } ], "expression_disease": [ { "significant": "No", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "Q5T4S7", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q5T4S7" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] } ] }, { "significant": "No", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "Q5T4S7", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q5T4S7" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Urinary bladder cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "Q5T4S7", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q5T4S7" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "11054", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11054" } ] } ] }, { "significant": "No", "trend": "down", "name": "Head and neck cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "Q5T4S7", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q5T4S7" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ], "unlinked_id_list": [ "DOID:1542" ], "evidence": [ { "id": "11934", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11934" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Lung cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "Q5T4S7", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q5T4S7" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ], "unlinked_id_list": [ "DOID:4765" ], "evidence": [ { "id": "1324", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1324" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Breast cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "Q5T4S7", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q5T4S7" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "Q5T4S7", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q5T4S7" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thyroid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3973", "DOID:0080524", "DOID:0080525" ], "evidence": [ { "id": "1781", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1781" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Kidney cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "Q5T4S7", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q5T4S7" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3675", "DOID:4455" ], "evidence": [ { "id": "263", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:263" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "Q5T4S7", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q5T4S7" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "3571", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3571" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Uterine cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:363", "evidence": [ { "database": "BioXpress", "id": "Q5T4S7", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q5T4S7" } ], "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] } ] }, { "significant": "No", "trend": "down", "name": "Esophageal cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:5041", "evidence": [ { "database": "BioXpress", "id": "Q5T4S7", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q5T4S7" } ], "disease": [ { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] } ] }, { "significant": "No", "trend": "down", "name": "Colorectal cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:9256", "evidence": [ { "database": "BioXpress", "id": "Q5T4S7", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q5T4S7" } ], "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "gene": [ { "name": "UBR4", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7", "locus": { "chromosome": "1", "start_pos": 19074510, "end_pos": 19210266, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000127481", "url": "https://www.ensembl.org/id/ENSG00000127481" } ] } } ], "crossref": [ { "id": "HGNC:30313", "url": "https://alliancegenome.org/gene/HGNC:30313", "database": "AGR", "categories": [ "Protein Classification" ] }, { "id": "Q5T4S7", "url": "https://alphafold.ebi.ac.uk/entry/Q5T4S7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSG00000127481", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000127481", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "Q5T4S7", "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/Q5T4S7", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "cd19680", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19680", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "CHEMBL4295851", "url": "https://www.ebi.ac.uk/chembl/target/inspect/CHEMBL4295851", "database": "ChEMBL", "categories": [ "Chemical" ] }, { "id": "UBR4", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=UBR4", "database": "GeneCards", "categories": [ "Organism-specific", "Gene Annotation" ] }, { "id": "23352", "url": "https://www.ncbi.nlm.nih.gov/gene/23352", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "30313", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30313", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "8B5W", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=8B5W&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "8BTL", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=8BTL&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "8J9Q", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=8J9Q&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "8J9R", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=8J9R&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "9D9Z", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9D9Z&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "9NWD", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9NWD&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "9NWE", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9NWE&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "9QWU", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9QWU&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "9QWX", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9QWX&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "9QWZ", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9QWZ&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "9QX0", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9QX0&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "1000534", "url": "https://www.iedb.org/epitope/1000534", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1000821", "url": "https://www.iedb.org/epitope/1000821", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1002536", "url": "https://www.iedb.org/epitope/1002536", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1003125", "url": "https://www.iedb.org/epitope/1003125", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1007382", "url": "https://www.iedb.org/epitope/1007382", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1008189", "url": "https://www.iedb.org/epitope/1008189", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1010874", "url": "https://www.iedb.org/epitope/1010874", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1011213", "url": "https://www.iedb.org/epitope/1011213", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1015000", "url": "https://www.iedb.org/epitope/1015000", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1015859", "url": "https://www.iedb.org/epitope/1015859", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1017584", "url": "https://www.iedb.org/epitope/1017584", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1019500", "url": "https://www.iedb.org/epitope/1019500", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1020947", "url": "https://www.iedb.org/epitope/1020947", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1023235", "url": "https://www.iedb.org/epitope/1023235", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1023659", "url": "https://www.iedb.org/epitope/1023659", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1025973", "url": "https://www.iedb.org/epitope/1025973", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1034285", "url": "https://www.iedb.org/epitope/1034285", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1037231", "url": "https://www.iedb.org/epitope/1037231", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1037463", "url": "https://www.iedb.org/epitope/1037463", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1042621", "url": "https://www.iedb.org/epitope/1042621", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1044031", "url": "https://www.iedb.org/epitope/1044031", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1045035", "url": "https://www.iedb.org/epitope/1045035", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1051506", "url": "https://www.iedb.org/epitope/1051506", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1052525", "url": "https://www.iedb.org/epitope/1052525", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1059190", "url": "https://www.iedb.org/epitope/1059190", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1061653", "url": "https://www.iedb.org/epitope/1061653", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1061654", "url": "https://www.iedb.org/epitope/1061654", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1062709", "url": "https://www.iedb.org/epitope/1062709", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1074312", "url": "https://www.iedb.org/epitope/1074312", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1081394", "url": "https://www.iedb.org/epitope/1081394", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1083641", "url": "https://www.iedb.org/epitope/1083641", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1084169", "url": "https://www.iedb.org/epitope/1084169", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1084185", "url": "https://www.iedb.org/epitope/1084185", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1084293", "url": "https://www.iedb.org/epitope/1084293", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1086412", "url": "https://www.iedb.org/epitope/1086412", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1088245", "url": "https://www.iedb.org/epitope/1088245", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1102949", "url": "https://www.iedb.org/epitope/1102949", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1105727", "url": "https://www.iedb.org/epitope/1105727", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1111500", "url": "https://www.iedb.org/epitope/1111500", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1118129", "url": "https://www.iedb.org/epitope/1118129", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1131306", "url": "https://www.iedb.org/epitope/1131306", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1131307", "url": "https://www.iedb.org/epitope/1131307", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1134320", "url": "https://www.iedb.org/epitope/1134320", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1160879", "url": "https://www.iedb.org/epitope/1160879", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1165703", "url": "https://www.iedb.org/epitope/1165703", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1168155", "url": "https://www.iedb.org/epitope/1168155", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1168156", "url": "https://www.iedb.org/epitope/1168156", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1207635", "url": "https://www.iedb.org/epitope/1207635", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1226861", "url": "https://www.iedb.org/epitope/1226861", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1283973", "url": "https://www.iedb.org/epitope/1283973", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1287579", "url": "https://www.iedb.org/epitope/1287579", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1315692", "url": "https://www.iedb.org/epitope/1315692", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1315758", "url": "https://www.iedb.org/epitope/1315758", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1316156", "url": "https://www.iedb.org/epitope/1316156", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1316662", "url": "https://www.iedb.org/epitope/1316662", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1317891", "url": "https://www.iedb.org/epitope/1317891", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1318029", "url": "https://www.iedb.org/epitope/1318029", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1319178", "url": "https://www.iedb.org/epitope/1319178", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1321441", "url": "https://www.iedb.org/epitope/1321441", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1324271", "url": "https://www.iedb.org/epitope/1324271", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1325569", "url": "https://www.iedb.org/epitope/1325569", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1326078", "url": "https://www.iedb.org/epitope/1326078", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1328012", "url": "https://www.iedb.org/epitope/1328012", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1333937", "url": "https://www.iedb.org/epitope/1333937", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1340424", "url": "https://www.iedb.org/epitope/1340424", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1340985", "url": "https://www.iedb.org/epitope/1340985", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1342815", "url": "https://www.iedb.org/epitope/1342815", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1348492", "url": "https://www.iedb.org/epitope/1348492", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1348637", "url": "https://www.iedb.org/epitope/1348637", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1349469", "url": "https://www.iedb.org/epitope/1349469", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1350577", "url": "https://www.iedb.org/epitope/1350577", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1351755", "url": "https://www.iedb.org/epitope/1351755", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1353927", "url": "https://www.iedb.org/epitope/1353927", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1355441", "url": "https://www.iedb.org/epitope/1355441", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1357715", "url": "https://www.iedb.org/epitope/1357715", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1358163", "url": "https://www.iedb.org/epitope/1358163", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1361696", "url": "https://www.iedb.org/epitope/1361696", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1362020", "url": "https://www.iedb.org/epitope/1362020", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1363299", "url": "https://www.iedb.org/epitope/1363299", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1363307", "url": "https://www.iedb.org/epitope/1363307", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1363574", "url": "https://www.iedb.org/epitope/1363574", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1368158", "url": "https://www.iedb.org/epitope/1368158", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1368512", "url": "https://www.iedb.org/epitope/1368512", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1372800", "url": "https://www.iedb.org/epitope/1372800", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1373066", "url": "https://www.iedb.org/epitope/1373066", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1373954", "url": "https://www.iedb.org/epitope/1373954", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1373958", "url": "https://www.iedb.org/epitope/1373958", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1374509", "url": "https://www.iedb.org/epitope/1374509", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1376237", "url": "https://www.iedb.org/epitope/1376237", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1376362", "url": "https://www.iedb.org/epitope/1376362", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1393623", "url": "https://www.iedb.org/epitope/1393623", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1563157", "url": "https://www.iedb.org/epitope/1563157", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1563472", "url": "https://www.iedb.org/epitope/1563472", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1567457", "url": "https://www.iedb.org/epitope/1567457", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1570383", "url": "https://www.iedb.org/epitope/1570383", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1571127", "url": "https://www.iedb.org/epitope/1571127", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1572602", "url": "https://www.iedb.org/epitope/1572602", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1573966", "url": "https://www.iedb.org/epitope/1573966", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1585446", "url": "https://www.iedb.org/epitope/1585446", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1586054", "url": "https://www.iedb.org/epitope/1586054", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1589028", "url": "https://www.iedb.org/epitope/1589028", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1593603", "url": "https://www.iedb.org/epitope/1593603", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1599370", "url": "https://www.iedb.org/epitope/1599370", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1603594", "url": "https://www.iedb.org/epitope/1603594", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1614639", "url": "https://www.iedb.org/epitope/1614639", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1621026", "url": "https://www.iedb.org/epitope/1621026", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1625641", "url": "https://www.iedb.org/epitope/1625641", "database": "IEDB", "categories": [ "Other" ] }, { "id": "162846", "url": "https://www.iedb.org/epitope/162846", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1638735", "url": "https://www.iedb.org/epitope/1638735", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1712555", "url": "https://www.iedb.org/epitope/1712555", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1713240", "url": "https://www.iedb.org/epitope/1713240", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1714464", "url": "https://www.iedb.org/epitope/1714464", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1714650", "url": "https://www.iedb.org/epitope/1714650", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1714867", "url": "https://www.iedb.org/epitope/1714867", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1716581", "url": "https://www.iedb.org/epitope/1716581", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1722547", "url": "https://www.iedb.org/epitope/1722547", "database": "IEDB", "categories": [ "Other" ] }, { "id": "175897", "url": "https://www.iedb.org/epitope/175897", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1780680", "url": "https://www.iedb.org/epitope/1780680", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1836408", "url": "https://www.iedb.org/epitope/1836408", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1852536", "url": "https://www.iedb.org/epitope/1852536", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1859831", "url": "https://www.iedb.org/epitope/1859831", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1865259", "url": "https://www.iedb.org/epitope/1865259", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1865515", "url": "https://www.iedb.org/epitope/1865515", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1866967", "url": "https://www.iedb.org/epitope/1866967", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1868443", "url": "https://www.iedb.org/epitope/1868443", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1869127", "url": "https://www.iedb.org/epitope/1869127", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1875218", "url": "https://www.iedb.org/epitope/1875218", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1875219", "url": "https://www.iedb.org/epitope/1875219", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1879356", "url": "https://www.iedb.org/epitope/1879356", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1887254", "url": "https://www.iedb.org/epitope/1887254", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1888126", "url": "https://www.iedb.org/epitope/1888126", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1889152", "url": "https://www.iedb.org/epitope/1889152", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1896431", "url": "https://www.iedb.org/epitope/1896431", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1903123", "url": "https://www.iedb.org/epitope/1903123", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1903355", "url": "https://www.iedb.org/epitope/1903355", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1903950", "url": "https://www.iedb.org/epitope/1903950", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1906669", "url": "https://www.iedb.org/epitope/1906669", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1907824", "url": "https://www.iedb.org/epitope/1907824", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1910179", "url": "https://www.iedb.org/epitope/1910179", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1911547", "url": "https://www.iedb.org/epitope/1911547", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1913318", "url": "https://www.iedb.org/epitope/1913318", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1914944", "url": "https://www.iedb.org/epitope/1914944", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1917541", "url": "https://www.iedb.org/epitope/1917541", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1919320", "url": "https://www.iedb.org/epitope/1919320", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1920091", "url": "https://www.iedb.org/epitope/1920091", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1920647", "url": "https://www.iedb.org/epitope/1920647", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1921992", "url": "https://www.iedb.org/epitope/1921992", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1926476", "url": "https://www.iedb.org/epitope/1926476", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1928199", "url": "https://www.iedb.org/epitope/1928199", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1928954", "url": "https://www.iedb.org/epitope/1928954", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1930098", "url": "https://www.iedb.org/epitope/1930098", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1932795", "url": "https://www.iedb.org/epitope/1932795", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1938990", "url": "https://www.iedb.org/epitope/1938990", "database": "IEDB", "categories": [ "Other" ] }, { "id": "194067", "url": "https://www.iedb.org/epitope/194067", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1942549", "url": "https://www.iedb.org/epitope/1942549", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1944369", "url": "https://www.iedb.org/epitope/1944369", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1968004", "url": "https://www.iedb.org/epitope/1968004", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1973173", "url": "https://www.iedb.org/epitope/1973173", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1973284", "url": "https://www.iedb.org/epitope/1973284", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1974189", "url": "https://www.iedb.org/epitope/1974189", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1975908", "url": "https://www.iedb.org/epitope/1975908", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1975944", "url": "https://www.iedb.org/epitope/1975944", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1978672", "url": "https://www.iedb.org/epitope/1978672", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1980727", "url": "https://www.iedb.org/epitope/1980727", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1980736", "url": "https://www.iedb.org/epitope/1980736", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1981265", "url": "https://www.iedb.org/epitope/1981265", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1982013", "url": "https://www.iedb.org/epitope/1982013", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1982592", "url": "https://www.iedb.org/epitope/1982592", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1982662", "url": "https://www.iedb.org/epitope/1982662", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1982747", "url": "https://www.iedb.org/epitope/1982747", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1983090", "url": "https://www.iedb.org/epitope/1983090", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1983816", "url": "https://www.iedb.org/epitope/1983816", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1983820", "url": "https://www.iedb.org/epitope/1983820", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1983968", "url": "https://www.iedb.org/epitope/1983968", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1984238", "url": "https://www.iedb.org/epitope/1984238", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1984761", "url": "https://www.iedb.org/epitope/1984761", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1984899", "url": "https://www.iedb.org/epitope/1984899", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1985523", "url": "https://www.iedb.org/epitope/1985523", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1985781", "url": "https://www.iedb.org/epitope/1985781", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1985844", "url": "https://www.iedb.org/epitope/1985844", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1987049", "url": "https://www.iedb.org/epitope/1987049", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1988190", "url": "https://www.iedb.org/epitope/1988190", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1988316", "url": "https://www.iedb.org/epitope/1988316", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1988317", "url": "https://www.iedb.org/epitope/1988317", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1988479", "url": "https://www.iedb.org/epitope/1988479", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1990952", "url": "https://www.iedb.org/epitope/1990952", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1992014", "url": "https://www.iedb.org/epitope/1992014", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1993917", "url": "https://www.iedb.org/epitope/1993917", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1995094", "url": "https://www.iedb.org/epitope/1995094", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1997223", "url": "https://www.iedb.org/epitope/1997223", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1997487", "url": "https://www.iedb.org/epitope/1997487", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1998946", "url": "https://www.iedb.org/epitope/1998946", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1999388", "url": "https://www.iedb.org/epitope/1999388", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1999391", "url": "https://www.iedb.org/epitope/1999391", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2005065", "url": "https://www.iedb.org/epitope/2005065", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2006591", "url": "https://www.iedb.org/epitope/2006591", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2007224", "url": "https://www.iedb.org/epitope/2007224", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2007387", "url": "https://www.iedb.org/epitope/2007387", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2007857", "url": "https://www.iedb.org/epitope/2007857", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2007944", "url": "https://www.iedb.org/epitope/2007944", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2008686", "url": "https://www.iedb.org/epitope/2008686", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2008988", "url": "https://www.iedb.org/epitope/2008988", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2010241", "url": "https://www.iedb.org/epitope/2010241", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2011120", "url": "https://www.iedb.org/epitope/2011120", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2011711", "url": "https://www.iedb.org/epitope/2011711", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2012806", "url": "https://www.iedb.org/epitope/2012806", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2013125", "url": "https://www.iedb.org/epitope/2013125", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2013670", "url": "https://www.iedb.org/epitope/2013670", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2013714", "url": "https://www.iedb.org/epitope/2013714", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2013776", "url": "https://www.iedb.org/epitope/2013776", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2015666", "url": "https://www.iedb.org/epitope/2015666", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2019155", "url": "https://www.iedb.org/epitope/2019155", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2021489", "url": "https://www.iedb.org/epitope/2021489", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2022117", "url": "https://www.iedb.org/epitope/2022117", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2022196", "url": "https://www.iedb.org/epitope/2022196", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2022703", "url": "https://www.iedb.org/epitope/2022703", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2022910", "url": "https://www.iedb.org/epitope/2022910", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2023667", "url": "https://www.iedb.org/epitope/2023667", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2025237", "url": "https://www.iedb.org/epitope/2025237", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2025267", "url": "https://www.iedb.org/epitope/2025267", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2026564", "url": "https://www.iedb.org/epitope/2026564", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2026671", "url": "https://www.iedb.org/epitope/2026671", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2026956", "url": "https://www.iedb.org/epitope/2026956", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2027047", "url": "https://www.iedb.org/epitope/2027047", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2027581", "url": "https://www.iedb.org/epitope/2027581", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2028484", "url": "https://www.iedb.org/epitope/2028484", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2029523", "url": "https://www.iedb.org/epitope/2029523", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2029979", "url": "https://www.iedb.org/epitope/2029979", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2030050", "url": "https://www.iedb.org/epitope/2030050", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2030317", "url": "https://www.iedb.org/epitope/2030317", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2030637", "url": "https://www.iedb.org/epitope/2030637", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2030982", "url": "https://www.iedb.org/epitope/2030982", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2031405", "url": "https://www.iedb.org/epitope/2031405", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2033141", "url": "https://www.iedb.org/epitope/2033141", "database": "IEDB", "categories": [ "Other" ] }, { "id": "203328", "url": "https://www.iedb.org/epitope/203328", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2033429", "url": "https://www.iedb.org/epitope/2033429", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2033699", "url": "https://www.iedb.org/epitope/2033699", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2033931", "url": "https://www.iedb.org/epitope/2033931", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2034971", "url": "https://www.iedb.org/epitope/2034971", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2036086", "url": "https://www.iedb.org/epitope/2036086", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2036371", "url": "https://www.iedb.org/epitope/2036371", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2037679", "url": "https://www.iedb.org/epitope/2037679", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2037762", "url": "https://www.iedb.org/epitope/2037762", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2042253", "url": "https://www.iedb.org/epitope/2042253", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2042443", "url": "https://www.iedb.org/epitope/2042443", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2042853", "url": "https://www.iedb.org/epitope/2042853", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2042924", "url": "https://www.iedb.org/epitope/2042924", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2043103", "url": "https://www.iedb.org/epitope/2043103", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2043472", "url": "https://www.iedb.org/epitope/2043472", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2045233", "url": "https://www.iedb.org/epitope/2045233", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2045235", "url": "https://www.iedb.org/epitope/2045235", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2045346", "url": "https://www.iedb.org/epitope/2045346", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2046290", "url": "https://www.iedb.org/epitope/2046290", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2047194", "url": "https://www.iedb.org/epitope/2047194", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2047273", "url": "https://www.iedb.org/epitope/2047273", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2048266", "url": "https://www.iedb.org/epitope/2048266", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2048643", "url": "https://www.iedb.org/epitope/2048643", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2049303", "url": "https://www.iedb.org/epitope/2049303", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2049316", "url": "https://www.iedb.org/epitope/2049316", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2050382", "url": "https://www.iedb.org/epitope/2050382", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2050714", "url": "https://www.iedb.org/epitope/2050714", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2051049", "url": "https://www.iedb.org/epitope/2051049", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2051151", "url": "https://www.iedb.org/epitope/2051151", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2051930", "url": "https://www.iedb.org/epitope/2051930", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2052732", "url": "https://www.iedb.org/epitope/2052732", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2053185", "url": "https://www.iedb.org/epitope/2053185", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2053551", "url": "https://www.iedb.org/epitope/2053551", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2053906", "url": "https://www.iedb.org/epitope/2053906", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2053963", "url": "https://www.iedb.org/epitope/2053963", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2055120", "url": "https://www.iedb.org/epitope/2055120", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2055850", "url": "https://www.iedb.org/epitope/2055850", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2055890", "url": "https://www.iedb.org/epitope/2055890", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2056081", "url": "https://www.iedb.org/epitope/2056081", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2058331", "url": "https://www.iedb.org/epitope/2058331", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2058524", "url": "https://www.iedb.org/epitope/2058524", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2058609", "url": "https://www.iedb.org/epitope/2058609", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2060413", "url": "https://www.iedb.org/epitope/2060413", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2061302", "url": "https://www.iedb.org/epitope/2061302", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2061396", "url": "https://www.iedb.org/epitope/2061396", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2062096", "url": "https://www.iedb.org/epitope/2062096", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2063865", "url": "https://www.iedb.org/epitope/2063865", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2068009", "url": "https://www.iedb.org/epitope/2068009", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2068254", "url": "https://www.iedb.org/epitope/2068254", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2069665", "url": "https://www.iedb.org/epitope/2069665", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2138201", "url": "https://www.iedb.org/epitope/2138201", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2138465", "url": "https://www.iedb.org/epitope/2138465", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2138914", "url": "https://www.iedb.org/epitope/2138914", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2140354", "url": "https://www.iedb.org/epitope/2140354", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2140413", "url": "https://www.iedb.org/epitope/2140413", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2140534", "url": "https://www.iedb.org/epitope/2140534", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2140759", "url": "https://www.iedb.org/epitope/2140759", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2141973", "url": "https://www.iedb.org/epitope/2141973", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2142578", "url": "https://www.iedb.org/epitope/2142578", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2144461", "url": "https://www.iedb.org/epitope/2144461", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2177890", "url": "https://www.iedb.org/epitope/2177890", "database": "IEDB", "categories": [ "Other" ] }, { "id": "219588", "url": "https://www.iedb.org/epitope/219588", "database": "IEDB", "categories": [ "Other" ] }, { "id": "224160", "url": "https://www.iedb.org/epitope/224160", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2245261", "url": "https://www.iedb.org/epitope/2245261", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2247909", "url": "https://www.iedb.org/epitope/2247909", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2259559", "url": "https://www.iedb.org/epitope/2259559", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2261622", "url": "https://www.iedb.org/epitope/2261622", "database": "IEDB", "categories": [ "Other" ] }, { "id": "241528", "url": "https://www.iedb.org/epitope/241528", "database": "IEDB", "categories": [ "Other" ] }, { "id": "425406", "url": "https://www.iedb.org/epitope/425406", "database": "IEDB", "categories": [ "Other" ] }, { "id": "426187", "url": "https://www.iedb.org/epitope/426187", "database": "IEDB", "categories": [ "Other" ] }, { "id": "427253", "url": "https://www.iedb.org/epitope/427253", "database": "IEDB", "categories": [ "Other" ] }, { "id": "427293", "url": "https://www.iedb.org/epitope/427293", "database": "IEDB", "categories": [ "Other" ] }, { "id": "431157", "url": "https://www.iedb.org/epitope/431157", "database": "IEDB", "categories": [ "Other" ] }, { "id": "432489", "url": "https://www.iedb.org/epitope/432489", "database": "IEDB", "categories": [ "Other" ] }, { "id": "436141", "url": "https://www.iedb.org/epitope/436141", "database": "IEDB", "categories": [ "Other" ] }, { "id": "436384", "url": "https://www.iedb.org/epitope/436384", "database": "IEDB", "categories": [ "Other" ] }, { "id": "437318", "url": "https://www.iedb.org/epitope/437318", "database": "IEDB", "categories": [ "Other" ] }, { "id": "438659", "url": "https://www.iedb.org/epitope/438659", "database": "IEDB", "categories": [ "Other" ] }, { "id": "439834", "url": "https://www.iedb.org/epitope/439834", "database": "IEDB", "categories": [ "Other" ] }, { "id": "439836", "url": "https://www.iedb.org/epitope/439836", "database": "IEDB", "categories": [ "Other" ] }, { "id": "441072", "url": "https://www.iedb.org/epitope/441072", "database": "IEDB", "categories": [ "Other" ] }, { "id": "441519", "url": "https://www.iedb.org/epitope/441519", "database": "IEDB", "categories": [ "Other" ] }, { "id": "443759", "url": "https://www.iedb.org/epitope/443759", "database": "IEDB", "categories": [ "Other" ] }, { "id": "444312", "url": "https://www.iedb.org/epitope/444312", "database": "IEDB", "categories": [ "Other" ] }, { "id": "445228", "url": "https://www.iedb.org/epitope/445228", "database": "IEDB", "categories": [ "Other" ] }, { "id": "445527", "url": "https://www.iedb.org/epitope/445527", "database": "IEDB", "categories": [ "Other" ] }, { "id": "446446", "url": "https://www.iedb.org/epitope/446446", "database": "IEDB", "categories": [ "Other" ] }, { "id": "447449", "url": "https://www.iedb.org/epitope/447449", "database": "IEDB", "categories": [ "Other" ] }, { "id": "448851", "url": "https://www.iedb.org/epitope/448851", "database": "IEDB", "categories": [ "Other" ] }, { "id": "450177", "url": "https://www.iedb.org/epitope/450177", "database": "IEDB", "categories": [ "Other" ] }, { "id": "453074", "url": "https://www.iedb.org/epitope/453074", "database": "IEDB", "categories": [ "Other" ] }, { "id": "457112", "url": "https://www.iedb.org/epitope/457112", "database": "IEDB", "categories": [ "Other" ] }, { "id": "459480", "url": "https://www.iedb.org/epitope/459480", "database": "IEDB", "categories": [ "Other" ] }, { "id": "459761", "url": "https://www.iedb.org/epitope/459761", "database": "IEDB", "categories": [ "Other" ] }, { "id": "464922", "url": "https://www.iedb.org/epitope/464922", "database": "IEDB", "categories": [ "Other" ] }, { "id": "466305", "url": "https://www.iedb.org/epitope/466305", "database": "IEDB", "categories": [ "Other" ] }, { "id": "468285", "url": "https://www.iedb.org/epitope/468285", "database": "IEDB", "categories": [ "Other" ] }, { "id": "468571", "url": "https://www.iedb.org/epitope/468571", "database": "IEDB", "categories": [ "Other" ] }, { "id": "469366", "url": "https://www.iedb.org/epitope/469366", "database": "IEDB", "categories": [ "Other" ] }, { "id": "471269", "url": "https://www.iedb.org/epitope/471269", "database": "IEDB", "categories": [ "Other" ] }, { "id": "471688", "url": "https://www.iedb.org/epitope/471688", "database": "IEDB", "categories": [ "Other" ] }, { "id": "479903", "url": "https://www.iedb.org/epitope/479903", "database": "IEDB", "categories": [ "Other" ] }, { "id": "481713", "url": "https://www.iedb.org/epitope/481713", "database": "IEDB", "categories": [ "Other" ] }, { "id": "484733", "url": "https://www.iedb.org/epitope/484733", "database": "IEDB", "categories": [ "Other" ] }, { "id": "485565", "url": "https://www.iedb.org/epitope/485565", "database": "IEDB", "categories": [ "Other" ] }, { "id": "486318", "url": "https://www.iedb.org/epitope/486318", "database": "IEDB", "categories": [ "Other" ] }, { "id": "486924", "url": "https://www.iedb.org/epitope/486924", "database": "IEDB", "categories": [ "Other" ] }, { "id": "489168", "url": "https://www.iedb.org/epitope/489168", "database": "IEDB", "categories": [ "Other" ] }, { "id": "490366", "url": "https://www.iedb.org/epitope/490366", "database": "IEDB", "categories": [ "Other" ] }, { "id": "490433", "url": "https://www.iedb.org/epitope/490433", "database": "IEDB", "categories": [ "Other" ] }, { "id": "491519", "url": "https://www.iedb.org/epitope/491519", "database": "IEDB", "categories": [ "Other" ] }, { "id": "492526", "url": "https://www.iedb.org/epitope/492526", "database": "IEDB", "categories": [ "Other" ] }, { "id": "493110", "url": "https://www.iedb.org/epitope/493110", "database": "IEDB", "categories": [ "Other" ] }, { "id": "493356", "url": "https://www.iedb.org/epitope/493356", "database": "IEDB", "categories": [ "Other" ] }, { "id": "495081", "url": "https://www.iedb.org/epitope/495081", "database": "IEDB", "categories": [ "Other" ] }, { "id": "495864", "url": "https://www.iedb.org/epitope/495864", "database": "IEDB", "categories": [ "Other" ] }, { "id": "504446", "url": "https://www.iedb.org/epitope/504446", "database": "IEDB", "categories": [ "Other" ] }, { "id": "505005", "url": "https://www.iedb.org/epitope/505005", "database": "IEDB", "categories": [ "Other" ] }, { "id": "505055", "url": "https://www.iedb.org/epitope/505055", "database": "IEDB", "categories": [ "Other" ] }, { "id": "506107", "url": "https://www.iedb.org/epitope/506107", "database": "IEDB", "categories": [ "Other" ] }, { "id": "509357", "url": "https://www.iedb.org/epitope/509357", "database": "IEDB", "categories": [ "Other" ] }, { "id": "509968", "url": "https://www.iedb.org/epitope/509968", "database": "IEDB", "categories": [ "Other" ] }, { "id": "522560", "url": "https://www.iedb.org/epitope/522560", "database": "IEDB", "categories": [ "Other" ] }, { "id": "541918", "url": "https://www.iedb.org/epitope/541918", "database": "IEDB", "categories": [ "Other" ] }, { "id": "542799", "url": "https://www.iedb.org/epitope/542799", "database": "IEDB", "categories": [ "Other" ] }, { "id": "543334", "url": "https://www.iedb.org/epitope/543334", "database": "IEDB", "categories": [ "Other" ] }, { "id": "543350", "url": "https://www.iedb.org/epitope/543350", "database": "IEDB", "categories": [ "Other" ] }, { "id": "543716", "url": "https://www.iedb.org/epitope/543716", "database": "IEDB", "categories": [ "Other" ] }, { "id": "545530", "url": "https://www.iedb.org/epitope/545530", "database": "IEDB", "categories": [ "Other" ] }, { "id": "545696", "url": "https://www.iedb.org/epitope/545696", "database": "IEDB", "categories": [ "Other" ] }, { "id": "545843", "url": "https://www.iedb.org/epitope/545843", "database": "IEDB", "categories": [ "Other" ] }, { "id": "548318", "url": "https://www.iedb.org/epitope/548318", "database": "IEDB", "categories": [ "Other" ] }, { "id": "575387", "url": "https://www.iedb.org/epitope/575387", "database": "IEDB", "categories": [ "Other" ] }, { "id": "575426", "url": "https://www.iedb.org/epitope/575426", "database": "IEDB", "categories": [ "Other" ] }, { "id": "575460", "url": "https://www.iedb.org/epitope/575460", "database": "IEDB", "categories": [ "Other" ] }, { "id": "577760", "url": "https://www.iedb.org/epitope/577760", "database": "IEDB", "categories": [ "Other" ] }, { "id": "577812", "url": "https://www.iedb.org/epitope/577812", "database": "IEDB", "categories": [ "Other" ] }, { "id": "578116", "url": "https://www.iedb.org/epitope/578116", "database": "IEDB", "categories": [ "Other" ] }, { "id": "578286", "url": "https://www.iedb.org/epitope/578286", "database": "IEDB", "categories": [ "Other" ] }, { "id": "583773", "url": "https://www.iedb.org/epitope/583773", "database": "IEDB", "categories": [ "Other" ] }, { "id": "590329", "url": "https://www.iedb.org/epitope/590329", "database": "IEDB", "categories": [ "Other" ] }, { "id": "593857", "url": "https://www.iedb.org/epitope/593857", "database": "IEDB", "categories": [ "Other" ] }, { "id": "594293", "url": "https://www.iedb.org/epitope/594293", "database": "IEDB", "categories": [ "Other" ] }, { "id": "594541", "url": "https://www.iedb.org/epitope/594541", "database": "IEDB", "categories": [ "Other" ] }, { "id": "596376", "url": "https://www.iedb.org/epitope/596376", "database": "IEDB", "categories": [ "Other" ] }, { "id": "597216", "url": "https://www.iedb.org/epitope/597216", "database": "IEDB", "categories": [ "Other" ] }, { "id": "597219", "url": "https://www.iedb.org/epitope/597219", "database": "IEDB", "categories": [ "Other" ] }, { "id": "598276", "url": "https://www.iedb.org/epitope/598276", "database": "IEDB", "categories": [ "Other" ] }, { "id": "598851", "url": "https://www.iedb.org/epitope/598851", "database": "IEDB", "categories": [ "Other" ] }, { "id": "599393", "url": "https://www.iedb.org/epitope/599393", "database": "IEDB", "categories": [ "Other" ] }, { "id": "602658", "url": "https://www.iedb.org/epitope/602658", "database": "IEDB", "categories": [ "Other" ] }, { "id": "603242", "url": "https://www.iedb.org/epitope/603242", "database": "IEDB", "categories": [ "Other" ] }, { "id": "603250", "url": "https://www.iedb.org/epitope/603250", "database": "IEDB", "categories": [ "Other" ] }, { "id": "603889", "url": "https://www.iedb.org/epitope/603889", "database": "IEDB", "categories": [ "Other" ] }, { "id": "607787", "url": "https://www.iedb.org/epitope/607787", "database": "IEDB", "categories": [ "Other" ] }, { "id": "607837", "url": "https://www.iedb.org/epitope/607837", "database": "IEDB", "categories": [ "Other" ] }, { "id": "608036", "url": "https://www.iedb.org/epitope/608036", "database": "IEDB", "categories": [ "Other" ] }, { "id": "608131", "url": "https://www.iedb.org/epitope/608131", "database": "IEDB", "categories": [ "Other" ] }, { "id": "608661", "url": "https://www.iedb.org/epitope/608661", "database": "IEDB", "categories": [ "Other" ] }, { "id": "612254", "url": "https://www.iedb.org/epitope/612254", "database": "IEDB", "categories": [ "Other" ] }, { "id": "614338", "url": "https://www.iedb.org/epitope/614338", "database": "IEDB", "categories": [ "Other" ] }, { "id": "617605", "url": "https://www.iedb.org/epitope/617605", "database": "IEDB", "categories": [ "Other" ] }, { "id": "618628", "url": "https://www.iedb.org/epitope/618628", "database": "IEDB", "categories": [ "Other" ] }, { "id": "620554", "url": "https://www.iedb.org/epitope/620554", "database": "IEDB", "categories": [ "Other" ] }, { "id": "622086", "url": "https://www.iedb.org/epitope/622086", "database": "IEDB", "categories": [ "Other" ] }, { "id": "622929", "url": "https://www.iedb.org/epitope/622929", "database": "IEDB", "categories": [ "Other" ] }, { "id": "623545", "url": "https://www.iedb.org/epitope/623545", "database": "IEDB", "categories": [ "Other" ] }, { "id": "623918", "url": "https://www.iedb.org/epitope/623918", "database": "IEDB", "categories": [ "Other" ] }, { "id": "627102", "url": "https://www.iedb.org/epitope/627102", "database": "IEDB", "categories": [ "Other" ] }, { "id": "629369", "url": "https://www.iedb.org/epitope/629369", "database": "IEDB", "categories": [ "Other" ] }, { "id": "629436", "url": "https://www.iedb.org/epitope/629436", "database": "IEDB", "categories": [ "Other" ] }, { "id": "630184", "url": "https://www.iedb.org/epitope/630184", "database": "IEDB", "categories": [ "Other" ] }, { "id": "630675", "url": "https://www.iedb.org/epitope/630675", "database": "IEDB", "categories": [ "Other" ] }, { "id": "633879", "url": "https://www.iedb.org/epitope/633879", "database": "IEDB", "categories": [ "Other" ] }, { "id": "634102", "url": "https://www.iedb.org/epitope/634102", "database": "IEDB", "categories": [ "Other" ] }, { "id": "634137", "url": "https://www.iedb.org/epitope/634137", "database": "IEDB", "categories": [ "Other" ] }, { "id": "634481", "url": "https://www.iedb.org/epitope/634481", "database": "IEDB", "categories": [ "Other" ] }, { "id": "637055", "url": "https://www.iedb.org/epitope/637055", "database": "IEDB", "categories": [ "Other" ] }, { "id": "640633", "url": "https://www.iedb.org/epitope/640633", "database": "IEDB", "categories": [ "Other" ] }, { "id": "640634", "url": "https://www.iedb.org/epitope/640634", "database": "IEDB", "categories": [ "Other" ] }, { "id": "642791", "url": "https://www.iedb.org/epitope/642791", "database": "IEDB", "categories": [ "Other" ] }, { "id": "643857", "url": "https://www.iedb.org/epitope/643857", "database": "IEDB", "categories": [ "Other" ] }, { "id": "644976", "url": "https://www.iedb.org/epitope/644976", "database": "IEDB", "categories": [ "Other" ] }, { "id": "645125", "url": "https://www.iedb.org/epitope/645125", "database": "IEDB", "categories": [ "Other" ] }, { "id": "646870", "url": "https://www.iedb.org/epitope/646870", "database": "IEDB", "categories": [ "Other" ] }, { "id": "649439", "url": "https://www.iedb.org/epitope/649439", "database": "IEDB", "categories": [ "Other" ] }, { "id": "651868", "url": "https://www.iedb.org/epitope/651868", "database": "IEDB", "categories": [ "Other" ] }, { "id": "652125", "url": "https://www.iedb.org/epitope/652125", "database": "IEDB", "categories": [ "Other" ] }, { "id": "652546", "url": "https://www.iedb.org/epitope/652546", "database": "IEDB", "categories": [ "Other" ] }, { "id": "670785", "url": "https://www.iedb.org/epitope/670785", "database": "IEDB", "categories": [ "Other" ] }, { "id": "673939", "url": "https://www.iedb.org/epitope/673939", "database": "IEDB", "categories": [ "Other" ] }, { "id": "681461", "url": "https://www.iedb.org/epitope/681461", "database": "IEDB", "categories": [ "Other" ] }, { "id": "691691", "url": "https://www.iedb.org/epitope/691691", "database": "IEDB", "categories": [ "Other" ] }, { "id": "692247", "url": "https://www.iedb.org/epitope/692247", "database": "IEDB", "categories": [ "Other" ] }, { "id": "692404", "url": "https://www.iedb.org/epitope/692404", "database": "IEDB", "categories": [ "Other" ] }, { "id": "699405", "url": "https://www.iedb.org/epitope/699405", "database": "IEDB", "categories": [ "Other" ] }, { "id": "699700", "url": "https://www.iedb.org/epitope/699700", "database": "IEDB", "categories": [ "Other" ] }, { "id": "700312", "url": "https://www.iedb.org/epitope/700312", "database": "IEDB", "categories": [ "Other" ] }, { "id": "703316", "url": "https://www.iedb.org/epitope/703316", "database": "IEDB", "categories": [ "Other" ] }, { "id": "704794", "url": "https://www.iedb.org/epitope/704794", "database": "IEDB", "categories": [ "Other" ] }, { "id": "705809", "url": "https://www.iedb.org/epitope/705809", "database": "IEDB", "categories": [ "Other" ] }, { "id": "705980", "url": "https://www.iedb.org/epitope/705980", "database": "IEDB", "categories": [ "Other" ] }, { "id": "707990", "url": "https://www.iedb.org/epitope/707990", "database": "IEDB", "categories": [ "Other" ] }, { "id": "708560", "url": "https://www.iedb.org/epitope/708560", "database": "IEDB", "categories": [ "Other" ] }, { "id": "708628", "url": "https://www.iedb.org/epitope/708628", "database": "IEDB", "categories": [ "Other" ] }, { "id": "711139", "url": "https://www.iedb.org/epitope/711139", "database": "IEDB", "categories": [ "Other" ] }, { "id": "711817", "url": "https://www.iedb.org/epitope/711817", "database": "IEDB", "categories": [ "Other" ] }, { "id": "711991", "url": "https://www.iedb.org/epitope/711991", "database": "IEDB", "categories": [ "Other" ] }, { "id": "712009", "url": "https://www.iedb.org/epitope/712009", "database": "IEDB", "categories": [ "Other" ] }, { "id": "715305", "url": "https://www.iedb.org/epitope/715305", "database": "IEDB", "categories": [ "Other" ] }, { "id": "717602", "url": "https://www.iedb.org/epitope/717602", "database": "IEDB", "categories": [ "Other" ] }, { "id": "718332", "url": "https://www.iedb.org/epitope/718332", "database": "IEDB", "categories": [ "Other" ] }, { "id": "718515", "url": "https://www.iedb.org/epitope/718515", "database": "IEDB", "categories": [ "Other" ] }, { "id": "718575", "url": "https://www.iedb.org/epitope/718575", "database": "IEDB", "categories": [ "Other" ] }, { "id": "720948", "url": "https://www.iedb.org/epitope/720948", "database": "IEDB", "categories": [ "Other" ] }, { "id": "724350", "url": "https://www.iedb.org/epitope/724350", "database": "IEDB", "categories": [ "Other" ] }, { "id": "724573", "url": "https://www.iedb.org/epitope/724573", "database": "IEDB", "categories": [ "Other" ] }, { "id": "724675", "url": "https://www.iedb.org/epitope/724675", "database": "IEDB", "categories": [ "Other" ] }, { "id": "724680", "url": "https://www.iedb.org/epitope/724680", "database": "IEDB", "categories": [ "Other" ] }, { "id": "726694", "url": "https://www.iedb.org/epitope/726694", "database": "IEDB", "categories": [ "Other" ] }, { "id": "726944", "url": "https://www.iedb.org/epitope/726944", "database": "IEDB", "categories": [ "Other" ] }, { "id": "727008", "url": "https://www.iedb.org/epitope/727008", "database": "IEDB", "categories": [ "Other" ] }, { "id": "727950", "url": "https://www.iedb.org/epitope/727950", "database": "IEDB", "categories": [ "Other" ] }, { "id": "729587", "url": "https://www.iedb.org/epitope/729587", "database": "IEDB", "categories": [ "Other" ] }, { "id": "729857", "url": "https://www.iedb.org/epitope/729857", "database": "IEDB", "categories": [ "Other" ] }, { "id": "729976", "url": "https://www.iedb.org/epitope/729976", "database": "IEDB", "categories": [ "Other" ] }, { "id": "731467", "url": "https://www.iedb.org/epitope/731467", "database": "IEDB", "categories": [ "Other" ] }, { "id": "732383", "url": "https://www.iedb.org/epitope/732383", "database": "IEDB", "categories": [ "Other" ] }, { "id": "732522", "url": "https://www.iedb.org/epitope/732522", "database": "IEDB", "categories": [ "Other" ] }, { "id": "733934", "url": "https://www.iedb.org/epitope/733934", "database": "IEDB", "categories": [ "Other" ] }, { "id": "734569", "url": "https://www.iedb.org/epitope/734569", "database": "IEDB", "categories": [ "Other" ] }, { "id": "735106", "url": "https://www.iedb.org/epitope/735106", "database": "IEDB", "categories": [ "Other" ] }, { "id": "772134", "url": "https://www.iedb.org/epitope/772134", "database": "IEDB", "categories": [ "Other" ] }, { "id": "772977", "url": "https://www.iedb.org/epitope/772977", "database": "IEDB", "categories": [ "Other" ] }, { "id": "774038", "url": "https://www.iedb.org/epitope/774038", "database": "IEDB", "categories": [ "Other" ] }, { "id": "777141", "url": "https://www.iedb.org/epitope/777141", "database": "IEDB", "categories": [ "Other" ] }, { "id": "779756", "url": "https://www.iedb.org/epitope/779756", "database": "IEDB", "categories": [ "Other" ] }, { "id": "840487", "url": "https://www.iedb.org/epitope/840487", "database": "IEDB", "categories": [ "Other" ] }, { "id": "860602", "url": "https://www.iedb.org/epitope/860602", "database": "IEDB", "categories": [ "Other" ] }, { "id": "866511", "url": "https://www.iedb.org/epitope/866511", "database": "IEDB", "categories": [ "Other" ] }, { "id": "867304", "url": "https://www.iedb.org/epitope/867304", "database": "IEDB", "categories": [ "Other" ] }, { "id": "868263", "url": "https://www.iedb.org/epitope/868263", "database": "IEDB", "categories": [ "Other" ] }, { "id": "868287", "url": "https://www.iedb.org/epitope/868287", "database": "IEDB", "categories": [ "Other" ] }, { "id": "868388", "url": "https://www.iedb.org/epitope/868388", "database": "IEDB", "categories": [ "Other" ] }, { "id": "868923", "url": "https://www.iedb.org/epitope/868923", "database": "IEDB", "categories": [ "Other" ] }, { "id": "868955", "url": "https://www.iedb.org/epitope/868955", "database": "IEDB", "categories": [ "Other" ] }, { "id": "869162", "url": "https://www.iedb.org/epitope/869162", "database": "IEDB", "categories": [ "Other" ] }, { "id": "875784", "url": "https://www.iedb.org/epitope/875784", "database": "IEDB", "categories": [ "Other" ] }, { "id": "879595", "url": "https://www.iedb.org/epitope/879595", "database": "IEDB", "categories": [ "Other" ] }, { "id": "884169", "url": "https://www.iedb.org/epitope/884169", "database": "IEDB", "categories": [ "Other" ] }, { "id": "884927", "url": "https://www.iedb.org/epitope/884927", "database": "IEDB", "categories": [ "Other" ] }, { "id": "884934", "url": "https://www.iedb.org/epitope/884934", "database": "IEDB", "categories": [ "Other" ] }, { "id": "884958", "url": "https://www.iedb.org/epitope/884958", "database": "IEDB", "categories": [ "Other" ] }, { "id": "892512", "url": "https://www.iedb.org/epitope/892512", "database": "IEDB", "categories": [ "Other" ] }, { "id": "896332", "url": "https://www.iedb.org/epitope/896332", "database": "IEDB", "categories": [ "Other" ] }, { "id": "902886", "url": "https://www.iedb.org/epitope/902886", "database": "IEDB", "categories": [ "Other" ] }, { "id": "921438", "url": "https://www.iedb.org/epitope/921438", "database": "IEDB", "categories": [ "Other" ] }, { "id": "924571", "url": "https://www.iedb.org/epitope/924571", "database": "IEDB", "categories": [ "Other" ] }, { "id": "926906", "url": "https://www.iedb.org/epitope/926906", "database": "IEDB", "categories": [ "Other" ] }, { "id": "929442", "url": "https://www.iedb.org/epitope/929442", "database": "IEDB", "categories": [ "Other" ] }, { "id": "929615", "url": "https://www.iedb.org/epitope/929615", "database": "IEDB", "categories": [ "Other" ] }, { "id": "930793", "url": "https://www.iedb.org/epitope/930793", "database": "IEDB", "categories": [ "Other" ] }, { "id": "939489", "url": "https://www.iedb.org/epitope/939489", "database": "IEDB", "categories": [ "Other" ] }, { "id": "940334", "url": "https://www.iedb.org/epitope/940334", "database": "IEDB", "categories": [ "Other" ] }, { "id": "947914", "url": "https://www.iedb.org/epitope/947914", "database": "IEDB", "categories": [ "Other" ] }, { "id": "950426", "url": "https://www.iedb.org/epitope/950426", "database": "IEDB", "categories": [ "Other" ] }, { "id": "950518", "url": "https://www.iedb.org/epitope/950518", "database": "IEDB", "categories": [ "Other" ] }, { "id": "950966", "url": "https://www.iedb.org/epitope/950966", "database": "IEDB", "categories": [ "Other" ] }, { "id": "951665", "url": "https://www.iedb.org/epitope/951665", "database": "IEDB", "categories": [ "Other" ] }, { "id": "953609", "url": "https://www.iedb.org/epitope/953609", "database": "IEDB", "categories": [ "Other" ] }, { "id": "953668", "url": "https://www.iedb.org/epitope/953668", "database": "IEDB", "categories": [ "Other" ] }, { "id": "953763", "url": "https://www.iedb.org/epitope/953763", "database": "IEDB", "categories": [ "Other" ] }, { "id": "955028", "url": "https://www.iedb.org/epitope/955028", "database": "IEDB", "categories": [ "Other" ] }, { "id": "955934", "url": "https://www.iedb.org/epitope/955934", "database": "IEDB", "categories": [ "Other" ] }, { "id": "956074", "url": "https://www.iedb.org/epitope/956074", "database": "IEDB", "categories": [ "Other" ] }, { "id": "987675", "url": "https://www.iedb.org/epitope/987675", "database": "IEDB", "categories": [ "Other" ] }, { "id": "992370", "url": "https://www.iedb.org/epitope/992370", "database": "IEDB", "categories": [ "Other" ] }, { "id": "998482", "url": "https://www.iedb.org/epitope/998482", "database": "IEDB", "categories": [ "Other" ] }, { "id": "Q5T4S7", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q5T4S7*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR003126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025704", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025704", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045189", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045189", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047509", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047509", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056530", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056530", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:23352", "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:23352", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "609890", "url": "http://www.omim.org/entry/609890", "database": "MIM", "categories": [ "Other" ] }, { "id": "616055", "url": "http://www.omim.org/entry/616055", "database": "MIM", "categories": [ "Other" ] }, { "id": "Q5T4S7", "url": "https://oglcnac.org/atlas/detail/Q5T4S7", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "VHRMEEH", "url": "https://omabrowser.org/oma/group/VHRMEEH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0A0MSW0", "url": "https://www.orthodb.org/?gene=A0A0A0MSW0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q5T4S7", "url": "https://www.orthodb.org/?gene=Q5T4S7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q5TBN9", "url": "https://www.orthodb.org/?gene=Q5TBN9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "X6R960", "url": "https://www.orthodb.org/?gene=X6R960", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "X6RE05", "url": "https://www.orthodb.org/?gene=X6RE05", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21725", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21725", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21725:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21725:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00008b5w", "url": "https://www.rcsb.org/structure/pdb_00008b5w", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00008btl", "url": "https://www.rcsb.org/structure/pdb_00008btl", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00008j9q", "url": "https://www.rcsb.org/structure/pdb_00008j9q", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00008j9r", "url": "https://www.rcsb.org/structure/pdb_00008j9r", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00009d9z", "url": "https://www.rcsb.org/structure/pdb_00009d9z", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00009nwd", "url": "https://www.rcsb.org/structure/pdb_00009nwd", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00009nwe", "url": "https://www.rcsb.org/structure/pdb_00009nwe", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00009qwu", "url": "https://www.rcsb.org/structure/pdb_00009qwu", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00009qwx", "url": "https://www.rcsb.org/structure/pdb_00009qwx", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00009qwz", "url": "https://www.rcsb.org/structure/pdb_00009qwz", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00009qx0", "url": "https://www.rcsb.org/structure/pdb_00009qx0", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8B5W", "url": "https://www.rcsb.org/structure/8B5W", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8BTL", "url": "https://www.rcsb.org/structure/8BTL", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8J9Q", "url": "https://www.rcsb.org/structure/8J9Q", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8J9R", "url": "https://www.rcsb.org/structure/8J9R", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9D9Z", "url": "https://www.rcsb.org/structure/9D9Z", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9NWD", "url": "https://www.rcsb.org/structure/9NWD", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9NWE", "url": "https://www.rcsb.org/structure/9NWE", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9QWU", "url": "https://www.rcsb.org/structure/9QWU", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9QWX", "url": "https://www.rcsb.org/structure/9QWX", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9QWZ", "url": "https://www.rcsb.org/structure/9QWZ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9QX0", "url": "https://www.rcsb.org/structure/9QX0", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF02207", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02207", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF13764", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13764", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF19423", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19423", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF24079", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24079", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "Q5T4S7", "url": "https://pharos.nih.gov/targets/Q5T4S7", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR:Q5T4S7", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:Q5T4S7", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-HSA-9920588", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9920588", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_065816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065816", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0A0MSW0", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MSW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0A0MSW0-1", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MSW0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5T4S7-1", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5T4S7-2", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5T4S7-3", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5T4S7-4", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7-4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5T4S7-5", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7-5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5T4S7-6", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7-6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5TBN9", "url": "https://www.uniprot.org/uniprotkb/Q5TBN9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5TBN9-1", "url": "https://www.uniprot.org/uniprotkb/Q5TBN9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "X6R960", "url": "https://www.uniprot.org/uniprotkb/X6R960", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "X6R960-1", "url": "https://www.uniprot.org/uniprotkb/X6R960-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "X6RE05", "url": "https://www.uniprot.org/uniprotkb/X6RE05", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "X6RE05-1", "url": "https://www.uniprot.org/uniprotkb/X6RE05-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCSLIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPVSPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYINRFQDAVLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRTGSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSRTKEGVGSPKLGPGKGHQGFGVLSVILANHAIKLLTSLFQDLQVEALHKGWETDGPPAALSIMAQSTSIQRIQRLIDSVPLMNLLLTLLSTSYRKACVLQRQRKGSMSSDASASTDSNTYYEDDFSSTEEDSSQDDDSEPILGQWFEETISPSKEKAAPPPPPPPPPLESSPRVKSPSKQAPGEKGNILASRKDPELFLGLASNILNFITSSMLNSRNNFIRNYLSVSLSEHHMATLASIIKEVDKDGLKGSSDEEFAAALYHFNHSLVTSDLQSPNLQNTLLQQLGVAPFSEGPWPLYIHPQSLSVLSRLLLIWQHKASAQGDPDVPECLKVWDRFLSTMKQNALQGVVPSETEDLNVEHLQMLLLIFHNFTETGRRAILSLFVQIIQELSVNMDAQMRFVPLILARLLLIFDYLLHQYSKAPVYLFEQVQHNLLSPPFGWASGSQDSNSRRATTPLYHGFKEVEENWSKHFSSDAVPHPRFYCVLSPEASEDDLNRLDSVACDVLFSKLVKYDELYAALTALLAAGSQLDTVRRKENKNVTALEACALQYYFLILWRILGILPPSKTYINQLSMNSPEMSECDILHTLRWSSRLRISSYVNWIKDHLIKQGMKAEHASSLLELASTTKCSSVKYDVEIVEEYFARQISSFCSIDCTTILQLHEIPSLQSIYTLDAAISKVQVSLDEHFSKMAAETDPHKSSEITKNLLPATLQLIDTYASFTRAYLLQNFNEEGTTEKPSKEKLQGFAAVLAIGSSRCKANTLGPTLVQNLPSSVQTVCESWNNINTNEFPNIGSWRNAFANDTIPSESYISAVQAAHLGTLCSQSLPLAASLKHTLLSLVRLTGDLIVWSDEMNPPQVIRTLLPLLLESSTESVAEISSNSLERILGPAESDEFLARVYEKLITGCYNILANHADPNSGLDESILEECLQYLEKQLESSQARKAMEEFFSDSGELVQIMMATANENLSAKFCNRVLKFFTKLFQLTEKSPNPSLLHLCGSLAQLACVEPVRLQAWLTRMTTSPPKDSDQLDVIQENRQLLQLLTTYIVRENSQVGEGVCAVLLGTLTPMATEMLANGDGTGFPELMVVMATLASAGQGAGHLQLHNAAVDWLSRCKKYLSQKNVVEKLNANVMHGKHVMILECTCHIMSYLADVTNALSQSNGQGPSHLSVDGEERAIEVDSDWVEELAVEEEDSQAEDSDEDSLCNKLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCLALVKRTPSSGMSSTMKESAFQSEPRISESLVRHASTSSPADKAKVTISDGKVADEEKPKKSSLCRTVEGCREELQNQANFSFAPLVLDMLNFLMDAIQTNFQQASAVGSSSRAQQALSELHTVEKAVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMCVLSSPHGRRQHLAVSHEKGKITVLQLSALLKQADSSKRKLTLTRLASAPVPFTVLSLTGNPCKEDYLAVCGLKDCHVLTFSSSGSVSDHLVLHPQLATGNFIIKAVWLPGSQTELAIVTADFVKIYDLCVDALSPTFYFLLPSSKIRDVTFLFNEEGKNIIVIMSSAGYIYTQLMEEASSAQQGPFYVTNVLEINHEDLKDSNSQVAGGGVSVYYSHVLQMLFFSYCQGKSFAATISRTTLEVLQLFPINIKSSNGGSKTSPALCQWSEVMNHPGLVCCVQQTTGVPLVVMVKPDTFLIQEIKTLPAKAKIQDMVAIRHTACNEQQRTTMILLCEDGSLRIYMANVENTSYWLQPSLQPSSVISIMKPVRKRKTATITTRTSSQVTFPIDFFEHNQQLTDVEFGGNDLLQVYNAQQIKHRLNSTGMYVANTKPGGFTIEISNNNSTMVMTGMRIQIGTQAIERAPSYIEIFGRTMQLNLSRSRWFDFPFTREEALQADKKLNLFIGASVDPAGVTMIDAVKIYGKTKEQFGWPDEPPEEFPSASVSNICPSNLNQSNGTGDSDSAAPTTTSGTVLERLVVSSLEALESCFAVGPIIEKERNKNAAQELATLLLSLPAPASVQQQSKSLLASLHTSRSAYHSHKDQALLSKAVQCLNTSSKEGKDLDPEVFQRLVITARSIAIMRPNNLVHFTESKLPQMETEGMDEGKEPQKQLEGDCCSFITQLVNHFWKLHASKPKNAFLAPACLPGLTHIEATVNALVDIIHGYCTCELDCINTASKIYMQMLLCPDPAVSFSCKQALIRVLRPRNKRRHVTLPSSPRSNTPMGDKDDDDDDDADEKMQSSGIPNGGHIRQESQEQSEVDHGDFEMVSESMVLETAENVNNGNPSPLEALLAGAEGFPPMLDIPPDADDETMVELAIALSLQQDQQGSSSSALGLQSLGLSGQAPSSSSLDAGTLSDTTASAPASDDEGSTAATDGSTLRTSPADHGGSVGSESGGSAVDSVAGEHSVSGRSSAYGDATAEGHPAGPGSVSSSTGAISTTTGHQEGDGSEGEGEGETEGDVHTSNRLHMVRLMLLERLLQTLPQLRNVGGVRAIPYMQVILMLTTDLDGEDEKDKGALDNLLSQLIAELGMDKKDVSKKNERSALNEVHLVVMRLLSVFMSRTKSGSKSSICESSSLISSATAAALLSSGAVDYCLHVLKSLLEYWKSQQNDEEPVATSQLLKPHTTSSPPDMSPFFLRQYVKGHAADVFEAYTQLLTEMVLRLPYQIKKITDTNSRIPPPVFDHSWFYFLSEYLMIQQTPFVRRQVRKLLLFICGSKEKYRQLRDLHTLDSHVRGIKKLLEEQGIFLRASVVTASSGSALQYDTLISLMEHLKACAEIAAQRTINWQKFCIKDDSVLYFLLQVSFLVDEGVSPVLLQLLSCALCGSKVLAALAASSGSSSASSSSAPVAASSGQATTQSKSSTKKSKKEEKEKEKDGETSGSQEDQLCTALVNQLNKFADKETLIQFLRCFLLESNSSSVRWQAHCLTLHIYRNSSKSQQELLLDLMWSIWPELPAYGRKAAQFVDLLGYFSLKTPQTEKKLKEYSQKAVEILRTQNHILTNHPNSNIYNTLSGLVEFDGYYLESDPCLVCNNPEVPFCYIKLSSIKVDTRYTTTQQVVKLIGSHTISKVTVKIGDLKRTKMVRTINLYYNNRTVQAIVELKNKPARWHKAKKVQLTPGQTEVKIDLPLPIVASNLMIEFADFYENYQASTETLQCPRCSASVPANPGVCGNCGENVYQCHKCRSINYDEKDPFLCNACGFCKYARFDFMLYAKPCCAVDPIENEEDRKKAVSNINTLLDKADRVYHQLMGHRPQLENLLCKVNEAAPEKPQDDSGTAGGISSTSASVNRYILQLAQEYCGDCKNSFDELSKIIQKVFASRKELLEYDLQQREAATKSSRTSVQPTFTASQYRALSVLGCGHTSSTKCYGCASAVTEHCITLLRALATNPALRHILVSQGLIRELFDYNLRRGAAAMREEVRQLMCLLTRDNPEATQQMNDLIIGKVSTALKGHWANPDLASSLQYEMLLLTDSISKEDSCWELRLRCALSLFLMAVNIKTPVVVENITLMCLRILQKLIKPPAPTSKKNKDVPVEALTTVKPYCNEIHAQAQLWLKRDPKASYDAWKKCLPIRGIDGNGKAPSKSELRHLYLTEKYVWRWKQFLSRRGKRTSPLDLKLGHNNWLRQVLFTPATQAARQAACTIVEALATIPSRKQQVLDLLTSYLDELSIAGECAAEYLALYQKLITSAHWKVYLAARGVLPYVGNLITKEIARLLALEEATLSTDLQQGYALKSLTGLLSSFVEVESIKRHFKSRLVGTVLNGYLCLRKLVVQRTKLIDETQDMLLEMLEDMTTGTESETKAFMAVCIETAKRYNLDDYRTPVFIFERLCSIIYPEENEVTEFFVTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLEDDSGMELLVNNKIISLDLPVAEVYKKVWCTTNEGEPMRIVYRMRGLLGDATEEFIESLDSTTDEEEDEEEVYKMAGVMAQCGGLECMLNRLAGIRDFKQGRHLLTVLLKLFSYCVKVKVNRQQLVKLEMNTLNVMLGTLNLALVAEQESKDSGGAAVAEQVLSIMEIILDESNAEPLSEDKGNLLLTGDKDQLVMLLDQINSTFVRSNPSVLQGLLRIIPYLSFGEVEKMQILVERFKPYCNFDKYDEDHSGDDKVFLDCFCKIAAGIKNNSNGHQLKDLILQKGITQNALDYMKKHIPSAKNLDADIWKKFLSRPALPFILRLLRGLAIQHPGTQVLIGTDSIPNLHKLEQVSSDEGIGTLAENLLEALREHPDVNKKIDAARRETRAEKKRMAMAMRQKALGTLGMTTNEKGQVVTKTALLKQMEELIEEPGLTCCICREGYKFQPTKVLGIYTFTKRVALEEMENKPRKQQGYSTVSHFNIVHYDCHLAAVRLARGREEWESAALQNANTKCNGLLPVWGPHVPESAFATCLARHNTYLQECTGQREPTYQLNIHDIKLLFLRFAMEQSFSADTGGGGRESNIHLIPYIIHTVLYVLNTTRATSREEKNLQGFLEQPKEKWVESAFEVDGPYYFTVLALHILPPEQWRATRVEILRRLLVTSQARAVAPGGATRLTDKAVKDYSAYRSSLLFWALVDLIYNMFKKVPTSNTEGGWSCSLAEYIRHNDMPIYEAADKALKTFQEEFMPVETFSEFLDVAGLLSEITDPESFLKDLLNSVP", "length": 5183, "header": "sp|Q5T4S7-1|UBR4_HUMAN Isoform 1 of E3 ubiquitin-protein ligase UBR4 OS=Homo sapiens OX=9606 GN=UBR4 PE=1 SV=1 CANONICAL=Q5T4S7-1" }, "isoforms": [ { "isoform_ac": "A0A0A0MSW0-1", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7/entry#A0A0A0MSW0-1", "sequence": { "sequence": "MVRLTGDLIVWSDEMNPPQVIRTLLPLLLESSTESVAEISSNSLERILGPAESDEFLARVYEKLITGCYNILANHADPNSGLDESILEECLQYLEKQLESSQARKAMEEFFSDSGELVQIMMATANENLSAKFCNRVLKFFTKLFQLTEKSPNPSLLHLCGSLAQLACVEPVRLQAWLTRMTTSPPKDSDQLDVIQENRQLLQLLTTYIVRENSQVGEGVCAVLLGTLTPMATEMLANGDGTGFPELMVVMATLASAGQGAGHLQLHNAAVDWLSRCKKYLSQKNVVEKLNANVMHGKHVMILECTCHIMSYLADVTNALSQSNGQGPSHLSVDGEERAIEVDSDWVEELAVEEEDSQAEDSDEDSLCNKLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCLALVKRTPSSGMSSTMKESAFQSEPRISESLVRHASTSSPADKAKVTISDGKVADEEKPKKSSLCRTVEGCREELQNQANFSFAPLVLDMLNFLMDAIQTNFQQASAVGSSSRAQQALSELHTVEKAVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMCVLSSPHGRRQHLAVSHEKGKITVLQLSALLKQADSSKRKLTLTRLASAPVPFTVLSLTGNPCKEDYLAVCGLKDCHVLTFSSSGSVSDHLVLHPQLATGNFIIKAVWLPGSQTELAIVTADFVKIYDLCVDALSPTFYFLLPSSKIRDVTFLFNEEGKNIIVIMSSAGYIYTQLMEEASSAQQGPFYVTNVLEINHEDLKDSNSQVAGGGVSVYYSHVLQMLFFSYCQGKSFAATISRTTLEVLQLFPINIKSSNGGSKTSPALCQWSEVMNHPGLVCCVQQTTGVPLVVMVKPDTFLIQEIKTLPAKAKIQDMVAIRHTACNEQQRTTMILLCEDGSLRIYMANVENTSYWLQPSLQPSSVISIMKPVRKRKTATITTRTSSQVTFPIDFFEHNQQLTDVEFGGNDLLQVYNAQQIKHRLNSTGMYVANTKPGGFTIEISNNNSTMVMTGMRIQIGTQAIERAPSYIEIFGRTMQLNLSRSRWFDFPFTREEALQADKKLNLFIGASVDPAGVTMIDAVKIYGKTKEQFGWPDEPPEEFPSASVSNICPSNLNQSNGTGDSDSAAPTTTSGTVLESSETESLTKLDRLVVSSLEALESCFAVGPIIEKERNKNAAQELATLLLSLPAPASVQQQSKSLLASLHTSRSAYHSHKDQALLSKAVQCLNTSSKEGKDLDPEVFQRLVITARSIAIMRPNNLVHFTESKLPQMETEGMDEGKEPQKQLEGDCCSFITQLVNHFWKLHASKPKNAFLAPACLPGLTHIEATVNALVDIIHGYCTCELDCINTASKIYMQMLLCPDPAVSFSCKQALIRVLRPRNKRRHVTLPSSPRSNTPMGDKDDDDDDDADEKMQSSGIPNGGHIRQESQEQSEVDHGDFEMVSESMVLETAENVNNGNPSPLEALLAGAEGFPPMLDIPPDADDETMVELAIALSLQQDQQAPASDDEGSTAATDGSTLRTSPADHGGSVGSESGGSAVDSVAGEHSVSGRSSAYGDATAEGHPAGPGSVSSSTGAISTTTGHQEGDGSEGEGEGETEGDVHTSNRLHMVRLMLLERLLQTLPQLRNVGGVRAIPYMQVILMLTTDLDGEDEKDKGALDNLLSQLIAELGMDKKDVSKKNERSALNEVHLVVMRLLSVFMSRTKSGSKSSICESSSLISSATAAALLSSGAVDYCLHVLKSLLEYWKSQQNDEEPVATSQLLKPHTTSSPPDMSPFFLRQYVKGHAADVFEAYTQLLTEMVLRLPYQIKKITDTNSRIPPPVFDHSWFYFLSEYLMIQQTPFVRRQVRKLLLFICGSKEKYRQLRDLHTLDSHVRGIKKLLEEQGIFLRASVVTASSGSALQYDTLISLMEHLKACAEIAAQRTINWQKFCIKDDSVLYFLLQVSFLVDEGVSPVLLQLLSCALCGSKVLAALAASSGSSSASSSSAPVAASSGQATTQSKSSTKKSKK", "length": 2058, "header": "tr|A0A0A0MSW0-1|UBR4_HUMAN Computationally mapped isoform of E3 ubiquitin-protein ligase UBR4 OS=Homo sapiens OX=9606 GN=UBR4 PE=1 SV=2 CANONICAL=Q5T4S7-1" }, "locus": { "chromosome": "1", "start_pos": 19168055, "end_pos": 19121214, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000417040.1", "url": "https://www.ensembl.org/id/ENST00000417040.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000404897.1", "url": "https://www.ensembl.org/id/ENSP00000404897.1" } ] } }, { "isoform_ac": "Q5T4S7-1", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7/entry#Q5T4S7-1", "sequence": { "sequence": "MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCSLIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPVSPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYINRFQDAVLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRTGSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSRTKEGVGSPKLGPGKGHQGFGVLSVILANHAIKLLTSLFQDLQVEALHKGWETDGPPAALSIMAQSTSIQRIQRLIDSVPLMNLLLTLLSTSYRKACVLQRQRKGSMSSDASASTDSNTYYEDDFSSTEEDSSQDDDSEPILGQWFEETISPSKEKAAPPPPPPPPPLESSPRVKSPSKQAPGEKGNILASRKDPELFLGLASNILNFITSSMLNSRNNFIRNYLSVSLSEHHMATLASIIKEVDKDGLKGSSDEEFAAALYHFNHSLVTSDLQSPNLQNTLLQQLGVAPFSEGPWPLYIHPQSLSVLSRLLLIWQHKASAQGDPDVPECLKVWDRFLSTMKQNALQGVVPSETEDLNVEHLQMLLLIFHNFTETGRRAILSLFVQIIQELSVNMDAQMRFVPLILARLLLIFDYLLHQYSKAPVYLFEQVQHNLLSPPFGWASGSQDSNSRRATTPLYHGFKEVEENWSKHFSSDAVPHPRFYCVLSPEASEDDLNRLDSVACDVLFSKLVKYDELYAALTALLAAGSQLDTVRRKENKNVTALEACALQYYFLILWRILGILPPSKTYINQLSMNSPEMSECDILHTLRWSSRLRISSYVNWIKDHLIKQGMKAEHASSLLELASTTKCSSVKYDVEIVEEYFARQISSFCSIDCTTILQLHEIPSLQSIYTLDAAISKVQVSLDEHFSKMAAETDPHKSSEITKNLLPATLQLIDTYASFTRAYLLQNFNEEGTTEKPSKEKLQGFAAVLAIGSSRCKANTLGPTLVQNLPSSVQTVCESWNNINTNEFPNIGSWRNAFANDTIPSESYISAVQAAHLGTLCSQSLPLAASLKHTLLSLVRLTGDLIVWSDEMNPPQVIRTLLPLLLESSTESVAEISSNSLERILGPAESDEFLARVYEKLITGCYNILANHADPNSGLDESILEECLQYLEKQLESSQARKAMEEFFSDSGELVQIMMATANENLSAKFCNRVLKFFTKLFQLTEKSPNPSLLHLCGSLAQLACVEPVRLQAWLTRMTTSPPKDSDQLDVIQENRQLLQLLTTYIVRENSQVGEGVCAVLLGTLTPMATEMLANGDGTGFPELMVVMATLASAGQGAGHLQLHNAAVDWLSRCKKYLSQKNVVEKLNANVMHGKHVMILECTCHIMSYLADVTNALSQSNGQGPSHLSVDGEERAIEVDSDWVEELAVEEEDSQAEDSDEDSLCNKLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCLALVKRTPSSGMSSTMKESAFQSEPRISESLVRHASTSSPADKAKVTISDGKVADEEKPKKSSLCRTVEGCREELQNQANFSFAPLVLDMLNFLMDAIQTNFQQASAVGSSSRAQQALSELHTVEKAVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMCVLSSPHGRRQHLAVSHEKGKITVLQLSALLKQADSSKRKLTLTRLASAPVPFTVLSLTGNPCKEDYLAVCGLKDCHVLTFSSSGSVSDHLVLHPQLATGNFIIKAVWLPGSQTELAIVTADFVKIYDLCVDALSPTFYFLLPSSKIRDVTFLFNEEGKNIIVIMSSAGYIYTQLMEEASSAQQGPFYVTNVLEINHEDLKDSNSQVAGGGVSVYYSHVLQMLFFSYCQGKSFAATISRTTLEVLQLFPINIKSSNGGSKTSPALCQWSEVMNHPGLVCCVQQTTGVPLVVMVKPDTFLIQEIKTLPAKAKIQDMVAIRHTACNEQQRTTMILLCEDGSLRIYMANVENTSYWLQPSLQPSSVISIMKPVRKRKTATITTRTSSQVTFPIDFFEHNQQLTDVEFGGNDLLQVYNAQQIKHRLNSTGMYVANTKPGGFTIEISNNNSTMVMTGMRIQIGTQAIERAPSYIEIFGRTMQLNLSRSRWFDFPFTREEALQADKKLNLFIGASVDPAGVTMIDAVKIYGKTKEQFGWPDEPPEEFPSASVSNICPSNLNQSNGTGDSDSAAPTTTSGTVLERLVVSSLEALESCFAVGPIIEKERNKNAAQELATLLLSLPAPASVQQQSKSLLASLHTSRSAYHSHKDQALLSKAVQCLNTSSKEGKDLDPEVFQRLVITARSIAIMRPNNLVHFTESKLPQMETEGMDEGKEPQKQLEGDCCSFITQLVNHFWKLHASKPKNAFLAPACLPGLTHIEATVNALVDIIHGYCTCELDCINTASKIYMQMLLCPDPAVSFSCKQALIRVLRPRNKRRHVTLPSSPRSNTPMGDKDDDDDDDADEKMQSSGIPNGGHIRQESQEQSEVDHGDFEMVSESMVLETAENVNNGNPSPLEALLAGAEGFPPMLDIPPDADDETMVELAIALSLQQDQQGSSSSALGLQSLGLSGQAPSSSSLDAGTLSDTTASAPASDDEGSTAATDGSTLRTSPADHGGSVGSESGGSAVDSVAGEHSVSGRSSAYGDATAEGHPAGPGSVSSSTGAISTTTGHQEGDGSEGEGEGETEGDVHTSNRLHMVRLMLLERLLQTLPQLRNVGGVRAIPYMQVILMLTTDLDGEDEKDKGALDNLLSQLIAELGMDKKDVSKKNERSALNEVHLVVMRLLSVFMSRTKSGSKSSICESSSLISSATAAALLSSGAVDYCLHVLKSLLEYWKSQQNDEEPVATSQLLKPHTTSSPPDMSPFFLRQYVKGHAADVFEAYTQLLTEMVLRLPYQIKKITDTNSRIPPPVFDHSWFYFLSEYLMIQQTPFVRRQVRKLLLFICGSKEKYRQLRDLHTLDSHVRGIKKLLEEQGIFLRASVVTASSGSALQYDTLISLMEHLKACAEIAAQRTINWQKFCIKDDSVLYFLLQVSFLVDEGVSPVLLQLLSCALCGSKVLAALAASSGSSSASSSSAPVAASSGQATTQSKSSTKKSKKEEKEKEKDGETSGSQEDQLCTALVNQLNKFADKETLIQFLRCFLLESNSSSVRWQAHCLTLHIYRNSSKSQQELLLDLMWSIWPELPAYGRKAAQFVDLLGYFSLKTPQTEKKLKEYSQKAVEILRTQNHILTNHPNSNIYNTLSGLVEFDGYYLESDPCLVCNNPEVPFCYIKLSSIKVDTRYTTTQQVVKLIGSHTISKVTVKIGDLKRTKMVRTINLYYNNRTVQAIVELKNKPARWHKAKKVQLTPGQTEVKIDLPLPIVASNLMIEFADFYENYQASTETLQCPRCSASVPANPGVCGNCGENVYQCHKCRSINYDEKDPFLCNACGFCKYARFDFMLYAKPCCAVDPIENEEDRKKAVSNINTLLDKADRVYHQLMGHRPQLENLLCKVNEAAPEKPQDDSGTAGGISSTSASVNRYILQLAQEYCGDCKNSFDELSKIIQKVFASRKELLEYDLQQREAATKSSRTSVQPTFTASQYRALSVLGCGHTSSTKCYGCASAVTEHCITLLRALATNPALRHILVSQGLIRELFDYNLRRGAAAMREEVRQLMCLLTRDNPEATQQMNDLIIGKVSTALKGHWANPDLASSLQYEMLLLTDSISKEDSCWELRLRCALSLFLMAVNIKTPVVVENITLMCLRILQKLIKPPAPTSKKNKDVPVEALTTVKPYCNEIHAQAQLWLKRDPKASYDAWKKCLPIRGIDGNGKAPSKSELRHLYLTEKYVWRWKQFLSRRGKRTSPLDLKLGHNNWLRQVLFTPATQAARQAACTIVEALATIPSRKQQVLDLLTSYLDELSIAGECAAEYLALYQKLITSAHWKVYLAARGVLPYVGNLITKEIARLLALEEATLSTDLQQGYALKSLTGLLSSFVEVESIKRHFKSRLVGTVLNGYLCLRKLVVQRTKLIDETQDMLLEMLEDMTTGTESETKAFMAVCIETAKRYNLDDYRTPVFIFERLCSIIYPEENEVTEFFVTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLEDDSGMELLVNNKIISLDLPVAEVYKKVWCTTNEGEPMRIVYRMRGLLGDATEEFIESLDSTTDEEEDEEEVYKMAGVMAQCGGLECMLNRLAGIRDFKQGRHLLTVLLKLFSYCVKVKVNRQQLVKLEMNTLNVMLGTLNLALVAEQESKDSGGAAVAEQVLSIMEIILDESNAEPLSEDKGNLLLTGDKDQLVMLLDQINSTFVRSNPSVLQGLLRIIPYLSFGEVEKMQILVERFKPYCNFDKYDEDHSGDDKVFLDCFCKIAAGIKNNSNGHQLKDLILQKGITQNALDYMKKHIPSAKNLDADIWKKFLSRPALPFILRLLRGLAIQHPGTQVLIGTDSIPNLHKLEQVSSDEGIGTLAENLLEALREHPDVNKKIDAARRETRAEKKRMAMAMRQKALGTLGMTTNEKGQVVTKTALLKQMEELIEEPGLTCCICREGYKFQPTKVLGIYTFTKRVALEEMENKPRKQQGYSTVSHFNIVHYDCHLAAVRLARGREEWESAALQNANTKCNGLLPVWGPHVPESAFATCLARHNTYLQECTGQREPTYQLNIHDIKLLFLRFAMEQSFSADTGGGGRESNIHLIPYIIHTVLYVLNTTRATSREEKNLQGFLEQPKEKWVESAFEVDGPYYFTVLALHILPPEQWRATRVEILRRLLVTSQARAVAPGGATRLTDKAVKDYSAYRSSLLFWALVDLIYNMFKKVPTSNTEGGWSCSLAEYIRHNDMPIYEAADKALKTFQEEFMPVETFSEFLDVAGLLSEITDPESFLKDLLNSVP", "length": 5183, "header": "sp|Q5T4S7-1|UBR4_HUMAN Isoform 1 of E3 ubiquitin-protein ligase UBR4 OS=Homo sapiens OX=9606 GN=UBR4 PE=1 SV=1 CANONICAL=Q5T4S7-1" }, "locus": { "chromosome": "1", "start_pos": 19210248, "end_pos": 19074835, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000375254.8", "url": "https://www.ensembl.org/id/ENST00000375254.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000364403.3", "url": "https://www.ensembl.org/id/ENSP00000364403.3" } ] } }, { "isoform_ac": "Q5T4S7-2", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7/entry#Q5T4S7-2", "sequence": { "sequence": "MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCSLIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPVSPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYINRFQDAVLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRTGSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSRTKEGVGSPKLGPGKGHQGFGVLSVILANHAIKLLTSLFQDLQVEALHKGWETDGPPAALSIMAQSTSIQRIQRLIDSVPLMNLLLTLLSTSYRKACVLQRQRKGSMSSDASASTDSNTYYEDDFSSTEEDSSQDDDSEPILGQWFEETISPSKEKAAPPPPPPPPPLESSPRVKSPSKQAPGEKGNILASRKDPELFLGLASNILNFITSSMLNSRNNFIRNYLSVSLSEHHMATLASIIKEVDKDGLKGSSDEEFAAALYHFNHSLVTSDLQSPNLQNTLLQQLGVAPFSEGPWPLYIHPQSLSVLSRLLLIWQHKASAQGDPDVPECLKVWDRFLSTMKQNALQGVVPSETEDLNVEHLQMLLLIFHNFTETGRRAILSLFVQIIQELSVNMDAQMRFVPLILARLLLIFDYLLHQYSKAPVYLFEQVQHNLLSPPFGWASGSQDSNSRRATTPLYHGFKEVEENWSKHFSSDAVPHPRFYCVLSPEASEDDLNRLDSVACDVLFSKLVKYDELYAALTALLAAGSQLDTVRRKENKNVTALEACALQYYFLILWRILGILPPSKTYINQLSMNSPEMSECDILHTLRWSSRLRISSYVNWIKDHLIKQGMKAEHASSLLELASTTKCSSVKYDVEIVEEYFARQISSFCSIDCTTILQLHEIPSLQSIYTLDAAISKVQVSLDEHFSKMAAETDPHKSSEITKNLLPATLQLIDTYASFTRAYLLQNFNEEGTTEKPSKEKLQGFAAVLAIGSSRCKANTLGPTLVQNLPSSVQTVCESWNNINTNEFPNIGSWRNAFANDTIPSESYISAVQAAHLGTLCSQSLPLAASLKHTLLSLVRLTGDLIVWSDEMNPPQVIRTLLPLLLESSTESVAEISSNSLERILGPAESDEFLARVYEKLITGCYNILANHADPNSGLDESILEECLQYLEKQLESSQARKAMEEFFSDSGELVQIMMATANENLSAKFCNRVLKFFTKLFQLTEKSPNPSLLHLCGSLAQLACVEPVRLQAWLTRMTTSPPKDSDQLDVIQENRQLLQLLTTYIVRENSQVGEGVCAVLLGTLTPMATEMLANGDGTGFPELMVVMATLASAGQGAGHLQLHNAAVDWLSRCKKYLSQKNVVEKLNANVMHGKHVMILECTCHIMSYLADVTNALSQSNGQGPSHLSVDGEERAIEVDSDWVEELAVEEEDSQAEDSDEDSLCNKLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCLALVKRTPSSGMSSTMKESAFQSEPRISESLVRHASTSSPADKAKVTISDGKVADEEKPKKSSLCRTVEGCREELQNQANFSFAPLVLDMLNFLMDAIQTNFQQASAVGSSSRAQQALSELHTVEKAVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMCVLSSPHGRRQHLAVSHEKGKITVLQLSALLKQADSSKRKLTLTRLASAPVPFTVLSLTGNPCKEDYLAVCGLKDCHVLTFSSSGSVSDHLVLHPQLATGNFIIKAVWLPGSQTELAIVTADFVKIYDLCVDALSPTFYFLLPSSKIRDVTFLFNEEGKNIIVIMSSAGYIYTQLMEEASSAQQGPFYVTNVLEINHEDLKDSNSQVAGGGVSVYYSHVLQMLFFSYCQGKSFAATISRTTLEVLQLFPINIKSSNGGSKTSPALCQWSEVMNHPGLVCCVQQTTGVPLVVMVKPDTFLIQEIKTLPAKAKIQDMVAIRHTACNEQQRTTMILLCEDGSLRIYMANVENTSYWLQPSLQPSSVISIMKPVRKRKTATITTRTSSQVTFPIDFFEHNQQLTDVEFGGNDLLQVYNAQQIKHRLNSTGMYVANTKPGGFTIEISNNNSTMVMTGMRIQIGTQAIERAPSYIEIFGRTMQLNLSRSRWFDFPFTREEALQADKKLNLFIGASVDPAGVTMIDAVKIYGKTKEQFGWPDEPPEEFPSASVSNICPSNLNQSNGTGDSDSAAPTTTSGTVLERLVVSSLEALESCFAVGPIIEKERNKNAAQELATLLLSLPAPASVQQQSKSLLASLHTSRSAYHSHKDQALLSKAVQCLNTSSKEGKDLDPEVFQRLVITARSIAIMRPNNLVHFTESKLPQMETEGMDEGKEPQKQLEGDCCSFITQLVNHFWKLHASKPKNAFLAPACLPGLTHIEATVNALVDIIHGYCTCELDCINTASKIYMQMLLCPDPAVSFSCKQALIRVLRPRNKRRHVTLPSSPRSNTPMGDKDDDDDDDADEKMQSSGIPNGGHIRQESQEQSEVDHGDFEMVSESMVLETAENVNNGNPSPLEALLAGAEGFPPMLDIPPDADDETMVELAIALSLQQDQQGSSSSALGLQSLGLSGQAPSSSSLDAGTLSDTTASAPASDDEGSTAATDGSTLRTSPADHGGSVGSESGGSAVDSVAGEHSVSGRSSAYGDATAEGHPAGPGSVSSSTGAISTTTGHQEGDGSEGEGEGETEGDVHTSNRLHMVRLMLLERLLQTLPQLRNVGGVRAIPYMQVILMLTTDLDGEDEKDKGALDNLLSQLIAELGMDKKDVSKKNERSALNEVHLVVMRLLSVFMSRTKSGSKSSICESSSLISSATAAALLSSGAVDYCLHVLKSLLEYWKSQQNDEEPVATSQLLKPHTTSSPPDMSPFFLRQYVKGHAADVFEAYTQLLTEMVLRLPYQIKKITDTNSRIPPPVFDHSWFYFLSEYLMIQQTPFVRRQVRKLLLFICGSKEKYRQLRDLHTLDSHVRGIKKLLEEQGIFLRASVVTASSGSALQYDTLISLMEHLKACAEIAAQRTINWQKFCIKDDSVLYFLLQVSFLVDEGVSPVLLQLLSCALCGSKVLAALAASSGSSSASSSSAPVAASSGQATTQSKSSTKKSKKEEKEKEKDGETSGSQEDQLCTALVNQLNKFADKETLIQFLRCFLLESNSSSVRWQAHCLTLHIYRNSSKSQQELLLDLMWSIWPELPAYGRKAAQFVDLLGYFSLKTPQTEKKLKEYSQKAVEILRTQNHILTNHPNSNIYNTLSGLVEFDGYYLESDPCLVCNNPEVPFCYIKLSSIKVDTRYTTTQQVVKLIGSHTISKVTVKIGDLKRTKMVRTINLYYNNRTVQAIVELKNKPARWHKAKKVQLTPGQTEVKIDLPLPIVASNLMIEFADFYENYQASTETLQCPRCSASVPANPGVCGNCGENVYQCHKCRSINYDEKDPFLCNACGFCKYARFDFMLYAKPCCAVDPIENEEDRKKAVSNINTLLDKADRVYHQLMGHRPQLENLLCKVNEAAPEKPQDDSGTAGGISSTSASVNRYILQLAQEYCGDCKNSFDELSKIIQKVFASRKELLEYDLQQREAATKSSRTSVQPTFTASQYRALSVLGCGHTSSTKCYGCASAVTEHCITLLRALATNPALRHILVSQGLIRELFDYNLRRGAAAMREEVRQLMCLLTRDNPEATQQMNDLIIGKVSTALKGHWANPDLASSLQYEMLLLTDSISKEDSCWELRLRCALSLFLMAVNIKTPVVVENITLMCLRILQKLIKPPAPTSKKNKDVPVEALTTVKPYCNEIHAQAQLWLKRDPKASYDAWKKCLPIRGIDGNGKAPSKSELRHLYLTEKYVWRWKQFLSRRGKRTSPLDLKLGHNNWLRQVLFTPATQAARQAACTIVEALATIPSRKQQVLDLLTSYLDELSIAGECAAEYLALYQKLITSAHWKVYLAARGVLPYVGNLITKEIARLLALEEATLSTDLQQGYALKSLTGLLSSFVEVESIKRHFKSRLVGTVLNGYLCLRKLVVQRTKLIDETQDMLLEMLEDMTTGTESETKAFMAVCIETAKRYNLDDYRTPVFIFERLCSIIYPEENEVTEFFVTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLEDDSGMELLVNNKIISLDLPVAEVYKKVWCTTNEGEPMRIVYRMRGLLGDATEEFIESLDSTTDEEEDEEEVYKMAGVMAQCGGLECMLNRLAGIRDFKQGRHLLTVLLKLFSYCVKVKVNRQQLVKLEMNTLNVMLGTLNLALVAEQESKDSGGAAVAEQVLSIMEIILDESNAEPLSEDKGNLLLTGDKDQLVMLLDQINSTFVRSNPSVLQGLLRIIPYLSFGEVEKMQILVERFKPYCNFDKYDEDHSGDDKVFLDCFCKIAAGIKNNSNGHQLKDLILQKGITQNALDYMKKHIPSAKNLDADIWKKFLSRPALPFILRLLRGLAIQHPGTQVLIGTDSIPNLHKLEQVSSDEGIGTLAENLLEALREHPDVNKKIDAARRETRAEKKRMAMAMRQKALGTLGMTTNEKGQVVTKTALLKQMEELIEEPGLTCCICREGYKFQPTKVLGIYTFTKRVALEEMENKPRKQQGYSTVSHFNIVHYDCHLAAVRLARGREEWESAALQNANTKCNGLLPVWGPHVPESAFATCLARHNTYLQECTGQREPTYQLNIHDIKLLFLRFAMEQSFSADTGGGGRESNIHLIPYIIHTVLYVLNTTRATSREEKNLQGFLEQPKEKWVESAFEVDGPYYFTVLALHILPPEQWRATRVEILRRLLVTSQARAVAPGGATRLTDKAVKDYSAYRSSLLFWALVDLIYNMFKKQTTPTVGGIDTGSLEPCVCEKVPTSNTEGGWSCSLAEYIRHNDMPIYEAADKALKTFQEEFMPVETFSEFLDVAGLLSEITDPESFLKDLLNSVP", "length": 5204, "header": "sp|Q5T4S7-2|UBR4_HUMAN Isoform 2 of E3 ubiquitin-protein ligase UBR4 OS=Homo sapiens OX=9606 GN=UBR4 PE=1 SV=1 CANONICAL=Q5T4S7-1" }, "locus": {} }, { "isoform_ac": "Q5T4S7-3", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7/entry#Q5T4S7-3", "sequence": { "sequence": "MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCSLIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPVSPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYINRFQDAVLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRTGSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSRTKEGVGSPKLGPGKGHQGFGVLSVILANHAIKLLTSLFQDLQVEALHKGWETDGPPAALSIMAQSTSIQRIQRLIDSVPLMNLLLTLLSTSYRKACVLQRQRKGSMSSDASASTDSNTYYEDDFSSTEEDSSQDDDSEPILGQWFEETISPSKEKAAPPPPPPPPPLESSPRVKSPSKQAPGEKGNILASRKDPELFLGLASNILNFITSSMLNSRNNFIRNYLSVSLSEHHMATLASIIKEVDKDGLKGSSDEEFAAALYHFNHSLVTSDLQSPNLQNTLLQQLGVAPFSEGPWPLYIHPQSLSVLSRLLLIWQHKASAQGDPDVPECLKVWDRFLSTMKQNALQGVVPSETEDLNVEHLQMLLLIFHNFTETGRRAILSLFVQIIQELSVNMDAQMRFVPLILARLLLIFDYLLHQYSKAPVYLFEQVQHNLLSPPFGWASGSQDSNSRRATTPLYHGFKEVEENWSKHFSSDAVPHPRFYCVLSPEASEDDLNRLDSVACDVLFSKLVKYDELYAALTALLAAGSQLDTVRRKENKNVTALEACALQYYFLILWRILGILPPSKTYINQLSMNSPEMSECDILHTLRWSSRLRISSYVNWIKDHLIKQGMKAEHASSLLELASTTKCSSVKYDVEIVEEYFARQISSFCSIDCTTILQLHEIPSLQSIYTLDAAISKVQVSLDEHFSKMAAETDPHKSSEITKNLLPATLQLIDTYASFTRAYLLQNFNEEGTTEKPSKEKLQGFAAVLAIGSSRCKANTLGPTLVQNLPSSVQTVCESWNNINTNEFPNIGSWRNAFANDTIPSESYISAVQAAHLGTLCSQSLPLAASLKHTLLSLVRLTGDLIVWSDEMNPPQVIRTLLPLLLESSTESVAEISSNSLERILGPAESDEFLARVYEKLITGCYNILANHADPNSGLDESILEECLQYLEKQLESSQARKAMEEFFSDSGELVQIMMATANENLSAKFCNRVLKFFTKLFQLTEKSPNPSLLHLCGSLAQLACVEPVRLQAWLTRMTTSPPKDSDQLDVIQENRQLLQLLTTYIVRENSQVGEGVCAVLLGTLTPMATEMLANGDGTGFPELMVVMATLASAGQGAGHLQLHNAAVDWLSRCKKYLSQKNVVEKLNANVMHGKHVMILECTCHIMSYLADVTNALSQSNGQGPSHLSVDGEERAIEVDSDWVEELAVEEEDSQAEDSDEDSLCNKLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCLALVKRTPSSGMSSTMKESAFQSEPRISESLVRHASTSSPADKAKVTISDGKVADEEKPKKSSLCRTVEGCREELQNQANFSFAPLVLDMLNFLMDAIQTNFQQASAVGSSSRAQQALSELHTVEKAVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMCVLSSPHGRRQHLAVSHEKGKITVLQLSALLKQADSSKRKLTLTRLASAPVPFTVLSLTGNPCKEDYLAVCGLKDCHVLTFSSSGSVSDHLVLHPQLATGNFIIKAVWLPGSQTELAIVTADFVKIYDLCVDALSPTFYFLLPSSKIRDVTFLFNEEGKNIIVIMSSAGYIYTQLMEEASSAQQGPFYVTNVLEINHEDLKDSNSQVAGGGVSVYYSHVLQMLFFSYCQGKSFAATISRTTLEVLQLFPINIKSSNGGSKTSPALCQWSEVMNHPGLVCCVQQTTGVPLVVMVKPDTFLIQEIKTLPAKAKIQDMVAIRHTACNEQQRTTMILLCEDGSLRIYMANVENTSYWLQPSLQPSSVISIMKPVRKRKTATITTRTSSQVTFPIDFFEHNQQLTDVEFGGNDLLQVYNAQQIKHRLNSTGMYVANTKPGGFTIEISNNNSTMVMTGMRIQIGTQAIERAPSYIEIFGRTMQLNLSRSRWFDFPFTREEALQADKKLNLFIGASVDPAGVTMIDAVKIYGKTKEQFGWPDEPPEEFPSASVSNICPSNLNQSNGTGDSDSAAPTTTSGTVLESSETESLTKLDRLVVSSLEALESCFAVGPIIEKERNKNAAQELATLLLSLPAPASVQQQSKSLLASLHTSRSAYHSHKDQALLSKAVQCLNTSSKEGKDLDPEVFQRLVITARSIAIMRPNNLVHFTESKLPQMETEGMDEGKEPQKQLEGDCCSFITQLVNHFWKLHASKPKNAFLAPACLPGLTHIEATVNALVDIIHGYCTCELDCINTASKIYMQMLLCPDPAVSFSCKQALIRVLRPRNKRRHVTLPSSPRSNTPMGDKDDDDDDDADEKMQSSGIPNGGHIRQESQEQSEVDHGDFEMVSESMVLETAENVNNGNPSPLEALLAGAEGFPPMLDIPPDADDETMVELAIALSLQQDQQAPASDDEGSTAATDGSTLRTSPADHGGSVGSESGGSAVDSVAGEHSVSGRSSAYGDATAEGHPAGPGSVSSSTGAISTTTGHQEGDGSEGEGEGETEGDVHTSNRLHMVRLMLLERLLQTLPQLRNVGGVRAIPYMQVILMLTTDLDGEDEKDKGALDNLLSQLIAELGMDKKDVSKKNERSALNEVHLVVMRLLSVFMSRTKSGSKSSICESSSLISSATAAALLSSGAVDYCLHVLKSLLEYWKSQQNDEEPVATSQLLKPHTTSSPPDMSPFFLRQYVKGHAADVFEAYTQLLTEMVLRLPYQIKKITDTNSRIPPPVFDHSWFYFLSEYLMIQQTPFVRRQVRKLLLFICGSKEKYRQLRDLHTLDSHVRGIKKLLEEQGIFLRASVVTASSGSALQYDTLISLMEHLKACAEIAAQRTINWQKFCIKDDSVLYFLLQVSFLVDEGVSPVLLQLLSCALCGSKVLAALAASSGSSSASSSSAPVAASSGQATTQSKSSTKKSKKEEKEKEKDGETSGSQEDQLCTALVNQLNKFADKETLIQFLRCFLLESNSSSVRWQAHCLTLHIYRNSSKSQQELLLDLMWSIWPELPAYGRKAAQFVDLLGYFSLKTPQTEKKLKEYSQKAVEILRTQNHILTNHPNSNIYNTLSGLVEFDGYYLESDPCLVCNNPEVPFCYIKLSSIKVDTRYTTTQQVVKLIGSHTISKVTVKIGDLKRTKMVRTINLYYNNRTVQAIVELKNKPARWHKAKKVQLTPGQTEVKIDLPLPIVASNLMIEFADFYENYQASTETLQCPRCSASVPANPGVCGNCGENVYQCHKCRSINYDEKDPFLCNACGFCKYARFDFMLYAKPCCAVDPIENEEDRKKAVSNINTLLDKADRVYHQLMGHRPQLENLLCKVNEAAPEKPQDDSGTAGGISSTSASVNRYILQLAQEYCGDCKNSFDELSKIIQKVFASRKELLEYDLQQREAATKSSRTSVQPTFTASQYRALSVLGCGHTSSTKCYGCASAVTEHCITLLRALATNPALRHILVSQGLIRELFDYNLRRGAAAMREEVRQLMCLLTRDNPEATQQMNDLIIGKVSTALKGHWANPDLASSLQYEMLLLTDSISKEDSCWELRLRCALSLFLMAVNIKTPVVVENITLMCLRILQKLIKPPAPTSKKNKDVPVEALTTVKPYCNEIHAQAQLWLKRDPKASYDAWKKCLPIRGIDGNGKAPSKSELRHLYLTEKYVWRWKQFLSRRGKRTSPLDLKLGHNNWLRQVLFTPATQAARQAACTIVEALATIPSRKQQVLDLLTSYLDELSIAGECAAEYLALYQKLITSAHWKVYLAARGVLPYVGNLITKEIARLLALEEATLSTDLQQGYALKSLTGLLSSFVEVESIKRHFKSRLVGTVLNGYLCLRKLVVQRTKLIDETQDMLLEMLEDMTTGTESETKAFMAVCIETAKRYNLDDYRTPVFIFERLCSIIYPEENEVTEFFVTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLEDDSGMELLVNNKIISLDLPVAEVYKKVWCTTNEGEPMRIVYRMRGLLGDATEEFIESLDSTTDEEEDEEEVYKMAGVMAQCGGLECMLNRLAGIRDFKQGRHLLTVLLKLFSYCVKVKVNRQQLVKLEMNTLNVMLGTLNLALVAEQESKDSGGAAVAEQVLSIMEIILDESNAEPLSEDKGNLLLTGDKDQLVMLLDQINSTFVRSNPSVLQGLLRIIPYLSFGEVEKMQILVERFKPYCNFDKYDEDHSGDDKVFLDCFCKIAAGIKNNSNGHQLKDLILQKGITQNALDYMKKHIPSAKNLDADIWKKFLSRPALPFILRLLRGLAIQHPGTQVLIGTDSIPNLHKLEQVSSDEGIGTLAENLLEALREHPDVNKKIDAARRETRAEKKRMAMAMRQKALGTLGMTTNEKGQVVTKTALLKQMEELIEEPGLTCCICREGYKFQPTKVLGIYTFTKRVALEEMENKPRKQQGYSTVSHFNIVHYDCHLAAVRLARGREEWESAALQNANTKCNGLLPVWGPHVPESAFATCLARHNTYLQECTGQREPTYQLNIHDIKLLFLRFAMEQSFSADTGGGGRESNIHLIPYIIHTVLYVLNTTRATSREEKNLQGFLEQPKEKWVESAFEVDGPYYFTVLALHILPPEQWRATRVEILRRLLVTSQARAVAPGGATRLTDKAVKDYSAYRSSLLFWALVDLIYNMFKKVPTSNTEGGWSCSLAEYIRHNDMPIYEAADKALKTFQEEFMPVETFSEFLDVAGLLSEITDPESFLKDLLNSVP", "length": 5159, "header": "sp|Q5T4S7-3|UBR4_HUMAN Isoform 3 of E3 ubiquitin-protein ligase UBR4 OS=Homo sapiens OX=9606 GN=UBR4 PE=1 SV=1 CANONICAL=Q5T4S7-1" }, "locus": {} }, { "isoform_ac": "Q5T4S7-4", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7/entry#Q5T4S7-4", "sequence": { "sequence": "MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCSLIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPVSPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYINRFQDAVLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRTGSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSRTKEGVGSPKLGPGKGHQGFGVLSVILANHAIKLLTSLFQDLQVEALHKGWETDGPPAALSIMAQSTSIQRIQRLIDSVPLMNLLLTLLSTSYRKACVLQRQRKGSMSSDASASTDSNTYYEDDFSSTEEDSSQDDDSEPILGQWFEETISPSKEKAAPPPPPPPPPLESSPRVKSPSKQAPGEKGNILASRKDPELFLGLASNILNFITSSMLNSRNNFIRNYLSVSLSEHHMATLASIIKEVDKDGLKGSSDEEFAAALYHFNHSLVTSDLQSPNLQNTLLQQLGVAPFSEGPWPLYIHPQSLSVLSRLLLIWQHKASAQGDPDVPECLKVWDRFLSTMKQNALQGVVPSETEDLNVEHLQMLLLIFHNFTETGRRAILSLFVQIIQELSVNMDAQMRFVPLILARLLLIFDYLLHQYSKAPVYLFEQVQHNLLSPPFGWASGSQDSNSRRATTPLYHGFKEVEENWSKHFSSDAVPHPRFYCVLSPEASEDDLNRLDSVACDVLFSKLVKYDELYAALTALLAAGSQLDTVRRKENKNVTALEACALQYYFLILWRILGILPPSKTYINQLSMNSPEMSECDILHTLRWSSRLRISSYVNWIKDHLIKQGMKAEHASSLLELASTTKCSSVKYDVEIVEEYFARQISSFCSIDCTTILQLHEIPSLQSIYTLDAAISKVQVSLDEHFSKMAAETDPHKSSEITKNLLPATLQLIDTYASFTRAYLLQNFNEEGTTEKPSKEKLQGFAAVLAIGSSRCKANTLGPTLVQNLPSSVQTVCESWNNINTNEFPNIGSWRNAFANDTIPSESYISAVQAAHLGTLCSQSLPLAASLKHTLLSLVRLTGDLIVWSDEMNPPQVIRTLLPLLLESSTESVAEISSNSLERILGPAESDEFLARVYEKLITGCYNILANHADPNSGLDESILEECLQYLEKQLESSQARKAMEEFFSDSGELVQIMMATANENLSAKFCNRVLKFFTKLFQLTEKSPNPSLLHLCGSLAQLACVEPVRLQAWLTRMTTSPPKDSDQLDVIQENRQLLQLLTTYIVRENSQVGEGVCAVLLGTLTPMATEMLANGDGTGFPELMVVMATLASAGQGAGHLQLHNAAVDWLSRCKKYLSQKNVVEKLNANVMHGKHVMILECTCHIMSYLADVTNALSQSNGQGPSHLSVDGEERAIEVDSDWVEELAVEEEDSQAEDSDEDSLCNKLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCLALVKRTPSSGMSSTMKESAFQSEPRISESLVRHASTSSPADKAKVTISDGKVADEEKPKKSSLCRTVEGCREELQNQANFSFAPLVLDMLNFLMDAIQTNFQQASAVGSSSRAQQALSELHTVEKAVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMCVLSSPHGRRQHLAVSHEKGKITVLQLSALLKQADSSKRKLTLTRLASAPVPFTVLSLTGNPCKEDYLAVCGLKDCHVLTFSSSGSVSDHLVLHPQLATGNFIIKAVWLPGSQTELAIVTADFVKIYDLCVDALSPTFYFLLPSSKIRDVTFLFNEEGKNIIVIMSSAGYIYTQLMEEASSAQQGPFYVTNVLEINHEDLKDSNSQVAGGGVSVYYSHVLQMLFFSYCQGKSFAATISRTTLEVLQLFPINIKSSNGGSKTSPALCQWSEVMNHPGLVCCVQQTTGVPLVVMVKPDTFLIQEIKTLPAKAKIQDMVAIRHTACNEQQRTTMILLCEDGSLRIYMANVENTSYWLQPSLQPSSVISIMKPVRKRKTATITTRTSSQVTFPIDFFEHNQQLTDVEFGGNDLLQVYNAQQIKHRLNSTGMYVANTKPGGFTIEISNNNSTMVMTGMRIQIGTQAIERAPSYIEIFGRTMQLNLSRSRWFDFPFTREEALQADKKLNLFIGASVDPAGVTMIDAVKIYGKTKEQFGWPDEPPEEFPSASVSNICPSNLNQSNGTGDSDSAAPTTTSGTVLERLVVSSLEALESCFAVGPIIEKERNKNAAQELATLLLSLPAPASVQQQSKSLLASLHTSRSAYHSHKDQALLSKAVQCLNTSSKEGKDLDPEVFQRLVITARSIAIMRPNNLVHFTESKLPQMETDCFFPRCACWSLGIVGILIGAPLETPSPEGMDEGKEPQKQLEGDCCSFITQLVNHFWKLHASKPKNAFLAPACLPGLTHIEATVNALVDIIHGYCTCELDCINTASKIYMQMLLCPDPAVSFSCKQALIRVLRPRNKRRHVTLPSSPRSNTPMGDKDDDDDDDADEKMQSSGIPNGGHIRQESQEQSEVDHGDFEMVSESMVLETAENVNNGNPSPLEALLAGAEGFPPMLDIPPDADDETMVELAIALSLQQDQQAPASDDEGSTAATDGSTLRTSPADHGGSVGSESGGSAVDSVAGEHSVSGRSSAYGDATAEGHPAGPGSVSSSTGAISTTTGHQEGDGSEGEGEGETEGDVHTSNRLHMVRLMLLERLLQTLPQLRNVGGVRAIPYMQVILMLTTDLDGEDEKDKGALDNLLSQLIAELGMDKKDVSKKNERSALNEVHLVVMRLLSVFMSRTKSGSKSSICESSSLISSATAAALLSSGAVDYCLHVLKSLLEYWKSQQNDEEPVATSQLLKPHTTSSPPDMSPFFLRQYVKGHAADVFEAYTQLLTEMVLRLPYQIKKITDTNSRIPPPVFDHSWFYFLSEYLMIQQTPFVRRQVRKLLLFICGSKEKYRQLRDLHTLDSHVRGIKKLLEEQGIFLRASVVTASSGSALQYDTLISLMEHLKACAEIAAQRTINWQKFCIKDDSVLYFLLQVSFLVDEGVSPVLLQLLSCALCGSKVLAALAASSGSSSASSSSAPVAASSGQATTQSKSSTKKSKKEEKEKEKDGETSGSQEDQLCTALVNQLNKFADKETLIQFLRCFLLESNSSSVRWQAHCLTLHIYRNSSKSQQELLLDLMWSIWPELPAYGRKAAQFVDLLGYFSLKTPQTEKKLKEYSQKAVEILRTQNHILTNHPNSNIYNTLSGLVEFDGYYLESDPCLVCNNPEVPFCYIKLSSIKVDTRYTTTQQVVKLIGSHTISKVTVKIGDLKRTKMVRTINLYYNNRTVQAIVELKNKPARWHKAKKVQLTPGQTEVKIDLPLPIVASNLMIEFADFYENYQASTETLQCPRCSASVPANPGVCGNCGENVYQCHKCRSINYDEKDPFLCNACGFCKYARFDFMLYAKPCCAVDPIENEEDRKKAVSNINTLLDKADRVYHQLMGHRPQLENLLCKVNEAAPEKPQDDSGTAGGISSTSASVNRYILQLAQEYCGDCKNSFDELSKIIQKVFASRKELLEYDLQQREAATKSSRTSVQPTFTASQYRALSVLGCGHTSSTKCYGCASAVTEHCITLLRALATNPALRHILVSQGLIRELFDYNLRRGAAAMREEVRQLMCLLTRDNPEATQQMNDLIIGKVSTALKGHWANPDLASSLQYEMLLLTDSISKEDSCWELRLRCALSLFLMAVNIKTPVVVENITLMCLRILQKLIKPPAPTSKKNKDVPVEALTTVKPYCNEIHAQAQLWLKRDPKASYDAWKKCLPIRGIDGNGKAPSKSELRHLYLTEKYVWRWKQFLSRRGKRTSPLDLKLGHNNWLRQVLFTPATQAARQAACTIVEALATIPSRKQQVLDLLTSYLDELSIAGECAAEYLALYQKLITSAHWKVYLAARGVLPYVGNLITKEIARLLALEEATLSTDLQQGYALKSLTGLLSSFVEVESIKRHFKSRLVGTVLNGYLCLRKLVVQRTKLIDETQDMLLEMLEDMTTGTESETKAFMAVCIETAKRYNLDDYRTPVFIFERLCSIIYPEENEVTEFFVTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLEDDSGMELLVNNKIISLDLPVAEVYKKVWCTTNEGEPMRIVYRMRGLLGDATEEFIESLDSTTDEEEDEEEVYKMAGVMAQCGGLECMLNRLAGIRDFKQGRHLLTVLLKLFSYCVKVKVNRQQLVKLEMNTLNVMLGTLNLALVAEQESKDSGGAAVAEQVLSIMEIILDESNAEPLSEDKGNLLLTGDKDQLVMLLDQINSTFVRSNPSVLQGLLRIIPYLSFGEVEKMQILVERFKPYCNFDKYDEDHSGDDKVFLDCFCKIAAGIKNNSNGHQLKDLILQKGITQNALDYMKKHIPSAKNLDADIWKKFLSRPALPFILRLLRGLAIQHPGTQVLIGTDSIPNLHKLEQVSSDEGIGTLAENLLEALREHPDVNKKIDAARRETRAEKKRMAMAMRQKALGTLGMTTNEKGQVVTKTALLKQMEELIEEPGLTCCICREGYKFQPTKVLGIYTFTKRVALEEMENKPRKQQGYSTVSHFNIVHYDCHLAAVRLARGREEWESAALQNANTKCNGLLPVWGPHVPESAFATCLARHNTYLQECTGQREPTYQLNIHDIKLLFLRFAMEQSFSADTGGGGRESNIHLIPYIIHTVLYVLNTTRATSREEKNLQGFLEQPKEKWVESAFEVDGPYYFTVLALHILPPEQWRATRVEILRRLLVTSQARAVAPGGATRLTDKAVKDYSAYRSSLLFWALVDLIYNMFKKVPTSNTEGGWSCSLAEYIRHNDMPIYEAADKALKTFQEEFMPVETFSEFLDVAGLLSEITDPESFLKDLLNSVP", "length": 5176, "header": "sp|Q5T4S7-4|UBR4_HUMAN Isoform 4 of E3 ubiquitin-protein ligase UBR4 OS=Homo sapiens OX=9606 GN=UBR4 PE=1 SV=1 CANONICAL=Q5T4S7-1" }, "locus": {} }, { "isoform_ac": "Q5T4S7-5", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7/entry#Q5T4S7-5", "sequence": { "sequence": "MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCSLIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPVSPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYINRFQDAVLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRTGSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSRTKEGVGSPKLGPGKGHQGFGVLSVILANHAIKLLTSLFQDLQVEALHKGWETDGPPAALSIMAQSTSIQRIQRLIDSVPLMNLLLTLLSTSYRKACVLQRQRKGSMSSDASASTDSNTYYEDDFSSTEEDSSQDDDSEPILGQWFEETISPSKEKAAPPPPPPPPPLESSPRVKSPSKQAPGEKGNILASRKDPELFLGLASNILNFITSSMLNSRNNFIRNYLSVSLSEHHMATLASIIKEVDKDGLKGSSDEEFAAALYHFNHSLVTSDLQSPNLQNTLLQQLGVAPFSEGPWPLYIHPQSLSVLSRLLLIWQHKASAQGDPDVPECLKVWDRFLSTMKQNALQGVVPSETEDLNVEHLQMLLLIFHNFTETGRRAILSLFVQIIQELSVNMDAQMRFVPLILARLLLIFDYLLHQYSKAPVYLFEQVQHNLLSPPFGWASGSQDSNSRRATTPLYHGFKEVEENWSKHFSSDAVPHPRFYCVLSPEASEDDLNRLDSVACDVLFSKLVKYDELYAALTALLAAGSQLDTVRRKENKNVTALEACALQYYFLILWRILGILPPSKTYINQLSMNSPEMSECDILHTLRWSSRLRISSYVNWIKDHLIKQGMKAEHASSLLELASTTKCSSVKYDVEIVEEYFARQISSFCSIDCTTILQLHEIPSLQSIYTLDAAISKVQVSLDEHFSKMAAETDPHKSSEITKNLLPATLQLIDTYASFTRAYLLQNFNEEGTTEKPSKEKLQGFAAVLAIGSSRCKANTLGPTLVQNLPSSVQTVCESWNNINTNEFPNIGSWRNAFANDTIPSESYISAVQAAHLGTLCSQSLPLAASLKHTLLSLVRLTGDLIVWSDEMNPPQVIRTLLPLLLESSTESVAEISSNSLERILGPAESDEFLARVYEKLITGCYNILANHADPNSGLDESILEECLQYLEKQLESSQARKAMEEFFSDSGELVQIMMATANENLSAKFCNRVLKFFTKLFQLTEKSPNPSLLHLCGSLAQLACVEPVRLQAWLTRMTTSPPKDSDQLDVIQENRQLLQLLTTYIVRENSQVGEGVCAVLLGTLTPMATEMLANGDGTGFPELMVVMATLASAGQGAGHLQLHNAAVDWLSRCKKYLSQKNVVEKLNANVMHGKHVMILECTCHIMSYLADVTNALSQSNGQGPSHLSVDGEERAIEVDSDWVEELAVEEEDSQAEDSDEDSLCNKLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCLALVKRTPSSGMSSTMKESAFQSEPRISESLVRHASTSSPADKAKVTISDGKVADEEKPKKSSLCRTVEGCREELQNQANFSFAPLVLDMLNFLMDAIQTNFQQASAVGSSSRAQQALSELHTVEKAVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMCVLSSPHGRRQHLAVSHEKGKITVLQLSALLKQADSSKRKLTLTRLASAPVPFTVLSLTGNPCKEDYLAVCGLKDCHVLTFSSSGSVSDHLVLHPQLATGNFIIKAVWLPGSQTELAIVTADFVKIYDLCVDALSPTFYFLLPSSKIRDVTFLFNEEGKNIIVIMSSAGYIYTQLMEEASSAQQGPFYVTNVLEINHEDLKQDSNSQVAGGGVSVYYSHVLQMLFFSYCQGKSFAATISRTTLEVLQLFPINIKSSNGGSKTSPALCQWSEVMNHPGLVCCVQQTTGVPLVVMVKPDTFLIQEIKTLPAKAKIQDMVAIRHTACNEQQRTTMILLCEDGSLRIYMANVENTSYWLQPSLQPSSVISIMKPVRKRKTATITTRTSSQVTFPIDFFEHNQQLTDVEFGGNDLLQVYNAQQIKHRLNSTGMYVANTKPGGFTIEISNNNSTMVMTGMRIQIGTQAIERAPSYIEIFGRTMQLNLSRSRWFDFPFTREEALQADKKLNLFSESPTPGADSVLIVTAKLGATGLWLSNILGSLHSADFSVLSSGNFELHLMY", "length": 2456, "header": "sp|Q5T4S7-5|UBR4_HUMAN Isoform 5 of E3 ubiquitin-protein ligase UBR4 OS=Homo sapiens OX=9606 GN=UBR4 PE=1 SV=1 CANONICAL=Q5T4S7-1" }, "locus": {} }, { "isoform_ac": "Q5T4S7-6", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7/entry#Q5T4S7-6", "sequence": { "sequence": "MVRTINLYYNNRTVQAIVELKNKPARWHKAKKVQLTPGQTEVKIDLPLPIVASNLMIEFADFYENYQASTETLQCPRCSASVPANPGVCGNCGENVYQCHKCRSINYDEKDPFLCNACGFCKYARFDFMLYAKPCCAVDPIENEEDRKKAVSNINTLLDKADRVYHQLMGHRPQLENLLCKVNEAAPEKPQVVPRCKGHLDKGLGLDQKTAS", "length": 212, "header": "sp|Q5T4S7-6|UBR4_HUMAN Isoform 6 of E3 ubiquitin-protein ligase UBR4 OS=Homo sapiens OX=9606 GN=UBR4 PE=1 SV=1 CANONICAL=Q5T4S7-1" }, "locus": { "chromosome": "1", "start_pos": 19117288, "end_pos": 19113882, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000375218.3", "url": "https://www.ensembl.org/id/ENST00000375218.3" }, { "database": "Ensembl Peptide", "id": "ENSP00000364366.3", "url": "https://www.ensembl.org/id/ENSP00000364366.3" } ] } }, { "isoform_ac": "Q5TBN9-1", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7/entry#Q5TBN9-1", "sequence": { "sequence": "MGPGKKGRCREEGPGRGRRAWIIRGSGSSRQGWVGSVESSKRSANVTRQRQIEQILPALAAGSCFHPAFILSCRFSSRTRATSREEKNLQGFLEQPKEKWVESAFEVDGPYYFTVLALHILPPEQWRATRVEILRRLLVTSQARAVAPGGATRLTDKAVKDYSAYRSSLLFWALVDLIYNMFKKVPTSNTEGGWSCSLAEYIRHNDMPIYEAADKALKTFQEEFMPVETFSEFLDVAGLLSEITDPESFLKDLLNSVP", "length": 258, "header": "tr|Q5TBN9-1|Q5TBN9_HUMAN Computationally mapped isoform of Ubiquitin protein ligase E3 component n-recognin 4 OS=Homo sapiens OX=9606 GN=UBR4 PE=1 SV=1 CANONICAL=Q5T4S7-1" }, "locus": { "chromosome": "1", "start_pos": 19081806, "end_pos": 19074835, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000375225.7", "url": "https://www.ensembl.org/id/ENST00000375225.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000364373.3", "url": "https://www.ensembl.org/id/ENSP00000364373.3" } ] } }, { "isoform_ac": "X6R960-1", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7/entry#X6R960-1", "sequence": { "sequence": "MLEDMTTGTESETKAFMAVCIETAKRYNLDDYRTPVFIFERLCSIIYPEENEVTEFFVTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLEDDSGMELLVNNKIISLDLPVAEVYKKVWCTTNEGEPMRIVYRMRGLLGDATEEFIESLDSTTDEEEDEEEVYKMAGVMAQCGGLECMLNRLAGIRDFKQGRHLLTVLLKLFSYCVKVKVNRQQLVKLEMNTLNVMLGTLNLALVAEQESKDSGGAAVAEQVLSIMEIILDESNAEPLSEDKGNLLLTGDKDQLVMLLDQINSTFVRSNPSVLQGLLRIIPYLSFGEVEKMQILVERFKPYCNFDKYDEDHSGDDKVFLDCFCKIAAGIKNNSNGHQLKDLILQKGITQNALDYMKKHIPSAKNLDADIWKKFLSRPALPFILRLLRGLAIQHPGTQVLIGTDSIPNLHKLEQVSSDEGIGTLAENLLEALREHPDVNKKIDAARRETRAEKKRMAMAMRQKALGTLGMTTNEKGQVVTKTALLKQMEELIEEPGLTCCICREGYKFQPTKVLGIYTFTKRVALEEMENKPRKQQGYSTVSHFNIVHYDCHLAAVRLARGREEWESAALQNANTKCNGLLPVWGPHVPESAFATCLARHNTYLQECTGQREPTYQLNIHDIKLLFLRFAMEQSFSADTGGGGRESNIHLIPYIIHTVLYVLNTTRATSREEKNLQGFLEQPKEKWVESAFEVDGPYYFTVLALHILPPEQWRATRVEILRRLLVTSQARAVAPGGATRLTDKAVKDYSAYRSSLLFWALVDLIYNMFKKVPTSNTEGGWSCSLAEYIRHNDMPIYEAADKALKTFQEEFMPVETFSEFLDVAGLLSEITDPESFLKDLLNSVP", "length": 890, "header": "tr|X6R960-1|UBR4_HUMAN Computationally mapped isoform of E3 ubiquitin-protein ligase UBR4 OS=Homo sapiens OX=9606 GN=UBR4 PE=1 SV=1 CANONICAL=Q5T4S7-1" }, "locus": { "chromosome": "1", "start_pos": 19104105, "end_pos": 19074835, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000375224.1", "url": "https://www.ensembl.org/id/ENST00000375224.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000364372.1", "url": "https://www.ensembl.org/id/ENSP00000364372.1" } ] } }, { "isoform_ac": "X6RE05-1", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7/entry#X6RE05-1", "sequence": { "sequence": "DFPFTREEALQADKKLNLFIGASVDPAGVTMIDAVKIYGKTKEQFGWPDEPPEEFPSASVSNICPSNLNQSNGTGDSDSAAPTTTSGTVLERLVVSSLEALESCFAVGPIIEKERNKNAAQELATLLLSLPAPASVQQQSKSLLASLHTSRSAYHSHKDQALLSKAVQCLNTSSKEGKDLDPEVFQRLVITARSIAIMRPNNLVHFTESKLPQMETDCFFPRCACWSLGIVGILIGAPLETPSPEGMDEGKEPQKQLEGDCCSFITQLVNHFWKLHASKPKNAFLAPACLPGLTHIEATVNALVDIIHGYCTCELDCINTASKIYMQMLLCPDPAVSFSCKQALIRVLRPRNKRRHVTLPSSPRSNTPMGDKDDDDDDDADEKMQSSGIPNGGHIRQESQEQSEVDHGDFEMVSESMVLETAENVNNGNPSPLEALLAGAEGFPPMLDIPPDADDETMVELAIALSLQQDQQAPASDDEGSTAATDGSTLRTSPADHGGSVGSESGGSAVDSVAGEHSVSGRSSAYGDATAEGHPAGPGSVSSSTGAISTTTGHQEGDGSEGEGEGETEGDVHTSNRLHMVRLMLLERLLQTLPQLRNVGGVRAIPYMQVILMLTTDLDGEDEKDKGALDNLLSQLIAELGMDKKDVSKKNERSALNEVHLVVMRLLSVFMSRTKSGSKSSICESSSLISSATAAALLSSGAVDYCLHVLKSLLEYWKSQQNDEEPVATSQLLKPHTTSSPPDMSPFFLRQYVKGHAADVFEAYTQLLTEMVLRLPYQIKKITDTNSRIPPPVFDHSWFYFLSEYLMIQQTPFVRRQVRKLLLFICGSKEKYRQLRDLHTLDSHVRGIKKLLEEQGIFLRASVVTASSGSALQYDTLISLMEHLKACAEIAAQRTINWQKFCIKDDSVLYFLLQVSFLVDEGVSPVLLQLLSCALCGSKVLAALAASSGSSSASSSSAPVAASSGQATTQSKSSTKKSKKEEKE", "length": 984, "header": "tr|X6RE05-1|UBR4_HUMAN Computationally mapped isoform of E3 ubiquitin-protein ligase UBR4 OS=Homo sapiens OX=9606 GN=UBR4 PE=1 SV=1 CANONICAL=Q5T4S7-1" }, "locus": { "chromosome": "1", "start_pos": 19151700, "end_pos": 19121202, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000425413.5", "url": "https://www.ensembl.org/id/ENST00000425413.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000395313.1", "url": "https://www.ensembl.org/id/ENSP00000395313.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_pos": 1343, "start_aa": "Ser", "end_pos": 1343, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser1343", "evidence": [ { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "Q5T4S7", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q5T4S7" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "38665916", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38665916" }, { "id": "37340703", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37340703" }, { "id": "40914422", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40914422" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "34229054", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34229054" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "Q5T4S7", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q5T4S7" } ], "filter_code": "00000000000000010000.0000000.00000001000000.1000000.0100000000.110100100001111011.10000.01001" }, { "glytoucan_ac": "G70994MS", "type": "O-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1343, "start_aa": "Ser", "end_pos": 1343, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser1343", "evidence": [ { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "GLY_000142", "database": "Data Submission", "url": "http://data.glygen.org/GLY_000142" } ], "filter_code": "00000000000000010000.0000000.00000000001000.1000000.0100000000.111111100011111111.01000.01001" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 18, "start_aa": "Thr", "end_pos": 18, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr18", "evidence": [ { "id": "GLY_001151", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001151" } ], "filter_code": "00000000000000001000.00000000001000.0.01001" }, { "glytoucan_ac": "G58356JX", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "TTMILLCEDGSLRIYMANVENTSYWLQPSLQPSSVISIMKPVR", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2248, "start_aa": "Asn", "end_pos": 2248, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn2248", "evidence": [ { "id": "10.1101/2023.09.13.557529", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "id": "GLY_000888", "database": "Data Submission", "url": "http://data.glygen.org/GLY_000888" } ], "filter_code": "00100000000000000000.0000000.00010000000000.0001000.1110000000.000000000001000000.00100.01000" }, { "glytoucan_ac": "G80920RR", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "TMQLNLSR", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2378, "start_aa": "Asn", "end_pos": 2378, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn2378", "evidence": [ { "id": "10.1101/2023.09.13.557529", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "id": "GLY_000888", "database": "Data Submission", "url": "http://data.glygen.org/GLY_000888" } ], "filter_code": "00100000000000000000.0000000.00010000000000.0100000.1100000000.110111110111111110.00010.01001" }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_pos": 3479, "start_aa": "Thr", "end_pos": 3479, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr3479", "evidence": [ { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "Q5T4S7", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q5T4S7" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "38665916", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38665916" }, { "id": "37340703", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37340703" }, { "id": "40914422", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40914422" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "34229054", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34229054" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "Q5T4S7", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q5T4S7" } ], "filter_code": "00000000000000001000.0000000.00000001000000.1000000.0100000000.110100100001111011.10000.01000" }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_pos": 3843, "start_aa": "Ser", "end_pos": 3843, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser3843", "evidence": [ { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "Q5T4S7", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q5T4S7" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "38665916", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38665916" }, { "id": "37340703", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37340703" }, { "id": "40914422", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40914422" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "34229054", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34229054" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "Q5T4S7", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q5T4S7" } ], "filter_code": "00000000000000010000.0000000.00000001000000.1000000.0100000000.110100100001111011.10000.01001" }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_pos": 625, "start_aa": "Ser", "end_pos": 625, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser625", "evidence": [ { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "Q5T4S7", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q5T4S7" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "38665916", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38665916" }, { "id": "37340703", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37340703" }, { "id": "40914422", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40914422" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "34229054", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34229054" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" } ], "filter_code": "00000000000000010000.0000000.00000001000000.1000000.0100000000.110100100001111011.10000.01011" }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_pos": 627, "start_aa": "Ser", "end_pos": 627, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser627", "evidence": [ { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "Q5T4S7", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q5T4S7" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "38665916", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38665916" }, { "id": "37340703", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37340703" }, { "id": "40914422", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40914422" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "34229054", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34229054" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" } ], "filter_code": "00000000000000010000.0000000.00000001000000.1000000.0100000000.110100100001111011.10000.01001" }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_pos": 870, "start_aa": "Ser", "end_pos": 870, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser870", "evidence": [ { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "Q5T4S7", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q5T4S7" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "38665916", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38665916" }, { "id": "37340703", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37340703" }, { "id": "40914422", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40914422" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "34229054", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34229054" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "Q5T4S7", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q5T4S7" } ], "filter_code": "00000000000000010000.0000000.00000001000000.1000000.0100000000.110100100001111011.10000.01000" }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_pos": 99, "start_aa": "Ser", "end_pos": 99, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser99", "evidence": [ { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "Q5T4S7", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q5T4S7" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "38665916", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38665916" }, { "id": "37340703", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37340703" }, { "id": "40914422", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40914422" }, { "id": "39302247", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/39302247" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "34229054", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34229054" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "Q5T4S7", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q5T4S7" } ], "filter_code": "00000000000000010000.0000000.00000001000000.1000000.0100000000.110100100001111011.10000.01000" } ], "phosphorylation": [ { "start_pos": 1077, "end_pos": 1077, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Thr1077" }, { "start_pos": 1078, "end_pos": 1078, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Thr1078" }, { "start_pos": 1123, "end_pos": 1123, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "IEDB", "id": "Q5T4S7", "url": "https://www.iedb.org/epitope/Q5T4S7" }, { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "32387766", "url": "https://glygen.org/publication/PubMed/32387766" } ], "site_lbl": "Thr1123" }, { "start_pos": 1402, "end_pos": 1402, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "site_lbl": "Ser1402" }, { "start_pos": 1572, "end_pos": 1572, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "IEDB", "id": "Q5T4S7", "url": "https://www.iedb.org/epitope/Q5T4S7" }, { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "32387766", "url": "https://glygen.org/publication/PubMed/32387766" } ], "site_lbl": "Ser1572" }, { "start_pos": 1647, "end_pos": 1647, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" } ], "site_lbl": "Ser1647" }, { "start_pos": 1652, "end_pos": 1652, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" } ], "site_lbl": "Ser1652" }, { "start_pos": 1747, "end_pos": 1747, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" } ], "site_lbl": "Ser1747" }, { "start_pos": 1754, "end_pos": 1754, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "site_lbl": "Ser1754" }, { "start_pos": 1760, "end_pos": 1760, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser1760" }, { "start_pos": 1761, "end_pos": 1761, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Thr1761" }, { "start_pos": 1762, "end_pos": 1762, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ], "site_lbl": "Ser1762" }, { "start_pos": 1763, "end_pos": 1763, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ], "site_lbl": "Ser1763" }, { "start_pos": 178, "end_pos": 178, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" } ], "site_lbl": "Ser178" }, { "start_pos": 181, "end_pos": 181, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "18767875", "url": "https://glygen.org/publication/PubMed/18767875" }, { "database": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" } ], "site_lbl": "Ser181" }, { "start_pos": 1878, "end_pos": 1878, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" } ], "site_lbl": "Ser1878" }, { "start_pos": 1904, "end_pos": 1904, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" } ], "site_lbl": "Ser1904" }, { "start_pos": 1927, "end_pos": 1927, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser1927" }, { "start_pos": 212, "end_pos": 212, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "site_lbl": "Ser212" }, { "start_pos": 2278, "end_pos": 2278, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" } ], "site_lbl": "Thr2278" }, { "start_pos": 2279, "end_pos": 2279, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" } ], "site_lbl": "Thr2279" }, { "start_pos": 2715, "end_pos": 2715, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Thr2715" }, { "start_pos": 2718, "end_pos": 2718, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "17924679", "url": "https://glygen.org/publication/PubMed/17924679" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" }, { "database": "PubMed", "id": "19415658", "url": "https://glygen.org/publication/PubMed/19415658" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser2718" }, { "start_pos": 2719, "end_pos": 2719, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" } ], "site_lbl": "Ser2719" }, { "start_pos": 2722, "end_pos": 2722, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ], "site_lbl": "Ser2722" }, { "start_pos": 2724, "end_pos": 2724, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ], "site_lbl": "Thr2724" }, { "start_pos": 2884, "end_pos": 2884, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278" }, { "database": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" } ], "site_lbl": "Thr2884" }, { "start_pos": 2944, "end_pos": 2944, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" } ], "site_lbl": "Thr2944" }, { "start_pos": 2952, "end_pos": 2952, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" } ], "site_lbl": "Ser2952" }, { "start_pos": 3175, "end_pos": 3175, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Thr3175" }, { "start_pos": 3177, "end_pos": 3177, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Thr3177" }, { "start_pos": 3179, "end_pos": 3179, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser3179" }, { "start_pos": 3432, "end_pos": 3432, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" } ], "site_lbl": "Thr3432" }, { "start_pos": 360, "end_pos": 360, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Thr360" }, { "start_pos": 363, "end_pos": 363, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Thr363" }, { "start_pos": 364, "end_pos": 364, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Ser364" }, { "start_pos": 365, "end_pos": 365, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Ser365" }, { "start_pos": 370, "end_pos": 370, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Tyr370" }, { "start_pos": 4270, "end_pos": 4270, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Tyr4270" }, { "start_pos": 473, "end_pos": 473, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "IEDB", "id": "Q5T4S7", "url": "https://www.iedb.org/epitope/Q5T4S7" }, { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "32387766", "url": "https://glygen.org/publication/PubMed/32387766" } ], "site_lbl": "Ser473" }, { "start_pos": 619, "end_pos": 619, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" }, { "database": "PubMed", "id": "19415658", "url": "https://glygen.org/publication/PubMed/19415658" }, { "database": "PubMed", "id": "19664995", "url": "https://glygen.org/publication/PubMed/19664995" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser619" }, { "start_pos": 620, "end_pos": 620, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" }, { "database": "PubMed", "id": "19415658", "url": "https://glygen.org/publication/PubMed/19415658" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" }, { "database": "PubMed", "id": "19664995", "url": "https://glygen.org/publication/PubMed/19664995" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser620" }, { "start_pos": 625, "end_pos": 625, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser625" }, { "start_pos": 905, "end_pos": 905, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" } ], "site_lbl": "Thr905" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan", "glycoprotein_predicted" ], "publication": [ { "title": "Deep quantitative glycoproteomics reveals gut microbiome induced remodeling of the brain glycoproteome", "journal": "bioRxiv", "date": "2023", "authors": "Potel C.M., Burtscher M.L., Garrido-Rodriguez M., Brauer-Nikonow A., Becher I., Typas A., Zimmermann M., Savitski M.", "evidence": [ { "database": "Data Submission", "id": "GLY_000888", "url": "http://data.glygen.org/GLY_000888" } ], "reference": [ { "type": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" } ] }, { "title": "Two new proteases in the MHC class I processing pathway.", "journal": "Nature immunology", "date": "2000", "authors": "Stoltze L, Schirle M, Schwarz G, Schroter C, Thompson MW, Hersh LB, Kalbacher H, Stevanovic S, Rammensee HG, Schild H", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "11062501", "url": "https://glygen.org/publication/PubMed/11062501" } ] }, { "title": "Initial sequencing and analysis of the human genome.", "journal": "Nature", "date": "2001", "authors": "Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W, Funke R, Gage D, Harris K, Heaford A, Howland J, Kann L, Lehoczky J, LeVine R, McEwan P, McKernan K, Meldrim J, Mesirov JP, Miranda C, Morris W, Naylor J, Raymond C, Rosetti M, Santos R, Sheridan A, Sougnez C, Stange-Thomann Y, Stojanovic N, Subramanian A, Wyman D, Rogers J, Sulston J, Ainscough R, Beck S, Bentley D, Burton J, Clee C, Carter N, Coulson A, Deadman R, Deloukas P, Dunham A, Dunham I, Durbin R, French L, Grafham D, Gregory S, Hubbard T, Humphray S, Hunt A, Jones M, Lloyd C, McMurray A, Matthews L, Mercer S, Milne S, Mullikin JC, Mungall A, Plumb R, Ross M, Shownkeen R, Sims S, Waterston RH, Wilson RK, Hillier LW, McPherson JD, Marra MA, Mardis ER, Fulton LA, Chinwalla AT, Pepin KH, Gish WR, Chissoe SL, Wendl MC, Delehaunty KD, Miner TL, Delehaunty A, Kramer JB, Cook LL, Fulton RS, Johnson DL, Minx PJ, Clifton SW, Hawkins T, Branscomb E, Predki P, Richardson P, Wenning S, Slezak T, Doggett N, Cheng JF, Olsen A, Lucas S, Elkin C, Uberbacher E, Frazier M, Gibbs RA, Muzny DM, Scherer SE, Bouck JB, Sodergren EJ, Worley KC, Rives CM, Gorrell JH, Metzker ML, Naylor SL, Kucherlapati RS, Nelson DL, Weinstock GM, Sakaki Y, Fujiyama A, Hattori M, Yada T, Toyoda A, Itoh T, Kawagoe C, Watanabe H, Totoki Y, Taylor T, Weissenbach J, Heilig R, Saurin W, Artiguenave F, Brottier P, Bruls T, Pelletier E, Robert C, Wincker P, Smith DR, Doucette-Stamm L, Rubenfield M, Weinstock K, Lee HM, Dubois J, Rosenthal A, Platzer M, Nyakatura G, Taudien S, Rump A, Yang H, Yu J, Wang J, Huang G, Gu J, Hood L, Rowen L, Madan A, Qin S, Davis RW, Federspiel NA, Abola AP, Proctor MJ, Myers RM, Schmutz J, Dickson M, Grimwood J, Cox DR, Olson MV, Kaul R, Raymond C, Shimizu N, Kawasaki K, Minoshima S, Evans GA, Athanasiou M, Schultz R, Roe BA, Chen F, Pan H, Ramser J, Lehrach H, Reinhardt R, McCombie WR, de la Bastide M, Dedhia N, Blocker H, Hornischer K, Nordsiek G, Agarwala R, Aravind L, Bailey JA, Bateman A, Batzoglou S, Birney E, Bork P, Brown DG, Burge CB, Cerutti L, Chen HC, Church D, Clamp M, Copley RR, Doerks T, Eddy SR, Eichler EE, Furey TS, Galagan J, Gilbert JG, Harmon C, Hayashizaki Y, Haussler D, Hermjakob H, Hokamp K, Jang W, Johnson LS, Jones TA, Kasif S, Kaspryzk A, Kennedy S, Kent WJ, Kitts P, Koonin EV, Korf I, Kulp D, Lancet D, Lowe TM, McLysaght A, Mikkelsen T, Moran JV, Mulder N, Pollara VJ, Ponting CP, Schuler G, Schultz J, Slater G, Smit AF, Stupka E, Szustakowki J, Thierry-Mieg D, Thierry-Mieg J, Wagner L, Wallis J, Wheeler R, Williams A, Wolf YI, Wolfe KH, Yang SP, Yeh RF, Collins F, Guyer MS, Peterson J, Felsenfeld A, Wetterstrand KA, Patrinos A, Morgan MJ, de Jong P, Catanese JJ, Osoegawa K, Shizuya H, Choi S, Chen YJ, Szustakowki J", "evidence": [ { "database": "UniProtKB", "id": "X6R960", "url": "https://www.uniprot.org/uniprotkb/X6R960" } ], "reference": [ { "type": "PubMed", "id": "11237011", "url": "https://glygen.org/publication/PubMed/11237011" } ] }, { "title": "26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide.", "journal": "The EMBO journal", "date": "2001", "authors": "Cascio P, Hilton C, Kisselev AF, Rock KL, Goldberg AL", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "11350924", "url": "https://glygen.org/publication/PubMed/11350924" } ] }, { "title": "U-box proteins as a new family of ubiquitin ligases.", "journal": "Biochemical and biophysical research communications", "date": "2003", "authors": "Hatakeyama S, Nakayama KI", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "12646216", "url": "https://glygen.org/publication/PubMed/12646216" } ] }, { "title": "Proteasome and peptidase function in MHC-class-I-mediated antigen presentation.", "journal": "Current opinion in immunology", "date": "2004", "authors": "Kloetzel PM, Ossendorp F", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "14734113", "url": "https://glygen.org/publication/PubMed/14734113" } ] }, { "title": "Generation of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPII.", "journal": "Nature immunology", "date": "2004", "authors": "Kloetzel PM", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "15224091", "url": "https://glygen.org/publication/PubMed/15224091" } ] }, { "title": "Post-proteasomal antigen processing for major histocompatibility complex class I presentation.", "journal": "Nature immunology", "date": "2004", "authors": "Rock KL, York IA, Goldberg AL", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "15224092", "url": "https://glygen.org/publication/PubMed/15224092" } ] }, { "title": "The proteasome and MHC class I antigen processing.", "journal": "Biochimica et biophysica acta", "date": "2004", "authors": "Kloetzel PM", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "15571818", "url": "https://glygen.org/publication/PubMed/15571818" } ] }, { "title": "Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2005", "authors": "Huh KW, DeMasi J, Ogawa H, Nakatani Y, Howley PM, Munger K", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "RefSeq", "id": "NP_065816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065816" } ], "reference": [ { "type": "PubMed", "id": "16061792", "url": "https://glygen.org/publication/PubMed/16061792" } ] }, { "title": "p600, a unique protein required for membrane morphogenesis and cell survival.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2005", "authors": "Nakatani Y, Konishi H, Vassilev A, Kurooka H, Ishiguro K, Sawada J, Ikura T, Korsmeyer SJ, Qin J, Herlitz AM", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "RefSeq", "id": "NP_065816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065816" } ], "reference": [ { "type": "PubMed", "id": "16214886", "url": "https://glygen.org/publication/PubMed/16214886" } ] }, { "title": "The response of autologous T cells to a human melanoma is dominated by mutated neoantigens.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2005", "authors": "Lennerz V, Fatho M, Gentilini C, Frye RA, Lifke A, Ferel D, Wolfel C, Huber C, Wolfel T", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "reference": [ { "type": "PubMed", "id": "16247014", "url": "https://glygen.org/publication/PubMed/16247014" } ] }, { "title": "Pleiotropic effects of ATP.Mg2+ binding in the catalytic cycle of ubiquitin-activating enzyme.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Tokgoz Z, Bohnsack RN, Haas AL", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "16595681", "url": "https://glygen.org/publication/PubMed/16595681" } ] }, { "title": "Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2006", "authors": "York IA, Bhutani N, Zendzian S, Goldberg AL, Rock KL", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "16849449", "url": "https://glygen.org/publication/PubMed/16849449" } ] }, { "title": "A novel family of membrane-bound E3 ubiquitin ligases.", "journal": "Journal of biochemistry", "date": "2006", "authors": "Ohmura-Hoshino M, Goto E, Matsuki Y, Aoki M, Mito M, Uematsu M, Hotta H, Ishido S", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "16954532", "url": "https://glygen.org/publication/PubMed/16954532" } ] }, { "title": "The consensus coding sequences of human breast and colorectal cancers.", "journal": "Science (New York, N.Y.)", "date": "2006", "authors": "Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "reference": [ { "type": "PubMed", "id": "16959974", "url": "https://glygen.org/publication/PubMed/16959974" } ] }, { "title": "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.", "journal": "Cell", "date": "2006", "authors": "Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7-1" } ], "reference": [ { "type": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" } ] }, { "title": "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.", "journal": "Journal of proteome research", "date": "2007", "authors": "Yu LR, Zhu Z, Chan KC, Issaq HJ, Dimitrov DS, Veenstra TD", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7-1" } ], "reference": [ { "type": "PubMed", "id": "17924679", "url": "https://glygen.org/publication/PubMed/17924679" } ] }, { "title": "Motif-specific sampling of phosphoproteomes.", "journal": "Journal of proteome research", "date": "2008", "authors": "Ruse CI, McClatchy DB, Lu B, Cociorva D, Motoyama A, Park SK, Yates JR 3rd", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7-1" } ], "reference": [ { "type": "PubMed", "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278" } ] }, { "title": "CLEC5A is critical for dengue-virus-induced lethal disease.", "journal": "Nature", "date": "2008", "authors": "Chen ST, Lin YL, Huang MT, Wu MF, Cheng SC, Lei HY, Lee CK, Chiou TW, Wong CH, Hsieh SL", "evidence": [ { "database": "Reactome", "id": "R-HSA-9920588", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9920588" } ], "reference": [ { "type": "PubMed", "id": "18496526", "url": "https://glygen.org/publication/PubMed/18496526" } ] }, { "title": "Structural insights into E1-catalyzed ubiquitin activation and transfer to conjugating enzymes.", "journal": "Cell", "date": "2008", "authors": "Lee I, Schindelin H", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "18662542", "url": "https://glygen.org/publication/PubMed/18662542" } ] }, { "title": "A quantitative atlas of mitotic phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "iPTMnet", "id": "Q5T4S7-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7-1" } ], "reference": [ { "type": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ] }, { "title": "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.", "journal": "Mol. Cell", "date": "2008", "authors": "Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "iPTMnet", "id": "Q5T4S7-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7-1" } ], "reference": [ { "type": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" } ] }, { "title": "Successive and selective release of phosphorylated peptides captured by hydroxy acid-modified metal oxide chromatography.", "journal": "Journal of proteome research", "date": "2008", "authors": "Kyono Y, Sugiyama N, Imami K, Tomita M, Ishihama Y", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7-1" } ], "reference": [ { "type": "PubMed", "id": "18767875", "url": "https://glygen.org/publication/PubMed/18767875" } ] }, { "title": "Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.", "journal": "The international journal of biochemistry & cell biology", "date": "2009", "authors": "Ebstein F, Lange N, Urban S, Seifert U, Kruger E, Kloetzel PM", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "19028597", "url": "https://glygen.org/publication/PubMed/19028597" } ] }, { "title": "Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways.", "journal": "Nature reviews. Molecular cell biology", "date": "2009", "authors": "Schulman BA, Harper JW", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "19352404", "url": "https://glygen.org/publication/PubMed/19352404" } ] }, { "title": "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.", "journal": "Analytical chemistry", "date": "2009", "authors": "Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7-1" } ], "reference": [ { "type": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" } ] }, { "title": "Phosphoproteomic analysis of distinct tumor cell lines in response to nocodazole treatment.", "journal": "Proteomics", "date": "2009", "authors": "Nagano K, Shinkawa T, Mutoh H, Kondoh O, Morimoto S, Inomata N, Ashihara M, Ishii N, Aoki Y, Haramura M", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7-1" } ], "reference": [ { "type": "PubMed", "id": "19415658", "url": "https://glygen.org/publication/PubMed/19415658" } ] }, { "title": "What was the set of ubiquitin and ubiquitin-like conjugating enzymes in the eukaryote common ancestor?", "journal": "Journal of molecular evolution", "date": "2009", "authors": "Michelle C, Vourc'h P, Mignon L, Andres CR", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "19452197", "url": "https://glygen.org/publication/PubMed/19452197" } ] }, { "title": "RING domain E3 ubiquitin ligases.", "journal": "Annual review of biochemistry", "date": "2009", "authors": "Deshaies RJ, Joazeiro CA", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "19489725", "url": "https://glygen.org/publication/PubMed/19489725" } ] }, { "title": "Lysine acetylation targets protein complexes and co-regulates major cellular functions.", "journal": "Science (New York, N.Y.)", "date": "2009", "authors": "Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "reference": [ { "type": "PubMed", "id": "19608861", "url": "https://glygen.org/publication/PubMed/19608861" } ] }, { "title": "Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Pan C, Olsen JV, Daub H, Mann M", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7-1" } ], "reference": [ { "type": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ] }, { "title": "Phosphoproteomic analysis of human embryonic stem cells.", "journal": "Cell stem cell", "date": "2009", "authors": "Brill LM, Xiong W, Lee KB, Ficarro SB, Crain A, Xu Y, Terskikh A, Snyder EY, Ding S", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7-1" } ], "reference": [ { "type": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" } ] }, { "title": "Phosphorylation dynamics during early differentiation of human embryonic stem cells.", "journal": "Cell stem cell", "date": "2009", "authors": "Van Hoof D, Munoz J, Braam SR, Pinkse MW, Linding R, Heck AJ, Mummery CL, Krijgsveld J", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7-1" } ], "reference": [ { "type": "PubMed", "id": "19664995", "url": "https://glygen.org/publication/PubMed/19664995" } ] }, { "title": "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.", "journal": "Science signaling", "date": "2009", "authors": "Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" } ], "reference": [ { "type": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" } ] }, { "title": "Dengue virus NS5 inhibits interferon-alpha signaling by blocking signal transducer and activator of transcription 2 phosphorylation.", "journal": "The Journal of infectious diseases", "date": "2009-10-15", "authors": "Mazzon Michela, Jones Meleri, Davidson Andrew, Chain Benjamin, Jacobs Michael", "evidence": [ { "database": "Reactome", "id": "R-HSA-9920588", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9920588" } ], "reference": [ { "type": "PubMed", "id": "19754307", "url": "https://glygen.org/publication/PubMed/19754307" } ] }, { "title": "Building ubiquitin chains: E2 enzymes at work.", "journal": "Nature reviews. Molecular cell biology", "date": "2009", "authors": "Ye Y, Rape M", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "19851334", "url": "https://glygen.org/publication/PubMed/19851334" } ] }, { "title": "Mechanisms of ubiquitin transfer by the anaphase-promoting complex.", "journal": "Journal of biology", "date": "2009", "authors": "Matyskiela ME, Rodrigo-Brenni MC, Morgan DO", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "19874575", "url": "https://glygen.org/publication/PubMed/19874575" } ] }, { "title": "The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteins.", "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology", "date": "2010", "authors": "van Wijk SJ, Timmers HT", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "19940261", "url": "https://glygen.org/publication/PubMed/19940261" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "iPTMnet", "id": "Q5T4S7-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7-1" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "Phosphoproteome analysis of human liver tissue by long-gradient nanoflow LC coupled with multiple stage MS analysis.", "journal": "Electrophoresis", "date": "2010", "authors": "Han G, Ye M, Liu H, Song C, Sun D, Wu Y, Jiang X, Chen R, Wang C, Wang L, Zou H", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7-1" } ], "reference": [ { "type": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" } ] }, { "title": "The nature of peptides presented by an HLA class I low expression allele.", "journal": "Haematologica", "date": "2010-08", "authors": "Hinrichs Jan, F\u00f6ll Daniel, Bade-D\u00f6ding Christina, Huyton Trevor, Blasczyk Rainer, Eiz-Vesper Britta", "evidence": [ { "database": "IEDB", "id": "548318", "url": "https://www.iedb.org/epitope/548318" } ], "reference": [ { "type": "PubMed", "id": "20220067", "url": "https://glygen.org/publication/PubMed/20220067" } ] }, { "title": "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.", "journal": "Science signaling", "date": "2011", "authors": "Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" } ], "reference": [ { "type": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" } ] }, { "title": "Structural flexibility of the macrophage dengue virus receptor CLEC5A: implications for ligand binding and signaling.", "journal": "The Journal of biological chemistry", "date": "2011-07-08", "authors": "Watson Aleksandra A, Lebedev Andrey A, Hall Benjamin A, Fenton-May Angharad E, Vagin Alexei A, Dejnirattisai Wanwisa, Felce James, Mongkolsapaya Juthathip, Palma Angelina S, Liu Yan, Feizi Ten, Screaton Gavin R, Murshudov Garib N, O'Callaghan Christopher A", "evidence": [ { "database": "Reactome", "id": "R-HSA-9920588", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9920588" } ], "reference": [ { "type": "PubMed", "id": "21566123", "url": "https://glygen.org/publication/PubMed/21566123" } ] }, { "title": "Secreted HLA recapitulates the immunopeptidome and allows in-depth coverage of HLA A*02:01 ligands.", "journal": "Molecular immunology", "date": "2012-06", "authors": "Scull Katherine E, Dudek Nadine L, Corbett Alexandra J, Ramarathinam Sri H, Gorasia Dhana G, Williamson Nicholas A, Purcell Anthony W", "evidence": [ { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "489168", "url": "https://www.iedb.org/epitope/489168" } ], "reference": [ { "type": "PubMed", "id": "22424782", "url": "https://glygen.org/publication/PubMed/22424782" } ] }, { "title": "Two preferentially expressed proteins protect vascular endothelial cells from an attack by peptide-specific CTL.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2012-06-01", "authors": "Thommen Daniela S, Schuster Heiko, Keller Mario, Kapoor Sarika, Weinzierl Andreas O, Chennakesava Cuddapah S, Wang Xueya, Rohrer Lucia, von Eckardstein Arnold, Stevanovic Stefan, Biedermann Barbara C", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" } ], "reference": [ { "type": "PubMed", "id": "22544926", "url": "https://glygen.org/publication/PubMed/22544926" } ] }, { "title": "Molecular cloning and primary structure of rat testes metalloendopeptidase EC 3.4.24.15.", "journal": "Biochemistry", "date": "1990", "authors": "Pierotti A, Dong KW, Glucksman MJ, Orlowski M, Roberts JL", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "2261476", "url": "https://glygen.org/publication/PubMed/2261476" } ] }, { "title": "Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2012-06-19", "authors": "Ostrov David A, Grant Barry J, Pompeu Yuri A, Sidney John, Harndahl Mikkel, Southwood Scott, Oseroff Carla, Lu Shun, Jakoncic Jean, de Oliveira Cesar Augusto F, Yang Lun, Mei Hu, Shi Leming, Shabanowitz Jeffrey, English A Michelle, Wriston Amanda, Lucas Andrew, Phillips Elizabeth, Mallal Simon, Grey Howard M, Sette Alessandro, Hunt Donald F, Buus Soren, Peters Bjoern", "evidence": [ { "database": "IEDB", "id": "175897", "url": "https://www.iedb.org/epitope/175897" } ], "reference": [ { "type": "PubMed", "id": "22645359", "url": "https://glygen.org/publication/PubMed/22645359" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "Proteome wide purification and identification of O-GlcNAc-modified proteins using click chemistry and mass spectrometry.", "journal": "Journal of proteome research", "date": "2013", "authors": "Hahne H, Sobotzki N, Nyberg T, Helm D, Borodkin VS, van Aalten DM, Agnew B, Kuster B", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q5T4S7", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q5T4S7" } ], "reference": [ { "type": "PubMed", "id": "23301498", "url": "https://glygen.org/publication/PubMed/23301498" } ] }, { "title": "The human leukocyte antigen-presented ligandome of B lymphocytes.", "journal": "Molecular & cellular proteomics : MCP", "date": "2013-07", "authors": "Hassan Chopie, Kester Michel G D, de Ru Arnoud H, Hombrink Pleun, Drijfhout Jan Wouter, Nijveen Harm, Leunissen Jack A M, Heemskerk Mirjam H M, Falkenburg J H Frederik, van Veelen Peter A", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "436141", "url": "https://www.iedb.org/epitope/436141" }, { "database": "IEDB", "id": "437318", "url": "https://www.iedb.org/epitope/437318" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "447449", "url": "https://www.iedb.org/epitope/447449" }, { "database": "IEDB", "id": "453074", "url": "https://www.iedb.org/epitope/453074" }, { "database": "IEDB", "id": "457112", "url": "https://www.iedb.org/epitope/457112" }, { "database": "IEDB", "id": "459480", "url": "https://www.iedb.org/epitope/459480" }, { "database": "IEDB", "id": "459761", "url": "https://www.iedb.org/epitope/459761" } ], "reference": [ { "type": "PubMed", "id": "23481700", "url": "https://glygen.org/publication/PubMed/23481700" } ] }, { "title": "Proteome profiling of human neutrophil granule subsets, secretory vesicles, and cell membrane: correlation with transcriptome profiling of neutrophil precursors.", "journal": "Journal of leukocyte biology", "date": "2013", "authors": "Rorvig S, Ostergaard O, Heegaard NH, Borregaard N", "evidence": [ { "database": "Reactome", "id": "R-HSA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6798695" } ], "reference": [ { "type": "PubMed", "id": "23650620", "url": "https://glygen.org/publication/PubMed/23650620" } ] }, { "title": "Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth.", "journal": "Molecular cell", "date": "2013", "authors": "Lin R, Tao R, Gao X, Li T, Zhou X, Guan KL, Xiong Y, Lei QY", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "reference": [ { "type": "PubMed", "id": "23932781", "url": "https://glygen.org/publication/PubMed/23932781" } ] }, { "title": "A novel locus for episodic ataxia:UBR4 the likely candidate.", "journal": "European journal of human genetics : EJHG", "date": "2014", "authors": "Conroy J, McGettigan P, Murphy R, Webb D, Murphy SM, McCoy B, Albertyn C, McCreary D, McDonagh C, Walsh O, Lynch S, Ennis S", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "reference": [ { "type": "PubMed", "id": "23982692", "url": "https://glygen.org/publication/PubMed/23982692" } ] }, { "title": "Dengue virus subverts the interferon induction pathway via NS2B/3 protease-IkappaB kinase epsilon interaction.", "journal": "Clinical and vaccine immunology : CVI", "date": "2014", "authors": "Anglero-Rodriguez YI, Pantoja P, Sariol CA", "evidence": [ { "database": "Reactome", "id": "R-HSA-9920588", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9920588" } ], "reference": [ { "type": "PubMed", "id": "24173023", "url": "https://glygen.org/publication/PubMed/24173023" } ] }, { "title": "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.", "journal": "Journal of proteomics", "date": "2014", "authors": "Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" } ], "reference": [ { "type": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" } ] }, { "title": "Increased diversity of the HLA-B40 ligandome by the presentation of peptides phosphorylated at their main anchor residue.", "journal": "Molecular & cellular proteomics : MCP", "date": "2014-02", "authors": "Marcilla Miguel, Alp\u00edzar Ad\u00e1n, Lombard\u00eda Manuel, Ramos-Fernandez Antonio, Ramos Manuel, Albar Juan Pablo", "evidence": [ { "database": "IEDB", "id": "224160", "url": "https://www.iedb.org/epitope/224160" } ], "reference": [ { "type": "PubMed", "id": "24366607", "url": "https://glygen.org/publication/PubMed/24366607" } ] }, { "title": "Impact of genomic polymorphisms on the repertoire of human MHC class I-associated peptides.", "journal": "Nature communications", "date": "2014-04-09", "authors": "Granados Diana Paola, Sriranganadane Dev, Daouda Tariq, Zieger Antoine, Laumont C\u00e9line M, Caron-Lizotte Olivier, Boucher Genevi\u00e8ve, Hardy Marie-Pierre, Gendron Patrick, C\u00f4t\u00e9 Caroline, Lemieux S\u00e9bastien, Thibault Pierre, Perreault Claude", "evidence": [ { "database": "IEDB", "id": "203328", "url": "https://www.iedb.org/epitope/203328" }, { "database": "IEDB", "id": "219588", "url": "https://www.iedb.org/epitope/219588" } ], "reference": [ { "type": "PubMed", "id": "24714562", "url": "https://glygen.org/publication/PubMed/24714562" } ] }, { "title": "The nature and extent of contributions by defective ribosome products to the HLA peptidome.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2014-04-22", "authors": "Bourdetsky Dmitry, Schmelzer Christian E H, Admon Arie", "evidence": [ { "database": "IEDB", "id": "437318", "url": "https://www.iedb.org/epitope/437318" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "446446", "url": "https://www.iedb.org/epitope/446446" }, { "database": "IEDB", "id": "447449", "url": "https://www.iedb.org/epitope/447449" }, { "database": "IEDB", "id": "459480", "url": "https://www.iedb.org/epitope/459480" }, { "database": "IEDB", "id": "479903", "url": "https://www.iedb.org/epitope/479903" }, { "database": "IEDB", "id": "486318", "url": "https://www.iedb.org/epitope/486318" }, { "database": "IEDB", "id": "504446", "url": "https://www.iedb.org/epitope/504446" }, { "database": "IEDB", "id": "505005", "url": "https://www.iedb.org/epitope/505005" }, { "database": "IEDB", "id": "505055", "url": "https://www.iedb.org/epitope/505055" }, { "database": "IEDB", "id": "506107", "url": "https://www.iedb.org/epitope/506107" } ], "reference": [ { "type": "PubMed", "id": "24715725", "url": "https://glygen.org/publication/PubMed/24715725" } ] }, { "title": "Revisiting the arthritogenic peptide theory: quantitative not qualitative changes in the peptide repertoire of HLA-B27 allotypes.", "journal": "Arthritis & rheumatology (Hoboken, N.J.)", "date": "2015-03", "authors": "Schittenhelm Ralf B, Sian Terry C C Lim Kam, Wilmann Pascal G, Dudek Nadine L, Purcell Anthony W", "evidence": [ { "database": "IEDB", "id": "241528", "url": "https://www.iedb.org/epitope/241528" }, { "database": "IEDB", "id": "445228", "url": "https://www.iedb.org/epitope/445228" }, { "database": "IEDB", "id": "490366", "url": "https://www.iedb.org/epitope/490366" }, { "database": "IEDB", "id": "490433", "url": "https://www.iedb.org/epitope/490433" }, { "database": "IEDB", "id": "491519", "url": "https://www.iedb.org/epitope/491519" }, { "database": "IEDB", "id": "493110", "url": "https://www.iedb.org/epitope/493110" }, { "database": "IEDB", "id": "493356", "url": "https://www.iedb.org/epitope/493356" }, { "database": "IEDB", "id": "495864", "url": "https://www.iedb.org/epitope/495864" } ], "reference": [ { "type": "PubMed", "id": "25418920", "url": "https://glygen.org/publication/PubMed/25418920" } ] }, { "title": "Dominant role of the ERAP1 polymorphism R528K in shaping the HLA-B27 Peptidome through differential processing determined by multiple peptide residues.", "journal": "Arthritis & rheumatology (Hoboken, N.J.)", "date": "2015-03", "authors": "Sanz-Bravo Alejandro, Campos Jos\u00e9, Mazariegos Marina S, L\u00f3pez de Castro Jos\u00e9 A", "evidence": [ { "database": "IEDB", "id": "241528", "url": "https://www.iedb.org/epitope/241528" } ], "reference": [ { "type": "PubMed", "id": "25469497", "url": "https://glygen.org/publication/PubMed/25469497" } ] }, { "title": "Mass spectrometry of human leukocyte antigen class I peptidomes reveals strong effects of protein abundance and turnover on antigen presentation.", "journal": "Molecular & cellular proteomics : MCP", "date": "2015-03", "authors": "Bassani-Sternberg Michal, Pletscher-Frankild Sune, Jensen Lars Juhl, Mann Matthias", "evidence": [ { "database": "IEDB", "id": "431157", "url": "https://www.iedb.org/epitope/431157" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "446446", "url": "https://www.iedb.org/epitope/446446" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "469366", "url": "https://www.iedb.org/epitope/469366" }, { "database": "IEDB", "id": "479903", "url": "https://www.iedb.org/epitope/479903" }, { "database": "IEDB", "id": "481713", "url": "https://www.iedb.org/epitope/481713" }, { "database": "IEDB", "id": "484733", "url": "https://www.iedb.org/epitope/484733" }, { "database": "IEDB", "id": "485565", "url": "https://www.iedb.org/epitope/485565" }, { "database": "IEDB", "id": "486318", "url": "https://www.iedb.org/epitope/486318" }, { "database": "IEDB", "id": "486924", "url": "https://www.iedb.org/epitope/486924" } ], "reference": [ { "type": "PubMed", "id": "25576301", "url": "https://glygen.org/publication/PubMed/25576301" } ] }, { "title": "KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation.", "journal": "Molecular & cellular proteomics : MCP", "date": "2015", "authors": "Hong JH, Kaustov L, Coyaud E, Srikumar T, Wan J, Arrowsmith C, Raught B", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "reference": [ { "type": "PubMed", "id": "25582440", "url": "https://glygen.org/publication/PubMed/25582440" } ] }, { "title": "Exploration of peptides bound to MHC class I molecules in melanoma.", "journal": "Pigment cell & melanoma research", "date": "2015-05", "authors": "Pritchard Antonia L, Hastie Marcus L, Neller Michelle, Gorman Jeffrey J, Schmidt Chris W, Hayward Nicholas K", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "444312", "url": "https://www.iedb.org/epitope/444312" }, { "database": "IEDB", "id": "446446", "url": "https://www.iedb.org/epitope/446446" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "471688", "url": "https://www.iedb.org/epitope/471688" }, { "database": "IEDB", "id": "541918", "url": "https://www.iedb.org/epitope/541918" }, { "database": "IEDB", "id": "542799", "url": "https://www.iedb.org/epitope/542799" }, { "database": "IEDB", "id": "543334", "url": "https://www.iedb.org/epitope/543334" }, { "database": "IEDB", "id": "543716", "url": "https://www.iedb.org/epitope/543716" }, { "database": "IEDB", "id": "545530", "url": "https://www.iedb.org/epitope/545530" }, { "database": "IEDB", "id": "545696", "url": "https://www.iedb.org/epitope/545696" } ], "reference": [ { "type": "PubMed", "id": "25645385", "url": "https://glygen.org/publication/PubMed/25645385" } ] }, { "title": "A comprehensive analysis of peptides presented by HLA-A1.", "journal": "Tissue antigens", "date": "2015-06", "authors": "Giam K, Ayala-Perez R, Illing P T, Schittenhelm R B, Croft N P, Purcell A W, Dudek N L", "evidence": [ { "database": "IEDB", "id": "431157", "url": "https://www.iedb.org/epitope/431157" }, { "database": "IEDB", "id": "432489", "url": "https://www.iedb.org/epitope/432489" } ], "reference": [ { "type": "PubMed", "id": "25880248", "url": "https://glygen.org/publication/PubMed/25880248" } ] }, { "title": "Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Polymorphism Relevant to Inflammatory Disease Shapes the Peptidome of the Birdshot Chorioretinopathy-Associated HLA-A*29:02 Antigen.", "journal": "Molecular & cellular proteomics : MCP", "date": "2015-07", "authors": "Alvarez-Navarro Carlos, Mart\u00edn-Esteban Adrian, Barnea Eilon, Admon Arie, L\u00f3pez de Castro Jos\u00e9 A", "evidence": [ { "database": "IEDB", "id": "425406", "url": "https://www.iedb.org/epitope/425406" }, { "database": "IEDB", "id": "427293", "url": "https://www.iedb.org/epitope/427293" } ], "reference": [ { "type": "PubMed", "id": "25892735", "url": "https://glygen.org/publication/PubMed/25892735" } ] }, { "title": "An open-source computational and data resource to analyze digital maps of immunopeptidomes.", "journal": "eLife", "date": "2015-07-08", "authors": "Caron Etienne, Espona Lucia, Kowalewski Daniel J, Schuster Heiko, Ternette Nicola, Alp\u00edzar Ad\u00e1n, Schittenhelm Ralf B, Ramarathinam Sri H, Lindestam Arlehamn Cecilia S, Chiek Koh Ching, Gillet Ludovic C, Rabsteyn Armin, Navarro Pedro, Kim Sangtae, Lam Henry, Sturm Theo, Marcilla Miguel, Sette Alessandro, Campbell David S, Deutsch Eric W, Moritz Robert L, Purcell Anthony W, Rammensee Hans-Georg, Stevanovic Stefan, Aebersold Ruedi", "evidence": [ { "database": "IEDB", "id": "175897", "url": "https://www.iedb.org/epitope/175897" }, { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "203328", "url": "https://www.iedb.org/epitope/203328" }, { "database": "IEDB", "id": "224160", "url": "https://www.iedb.org/epitope/224160" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "443759", "url": "https://www.iedb.org/epitope/443759" }, { "database": "IEDB", "id": "444312", "url": "https://www.iedb.org/epitope/444312" }, { "database": "IEDB", "id": "445228", "url": "https://www.iedb.org/epitope/445228" }, { "database": "IEDB", "id": "445527", "url": "https://www.iedb.org/epitope/445527" }, { "database": "IEDB", "id": "446446", "url": "https://www.iedb.org/epitope/446446" }, { "database": "IEDB", "id": "447449", "url": "https://www.iedb.org/epitope/447449" }, { "database": "IEDB", "id": "448851", "url": "https://www.iedb.org/epitope/448851" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" } ], "reference": [ { "type": "PubMed", "id": "26154972", "url": "https://glygen.org/publication/PubMed/26154972" } ] }, { "title": "Comprehensive Analysis of the Naturally Processed Peptide Repertoire: Differences between HLA-A and B in the Immunopeptidome.", "journal": "PloS one", "date": "2015", "authors": "Schellens Ingrid M M, Hoof Ilka, Meiring Hugo D, Spijkers Sanne N M, Poelen Martien C M, van Gaans-van den Brink Jacqueline A M, van der Poel Kees, Costa Ana I, van Els Cecile A C M, van Baarle Debbie, Kesmir Can", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "436141", "url": "https://www.iedb.org/epitope/436141" }, { "database": "IEDB", "id": "437318", "url": "https://www.iedb.org/epitope/437318" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "441519", "url": "https://www.iedb.org/epitope/441519" } ], "reference": [ { "type": "PubMed", "id": "26375851", "url": "https://glygen.org/publication/PubMed/26375851" } ] }, { "title": "Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames.", "journal": "Nature communications", "date": "2016-01-05", "authors": "Laumont C\u00e9line M, Daouda Tariq, Laverdure Jean-Philippe, Bonneil \u00c9ric, Caron-Lizotte Olivier, Hardy Marie-Pierre, Granados Diana P, Durette Chantal, Lemieux S\u00e9bastien, Thibault Pierre, Perreault Claude", "evidence": [ { "database": "IEDB", "id": "203328", "url": "https://www.iedb.org/epitope/203328" }, { "database": "IEDB", "id": "219588", "url": "https://www.iedb.org/epitope/219588" } ], "reference": [ { "type": "PubMed", "id": "26728094", "url": "https://glygen.org/publication/PubMed/26728094" } ] }, { "title": "Comparative Analysis of the Endogenous Peptidomes Displayed by HLA-B*27 and Mamu-B*08: Two MHC Class I Alleles Associated with Elite Control of HIV/SIV Infection.", "journal": "Journal of proteome research", "date": "2016-03-04", "authors": "Marcilla Miguel, Alvarez I\u00f1aki, Ramos-Fern\u00e1ndez Antonio, Lombard\u00eda Manuel, Paradela Alberto, Albar Juan Pablo", "evidence": [ { "database": "IEDB", "id": "241528", "url": "https://www.iedb.org/epitope/241528" }, { "database": "IEDB", "id": "491519", "url": "https://www.iedb.org/epitope/491519" }, { "database": "IEDB", "id": "522560", "url": "https://www.iedb.org/epitope/522560" } ], "reference": [ { "type": "PubMed", "id": "26811146", "url": "https://glygen.org/publication/PubMed/26811146" } ] }, { "title": "High-sensitivity HLA class I peptidome analysis enables a precise definition of peptide motifs and the identification of peptides from cell lines and patients' sera.", "journal": "Proteomics", "date": "2016-05", "authors": "Ritz Danilo, Gloger Andreas, Weide Benjamin, Garbe Claus, Neri Dario, Fugmann Tim", "evidence": [ { "database": "IEDB", "id": "175897", "url": "https://www.iedb.org/epitope/175897" }, { "database": "IEDB", "id": "224160", "url": "https://www.iedb.org/epitope/224160" }, { "database": "IEDB", "id": "241528", "url": "https://www.iedb.org/epitope/241528" }, { "database": "IEDB", "id": "436141", "url": "https://www.iedb.org/epitope/436141" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "441072", "url": "https://www.iedb.org/epitope/441072" }, { "database": "IEDB", "id": "481713", "url": "https://www.iedb.org/epitope/481713" }, { "database": "IEDB", "id": "504446", "url": "https://www.iedb.org/epitope/504446" }, { "database": "IEDB", "id": "505005", "url": "https://www.iedb.org/epitope/505005" }, { "database": "IEDB", "id": "505055", "url": "https://www.iedb.org/epitope/505055" }, { "database": "IEDB", "id": "614338", "url": "https://www.iedb.org/epitope/614338" }, { "database": "IEDB", "id": "617605", "url": "https://www.iedb.org/epitope/617605" }, { "database": "IEDB", "id": "618628", "url": "https://www.iedb.org/epitope/618628" }, { "database": "IEDB", "id": "620554", "url": "https://www.iedb.org/epitope/620554" }, { "database": "IEDB", "id": "622086", "url": "https://www.iedb.org/epitope/622086" }, { "database": "IEDB", "id": "622929", "url": "https://www.iedb.org/epitope/622929" }, { "database": "IEDB", "id": "623545", "url": "https://www.iedb.org/epitope/623545" }, { "database": "IEDB", "id": "623918", "url": "https://www.iedb.org/epitope/623918" }, { "database": "IEDB", "id": "627102", "url": "https://www.iedb.org/epitope/627102" } ], "reference": [ { "type": "PubMed", "id": "26992070", "url": "https://glygen.org/publication/PubMed/26992070" } ] }, { "title": "Structural and Nonstructural Viral Proteins Are Targets of T-Helper Immune Response against Human Respiratory Syncytial Virus.", "journal": "Molecular & cellular proteomics : MCP", "date": "2016-06", "authors": "Lorente Elena, Barriga Alejandro, Barnea Eilon, Mir Carmen, Gebe John A, Admon Arie, L\u00f3pez Daniel", "evidence": [ { "database": "IEDB", "id": "543350", "url": "https://www.iedb.org/epitope/543350" } ], "reference": [ { "type": "PubMed", "id": "27090790", "url": "https://glygen.org/publication/PubMed/27090790" } ] }, { "title": "Personalized peptide vaccine-induced immune response associated with long-term survival of a metastatic cholangiocarcinoma patient.", "journal": "Journal of hepatology", "date": "2016-10", "authors": "L\u00f6ffler Markus W, Chandran P Anoop, Laske Karoline, Schroeder Christopher, Bonzheim Irina, Walzer Mathias, Hilke Franz J, Trautwein Nico, Kowalewski Daniel J, Schuster Heiko, G\u00fcnder Marc, Carcamo Ya\u00f1ez Viviana A, Mohr Christopher, Sturm Marc, Nguyen Huu-Phuc, Riess Olaf, Bauer Peter, Nahnsen Sven, Nadalin Silvio, Zieker Derek, Glatzle J\u00f6rg, Thiel Karolin, Schneiderhan-Marra Nicole, Clasen Stephan, B\u00f6sm\u00fcller Hans, Fend Falko, Kohlbacher Oliver, Gouttefangeas C\u00e9cile, Stevanovi\u0107 Stefan, K\u00f6nigsrainer Alfred, Rammensee Hans-Georg", "evidence": [ { "database": "IEDB", "id": "426187", "url": "https://www.iedb.org/epitope/426187" } ], "reference": [ { "type": "PubMed", "id": "27397612", "url": "https://glygen.org/publication/PubMed/27397612" } ] }, { "title": "Mass spectrometric analysis of the HLA class I peptidome of melanoma cell lines as a promising tool for the identification of putative tumor-associated HLA epitopes.", "journal": "Cancer immunology, immunotherapy : CII", "date": "2016-11", "authors": "Gloger Andreas, Ritz Danilo, Fugmann Tim, Neri Dario", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "543334", "url": "https://www.iedb.org/epitope/543334" } ], "reference": [ { "type": "PubMed", "id": "27600516", "url": "https://glygen.org/publication/PubMed/27600516" } ] }, { "title": "Dengue Virus Infection Is through a Cooperative Interaction between a Mannose Receptor and CLEC5A on Macrophage as a Multivalent Hetero-Complex.", "journal": "PloS one", "date": "2016", "authors": "Lo YL, Liou GG, Lyu JH, Hsiao M, Hsu TL, Wong CH", "evidence": [ { "database": "Reactome", "id": "R-HSA-9920588", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9920588" } ], "reference": [ { "type": "PubMed", "id": "27832191", "url": "https://glygen.org/publication/PubMed/27832191" } ] }, { "title": "A large fraction of HLA class I ligands are proteasome-generated spliced peptides.", "journal": "Science (New York, N.Y.)", "date": "2016-10-21", "authors": "Liepe Juliane, Marino Fabio, Sidney John, Jeko Anita, Bunting Daniel E, Sette Alessandro, Kloetzel Peter M, Stumpf Michael P H, Heck Albert J R, Mishto Michele", "evidence": [ { "database": "IEDB", "id": "431157", "url": "https://www.iedb.org/epitope/431157" }, { "database": "IEDB", "id": "479903", "url": "https://www.iedb.org/epitope/479903" }, { "database": "IEDB", "id": "583773", "url": "https://www.iedb.org/epitope/583773" }, { "database": "IEDB", "id": "590329", "url": "https://www.iedb.org/epitope/590329" } ], "reference": [ { "type": "PubMed", "id": "27846572", "url": "https://glygen.org/publication/PubMed/27846572" } ] }, { "title": "Purification of soluble HLA class I complexes from human serum or plasma deliver high quality immuno peptidomes required for biomarker discovery.", "journal": "Proteomics", "date": "2017-01", "authors": "Ritz Danilo, Gloger Andreas, Neri Dario, Fugmann Tim", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "705980", "url": "https://www.iedb.org/epitope/705980" }, { "database": "IEDB", "id": "717602", "url": "https://www.iedb.org/epitope/717602" }, { "database": "IEDB", "id": "955934", "url": "https://www.iedb.org/epitope/955934" }, { "database": "IEDB", "id": "956074", "url": "https://www.iedb.org/epitope/956074" } ], "reference": [ { "type": "PubMed", "id": "27862975", "url": "https://glygen.org/publication/PubMed/27862975" } ] }, { "title": "A Molecular Basis for the Presentation of Phosphorylated Peptides by HLA-B Antigens.", "journal": "Molecular & cellular proteomics : MCP", "date": "2017-02", "authors": "Alp\u00edzar Ad\u00e1n, Marino Fabio, Ramos-Fern\u00e1ndez Antonio, Lombard\u00eda Manuel, Jeko Anita, Pazos Florencio, Paradela Alberto, Santiago C\u00e9sar, Heck Albert J R, Marcilla Miguel", "evidence": [ { "database": "IEDB", "id": "224160", "url": "https://www.iedb.org/epitope/224160" }, { "database": "IEDB", "id": "466305", "url": "https://www.iedb.org/epitope/466305" }, { "database": "IEDB", "id": "491519", "url": "https://www.iedb.org/epitope/491519" }, { "database": "IEDB", "id": "583773", "url": "https://www.iedb.org/epitope/583773" }, { "database": "IEDB", "id": "607787", "url": "https://www.iedb.org/epitope/607787" }, { "database": "IEDB", "id": "607837", "url": "https://www.iedb.org/epitope/607837" }, { "database": "IEDB", "id": "608036", "url": "https://www.iedb.org/epitope/608036" }, { "database": "IEDB", "id": "608661", "url": "https://www.iedb.org/epitope/608661" }, { "database": "IEDB", "id": "612254", "url": "https://www.iedb.org/epitope/612254" } ], "reference": [ { "type": "PubMed", "id": "27920218", "url": "https://glygen.org/publication/PubMed/27920218" } ] }, { "title": "Separate effects of the ankylosing spondylitis associated ERAP1 and ERAP2 aminopeptidases determine the influence of their combined phenotype on the HLA-B*27 peptidome.", "journal": "Journal of autoimmunity", "date": "2017-05", "authors": "Mart\u00edn-Esteban Adrian, Sanz-Bravo Alejandro, Guasp Pablo, Barnea Eilon, Admon Arie, L\u00f3pez de Castro Jos\u00e9 A", "evidence": [ { "database": "IEDB", "id": "241528", "url": "https://www.iedb.org/epitope/241528" } ], "reference": [ { "type": "PubMed", "id": "28063628", "url": "https://glygen.org/publication/PubMed/28063628" } ] }, { "title": "MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape.", "journal": "Nature structural & molecular biology", "date": "2017-04", "authors": "Pymm Phillip, Illing Patricia T, Ramarathinam Sri H, O'Connor Geraldine M, Hughes Victoria A, Hitchen Corinne, Price David A, Ho Bosco K, McVicar Daniel W, Brooks Andrew G, Purcell Anthony W, Rossjohn Jamie, Vivian Julian P", "evidence": [ { "database": "IEDB", "id": "175897", "url": "https://www.iedb.org/epitope/175897" }, { "database": "IEDB", "id": "594293", "url": "https://www.iedb.org/epitope/594293" }, { "database": "IEDB", "id": "594541", "url": "https://www.iedb.org/epitope/594541" }, { "database": "IEDB", "id": "596376", "url": "https://www.iedb.org/epitope/596376" }, { "database": "IEDB", "id": "597216", "url": "https://www.iedb.org/epitope/597216" }, { "database": "IEDB", "id": "598276", "url": "https://www.iedb.org/epitope/598276" }, { "database": "IEDB", "id": "598851", "url": "https://www.iedb.org/epitope/598851" }, { "database": "IEDB", "id": "599393", "url": "https://www.iedb.org/epitope/599393" }, { "database": "IEDB", "id": "602658", "url": "https://www.iedb.org/epitope/602658" }, { "database": "IEDB", "id": "603242", "url": "https://www.iedb.org/epitope/603242" }, { "database": "IEDB", "id": "603889", "url": "https://www.iedb.org/epitope/603889" } ], "reference": [ { "type": "PubMed", "id": "28218747", "url": "https://glygen.org/publication/PubMed/28218747" } ] }, { "title": "Mass Spectrometry Profiling of HLA-Associated Peptidomes in Mono-allelic Cells Enables More Accurate Epitope Prediction.", "journal": "Immunity", "date": "2017-02-21", "authors": "Abelin Jennifer G, Keskin Derin B, Sarkizova Siranush, Hartigan Christina R, Zhang Wandi, Sidney John, Stevens Jonathan, Lane William, Zhang Guang Lan, Eisenhaure Thomas M, Clauser Karl R, Hacohen Nir, Rooney Michael S, Carr Steven A, Wu Catherine J", "evidence": [ { "database": "IEDB", "id": "175897", "url": "https://www.iedb.org/epitope/175897" }, { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "436141", "url": "https://www.iedb.org/epitope/436141" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "444312", "url": "https://www.iedb.org/epitope/444312" }, { "database": "IEDB", "id": "446446", "url": "https://www.iedb.org/epitope/446446" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "505055", "url": "https://www.iedb.org/epitope/505055" }, { "database": "IEDB", "id": "509968", "url": "https://www.iedb.org/epitope/509968" }, { "database": "IEDB", "id": "629436", "url": "https://www.iedb.org/epitope/629436" }, { "database": "IEDB", "id": "630675", "url": "https://www.iedb.org/epitope/630675" }, { "database": "IEDB", "id": "633879", "url": "https://www.iedb.org/epitope/633879" }, { "database": "IEDB", "id": "634102", "url": "https://www.iedb.org/epitope/634102" }, { "database": "IEDB", "id": "634137", "url": "https://www.iedb.org/epitope/634137" }, { "database": "IEDB", "id": "634481", "url": "https://www.iedb.org/epitope/634481" }, { "database": "IEDB", "id": "637055", "url": "https://www.iedb.org/epitope/637055" } ], "reference": [ { "type": "PubMed", "id": "28228285", "url": "https://glygen.org/publication/PubMed/28228285" } ] }, { "title": "The Beh\u00e7et's disease-associated variant of the aminopeptidase ERAP1 shapes a low-affinity HLA-B*51 peptidome by differential subpeptidome processing.", "journal": "The Journal of biological chemistry", "date": "2017-06-09", "authors": "Guasp Pablo, Barnea Eilon, Gonz\u00e1lez-Escribano M Francisca, Jim\u00e9nez-Reinoso Ana\u00efs, Regueiro Jos\u00e9 R, Admon Arie, L\u00f3pez de Castro Jos\u00e9 A", "evidence": [ { "database": "IEDB", "id": "446446", "url": "https://www.iedb.org/epitope/446446" } ], "reference": [ { "type": "PubMed", "id": "28446606", "url": "https://glygen.org/publication/PubMed/28446606" } ] }, { "title": "The Intergenic Recombinant HLA-B *46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands.", "journal": "Cell reports", "date": "2017", "authors": "Hilton HG, McMurtrey CP, Han AS, Djaoud Z, Guethlein LA, Blokhuis JH, Pugh JL, Goyos A, Horowitz A, Buchli R, Jackson KW, Bardet W, Bushnell DA, Robinson PJ, Mendoza JL, Birnbaum ME, Nielsen M, Garcia KC, Hildebrand WH, Parham P", "evidence": [ { "database": "IEDB", "id": "441519", "url": "https://www.iedb.org/epitope/441519" }, { "database": "IEDB", "id": "640633", "url": "https://www.iedb.org/epitope/640633" }, { "database": "IEDB", "id": "640634", "url": "https://www.iedb.org/epitope/640634" }, { "database": "IEDB", "id": "644976", "url": "https://www.iedb.org/epitope/644976" }, { "database": "IEDB", "id": "645125", "url": "https://www.iedb.org/epitope/645125" }, { "database": "IEDB", "id": "646870", "url": "https://www.iedb.org/epitope/646870" }, { "database": "IEDB", "id": "649439", "url": "https://www.iedb.org/epitope/649439" }, { "database": "IEDB", "id": "651868", "url": "https://www.iedb.org/epitope/651868" }, { "database": "IEDB", "id": "652125", "url": "https://www.iedb.org/epitope/652125" }, { "database": "IEDB", "id": "652546", "url": "https://www.iedb.org/epitope/652546" } ], "reference": [ { "type": "PubMed", "id": "28514659", "url": "https://glygen.org/publication/PubMed/28514659" } ] }, { "title": "Structural and regulatory diversity shape HLA-C protein expression levels.", "journal": "Nature communications", "date": "2017", "authors": "Kaur G, Gras S, Mobbs JI, Vivian JP, Cortes A, Barber T, Kuttikkatte SB, Jensen LT, Attfield KE, Dendrou CA, Carrington M, McVean G, Purcell AW, Rossjohn J, Fugger L", "evidence": [ { "database": "IEDB", "id": "541918", "url": "https://www.iedb.org/epitope/541918" }, { "database": "IEDB", "id": "692247", "url": "https://www.iedb.org/epitope/692247" }, { "database": "IEDB", "id": "692404", "url": "https://www.iedb.org/epitope/692404" } ], "reference": [ { "type": "PubMed", "id": "28649982", "url": "https://glygen.org/publication/PubMed/28649982" } ] }, { "title": "Association of rs1285933 single nucleotide polymorphism in CLEC5A gene with dengue severity and its functional effects.", "journal": "Human immunology", "date": "2017", "authors": "Xavier-Carvalho C, Cezar RDDS, Freire NM, Vasconcelos CMM, Solorzano VEF, de Toledo-Pinto TG, Fialho LG, do Carmo RF, Vasconcelos LRS, Cordeiro MT, Baptista P, de Azeredo EL, da Cunha RV, de Souza LJ, Pacheco AG, Kubelka CF, Moura PMMF, Moraes MO", "evidence": [ { "database": "Reactome", "id": "R-HSA-9920588", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9920588" } ], "reference": [ { "type": "PubMed", "id": "28764923", "url": "https://glygen.org/publication/PubMed/28764923" } ] }, { "title": "Deciphering HLA-I motifs across HLA peptidomes improves neo-antigen predictions and identifies allostery regulating HLA specificity.", "journal": "PLoS computational biology", "date": "2017-08", "authors": "Bassani-Sternberg Michal, Chong Chlo\u00e9, Guillaume Philippe, Solleder Marthe, Pak HuiSong, Gannon Philippe O, Kandalaft Lana E, Coukos George, Gfeller David", "evidence": [ { "database": "IEDB", "id": "162846", "url": "https://www.iedb.org/epitope/162846" }, { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "436141", "url": "https://www.iedb.org/epitope/436141" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "441519", "url": "https://www.iedb.org/epitope/441519" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "457112", "url": "https://www.iedb.org/epitope/457112" }, { "database": "IEDB", "id": "459480", "url": "https://www.iedb.org/epitope/459480" }, { "database": "IEDB", "id": "486924", "url": "https://www.iedb.org/epitope/486924" }, { "database": "IEDB", "id": "505055", "url": "https://www.iedb.org/epitope/505055" }, { "database": "IEDB", "id": "577812", "url": "https://www.iedb.org/epitope/577812" }, { "database": "IEDB", "id": "607837", "url": "https://www.iedb.org/epitope/607837" }, { "database": "IEDB", "id": "622086", "url": "https://www.iedb.org/epitope/622086" }, { "database": "IEDB", "id": "651868", "url": "https://www.iedb.org/epitope/651868" }, { "database": "IEDB", "id": "703316", "url": "https://www.iedb.org/epitope/703316" }, { "database": "IEDB", "id": "705980", "url": "https://www.iedb.org/epitope/705980" }, { "database": "IEDB", "id": "707990", "url": "https://www.iedb.org/epitope/707990" }, { "database": "IEDB", "id": "720948", "url": "https://www.iedb.org/epitope/720948" }, { "database": "IEDB", "id": "724573", "url": "https://www.iedb.org/epitope/724573" } ], "reference": [ { "type": "PubMed", "id": "28832583", "url": "https://glygen.org/publication/PubMed/28832583" } ] }, { "title": "Data-Independent Acquisition of HLA Class I Peptidomes on the Q Exactive Mass Spectrometer Platform.", "journal": "Proteomics", "date": "2017-10", "authors": "Ritz Danilo, Kinzi Jonny, Neri Dario, Fugmann Tim", "evidence": [ { "database": "IEDB", "id": "203328", "url": "https://www.iedb.org/epitope/203328" }, { "database": "IEDB", "id": "219588", "url": "https://www.iedb.org/epitope/219588" }, { "database": "IEDB", "id": "436141", "url": "https://www.iedb.org/epitope/436141" }, { "database": "IEDB", "id": "457112", "url": "https://www.iedb.org/epitope/457112" }, { "database": "IEDB", "id": "607837", "url": "https://www.iedb.org/epitope/607837" }, { "database": "IEDB", "id": "733934", "url": "https://www.iedb.org/epitope/733934" }, { "database": "IEDB", "id": "735106", "url": "https://www.iedb.org/epitope/735106" } ], "reference": [ { "type": "PubMed", "id": "28834231", "url": "https://glygen.org/publication/PubMed/28834231" } ] }, { "title": "The major histocompatibility complex class I immunopeptidome of extracellular vesicles.", "journal": "The Journal of biological chemistry", "date": "2017-10-13", "authors": "Synowsky Silvia A, Shirran Sally L, Cooke Fiona G M, Antoniou Antony N, Botting Catherine H, Powis Simon J", "evidence": [ { "database": "IEDB", "id": "241528", "url": "https://www.iedb.org/epitope/241528" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" } ], "reference": [ { "type": "PubMed", "id": "28860189", "url": "https://glygen.org/publication/PubMed/28860189" } ] }, { "title": "Unveiling the Peptide Motifs of HLA-C and HLA-G from Naturally Presented Peptides and Generation of Binding Prediction Matrices.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2017-10-15", "authors": "Di Marco Moreno, Schuster Heiko, Backert Linus, Ghosh Michael, Rammensee Hans-Georg, Stevanovi\u0107 Stefan", "evidence": [ { "database": "IEDB", "id": "481713", "url": "https://www.iedb.org/epitope/481713" }, { "database": "IEDB", "id": "541918", "url": "https://www.iedb.org/epitope/541918" }, { "database": "IEDB", "id": "545530", "url": "https://www.iedb.org/epitope/545530" }, { "database": "IEDB", "id": "545843", "url": "https://www.iedb.org/epitope/545843" }, { "database": "IEDB", "id": "603889", "url": "https://www.iedb.org/epitope/603889" }, { "database": "IEDB", "id": "608131", "url": "https://www.iedb.org/epitope/608131" }, { "database": "IEDB", "id": "692247", "url": "https://www.iedb.org/epitope/692247" }, { "database": "IEDB", "id": "692404", "url": "https://www.iedb.org/epitope/692404" }, { "database": "IEDB", "id": "699700", "url": "https://www.iedb.org/epitope/699700" }, { "database": "IEDB", "id": "700312", "url": "https://www.iedb.org/epitope/700312" }, { "database": "IEDB", "id": "704794", "url": "https://www.iedb.org/epitope/704794" }, { "database": "IEDB", "id": "705809", "url": "https://www.iedb.org/epitope/705809" }, { "database": "IEDB", "id": "708560", "url": "https://www.iedb.org/epitope/708560" }, { "database": "IEDB", "id": "708628", "url": "https://www.iedb.org/epitope/708628" }, { "database": "IEDB", "id": "711817", "url": "https://www.iedb.org/epitope/711817" }, { "database": "IEDB", "id": "711991", "url": "https://www.iedb.org/epitope/711991" }, { "database": "IEDB", "id": "712009", "url": "https://www.iedb.org/epitope/712009" }, { "database": "IEDB", "id": "715305", "url": "https://www.iedb.org/epitope/715305" }, { "database": "IEDB", "id": "718332", "url": "https://www.iedb.org/epitope/718332" }, { "database": "IEDB", "id": "724350", "url": "https://www.iedb.org/epitope/724350" }, { "database": "IEDB", "id": "727008", "url": "https://www.iedb.org/epitope/727008" }, { "database": "IEDB", "id": "727950", "url": "https://www.iedb.org/epitope/727950" }, { "database": "IEDB", "id": "729587", "url": "https://www.iedb.org/epitope/729587" }, { "database": "IEDB", "id": "729857", "url": "https://www.iedb.org/epitope/729857" }, { "database": "IEDB", "id": "729976", "url": "https://www.iedb.org/epitope/729976" }, { "database": "IEDB", "id": "731467", "url": "https://www.iedb.org/epitope/731467" }, { "database": "IEDB", "id": "732383", "url": "https://www.iedb.org/epitope/732383" }, { "database": "IEDB", "id": "732522", "url": "https://www.iedb.org/epitope/732522" } ], "reference": [ { "type": "PubMed", "id": "28904123", "url": "https://glygen.org/publication/PubMed/28904123" } ] }, { "title": "Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control.", "journal": "Cell", "date": "2017-11-02", "authors": "Yau Richard G, Doerner Kerstin, Castellanos Erick R, Haakonsen Diane L, Werner Achim, Wang Nan, Yang X William, Martinez-Martin Nadia, Matsumoto Marissa L, Dixit Vishva M, Rape Michael", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "reference": [ { "type": "PubMed", "id": "29033132", "url": "https://glygen.org/publication/PubMed/29033132" } ] }, { "title": "High-throughput and Sensitive Immunopeptidomics Platform Reveals Profound Interferon\u03b3-Mediated Remodeling of the Human Leukocyte Antigen (HLA) Ligandome.", "journal": "Molecular & cellular proteomics : MCP", "date": "2018-03", "authors": "Chong Chloe, Marino Fabio, Pak HuiSong, Racle Julien, Daniel Roy T, M\u00fcller Markus, Gfeller David, Coukos George, Bassani-Sternberg Michal", "evidence": [ { "database": "IEDB", "id": "162846", "url": "https://www.iedb.org/epitope/162846" }, { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "447449", "url": "https://www.iedb.org/epitope/447449" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "459480", "url": "https://www.iedb.org/epitope/459480" }, { "database": "IEDB", "id": "486924", "url": "https://www.iedb.org/epitope/486924" }, { "database": "IEDB", "id": "505055", "url": "https://www.iedb.org/epitope/505055" }, { "database": "IEDB", "id": "542799", "url": "https://www.iedb.org/epitope/542799" }, { "database": "IEDB", "id": "577760", "url": "https://www.iedb.org/epitope/577760" }, { "database": "IEDB", "id": "583773", "url": "https://www.iedb.org/epitope/583773" }, { "database": "IEDB", "id": "607837", "url": "https://www.iedb.org/epitope/607837" }, { "database": "IEDB", "id": "622086", "url": "https://www.iedb.org/epitope/622086" }, { "database": "IEDB", "id": "651868", "url": "https://www.iedb.org/epitope/651868" }, { "database": "IEDB", "id": "705980", "url": "https://www.iedb.org/epitope/705980" }, { "database": "IEDB", "id": "707990", "url": "https://www.iedb.org/epitope/707990" }, { "database": "IEDB", "id": "720948", "url": "https://www.iedb.org/epitope/720948" }, { "database": "IEDB", "id": "727008", "url": "https://www.iedb.org/epitope/727008" }, { "database": "IEDB", "id": "992370", "url": "https://www.iedb.org/epitope/992370" }, { "database": "IEDB", "id": "1045035", "url": "https://www.iedb.org/epitope/1045035" }, { "database": "IEDB", "id": "1061653", "url": "https://www.iedb.org/epitope/1061653" }, { "database": "IEDB", "id": "1326078", "url": "https://www.iedb.org/epitope/1326078" }, { "database": "IEDB", "id": "1887254", "url": "https://www.iedb.org/epitope/1887254" }, { "database": "IEDB", "id": "1888126", "url": "https://www.iedb.org/epitope/1888126" }, { "database": "IEDB", "id": "1913318", "url": "https://www.iedb.org/epitope/1913318" }, { "database": "IEDB", "id": "1920091", "url": "https://www.iedb.org/epitope/1920091" }, { "database": "IEDB", "id": "1932795", "url": "https://www.iedb.org/epitope/1932795" }, { "database": "IEDB", "id": "1944369", "url": "https://www.iedb.org/epitope/1944369" } ], "reference": [ { "type": "PubMed", "id": "29242379", "url": "https://glygen.org/publication/PubMed/29242379" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q5T4S7", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q5T4S7" }, { "database": "O-GlcNAc Atlas", "id": "Q5T4S7", "url": "https://oglcnac.org/atlas/detail/Q5T4S7" }, { "database": "Data Submission", "id": "GLY_000142", "url": "http://data.glygen.org/GLY_000142" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "The Peptide Repertoire of HLA-B27 may include Ligands with Lysine at P2 Anchor Position.", "journal": "Proteomics", "date": "2018-05", "authors": "Yair-Sabag Shira, Tedeschi Valentina, Vitulano Carolina, Barnea Eilon, Glaser Fabian, Melamed Kadosh Dganit, Taurog Joel D, Fiorillo Maria Teresa, Sorrentino Rosa, Admon Arie", "evidence": [ { "database": "IEDB", "id": "241528", "url": "https://www.iedb.org/epitope/241528" }, { "database": "IEDB", "id": "445228", "url": "https://www.iedb.org/epitope/445228" }, { "database": "IEDB", "id": "491519", "url": "https://www.iedb.org/epitope/491519" }, { "database": "IEDB", "id": "493110", "url": "https://www.iedb.org/epitope/493110" }, { "database": "IEDB", "id": "603889", "url": "https://www.iedb.org/epitope/603889" }, { "database": "IEDB", "id": "670785", "url": "https://www.iedb.org/epitope/670785" }, { "database": "IEDB", "id": "673939", "url": "https://www.iedb.org/epitope/673939" } ], "reference": [ { "type": "PubMed", "id": "29393594", "url": "https://glygen.org/publication/PubMed/29393594" } ] }, { "title": "Identification of Native and Posttranslationally Modified HLA-B*57:01-Restricted HIV Envelope Derived Epitopes Using Immunoproteomics.", "journal": "Proteomics", "date": "2018-06", "authors": "Ramarathinam Sri H, Gras Stephanie, Alcantara Sheilajen, Yeung Amanda W S, Mifsud Nicole A, Sonza Secondo, Illing Patricia T, Glaros Elias N, Center Robert J, Thomas Shane R, Kent Stephen J, Ternette Nicola, Purcell Damian F J, Rossjohn Jamie, Purcell Anthony W", "evidence": [ { "database": "IEDB", "id": "175897", "url": "https://www.iedb.org/epitope/175897" }, { "database": "IEDB", "id": "593857", "url": "https://www.iedb.org/epitope/593857" }, { "database": "IEDB", "id": "597216", "url": "https://www.iedb.org/epitope/597216" }, { "database": "IEDB", "id": "597219", "url": "https://www.iedb.org/epitope/597219" }, { "database": "IEDB", "id": "598276", "url": "https://www.iedb.org/epitope/598276" }, { "database": "IEDB", "id": "602658", "url": "https://www.iedb.org/epitope/602658" }, { "database": "IEDB", "id": "603250", "url": "https://www.iedb.org/epitope/603250" } ], "reference": [ { "type": "PubMed", "id": "29437277", "url": "https://glygen.org/publication/PubMed/29437277" } ] }, { "title": "T-Cell Immunopeptidomes Reveal Cell Subtype Surface Markers Derived From Intracellular Proteins.", "journal": "Proteomics", "date": "2018-06", "authors": "Olsson Niclas, Schultz Liora M, Zhang Lichao, Khodadoust Michael S, Narayan Rupa, Czerwinski Debra K, Levy Ronald, Elias Joshua E", "evidence": [ { "database": "IEDB", "id": "175897", "url": "https://www.iedb.org/epitope/175897" }, { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "431157", "url": "https://www.iedb.org/epitope/431157" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "575426", "url": "https://www.iedb.org/epitope/575426" }, { "database": "IEDB", "id": "598276", "url": "https://www.iedb.org/epitope/598276" }, { "database": "IEDB", "id": "926906", "url": "https://www.iedb.org/epitope/926906" } ], "reference": [ { "type": "PubMed", "id": "29493099", "url": "https://glygen.org/publication/PubMed/29493099" } ] }, { "title": "Comparison of the MHC I Immunopeptidome Repertoire of B-Cell Lymphoblasts Using Two Isolation Methods.", "journal": "Proteomics", "date": "2018-06", "authors": "Lanoix Jo\u00ebl, Durette Chantal, Courcelles Mathieu, Cossette \u00c9milie, Comtois-Marotte Simon, Hardy Marie-Pierre, C\u00f4t\u00e9 Caroline, Perreault Claude, Thibault Pierre", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "436141", "url": "https://www.iedb.org/epitope/436141" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "542799", "url": "https://www.iedb.org/epitope/542799" } ], "reference": [ { "type": "PubMed", "id": "29508533", "url": "https://glygen.org/publication/PubMed/29508533" } ] }, { "title": "The natural HLA ligandome of glioblastoma stem-like cells: antigen discovery for T cell-based immunotherapy.", "journal": "Acta neuropathologica", "date": "2018-06", "authors": "Neidert Marian Christoph, Kowalewski Daniel Johannes, Silginer Manuela, Kapolou Konstantina, Backert Linus, Freudenmann Lena Katharina, Peper Janet Kerstin, Marcu Ana, Wang Sophie Shih-Y\u00fcng, Walz Juliane Sarah, Wolpert Fabian, Rammensee Hans-Georg, Henschler Reinhard, Lamszus Katrin, Westphal Manfred, Roth Patrick, Regli Luca, Stevanovi\u0107 Stefan, Weller Michael, Eisele G\u00fcnter", "evidence": [ { "database": "IEDB", "id": "175897", "url": "https://www.iedb.org/epitope/175897" }, { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "241528", "url": "https://www.iedb.org/epitope/241528" }, { "database": "IEDB", "id": "426187", "url": "https://www.iedb.org/epitope/426187" }, { "database": "IEDB", "id": "436384", "url": "https://www.iedb.org/epitope/436384" }, { "database": "IEDB", "id": "437318", "url": "https://www.iedb.org/epitope/437318" }, { "database": "IEDB", "id": "441519", "url": "https://www.iedb.org/epitope/441519" }, { "database": "IEDB", "id": "446446", "url": "https://www.iedb.org/epitope/446446" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "509357", "url": "https://www.iedb.org/epitope/509357" }, { "database": "IEDB", "id": "575387", "url": "https://www.iedb.org/epitope/575387" }, { "database": "IEDB", "id": "583773", "url": "https://www.iedb.org/epitope/583773" }, { "database": "IEDB", "id": "607837", "url": "https://www.iedb.org/epitope/607837" }, { "database": "IEDB", "id": "622086", "url": "https://www.iedb.org/epitope/622086" }, { "database": "IEDB", "id": "643857", "url": "https://www.iedb.org/epitope/643857" }, { "database": "IEDB", "id": "699405", "url": "https://www.iedb.org/epitope/699405" }, { "database": "IEDB", "id": "707990", "url": "https://www.iedb.org/epitope/707990" }, { "database": "IEDB", "id": "718575", "url": "https://www.iedb.org/epitope/718575" }, { "database": "IEDB", "id": "772977", "url": "https://www.iedb.org/epitope/772977" }, { "database": "IEDB", "id": "875784", "url": "https://www.iedb.org/epitope/875784" }, { "database": "IEDB", "id": "892512", "url": "https://www.iedb.org/epitope/892512" }, { "database": "IEDB", "id": "1088245", "url": "https://www.iedb.org/epitope/1088245" }, { "database": "IEDB", "id": "1102949", "url": "https://www.iedb.org/epitope/1102949" }, { "database": "IEDB", "id": "1105727", "url": "https://www.iedb.org/epitope/1105727" }, { "database": "IEDB", "id": "1111500", "url": "https://www.iedb.org/epitope/1111500" }, { "database": "IEDB", "id": "1118129", "url": "https://www.iedb.org/epitope/1118129" } ], "reference": [ { "type": "PubMed", "id": "29557506", "url": "https://glygen.org/publication/PubMed/29557506" } ] }, { "title": "Ranking the Contribution of Ankylosing Spondylitis-associated Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Polymorphisms to Shaping the HLA-B*27 Peptidome.", "journal": "Molecular & cellular proteomics : MCP", "date": "2018-07", "authors": "Sanz-Bravo Alejandro, Alvarez-Navarro Carlos, Mart\u00edn-Esteban Adrian, Barnea Eilon, Admon Arie, L\u00f3pez de Castro Jos\u00e9 A", "evidence": [ { "database": "IEDB", "id": "241528", "url": "https://www.iedb.org/epitope/241528" }, { "database": "IEDB", "id": "490433", "url": "https://www.iedb.org/epitope/490433" }, { "database": "IEDB", "id": "491519", "url": "https://www.iedb.org/epitope/491519" }, { "database": "IEDB", "id": "495864", "url": "https://www.iedb.org/epitope/495864" }, { "database": "IEDB", "id": "670785", "url": "https://www.iedb.org/epitope/670785" } ], "reference": [ { "type": "PubMed", "id": "29632046", "url": "https://glygen.org/publication/PubMed/29632046" } ] }, { "title": "HLA ligandome analysis of primary chronic lymphocytic leukemia (CLL) cells under lenalidomide treatment confirms the suitability of lenalidomide for combination with T-cell-based immunotherapy.", "journal": "Oncoimmunology", "date": "2018", "authors": "Nelde Annika, Kowalewski Daniel J, Backert Linus, Schuster Heiko, Werner Jan-Ole, Klein Reinhild, Kohlbacher Oliver, Kanz Lothar, Salih Helmut R, Rammensee Hans-Georg, Stevanovi\u0107 Stefan, Walz Juliane S", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "446446", "url": "https://www.iedb.org/epitope/446446" }, { "database": "IEDB", "id": "486924", "url": "https://www.iedb.org/epitope/486924" } ], "reference": [ { "type": "PubMed", "id": "29632711", "url": "https://glygen.org/publication/PubMed/29632711" } ] }, { "title": "Allele-specific Alterations in the Peptidome Underlie the Joint Association of HLA-A*29:02 and Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) with Birdshot Chorioretinopathy.", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Sanz-Bravo A, Martin-Esteban A, Kuiper JJW, Garcia-Peydro M, Barnea E, Admon A, Lopez de Castro JA", "evidence": [ { "database": "IEDB", "id": "425406", "url": "https://www.iedb.org/epitope/425406" }, { "database": "IEDB", "id": "427293", "url": "https://www.iedb.org/epitope/427293" } ], "reference": [ { "type": "PubMed", "id": "29769354", "url": "https://glygen.org/publication/PubMed/29769354" } ] }, { "title": "Immunopeptidomic Profiling of HLA-A2-Positive Triple Negative Breast Cancer Identifies Potential Immunotherapy Target Antigens.", "journal": "Proteomics", "date": "2018-06", "authors": "Ternette Nicola, Olde Nordkamp Marloes J M, M\u00fcller Julius, Anderson Amanda P, Nicastri Annalisa, Hill Adrian V S, Kessler Benedikt M, Li Demin", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "241528", "url": "https://www.iedb.org/epitope/241528" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "446446", "url": "https://www.iedb.org/epitope/446446" }, { "database": "IEDB", "id": "447449", "url": "https://www.iedb.org/epitope/447449" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "509357", "url": "https://www.iedb.org/epitope/509357" }, { "database": "IEDB", "id": "651868", "url": "https://www.iedb.org/epitope/651868" }, { "database": "IEDB", "id": "772134", "url": "https://www.iedb.org/epitope/772134" }, { "database": "IEDB", "id": "774038", "url": "https://www.iedb.org/epitope/774038" }, { "database": "IEDB", "id": "779756", "url": "https://www.iedb.org/epitope/779756" } ], "reference": [ { "type": "PubMed", "id": "29786170", "url": "https://glygen.org/publication/PubMed/29786170" } ] }, { "title": "A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands.", "journal": "Science immunology", "date": "2018-10-12", "authors": "Faridi Pouya, Li Chen, Ramarathinam Sri H, Vivian Julian P, Illing Patricia T, Mifsud Nicole A, Ayala Rochelle, Song Jiangning, Gearing Linden J, Hertzog Paul J, Ternette Nicola, Rossjohn Jamie, Croft Nathan P, Purcell Anthony W", "evidence": [ { "database": "IEDB", "id": "431157", "url": "https://www.iedb.org/epitope/431157" }, { "database": "IEDB", "id": "437318", "url": "https://www.iedb.org/epitope/437318" }, { "database": "IEDB", "id": "444312", "url": "https://www.iedb.org/epitope/444312" }, { "database": "IEDB", "id": "447449", "url": "https://www.iedb.org/epitope/447449" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "459480", "url": "https://www.iedb.org/epitope/459480" }, { "database": "IEDB", "id": "505055", "url": "https://www.iedb.org/epitope/505055" }, { "database": "IEDB", "id": "603889", "url": "https://www.iedb.org/epitope/603889" }, { "database": "IEDB", "id": "705980", "url": "https://www.iedb.org/epitope/705980" }, { "database": "IEDB", "id": "896332", "url": "https://www.iedb.org/epitope/896332" } ], "reference": [ { "type": "PubMed", "id": "30315122", "url": "https://glygen.org/publication/PubMed/30315122" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q5T4S7", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q5T4S7" }, { "database": "O-GlcNAc Atlas", "id": "Q5T4S7", "url": "https://oglcnac.org/atlas/detail/Q5T4S7" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome.", "journal": "Nature communications", "date": "2018-11-08", "authors": "Illing Patricia T, Pymm Phillip, Croft Nathan P, Hilton Hugo G, Jojic Vladimir, Han Alex S, Mendoza Juan L, Mifsud Nicole A, Dudek Nadine L, McCluskey James, Parham Peter, Rossjohn Jamie, Vivian Julian P, Purcell Anthony W", "evidence": [ { "database": "IEDB", "id": "175897", "url": "https://www.iedb.org/epitope/175897" }, { "database": "IEDB", "id": "593857", "url": "https://www.iedb.org/epitope/593857" }, { "database": "IEDB", "id": "594293", "url": "https://www.iedb.org/epitope/594293" }, { "database": "IEDB", "id": "597216", "url": "https://www.iedb.org/epitope/597216" }, { "database": "IEDB", "id": "602658", "url": "https://www.iedb.org/epitope/602658" }, { "database": "IEDB", "id": "705809", "url": "https://www.iedb.org/epitope/705809" }, { "database": "IEDB", "id": "860602", "url": "https://www.iedb.org/epitope/860602" } ], "reference": [ { "type": "PubMed", "id": "30410026", "url": "https://glygen.org/publication/PubMed/30410026" } ] }, { "title": "The Length Distribution and Multiple Specificity of Naturally Presented HLA-I Ligands.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2018-12-15", "authors": "Gfeller David, Guillaume Philippe, Michaux Justine, Pak Hui-Song, Daniel Roy T, Racle Julien, Coukos George, Bassani-Sternberg Michal", "evidence": [ { "database": "IEDB", "id": "479903", "url": "https://www.iedb.org/epitope/479903" }, { "database": "IEDB", "id": "578286", "url": "https://www.iedb.org/epitope/578286" }, { "database": "IEDB", "id": "583773", "url": "https://www.iedb.org/epitope/583773" }, { "database": "IEDB", "id": "607837", "url": "https://www.iedb.org/epitope/607837" }, { "database": "IEDB", "id": "643857", "url": "https://www.iedb.org/epitope/643857" }, { "database": "IEDB", "id": "651868", "url": "https://www.iedb.org/epitope/651868" }, { "database": "IEDB", "id": "718515", "url": "https://www.iedb.org/epitope/718515" }, { "database": "IEDB", "id": "879595", "url": "https://www.iedb.org/epitope/879595" }, { "database": "IEDB", "id": "884934", "url": "https://www.iedb.org/epitope/884934" } ], "reference": [ { "type": "PubMed", "id": "30429286", "url": "https://glygen.org/publication/PubMed/30429286" } ] }, { "title": "TAPBPR mediates peptide dissociation from MHC class I using a leucine lever.", "journal": "eLife", "date": "2018", "authors": "Ilca FT, Neerincx A, Hermann C, Marcu A, Stevanovic S, Deane JE, Boyle LH", "evidence": [ { "database": "IEDB", "id": "505055", "url": "https://www.iedb.org/epitope/505055" }, { "database": "IEDB", "id": "630675", "url": "https://www.iedb.org/epitope/630675" } ], "reference": [ { "type": "PubMed", "id": "30484775", "url": "https://glygen.org/publication/PubMed/30484775" } ] }, { "title": "Specific MHC-I Peptides Are Induced Using PROTACs.", "journal": "Frontiers in immunology", "date": "2018", "authors": "Jensen Stephanie M, Potts Gregory K, Ready Damien B, Patterson Melanie J", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "542799", "url": "https://www.iedb.org/epitope/542799" }, { "database": "IEDB", "id": "575460", "url": "https://www.iedb.org/epitope/575460" }, { "database": "IEDB", "id": "622086", "url": "https://www.iedb.org/epitope/622086" }, { "database": "IEDB", "id": "867304", "url": "https://www.iedb.org/epitope/867304" }, { "database": "IEDB", "id": "868263", "url": "https://www.iedb.org/epitope/868263" }, { "database": "IEDB", "id": "868287", "url": "https://www.iedb.org/epitope/868287" }, { "database": "IEDB", "id": "868388", "url": "https://www.iedb.org/epitope/868388" }, { "database": "IEDB", "id": "868923", "url": "https://www.iedb.org/epitope/868923" }, { "database": "IEDB", "id": "868955", "url": "https://www.iedb.org/epitope/868955" } ], "reference": [ { "type": "PubMed", "id": "30524438", "url": "https://glygen.org/publication/PubMed/30524438" } ] }, { "title": "Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis.", "journal": "Cell", "date": "2018", "authors": "Shah PS, Link N, Jang GM, Sharp PP, Zhu T, Swaney DL, Johnson JR, Von Dollen J, Ramage HR, Satkamp L, Newton B, Huttenhain R, Petit MJ, Baum T, Everitt A, Laufman O, Tassetto M, Shales M, Stevenson E, Iglesias GN, Shokat L, Tripathi S, Balasubramaniam V, Webb LG, Aguirre S, Willsey AJ, Garcia-Sastre A, Pollard KS, Cherry S, Gamarnik AV, Marazzi I, Taunton J, Fernandez-Sesma A, Bellen HJ, Andino R, Krogan NJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9920588", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9920588" } ], "reference": [ { "type": "PubMed", "id": "30550790", "url": "https://glygen.org/publication/PubMed/30550790" } ] }, { "title": "Naturally processed HLA-DR3-restricted HHV-6B peptides are recognized broadly with polyfunctional and cytotoxic CD4 T-cell responses.", "journal": "European journal of immunology", "date": "2019-08", "authors": "Becerra-Artiles Aniuska, Cruz John, Leszyk John D, Sidney John, Sette Alessandro, Shaffer Scott A, Stern Lawrence J", "evidence": [ { "database": "IEDB", "id": "921438", "url": "https://www.iedb.org/epitope/921438" } ], "reference": [ { "type": "PubMed", "id": "31020640", "url": "https://glygen.org/publication/PubMed/31020640" } ] }, { "title": "Identification of Immunodominant HIV-1 Epitopes Presented by HLA-C*12:02, a Protective Allele, Using an Immunopeptidomics Approach.", "journal": "Journal of virology", "date": "2019-09-01", "authors": "Chikata Takayuki, Paes Wayne, Akahoshi Tomohiro, Partridge Thomas, Murakoshi Hayato, Gatanaga Hiroyuki, Ternette Nicola, Oka Shinichi, Borrow Persephone, Takiguchi Masafumi", "evidence": [ { "database": "IEDB", "id": "481713", "url": "https://www.iedb.org/epitope/481713" }, { "database": "IEDB", "id": "892512", "url": "https://www.iedb.org/epitope/892512" }, { "database": "IEDB", "id": "924571", "url": "https://www.iedb.org/epitope/924571" }, { "database": "IEDB", "id": "929442", "url": "https://www.iedb.org/epitope/929442" }, { "database": "IEDB", "id": "929615", "url": "https://www.iedb.org/epitope/929615" }, { "database": "IEDB", "id": "930793", "url": "https://www.iedb.org/epitope/930793" } ], "reference": [ { "type": "PubMed", "id": "31217245", "url": "https://glygen.org/publication/PubMed/31217245" } ] }, { "title": "High-throughput peptide-MHC complex generation and kinetic screenings of TCRs with peptide-receptive HLA-A*02:01 molecules.", "journal": "Science immunology", "date": "2019-07-19", "authors": "Moritz Andreas, Anjanappa Raghavendra, Wagner Claudia, Bunk Sebastian, Hofmann Martin, Pszolla Gabriele, Saikia Ankur, Garcia-Alai Maria, Meijers Rob, Rammensee Hans-Georg, Springer Sebastian, Maurer Dominik", "evidence": [ { "database": "IEDB", "id": "1714867", "url": "https://www.iedb.org/epitope/1714867" } ], "reference": [ { "type": "PubMed", "id": "31324691", "url": "https://glygen.org/publication/PubMed/31324691" } ] }, { "title": "Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.", "journal": "Nature communications", "date": "2019", "authors": "Hao Y, Fan X, Shi Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q5T4S7", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q5T4S7" }, { "database": "O-GlcNAc Atlas", "id": "Q5T4S7", "url": "https://oglcnac.org/atlas/detail/Q5T4S7" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "A large peptidome dataset improves HLA class I epitope prediction across most of the human population.", "journal": "Nature biotechnology", "date": "2020-02", "authors": "Sarkizova Siranush, Klaeger Susan, Le Phuong M, Li Letitia W, Oliveira Giacomo, Keshishian Hasmik, Hartigan Christina R, Zhang Wandi, Braun David A, Ligon Keith L, Bachireddy Pavan, Zervantonakis Ioannis K, Rosenbluth Jennifer M, Ouspenskaia Tamara, Law Travis, Justesen Sune, Stevens Jonathan, Lane William J, Eisenhaure Thomas, Lan Zhang Guang, Clauser Karl R, Hacohen Nir, Carr Steven A, Wu Catherine J, Keskin Derin B", "evidence": [ { "database": "IEDB", "id": "175897", "url": "https://www.iedb.org/epitope/175897" }, { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "224160", "url": "https://www.iedb.org/epitope/224160" }, { "database": "IEDB", "id": "426187", "url": "https://www.iedb.org/epitope/426187" }, { "database": "IEDB", "id": "436141", "url": "https://www.iedb.org/epitope/436141" }, { "database": "IEDB", "id": "436384", "url": "https://www.iedb.org/epitope/436384" }, { "database": "IEDB", "id": "437318", "url": "https://www.iedb.org/epitope/437318" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "441072", "url": "https://www.iedb.org/epitope/441072" }, { "database": "IEDB", "id": "441519", "url": "https://www.iedb.org/epitope/441519" }, { "database": "IEDB", "id": "443759", "url": "https://www.iedb.org/epitope/443759" }, { "database": "IEDB", "id": "444312", "url": "https://www.iedb.org/epitope/444312" }, { "database": "IEDB", "id": "446446", "url": "https://www.iedb.org/epitope/446446" }, { "database": "IEDB", "id": "447449", "url": "https://www.iedb.org/epitope/447449" }, { "database": "IEDB", "id": "448851", "url": "https://www.iedb.org/epitope/448851" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "466305", "url": "https://www.iedb.org/epitope/466305" }, { "database": "IEDB", "id": "468285", "url": "https://www.iedb.org/epitope/468285" }, { "database": "IEDB", "id": "479903", "url": "https://www.iedb.org/epitope/479903" }, { "database": "IEDB", "id": "481713", "url": "https://www.iedb.org/epitope/481713" }, { "database": "IEDB", "id": "485565", "url": "https://www.iedb.org/epitope/485565" }, { "database": "IEDB", "id": "486924", "url": "https://www.iedb.org/epitope/486924" }, { "database": "IEDB", "id": "490433", "url": "https://www.iedb.org/epitope/490433" }, { "database": "IEDB", "id": "505055", "url": "https://www.iedb.org/epitope/505055" }, { "database": "IEDB", "id": "509357", "url": "https://www.iedb.org/epitope/509357" }, { "database": "IEDB", "id": "509968", "url": "https://www.iedb.org/epitope/509968" }, { "database": "IEDB", "id": "541918", "url": "https://www.iedb.org/epitope/541918" }, { "database": "IEDB", "id": "542799", "url": "https://www.iedb.org/epitope/542799" }, { "database": "IEDB", "id": "545530", "url": "https://www.iedb.org/epitope/545530" }, { "database": "IEDB", "id": "545843", "url": "https://www.iedb.org/epitope/545843" }, { "database": "IEDB", "id": "575426", "url": "https://www.iedb.org/epitope/575426" }, { "database": "IEDB", "id": "575460", "url": "https://www.iedb.org/epitope/575460" }, { "database": "IEDB", "id": "578116", "url": "https://www.iedb.org/epitope/578116" }, { "database": "IEDB", "id": "583773", "url": "https://www.iedb.org/epitope/583773" }, { "database": "IEDB", "id": "594293", "url": "https://www.iedb.org/epitope/594293" }, { "database": "IEDB", "id": "597216", "url": "https://www.iedb.org/epitope/597216" }, { "database": "IEDB", "id": "603889", "url": "https://www.iedb.org/epitope/603889" }, { "database": "IEDB", "id": "607787", "url": "https://www.iedb.org/epitope/607787" }, { "database": "IEDB", "id": "607837", "url": "https://www.iedb.org/epitope/607837" }, { "database": "IEDB", "id": "608131", "url": "https://www.iedb.org/epitope/608131" }, { "database": "IEDB", "id": "608661", "url": "https://www.iedb.org/epitope/608661" }, { "database": "IEDB", "id": "612254", "url": "https://www.iedb.org/epitope/612254" }, { "database": "IEDB", "id": "620554", "url": "https://www.iedb.org/epitope/620554" }, { "database": "IEDB", "id": "622086", "url": "https://www.iedb.org/epitope/622086" }, { "database": "IEDB", "id": "629369", "url": "https://www.iedb.org/epitope/629369" }, { "database": "IEDB", "id": "629436", "url": "https://www.iedb.org/epitope/629436" }, { "database": "IEDB", "id": "630184", "url": "https://www.iedb.org/epitope/630184" }, { "database": "IEDB", "id": "630675", "url": "https://www.iedb.org/epitope/630675" }, { "database": "IEDB", "id": "633879", "url": "https://www.iedb.org/epitope/633879" }, { "database": "IEDB", "id": "634137", "url": "https://www.iedb.org/epitope/634137" }, { "database": "IEDB", "id": "634481", "url": "https://www.iedb.org/epitope/634481" }, { "database": "IEDB", "id": "637055", "url": "https://www.iedb.org/epitope/637055" }, { "database": "IEDB", "id": "640633", "url": "https://www.iedb.org/epitope/640633" }, { "database": "IEDB", "id": "643857", "url": "https://www.iedb.org/epitope/643857" }, { "database": "IEDB", "id": "681461", "url": "https://www.iedb.org/epitope/681461" }, { "database": "IEDB", "id": "691691", "url": "https://www.iedb.org/epitope/691691" }, { "database": "IEDB", "id": "692404", "url": "https://www.iedb.org/epitope/692404" }, { "database": "IEDB", "id": "699405", "url": "https://www.iedb.org/epitope/699405" }, { "database": "IEDB", "id": "704794", "url": "https://www.iedb.org/epitope/704794" }, { "database": "IEDB", "id": "705809", "url": "https://www.iedb.org/epitope/705809" }, { "database": "IEDB", "id": "705980", "url": "https://www.iedb.org/epitope/705980" }, { "database": "IEDB", "id": "707990", "url": "https://www.iedb.org/epitope/707990" }, { "database": "IEDB", "id": "711139", "url": "https://www.iedb.org/epitope/711139" }, { "database": "IEDB", "id": "715305", "url": "https://www.iedb.org/epitope/715305" }, { "database": "IEDB", "id": "717602", "url": "https://www.iedb.org/epitope/717602" }, { "database": "IEDB", "id": "718515", "url": "https://www.iedb.org/epitope/718515" }, { "database": "IEDB", "id": "718575", "url": "https://www.iedb.org/epitope/718575" }, { "database": "IEDB", "id": "724350", "url": "https://www.iedb.org/epitope/724350" }, { "database": "IEDB", "id": "727008", "url": "https://www.iedb.org/epitope/727008" }, { "database": "IEDB", "id": "729587", "url": "https://www.iedb.org/epitope/729587" }, { "database": "IEDB", "id": "729857", "url": "https://www.iedb.org/epitope/729857" }, { "database": "IEDB", "id": "733934", "url": "https://www.iedb.org/epitope/733934" }, { "database": "IEDB", "id": "734569", "url": "https://www.iedb.org/epitope/734569" }, { "database": "IEDB", "id": "866511", "url": "https://www.iedb.org/epitope/866511" }, { "database": "IEDB", "id": "884958", "url": "https://www.iedb.org/epitope/884958" }, { "database": "IEDB", "id": "892512", "url": "https://www.iedb.org/epitope/892512" }, { "database": "IEDB", "id": "955028", "url": "https://www.iedb.org/epitope/955028" }, { "database": "IEDB", "id": "955934", "url": "https://www.iedb.org/epitope/955934" }, { "database": "IEDB", "id": "987675", "url": "https://www.iedb.org/epitope/987675" }, { "database": "IEDB", "id": "998482", "url": "https://www.iedb.org/epitope/998482" }, { "database": "IEDB", "id": "1000534", "url": "https://www.iedb.org/epitope/1000534" }, { "database": "IEDB", "id": "1000821", "url": "https://www.iedb.org/epitope/1000821" }, { "database": "IEDB", "id": "1002536", "url": "https://www.iedb.org/epitope/1002536" }, { "database": "IEDB", "id": "1003125", "url": "https://www.iedb.org/epitope/1003125" }, { "database": "IEDB", "id": "1007382", "url": "https://www.iedb.org/epitope/1007382" }, { "database": "IEDB", "id": "1008189", "url": "https://www.iedb.org/epitope/1008189" }, { "database": "IEDB", "id": "1010874", "url": "https://www.iedb.org/epitope/1010874" }, { "database": "IEDB", "id": "1011213", "url": "https://www.iedb.org/epitope/1011213" }, { "database": "IEDB", "id": "1015000", "url": "https://www.iedb.org/epitope/1015000" }, { "database": "IEDB", "id": "1015859", "url": "https://www.iedb.org/epitope/1015859" }, { "database": "IEDB", "id": "1017584", "url": "https://www.iedb.org/epitope/1017584" }, { "database": "IEDB", "id": "1019500", "url": "https://www.iedb.org/epitope/1019500" }, { "database": "IEDB", "id": "1020947", "url": "https://www.iedb.org/epitope/1020947" }, { "database": "IEDB", "id": "1023235", "url": "https://www.iedb.org/epitope/1023235" }, { "database": "IEDB", "id": "1023659", "url": "https://www.iedb.org/epitope/1023659" }, { "database": "IEDB", "id": "1025973", "url": "https://www.iedb.org/epitope/1025973" }, { "database": "IEDB", "id": "1034285", "url": "https://www.iedb.org/epitope/1034285" }, { "database": "IEDB", "id": "1037231", "url": "https://www.iedb.org/epitope/1037231" }, { "database": "IEDB", "id": "1037463", "url": "https://www.iedb.org/epitope/1037463" }, { "database": "IEDB", "id": "1042621", "url": "https://www.iedb.org/epitope/1042621" }, { "database": "IEDB", "id": "1044031", "url": "https://www.iedb.org/epitope/1044031" }, { "database": "IEDB", "id": "1045035", "url": "https://www.iedb.org/epitope/1045035" }, { "database": "IEDB", "id": "1051506", "url": "https://www.iedb.org/epitope/1051506" }, { "database": "IEDB", "id": "1052525", "url": "https://www.iedb.org/epitope/1052525" }, { "database": "IEDB", "id": "1059190", "url": "https://www.iedb.org/epitope/1059190" }, { "database": "IEDB", "id": "1061653", "url": "https://www.iedb.org/epitope/1061653" }, { "database": "IEDB", "id": "1061654", "url": "https://www.iedb.org/epitope/1061654" }, { "database": "IEDB", "id": "1062709", "url": "https://www.iedb.org/epitope/1062709" } ], "reference": [ { "type": "PubMed", "id": "31844290", "url": "https://glygen.org/publication/PubMed/31844290" } ] }, { "title": "CLEC2 and CLEC5A: Pathogenic Host Factors in Acute Viral Infections.", "journal": "Frontiers in immunology", "date": "2019", "authors": "Sung PS, Hsieh SL", "evidence": [ { "database": "Reactome", "id": "R-HSA-9920588", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9920588" } ], "reference": [ { "type": "PubMed", "id": "31867016", "url": "https://glygen.org/publication/PubMed/31867016" } ] }, { "title": "CLEC5A: A Promiscuous Pattern Recognition Receptor to Microbes and Beyond.", "journal": "Advances in experimental medicine and biology", "date": "2020", "authors": "Sung PS, Chang WC, Hsieh SL", "evidence": [ { "database": "Reactome", "id": "R-HSA-9920588", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9920588" } ], "reference": [ { "type": "PubMed", "id": "32152943", "url": "https://glygen.org/publication/PubMed/32152943" } ] }, { "title": "Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes.", "journal": "Nature communications", "date": "2020-03-10", "authors": "Chong Chloe, M\u00fcller Markus, Pak HuiSong, Harnett Dermot, Huber Florian, Grun Delphine, Leleu Marion, Auger Aymeric, Arnaud Marion, Stevenson Brian J, Michaux Justine, Bilic Ilija, Hirsekorn Antje, Calviello Lorenzo, Sim\u00f3-Riudalbas Laia, Planet Evarist, Lubi\u0144ski Jan, Bry\u015bkiewicz Marta, Wiznerowicz Maciej, Xenarios Ioannis, Zhang Lin, Trono Didier, Harari Alexandre, Ohler Uwe, Coukos George, Bassani-Sternberg Michal", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "436384", "url": "https://www.iedb.org/epitope/436384" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "443759", "url": "https://www.iedb.org/epitope/443759" }, { "database": "IEDB", "id": "447449", "url": "https://www.iedb.org/epitope/447449" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "481713", "url": "https://www.iedb.org/epitope/481713" }, { "database": "IEDB", "id": "484733", "url": "https://www.iedb.org/epitope/484733" }, { "database": "IEDB", "id": "485565", "url": "https://www.iedb.org/epitope/485565" }, { "database": "IEDB", "id": "486924", "url": "https://www.iedb.org/epitope/486924" }, { "database": "IEDB", "id": "505055", "url": "https://www.iedb.org/epitope/505055" }, { "database": "IEDB", "id": "542799", "url": "https://www.iedb.org/epitope/542799" }, { "database": "IEDB", "id": "575426", "url": "https://www.iedb.org/epitope/575426" }, { "database": "IEDB", "id": "607837", "url": "https://www.iedb.org/epitope/607837" }, { "database": "IEDB", "id": "643857", "url": "https://www.iedb.org/epitope/643857" }, { "database": "IEDB", "id": "699405", "url": "https://www.iedb.org/epitope/699405" }, { "database": "IEDB", "id": "707990", "url": "https://www.iedb.org/epitope/707990" }, { "database": "IEDB", "id": "720948", "url": "https://www.iedb.org/epitope/720948" }, { "database": "IEDB", "id": "726694", "url": "https://www.iedb.org/epitope/726694" }, { "database": "IEDB", "id": "772977", "url": "https://www.iedb.org/epitope/772977" }, { "database": "IEDB", "id": "875784", "url": "https://www.iedb.org/epitope/875784" }, { "database": "IEDB", "id": "879595", "url": "https://www.iedb.org/epitope/879595" }, { "database": "IEDB", "id": "884169", "url": "https://www.iedb.org/epitope/884169" }, { "database": "IEDB", "id": "884958", "url": "https://www.iedb.org/epitope/884958" }, { "database": "IEDB", "id": "926906", "url": "https://www.iedb.org/epitope/926906" }, { "database": "IEDB", "id": "947914", "url": "https://www.iedb.org/epitope/947914" }, { "database": "IEDB", "id": "950966", "url": "https://www.iedb.org/epitope/950966" }, { "database": "IEDB", "id": "1000821", "url": "https://www.iedb.org/epitope/1000821" }, { "database": "IEDB", "id": "1019500", "url": "https://www.iedb.org/epitope/1019500" }, { "database": "IEDB", "id": "1037463", "url": "https://www.iedb.org/epitope/1037463" }, { "database": "IEDB", "id": "1045035", "url": "https://www.iedb.org/epitope/1045035" }, { "database": "IEDB", "id": "1168155", "url": "https://www.iedb.org/epitope/1168155" }, { "database": "IEDB", "id": "1325569", "url": "https://www.iedb.org/epitope/1325569" }, { "database": "IEDB", "id": "1603594", "url": "https://www.iedb.org/epitope/1603594" }, { "database": "IEDB", "id": "2061302", "url": "https://www.iedb.org/epitope/2061302" }, { "database": "IEDB", "id": "2061396", "url": "https://www.iedb.org/epitope/2061396" }, { "database": "IEDB", "id": "2062096", "url": "https://www.iedb.org/epitope/2062096" }, { "database": "IEDB", "id": "2063865", "url": "https://www.iedb.org/epitope/2063865" }, { "database": "IEDB", "id": "2068009", "url": "https://www.iedb.org/epitope/2068009" }, { "database": "IEDB", "id": "2068254", "url": "https://www.iedb.org/epitope/2068254" }, { "database": "IEDB", "id": "2069665", "url": "https://www.iedb.org/epitope/2069665" } ], "reference": [ { "type": "PubMed", "id": "32157095", "url": "https://glygen.org/publication/PubMed/32157095" } ] }, { "title": "Modulation of Natural HLA-B*27:05 Ligandome by Ankylosing Spondylitis-associated Endoplasmic Reticulum Aminopeptidase 2 (ERAP2).", "journal": "Molecular & cellular proteomics : MCP", "date": "2020-06", "authors": "Lorente Elena, Fontela Miguel G, Barnea Eilon, Mart\u00edn-Galiano Antonio J, Mir Carmen, Galocha Bego\u00f1a, Admon Arie, Lauzurica Pilar, L\u00f3pez Daniel", "evidence": [ { "database": "IEDB", "id": "241528", "url": "https://www.iedb.org/epitope/241528" }, { "database": "IEDB", "id": "448851", "url": "https://www.iedb.org/epitope/448851" }, { "database": "IEDB", "id": "491519", "url": "https://www.iedb.org/epitope/491519" }, { "database": "IEDB", "id": "492526", "url": "https://www.iedb.org/epitope/492526" }, { "database": "IEDB", "id": "495081", "url": "https://www.iedb.org/epitope/495081" }, { "database": "IEDB", "id": "670785", "url": "https://www.iedb.org/epitope/670785" }, { "database": "IEDB", "id": "777141", "url": "https://www.iedb.org/epitope/777141" }, { "database": "IEDB", "id": "1084185", "url": "https://www.iedb.org/epitope/1084185" } ], "reference": [ { "type": "PubMed", "id": "32265295", "url": "https://glygen.org/publication/PubMed/32265295" } ] }, { "title": "Immunopeptidome Analysis of HLA-DPB1 Allelic Variants Reveals New Functional Hierarchies.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2020-06-15", "authors": "van Balen Peter, Kester Michel G D, de Klerk Wendy, Crivello Pietro, Arrieta-Bola\u00f1os Esteban, de Ru Arnoud H, Jedema Inge, Mohammed Yassene, Heemskerk Mirjam H M, Fleischhauer Katharina, van Veelen Peter A, Falkenburg J H Frederik", "evidence": [ { "database": "IEDB", "id": "436141", "url": "https://www.iedb.org/epitope/436141" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "543334", "url": "https://www.iedb.org/epitope/543334" }, { "database": "IEDB", "id": "1131306", "url": "https://www.iedb.org/epitope/1131306" }, { "database": "IEDB", "id": "1131307", "url": "https://www.iedb.org/epitope/1131307" }, { "database": "IEDB", "id": "1134320", "url": "https://www.iedb.org/epitope/1134320" }, { "database": "IEDB", "id": "1160879", "url": "https://www.iedb.org/epitope/1160879" }, { "database": "IEDB", "id": "1165703", "url": "https://www.iedb.org/epitope/1165703" }, { "database": "IEDB", "id": "1168155", "url": "https://www.iedb.org/epitope/1168155" }, { "database": "IEDB", "id": "1168156", "url": "https://www.iedb.org/epitope/1168156" } ], "reference": [ { "type": "PubMed", "id": "32350084", "url": "https://glygen.org/publication/PubMed/32350084" } ] }, { "title": "Immunopeptidomic Analysis Reveals That Deamidated HLA-bound Peptides Arise Predominantly from Deglycosylated Precursors.", "journal": "Molecular & cellular proteomics : MCP", "date": "2020-07", "authors": "Mei Shutao, Ayala Rochelle, Ramarathinam Sri H, Illing Patricia T, Faridi Pouya, Song Jiangning, Purcell Anthony W, Croft Nathan P", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "437318", "url": "https://www.iedb.org/epitope/437318" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "441072", "url": "https://www.iedb.org/epitope/441072" }, { "database": "IEDB", "id": "447449", "url": "https://www.iedb.org/epitope/447449" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "468571", "url": "https://www.iedb.org/epitope/468571" }, { "database": "IEDB", "id": "469366", "url": "https://www.iedb.org/epitope/469366" }, { "database": "IEDB", "id": "471269", "url": "https://www.iedb.org/epitope/471269" }, { "database": "IEDB", "id": "471688", "url": "https://www.iedb.org/epitope/471688" }, { "database": "IEDB", "id": "504446", "url": "https://www.iedb.org/epitope/504446" }, { "database": "IEDB", "id": "542799", "url": "https://www.iedb.org/epitope/542799" }, { "database": "IEDB", "id": "545696", "url": "https://www.iedb.org/epitope/545696" }, { "database": "IEDB", "id": "603889", "url": "https://www.iedb.org/epitope/603889" }, { "database": "IEDB", "id": "692247", "url": "https://www.iedb.org/epitope/692247" }, { "database": "IEDB", "id": "705809", "url": "https://www.iedb.org/epitope/705809" }, { "database": "IEDB", "id": "707990", "url": "https://www.iedb.org/epitope/707990" }, { "database": "IEDB", "id": "732522", "url": "https://www.iedb.org/epitope/732522" }, { "database": "IEDB", "id": "939489", "url": "https://www.iedb.org/epitope/939489" }, { "database": "IEDB", "id": "1000821", "url": "https://www.iedb.org/epitope/1000821" }, { "database": "IEDB", "id": "1015859", "url": "https://www.iedb.org/epitope/1015859" }, { "database": "IEDB", "id": "1020947", "url": "https://www.iedb.org/epitope/1020947" }, { "database": "IEDB", "id": "1037463", "url": "https://www.iedb.org/epitope/1037463" }, { "database": "IEDB", "id": "1061653", "url": "https://www.iedb.org/epitope/1061653" }, { "database": "IEDB", "id": "1061654", "url": "https://www.iedb.org/epitope/1061654" }, { "database": "IEDB", "id": "1315692", "url": "https://www.iedb.org/epitope/1315692" }, { "database": "IEDB", "id": "1315758", "url": "https://www.iedb.org/epitope/1315758" }, { "database": "IEDB", "id": "1316156", "url": "https://www.iedb.org/epitope/1316156" }, { "database": "IEDB", "id": "1316662", "url": "https://www.iedb.org/epitope/1316662" }, { "database": "IEDB", "id": "1317891", "url": "https://www.iedb.org/epitope/1317891" }, { "database": "IEDB", "id": "1318029", "url": "https://www.iedb.org/epitope/1318029" }, { "database": "IEDB", "id": "1319178", "url": "https://www.iedb.org/epitope/1319178" }, { "database": "IEDB", "id": "1321441", "url": "https://www.iedb.org/epitope/1321441" }, { "database": "IEDB", "id": "1324271", "url": "https://www.iedb.org/epitope/1324271" }, { "database": "IEDB", "id": "1325569", "url": "https://www.iedb.org/epitope/1325569" }, { "database": "IEDB", "id": "1326078", "url": "https://www.iedb.org/epitope/1326078" }, { "database": "IEDB", "id": "1328012", "url": "https://www.iedb.org/epitope/1328012" } ], "reference": [ { "type": "PubMed", "id": "32357974", "url": "https://glygen.org/publication/PubMed/32357974" } ] }, { "title": "In-depth mining of the immunopeptidome of an acute myeloid leukemia cell line using complementary ligand enrichment and data acquisition strategies.", "journal": "Molecular immunology", "date": "2020-07", "authors": "Pandey Kirti, Mifsud Nicole A, Lim Kam Sian Terry C C, Ayala Rochelle, Ternette Nicola, Ramarathinam Sri H, Purcell Anthony W", "evidence": [ { "database": "iPTMnet", "id": "Q5T4S7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5T4S7" }, { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "241528", "url": "https://www.iedb.org/epitope/241528" }, { "database": "IEDB", "id": "437318", "url": "https://www.iedb.org/epitope/437318" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "441072", "url": "https://www.iedb.org/epitope/441072" }, { "database": "IEDB", "id": "444312", "url": "https://www.iedb.org/epitope/444312" }, { "database": "IEDB", "id": "447449", "url": "https://www.iedb.org/epitope/447449" }, { "database": "IEDB", "id": "448851", "url": "https://www.iedb.org/epitope/448851" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "471688", "url": "https://www.iedb.org/epitope/471688" }, { "database": "IEDB", "id": "481713", "url": "https://www.iedb.org/epitope/481713" }, { "database": "IEDB", "id": "490433", "url": "https://www.iedb.org/epitope/490433" }, { "database": "IEDB", "id": "491519", "url": "https://www.iedb.org/epitope/491519" }, { "database": "IEDB", "id": "492526", "url": "https://www.iedb.org/epitope/492526" }, { "database": "IEDB", "id": "495081", "url": "https://www.iedb.org/epitope/495081" }, { "database": "IEDB", "id": "504446", "url": "https://www.iedb.org/epitope/504446" }, { "database": "IEDB", "id": "542799", "url": "https://www.iedb.org/epitope/542799" }, { "database": "IEDB", "id": "545696", "url": "https://www.iedb.org/epitope/545696" }, { "database": "IEDB", "id": "652546", "url": "https://www.iedb.org/epitope/652546" }, { "database": "IEDB", "id": "892512", "url": "https://www.iedb.org/epitope/892512" }, { "database": "IEDB", "id": "955028", "url": "https://www.iedb.org/epitope/955028" }, { "database": "IEDB", "id": "1000821", "url": "https://www.iedb.org/epitope/1000821" }, { "database": "IEDB", "id": "1015859", "url": "https://www.iedb.org/epitope/1015859" }, { "database": "IEDB", "id": "1020947", "url": "https://www.iedb.org/epitope/1020947" }, { "database": "IEDB", "id": "1061653", "url": "https://www.iedb.org/epitope/1061653" }, { "database": "IEDB", "id": "1088245", "url": "https://www.iedb.org/epitope/1088245" }, { "database": "IEDB", "id": "1348492", "url": "https://www.iedb.org/epitope/1348492" }, { "database": "IEDB", "id": "1348637", "url": "https://www.iedb.org/epitope/1348637" }, { "database": "IEDB", "id": "1350577", "url": "https://www.iedb.org/epitope/1350577" }, { "database": "IEDB", "id": "1351755", "url": "https://www.iedb.org/epitope/1351755" }, { "database": "IEDB", "id": "1355441", "url": "https://www.iedb.org/epitope/1355441" }, { "database": "IEDB", "id": "1357715", "url": "https://www.iedb.org/epitope/1357715" }, { "database": "IEDB", "id": "1358163", "url": "https://www.iedb.org/epitope/1358163" }, { "database": "IEDB", "id": "1361696", "url": "https://www.iedb.org/epitope/1361696" }, { "database": "IEDB", "id": "1362020", "url": "https://www.iedb.org/epitope/1362020" }, { "database": "IEDB", "id": "1363299", "url": "https://www.iedb.org/epitope/1363299" }, { "database": "IEDB", "id": "1363307", "url": "https://www.iedb.org/epitope/1363307" }, { "database": "IEDB", "id": "1363574", "url": "https://www.iedb.org/epitope/1363574" }, { "database": "IEDB", "id": "1368158", "url": "https://www.iedb.org/epitope/1368158" }, { "database": "IEDB", "id": "1368512", "url": "https://www.iedb.org/epitope/1368512" }, { "database": "IEDB", "id": "1372800", "url": "https://www.iedb.org/epitope/1372800" }, { "database": "IEDB", "id": "1373066", "url": "https://www.iedb.org/epitope/1373066" }, { "database": "IEDB", "id": "1373954", "url": "https://www.iedb.org/epitope/1373954" }, { "database": "IEDB", "id": "1373958", "url": "https://www.iedb.org/epitope/1373958" }, { "database": "IEDB", "id": "1374509", "url": "https://www.iedb.org/epitope/1374509" }, { "database": "IEDB", "id": "1376237", "url": "https://www.iedb.org/epitope/1376237" }, { "database": "IEDB", "id": "1376362", "url": "https://www.iedb.org/epitope/1376362" } ], "reference": [ { "type": "PubMed", "id": "32387766", "url": "https://glygen.org/publication/PubMed/32387766" } ] }, { "title": "Dengue virus targets RBM10 deregulating host cell splicing and innate immune response.", "journal": "Nucleic acids research", "date": "2020", "authors": "Pozzi B, Bragado L, Mammi P, Torti MF, Gaioli N, Gebhard LG, Garcia Sola ME, Vaz-Drago R, Iglesias NG, Garcia CC, Gamarnik AV, Srebrow A", "evidence": [ { "database": "Reactome", "id": "R-HSA-9920588", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9920588" } ], "reference": [ { "type": "PubMed", "id": "32432721", "url": "https://glygen.org/publication/PubMed/32432721" } ] }, { "title": "Multiplexed relative and absolute quantitative immunopeptidomics reveals MHC I repertoire alterations induced by CDK4/6 inhibition.", "journal": "Nature communications", "date": "2020-06-02", "authors": "Stopfer Lauren E, Mesfin Joshua M, Joughin Brian A, Lauffenburger Douglas A, White Forest M", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "437318", "url": "https://www.iedb.org/epitope/437318" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "464922", "url": "https://www.iedb.org/epitope/464922" }, { "database": "IEDB", "id": "485565", "url": "https://www.iedb.org/epitope/485565" }, { "database": "IEDB", "id": "578286", "url": "https://www.iedb.org/epitope/578286" }, { "database": "IEDB", "id": "607837", "url": "https://www.iedb.org/epitope/607837" }, { "database": "IEDB", "id": "892512", "url": "https://www.iedb.org/epitope/892512" }, { "database": "IEDB", "id": "950966", "url": "https://www.iedb.org/epitope/950966" }, { "database": "IEDB", "id": "951665", "url": "https://www.iedb.org/epitope/951665" }, { "database": "IEDB", "id": "1083641", "url": "https://www.iedb.org/epitope/1083641" }, { "database": "IEDB", "id": "1084169", "url": "https://www.iedb.org/epitope/1084169" }, { "database": "IEDB", "id": "1084293", "url": "https://www.iedb.org/epitope/1084293" }, { "database": "IEDB", "id": "1086412", "url": "https://www.iedb.org/epitope/1086412" } ], "reference": [ { "type": "PubMed", "id": "32488085", "url": "https://glygen.org/publication/PubMed/32488085" } ] }, { "title": "Extending the Comprehensiveness of Immunopeptidome Analyses Using Isobaric Peptide Labeling.", "journal": "Analytical chemistry", "date": "2020-07-07", "authors": "Pfammatter Sibylle, Bonneil Eric, Lanoix Joel, Vincent Krystel, Hardy Marie-Pierre, Courcelles Mathieu, Perreault Claude, Thibault Pierre", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "436141", "url": "https://www.iedb.org/epitope/436141" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "443759", "url": "https://www.iedb.org/epitope/443759" }, { "database": "IEDB", "id": "447449", "url": "https://www.iedb.org/epitope/447449" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "575387", "url": "https://www.iedb.org/epitope/575387" }, { "database": "IEDB", "id": "612254", "url": "https://www.iedb.org/epitope/612254" }, { "database": "IEDB", "id": "724680", "url": "https://www.iedb.org/epitope/724680" }, { "database": "IEDB", "id": "950966", "url": "https://www.iedb.org/epitope/950966" }, { "database": "IEDB", "id": "953668", "url": "https://www.iedb.org/epitope/953668" }, { "database": "IEDB", "id": "1340424", "url": "https://www.iedb.org/epitope/1340424" }, { "database": "IEDB", "id": "1340985", "url": "https://www.iedb.org/epitope/1340985" }, { "database": "IEDB", "id": "1342815", "url": "https://www.iedb.org/epitope/1342815" } ], "reference": [ { "type": "PubMed", "id": "32502341", "url": "https://glygen.org/publication/PubMed/32502341" } ] }, { "title": "Structural basis for STAT2 suppression by flavivirus NS5.", "journal": "Nature structural & molecular biology", "date": "2020-10", "authors": "Wang Boxiao, Thurmond Stephanie, Zhou Kang, S\u00e1nchez-Aparicio Maria T, Fang Jian, Lu Jiuwei, Gao Linfeng, Ren Wendan, Cui Yanxiang, Veit Ethan C, Hong HeaJin, Evans Matthew J, O'Leary Se\u00e1n E, Garc\u00eda-Sastre Adolfo, Zhou Z Hong, Hai Rong, Song Jikui", "evidence": [ { "database": "Reactome", "id": "R-HSA-9920588", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9920588" } ], "reference": [ { "type": "PubMed", "id": "32778820", "url": "https://glygen.org/publication/PubMed/32778820" } ] }, { "title": "Solving an MHC allele-specific bias in the reported immunopeptidome.", "journal": "JCI insight", "date": "2020-10-02", "authors": "Klatt Martin G, Mack Kyeara N, Bai Yang, Aretz Zita E H, Nathan Levy I, Mun Sung Soo, Dao Tao, Scheinberg David A", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "437318", "url": "https://www.iedb.org/epitope/437318" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "441072", "url": "https://www.iedb.org/epitope/441072" }, { "database": "IEDB", "id": "446446", "url": "https://www.iedb.org/epitope/446446" }, { "database": "IEDB", "id": "447449", "url": "https://www.iedb.org/epitope/447449" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "479903", "url": "https://www.iedb.org/epitope/479903" }, { "database": "IEDB", "id": "509357", "url": "https://www.iedb.org/epitope/509357" }, { "database": "IEDB", "id": "575460", "url": "https://www.iedb.org/epitope/575460" }, { "database": "IEDB", "id": "577760", "url": "https://www.iedb.org/epitope/577760" }, { "database": "IEDB", "id": "622086", "url": "https://www.iedb.org/epitope/622086" }, { "database": "IEDB", "id": "643857", "url": "https://www.iedb.org/epitope/643857" }, { "database": "IEDB", "id": "718515", "url": "https://www.iedb.org/epitope/718515" }, { "database": "IEDB", "id": "866511", "url": "https://www.iedb.org/epitope/866511" }, { "database": "IEDB", "id": "869162", "url": "https://www.iedb.org/epitope/869162" }, { "database": "IEDB", "id": "2140354", "url": "https://www.iedb.org/epitope/2140354" } ], "reference": [ { "type": "PubMed", "id": "32897882", "url": "https://glygen.org/publication/PubMed/32897882" } ] }, { "title": "Spliced Peptides and Cytokine-Driven Changes in the Immunopeptidome of Melanoma.", "journal": "Cancer immunology research", "date": "2020-10", "authors": "Faridi Pouya, Woods Katherine, Ostrouska Simone, Deceneux Cyril, Aranha Ritchlynn, Duscharla Divya, Wong Stephen Q, Chen Weisan, Ramarathinam Sri H, Lim Kam Sian Terry C C, Croft Nathan P, Li Chen, Ayala Rochelle, Cebon Jonathan S, Purcell Anthony W, Schittenhelm Ralf B, Behren Andreas", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "436141", "url": "https://www.iedb.org/epitope/436141" }, { "database": "IEDB", "id": "437318", "url": "https://www.iedb.org/epitope/437318" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "439834", "url": "https://www.iedb.org/epitope/439834" }, { "database": "IEDB", "id": "439836", "url": "https://www.iedb.org/epitope/439836" }, { "database": "IEDB", "id": "441072", "url": "https://www.iedb.org/epitope/441072" }, { "database": "IEDB", "id": "443759", "url": "https://www.iedb.org/epitope/443759" }, { "database": "IEDB", "id": "444312", "url": "https://www.iedb.org/epitope/444312" }, { "database": "IEDB", "id": "447449", "url": "https://www.iedb.org/epitope/447449" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "457112", "url": "https://www.iedb.org/epitope/457112" }, { "database": "IEDB", "id": "481713", "url": "https://www.iedb.org/epitope/481713" }, { "database": "IEDB", "id": "485565", "url": "https://www.iedb.org/epitope/485565" }, { "database": "IEDB", "id": "504446", "url": "https://www.iedb.org/epitope/504446" }, { "database": "IEDB", "id": "541918", "url": "https://www.iedb.org/epitope/541918" }, { "database": "IEDB", "id": "542799", "url": "https://www.iedb.org/epitope/542799" }, { "database": "IEDB", "id": "543334", "url": "https://www.iedb.org/epitope/543334" }, { "database": "IEDB", "id": "543716", "url": "https://www.iedb.org/epitope/543716" }, { "database": "IEDB", "id": "545696", "url": "https://www.iedb.org/epitope/545696" }, { "database": "IEDB", "id": "608131", "url": "https://www.iedb.org/epitope/608131" }, { "database": "IEDB", "id": "692247", "url": "https://www.iedb.org/epitope/692247" }, { "database": "IEDB", "id": "704794", "url": "https://www.iedb.org/epitope/704794" }, { "database": "IEDB", "id": "705809", "url": "https://www.iedb.org/epitope/705809" }, { "database": "IEDB", "id": "712009", "url": "https://www.iedb.org/epitope/712009" }, { "database": "IEDB", "id": "724573", "url": "https://www.iedb.org/epitope/724573" }, { "database": "IEDB", "id": "724675", "url": "https://www.iedb.org/epitope/724675" }, { "database": "IEDB", "id": "727008", "url": "https://www.iedb.org/epitope/727008" }, { "database": "IEDB", "id": "950426", "url": "https://www.iedb.org/epitope/950426" }, { "database": "IEDB", "id": "950966", "url": "https://www.iedb.org/epitope/950966" }, { "database": "IEDB", "id": "951665", "url": "https://www.iedb.org/epitope/951665" }, { "database": "IEDB", "id": "1000534", "url": "https://www.iedb.org/epitope/1000534" }, { "database": "IEDB", "id": "1000821", "url": "https://www.iedb.org/epitope/1000821" }, { "database": "IEDB", "id": "1010874", "url": "https://www.iedb.org/epitope/1010874" }, { "database": "IEDB", "id": "1020947", "url": "https://www.iedb.org/epitope/1020947" }, { "database": "IEDB", "id": "1061653", "url": "https://www.iedb.org/epitope/1061653" }, { "database": "IEDB", "id": "1061654", "url": "https://www.iedb.org/epitope/1061654" }, { "database": "IEDB", "id": "1086412", "url": "https://www.iedb.org/epitope/1086412" }, { "database": "IEDB", "id": "1088245", "url": "https://www.iedb.org/epitope/1088245" }, { "database": "IEDB", "id": "1324271", "url": "https://www.iedb.org/epitope/1324271" }, { "database": "IEDB", "id": "1325569", "url": "https://www.iedb.org/epitope/1325569" }, { "database": "IEDB", "id": "1348492", "url": "https://www.iedb.org/epitope/1348492" }, { "database": "IEDB", "id": "1362020", "url": "https://www.iedb.org/epitope/1362020" }, { "database": "IEDB", "id": "1363574", "url": "https://www.iedb.org/epitope/1363574" }, { "database": "IEDB", "id": "1368512", "url": "https://www.iedb.org/epitope/1368512" }, { "database": "IEDB", "id": "1875219", "url": "https://www.iedb.org/epitope/1875219" }, { "database": "IEDB", "id": "1903123", "url": "https://www.iedb.org/epitope/1903123" }, { "database": "IEDB", "id": "1903950", "url": "https://www.iedb.org/epitope/1903950" }, { "database": "IEDB", "id": "1973173", "url": "https://www.iedb.org/epitope/1973173" }, { "database": "IEDB", "id": "1973284", "url": "https://www.iedb.org/epitope/1973284" }, { "database": "IEDB", "id": "1974189", "url": "https://www.iedb.org/epitope/1974189" }, { "database": "IEDB", "id": "1975908", "url": "https://www.iedb.org/epitope/1975908" }, { "database": "IEDB", "id": "1975944", "url": "https://www.iedb.org/epitope/1975944" }, { "database": "IEDB", "id": "1978672", "url": "https://www.iedb.org/epitope/1978672" }, { "database": "IEDB", "id": "1980727", "url": "https://www.iedb.org/epitope/1980727" }, { "database": "IEDB", "id": "1980736", "url": "https://www.iedb.org/epitope/1980736" }, { "database": "IEDB", "id": "1981265", "url": "https://www.iedb.org/epitope/1981265" }, { "database": "IEDB", "id": "1982013", "url": "https://www.iedb.org/epitope/1982013" }, { "database": "IEDB", "id": "1982592", "url": "https://www.iedb.org/epitope/1982592" }, { "database": "IEDB", "id": "1982662", "url": "https://www.iedb.org/epitope/1982662" }, { "database": "IEDB", "id": "1982747", "url": "https://www.iedb.org/epitope/1982747" }, { "database": "IEDB", "id": "1983090", "url": "https://www.iedb.org/epitope/1983090" }, { "database": "IEDB", "id": "1983816", "url": "https://www.iedb.org/epitope/1983816" }, { "database": "IEDB", "id": "1983820", "url": "https://www.iedb.org/epitope/1983820" }, { "database": "IEDB", "id": "1983968", "url": "https://www.iedb.org/epitope/1983968" }, { "database": "IEDB", "id": "1984238", "url": "https://www.iedb.org/epitope/1984238" }, { "database": "IEDB", "id": "1984761", "url": "https://www.iedb.org/epitope/1984761" }, { "database": "IEDB", "id": "1984899", "url": "https://www.iedb.org/epitope/1984899" }, { "database": "IEDB", "id": "1985523", "url": "https://www.iedb.org/epitope/1985523" }, { "database": "IEDB", "id": "1985781", "url": "https://www.iedb.org/epitope/1985781" }, { "database": "IEDB", "id": "1985844", "url": "https://www.iedb.org/epitope/1985844" }, { "database": "IEDB", "id": "1987049", "url": "https://www.iedb.org/epitope/1987049" }, { "database": "IEDB", "id": "1988190", "url": "https://www.iedb.org/epitope/1988190" }, { "database": "IEDB", "id": "1988316", "url": "https://www.iedb.org/epitope/1988316" }, { "database": "IEDB", "id": "1988317", "url": "https://www.iedb.org/epitope/1988317" }, { "database": "IEDB", "id": "1988479", "url": "https://www.iedb.org/epitope/1988479" }, { "database": "IEDB", "id": "1990952", "url": "https://www.iedb.org/epitope/1990952" }, { "database": "IEDB", "id": "1992014", "url": "https://www.iedb.org/epitope/1992014" }, { "database": "IEDB", "id": "1993917", "url": "https://www.iedb.org/epitope/1993917" }, { "database": "IEDB", "id": "1995094", "url": "https://www.iedb.org/epitope/1995094" }, { "database": "IEDB", "id": "1997223", "url": "https://www.iedb.org/epitope/1997223" }, { "database": "IEDB", "id": "1997487", "url": "https://www.iedb.org/epitope/1997487" }, { "database": "IEDB", "id": "1998946", "url": "https://www.iedb.org/epitope/1998946" }, { "database": "IEDB", "id": "1999388", "url": "https://www.iedb.org/epitope/1999388" }, { "database": "IEDB", "id": "1999391", "url": "https://www.iedb.org/epitope/1999391" } ], "reference": [ { "type": "PubMed", "id": "32938616", "url": "https://glygen.org/publication/PubMed/32938616" } ] }, { "title": "Biogenesis of HLA Ligand Presentation in Immune Cells Upon Activation Reveals Changes in Peptide Length Preference.", "journal": "Frontiers in immunology", "date": "2020", "authors": "Marino Fabio, Semilietof Aikaterini, Michaux Justine, Pak Hui-Song, Coukos George, M\u00fcller Markus, Bassani-Sternberg Michal", "evidence": [ { "database": "IEDB", "id": "224160", "url": "https://www.iedb.org/epitope/224160" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "443759", "url": "https://www.iedb.org/epitope/443759" }, { "database": "IEDB", "id": "446446", "url": "https://www.iedb.org/epitope/446446" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "509357", "url": "https://www.iedb.org/epitope/509357" }, { "database": "IEDB", "id": "577760", "url": "https://www.iedb.org/epitope/577760" }, { "database": "IEDB", "id": "578286", "url": "https://www.iedb.org/epitope/578286" }, { "database": "IEDB", "id": "583773", "url": "https://www.iedb.org/epitope/583773" }, { "database": "IEDB", "id": "612254", "url": "https://www.iedb.org/epitope/612254" }, { "database": "IEDB", "id": "651868", "url": "https://www.iedb.org/epitope/651868" }, { "database": "IEDB", "id": "772977", "url": "https://www.iedb.org/epitope/772977" }, { "database": "IEDB", "id": "947914", "url": "https://www.iedb.org/epitope/947914" }, { "database": "IEDB", "id": "950518", "url": "https://www.iedb.org/epitope/950518" }, { "database": "IEDB", "id": "1865259", "url": "https://www.iedb.org/epitope/1865259" }, { "database": "IEDB", "id": "1865515", "url": "https://www.iedb.org/epitope/1865515" }, { "database": "IEDB", "id": "1866967", "url": "https://www.iedb.org/epitope/1866967" }, { "database": "IEDB", "id": "1868443", "url": "https://www.iedb.org/epitope/1868443" }, { "database": "IEDB", "id": "1869127", "url": "https://www.iedb.org/epitope/1869127" } ], "reference": [ { "type": "PubMed", "id": "32983136", "url": "https://glygen.org/publication/PubMed/32983136" } ] }, { "title": "HLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis.", "journal": "Cell", "date": "2020-11-25", "authors": "Wang Jian, Jelcic Ivan, M\u00fchlenbruch Lena, Haunerdinger Veronika, Toussaint Nora C, Zhao Yingdong, Cruciani Carolina, Faigle Wolfgang, Naghavian Reza, Foege Magdalena, Binder Thomas M C, Eiermann Thomas, Opitz Lennart, Fuentes-Font Laura, Reynolds Richard, Kwok William W, Nguyen Julie T, Lee Jar-How, Lutterotti Andreas, M\u00fcnz Christian, Rammensee Hans-Georg, Hauri-Hohl Mathias, Sospedra Mireia, Stevanovic Stefan, Martin Roland", "evidence": [ { "database": "IEDB", "id": "426187", "url": "https://www.iedb.org/epitope/426187" }, { "database": "IEDB", "id": "1393623", "url": "https://www.iedb.org/epitope/1393623" } ], "reference": [ { "type": "PubMed", "id": "33091337", "url": "https://glygen.org/publication/PubMed/33091337" } ] }, { "title": "Mild Acid Elution and MHC Immunoaffinity Chromatography Reveal Similar Albeit Not Identical Profiles of the HLA Class I Immunopeptidome.", "journal": "Journal of proteome research", "date": "2021-01-01", "authors": "Sturm Theo, Sautter Benedikt, W\u00f6rner Tobias P, Stevanovi\u0107 Stefan, Rammensee Hans-Georg, Planz Oliver, Heck Albert J R, Aebersold Ruedi", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "441072", "url": "https://www.iedb.org/epitope/441072" }, { "database": "IEDB", "id": "447449", "url": "https://www.iedb.org/epitope/447449" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" } ], "reference": [ { "type": "PubMed", "id": "33141586", "url": "https://glygen.org/publication/PubMed/33141586" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q5T4S7", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q5T4S7" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "Thermostability profiling of MHC-bound peptides: a new dimension in immunopeptidomics and aid for immunotherapy design.", "journal": "Nature communications", "date": "2020-12-09", "authors": "Jappe Emma C, Garde Christian, Ramarathinam Sri H, Passantino Ethan, Illing Patricia T, Mifsud Nicole A, Trolle Thomas, Kringelum Jens V, Croft Nathan P, Purcell Anthony W", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "437318", "url": "https://www.iedb.org/epitope/437318" }, { "database": "IEDB", "id": "441072", "url": "https://www.iedb.org/epitope/441072" }, { "database": "IEDB", "id": "444312", "url": "https://www.iedb.org/epitope/444312" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "459480", "url": "https://www.iedb.org/epitope/459480" }, { "database": "IEDB", "id": "459761", "url": "https://www.iedb.org/epitope/459761" }, { "database": "IEDB", "id": "466305", "url": "https://www.iedb.org/epitope/466305" }, { "database": "IEDB", "id": "479903", "url": "https://www.iedb.org/epitope/479903" }, { "database": "IEDB", "id": "486318", "url": "https://www.iedb.org/epitope/486318" }, { "database": "IEDB", "id": "504446", "url": "https://www.iedb.org/epitope/504446" }, { "database": "IEDB", "id": "545696", "url": "https://www.iedb.org/epitope/545696" }, { "database": "IEDB", "id": "577812", "url": "https://www.iedb.org/epitope/577812" }, { "database": "IEDB", "id": "692247", "url": "https://www.iedb.org/epitope/692247" }, { "database": "IEDB", "id": "707990", "url": "https://www.iedb.org/epitope/707990" }, { "database": "IEDB", "id": "1000534", "url": "https://www.iedb.org/epitope/1000534" }, { "database": "IEDB", "id": "1020947", "url": "https://www.iedb.org/epitope/1020947" }, { "database": "IEDB", "id": "1037463", "url": "https://www.iedb.org/epitope/1037463" }, { "database": "IEDB", "id": "1061654", "url": "https://www.iedb.org/epitope/1061654" }, { "database": "IEDB", "id": "1287579", "url": "https://www.iedb.org/epitope/1287579" }, { "database": "IEDB", "id": "1316662", "url": "https://www.iedb.org/epitope/1316662" }, { "database": "IEDB", "id": "1317891", "url": "https://www.iedb.org/epitope/1317891" }, { "database": "IEDB", "id": "1325569", "url": "https://www.iedb.org/epitope/1325569" }, { "database": "IEDB", "id": "1349469", "url": "https://www.iedb.org/epitope/1349469" }, { "database": "IEDB", "id": "1353927", "url": "https://www.iedb.org/epitope/1353927" } ], "reference": [ { "type": "PubMed", "id": "33298915", "url": "https://glygen.org/publication/PubMed/33298915" } ] }, { "title": "The Impact of Biomaterial Cell Contact on the Immunopeptidome.", "journal": "Frontiers in bioengineering and biotechnology", "date": "2020", "authors": "Ghosh Michael, Hartmann Hanna, Jakobi Meike, M\u00e4rz L\u00e9o, Bichmann Leon, Freudenmann Lena K, M\u00fchlenbruch Lena, Segan S\u00f6ren, Rammensee Hans-Georg, Schneiderhan-Marra Nicole, Shipp Christopher, Stevanovi\u0107 Stefan, Joos Thomas O", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "469366", "url": "https://www.iedb.org/epitope/469366" }, { "database": "IEDB", "id": "955028", "url": "https://www.iedb.org/epitope/955028" } ], "reference": [ { "type": "PubMed", "id": "33392160", "url": "https://glygen.org/publication/PubMed/33392160" } ] }, { "title": "CIITA-Transduced Glioblastoma Cells Uncover a Rich Repertoire of Clinically Relevant Tumor-Associated HLA-II Antigens.", "journal": "Molecular & cellular proteomics : MCP", "date": "2021", "authors": "Forlani Greta, Michaux Justine, Pak HuiSong, Huber Florian, Marie Joseph Elodie Lauret, Ramia Elise, Stevenson Brian J, Linnebacher Michael, Accolla Roberto S, Bassani-Sternberg Michal", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "224160", "url": "https://www.iedb.org/epitope/224160" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "443759", "url": "https://www.iedb.org/epitope/443759" }, { "database": "IEDB", "id": "446446", "url": "https://www.iedb.org/epitope/446446" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "486924", "url": "https://www.iedb.org/epitope/486924" }, { "database": "IEDB", "id": "505055", "url": "https://www.iedb.org/epitope/505055" }, { "database": "IEDB", "id": "542799", "url": "https://www.iedb.org/epitope/542799" }, { "database": "IEDB", "id": "578286", "url": "https://www.iedb.org/epitope/578286" }, { "database": "IEDB", "id": "583773", "url": "https://www.iedb.org/epitope/583773" }, { "database": "IEDB", "id": "607787", "url": "https://www.iedb.org/epitope/607787" }, { "database": "IEDB", "id": "947914", "url": "https://www.iedb.org/epitope/947914" }, { "database": "IEDB", "id": "1045035", "url": "https://www.iedb.org/epitope/1045035" }, { "database": "IEDB", "id": "1599370", "url": "https://www.iedb.org/epitope/1599370" }, { "database": "IEDB", "id": "1603594", "url": "https://www.iedb.org/epitope/1603594" }, { "database": "IEDB", "id": "1614639", "url": "https://www.iedb.org/epitope/1614639" }, { "database": "IEDB", "id": "1621026", "url": "https://www.iedb.org/epitope/1621026" } ], "reference": [ { "type": "PubMed", "id": "33592498", "url": "https://glygen.org/publication/PubMed/33592498" } ] }, { "title": "Alterations in the HLA-B*57:01 Immunopeptidome by Flucloxacillin and Immunogenicity of Drug-Haptenated Peptides.", "journal": "Frontiers in immunology", "date": "2020", "authors": "Puig Montserrat, Ananthula Suryatheja, Venna Ramesh, Kumar Polumuri Swamy, Mattson Elliot, Walker Lacey M, Cardone Marco, Takahashi Mayumi, Su Shan, Boyd Lisa F, Natarajan Kannan, Abdoulaeva Galina, Wu Wells W, Roderiquez Gregory, Hildebrand William H, Beaucage Serge L, Li Zhihua, Margulies David H, Norcross Michael A", "evidence": [ { "database": "IEDB", "id": "175897", "url": "https://www.iedb.org/epitope/175897" }, { "database": "IEDB", "id": "620554", "url": "https://www.iedb.org/epitope/620554" }, { "database": "IEDB", "id": "1780680", "url": "https://www.iedb.org/epitope/1780680" }, { "database": "IEDB", "id": "1836408", "url": "https://www.iedb.org/epitope/1836408" } ], "reference": [ { "type": "PubMed", "id": "33633747", "url": "https://glygen.org/publication/PubMed/33633747" } ] }, { "title": "Most non-canonical proteins uniquely populate the proteome or immunopeptidome.", "journal": "Cell reports", "date": "2021-03-09", "authors": "Ruiz Cuevas Maria Virginia, Hardy Marie-Pierre, Holl\u00fd Jaroslav, Bonneil \u00c9ric, Durette Chantal, Courcelles Mathieu, Lanoix Jo\u00ebl, C\u00f4t\u00e9 Caroline, Staudt Louis M, Lemieux S\u00e9bastien, Thibault Pierre, Perreault Claude, Yewdell Jonathan W", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "446446", "url": "https://www.iedb.org/epitope/446446" }, { "database": "IEDB", "id": "479903", "url": "https://www.iedb.org/epitope/479903" }, { "database": "IEDB", "id": "509357", "url": "https://www.iedb.org/epitope/509357" }, { "database": "IEDB", "id": "548318", "url": "https://www.iedb.org/epitope/548318" }, { "database": "IEDB", "id": "1081394", "url": "https://www.iedb.org/epitope/1081394" }, { "database": "IEDB", "id": "1324271", "url": "https://www.iedb.org/epitope/1324271" }, { "database": "IEDB", "id": "1638735", "url": "https://www.iedb.org/epitope/1638735" } ], "reference": [ { "type": "PubMed", "id": "33691108", "url": "https://glygen.org/publication/PubMed/33691108" } ] }, { "title": "ERAP2 Increases the Abundance of a Peptide Submotif Highly Selective for the Birdshot Uveitis-Associated HLA-A29.", "journal": "Frontiers in immunology", "date": "2021", "authors": "Venema Wouter J, Hiddingh Sanne, de Boer Joke H, Claas Frans H J, Mulder Arend, den Hollander Anneke I, Stratikos Efstratios, Sarkizova Siranush, van der Veken Lars T, Janssen George M C, van Veelen Peter A, Kuiper Jonas J W", "evidence": [ { "database": "IEDB", "id": "426187", "url": "https://www.iedb.org/epitope/426187" }, { "database": "IEDB", "id": "427253", "url": "https://www.iedb.org/epitope/427253" }, { "database": "IEDB", "id": "443759", "url": "https://www.iedb.org/epitope/443759" }, { "database": "IEDB", "id": "485565", "url": "https://www.iedb.org/epitope/485565" }, { "database": "IEDB", "id": "630184", "url": "https://www.iedb.org/epitope/630184" }, { "database": "IEDB", "id": "724675", "url": "https://www.iedb.org/epitope/724675" } ], "reference": [ { "type": "PubMed", "id": "33717175", "url": "https://glygen.org/publication/PubMed/33717175" } ] }, { "title": "Carbamazepine Induces Focused T Cell Responses in Resolved Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Cases But Does Not Perturb the Immunopeptidome for T Cell Recognition.", "journal": "Frontiers in immunology", "date": "2021", "authors": "Mifsud Nicole A, Illing Patricia T, Lai Jeffrey W, Fettke Heidi, Hensen Luca, Huang Ziyi, Rossjohn Jamie, Vivian Julian P, Kwan Patrick, Purcell Anthony W", "evidence": [ { "database": "IEDB", "id": "425406", "url": "https://www.iedb.org/epitope/425406" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "577760", "url": "https://www.iedb.org/epitope/577760" }, { "database": "IEDB", "id": "642791", "url": "https://www.iedb.org/epitope/642791" }, { "database": "IEDB", "id": "692247", "url": "https://www.iedb.org/epitope/692247" }, { "database": "IEDB", "id": "704794", "url": "https://www.iedb.org/epitope/704794" }, { "database": "IEDB", "id": "892512", "url": "https://www.iedb.org/epitope/892512" }, { "database": "IEDB", "id": "902886", "url": "https://www.iedb.org/epitope/902886" }, { "database": "IEDB", "id": "1283973", "url": "https://www.iedb.org/epitope/1283973" }, { "database": "IEDB", "id": "1317891", "url": "https://www.iedb.org/epitope/1317891" }, { "database": "IEDB", "id": "1563157", "url": "https://www.iedb.org/epitope/1563157" }, { "database": "IEDB", "id": "1563472", "url": "https://www.iedb.org/epitope/1563472" }, { "database": "IEDB", "id": "1567457", "url": "https://www.iedb.org/epitope/1567457" }, { "database": "IEDB", "id": "1570383", "url": "https://www.iedb.org/epitope/1570383" }, { "database": "IEDB", "id": "1571127", "url": "https://www.iedb.org/epitope/1571127" }, { "database": "IEDB", "id": "1572602", "url": "https://www.iedb.org/epitope/1572602" }, { "database": "IEDB", "id": "1573966", "url": "https://www.iedb.org/epitope/1573966" }, { "database": "IEDB", "id": "1593603", "url": "https://www.iedb.org/epitope/1593603" } ], "reference": [ { "type": "PubMed", "id": "33912179", "url": "https://glygen.org/publication/PubMed/33912179" } ] }, { "title": "An Integrated Genomic, Proteomic, and Immunopeptidomic Approach to Discover Treatment-Induced Neoantigens.", "journal": "Frontiers in immunology", "date": "2021", "authors": "Olsson Niclas, Heberling Marlene L, Zhang Lichao, Jhunjhunwala Suchit, Phung Qui T, Lin Sarah, Anania Veronica G, Lill Jennie R, Elias Joshua E", "evidence": [ { "database": "IEDB", "id": "162846", "url": "https://www.iedb.org/epitope/162846" }, { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "437318", "url": "https://www.iedb.org/epitope/437318" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "1585446", "url": "https://www.iedb.org/epitope/1585446" }, { "database": "IEDB", "id": "1586054", "url": "https://www.iedb.org/epitope/1586054" }, { "database": "IEDB", "id": "1589028", "url": "https://www.iedb.org/epitope/1589028" } ], "reference": [ { "type": "PubMed", "id": "33936100", "url": "https://glygen.org/publication/PubMed/33936100" } ] }, { "title": "IFN\u03b3 Modulates the Immunopeptidome of Triple Negative Breast Cancer Cells by Enhancing and Diversifying Antigen Processing and Presentation.", "journal": "Frontiers in immunology", "date": "2021", "authors": "Goncalves Gabriel, Mullan Kerry A, Duscharla Divya, Ayala Rochelle, Croft Nathan P, Faridi Pouya, Purcell Anthony W", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "224160", "url": "https://www.iedb.org/epitope/224160" }, { "database": "IEDB", "id": "437318", "url": "https://www.iedb.org/epitope/437318" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "441072", "url": "https://www.iedb.org/epitope/441072" }, { "database": "IEDB", "id": "443759", "url": "https://www.iedb.org/epitope/443759" }, { "database": "IEDB", "id": "444312", "url": "https://www.iedb.org/epitope/444312" }, { "database": "IEDB", "id": "447449", "url": "https://www.iedb.org/epitope/447449" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "464922", "url": "https://www.iedb.org/epitope/464922" }, { "database": "IEDB", "id": "471688", "url": "https://www.iedb.org/epitope/471688" }, { "database": "IEDB", "id": "504446", "url": "https://www.iedb.org/epitope/504446" }, { "database": "IEDB", "id": "542799", "url": "https://www.iedb.org/epitope/542799" }, { "database": "IEDB", "id": "545530", "url": "https://www.iedb.org/epitope/545530" }, { "database": "IEDB", "id": "583773", "url": "https://www.iedb.org/epitope/583773" }, { "database": "IEDB", "id": "607787", "url": "https://www.iedb.org/epitope/607787" }, { "database": "IEDB", "id": "608036", "url": "https://www.iedb.org/epitope/608036" }, { "database": "IEDB", "id": "608661", "url": "https://www.iedb.org/epitope/608661" }, { "database": "IEDB", "id": "612254", "url": "https://www.iedb.org/epitope/612254" }, { "database": "IEDB", "id": "634481", "url": "https://www.iedb.org/epitope/634481" }, { "database": "IEDB", "id": "707990", "url": "https://www.iedb.org/epitope/707990" }, { "database": "IEDB", "id": "718575", "url": "https://www.iedb.org/epitope/718575" }, { "database": "IEDB", "id": "724680", "url": "https://www.iedb.org/epitope/724680" }, { "database": "IEDB", "id": "947914", "url": "https://www.iedb.org/epitope/947914" }, { "database": "IEDB", "id": "950518", "url": "https://www.iedb.org/epitope/950518" }, { "database": "IEDB", "id": "950966", "url": "https://www.iedb.org/epitope/950966" }, { "database": "IEDB", "id": "1000821", "url": "https://www.iedb.org/epitope/1000821" }, { "database": "IEDB", "id": "1020947", "url": "https://www.iedb.org/epitope/1020947" }, { "database": "IEDB", "id": "1061653", "url": "https://www.iedb.org/epitope/1061653" }, { "database": "IEDB", "id": "1083641", "url": "https://www.iedb.org/epitope/1083641" }, { "database": "IEDB", "id": "1168155", "url": "https://www.iedb.org/epitope/1168155" }, { "database": "IEDB", "id": "1168156", "url": "https://www.iedb.org/epitope/1168156" }, { "database": "IEDB", "id": "1226861", "url": "https://www.iedb.org/epitope/1226861" }, { "database": "IEDB", "id": "1351755", "url": "https://www.iedb.org/epitope/1351755" }, { "database": "IEDB", "id": "1368512", "url": "https://www.iedb.org/epitope/1368512" }, { "database": "IEDB", "id": "1563157", "url": "https://www.iedb.org/epitope/1563157" }, { "database": "IEDB", "id": "1585446", "url": "https://www.iedb.org/epitope/1585446" }, { "database": "IEDB", "id": "1866967", "url": "https://www.iedb.org/epitope/1866967" }, { "database": "IEDB", "id": "1868443", "url": "https://www.iedb.org/epitope/1868443" }, { "database": "IEDB", "id": "1875218", "url": "https://www.iedb.org/epitope/1875218" }, { "database": "IEDB", "id": "1875219", "url": "https://www.iedb.org/epitope/1875219" }, { "database": "IEDB", "id": "1879356", "url": "https://www.iedb.org/epitope/1879356" }, { "database": "IEDB", "id": "1889152", "url": "https://www.iedb.org/epitope/1889152" }, { "database": "IEDB", "id": "1896431", "url": "https://www.iedb.org/epitope/1896431" }, { "database": "IEDB", "id": "1903123", "url": "https://www.iedb.org/epitope/1903123" }, { "database": "IEDB", "id": "1903355", "url": "https://www.iedb.org/epitope/1903355" }, { "database": "IEDB", "id": "1903950", "url": "https://www.iedb.org/epitope/1903950" }, { "database": "IEDB", "id": "1906669", "url": "https://www.iedb.org/epitope/1906669" }, { "database": "IEDB", "id": "1907824", "url": "https://www.iedb.org/epitope/1907824" }, { "database": "IEDB", "id": "1910179", "url": "https://www.iedb.org/epitope/1910179" }, { "database": "IEDB", "id": "1911547", "url": "https://www.iedb.org/epitope/1911547" }, { "database": "IEDB", "id": "1914944", "url": "https://www.iedb.org/epitope/1914944" }, { "database": "IEDB", "id": "1917541", "url": "https://www.iedb.org/epitope/1917541" }, { "database": "IEDB", "id": "1919320", "url": "https://www.iedb.org/epitope/1919320" }, { "database": "IEDB", "id": "1920647", "url": "https://www.iedb.org/epitope/1920647" }, { "database": "IEDB", "id": "1921992", "url": "https://www.iedb.org/epitope/1921992" }, { "database": "IEDB", "id": "1926476", "url": "https://www.iedb.org/epitope/1926476" }, { "database": "IEDB", "id": "1928199", "url": "https://www.iedb.org/epitope/1928199" }, { "database": "IEDB", "id": "1928954", "url": "https://www.iedb.org/epitope/1928954" }, { "database": "IEDB", "id": "1930098", "url": "https://www.iedb.org/epitope/1930098" }, { "database": "IEDB", "id": "1938990", "url": "https://www.iedb.org/epitope/1938990" }, { "database": "IEDB", "id": "1942549", "url": "https://www.iedb.org/epitope/1942549" } ], "reference": [ { "type": "PubMed", "id": "33968037", "url": "https://glygen.org/publication/PubMed/33968037" } ] }, { "title": "NMD inhibition by 5-azacytidine augments presentation of immunogenic frameshift-derived neoepitopes.", "journal": "iScience", "date": "2021-04-23", "authors": "Becker Jonas P, Helm Dominic, Rettel Mandy, Stein Frank, Hernandez-Sanchez Alejandro, Urban Katharina, Gebert Johannes, Kloor Matthias, Neu-Yilik Gabriele, von Knebel Doeberitz Magnus, Hentze Matthias W, Kulozik Andreas E", "evidence": [ { "database": "IEDB", "id": "431157", "url": "https://www.iedb.org/epitope/431157" }, { "database": "IEDB", "id": "441072", "url": "https://www.iedb.org/epitope/441072" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "471688", "url": "https://www.iedb.org/epitope/471688" }, { "database": "IEDB", "id": "575460", "url": "https://www.iedb.org/epitope/575460" }, { "database": "IEDB", "id": "866511", "url": "https://www.iedb.org/epitope/866511" } ], "reference": [ { "type": "PubMed", "id": "33981976", "url": "https://glygen.org/publication/PubMed/33981976" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q5T4S7", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q5T4S7" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "The Effect of Interferons on Presentation of Defective Ribosomal Products as HLA Peptides.", "journal": "Molecular & cellular proteomics : MCP", "date": "2021", "authors": "Komov Liran, Melamed Kadosh Dganit, Barnea Eilon, Admon Arie", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "471688", "url": "https://www.iedb.org/epitope/471688" }, { "database": "IEDB", "id": "541918", "url": "https://www.iedb.org/epitope/541918" }, { "database": "IEDB", "id": "727008", "url": "https://www.iedb.org/epitope/727008" } ], "reference": [ { "type": "PubMed", "id": "34087483", "url": "https://glygen.org/publication/PubMed/34087483" } ] }, { "title": "Profiling SARS-CoV-2 HLA-I peptidome reveals T\u00a0cell epitopes from out-of-frame ORFs.", "journal": "Cell", "date": "2021-07-22", "authors": "Weingarten-Gabbay Shira, Klaeger Susan, Sarkizova Siranush, Pearlman Leah R, Chen Da-Yuan, Gallagher Kathleen M E, Bauer Matthew R, Taylor Hannah B, Dunn W Augustine, Tarr Christina, Sidney John, Rachimi Suzanna, Conway Hasahn L, Katsis Katelin, Wang Yuntong, Leistritz-Edwards Del, Durkin Melissa R, Tomkins-Tinch Christopher H, Finkel Yaara, Nachshon Aharon, Gentili Matteo, Rivera Keith D, Carulli Isabel P, Chea Vipheaviny A, Chandrashekar Abishek, Bozkus Cansu Cimen, Carrington Mary, , Bhardwaj Nina, Barouch Dan H, Sette Alessandro, Maus Marcela V, Rice Charles M, Clauser Karl R, Keskin Derin B, Pregibon Daniel C, Hacohen Nir, Carr Steven A, Abelin Jennifer G, Saeed Mohsan, Sabeti Pardis C", "evidence": [ { "database": "IEDB", "id": "441072", "url": "https://www.iedb.org/epitope/441072" }, { "database": "IEDB", "id": "471688", "url": "https://www.iedb.org/epitope/471688" }, { "database": "IEDB", "id": "542799", "url": "https://www.iedb.org/epitope/542799" }, { "database": "IEDB", "id": "575387", "url": "https://www.iedb.org/epitope/575387" }, { "database": "IEDB", "id": "731467", "url": "https://www.iedb.org/epitope/731467" }, { "database": "IEDB", "id": "953609", "url": "https://www.iedb.org/epitope/953609" }, { "database": "IEDB", "id": "953668", "url": "https://www.iedb.org/epitope/953668" }, { "database": "IEDB", "id": "953763", "url": "https://www.iedb.org/epitope/953763" }, { "database": "IEDB", "id": "1000534", "url": "https://www.iedb.org/epitope/1000534" }, { "database": "IEDB", "id": "1059190", "url": "https://www.iedb.org/epitope/1059190" }, { "database": "IEDB", "id": "1324271", "url": "https://www.iedb.org/epitope/1324271" }, { "database": "IEDB", "id": "1333937", "url": "https://www.iedb.org/epitope/1333937" }, { "database": "IEDB", "id": "1625641", "url": "https://www.iedb.org/epitope/1625641" } ], "reference": [ { "type": "PubMed", "id": "34171305", "url": "https://glygen.org/publication/PubMed/34171305" } ] }, { "title": "Proteogenomic identification of an immunogenic HLA class I neoantigen in mismatch repair-deficient colorectal cancer tissue.", "journal": "JCI insight", "date": "2021-07-22", "authors": "Hirama Tomomi, Tokita Serina, Nakatsugawa Munehide, Murata Kenji, Nannya Yasuhito, Matsuo Kazuhiko, Inoko Hidetoshi, Hirohashi Yoshihiko, Hashimoto Shinichi, Ogawa Seishi, Takemasa Ichiro, Sato Noriyuki, Hata Fumitake, Kanaseki Takayuki, Torigoe Toshihiko", "evidence": [ { "database": "IEDB", "id": "469366", "url": "https://www.iedb.org/epitope/469366" } ], "reference": [ { "type": "PubMed", "id": "34185709", "url": "https://glygen.org/publication/PubMed/34185709" } ] }, { "title": "HLA-B and cysteinylated ligands distinguish the antigen presentation landscape of extracellular vesicles.", "journal": "Communications biology", "date": "2021-07-01", "authors": "Bauz\u00e1-Martinez Julia, Heck Albert J R, Wu Wei", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "543334", "url": "https://www.iedb.org/epitope/543334" } ], "reference": [ { "type": "PubMed", "id": "34211107", "url": "https://glygen.org/publication/PubMed/34211107" } ] }, { "title": "Synthesis of Na2S2O4 mediated cleavable affinity tag for labeling of O-GlcNAc modified proteins via azide-alkyne cycloaddition.", "journal": "Bioorganic & medicinal chemistry letters", "date": "2021", "authors": "Wang J, Dou B, Zheng L, Cao W, Zeng X, Wen Y, Ma J, Li X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q5T4S7", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q5T4S7" } ], "reference": [ { "type": "PubMed", "id": "34229054", "url": "https://glygen.org/publication/PubMed/34229054" } ] }, { "title": "HLA class II immunopeptidomics reveals that co-inherited HLA-allotypes within an extended haplotype can improve proteome coverage for immunosurveillance.", "journal": "Proteomics", "date": "2021-09", "authors": "Ramarathinam Sri H, Ho Bosco K, Dudek Nadine L, Purcell Anthony W", "evidence": [ { "database": "IEDB", "id": "1716581", "url": "https://www.iedb.org/epitope/1716581" }, { "database": "IEDB", "id": "1722547", "url": "https://www.iedb.org/epitope/1722547" } ], "reference": [ { "type": "PubMed", "id": "34357683", "url": "https://glygen.org/publication/PubMed/34357683" } ] }, { "title": "GRIK2 is a target for bladder cancer stem-like cell-targeting immunotherapy.", "journal": "Cancer immunology, immunotherapy : CII", "date": "2022-04", "authors": "Miyata Haruka, Hirohashi Yoshihiko, Yamada Shuhei, Yanagawa Junko, Murai Aiko, Hashimoto Shinichi, Tokita Serina, Hori Kanta, Abe Takashige, Kubo Terufumi, Tsukahara Tomohide, Kanaseki Takayuki, Shinohara Nobuo, Torigoe Toshihiko", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "504446", "url": "https://www.iedb.org/epitope/504446" } ], "reference": [ { "type": "PubMed", "id": "34405274", "url": "https://glygen.org/publication/PubMed/34405274" } ] }, { "title": "Immunopeptidogenomics: Harnessing RNA-Seq to Illuminate the Dark Immunopeptidome.", "journal": "Molecular & cellular proteomics : MCP", "date": "2021", "authors": "Scull Katherine E, Pandey Kirti, Ramarathinam Sri H, Purcell Anthony W", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "437318", "url": "https://www.iedb.org/epitope/437318" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "441072", "url": "https://www.iedb.org/epitope/441072" }, { "database": "IEDB", "id": "444312", "url": "https://www.iedb.org/epitope/444312" }, { "database": "IEDB", "id": "447449", "url": "https://www.iedb.org/epitope/447449" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "471688", "url": "https://www.iedb.org/epitope/471688" }, { "database": "IEDB", "id": "504446", "url": "https://www.iedb.org/epitope/504446" }, { "database": "IEDB", "id": "542799", "url": "https://www.iedb.org/epitope/542799" }, { "database": "IEDB", "id": "892512", "url": "https://www.iedb.org/epitope/892512" }, { "database": "IEDB", "id": "1015859", "url": "https://www.iedb.org/epitope/1015859" }, { "database": "IEDB", "id": "1020947", "url": "https://www.iedb.org/epitope/1020947" }, { "database": "IEDB", "id": "1061653", "url": "https://www.iedb.org/epitope/1061653" }, { "database": "IEDB", "id": "1348492", "url": "https://www.iedb.org/epitope/1348492" }, { "database": "IEDB", "id": "1351755", "url": "https://www.iedb.org/epitope/1351755" }, { "database": "IEDB", "id": "1361696", "url": "https://www.iedb.org/epitope/1361696" }, { "database": "IEDB", "id": "1362020", "url": "https://www.iedb.org/epitope/1362020" }, { "database": "IEDB", "id": "1363574", "url": "https://www.iedb.org/epitope/1363574" }, { "database": "IEDB", "id": "1368512", "url": "https://www.iedb.org/epitope/1368512" }, { "database": "IEDB", "id": "1373066", "url": "https://www.iedb.org/epitope/1373066" }, { "database": "IEDB", "id": "1376237", "url": "https://www.iedb.org/epitope/1376237" }, { "database": "IEDB", "id": "1852536", "url": "https://www.iedb.org/epitope/1852536" } ], "reference": [ { "type": "PubMed", "id": "34509645", "url": "https://glygen.org/publication/PubMed/34509645" } ] }, { "title": "Characterization of HLA-A*33:03 epitopes via immunoprecipitation and LC-MS/MS.", "journal": "Proteomics", "date": "2022", "authors": "Khan A, Shin JY, So MK, Na JH, Justesen S, Ansari AA, Ko BJ, Ahn SM", "evidence": [ { "database": "IEDB", "id": "1712555", "url": "https://www.iedb.org/epitope/1712555" }, { "database": "IEDB", "id": "1713240", "url": "https://www.iedb.org/epitope/1713240" }, { "database": "IEDB", "id": "1714464", "url": "https://www.iedb.org/epitope/1714464" }, { "database": "IEDB", "id": "1714650", "url": "https://www.iedb.org/epitope/1714650" } ], "reference": [ { "type": "PubMed", "id": "34561969", "url": "https://glygen.org/publication/PubMed/34561969" } ] }, { "title": "Truncation of the TPR domain of OGT alters substrate and glycosite selection.", "journal": "Analytical and bioanalytical chemistry", "date": "2021", "authors": "Ramirez DH, Yang B, D'Souza AK, Shen D, Woo CM", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q5T4S7", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q5T4S7" } ], "reference": [ { "type": "PubMed", "id": "34725712", "url": "https://glygen.org/publication/PubMed/34725712" } ] }, { "title": "The N-terminal cysteine is a dual sensor of oxygen and oxidative stress.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2021-12-14", "authors": "Heo Ah Jung, Kim Su Bin, Ji Chang Hoon, Han Dohyun, Lee Su Jin, Lee Su Hyun, Lee Min Ju, Lee Ji Su, Ciechanover Aaron, Kim Bo Yeon, Kwon Yong Tae", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "reference": [ { "type": "PubMed", "id": "34893540", "url": "https://glygen.org/publication/PubMed/34893540" } ] }, { "title": "HLA Allele-Specific Quantitative Profiling of Type 1 Diabetic B Lymphocyte Immunopeptidome.", "journal": "Journal of proteome research", "date": "2022-01-07", "authors": "Sudhir Putty-Reddy, Lin Tai-Du, Zhang Qibin", "evidence": [ { "database": "IEDB", "id": "607837", "url": "https://www.iedb.org/epitope/607837" }, { "database": "IEDB", "id": "1859831", "url": "https://www.iedb.org/epitope/1859831" } ], "reference": [ { "type": "PubMed", "id": "34932366", "url": "https://glygen.org/publication/PubMed/34932366" } ] }, { "title": "Rift Valley fever virus Gn V5-epitope tagged virus enables identification of UBR4 as a Gn interacting protein that facilitates Rift Valley fever virus production.", "journal": "Virology", "date": "2022", "authors": "Bracci N, de la Fuente C, Saleem S, Pinkham C, Narayanan A, Garcia-Sastre A, Balaraman V, Richt JA, Wilson W, Kehn-Hall K", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "reference": [ { "type": "PubMed", "id": "35032865", "url": "https://glygen.org/publication/PubMed/35032865" } ] }, { "title": "Immunopeptidomic analysis of influenza A virus infected human tissues identifies internal proteins as a rich source of HLA ligands.", "journal": "PLoS pathogens", "date": "2022-01", "authors": "Nicholas Ben, Bailey Alistair, Staples Karl J, Wilkinson Tom, Elliott Tim, Skipp Paul", "evidence": [ { "database": "IEDB", "id": "175897", "url": "https://www.iedb.org/epitope/175897" }, { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "241528", "url": "https://www.iedb.org/epitope/241528" }, { "database": "IEDB", "id": "427293", "url": "https://www.iedb.org/epitope/427293" }, { "database": "IEDB", "id": "437318", "url": "https://www.iedb.org/epitope/437318" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "441072", "url": "https://www.iedb.org/epitope/441072" }, { "database": "IEDB", "id": "441519", "url": "https://www.iedb.org/epitope/441519" }, { "database": "IEDB", "id": "444312", "url": "https://www.iedb.org/epitope/444312" }, { "database": "IEDB", "id": "446446", "url": "https://www.iedb.org/epitope/446446" }, { "database": "IEDB", "id": "447449", "url": "https://www.iedb.org/epitope/447449" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "459480", "url": "https://www.iedb.org/epitope/459480" }, { "database": "IEDB", "id": "479903", "url": "https://www.iedb.org/epitope/479903" }, { "database": "IEDB", "id": "481713", "url": "https://www.iedb.org/epitope/481713" }, { "database": "IEDB", "id": "504446", "url": "https://www.iedb.org/epitope/504446" }, { "database": "IEDB", "id": "509357", "url": "https://www.iedb.org/epitope/509357" }, { "database": "IEDB", "id": "542799", "url": "https://www.iedb.org/epitope/542799" }, { "database": "IEDB", "id": "543334", "url": "https://www.iedb.org/epitope/543334" }, { "database": "IEDB", "id": "575426", "url": "https://www.iedb.org/epitope/575426" }, { "database": "IEDB", "id": "575460", "url": "https://www.iedb.org/epitope/575460" }, { "database": "IEDB", "id": "583773", "url": "https://www.iedb.org/epitope/583773" }, { "database": "IEDB", "id": "594293", "url": "https://www.iedb.org/epitope/594293" }, { "database": "IEDB", "id": "640633", "url": "https://www.iedb.org/epitope/640633" }, { "database": "IEDB", "id": "645125", "url": "https://www.iedb.org/epitope/645125" }, { "database": "IEDB", "id": "651868", "url": "https://www.iedb.org/epitope/651868" }, { "database": "IEDB", "id": "652125", "url": "https://www.iedb.org/epitope/652125" }, { "database": "IEDB", "id": "652546", "url": "https://www.iedb.org/epitope/652546" }, { "database": "IEDB", "id": "717602", "url": "https://www.iedb.org/epitope/717602" }, { "database": "IEDB", "id": "772977", "url": "https://www.iedb.org/epitope/772977" }, { "database": "IEDB", "id": "840487", "url": "https://www.iedb.org/epitope/840487" }, { "database": "IEDB", "id": "892512", "url": "https://www.iedb.org/epitope/892512" }, { "database": "IEDB", "id": "953609", "url": "https://www.iedb.org/epitope/953609" }, { "database": "IEDB", "id": "953668", "url": "https://www.iedb.org/epitope/953668" }, { "database": "IEDB", "id": "955028", "url": "https://www.iedb.org/epitope/955028" }, { "database": "IEDB", "id": "1007382", "url": "https://www.iedb.org/epitope/1007382" }, { "database": "IEDB", "id": "1368512", "url": "https://www.iedb.org/epitope/1368512" }, { "database": "IEDB", "id": "1780680", "url": "https://www.iedb.org/epitope/1780680" }, { "database": "IEDB", "id": "1984238", "url": "https://www.iedb.org/epitope/1984238" }, { "database": "IEDB", "id": "2005065", "url": "https://www.iedb.org/epitope/2005065" }, { "database": "IEDB", "id": "2006591", "url": "https://www.iedb.org/epitope/2006591" }, { "database": "IEDB", "id": "2007224", "url": "https://www.iedb.org/epitope/2007224" }, { "database": "IEDB", "id": "2007387", "url": "https://www.iedb.org/epitope/2007387" }, { "database": "IEDB", "id": "2007857", "url": "https://www.iedb.org/epitope/2007857" }, { "database": "IEDB", "id": "2007944", "url": "https://www.iedb.org/epitope/2007944" }, { "database": "IEDB", "id": "2008686", "url": "https://www.iedb.org/epitope/2008686" }, { "database": "IEDB", "id": "2008988", "url": "https://www.iedb.org/epitope/2008988" }, { "database": "IEDB", "id": "2010241", "url": "https://www.iedb.org/epitope/2010241" }, { "database": "IEDB", "id": "2011120", "url": "https://www.iedb.org/epitope/2011120" }, { "database": "IEDB", "id": "2011711", "url": "https://www.iedb.org/epitope/2011711" }, { "database": "IEDB", "id": "2012806", "url": "https://www.iedb.org/epitope/2012806" }, { "database": "IEDB", "id": "2013125", "url": "https://www.iedb.org/epitope/2013125" }, { "database": "IEDB", "id": "2013670", "url": "https://www.iedb.org/epitope/2013670" }, { "database": "IEDB", "id": "2013714", "url": "https://www.iedb.org/epitope/2013714" }, { "database": "IEDB", "id": "2013776", "url": "https://www.iedb.org/epitope/2013776" }, { "database": "IEDB", "id": "2015666", "url": "https://www.iedb.org/epitope/2015666" }, { "database": "IEDB", "id": "2019155", "url": "https://www.iedb.org/epitope/2019155" }, { "database": "IEDB", "id": "2021489", "url": "https://www.iedb.org/epitope/2021489" }, { "database": "IEDB", "id": "2022117", "url": "https://www.iedb.org/epitope/2022117" }, { "database": "IEDB", "id": "2022196", "url": "https://www.iedb.org/epitope/2022196" }, { "database": "IEDB", "id": "2022703", "url": "https://www.iedb.org/epitope/2022703" }, { "database": "IEDB", "id": "2022910", "url": "https://www.iedb.org/epitope/2022910" }, { "database": "IEDB", "id": "2023667", "url": "https://www.iedb.org/epitope/2023667" }, { "database": "IEDB", "id": "2025237", "url": "https://www.iedb.org/epitope/2025237" }, { "database": "IEDB", "id": "2025267", "url": "https://www.iedb.org/epitope/2025267" }, { "database": "IEDB", "id": "2026564", "url": "https://www.iedb.org/epitope/2026564" }, { "database": "IEDB", "id": "2026671", "url": "https://www.iedb.org/epitope/2026671" }, { "database": "IEDB", "id": "2026956", "url": "https://www.iedb.org/epitope/2026956" }, { "database": "IEDB", "id": "2027047", "url": "https://www.iedb.org/epitope/2027047" }, { "database": "IEDB", "id": "2027581", "url": "https://www.iedb.org/epitope/2027581" }, { "database": "IEDB", "id": "2028484", "url": "https://www.iedb.org/epitope/2028484" }, { "database": "IEDB", "id": "2029523", "url": "https://www.iedb.org/epitope/2029523" }, { "database": "IEDB", "id": "2029979", "url": "https://www.iedb.org/epitope/2029979" }, { "database": "IEDB", "id": "2030050", "url": "https://www.iedb.org/epitope/2030050" }, { "database": "IEDB", "id": "2030317", "url": "https://www.iedb.org/epitope/2030317" }, { "database": "IEDB", "id": "2030637", "url": "https://www.iedb.org/epitope/2030637" }, { "database": "IEDB", "id": "2030982", "url": "https://www.iedb.org/epitope/2030982" }, { "database": "IEDB", "id": "2031405", "url": "https://www.iedb.org/epitope/2031405" }, { "database": "IEDB", "id": "2033141", "url": "https://www.iedb.org/epitope/2033141" }, { "database": "IEDB", "id": "2033429", "url": "https://www.iedb.org/epitope/2033429" }, { "database": "IEDB", "id": "2033699", "url": "https://www.iedb.org/epitope/2033699" }, { "database": "IEDB", "id": "2033931", "url": "https://www.iedb.org/epitope/2033931" }, { "database": "IEDB", "id": "2034971", "url": "https://www.iedb.org/epitope/2034971" }, { "database": "IEDB", "id": "2036086", "url": "https://www.iedb.org/epitope/2036086" }, { "database": "IEDB", "id": "2036371", "url": "https://www.iedb.org/epitope/2036371" }, { "database": "IEDB", "id": "2037679", "url": "https://www.iedb.org/epitope/2037679" }, { "database": "IEDB", "id": "2037762", "url": "https://www.iedb.org/epitope/2037762" }, { "database": "IEDB", "id": "2042253", "url": "https://www.iedb.org/epitope/2042253" }, { "database": "IEDB", "id": "2042443", "url": "https://www.iedb.org/epitope/2042443" }, { "database": "IEDB", "id": "2042853", "url": "https://www.iedb.org/epitope/2042853" }, { "database": "IEDB", "id": "2042924", "url": "https://www.iedb.org/epitope/2042924" }, { "database": "IEDB", "id": "2043103", "url": "https://www.iedb.org/epitope/2043103" }, { "database": "IEDB", "id": "2043472", "url": "https://www.iedb.org/epitope/2043472" }, { "database": "IEDB", "id": "2045233", "url": "https://www.iedb.org/epitope/2045233" }, { "database": "IEDB", "id": "2045235", "url": "https://www.iedb.org/epitope/2045235" }, { "database": "IEDB", "id": "2045346", "url": "https://www.iedb.org/epitope/2045346" }, { "database": "IEDB", "id": "2046290", "url": "https://www.iedb.org/epitope/2046290" }, { "database": "IEDB", "id": "2047194", "url": "https://www.iedb.org/epitope/2047194" }, { "database": "IEDB", "id": "2047273", "url": "https://www.iedb.org/epitope/2047273" }, { "database": "IEDB", "id": "2048266", "url": "https://www.iedb.org/epitope/2048266" }, { "database": "IEDB", "id": "2048643", "url": "https://www.iedb.org/epitope/2048643" }, { "database": "IEDB", "id": "2049303", "url": "https://www.iedb.org/epitope/2049303" }, { "database": "IEDB", "id": "2049316", "url": "https://www.iedb.org/epitope/2049316" }, { "database": "IEDB", "id": "2050382", "url": "https://www.iedb.org/epitope/2050382" }, { "database": "IEDB", "id": "2050714", "url": "https://www.iedb.org/epitope/2050714" }, { "database": "IEDB", "id": "2051049", "url": "https://www.iedb.org/epitope/2051049" }, { "database": "IEDB", "id": "2051151", "url": "https://www.iedb.org/epitope/2051151" }, { "database": "IEDB", "id": "2051930", "url": "https://www.iedb.org/epitope/2051930" }, { "database": "IEDB", "id": "2052732", "url": "https://www.iedb.org/epitope/2052732" }, { "database": "IEDB", "id": "2053185", "url": "https://www.iedb.org/epitope/2053185" }, { "database": "IEDB", "id": "2053551", "url": "https://www.iedb.org/epitope/2053551" }, { "database": "IEDB", "id": "2053906", "url": "https://www.iedb.org/epitope/2053906" }, { "database": "IEDB", "id": "2053963", "url": "https://www.iedb.org/epitope/2053963" }, { "database": "IEDB", "id": "2055120", "url": "https://www.iedb.org/epitope/2055120" }, { "database": "IEDB", "id": "2055850", "url": "https://www.iedb.org/epitope/2055850" }, { "database": "IEDB", "id": "2055890", "url": "https://www.iedb.org/epitope/2055890" }, { "database": "IEDB", "id": "2056081", "url": "https://www.iedb.org/epitope/2056081" }, { "database": "IEDB", "id": "2058331", "url": "https://www.iedb.org/epitope/2058331" }, { "database": "IEDB", "id": "2058524", "url": "https://www.iedb.org/epitope/2058524" }, { "database": "IEDB", "id": "2058609", "url": "https://www.iedb.org/epitope/2058609" }, { "database": "IEDB", "id": "2060413", "url": "https://www.iedb.org/epitope/2060413" } ], "reference": [ { "type": "PubMed", "id": "35051231", "url": "https://glygen.org/publication/PubMed/35051231" } ] }, { "title": "Accurate MHC Motif Deconvolution of Immunopeptidomics Data Reveals a Significant Contribution of DRB3, 4 and 5 to the Total DR Immunopeptidome.", "journal": "Frontiers in immunology", "date": "2022", "authors": "Kaabinejadian Saghar, Barra Carolina, Alvarez Bruno, Yari Hooman, Hildebrand William H, Nielsen Morten", "evidence": [ { "database": "IEDB", "id": "489168", "url": "https://www.iedb.org/epitope/489168" }, { "database": "IEDB", "id": "1968004", "url": "https://www.iedb.org/epitope/1968004" } ], "reference": [ { "type": "PubMed", "id": "35154160", "url": "https://glygen.org/publication/PubMed/35154160" } ] }, { "title": "Promiscuity of Peptides Presented in HLA-DP Molecules from Different Immunogenicity Groups Is Associated With T-Cell Cross-Reactivity.", "journal": "Frontiers in immunology", "date": "2022", "authors": "Laghmouchi Aicha, Kester Michel G D, Hoogstraten Conny, Hageman Lois, de Klerk Wendy, Huisman Wesley, Koster Eva A S, de Ru Arnoud H, van Balen Peter, Klobuch Sebastian, van Veelen Peter A, Falkenburg J H Frederik, Jedema Inge", "evidence": [ { "database": "IEDB", "id": "1168155", "url": "https://www.iedb.org/epitope/1168155" } ], "reference": [ { "type": "PubMed", "id": "35251023", "url": "https://glygen.org/publication/PubMed/35251023" } ] }, { "title": "Tumour-associated antigenic peptides are present in the HLA class I ligandome of cancer cell line derived extracellular vesicles.", "journal": "Immunology", "date": "2022-06", "authors": "Kumar Pankaj, Boyne Caitlin, Brown Sydney, Qureshi Ayesha, Thorpe Peter, Synowsky Silvia A, Shirran Sally, Powis Simon J", "evidence": [ { "database": "IEDB", "id": "426187", "url": "https://www.iedb.org/epitope/426187" }, { "database": "IEDB", "id": "575426", "url": "https://www.iedb.org/epitope/575426" }, { "database": "IEDB", "id": "575460", "url": "https://www.iedb.org/epitope/575460" } ], "reference": [ { "type": "PubMed", "id": "35318648", "url": "https://glygen.org/publication/PubMed/35318648" } ] }, { "title": "Unmasking the suppressed immunopeptidome of EZH2-mutated diffuse large B-cell lymphomas through combination drug treatment.", "journal": "Blood advances", "date": "2022-07-26", "authors": "Bourne Christopher M, Mun Sung Soo, Dao Tao, Aretz Zita E H, Molvi Zaki, Gejman Ron S, Daman Andrew, Takata Katsuyoshi, Steidl Christian, Klatt Martin G, Scheinberg David A", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "575426", "url": "https://www.iedb.org/epitope/575426" } ], "reference": [ { "type": "PubMed", "id": "35561310", "url": "https://glygen.org/publication/PubMed/35561310" } ] }, { "title": "Soluble HLA peptidome of pleural effusions is a valuable source for tumor antigens.", "journal": "Journal for immunotherapy of cancer", "date": "2022-05", "authors": "Khazan-Kost Sofia, Cafri Gal, Melamed Kadosh Dganit, Mooshayef Navit, Chatterji Sumit, Dominissini Dan, Manor Sigal, Zisser Bracha, Broday Limor, Talalai Efrosiniia, Shemer Anat, Zadok Oranit, Ofek Efrat, Onn Amir, Admon Arie, Peled Michael", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "469366", "url": "https://www.iedb.org/epitope/469366" }, { "database": "IEDB", "id": "577760", "url": "https://www.iedb.org/epitope/577760" }, { "database": "IEDB", "id": "583773", "url": "https://www.iedb.org/epitope/583773" }, { "database": "IEDB", "id": "607837", "url": "https://www.iedb.org/epitope/607837" }, { "database": "IEDB", "id": "622086", "url": "https://www.iedb.org/epitope/622086" }, { "database": "IEDB", "id": "705980", "url": "https://www.iedb.org/epitope/705980" }, { "database": "IEDB", "id": "717602", "url": "https://www.iedb.org/epitope/717602" }, { "database": "IEDB", "id": "718575", "url": "https://www.iedb.org/epitope/718575" }, { "database": "IEDB", "id": "734569", "url": "https://www.iedb.org/epitope/734569" }, { "database": "IEDB", "id": "892512", "url": "https://www.iedb.org/epitope/892512" }, { "database": "IEDB", "id": "926906", "url": "https://www.iedb.org/epitope/926906" }, { "database": "IEDB", "id": "940334", "url": "https://www.iedb.org/epitope/940334" }, { "database": "IEDB", "id": "955028", "url": "https://www.iedb.org/epitope/955028" }, { "database": "IEDB", "id": "1084169", "url": "https://www.iedb.org/epitope/1084169" }, { "database": "IEDB", "id": "1084293", "url": "https://www.iedb.org/epitope/1084293" }, { "database": "IEDB", "id": "1207635", "url": "https://www.iedb.org/epitope/1207635" }, { "database": "IEDB", "id": "2261622", "url": "https://www.iedb.org/epitope/2261622" } ], "reference": [ { "type": "PubMed", "id": "35580925", "url": "https://glygen.org/publication/PubMed/35580925" } ] }, { "title": "Multi-Omic Analysis of Two Common P53 Mutations: Proteins Regulated by Mutated P53 as Potential Targets for Immunotherapy.", "journal": "Cancers", "date": "2022-08-17", "authors": "Vadakekolathu Jayakumar, Boocock David J, Pandey Kirti, Guinn Barbara-Ann, Legrand Antoine, Miles Amanda K, Coveney Clare, Ayala Rochelle, Purcell Anthony W, McArdle Stephanie E", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "436141", "url": "https://www.iedb.org/epitope/436141" }, { "database": "IEDB", "id": "438659", "url": "https://www.iedb.org/epitope/438659" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "469366", "url": "https://www.iedb.org/epitope/469366" }, { "database": "IEDB", "id": "471688", "url": "https://www.iedb.org/epitope/471688" }, { "database": "IEDB", "id": "481713", "url": "https://www.iedb.org/epitope/481713" }, { "database": "IEDB", "id": "504446", "url": "https://www.iedb.org/epitope/504446" }, { "database": "IEDB", "id": "505055", "url": "https://www.iedb.org/epitope/505055" }, { "database": "IEDB", "id": "542799", "url": "https://www.iedb.org/epitope/542799" }, { "database": "IEDB", "id": "543716", "url": "https://www.iedb.org/epitope/543716" }, { "database": "IEDB", "id": "545696", "url": "https://www.iedb.org/epitope/545696" }, { "database": "IEDB", "id": "575387", "url": "https://www.iedb.org/epitope/575387" }, { "database": "IEDB", "id": "578116", "url": "https://www.iedb.org/epitope/578116" }, { "database": "IEDB", "id": "692404", "url": "https://www.iedb.org/epitope/692404" }, { "database": "IEDB", "id": "699405", "url": "https://www.iedb.org/epitope/699405" }, { "database": "IEDB", "id": "707990", "url": "https://www.iedb.org/epitope/707990" }, { "database": "IEDB", "id": "733934", "url": "https://www.iedb.org/epitope/733934" }, { "database": "IEDB", "id": "884927", "url": "https://www.iedb.org/epitope/884927" }, { "database": "IEDB", "id": "1000534", "url": "https://www.iedb.org/epitope/1000534" }, { "database": "IEDB", "id": "1037463", "url": "https://www.iedb.org/epitope/1037463" }, { "database": "IEDB", "id": "1045035", "url": "https://www.iedb.org/epitope/1045035" }, { "database": "IEDB", "id": "1051506", "url": "https://www.iedb.org/epitope/1051506" }, { "database": "IEDB", "id": "1074312", "url": "https://www.iedb.org/epitope/1074312" }, { "database": "IEDB", "id": "1287579", "url": "https://www.iedb.org/epitope/1287579" }, { "database": "IEDB", "id": "1324271", "url": "https://www.iedb.org/epitope/1324271" }, { "database": "IEDB", "id": "1599370", "url": "https://www.iedb.org/epitope/1599370" }, { "database": "IEDB", "id": "1917541", "url": "https://www.iedb.org/epitope/1917541" }, { "database": "IEDB", "id": "1978672", "url": "https://www.iedb.org/epitope/1978672" }, { "database": "IEDB", "id": "2138201", "url": "https://www.iedb.org/epitope/2138201" }, { "database": "IEDB", "id": "2138465", "url": "https://www.iedb.org/epitope/2138465" }, { "database": "IEDB", "id": "2138914", "url": "https://www.iedb.org/epitope/2138914" }, { "database": "IEDB", "id": "2140413", "url": "https://www.iedb.org/epitope/2140413" }, { "database": "IEDB", "id": "2140534", "url": "https://www.iedb.org/epitope/2140534" }, { "database": "IEDB", "id": "2140759", "url": "https://www.iedb.org/epitope/2140759" }, { "database": "IEDB", "id": "2141973", "url": "https://www.iedb.org/epitope/2141973" }, { "database": "IEDB", "id": "2142578", "url": "https://www.iedb.org/epitope/2142578" }, { "database": "IEDB", "id": "2144461", "url": "https://www.iedb.org/epitope/2144461" } ], "reference": [ { "type": "PubMed", "id": "36010968", "url": "https://glygen.org/publication/PubMed/36010968" } ] }, { "title": "The Autophagy Receptor TAX1BP1 (T6BP) improves antigen presentation by MHC-II molecules.", "journal": "EMBO reports", "date": "2022-12-06", "authors": "Sarango Gabriela, Richetta Cl\u00e9mence, Pereira Mathias, Kumari Anita, Ghosh Michael, Bertrand Lisa, Pionneau C\u00e9dric, Le Gall Morgane, Gr\u00e9goire Sylvie, Jeger-Madiot Rapha\u00ebl, Rosoy Elina, Subra Fr\u00e9d\u00e9ric, Delelis Olivier, Faure Mathias, Esclatine Audrey, Graff-Dubois St\u00e9phanie, Stevanovi\u0107 Stefan, Manoury B\u00e9n\u00e9dicte, Ramirez Bertha Cecilia, Moris Arnaud", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "441072", "url": "https://www.iedb.org/epitope/441072" }, { "database": "IEDB", "id": "542799", "url": "https://www.iedb.org/epitope/542799" }, { "database": "IEDB", "id": "630675", "url": "https://www.iedb.org/epitope/630675" }, { "database": "IEDB", "id": "1118129", "url": "https://www.iedb.org/epitope/1118129" }, { "database": "IEDB", "id": "2177890", "url": "https://www.iedb.org/epitope/2177890" } ], "reference": [ { "type": "PubMed", "id": "36215666", "url": "https://glygen.org/publication/PubMed/36215666" } ] }, { "title": "Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes.", "journal": "Nature communications", "date": "2022-10-14", "authors": "Mayer Rupert L, Verbeke Rein, Asselman Caroline, Aernout Ilke, Gul Adillah, Eggermont Denzel, Boucher Katie, Thery Fabien, Maia Teresa M, Demol Hans, Gabriels Ralf, Martens Lennart, B\u00e9cavin Christophe, De Smedt Stefaan C, Vandekerckhove Bart, Lentacker Ine, Impens Francis", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "441072", "url": "https://www.iedb.org/epitope/441072" }, { "database": "IEDB", "id": "481713", "url": "https://www.iedb.org/epitope/481713" }, { "database": "IEDB", "id": "505055", "url": "https://www.iedb.org/epitope/505055" }, { "database": "IEDB", "id": "618628", "url": "https://www.iedb.org/epitope/618628" }, { "database": "IEDB", "id": "623545", "url": "https://www.iedb.org/epitope/623545" }, { "database": "IEDB", "id": "630675", "url": "https://www.iedb.org/epitope/630675" }, { "database": "IEDB", "id": "640633", "url": "https://www.iedb.org/epitope/640633" }, { "database": "IEDB", "id": "866511", "url": "https://www.iedb.org/epitope/866511" }, { "database": "IEDB", "id": "884934", "url": "https://www.iedb.org/epitope/884934" }, { "database": "IEDB", "id": "1287579", "url": "https://www.iedb.org/epitope/1287579" }, { "database": "IEDB", "id": "2245261", "url": "https://www.iedb.org/epitope/2245261" }, { "database": "IEDB", "id": "2247909", "url": "https://www.iedb.org/epitope/2247909" } ], "reference": [ { "type": "PubMed", "id": "36241641", "url": "https://glygen.org/publication/PubMed/36241641" } ] }, { "title": "Direct identification of HLA class I and class II-restricted T cell epitopes in pancreatic cancer tissues by mass spectrometry.", "journal": "Journal of hematology & oncology", "date": "2022-10-25", "authors": "Fujiwara Kenji, Shao Yingkuan, Niu Nan, Zhang Tengyi, Herbst Brian, Henderson Mackenzie, Muth Stephen, Zhang Pingbo, Zheng Lei", "evidence": [ { "database": "IEDB", "id": "426187", "url": "https://www.iedb.org/epitope/426187" }, { "database": "IEDB", "id": "431157", "url": "https://www.iedb.org/epitope/431157" }, { "database": "IEDB", "id": "446446", "url": "https://www.iedb.org/epitope/446446" }, { "database": "IEDB", "id": "469366", "url": "https://www.iedb.org/epitope/469366" }, { "database": "IEDB", "id": "892512", "url": "https://www.iedb.org/epitope/892512" }, { "database": "IEDB", "id": "1023235", "url": "https://www.iedb.org/epitope/1023235" }, { "database": "IEDB", "id": "1051506", "url": "https://www.iedb.org/epitope/1051506" } ], "reference": [ { "type": "PubMed", "id": "36284347", "url": "https://glygen.org/publication/PubMed/36284347" } ] }, { "title": "Retina-arrestin specific CD8+ T cells are not implicated in HLA-A29-positive birdshot chorioretinitis.", "journal": "Clinical immunology (Orlando, Fla.)", "date": "2023-02", "authors": "Venema W J, Hiddingh S, Janssen G M C, Ossewaarde-van Norel J, van Loon N Dam, de Boer J H, van Veelen P A, Kuiper J J W", "evidence": [ { "database": "IEDB", "id": "426187", "url": "https://www.iedb.org/epitope/426187" }, { "database": "IEDB", "id": "427253", "url": "https://www.iedb.org/epitope/427253" } ], "reference": [ { "type": "PubMed", "id": "36581221", "url": "https://glygen.org/publication/PubMed/36581221" } ] }, { "title": "Extracellular arginine availability modulates eIF2\u03b1 O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis.", "journal": "Journal of biomedical science", "date": "2023-05-22", "authors": "Hung Yu-Wen, Ouyang Ching, Ping Xiaoli, Qi Yue, Wang Yi-Chang, Kung Hsing-Jien, Ann David K", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q5T4S7", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q5T4S7" } ], "reference": [ { "type": "PubMed", "id": "37217939", "url": "https://glygen.org/publication/PubMed/37217939" } ] }, { "title": "`Two Birds One Stone` Strategy for the Site-Specific Analysis of Core Fucosylation and O-GlcNAcylation.", "journal": "Journal of the American Chemical Society", "date": "2023-07-26", "authors": "Luo Yawen, Wang Yuqiu, Tian Yinping, Zhou Hu, Wen Liuqing", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q5T4S7", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q5T4S7" } ], "reference": [ { "type": "PubMed", "id": "37340703", "url": "https://glygen.org/publication/PubMed/37340703" } ] }, { "title": "N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity.", "journal": "Nature communications", "date": "2023-10-27", "authors": "Varland Sylvia, Silva Rui Duarte, Kjos\u00e5s Ine, Faustino Alexandra, Bogaert Annelies, Billmann Maximilian, Boukhatmi Hadi, Kellen Barbara, Costanzo Michael, Drazic Adrian, Osberg Camilla, Chan Katherine, Zhang Xiang, Tong Amy Hin Yan, Andreazza Simonetta, Lee Juliette J, Nedyalkova Lyudmila, U\u0161aj Matej, Whitworth Alexander J, Andrews Brenda J, Moffat Jason, Myers Chad L, Gevaert Kris, Boone Charles, Martinho Rui Gon\u00e7alo, Arnesen Thomas", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "reference": [ { "type": "PubMed", "id": "37891180", "url": "https://glygen.org/publication/PubMed/37891180" } ] }, { "title": "Targeting of intracellular oncoproteins with peptide-centric CARs.", "journal": "Nature", "date": "2023-11", "authors": "Yarmarkovich Mark, Marshall Quinlen F, Warrington John M, Premaratne Rasika, Farrel Alvin, Groff David, Li Wei, di Marco Moreno, Runbeck Erin, Truong Hau, Toor Jugmohit S, Tripathi Sarvind, Nguyen Son, Shen Helena, Noel Tiffany, Church Nicole L, Weiner Amber, Kendsersky Nathan, Martinez Dan, Weisberg Rebecca, Christie Molly, Eisenlohr Laurence, Bosse Kristopher R, Dimitrov Dimiter S, Stevanovic Stefan, Sgourakis Nikolaos G, Kiefel Ben R, Maris John M", "evidence": [ { "database": "IEDB", "id": "194067", "url": "https://www.iedb.org/epitope/194067" }, { "database": "IEDB", "id": "441519", "url": "https://www.iedb.org/epitope/441519" }, { "database": "IEDB", "id": "450177", "url": "https://www.iedb.org/epitope/450177" }, { "database": "IEDB", "id": "575426", "url": "https://www.iedb.org/epitope/575426" }, { "database": "IEDB", "id": "772977", "url": "https://www.iedb.org/epitope/772977" }, { "database": "IEDB", "id": "1084169", "url": "https://www.iedb.org/epitope/1084169" } ], "reference": [ { "type": "PubMed", "id": "37938771", "url": "https://glygen.org/publication/PubMed/37938771" } ] }, { "title": "Insights into the recognition mechanism in the UBR box of UBR4 for its specific substrates.", "journal": "Communications biology", "date": "2023-11-29", "authors": "Jeong Da Eun, Lee Hye Seon, Ku Bonsu, Kim Cheol-Hee, Kim Seung Jun, Shin Ho-Chul", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "reference": [ { "type": "PubMed", "id": "38030679", "url": "https://glygen.org/publication/PubMed/38030679" } ] }, { "title": "UBE2A and UBE2B are recruited by an atypical E3 ligase module in UBR4.", "journal": "Nature structural & molecular biology", "date": "2024-02", "authors": "Barnsby-Greer Lucy, Mabbitt Peter D, Dery Marc-Andre, Squair Daniel R, Wood Nicola T, Lamoliatte Frederic, Lange Sven M, Virdee Satpal", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "reference": [ { "type": "PubMed", "id": "38182926", "url": "https://glygen.org/publication/PubMed/38182926" } ] }, { "title": "Stress response silencing by an E3 ligase mutated in neurodegeneration.", "journal": "Nature", "date": "2024-02", "authors": "Haakonsen Diane L, Heider Michael, Ingersoll Andrew J, Vodehnal Kayla, Witus Samuel R, Uenaka Takeshi, Wernig Marius, Rap\u00e9 Michael", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "reference": [ { "type": "PubMed", "id": "38297121", "url": "https://glygen.org/publication/PubMed/38297121" } ] }, { "title": "O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis.", "journal": "Frontiers in immunology", "date": "2024", "authors": "Vang Shia, Helton Eric Scott, Guo Yiming, Burpee Bailey, Rose Elex, Easter Molly, Bollenbecker Seth, Hirsch Meghan June, Matthews Emma Lea, Jones Luke Isaac, Howze Patrick Henry, Rajasekaran Vasanthi, Denson Rebecca, Cochran Phillip, Attah Isaac Kwame, Olson Heather, Clair Geremy, Melkani Girish, Krick Stefanie, Barnes Jarrod Wesley", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q5T4S7", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q5T4S7" } ], "reference": [ { "type": "PubMed", "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916" } ] }, { "title": "IKZF1 and UBR4 gene variants drive autoimmunity and Th2 polarization in IgG4-related disease.", "journal": "The Journal of clinical investigation", "date": "2024-06-13", "authors": "Liu Qingxiang, Zheng Yanyan, Sturmlechner Ines, Jain Abhinav, Own Maryam, Yang Qiankun, Zhang Huimin, Pinto E Vairo Filippo, Cerosaletti Karen, Buckner Jane H, Warrington Kenneth J, Koster Matthew J, Weyand Cornelia M, Goronzy J\u00f6rg J", "evidence": [ { "database": "RefSeq", "id": "NP_065816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065816" } ], "reference": [ { "type": "PubMed", "id": "38885295", "url": "https://glygen.org/publication/PubMed/38885295" } ] }, { "title": "Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics.", "journal": "Journal of proteome research", "date": "2024-10-04", "authors": "Hou Chunyan, Wu Ci, Wu Zichun, Cheng Yifan, Li Weiyu, Sun Hui, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q5T4S7", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q5T4S7" }, { "database": "O-GlcNAc Atlas", "id": "Q5T4S7", "url": "https://oglcnac.org/atlas/detail/Q5T4S7" } ], "reference": [ { "type": "PubMed", "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247" } ] }, { "title": "Molecular basis of SIFI activity in the integrated stress response.", "journal": "Nature", "date": "2025-07", "authors": "Yang Zhi, Haakonsen Diane L, Heider Michael, Witus Samuel R, Zelter Alex, Beschauner Tobias, MacCoss Michael J, Rap\u00e9 Michael", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "reference": [ { "type": "PubMed", "id": "40328314", "url": "https://glygen.org/publication/PubMed/40328314" } ] }, { "title": "Architecture of the UBR4 complex, a giant E4 ligase central to eukaryotic protein quality control.", "journal": "Science (New York, N.Y.)", "date": "2025-08-28", "authors": "Grabarczyk Daniel B, Ehrmann Julian F, Murphy Paul, Yang Woo Seok, Kurzbauer Robert, Bell Lillie E, Deszcz Luiza, Neuhold Jana, Schleiffer Alexander, Shulkina Alexandra, Lee Juyeon, Shin Jin Seok, Meinhart Anton, Versteeg Gijs A, Zavodszky Eszter, Song Hyun Kyu, Hegde Ramanujan S, Clausen Tim", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "reference": [ { "type": "PubMed", "id": "40875847", "url": "https://glygen.org/publication/PubMed/40875847" } ] }, { "title": "Genetic manipulation of OGT enhances NK cell-mediated cytotoxicity in tumor immunity.", "journal": "Journal of advanced research", "date": "2025-09-04", "authors": "Oh Se-Chan, Jeon Bong Chan, Jang In-Hwan, Song Mi-Ran, Hwang Heeyoun, An Dasom, Yue Liu, Jung Yuri, Lee Yunhee, Jo Seona, Park Sung-Kyun, Kim Tae-Don", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q5T4S7", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q5T4S7" } ], "reference": [ { "type": "PubMed", "id": "40914422", "url": "https://glygen.org/publication/PubMed/40914422" } ] }, { "title": "Targeting of proteins to granule subsets is determined by timing and not by sorting: The specific granule protein NGAL is localized to azurophil granules when expressed in HL-60 cells.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1996", "authors": "Le Cabec V, Cowland JB, Calafat J, Borregaard N", "evidence": [ { "database": "Reactome", "id": "R-HSA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6798695" } ], "reference": [ { "type": "PubMed", "id": "8692836", "url": "https://glygen.org/publication/PubMed/8692836" } ] }, { "title": "Two distinct proteolytic processes in the generation of a major histocompatibility complex class I-presented peptide.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1997", "authors": "Craiu A, Akopian T, Goldberg A, Rock KL", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "9380723", "url": "https://glygen.org/publication/PubMed/9380723" } ] }, { "title": "Interferon-gamma can stimulate post-proteasomal trimming of the N terminus of an antigenic peptide by inducing leucine aminopeptidase.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Beninga J, Rock KL, Goldberg AL", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "9668046", "url": "https://glygen.org/publication/PubMed/9668046" } ] } ], "pathway": [ { "id": "hsa:23352", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:23352", "resource": "KEGG Pathway" }, { "id": "R-HSA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" }, { "id": "R-HSA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" }, { "id": "R-HSA-9920588", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9920588", "resource": "Reactome", "description": "Dengue virus activates/modulates innate and adaptive immune responses" } ], "orthologs": [ { "uniprot_canonical_ac": "A0AC58IL79-1", "protein_name": "E3 ubiquitin-protein ligase UBR4 isoform X1", "gene_name": "ubr4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MASSGGDGEPEWTAAVRPLLSASYTAFETKELPQLIGSIINSESEILHHDKQYEPFYSSFVALSAHYITTVCGQIPRNQLLSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELPSPVNPELRHKEVQMNFFNQLTSVFNPDISVLASPSAHMQSENECDEQTTTDQATQAKMKNAFISQNVSSLQELGGSEKLLRVCLNLPYFLRYINRFQDAVSANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLTPGRLLDVTVLALSCLYAGVSVATCMAILQVGSGLQLRSASTGSKEEDYENDAATIVQKCLEIYEMIGQAISNSRRAGGEHYQNFQLLGAWCLLNSLYLILNLSPTALADKGKEKDPLAALRVRDIATRTKDGAGSPKLGPGKGHQGFGVLSVILANHSIKLLTSLFQDLQVEALHRLCCVIQGWASDGPPAELNIMAQSTSIQRVQRLIDSVPLTNLLFTLLSTSYKKACVLQRQRKGSVSSDASASTDSNTYYEDDFSSTEEDSSQAEYRVCLWFTELVSGLRSLRDFFRSFLSTARFSRRTAVRPESAERRQERTKAACFSDDDSEPILGLWFEETISPSKEKVAPPPPPPPPPLETSPRLKSPSKLNTVENGNILASRKDPELFLSLASSILNFITTSMLKSRNNFIRNYLSVSLTEQHMATLASIIKDVDKDVKGSSDDEFASALYHFNHSLVTSDLPSPSLQNTLLQQLGVAPFSEGPWPMYIHPQSLSVLSRLLLIWQHKASQQGEPDVPECMKVWERFVGTLKQHTLQGAVPADEDLNVEHLQLLLLIFHNFSEKGRRTVLTLCMQAIAEIASNADSQLQAVPLNLARILLVFDYLLHQYSKAPVYLFEQVQYNLLTPLASSASAGQDGGKRGAVPLYYGFKEVEENWAKHCSAGRNSTVQPKFYCVLSPEASEDDRSRLDGKVFQVLFNGAVKYDDMYSSLISLLAAGSRFDTARRQENKPITPVEACSLQYYFLVLWKILGVLPPSKAYIEQLKSGNSDPSESDILHTLRWSSRLRVSTYVNWIKEHLVKQGMKADLATSLIEVASTKCSAVKYDVELAEEYIARQISSFCCVDPNSILPLHQVPSLQTIYTLDAVISKVQVSLDEHFSKIAADTDPNKSSEITKNLLPATLQLIDVYTAFTRSYLLMSLPEEGENKPTEAKLQGYAAVLSIGSTRCKANLLGQTVMQNLPSAVQTLCETWNNIHTNEFPNIGSWRNAFANDTIPSESYISAIQAAHLGTLSNQSLPLASSLKHILLSLVRLTGDLIVTEELNSPQVIRTLLPLLLESSTESVAEICSTSLERILGPAESDAFLALVYERLITGCYNIIANHSDPNSGLDETILEECLQYLEKQLESSQVRKAMEEFFSFSGELVQIMMATANENLSAKFCNRVLKFFTKLFQLTEKSPNPSLLCLCGSLAQLACVEPSRLQAWLRRMTASPPKDSDQLDTVQENRQLLQLLTSYIVRDNSQVGEGVCTVLLSTLIPMATEMLASGDGAGFPELMVIMATLASAGQGAGHLQLHRAAIDWLTRCKKYLYQKNVVEKVTANVSQGKHASMLECACHIISYLADVMNALRQSSGQGSSQLLMDGEEKAIEVDSDWVEELAVEEDDSQAEDSDEDSLCNKLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCQVRPNTSGHHGKRATAALVKRSPSSGMSSTMKESSAFQSELRMPESAIRHQSSSPADKGKVTICDGKNSDDDKPKKSSVCKNIEGCREDLLIQVASSSTAALVLELLIFLMDAIQTNFQQASAVGSSSRAQHALNELHTQDKTVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMCVLSSPHGRRQHLAVSHEKGKITVLQLSALLKQADSSKRKLTLTRLASAPVPFTVLSLTGNPCNEDYLAVCGLKDCHVLTFSSTGSVSDHLVLHPQLATGNFIIKAIWLPGSQTELAIITADFVKIYDLSVDALSPMYYFLLPSSKIRDATFLFNEEGKNIIVIMSSAGYMYTQVMDESSSAQHGPFYVTNVLEINHEDLKDSNGQVAGGGVSVYYSHVLQMLFFSYSQGKSFAATVSRSNMETQRLFTINVKGSNGGSKTSPALCQWSEVMNHPGLVCCVQQTTGIPLVIMLKPDTFLIQEIKTLPAKAKIQDMVAIRHTASNEQQRTTMILLCEDGSLRIYMANVENTSYWLQPSLQPSSVISIMKPVRKRKTATATTRTSSQVTFPVDFFEHNQQLTEVEFGGNDLLQVYNGQQIKHRLNSTGMYVANTKPGGFTVEVVNNNNSMVMTGMRVQVGTQAIERAPSYIEIFGRTMQLNLTRSRWFDFPFTREEALQADKKLSIFIGASVDPAGVTMLDSIKIYGKTKEQFGWPDEPPEDFPSAAVNNVCSPNLNQGNGTGESDVTSPITTSGTVLESCETESLSALDRLVVSSLEALESCFAVGSLNEKEKNKVAALELATLLLSIPTPAGVQQQTKGLLASLHTSRTAYHNHKDQSLLSNAVQSLNACSKEGKELDPDVFQRLVITARSIAIMRPNNLVHFTESRLPQSDTDVGDDGLKQADTESCSFIMQLVTNFWKLHALKPKNAFLAPACLPGLTHIEATVNALVDIIHGYCTCELDYINVASKIYMQMLLCPDTSVSFACKQALIRVLRPRNKRRHVTLPSPPRSNTPMGDKDDDDDDDADDKMQPSNMTGGEGGRQESQEQNEVDHGDFEMVSESMVLETAENVNNGNPSPLEALLAGAEGFPPMLDIPPDADDETMVELAIALSLQQDQQGSSSSALGLQSLGLSGQAPSSSSLDAGTLSDTTASALVMLSAPASDDEGSTAATDGSTLRTSPAEHGGSVGSESGGSAIDSVAGEHNVSGRSSAYGDTTVEGHPAGPGSVSSSTGAISTTTAQHEGEGSEGEGETEGDIHTSNRLHMVRLMLLERLLQHLSQLHTVGGVQAIPYMQVILMLTTDLDGEDEKDKGALDDLLAQLIAELGMHKKDVSKKNERSSINEVHLVIMRLLSVFMSRTKSGSKSSSESSSLISNATATALLSMGAIDYCLHVLKSLLEFWKTQQGEEEPTATSQLLKPHTSSSPPDMSPFFLRQYVKGHAADVFEAYSQLLTEMVLRLPYQIKKIADANPRIPPPIFDHSWFYFLSEYLMIQQTPFVRRQVRKLLLFICGSKEKYRQLRDLHTLDSHVRGIKKLLEEQGIFLRGGIVTATSGSALQYDTLISLMEHLKACAEIATQRTINWQKFCMKDDSVLYFLLQVSFLVDEGVSPVLLQLLSCALCGSKVMAASSGSSGGGSGTSQPSQSKSSSKKSKKEDKEKDKEGDGAGSQEDQLCTALVSQLNKFADKETLIQFLRCFLLESNSSSVRWQAHCLTLHIYRNSNKSQQELLLDLMWAIWPELPAYGRKAAQFVDLLGYFSLKTPQTEKKLKEYSQKAVEILRAQNHILTNHPNSNIYNTLSRLVEFDGFYLESDPCLVCNNPEVPFSNIKLSSIKVDTRYTTTQQVVKLIGSHTISKVTVKIGDLKRTKMVRTINLYYNNRTVQAIVELKNKPARWHKAKKVQLTPGQTEVKIDLPLPIVASNLMIEFSDFYENYQASTETLQCPRCSASVPANPGVCGNCGENVYQCHKCRSINYDEKDPFLCNACGFCKYARFDFMLYAKPCCAVDPIENEEDRKKAVTNINTLLDKADRVYHQLMGHRPQLESLLSKVNEAAPEKPQDDTGAGAGLGTSTASVNRYIQQLAQEYSGDCKTSFDELSKIIQKVLASRKELLEYDLHQREAATKSSRTSAQQTFTASQYRALSVLGCGHTSSTKCYGCASAVTGHCITLLRALATNPAIRQILVLQGLIRELFEYNLRRGTGAMREEVRQLVCLLTRDHPEATQQMNDLIIAKVSAALKGHWANPDLVSSLQYEMLLLTDSIAKEGGCWELRLRCALSLFLMAVNIKTPVVVENITLMCLRILQKLIKPPAPTSKKNKDAAVESLTTVKPYNNEIHAQAQLWLKKEPKASYEAWKKCLPARCQETVSKPSNKAEIRRQYLMEKYVWKWKQFMRSRSEGLFPRLLKLGHNNWLRQVLFTPATQAARQAACTIVEALTTIPSRKQQVLDLLTSYLDELSIAGECAAEYLALYQKLIKPAHWKVYLAARGVLPYIGNLITKEIAHLLALEEATLSTDLQQGYALKSLTGLLSSFVEVESIKRHFKSRLVGTVLNGYLCLRKLVVQRTKLIDETQDMLLEMLEDMTTGTESETKAFMAVCIETAKRYNLDDYRTPVFIFERLCSIIYPEENEVTEFFVTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLEDDSGMELLVNNKIISLDLSVAEVYKKVWCPTNEGEPMRIIYRMRGLLGDATEEFIESLDSTTDEEEDDEEVYKMAGVMAQCGGLECMLNRLSGIKDFKQGRHLLTVLLKLFSYCVKVKINRQQLVKPEMNTLNVMLGTLNLALVAEQESKDSGGASIAEQVLSIMEIILDEANAETVSEDKGNLLLTGDKDQLVMLLDQINTLFVRSNPSVLQGLLRIIPYLSFGELEKMHILVERFKPCCNFDKYDEEHSADDKVFLDCFCKIAAGIKNNSNGHQLKDLILQKGITQSALDYMKKQIPCAKNLDADVWKKFLARPALPFILRLLRGLATQHPPTQMLIGTDSITNLHKLEQVSSDEGIGTLAENLLEALREHADVNLKIDAARRETRAEKKRMAMAMRQKALGTLGMTTNEKGQVVTKTSLLKQMEELIEEPGLTCCICREGYKFQPTKVLGIYTFTKRVSLEEFENKPRKQQGYSTVSHFNIVHYDCHLAAVRLARGREEWESAALQNANTKCNGLLPVWGPHVPESAFATCLARHNTYLQECTGQREPTYQLNIHDTKLLFLRFAMEQSFSVDTGGGGRESNIHLIPYIIHTVLYVLNTTRATSREEKNLQSFLEQPCEKWMETSYEVDGPHYFTILAMHILPPERWRTTRVDILRRLLVTAHARKVSPGGANKLTDKAVKEYAVYRSPLLFWGLVDLIYDMFRKVPTSNTEGGWSFSLAEYIRHNDMPIYEASERVLRAFQDELMPAESFSEFLDVVGLLSDIPDPDAFLQDLLNSVP", "length": 5240 }, "evidence": [ { "id": "RGD:1563121", "url": "https://alliancegenome.org/gene/RGD:1563121#orthology", "database": "AGR" }, { "id": "HGNC:30313", "url": "https://alliancegenome.org/gene/HGNC:30313#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-090313-341", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-090313-341#orthology", "database": "AGR" }, { "id": "MGI:1916366", "url": "https://alliancegenome.org/gene/MGI:1916366#orthology", "database": "AGR" }, { "id": "FB:FBgn0011230", "url": "https://alliancegenome.org/gene/FB:FBgn0011230#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A2AN08-1", "protein_name": "E3 ubiquitin-protein ligase UBR4", "gene_name": "Ubr4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATSGGEEAAAAAPAPGAPATGQDTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCSLIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPVSPELRQKEVQMNFLNQLTSVFNPRTVPSPPISPQALVEGENDEQSSPDQVSAAKTKSVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYINRFQDAVVANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRTGSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHFQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSRTKEGVGSPKLGPGKGHQGFGVLSVILANHAIKLLASLFQDLQVEALHKGWETDGPPAVLSIMAQSTSTQRIQRLIDSVPLTNLLLTLLSTSYRKACVLQRQRKGSMSSDASASTDSNTYYEDDFSSTEEDSSQDDDSEPILGQWFEETISPSKEKAAPPPPPPPPPLESSPRVKSPNKQASGEKGNILASRKDPELFSGLASNILNFITTSMLNSRNSFIRSYLSASLSEHHMATLASIIKEVDKDGLKGSSDEDFAAALYHFNHSLVTSDLQSPNLQNTLLQQLGVAPFSEGPWPLYIHPQGLSVLSRLLLIWQHKAGAQGDPDVPECLKVWDRFLTTMKQNALQGVVPSETEDLNVEHLQLLLLIFHSFSEKGRRAILTMLVQSIQELSVNMEVQMRTAPLILARLLLIFDYLLHQYSKAPVYLFEQVQHNLLSPPFGWASGSQDSSSRRANTPLYHGFKEVEENWSKHFSSDAAPQPRFYCVLSTEASEEDLNRLDSEACEVLFSKPVKYDELYSSLTTLLAAGSQLDTTRRKEKKNVTALEACALQYYFLILWRILGILPPSKTYMNQLAMNSPEMSECDILHTLRWSSRLRISSYVSWIKDHLIKQGMKPEHAGSLIELAASKCSSVKYDVEIVEEYFARQISSFCSIDCTAVLQLHEIPSLQSIYTLDAAVSKVQVSLDEHFSKMAAETDPHKSSEITKNLLPATLQLIDTYASFTRAYLLQNLNEEGSTEKPSQEKLHGFAAVLAIGSSRCKANTLGPTLVQNLPSSVQSVCESWNNINTNEFPNIGSWRNAFANDTIPSESYISAVQAAHLGTLCGQSLPLAASLKHTLLSLVRLTGDLIVWSDEMNPAQVIRTLLPLLLESSTESAAEISSNSLERILGPAESDEFLARVYEKLITGCYNILANHADPNSGLDESILEECLQYLEKQLESSQARKAMEEFFSDGGELVQIMMATANEDLSAKFCNRVLKFFTKLFQLTEKSPNPSLLHLCGSLAQLACVEPVRLQAWLTRMTTSPPKDSDQLEVIQENRQLLQLLTTYIVRENSQVGEGVCAVLLGTLTPMATDMLANGDGTGFPELMVVMATLASAGQGAGHLQLHNAAVDWLGRCKKYLSQKNVVEKLNANVMHGKHVMVLECTCHIMSYLADVTNALSQSNGQGPSHLSVDGEERAIEVDSDWVEELAVEEEDSQAEDSDEDSLCNKLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCLALVKRTPSSGMSSTMKESAFQSEPRVSESLVRHASTSPADKAKVTISDGKVTDEEKPKKSSLCRTVEGCREELQNQANFSFAPLVLDMLSFLMDAIQTNFQQASAVGSSSRAQQALSELHTVDKGVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMCVLSSPHGRRQHLAVSHEKGKITVLQLSALLKQADSSKRKLTLTRLASAPVPFTVLSLTGNPCKEDYLAVCGLKDCHVLTFSSSGSVSDHLVLHPQLATGNFIIKAVWLPGSQTELAIVTADFVKIYDLSIDALSPTFYFLLPSSKIRDVTFLFNEEGKNIIVIMSSAGYMYTQLMEEASSAQQGPFYVTNVLEINHEDLKDSNSQVAGGGVSVYYSHVLQMLFFSYSQGRSFAATVSRSTLEVLQLFPINIKSSNGGSKTSPALCQWSEVMNHPGLVCCVQQTTGVPLVVMVKPGTFLIQEIKTLPAKAKIQDMVAIRHTACNEQQRTTMILLCEDGSLRIYMANVENTSYWLQPSLQPSSVISIMKPVRKRKTATITARTSSQVTFPIDFFEHNQQLTDVEFGGNDLLQVYNAQQIKHRLNSTGMYVANTKPGGFTIEISNNSSTMVMTGMRIQIGTQAIERAPSYIEIFGRTMQLNLSRSRWFDFPFTREEALQADRKLSLFIGASVDPAGVTMIDAVKIYGKTKEQFGWPDEPPEDFPSASVSNICPPNLNQSNGTGESDSAAPATTSGTVLERLVVSSLEALESCFAVGPIIEKERNKHAAQELATLLLSLPAPASVQQQSKSLLASLHSSRSAYHSHKDQALLSKAVQCLNTSSKEGKDLDPEVFQRLVITARSIAVTRPNNLVHFTESKLPQMETEGADEGKEPQKQEGDGCSFITQLVNHFWKLHASKPKNAFLAPACLPGLTHIEATVNALVDIIHGYCTCELDCINTASKIYMQMLLCPDPAVSFSCKQALIRVLRPRNKRRHVTLPSSPRSNTPMGDKDDDDDDDADEKMQSSGIPDGGHIRQESQEQSEVDHGDFEMVSESMVLETAENVNNGNPSPLEALLAGAEGFPPMLDIPPDADDETMVELAIALSLQQDQQGSSSSALGLQSLGLSGQAPSSSSLDAGTLSDTTASAPASDDEGSTAATDGSTLRTSPADHGGSVGSESGGSAVDSVAGEHSVSGRSSAYGDATAEGHPAGPGSVSSSTGAISTATGHQEGDGSEGEGEGEAEGDVHTSNRLHMVRLMLLERLLQTLPQLRNVGGVRAIPYMQVILMLTTDLDGEDEKDKGALDNLLAQLIAELGMDKKDVSKKNERSALNEVHLVVMRLLSVFMSRTKSGSKSSICESSSLISSATAAALLSSGAVDYCLHVLKSLLEYWKSQQSDEEPVAASQLLKPHTTSSPPDMSPFFLRQYVKGHAADVFEAYTQLLTEMVLRLPYQIKKIADTSSRIPPPVFDHSWFYFLSEYLMIQQTPFVRRQVRKLLLFICGSKEKYRQLRDLHTLDSHVRGIKKLLEEQGIFLRASVVTASSGSALQYDTLISLMEHLKACAEIAAQRTINWQKFCIKDDSVLYFLLQVSFLVDEGVSPVLLQLLSCALCGSKVLAALAASTGSSSVASSSAPPAASSGQATTQSKSSTKKSKKEEKEKEKEGESSGSQEDQLCTALVNQLNRFADKETLIQFLRCFLLESNSSSVRWQAHCLTLHIYRNSNKAQQELLLDLMWSIWPELPAYGRKAAQFVDLLGYFSLKTAQTEKKLKEYSQKAVEILRTQNHILTNHPNSNIYNTLSGLVEFDGYYLESDPCLVCNNPEVPFCYIKLSSIKVDTRYTTTQQVVKLIGSHTISKVTVKIGDLKRTKMVRTINLYYNNRTVQAIVELKNKPARWHKAKKVQLTPGQTEVKIDLPLPIVASNLMIEFADFYENYQASTETLQCPRCSASVPANPGVCGNCGENVYQCHKCRSINYDEKDPFLCNACGFCKYARFDFMLYAKPCCAVDPIENEEDRKKAVSNINTLLDKADRVYHQLMGHRPQLENLLCKVNEAAPEKPQEDSGTAGGISSTSASVNRYILQLAQEYCGDCKNSFDELSKIIQKVFASRKELLEYDLQQREAATKSSRTSVQPTFTASQYRALSVLGCGHTSSTKCYGCASAVTEHCITLLRALATNPALRHILVSQGLIRELFDYNLRRGAAAIREEVRQLMCLLTRDNPEATQQMNDLIIGKVSTALKGHWANPDLASSLQYEMLLLTDSISKEDSCWELRLRCALSLFLMAVNIKTPVVVENITLMCLRILQKLIKPPAPTSKKNKDVPVEALTTVKPYCNEIHAQAQLWLKRDPKASYEAWKKCLPIRGVDGNGKSPSKSELHRLYLTEKYVWRWKQFLSRRGKRTTPLDLKLGHNNWLRQVLFTPATQAARQAACTIVEALATVPSRKQQVLDLLTSYLDELSVAGECAAEYLALYQKLIASCHWKVYLAARGVLPYVGNLITKEIARLLALEEATLSTDLQQGYALKSLTGLLSSFVEVESIKRHFKSRLVGTVLNGYLCLRKLVLQRTKLIDETQDMLLEMLEDMTTGTESETKAFMAVCIETAKRYNLDDYRTPVFIFERLCSIIYPEENEVTEFFVTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLEDDSGMELLVNNKIISLDLPVAEVYKKVWCATNEGEPMRIVYRMRGLLGDATEEFIESLDSTTDEEEDEEEVYRMAGVMAQCGGLQCMLNRLAGVKDFKQGRHLLTVLLKLFSYCVKVKVNRQQLVKLETNTLNVMLGTLNLALVAEQESKDSGGAAVAEQVLSIMEIILDESNAEPLSEDKGNLLLTGDKDQLVMLLDQINSTFVRSNPSVLQGLLRIIPYLSFGEVEKMQILVERFKPYCSFEKYDEDHSGDDKVFLDCFCKIAAGIKNNSNGHQLKDLILQKGITQNALDYMKKHIPSAKNLDADIWKKFLSRPALPFILRLLRGLAMQHPATQVLIGTDSITSLHKLEQVSSDEGIGTLAENLLEALREHPDVNKKIDAARRETRAEKKRMAMAMRQKALGTLGMTTNEKGQVVTKTALLKQMEELIEEPGLTCCICREGYKFQPTKVLGIYTFTKRVALEEMENKPRKQQGYSTVSHFNIVHYDCHLAAVRLARGREEWESAALQNANTKCNGLLPVWGPHVPESAFATCLARHNTYLQECTGQREPTYQLNIHDIKLLFLRFAMEQSFSADTGGGGRESNIHLIPYIIHTVLYVLNTTRATSREEKNLQGFLEQPKEKWTESAFDVDGPHYFTILALHVLPPEQWKAIRVEILRRLLVASHARAVAPGGATRLTDKAVKDYSAYRSSLLFWALVDLIYNMFKKVPTSNTEGGWSCSLAEYIRHNDMPIYEAADKALKTFQEEFMPVETFSEFLDAAGLLSEITDPESFLKDLLNSVP", "length": 5180 }, "evidence": [ { "id": "RGD:1563121", "url": "https://alliancegenome.org/gene/RGD:1563121#orthology", "database": "AGR" }, { "id": "HGNC:30313", "url": "https://alliancegenome.org/gene/HGNC:30313#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-090313-341", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-090313-341#orthology", "database": "AGR" }, { "id": "MGI:1916366", "url": "https://alliancegenome.org/gene/MGI:1916366#orthology", "database": "AGR" }, { "id": "FB:FBgn0011230", "url": "https://alliancegenome.org/gene/FB:FBgn0011230#orthology", "database": "AGR" }, { "id": "Q5T4S7", "url": "https://omabrowser.org/oma/group/Q5T4S7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q2TL32-1", "protein_name": "E3 ubiquitin-protein ligase UBR4", "gene_name": "Ubr4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATSGGEEAAAAAPAPGAPATGQDTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCSLIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPVSPELRQKEVQMNFLNQLTSVFNPRTVPSPPISPQALVEGENDEQSSTEQASAVKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYINRFQDAVVANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRTGSTSSKEEDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHFQNFQLLGAWCLLNSLFLILHLSPTALADKGKEKDPLAALRVRDILSRTKEGVGSPKLGPGKGHQGFGVLSVILANHAIKLLTSLFQDLQVEALHKGWETDGPPAVLSIMAQSTSTQRVQRLIDSVPLTNLLLTLLSTSYRKACVLQRQRKGSMSSDASASTDSNTYYEDDFSSTEEDSSQDDDSEPILGQWFEETISPSKEKAAPPPPPPPPPLESSPRVKSPSKQASGEKGNILASRKDPELFLGLASNILNFITSSMLNSRNNFIRNYLSVSLSEQHMATLASIIKEVDKDGLKGSSDEDFAAALYHFNHSLVTSDLQSPNLQNTLLQQLGVAPLSSGPWPLYIHPQGLSVLSRLLLIWQHKAGAQGDPDVPECLKVWDRFLTTMKQSALQGVVPSETEDLNIEHLQLLLLIFHSFSEKGRRAILTTLVQSIQELSVNMEVQMRSAPLILARLLLIFDYLLHQYSKAPVYLFEQVQHNLLSPPFGWASGSQDSSSSSRRANIPLYHGFKEVEENWSKHFSSDAAPQPRFYCVLSTEASEEDLNRLDSEACEVLFSKLVKYDELYSSLTALLAAGSQLDTVKRKENKNMTALEACALQYYFLILWRILGILPPSKTYMNQLAMNSPEMSECDILHTLRWSSRLRISSYVSWIKDHLIRQGMRPEHAGSLVELAASKCSSVKYDVEIVEEYFARQISSFCSIDCTTVLQLHEIPSLQSIYTLDAAVSKVQVSLDEHFSKMAAETDPHKSSEITKNLLPATLQLIDTYASFTRAYLLQNLNEEGSTEKPSQEKLHGFAAVLAIGSSRCKANTLGPTLVQNLPSSVQSVCESWNNINTNEFPNIGSWRNAFANDTIPSESYISAVQAAHLGTLCGQSLPLAASLKHALLSLVRLTGDLIVWSDEMNPAQVIRALLPLLLESSTESAAEISSNSLERILGPAESDEFLARVYEKLITGCYNILANHADPSSGLDESVLEECLQYLEKQLESSQARKAMEEFFSDGGELVQIMMATANEDLSAKFCNRVLKFFTKLFQLTEKSPNPSLLHLCGSLAQLACVEPVRLQAWLTRMTTSPPKDSDQLEVIQENRQLLQLLTTYIVRENSQVGEGVCAVLLGTLTPMATDMLANGDGTGFPELMVVMATLASAGQGAGHLQLHNAAVDWLGRCKKYLSQKNVVEKLNANVMHGKHVMVLECTCHIMSYLADVTNALSQSNGQGPSHLSVDGEERAIEVDSDWVEELAVEEEDSQAEDSDEDSLCNKLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCLALVKRTPSSGMSSTMKESAFQSEPRVSESLVRHASTSPADKAKVTISDGKVADEEKPKKSSLCRTVEGCREELQNQANFSFAPLVLDMLNFLMDAIQTNFQQASAVGSSSRAQQALSELHTVDKVVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMCVLSSPHGRRQHLAVSHEKGKITVLQLSALLKQADSSKRKLTLTRLASAPVPFTVLSLTGNPCKEDYLAVCGLKDCHVLTFSSSGSVSDHLVLHPQLATGNFIIKAVWLPGSQTELAIVTADFVKIYDLSVDALSPTFYFLLPSSKIRDVTFLFNEEGKNIIVIMSSAGYMYTQLMEEASSAQQGPFYVTNVLEINHEDLKDSNSQVAGGGVSVYYSHVLQMLFFSYSQGKSFAATVSRSTLEVLQLFPINIKSSNGGSKTSPALCQWSEVMNHPGLVCCVQQTTGVPLVVMVKPDTFLIQEIKTLPAKAKIQDMVAIRHTACNEQQRTTMILLCEDGSLRIYMANVENTSYWLQPSLQPSSVISIMKPVRKRKTATITARTSSQVTFPIDFFEHNQQLTDVEFGGNDLLQVYNAQQIKHRLNSTGMYVANTKPGGFTMEISNNSSTMVMTGMRIQIGTQAIERAPSYIEIFGRTMQLNLSRSRWFDFPFTREEALQADRKLNLFIGASVDPAGVTMIDAVKIYGKTKEQFGWPDEPPEDFPSASVSSVCPPNLNQSNSTGDSDSAAPATTSGTVLERLVVSSLEALESCFAVGPIIEKERNKHAAQELATLLLSLPAPASVQQQSKSLLASLHSSRSAYHSHKDQALLSKAVQCLNTSSKEGKDLDPEVFQRLVITARSIAVTRPNNLVHFTESKLPQMETEGAEEGKEPQKQVEGDGCSFITQLVNHFWKLHASKPKNAFLAPACLPGLTHIEATVNALVDIIHGYCTCELDCINTASKIYMQMLLCPDPAVSFSCKQALIRVLRPRNKRRHVTLPSSPRSNTPMGDKDDDDDDDADEKMQSSGIPDGGHIRQESQEQSEVDHGDFEMVSESMVLETAENVNNGNPSPLEALLAGAEGFPPMLDIPPDADDETMVELAIALSLQQDQQGSSSSALGLQSLGLSGQAPSSSSLDAGTLSDTTASGVCACNSSVTLSAPASDDEGSTAATDGSTLRTSPADHGGSVGSESGGSAVDSVAGEHSVSGRSSAYGDATAEGHPAGPGSVSSSTGAISTTTGHQEGDGSEGEGEGEAEGDVHTSNRLHMVRLMLLERLLQTLPQLRNVGGVRAIPYMQVILMLTTDLDGEDEKDKGALDNLLAQLIAELGMDKKDVSKKNERSALNEVHLVVMRLLSVFMSRTKSGSKSSICESSSLISSATAAALLSSGAVDYCLHVLKSLLEYWKGQQSEEEPVTTSQLLKPHTTSSPPDMSPFFLRQYVKGHAADVFEAYTQLLTEMVLRLPYQIKKIADTSSRIPPPVFDHSWFYFLSEYLMIQQTPFVRRQVRKLLLFICGSKEKYRQLRDLHTLDSHVRGIKKLLEEQGIFLRASVVTASSGSALQYDTLISLMEHLKACAEIAAQRTINWQKFCIKDDSVLYFLLQVSFLVDEGVSPVLLQLLSCALCGSKVLAALAASTGSSSVASSAPPAASSGQTTTQSKSSTKKSKKEKKEKEKEGESSGSQEDQLCTALVNQLNRFADKETLIQFLRCFLLESNSSSVRWQAHCLTLHIYRNSNKAQQELLLDLMWSIWPELPAYGRKAAQFVDLLGYFSLKTAQTEKKLKEYSQKAVEILRTQNHILTNHPNSNIYNTLSGLVEFDGYYLESDPCLVCNNPEVPFCYIKLSSIKVDTRYTTTQQVVKLIGSHTISKVTVKIGDLKRTKMVRTINLYYNNRTVQAIVELKNKPARWHKAKKVQLTPGQTEVKIDLPLPIVASNLMIEFADFYENYQASTETLQCPRCSASVPANPGVCGNCGENVYQCHKCRSINYDEKDPFLCNACGFCKYARFDFMLYAKPCCAVDPIENEEDRKKAVSNINTLLDKADRVYHQLMGHRPQLENLLCKVNEAAPEKPQEDSGTAGGISSTSASVNRYILQLAQEYCGDCKNSFDELSKIIQKVFASRKELLEYDLQQREAATKSSRTSVQPTFTASQYRALSVLGCGHTSSTKCYGCASAVTEHCITLLRALATNPALRHILVSQGLIRELFDYNLRRGAAAIREEVRQLMCLLTRDNPEATQQMNDLIIGKVSTALKGHWANPDLASSLQYEMLLLTDSISKEDSCWELRLRCALSLFLMAVNIKTPVVVENITLMCLRILQKLIKPPAPTSKKNKDVPVEALTTVKPYCNEIHAQAQLWLKRDPKASYEAWKKCLPIRGVDGNGKSPSKSELHRLYLTEKYVWRWKQFLSRRGKRTTPLDLKLGHNNWLRQVLFTPATQAARQAACTIVEALASVPSRKQQVLDLLTSYLDELSVAGECAAEYLALYQKLIASCHWKVYLAARGVLPYVGNLITKEIARLLALEEATLSTDLQQGYALKSLTGLLSSFVEVESIKRHFKSRLVGTVLNGYLCLRKLVLQRTKLIDETQDMLLEMLEDMTTGTESETKAFMAVCIETAKRYNLDDYRTPVFIFERLCSIIYPEENEVTEFFVTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLEDDSGMELLVNNKIISLDLPVAEVYKKVWCTTNEGEPMRIVYRMRGLLGDATEEFIESLDSTTDEEEDEEEVYRMAGVMAQCGGLQCMLNRLAGVKDFKQGRHLLTVLLKLFSYCVKVKVNRQQLVKLEMNTLNVMLGTLNLALVAEQESKDSGGAAVAEQVLSIMEIILDESNAEPLSEDKGNLLLTGDKDQLVMLLDQINSTFVRSNPSVLQGLLRIIPYLSFGEVEKMQILVERFKPYCSFDKYDEDHSGDDKVFLDCFCKIAAGIKNNSNGHQLKDLILQKGITQSALDYMKKHIPSAKNLDADIWKKFLSRPALPFILRLLRGLAMQHPATQVLIGTDSITSLHKLEQVSSDEGIGTLAENLLEALREHPDVNKKIDAARRETRAEKKRMAMAMRQKALGTLGMTTNEKGQVVTKTALLKQMEELIEEPGLTCCICREGYKFQPTKVLGIYTFTKRVALEEMENKPRKQQGYSTVSHFNIVHYDCHLAAVRLARGREEWESAALQNANTKCNGLLPVWGPHVPESAFATCLARHNTYLQECTGQREPTYQLNIHDIKLLFLRFAMEQSFSADTGGGGRESNIHLIPYIIHTVLYVLNTTRATSREEKNLQGFLEQPREKWTESAFDVDGPHYFTILALHVLPPEQWKATRVEILRRLLVASHARAVAPGGATRLTDKAVKDYSAYRSSLLFWALVDLIYNMFKKVPTSNTEGGWSCSLAEYIRHNDMPIYEAADKALKTFQEEFMPVETFSEFLDAAGLLSEITDPESFLKDLLNSVP", "length": 5194 }, "evidence": [ { "id": "RGD:1563121", "url": "https://alliancegenome.org/gene/RGD:1563121#orthology", "database": "AGR" }, { "id": "HGNC:30313", "url": "https://alliancegenome.org/gene/HGNC:30313#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-090313-341", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-090313-341#orthology", "database": "AGR" }, { "id": "MGI:1916366", "url": "https://alliancegenome.org/gene/MGI:1916366#orthology", "database": "AGR" }, { "id": "FB:FBgn0011230", "url": "https://alliancegenome.org/gene/FB:FBgn0011230#orthology", "database": "AGR" }, { "id": "Q5T4S7", "url": "https://omabrowser.org/oma/group/Q5T4S7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9SRU2-1", "protein_name": "Auxin transport protein BIG", "gene_name": "BIG", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MADDLANLCRFLFDDTAFPSLSSSASSDLFSRRLRSDDSIKRGLRSFYLLLRWGVAPIGGDDADSSGKLRFETWSDSQLQALVSISQAILLLSRSLLGTDLTLNQGLVDQLEPIVLGVIQEVMEFSLSFLEKSSFRQNDLKMEINMEILLEIASFDGSEKQYDILPDFSPAEVAELWPAFSGEHDNMDAQSLVKCTFQGGRCSNEEKPVDRLLITLMSECIESDVQAQSVVKSPFQQDCGDLNPFTRHLAVVHLRCVCRLIMVCKELVQLPNMLDEKTVDQAVLDKLSFCLRILKLLGSLSKDVQSIENDGSLLQAVASFTDAFPKLFRVFFEFTNHTATEGNIESLSLALVEGFLNLVQLIFGKSSVFQNVQACVAASIVSNLDSSVWRYDGSSCNLTPPLAYFPRSVIYTLKLIQDLKRQPYHIHDLRVLESEVTYEDVSSTVDSVYFHLRQEKIPLLKCFTVEDIMRVIFPSSSQWMDNFFHLVYFLHREGVKLRPKVERTYSSLRSNSFAEVESQISHDDEALFGNLFSEGSRSLCSIEPNDQPPVSVSSNLLLQAAKELLNFLRACILCQEWVPSIYEDGCKKLDTGHIDILLNIVGCSIEDKASDGGCMLQDEGRPGHVAFELLLNLLRSRALSDFLESYLFQQILVVENSDFNYNDKTLALLAHTLLCRPGLAGAQLRAKIYDGFVSFVTERARGICAEALSLKELTACLPSAFHIEILLMAFHLSNEAEKAKFSNLIASCLHKVDTPAGICDGPQLSSWAMLISRLLVLLHHMLLHPNTCPTSLMLDLRSKLREVRSCGSNLHVTVGDHLSSWASLVARGITDSWAEDESVSHLMSQMIDFSPHPPTFQNDVSTAKTLNLDYGDLSASLCRVLGLWKGKKAGKVEDLLVERYIFMLSSDIARINCALDSQPSLHVNYQNVDISNSVDLISTSHLLVGDINVVGRNIELRNILIGVLNQLQAAPEQVVEDLGWDYIREGAWLSLLLYFLDGGVWDYCNKNSCSEIDPFWKECTSVDAKYVAAAEGVVSYLMKTGDIAELLRMLSSLVGKYLRVYKKAFLATFSDWNHHGHSSPSLLLLKHTQFGKSLQGEYAKIGDNSLHLQCIFYLSKLDSLGDGRGSGVLWKVFWEFMVHGFPTSLQTSSAILLSCILSIRCIVLTINGLLKLGNSKEKFGVDTSVLHQLLDSIMIIKFDQVFESFHGKCEEIHQNICAVLQLPDLTELFLMKDMEGFVRDISAEQIDRSQVLEGVITKIVDVMDSLSKDSSKSDIFKFYLGVDAVSEHTREFYELQRGDLSVFIDSLDYCSLEPVNIKVLNFLVDLLSVAQSPDLRRRVQQKFIDMDLISLSGWLERRLLGSFVEEIDGKKTAKGNSLPFREAAMNFINCLVSSTNDLQTRELQNHLFEALLISLDTAFLSFDIHMSMSYFHFVLQLAREDNLMKMVLKRTIMLMEKLAAEEKLLPGLKFIFGVIGTLLSNRSPSHGESLCGKSLASYKNTATGPLVPKLSGTTKKSDTLALPVDQEGSSISLECDVTSVDEDEDDGTSDGEVASLDKEDEEDANSERYLASKVCTFTSSGSNFMEQHWYFCYTCDLTVSKGCCSVCAKVCHRGHRVVYSRSSRFFCDCGAGGVRGSSCQCLKPRKYNGNGSAPARGTNNFQSFLPLSEDADQLGESDSDVEEDGFGEENHVVLYIPKETQYKMSLLLEELGIEDRVLELFSSLLPSITSKRDSGLSKEKQVNLGKDKVLSFDTDLLQLKKAYKSGSLDLKIKADYTNSKDLKSLLANGSLVKSLLSVSVRGRLAVGEGDKVAIFDVGQLIGQATIAPINADKANVKPLSRNIVRFEIVHLSFNPVVENYLAVAGLEDCQILTLNHRGEVIDRLAVELALQGAFIRRIDWVPGSQVQLMVVTNKFVKIYDLSQDSISPTQYFTLPNDMIVDATLFVASRGRVFLLVLSEQGNLYRFELSWGGNAGATPLKEIVQIMGKDVTGKGSSVYFSPTYRLLFISYHDGSSFMGRLSSDATSLTDTSGMFEEESDCKQRVAGLHRWKELLAGSGLFICFSSVKSNAVLAVSLRGDGVCAQNLRHPTGSSSPMVGITAYKPLSKDNVHCLVLHDDGSLQIYSHVRSGVDTDSNFTAEKVKKLGSKILNNKTYAGAKPEFPLDFFERAFCITADVRLGSDAIRNGDSEGAKQSLASEDGFIESPSPVGFKISVSNPNPDIVMVGIRMHVGTTSASSIPSEVTIFQRSIKMDEGMRCWYDIPFTVAESLLADEDVVISVGPTTSGTALPRIDSLEVYGRAKDEFGWKEKMDAVLDMEARVLGHGLLLPGSSKKRALAQSASMEEQVIADGLKLLSIYYSVCRPRQEVVLSELKCKQLLETIFESDRETLLQTTACRVLQSVFPRKEIYYQVMFLPNSVKDTMRLLGVVKVTSILSSRLGILGTGGSIVEEFNAQMRAVSKVALTRKSNFSVFLEMNGSEVVDNLMQVLWGILESEPLDTPTMNNVVMSSVELIYSYAECLASQGKDTGVHSVAPAVQLLKALMLFPNESVQTSSRCVLVLAISSRLLQVPFPKQTMLTTDDLVDNVTTPSVPIRTAGGNTHVMIEEDSITSSVQYCCDGCSTVPILRRRWHCTVCPDFDLCEACYEVLDADRLPPPHTRDHPMTAIPIEVESLGADTNEIQFSADEVGISNMLPVVTSSIPQASTPSIHVLEPGESAEFSASLTDPISISASKRAVNSLILSEFLQELSGWMETVSGVQAIPVMQLFYRLSSAIGGAFMDSSKPEEISLDKLIKWLLGEINLSKPFAASTRSSLGEIVILVFMFFTLMLRSWHQPGSDGSSSKLGGSTDVHDRRIVQSSTVVATQSSLHVQERDDFASQLVRACSCLRNQEFVNYLMNILQQLVHVFKSRAANVEARGSSSGSGCGAMLTVRRDLPAGNYSPFFSDSYAKAHRADIFVDYHRLLLENVFRLVYTLVRPEKQEKMGEKEKVYRNASSKDLKLDGFQDVLCSYINNPHTAFVRRYARRLFLHLCGSKTQYYSVRDSWQFSNEVKNLYKHVEKSGGFENNVSYERSVKIVKSLSTIAEVAVARPRNWQKYCLRHGDFLSFLLNGVFHFAEESVIQTLKLLNLAFYQGKDVSSSVQKAEATEVVTGSNRSGSQSVDSKKKKKGEDGHDSGLEKLYVDMEGVVDIFSANCGDLLRQFIDFFLLEWNSSSVRTEAKSVIYGLWHHGRHSFKESLLAALLQKVRYLPAYGQNIVEYTELVSLLLDKAPENNSKQAINELVDRCLNPDVIRCFFETLHSQNELIANHPNSRIYSTLGNLVEFDGYYLESEPCVACSSPDVPYSKMKLESLKSETKFTDNRIIVKCTGSYTIQSVTMNVHDARKSKSVKVLNLYYNNRPVSDLSELKNNWSLWKRAKSCHLSFNQTELKVEFPIPITACNFMIELDSFYENLQALSLEPLQCPRCSRPVTDKHGICSNCHENAYQCRQCRNINYENLDSFLCNECGYSKYGRFEFNFMAKPSFIFDNMENDEDMKKGLAAIESESENAHKRYQQLLGFKKPLLKIVSSIGETEMDSQHKDTVQQMMASLPGPSCKINRKIALLGVLYGEKCKAAFDSVSKSVQTLQGLRRVLMSYLHQKNSNFSSGASRCVVSKTPNNCYGCATTFVTQCLEILQVLSKHPRSRKQLVAAGILSELFENNIHQGPKTARAQARAALSTFSEGDLSAVNELNNLVQKKIMYCLEHHRSMDIALATREEMLLLSEVCSLTDEFWESRLRLVFQLLFSSIKLGAKHPAISEHIILPCLKIISVACTPPKPDTAEKEQTMGKSAPAVQEKDENAAGVIKYSSESEENNLNVSQKTRDIQLVSYLEWEKGASYLDFVRRQYKASQSIRGASQKSRTHRSDFLALKYTLRWKRRSSRTSKGGLQAFELGSWVTELILSACSQSIRSEMCTLISLLAAQSSPRRYRLINLLIGLLPATLAAGESSAEYFELLFKMIETQDALLFLTVRGCLTTICKLISQEVGNIESLERSLQIDISQGFTLHKLLELLGKFLEVPNIRSRFMRDNLLSHVLEALIVIRGLIVQKTKLINDCNRRLKDLLDGLLLESSENKRQFIRACVSGLQTHAEENKGRTCLFILEQLCNLICPSKPEAVYMLILNKSHTQEEFIRGSMTKNPYSSAEIGPLMRDVKNKICQQLDLLGLLEDDYGMELLVAGNIISLDLSIAQVYELVWKKSNQSSTSLTNSALLASNAAPSRDCPPMTVTYRLQGLDGEATEPMIKELEEDREESQDPEIEFAIAGAVREYGGLEILLDMIKSLQDDFKSNQEEMVAVLDLLNHCCKIRENRRALLRLGALSLLLETARRAFSVDAMEPAEGILLIVESLTLEANESDSISAAQSALTVSNEETGTWEQAKKIVLMFLERLSHPSGLKKSNKQQRNTEMVARILPYLTYGEPAAMEALIEHFSPYLQNWSEFDQLQQRHEEDPKDDSIAQQAAKQRFTVENFVRVSESLKTSSCGERLKDIVLENGIIAVAVKHIKEIFAITGQTGFKSSKEWLLALKLPSVPLILSMLRGLSMGHLPTQTCIDEGGILTLLHALEGVSGENDIGARAENLLDTLADKEGKGDGFLGEKVRALRDATKDEMRRRALRKREELLQGLGMRQELSSDGGERIVVSQPILEGFEDVEEEEDGLACMVCREGYKLRPSDLLGVYSYSKRVNLGVGNSGSARGECVYTTVSYFNIIHFQCHQEAKRADAALKNPKKEWEGAMLRNNESLCNSLFPVKGPSVPLAQYLRYVDQYWDNLNALGRADGSRLRLLTYDIVLMLARFATGASFSADCRGGGRDSNSRFLPFMFQMARHLLDQGGPVQRTNMARSVSSYISSSSTSTATAPSSDSRPLTPGSQLSSTGTEETVQFMMVNSLLSESYESWLQHRRVFLQRGIYHTFMQHAHGRVASRAAEPTSSGGKTQDAETLTGDELLSIVKPMLVYTGMIEQLQQLFKPKKPVHIEPIKKEGTSSGVELEPWEIVMKEKLLNVKEMIGFSKELISWLDEINSATDLQEAFDIVGVLADVLSEGVTQCDQFVRSAIDKD", "length": 5098 }, "evidence": [ { "id": "Q5T4S7", "url": "https://omabrowser.org/oma/group/Q5T4S7/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VLT5-1", "protein_name": "Protein purity of essence", "gene_name": "poe", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSAHSGGTDWNSVVKALILNRTGALNKNEVVNLLKAITRCEHDFFEEESNFTQFYTAFAALAADKLMQIKTICQTQICQLHDATAVLIRFIIYRLPRVSVYETKWLLGALKMLCEGRECPASASSSMFDYNAVANVLKSCKHPESTTKSIMPSSSSSGSGASNDKESPKSEIKRSRSDLSSVILQQLIAPLEPGKMTWVPLSEEVTDCTEQILAANVEYFQEQNGVDTLLDVCVSLPILNRYRSKYMETINGGKSLYLPLTQVEATAVKSSMNHMLTDLTILSQAQALIEMQPLTPSRIERLSMCGIAALYNAVLTSIATSVLGMSQASSSQKQTASTSQGSGVGGSSGGQSNKDHDDFEDQACSIVNKALEIYSNIGHMFKTSARIHVYQNHLCYGSWLLISGIQGAMGASGSGGSSSDSASKSASKATKSGSEAGTAPTTPIARVNLFKVQQGFGELNAAIANHSIKLLSELIEDLKVEAACGQSLESTELPEPAQFDILQNYSSLERIVRVLNTATLHQLFTFLATVAYRKACTLKRASAKDRTECEPISYSDSTTYFNDSLSCSDNSEEDDSESYLGHWFKETLSPETHDDNANTSTQERAEQKSALVPKLDEPHEYLDLAADIFCFLDQFLANRHAYMQRYVKAGVSDQQMLLMANIIKDFDRDVMRNESDQGSGNAPAASAGAGTSAGASTKWQTSMIRFSGAAGRYIHNLISTSLLSEQLQSNLLQHLSISPWSTDTNTWPLQVYPSTLSVLVQILLLKPTQEKEAACLSVWHRLINTLVEGVCSSNTASDSDYEDLNIEHAQLLLFLFHSLNLMQKKSILLLTAGGVIRCAEVCRGISEDRPVKNSQIMLLSRLLLFLEYLMKHLYNAPPELLDQVRWNLFSVSSMPDTQKITDLLNCRTKLNSYCRHDIEENFRKSAGEYGSSIRPTFYSLVMGDPEISYWAQEFKLDGLAWNFILCTPDKLKYPLLVDALTDILSITDMSMYSKEKDKEASMHNLCAIQYCFTIAWKLNLGLPPSTSHVESLKAERSPNLHSLMWSIRLPLASSHYLVVSSLIKQGMYTQYAETLWTHVGDIGADIKYSLKQTILGVEAFNSQMNGNGTPRLSDLILFDSLVAHMQAVAWANKEGLKWPRKESEDAAGEQSAGTSLTSSSNDPELYSSNESIDDQKLKQDDDGKLSSDLQKYNQLVNELMVKLMNSYQLLSVIVRGQMLKQLSSSTPEKALNLIVPIVSDKPAIMLELHAAFLKLLPNEDKQLIANEWPKCLMVNDFAFNGKQHPVEPYILNVIDAHIIELTRGSNYSTLHTLKHCLKSILQLFELLLPHRTANAEVETQLKQLLISSMLDMRTDYLQGHSEHCLREILSGLTQEAQKLLLYEHMVGYCYRMLKEFAADLRQPQSAGPSGGAPLDQDRAMFNESMLFAVLKTMFKMLEKPVAVQAMRQFFKDQRSGSLTTLLLSFTGTSLPVSYARKMLQFVNRLFQLSLQADSQFQHEDLVECFSELATVDVARLKQWLGHIIYGPNVSTDVSTSEALDTTCRMLTSILQPSSSSSSNAQTPTNMATVSAMPSISDQLDPMEIEYDCGTAAGGGESNPGTGGAAANTSQILSLWQAAQPNPSEESSQACDHSDSERNGALLLSFVKSLVKDQSKASQIAPPLFQALLQLGQTLISPPQEGCDFADVLQIMITLADASPARGHVALFNTTLLWLELAKLQLPDKHLKHAENVSAQLRYLSELLQSIGFRGSRQHNPPWDDELQTDIDELYDELAEEGEQDSLLDDSDEDTLNNKLCTFSQTQKEFMNQHWYHCHTCNMINTVGVCSVCARVCHKGHDVSYAKYGNFFCDCGAKEDGSCQALSRRIGSNEVRDSAGIGSYLPSHMSLLAGKKRSSLPVGQPVLTRKDSLTNERIAVLTKLLEPYRETLQHQDQWLLVVRCILEYFDLLLPSINENCMLYSIVGCHKRATAALERLHLLEQSFQVTDQLMFATLGSQEGAFENVRMNYSGDQGQTIKHLLSSGVVRRVAFCCLSSPHGRRQQLAVSHEKGKVTILQLSALLKQADASKRKLTLTQLSSAPIACTVISLAANPCNEDCLAVCGLKECHILTFSSSGSTNEHIVVNPQLENGNYIKKAVWLPGSQTLLAVVTSDYVKIYDLAVDTYSPKYYYLVAVGKIRDCTFVYQDGNYNMLTFASSGYIYTQQLDQQSLAVHGDFYVTNTLELSHQHIKDIAGHIGGGGVSIYYSHTLQLLFYSYSCGRSFFSPLTNVSEGVKGIYHLDTNSASKSASKGPLQPLVQWTEVTGHPGLVYASMQTSNNPIILMITPERIYLQEIKAQSAKSRIMDVVGIRHAVAGVEKTTLLLLCEDGSLRIFSAQPEYTSFWLSPQVQPFGNQLYSSTLMAKGGGSGSTSKSKSNTASGKMTSRKASQQQKQPTAGGQPVFPIDFFEHCNMLADVEFGGNDLLQIYNKQKLKTRLFSTGMFVASTRSNGFTLEVINNDPNVVIVGIRVLIGTQDVQRAPQSVTILGRTIPTPVRRARWFDIPLTREEMLQSDKLLKVVFAKAPDPEHVTLLDCIEVYGKSKELVGWPDESEDVTVPGSSAPAVSSSQASSANFGEGFNCITQLDRMANHLLEVMDCALHLLGSGVPASMRQKAVKTASALLLLPTPNPVQTQARYVLATLYGTRALYHNYKDGVLLQFVNRELQSMQPKLEKLETLREIDPEAFYRLVLMVRGIANARPQSLAKICVENNYDIVPTLMGIVLELHKVTPTLDEPVNIVKRGLCQPETIVHCLVEIMYGFALADPGQVGRMTKYFIDLLKHDASVISHSAKEALILLLSPRMKRRKVAIVTPPACSTPTPSTSTMQALQAAASSAASDIIEEAAGVVVDGSVGGGGLPEPNADAEGAAVGVGGVGQQQMLNLEAFMGGGFPRLLGLPEDADDEAIMDIAIALSLQQHGGDANALQSLQQGLANLQGIRQATAMAAAVNAAANVSLGGSDDDEGSNVATDGSTLRTSPAEPAGSGGSESGGSGVESIGGTSARSSNFGDHANASPPRQGSTKDDQEQPGPSGVAGSGGVAVLSAMSSSEDNEANEDDKLSKLHDLRIAVLESIIQHLGTFDLCNGLQAIPLIQVILMLTTDLNGNNERDQQVLHDLLTALVDYVEIGKRGAAARMETKCPGNEVRLALLSLFGVLMGKTKSKQTGTTSPPHQFKDNSSFVASTTANVLSKSGAFVYALEALNTLLVHWKNVLGDPYAAGGGLASQSAQASGGASGPGVQLLKPIKHGPKPDISILIPHNYLKNYPDIFESYDGLLTEIIVRLPYQILRLSSAHPDNYDSGFCEAMTFTLCEYMMLNLNTLLRRQVRKLLMYICGSKEKFRMYRDGHSLDAHFRVVKRVCNIVSSKTGAPYNANPPMLSYDALVELTEHLRTCQEISQMRTGNWQKFCVVHEDALAMLMEIACYQLDDGVSPIIIQLLQAAVCNLPPPSGSKQAQPQPSTSSASGKLRTDREKSEDTDAYYSKFDPAQCGTFVHQIFRYACDALIIRFVRIFLLENNITQLRWQAHSFMTGLFEHANERQREKLLNIFWNLWPLVPTYGRRTAQFVDLLGYLTLSTRSITERLPEFVSRAVDVLRQQNELLCKHPNAPIYTTLESILQVNGYYLESEPCLVCNNPEVPMANIKLPSVKSDSKYTTTTMIYKLVQCHTISKLIVRIADLKRTKMVRTINVYYNNRSVQAVVELKNRPALWHKARSVSLQSAQTELKIDFPLPITACNLMIEFADFFETVSGSSENLQCPRCSAAVPAYPGVCGNCGENVFQCHKCRAINYDEKDPFLCHSCGFCKYAKFDFSMYARVCCAVDPIESAEDRVKTVSLIHSSLERADRNYRQLLTNKQMLELLIQKVAEHRSSDRMVEDNMASVHSTSQVNKIIQLLAQKYCVESRTSFEELSKIVQKVKACRSELVAYDRQQQDQPPVNPGSTTGAENPTTNRCYGCALASTEQCLTLLRAMAYNYDCRVCLYSQGLVSELAEHNLRRGTPLIQEEVRNLLVVLTKDNAEACMHLLQLVTTRVKNALMGSIPLISLEAAVHQEMTLLEVLLGQDDICWEYKLKVIFELFISNCRLPRGPVTAVLHPCLRIMQNLICPVLPGSKPNQKVATTDLCSMKMFEGNTVDYRAWLNSDRNHEYAAWSKRMPSNNQAKLKNAKDQNVAASGGSDAPPKSRREVRVAFLSEKYGKRWRERVLDKQRVIKPLVFNAKWIQPLLFNANSRFGRQLACSLLSSLSRTNERRQQALNMLTSFLKHVGEAGEASAEYLMLYKNMATEQPWLQYLVLKGVLSQISQLLAIEISKVHRMEEYSLSSDLSLGYALRQYVELLWLLLECPNIRRTYKTRMLGPVLESYLALRSLVVQRTRLIDDAQEKLLEMLEDMTSGTEEETRAFMEILIDTVEKTRMNDIKTPVFVFERLYSIIHPEEHDESEFYMTLEKDPQQEDFLQGRMLGNPYPSSEMGLGPLMRDVKNKICTDCELIALLEDDNGMELLVNNKIISLDLPVKDVYKKVWLAEGGDRDAMRIVYRMRGLLGDATEEFVETLNNKSQEQVDTEQLYRMANVLADCNGLRVMLERIGSLQRISRNRELIQVLLKLFLICVKVRRCQEVLCQPEIGAINTLLKVLQMCLQSENDSIQSAVTEQLLEIMETILSKAASDTLDSFLQFSLTFGGPEYVSALISCTDCPNVRNNPSVLRHLIRVLAALVYGNEVKMALLCEHFKDTLNFNRFDNERTPEEEFKLELFCVLTNQIEHNCIGGTLKDYIVSLGIVERSLAYITEHAPCVKPTLLRTDSDELKEFISRPSLKYILRFLTGLSNHHEATQVAISKDIIPIIHRLEQVSSDEHVGSLAENLLEALSTDSATAARVQQVRDFTRAEKKRLAMATREKQLDALGMRTNEKGQVTAKGSILQKIEKLRDETGLTCFICREGYACQPDKVLGIYTFTKRCNVEEFELKSRKTIGYTTVTHFNVVHVDCHTSAIRLTRGRDEWERASLQNANTRCNGLLPLWGPAVGEAAFSACMTRHSSYMQESTQRCDISYTSSVHDLKLLLVRFAWERSFHDDAGGGGPQSNMHFVPYLLFYSVYLLLSSRSAARDSKTLLTYLQAPPSEKWLECGYEVDGPLFMATISLSLHSRELWNKHKLAHLKRMIAVAQGRHVSPAVLCKALLAPADRQVKDYTVYKPFLMMWALVDLIYDNLFKTVSTPKEEDWPISLFDYLRKNDEALLKSTDSILQTLTEEFLPCTSFVEFCDVAGLLHLIEHPDNFIEEILAALPSTSSSN", "length": 5322 }, "evidence": [ { "id": "RGD:1563121", "url": "https://alliancegenome.org/gene/RGD:1563121#orthology", "database": "AGR" }, { "id": "HGNC:30313", "url": "https://alliancegenome.org/gene/HGNC:30313#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-090313-341", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-090313-341#orthology", "database": "AGR" }, { "id": "MGI:1916366", "url": "https://alliancegenome.org/gene/MGI:1916366#orthology", "database": "AGR" }, { "id": "FB:FBgn0011230", "url": "https://alliancegenome.org/gene/FB:FBgn0011230#orthology", "database": "AGR" }, { "id": "Q5T4S7", "url": "https://omabrowser.org/oma/group/Q5T4S7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" }, { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 10, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" }, { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" }, { "name": "specific granule membrane", "id": "GO:0035579", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035579", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" }, { "name": "tertiary granule membrane", "id": "GO:0070821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070821", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" }, { "name": "ficolin-1-rich granule membrane", "id": "GO:0101003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0101003", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 18, "go_terms": [ { "name": "response to oxidative stress", "id": "GO:0006979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006979", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" }, { "name": "negative regulation of fatty acid biosynthetic process", "id": "GO:0045717", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045717", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" }, { "name": "endosome organization", "id": "GO:0007032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007032", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" }, { "name": "positive regulation of autophagy", "id": "GO:0010508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010508", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" }, { "name": "protein K11-linked ubiquitination", "id": "GO:0070979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070979", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" }, { "name": "protein K48-linked ubiquitination", "id": "GO:0070936", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070936", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" }, { "name": "protein K27-linked ubiquitination", "id": "GO:0044314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044314", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" }, { "name": "cytoplasm protein quality control by the ubiquitin-proteasome system", "id": "GO:0071629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071629", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" }, { "name": "protein quality control for misfolded or incompletely synthesized proteins", "id": "GO:0006515", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006515", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process via the N-end rule pathway", "id": "GO:0071596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071596", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" }, { "name": "HRI-mediated signaling", "id": "GO:0140468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140468", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" }, { "name": "cytoplasm protein quality control", "id": "GO:0140455", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140455", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" }, { "name": "negative regulation of HRI-mediated signaling", "id": "GO:0141191", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141191", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" }, { "name": "protein branched polyubiquitination", "id": "GO:0141198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141198", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" }, { "name": "proteasomal protein catabolic process", "id": "GO:0010498", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010498", "evidence": [ { "database": "UniProtKB", "id": "Q5T4S7", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1253, "end_pos": 1255, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1418, "end_pos": 1420, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1804, "end_pos": 1806, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1876, "end_pos": 1878, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2248, "end_pos": 2250, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2322, "end_pos": 2324, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2343, "end_pos": 2345, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2344, "end_pos": 2346, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2378, "end_pos": 2380, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2454, "end_pos": 2456, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2457, "end_pos": 2459, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2556, "end_pos": 2558, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3420, "end_pos": 3422, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3438, "end_pos": 3440, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3596, "end_pos": 3598, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4011, "end_pos": 4013, "annotation": "n_glycosylation_sequon" }, { "start_pos": 423, "end_pos": 425, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4602, "end_pos": 4604, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4671, "end_pos": 4673, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5002, "end_pos": 5004, "annotation": "n_glycosylation_sequon" }, { "start_pos": 714, "end_pos": 716, "annotation": "n_glycosylation_sequon" }, { "start_pos": 820, "end_pos": 822, "annotation": "n_glycosylation_sequon" }, { "start_pos": 917, "end_pos": 919, "annotation": "n_glycosylation_sequon" }, { "start_pos": 990, "end_pos": 992, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-HSA-6798747", "name": "Exocytosis of tertiary granule membrane proteins", "equation": "", "summary": "Tertiary (gelatinase) granules are part of a continuum of peroxidase-negative granules formed in myelocytes, metamyelocytes, band cells and segmented neutrophils. They differ from secondary granules by having a low content of antimicrobial substances, and are more readily exocytosed (Sengelov et al. 1995). Tertiary granules are primarily a reservoir of extracellular matrix degrading enzymes and membrane receptors that are required for neutrophil extravasation and diapedesis (Faurschou & Borregaard 2003).", "cellular_location": "plasma membrane, tertiary granule membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P01111-1", "Q13393-1", "Q9Y3L5-1", "P61225-1", "O43451-2", "P00749-1", "O14672-1", "P78325-1", "Q8TF62-1", "P98196-1", "P61106-1", "Q13303-1", "P10253-1", "Q5T4S7-1", "P04839-1", "Q68CP4-1", "P23467-1" ], "evidence": [ { "id": "R-HSA-6798747", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6798747" } ] }, { "id": "R-HSA-6799350", "name": "Exocytosis of specific granule membrane proteins", "equation": "", "summary": "Secondary (specific) granules are peroxidase-negative and rich in antimicrobial substances (Joiner et al. 1989, Rorvig et al. 2012). They are more irregular and elongated in form than azurophil granules (Bainton et al. 1971). This may reflect volume adjustment in azurophil granules, which are known to proteolytically process a significant fraction of the proteins that are targeted to them, while little or no processing and therefore no increase in osmotic activity due to proteolysis has been observed in secondary granules (Borregaard & Cowland 1997). Secondary and tertiary granules have overlapping contents but can be discriminated by their intrinsic buoyant densities when centrifuged on gradient media (Kjeldsen et al. 1994).", "cellular_location": "plasma membrane, specific granule membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q13393-1", "P61225-1", "O15120-1", "Q9NPA2-1", "P62834-1", "Q7Z6P3-1", "P00749-1", "O14672-1", "P78325-1", "P43353-1", "Q8TF62-1", "P98196-1", "Q9Y2Q0-1", "Q12913-1", "Q13303-1", "O15121-1", "O75907-1", "O14975-1", "Q5T4S7-1", "Q10588-1", "P04839-1", "Q68CP4-1", "Q96AX2-1", "P23467-1", "P30519-1", "O94804-1" ], "evidence": [ { "id": "R-HSA-6799350", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6799350" } ] }, { "id": "R-HSA-6800426", "name": "Exocytosis of ficolin-rich granule membrane proteins", "equation": "", "summary": "Ficoli-1 rich granules are a relatively new fourth neutrophil granule population that is enriched in the microbial lectin ficolin-1. Ficolin-1 is present in tertiary granules, but ficolin-1 rich granules can be differentiated by having low levels of gelatinases and an elevated exocytosis propensity (Rorvig et al. 2009, 2013). The importance of these granules may be to provide rapid release of pattern recognition molecules to activate the lectin complement pathway (Rorvig et al. 2009).", "cellular_location": "plasma membrane, ficolin-1-rich granule membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P42785-1", "O43451-2", "P78325-1", "P63000-1", "P61586-1", "P10253-1", "Q5T4S7-1", "Q9Y6X5-1", "Q92932-1" ], "evidence": [ { "id": "R-HSA-6800426", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6800426" } ] }, { "id": "R-HSA-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "equation": "", "summary": "Interaction of E3 with both substrate and E2-Ub, brings them into proximity so that ubiquitin is transferred from E2 to the substrate. In most cases the transfer of ubiquitin is direct from E2 to substrate, but in a small subset of E3s, it occurs via a covalent E3-Ub thioester intermediate (Raymond et al. 2009).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9BYM8-1", "Q9H832-1", "Q969T4-1", "Q7Z7E8-1", "Q9UHC7-1", "Q96PU5-1", "Q9Y2X8-1", "Q9Y4L5-1", "Q8TDB6-1", "Q9NQ86-1", "O43255-1", "Q96BH1-1", "P49427-1", "P61081-1", "P62877-1", "Q8WVD3-1", "Q15386-1", "Q5VVX9-1", "Q86XS8-1", "O94822-1", "Q2Q1W2-1", "O60291-1", "Q5U5Q3-1", "Q96AX9-1", "Q96F44-1", "Q9NVW2-1", "O94874-1", "Q7Z3V4-1", "Q8IUQ4-1", "Q13049-1", "Q9UNE7-1", "Q16763-1", "Q86Y13-1", "Q8TBB1-1", "Q8WV44-1", "Q96PM5-1", "Q9C026-1", "O60260-1", "Q9UBS8-1", "Q9Y252-1", "P60604-1", "Q712K3-1", "Q969K3-1", "O15033-1", "O94972-1", "Q86WT6-1", "Q9H4P4-1", "Q13191-1", "Q14669-1", "Q7Z6Z7-1", "Q9UBF6-1", "O14933-1", "O95376-1", "P68036-1", "Q96LR5-1", "Q7Z419-1", "Q96J02-1", "Q9BV68-1", "Q969Q1-1", "Q9H0M0-1", "Q9HAU4-1", "Q9HCE7-1", "Q5T447-1", "Q15751-1", "Q9UII4-1", "Q05086-1", "O43164-1", "Q86XT4-1", "P78317-1", "P49459-1", "Q7Z6E9-1", "Q5VTB9-1", "Q5XPI4-1", "Q63HN8-3", "Q6ZMZ0-1", "Q9C0C9-1", "P51668-1", "P61077-1", "Q9Y508-1", "P51965-1", "P61088-1", "P62837-1", "Q6ZNA4-1", "P62253-1", "Q7Z6J8-1", "Q8IWV8-1", "Q8ND25-1", "Q9Y385-1", "Q5T4S7-1", "Q8N7E2-1", "Q8NHG8-1", "Q9HCM9-1", "P19474-1", "Q8WY64-1", "Q9Y4B6-1", "Q6Q0C0-1", "Q6UWE0-1", "Q8N6D2-1", "Q8TC41-1", "Q9NV58-1", "P61086-1", "P46934-1", "P41226-1", "P62256-1", "Q14139-1", "Q96B02-1", "Q9C037-1", "Q8IYU2-1", "Q9P2P5-1", "O95714-1", "Q15034-1", "Q8NG27-1", "Q9BWF2-1", "O94941-1", "P63146-1", "Q5GLZ8-1", "Q5U5R9-1", "Q8IVU3-1", "Q9ULT8-1", "Q7Z6J0-1", "Q9H9P5-4", "Q8IWV7-1", "Q8N2K1-1", "Q969M7-1", "O00762-1", "Q8WVN8-1" ], "evidence": [ { "id": "R-HSA-983140", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983140" } ] }, { "id": "R-HSA-983147", "name": "Release of E3 from polyubiquitinated substrate", "equation": "", "summary": "K48 polyubiquitinated substrate dissociates from E3 to become a substrate for a multicatalytic complex called the 26S proteasome.", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9BYM8-1", "Q9UHC7-1", "Q96PU5-1", "Q9Y4L5-1", "Q8TDB6-1", "Q9NQ86-1", "O43255-1", "Q96BH1-1", "P62877-1", "Q8WVD3-1", "Q15386-1", "Q86XS8-1", "O94822-1", "Q2Q1W2-1", "O60291-1", "Q5U5Q3-1", "Q96AX9-1", "Q96F44-1", "Q9NVW2-1", "O94874-1", "Q7Z3V4-1", "Q8IUQ4-1", "Q13049-1", "Q9UNE7-1", "Q86Y13-1", "Q8TBB1-1", "Q8WV44-1", "Q96PM5-1", "Q9C026-1", "O60260-1", "Q9UBS8-1", "Q9Y252-1", "Q969K3-1", "O15033-1", "O94972-1", "Q86WT6-1", "Q9H4P4-1", "Q13191-1", "Q14669-1", "Q7Z6Z7-1", "Q9UBF6-1", "O95376-1", "Q7Z419-1", "Q96J02-1", "Q9BV68-1", "Q969Q1-1", "Q9H0M0-1", "Q9HAU4-1", "Q9HCE7-1", "Q5T447-1", "Q15751-1", "Q9UII4-1", "Q05086-1", "O43164-1", "Q86XT4-1", "P78317-1", "Q7Z6E9-1", "Q5VTB9-1", "Q5XPI4-1", "Q63HN8-3", "Q6ZMZ0-1", "Q9Y508-1", "Q6ZNA4-1", "Q7Z6J8-1", "Q8IWV8-1", "Q8ND25-1", "Q5T4S7-1", "Q8N7E2-1", "Q8NHG8-1", "Q9HCM9-1", "P19474-1", "Q8WY64-1", "Q9Y4B6-1", "Q6Q0C0-1", "Q6UWE0-1", "Q8N6D2-1", "Q8TC41-1", "Q9NV58-1", "P46934-1", "Q14139-1", "Q9C037-1", "Q8IYU2-1", "Q9P2P5-1", "O95714-1", "Q15034-1", "Q8NG27-1", "Q9BWF2-1", "O94941-1", "Q5GLZ8-1", "Q5U5R9-1", "Q8IVU3-1", "Q9ULT8-1", "Q7Z6J0-1", "Q9H9P5-4", "Q8IWV7-1" ], "evidence": [ { "id": "R-HSA-983147", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983147" } ] }, { "id": "R-HSA-983156", "name": "Polyubiquitination of substrate", "equation": "", "summary": "Monoubiquitinated substrate acquires additional ubiquitin modifications in the form of multiple single attachments or a ubiquitin chain. Polyubiquitin chains added through K48 residue of ubiquitin typically targets the substrate for degradation (Raymond et al. 2009).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9BYM8-1", "Q9H832-1", "Q969T4-1", "Q7Z7E8-1", "Q9UHC7-1", "Q96PU5-1", "Q9Y2X8-1", "Q9Y4L5-1", "Q8TDB6-1", "Q9NQ86-1", "O43255-1", "Q96BH1-1", "P49427-1", "P61081-1", "P62877-1", "Q8WVD3-1", "Q15386-1", "Q5VVX9-1", "Q86XS8-1", "O94822-1", "Q2Q1W2-1", "O60291-1", "Q5U5Q3-1", "Q96AX9-1", "Q96F44-1", "Q9NVW2-1", "O94874-1", "Q7Z3V4-1", "Q8IUQ4-1", "Q13049-1", "Q9UNE7-1", "Q16763-1", "Q86Y13-1", "Q8TBB1-1", "Q8WV44-1", "Q96PM5-1", "Q9C026-1", "O60260-1", "Q9UBS8-1", "Q9Y252-1", "P60604-1", "Q712K3-1", "Q969K3-1", "O15033-1", "O94972-1", "Q86WT6-1", "Q9H4P4-1", "Q13191-1", "Q14669-1", "Q7Z6Z7-1", "Q9UBF6-1", "O14933-1", "O95376-1", "P68036-1", "Q96LR5-1", "Q7Z419-1", "Q96J02-1", "Q9BV68-1", "Q969Q1-1", "Q9H0M0-1", "Q9HAU4-1", "Q9HCE7-1", "Q5T447-1", "Q15751-1", "Q9UII4-1", "Q05086-1", "O43164-1", "Q86XT4-1", "P78317-1", "P49459-1", "Q7Z6E9-1", "Q5VTB9-1", "Q5XPI4-1", "Q63HN8-3", "Q6ZMZ0-1", "Q9C0C9-1", "P51668-1", "P61077-1", "Q9Y508-1", "P51965-1", "P61088-1", "P62837-1", "Q6ZNA4-1", "P62253-1", "Q7Z6J8-1", "Q8IWV8-1", "Q8ND25-1", "Q9Y385-1", "Q5T4S7-1", "Q8N7E2-1", "Q8NHG8-1", "Q9HCM9-1", "P19474-1", "Q8WY64-1", "Q9Y4B6-1", "Q6Q0C0-1", "Q6UWE0-1", "Q8N6D2-1", "Q8TC41-1", "Q9NV58-1", "P61086-1", "P46934-1", "P41226-1", "P62256-1", "Q14139-1", "Q96B02-1", "Q9C037-1", "Q8IYU2-1", "Q9P2P5-1", "O95714-1", "Q15034-1", "Q8NG27-1", "Q9BWF2-1", "O94941-1", "P63146-1", "Q5GLZ8-1", "Q5U5R9-1", "Q8IVU3-1", "Q9ULT8-1", "Q7Z6J0-1", "Q9H9P5-4", "Q8IWV7-1", "Q8N2K1-1", "Q969M7-1", "O00762-1", "Q8WVN8-1" ], "evidence": [ { "id": "R-HSA-983156", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983156" } ] }, { "id": "R-HSA-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "equation": "", "summary": "Ubiquitin E3 ligases confer specificity to ubiquitination by recognizing target substrates and mediating transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to substrate (Raymond et al. 2009). E3 ligases includes a large, diverse set of proteins characterized by several defining motifs which include a HECT (homologous to E6-associated C-terminus), RING (Really Interesting New Gene) and U-box domains. The E3 ligases can be multisubunit complexes rather than a single polypeptide. Presently three different kinds of E3 complexes have been described called SCF, APC, and VHL. E3 ligases binds to both substrate and an E2 thioesterified with ubiquitin (E2-Ub).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9BYM8-1", "Q9H832-1", "Q969T4-1", "Q7Z7E8-1", "Q9UHC7-1", "Q96PU5-1", "Q9Y2X8-1", "Q9Y4L5-1", "Q8TDB6-1", "Q9NQ86-1", "O43255-1", "Q96BH1-1", "P49427-1", "P61081-1", "P62877-1", "Q8WVD3-1", "Q15386-1", "Q5VVX9-1", "Q86XS8-1", "O94822-1", "Q2Q1W2-1", "O60291-1", "Q5U5Q3-1", "Q96AX9-1", "Q96F44-1", "Q9NVW2-1", "O94874-1", "Q7Z3V4-1", "Q8IUQ4-1", "Q13049-1", "Q9UNE7-1", "Q16763-1", "Q86Y13-1", "Q8TBB1-1", "Q8WV44-1", "Q96PM5-1", "Q9C026-1", "O60260-1", "Q9UBS8-1", "Q9Y252-1", "P60604-1", "Q712K3-1", "Q969K3-1", "O15033-1", "O94972-1", "Q86WT6-1", "Q9H4P4-1", "Q13191-1", "Q14669-1", "Q7Z6Z7-1", "Q9UBF6-1", "O14933-1", "O95376-1", "P68036-1", "Q96LR5-1", "Q7Z419-1", "Q96J02-1", "Q9BV68-1", "Q969Q1-1", "Q9H0M0-1", "Q9HAU4-1", "Q9HCE7-1", "Q5T447-1", "Q15751-1", "Q9UII4-1", "Q05086-1", "O43164-1", "Q86XT4-1", "P78317-1", "P49459-1", "Q7Z6E9-1", "Q5VTB9-1", "Q5XPI4-1", "Q63HN8-3", "Q6ZMZ0-1", "Q9C0C9-1", "P51668-1", "P61077-1", "Q9Y508-1", "P51965-1", "P61088-1", "P62837-1", "Q6ZNA4-1", "P62253-1", "Q7Z6J8-1", "Q8IWV8-1", "Q8ND25-1", "Q9Y385-1", "Q5T4S7-1", "Q8N7E2-1", "Q8NHG8-1", "Q9HCM9-1", "P19474-1", "Q8WY64-1", "Q9Y4B6-1", "Q6Q0C0-1", "Q6UWE0-1", "Q8N6D2-1", "Q8TC41-1", "Q9NV58-1", "P61086-1", "P46934-1", "P41226-1", "P62256-1", "Q14139-1", "Q96B02-1", "Q9C037-1", "Q8IYU2-1", "Q9P2P5-1", "O95714-1", "Q15034-1", "Q8NG27-1", "Q9BWF2-1", "O94941-1", "P63146-1", "Q5GLZ8-1", "Q5U5R9-1", "Q8IVU3-1", "Q9ULT8-1", "Q7Z6J0-1", "Q9H9P5-4", "Q8IWV7-1", "Q8N2K1-1", "Q969M7-1", "O00762-1", "Q8WVN8-1" ], "evidence": [ { "id": "R-HSA-983157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983157" } ] }, { "id": "R-HSA-9920957", "name": "NS5 binds UBR4", "equation": "", "summary": "Dengue virus (DENV) NS5 binds to the host protein UBR4, a predicted E3 ubiquitin-protein ligase. Morrison et al. 2013 show that NS5 serves as a bridge molecule between STAT2 and UBR4 and that UBR4 promotes DENV-mediated STAT2 degradation, a mechanism observed for all four DENV serotypes. This enhances the replication of DENV in an IFN-I-dependent manner in experiments using human and primate cells.", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5T4S7-1" ], "evidence": [ { "id": "R-HSA-9920957", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9920957" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "O00762", "gene_name": "UBE2C", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O00762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O00762" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "O00762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O00762" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "O00762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O00762" } ] } ] }, { "uniprot_ac": "O14672", "gene_name": "ADAM10", "activity": [ { "ec_number": "3.4.24.81", "activity": "Endopeptidase of broad specificity.", "evidence": [ { "id": "O14672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O14672" } ] }, { "ec_number": "3.4.24.81", "activity": "", "evidence": [ { "id": "O14672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O14672" } ] } ] }, { "uniprot_ac": "O14933", "gene_name": "UBE2L6", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "O14933", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O14933" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "O14933", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O14933" } ] } ] }, { "uniprot_ac": "O14975", "gene_name": "SLC27A2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O14975", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O14975" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "O14975", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O14975" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "O14975", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O14975" } ] }, { "ec_number": "6.2.1.7", "activity": "cholate + ATP + CoA = choloyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O14975", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O14975" } ] }, { "ec_number": "6.2.1.24", "activity": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA = phytanoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O14975", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O14975" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O14975", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O14975" } ] } ] }, { "uniprot_ac": "O15033", "gene_name": "AREL1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O15033", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O15033" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "O15033", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O15033" } ] } ] }, { "uniprot_ac": "O15120", "gene_name": "AGPAT2", "activity": [ { "ec_number": "2.3.1.51", "activity": "a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA.", "evidence": [ { "id": "O15120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O15120" } ] }, { "ec_number": "2.3.1.51", "activity": "", "evidence": [ { "id": "O15120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O15120" } ] } ] }, { "uniprot_ac": "O15121", "gene_name": "DEGS1", "activity": [ { "ec_number": "1.14.19.17", "activity": "an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O.", "evidence": [ { "id": "O15121", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O15121" } ] }, { "ec_number": "5.2.1.-", "activity": "", "evidence": [ { "id": "O15121", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O15121" } ] }, { "ec_number": "1.14.19.17", "activity": "", "evidence": [ { "id": "O15121", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O15121" } ] } ] }, { "uniprot_ac": "O43164", "gene_name": "PJA2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O43164", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O43164" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O43164", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O43164" } ] } ] }, { "uniprot_ac": "O43255", "gene_name": "SIAH2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O43255", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O43255" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O43255", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O43255" } ] } ] }, { "uniprot_ac": "O43451", "gene_name": "MGAM", "activity": [ { "ec_number": "3.2.1.20", "activity": "Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.", "evidence": [ { "id": "O43451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O43451" } ] } ] }, { "uniprot_ac": "O60260", "gene_name": "PRKN", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "O60260", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O60260" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "O60260", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O60260" } ] } ] }, { "uniprot_ac": "O60291", "gene_name": "MGRN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O60291", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O60291" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O60291", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O60291" } ] } ] }, { "uniprot_ac": "O75907", "gene_name": "DGAT1", "activity": [ { "ec_number": "2.3.1.20", "activity": "an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA.", "evidence": [ { "id": "O75907", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O75907" } ] }, { "ec_number": "2.3.1.20", "activity": "", "evidence": [ { "id": "O75907", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O75907" } ] }, { "ec_number": "2.3.1.76", "activity": "all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA.", "evidence": [ { "id": "O75907", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O75907" } ] } ] }, { "uniprot_ac": "O94804", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "O94804", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O94804" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O94804", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O94804" } ] } ] }, { "uniprot_ac": "O94822", "gene_name": "LTN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O94822", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O94822" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O94822", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O94822" } ] } ] }, { "uniprot_ac": "O94874", "gene_name": "UFL1", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "O94874", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O94874" } ] } ] }, { "uniprot_ac": "O94941", "gene_name": "UBOX5", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O94941", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O94941" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O94941", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O94941" } ] } ] }, { "uniprot_ac": "O94972", "gene_name": "TRIM37", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O94972", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O94972" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O94972", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O94972" } ] } ] }, { "uniprot_ac": "O95376", "gene_name": "ARIH2", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "O95376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O95376" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "O95376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O95376" } ] } ] }, { "uniprot_ac": "O95714", "gene_name": "HERC2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O95714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O95714" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "O95714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O95714" } ] } ] }, { "uniprot_ac": "P00749", "gene_name": "PLAU", "activity": [ { "ec_number": "3.4.21.73", "activity": "Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.", "evidence": [ { "id": "P00749", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00749" } ] }, { "ec_number": "3.4.21.73", "activity": "", "evidence": [ { "id": "P00749", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00749" } ] } ] }, { "uniprot_ac": "P01111", "gene_name": "NRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P01111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P01111" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P01111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P01111" } ] } ] }, { "uniprot_ac": "P04839", "gene_name": "CYBB", "activity": [ { "ec_number": "1.6.3.-", "activity": "", "evidence": [ { "id": "P04839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04839" } ] } ] }, { "uniprot_ac": "P10253", "gene_name": "GAA", "activity": [ { "ec_number": "3.2.1.20", "activity": "Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.", "evidence": [ { "id": "P10253", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10253" } ] }, { "ec_number": "3.2.1.20", "activity": "", "evidence": [ { "id": "P10253", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10253" } ] } ] }, { "uniprot_ac": "P19474", "gene_name": "TRIM21", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P19474", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19474" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "P19474", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19474" } ] } ] }, { "uniprot_ac": "P23467", "gene_name": "PTPRB", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P23467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P23467" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P23467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P23467" } ] } ] }, { "uniprot_ac": "P30519", "gene_name": "HMOX2", "activity": [ { "ec_number": "1.14.14.18", "activity": "heme b + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = biliverdin IXalpha + CO + Fe(2+) + 3 oxidized [NADPH--hemoprotein reductase] + 3 H2O + H(+).", "evidence": [ { "id": "P30519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P30519" } ] }, { "ec_number": "1.14.14.18", "activity": "", "evidence": [ { "id": "P30519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P30519" } ] } ] }, { "uniprot_ac": "P41226", "gene_name": "UBA7", "activity": [ { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "P41226", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P41226" } ] } ] }, { "uniprot_ac": "P42785", "gene_name": "PRCP", "activity": [ { "ec_number": "3.4.16.2", "activity": "Cleavage of a -Pro-|-Xaa bond to release a C-terminal amino acid.", "evidence": [ { "id": "P42785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42785" } ] }, { "ec_number": "3.4.16.2", "activity": "", "evidence": [ { "id": "P42785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42785" } ] } ] }, { "uniprot_ac": "P43353", "gene_name": "ALDH3B1", "activity": [ { "ec_number": "1.2.1.5", "activity": "an aldehyde + NADP(+) + H2O = a carboxylate + NADPH + 2 H(+).", "evidence": [ { "id": "P43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P43353" } ] }, { "ec_number": "1.2.1.28", "activity": "benzaldehyde + NAD(+) + H2O = benzoate + NADH + 2 H(+).", "evidence": [ { "id": "P43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P43353" } ] }, { "ec_number": "1.2.1.7", "activity": "benzaldehyde + NADP(+) + H2O = benzoate + NADPH + 2 H(+).", "evidence": [ { "id": "P43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P43353" } ] }, { "ec_number": "1.2.1.48", "activity": "a long-chain fatty aldehyde + NAD(+) + H2O = a long-chain fatty acid + NADH + 2 H(+).", "evidence": [ { "id": "P43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P43353" } ] }, { "ec_number": "1.2.1.5", "activity": "", "evidence": [ { "id": "P43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P43353" } ] }, { "ec_number": "1.2.1.7", "activity": "", "evidence": [ { "id": "P43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P43353" } ] }, { "ec_number": "1.2.1.28", "activity": "", "evidence": [ { "id": "P43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P43353" } ] } ] }, { "uniprot_ac": "P46934", "gene_name": "NEDD4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P46934", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46934" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "P46934", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46934" } ] } ] }, { "uniprot_ac": "P49427", "gene_name": "CDC34", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P49427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49427" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P49427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49427" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P49427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49427" } ] } ] }, { "uniprot_ac": "P49459", "gene_name": "UBE2A", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P49459", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49459" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P49459", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49459" } ] } ] }, { "uniprot_ac": "P51668", "gene_name": "UBE2D1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P51668", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P51668" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P51668", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P51668" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P51668", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P51668" } ] } ] }, { "uniprot_ac": "P51965", "gene_name": "UBE2E1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P51965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P51965" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P51965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P51965" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P51965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P51965" } ] } ] }, { "uniprot_ac": "P60604", "gene_name": "UBE2G2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P60604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P60604" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P60604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P60604" } ] } ] }, { "uniprot_ac": "P61077", "gene_name": "UBE2D3", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P61077", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61077" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61077", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61077" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61077", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61077" } ] } ] }, { "uniprot_ac": "P61081", "gene_name": "UBE2M", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "P61081", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61081" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "P61081", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61081" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61081", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61081" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61081", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61081" } ] } ] }, { "uniprot_ac": "P61086", "gene_name": "UBE2K", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61086", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61086" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61086", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61086" } ] } ] }, { "uniprot_ac": "P61088", "gene_name": "UBE2N", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61088", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61088" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61088", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61088" } ] } ] }, { "uniprot_ac": "P61106", "gene_name": "RAB14", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61106" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61106" } ] } ] }, { "uniprot_ac": "P61225", "gene_name": "RAP2B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61225", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61225" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61225", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61225" } ] } ] }, { "uniprot_ac": "P61586", "gene_name": "RHOA", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61586" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61586" } ] } ] }, { "uniprot_ac": "P62253", "gene_name": "UBE2G1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62253", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62253" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62253", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62253" } ] } ] }, { "uniprot_ac": "P62256", "gene_name": "UBE2H", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P62256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62256" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62256" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "P62256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62256" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62256" } ] } ] }, { "uniprot_ac": "P62834", "gene_name": "RAP1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62834" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62834" } ] } ] }, { "uniprot_ac": "P62837", "gene_name": "UBE2D2", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P62837", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62837" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62837", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62837" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62837", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62837" } ] } ] }, { "uniprot_ac": "P62877", "gene_name": "RBX1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P62877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62877" } ] }, { "ec_number": "2.3.2.32", "activity": "S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine.", "evidence": [ { "id": "P62877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62877" } ] }, { "ec_number": "2.3.2.32", "activity": "", "evidence": [ { "id": "P62877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62877" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "P62877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62877" } ] } ] }, { "uniprot_ac": "P63000", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P63000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63000" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P63000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63000" } ] } ] }, { "uniprot_ac": "P63146", "gene_name": "UBE2B", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P63146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63146" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P63146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63146" } ] } ] }, { "uniprot_ac": "P68036", "gene_name": "UBE2L3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P68036", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68036" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P68036", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68036" } ] } ] }, { "uniprot_ac": "P78317", "gene_name": "RNF4", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P78317", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P78317" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "P78317", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P78317" } ] } ] }, { "uniprot_ac": "P78325", "gene_name": "ADAM8", "activity": [ { "ec_number": "3.4.24.-", "activity": "", "evidence": [ { "id": "P78325", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P78325" } ] } ] }, { "uniprot_ac": "P98196", "gene_name": "ATP11A", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "P98196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P98196" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "P98196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P98196" } ] } ] }, { "uniprot_ac": "Q05086", "gene_name": "UBE3A", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q05086", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05086" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q05086", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05086" } ] } ] }, { "uniprot_ac": "Q10588", "gene_name": "BST1", "activity": [ { "ec_number": "3.2.2.6", "activity": "NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+).", "evidence": [ { "id": "Q10588", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q10588" } ] }, { "ec_number": "3.2.2.6", "activity": "", "evidence": [ { "id": "Q10588", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q10588" } ] } ] }, { "uniprot_ac": "Q12913", "gene_name": "PTPRJ", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q12913", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q12913" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q12913", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q12913" } ] } ] }, { "uniprot_ac": "Q13049", "gene_name": "TRIM32", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q13049", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q13049" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q13049", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q13049" } ] } ] }, { "uniprot_ac": "Q13191", "gene_name": "CBLB", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q13191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q13191" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q13191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q13191" } ] } ] }, { "uniprot_ac": "Q13303", "gene_name": "KCNAB2", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q13303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q13303" } ] } ] }, { "uniprot_ac": "Q13393", "gene_name": "PLD1", "activity": [ { "ec_number": "3.1.4.4", "activity": "a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + ethanolamine + H(+).", "evidence": [ { "id": "Q13393", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q13393" } ] }, { "ec_number": "3.1.4.4", "activity": "", "evidence": [ { "id": "Q13393", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q13393" } ] } ] }, { "uniprot_ac": "Q14139", "gene_name": "UBE4A", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q14139", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q14139" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q14139", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q14139" } ] } ] }, { "uniprot_ac": "Q14669", "gene_name": "TRIP12", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q14669", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q14669" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q14669", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q14669" } ] } ] }, { "uniprot_ac": "Q15034", "gene_name": "HERC3", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q15034", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q15034" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q15034", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q15034" } ] } ] }, { "uniprot_ac": "Q15386", "gene_name": "UBE3C", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q15386", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q15386" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q15386", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q15386" } ] } ] }, { "uniprot_ac": "Q15751", "gene_name": "HERC1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q15751", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q15751" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q15751", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q15751" } ] } ] }, { "uniprot_ac": "Q16763", "gene_name": "UBE2S", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q16763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q16763" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q16763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q16763" } ] } ] }, { "uniprot_ac": "Q2Q1W2", "gene_name": "TRIM71", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q2Q1W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2Q1W2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q2Q1W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2Q1W2" } ] } ] }, { "uniprot_ac": "Q5GLZ8", "gene_name": "HERC4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5GLZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5GLZ8" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q5GLZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5GLZ8" } ] } ] }, { "uniprot_ac": "Q5T447", "gene_name": "HECTD3", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5T447", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T447" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q5T447", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T447" } ] } ] }, { "uniprot_ac": "Q5T4S7", "gene_name": "UBR4", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" } ] } ] }, { "uniprot_ac": "Q5U5Q3", "gene_name": "MEX3C", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5U5Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5U5Q3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5U5Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5U5Q3" } ] } ] }, { "uniprot_ac": "Q5U5R9", "gene_name": "HECTD2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5U5R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5U5R9" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q5U5R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5U5R9" } ] } ] }, { "uniprot_ac": "Q5VTB9", "gene_name": "RNF220", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5VTB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5VTB9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5VTB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5VTB9" } ] } ] }, { "uniprot_ac": "Q5VVX9", "gene_name": "UBE2U", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q5VVX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5VVX9" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q5VVX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5VVX9" } ] } ] }, { "uniprot_ac": "Q5XPI4", "gene_name": "RNF123", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5XPI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5XPI4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5XPI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5XPI4" } ] } ] }, { "uniprot_ac": "Q63HN8", "gene_name": "RNF213", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "Q63HN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q63HN8" } ] }, { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q63HN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q63HN8" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q63HN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q63HN8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q63HN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q63HN8" } ] } ] }, { "uniprot_ac": "Q68CP4", "gene_name": "HGSNAT", "activity": [ { "ec_number": "2.3.1.78", "activity": "alpha-D-glucosaminyl-[heparan sulfate](n) + acetyl-CoA = N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n) + CoA + H(+).", "evidence": [ { "id": "Q68CP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q68CP4" } ] }, { "ec_number": "2.3.1.78", "activity": "", "evidence": [ { "id": "Q68CP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q68CP4" } ] } ] }, { "uniprot_ac": "Q6Q0C0", "gene_name": "TRAF7", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "Q6Q0C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6Q0C0" } ] }, { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6Q0C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6Q0C0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6Q0C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6Q0C0" } ] } ] }, { "uniprot_ac": "Q6UWE0", "gene_name": "LRSAM1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6UWE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6UWE0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6UWE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6UWE0" } ] } ] }, { "uniprot_ac": "Q6ZMZ0", "gene_name": "RNF19B", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q6ZMZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6ZMZ0" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q6ZMZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6ZMZ0" } ] } ] }, { "uniprot_ac": "Q6ZNA4", "gene_name": "RNF111", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6ZNA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6ZNA4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6ZNA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6ZNA4" } ] } ] }, { "uniprot_ac": "Q712K3", "gene_name": "UBE2R2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q712K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q712K3" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q712K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q712K3" } ] } ] }, { "uniprot_ac": "Q7Z3V4", "gene_name": "UBE3B", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7Z3V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7Z3V4" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q7Z3V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7Z3V4" } ] } ] }, { "uniprot_ac": "Q7Z419", "gene_name": "RNF144B", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q7Z419", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7Z419" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q7Z419", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7Z419" } ] } ] }, { "uniprot_ac": "Q7Z6E9", "gene_name": "RBBP6", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7Z6E9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7Z6E9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q7Z6E9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7Z6E9" } ] } ] }, { "uniprot_ac": "Q7Z6J0", "gene_name": "SH3RF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7Z6J0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7Z6J0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q7Z6J0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7Z6J0" } ] } ] }, { "uniprot_ac": "Q7Z6J8", "gene_name": "UBE3D", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7Z6J8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7Z6J8" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q7Z6J8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7Z6J8" } ] } ] }, { "uniprot_ac": "Q7Z6P3", "gene_name": "RAB44", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q7Z6P3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7Z6P3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q7Z6P3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7Z6P3" } ] } ] }, { "uniprot_ac": "Q7Z6Z7", "gene_name": "HUWE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7Z6Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7Z6Z7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q7Z6Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7Z6Z7" } ] } ] }, { "uniprot_ac": "Q7Z7E8", "gene_name": "UBE2Q1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q7Z7E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7Z7E8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q7Z7E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7Z7E8" } ] } ] }, { "uniprot_ac": "Q86WT6", "gene_name": "TRIM69", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q86WT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q86WT6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q86WT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q86WT6" } ] } ] }, { "uniprot_ac": "Q86XS8", "gene_name": "RNF130", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q86XS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q86XS8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q86XS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q86XS8" } ] } ] }, { "uniprot_ac": "Q86XT4", "gene_name": "TRIM50", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q86XT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q86XT4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q86XT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q86XT4" } ] } ] }, { "uniprot_ac": "Q86Y13", "gene_name": "DZIP3", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q86Y13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q86Y13" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q86Y13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q86Y13" } ] } ] }, { "uniprot_ac": "Q8IUQ4", "gene_name": "SIAH1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8IUQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8IUQ4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8IUQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8IUQ4" } ] } ] }, { "uniprot_ac": "Q8IVU3", "gene_name": "HERC6", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8IVU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8IVU3" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8IVU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8IVU3" } ] } ] }, { "uniprot_ac": "Q8IWV7", "gene_name": "UBR1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8IWV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8IWV7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8IWV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8IWV7" } ] } ] }, { "uniprot_ac": "Q8IWV8", "gene_name": "UBR2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8IWV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8IWV8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8IWV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8IWV8" } ] } ] }, { "uniprot_ac": "Q8IYU2", "gene_name": "HACE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8IYU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8IYU2" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8IYU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8IYU2" } ] } ] }, { "uniprot_ac": "Q8N2K1", "gene_name": "UBE2J2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q8N2K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8N2K1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q8N2K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8N2K1" } ] } ] }, { "uniprot_ac": "Q8N6D2", "gene_name": "RNF182", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8N6D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8N6D2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8N6D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8N6D2" } ] } ] }, { "uniprot_ac": "Q8N7E2", "gene_name": "CBLL2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8N7E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8N7E2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8N7E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8N7E2" } ] } ] }, { "uniprot_ac": "Q8ND25", "gene_name": "ZNRF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8ND25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8ND25" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8ND25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8ND25" } ] } ] }, { "uniprot_ac": "Q8NG27", "gene_name": "PJA1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8NG27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8NG27" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8NG27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8NG27" } ] } ] }, { "uniprot_ac": "Q8NHG8", "gene_name": "ZNRF2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8NHG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8NHG8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8NHG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8NHG8" } ] } ] }, { "uniprot_ac": "Q8TBB1", "gene_name": "LNX1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8TBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8TBB1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8TBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8TBB1" } ] } ] }, { "uniprot_ac": "Q8TC41", "gene_name": "RNF217", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q8TC41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8TC41" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q8TC41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8TC41" } ] } ] }, { "uniprot_ac": "Q8TDB6", "gene_name": "DTX3L", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8TDB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8TDB6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8TDB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8TDB6" } ] } ] }, { "uniprot_ac": "Q8TF62", "gene_name": "ATP8B4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "Q8TF62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8TF62" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "Q8TF62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8TF62" } ] } ] }, { "uniprot_ac": "Q8WV44", "gene_name": "TRIM41", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8WV44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8WV44" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8WV44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8WV44" } ] } ] }, { "uniprot_ac": "Q8WVD3", "gene_name": "RNF138", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8WVD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8WVD3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8WVD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8WVD3" } ] } ] }, { "uniprot_ac": "Q8WVN8", "gene_name": "UBE2Q2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q8WVN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8WVN8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q8WVN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8WVN8" } ] } ] }, { "uniprot_ac": "Q8WY64", "gene_name": "MYLIP", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8WY64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8WY64" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8WY64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8WY64" } ] } ] }, { "uniprot_ac": "Q92932", "gene_name": "PTPRN2", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "Q92932", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q92932" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q92932", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q92932" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q92932", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q92932" } ] } ] }, { "uniprot_ac": "Q969K3", "gene_name": "RNF34", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q969K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q969K3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q969K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q969K3" } ] } ] }, { "uniprot_ac": "Q969M7", "gene_name": "UBE2F", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "Q969M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q969M7" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "Q969M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q969M7" } ] } ] }, { "uniprot_ac": "Q969Q1", "gene_name": "TRIM63", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q969Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q969Q1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q969Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q969Q1" } ] } ] }, { "uniprot_ac": "Q969T4", "gene_name": "UBE2E3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q969T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q969T4" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q969T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q969T4" } ] } ] }, { "uniprot_ac": "Q96AX2", "gene_name": "RAB37", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q96AX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96AX2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q96AX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96AX2" } ] } ] }, { "uniprot_ac": "Q96AX9", "gene_name": "MIB2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q96AX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96AX9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q96AX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96AX9" } ] } ] }, { "uniprot_ac": "Q96B02", "gene_name": "UBE2W", "activity": [ { "ec_number": "2.3.2.25", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].", "evidence": [ { "id": "Q96B02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96B02" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q96B02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96B02" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q96B02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96B02" } ] }, { "ec_number": "2.3.2.25", "activity": "", "evidence": [ { "id": "Q96B02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96B02" } ] } ] }, { "uniprot_ac": "Q96BH1", "gene_name": "RNF25", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q96BH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96BH1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q96BH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96BH1" } ] } ] }, { "uniprot_ac": "Q96F44", "gene_name": "TRIM11", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q96F44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96F44" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q96F44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96F44" } ] } ] }, { "uniprot_ac": "Q96J02", "gene_name": "ITCH", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q96J02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96J02" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q96J02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96J02" } ] } ] }, { "uniprot_ac": "Q96LR5", "gene_name": "UBE2E2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q96LR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96LR5" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q96LR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96LR5" } ] } ] }, { "uniprot_ac": "Q96PM5", "gene_name": "RCHY1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q96PM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96PM5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q96PM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96PM5" } ] } ] }, { "uniprot_ac": "Q96PU5", "gene_name": "NEDD4L", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q96PU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96PU5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q96PU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96PU5" } ] }, { "ec_number": "2.3.2.36", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.", "evidence": [ { "id": "Q96PU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96PU5" } ] }, { "ec_number": "2.3.2.36", "activity": "", "evidence": [ { "id": "Q96PU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q96PU5" } ] } ] }, { "uniprot_ac": "Q9BV68", "gene_name": "RNF126", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9BV68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9BV68" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9BV68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9BV68" } ] } ] }, { "uniprot_ac": "Q9BWF2", "gene_name": "TRAIP", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9BWF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9BWF2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9BWF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9BWF2" } ] } ] }, { "uniprot_ac": "Q9BYM8", "gene_name": "RBCK1", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q9BYM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9BYM8" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q9BYM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9BYM8" } ] } ] }, { "uniprot_ac": "Q9C026", "gene_name": "TRIM9", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9C026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9C026" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9C026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9C026" } ] } ] }, { "uniprot_ac": "Q9C037", "gene_name": "TRIM4", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9C037", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9C037" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9C037", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9C037" } ] } ] }, { "uniprot_ac": "Q9C0C9", "gene_name": "UBE2O", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9C0C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9C0C9" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q9C0C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9C0C9" } ] } ] }, { "uniprot_ac": "Q9H0M0", "gene_name": "WWP1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9H0M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9H0M0" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q9H0M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9H0M0" } ] } ] }, { "uniprot_ac": "Q9H4P4", "gene_name": "RNF41", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9H4P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9H4P4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9H4P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9H4P4" } ] } ] }, { "uniprot_ac": "Q9H832", "gene_name": "UBE2Z", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q9H832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9H832" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q9H832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9H832" } ] } ] }, { "uniprot_ac": "Q9H9P5", "gene_name": "UNKL", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "Q9H9P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9H9P5" } ] } ] }, { "uniprot_ac": "Q9HAU4", "gene_name": "SMURF2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9HAU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9HAU4" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q9HAU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9HAU4" } ] } ] }, { "uniprot_ac": "Q9HCE7", "gene_name": "SMURF1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9HCE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9HCE7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q9HCE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9HCE7" } ] } ] }, { "uniprot_ac": "Q9HCM9", "gene_name": "TRIM39", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9HCM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9HCM9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9HCM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9HCM9" } ] } ] }, { "uniprot_ac": "Q9NPA2", "gene_name": "MMP25", "activity": [ { "ec_number": "3.4.24.-", "activity": "", "evidence": [ { "id": "Q9NPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9NPA2" } ] } ] }, { "uniprot_ac": "Q9NQ86", "gene_name": "TRIM36", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9NQ86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9NQ86" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9NQ86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9NQ86" } ] } ] }, { "uniprot_ac": "Q9NV58", "gene_name": "RNF19A", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q9NV58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9NV58" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q9NV58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9NV58" } ] } ] }, { "uniprot_ac": "Q9NVW2", "gene_name": "RLIM", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9NVW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9NVW2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9NVW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9NVW2" } ] } ] }, { "uniprot_ac": "Q9P2P5", "gene_name": "HECW2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9P2P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9P2P5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q9P2P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9P2P5" } ] } ] }, { "uniprot_ac": "Q9UBF6", "gene_name": "RNF7", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9UBF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9UBF6" } ] }, { "ec_number": "2.3.2.32", "activity": "S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine.", "evidence": [ { "id": "Q9UBF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9UBF6" } ] }, { "ec_number": "2.3.2.32", "activity": "", "evidence": [ { "id": "Q9UBF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9UBF6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9UBF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9UBF6" } ] } ] }, { "uniprot_ac": "Q9UBS8", "gene_name": "RNF14", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q9UBS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9UBS8" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q9UBS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9UBS8" } ] } ] }, { "uniprot_ac": "Q9UHC7", "gene_name": "MKRN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9UHC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9UHC7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9UHC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9UHC7" } ] } ] }, { "uniprot_ac": "Q9UII4", "gene_name": "HERC5", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "Q9UII4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9UII4" } ] }, { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9UII4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9UII4" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q9UII4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9UII4" } ] } ] }, { "uniprot_ac": "Q9ULT8", "gene_name": "HECTD1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9ULT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9ULT8" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q9ULT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9ULT8" } ] } ] }, { "uniprot_ac": "Q9UNE7", "gene_name": "STUB1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9UNE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9UNE7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9UNE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9UNE7" } ] } ] }, { "uniprot_ac": "Q9Y252", "gene_name": "RNF6", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9Y252", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9Y252" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9Y252", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9Y252" } ] } ] }, { "uniprot_ac": "Q9Y2Q0", "gene_name": "ATP8A1", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "Q9Y2Q0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9Y2Q0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "Q9Y2Q0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9Y2Q0" } ] } ] }, { "uniprot_ac": "Q9Y2X8", "gene_name": "UBE2D4", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q9Y2X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9Y2X8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q9Y2X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9Y2X8" } ] } ] }, { "uniprot_ac": "Q9Y385", "gene_name": "UBE2J1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q9Y385", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9Y385" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q9Y385", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9Y385" } ] } ] }, { "uniprot_ac": "Q9Y3L5", "gene_name": "RAP2C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q9Y3L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9Y3L5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q9Y3L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9Y3L5" } ] } ] }, { "uniprot_ac": "Q9Y4B6", "gene_name": "DCAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q9Y4B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9Y4B6" } ] } ] }, { "uniprot_ac": "Q9Y4L5", "gene_name": "RNF115", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9Y4L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9Y4L5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9Y4L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9Y4L5" } ] } ] }, { "uniprot_ac": "Q9Y508", "gene_name": "RNF114", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9Y508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9Y508" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9Y508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9Y508" } ] } ] }, { "uniprot_ac": "Q9Y6X5", "gene_name": "ENPP4", "activity": [ { "ec_number": "3.6.1.29", "activity": "P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = AMP + ADP + 2 H(+).", "evidence": [ { "id": "Q9Y6X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9Y6X5" } ] }, { "ec_number": "3.6.1.29", "activity": "", "evidence": [ { "id": "Q9Y6X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9Y6X5" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "8j9r", "pdb_chain": "a", "start_pos": 1660, "end_pos": 1729, "overlap": "0.01", "method": "X-Ray_Crystallography", "type": "experimental", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/8j9r.pdb", "url_external": "https://www.rcsb.org/structure/8j9r" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q5TBN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5TBN9" }, { "id": "PF13764", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13764" }, { "id": "X6R960", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/X6R960" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "E3 ubiquitin ligase UBR4 C-terminal", "eco_id": "ECO_0000259", "start_pos": 78, "end_pos": 238, "start_aa": "Val", "end_aa": "Val", "glycosite_overlap": "Ser99" }, { "evidence": [ { "id": "A0A0A0MSW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MSW0" }, { "id": "PS51157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UBR-type", "eco_id": "ECO_0000259", "start_pos": 366, "end_pos": 439, "start_aa": "Lys", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "id": "40875847", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40875847" }, { "id": "8BTL", "database": "PDB", "url": "https://www.rcsb.org/structure/8BTL" }, { "id": "PRU01388", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01388" }, { "id": "8B5W", "database": "PDB", "url": "https://www.rcsb.org/structure/8B5W" }, { "id": "9D9Z", "database": "PDB", "url": "https://www.rcsb.org/structure/9D9Z" }, { "id": "40328314", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40328314" }, { "id": "38182926", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38182926" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UZI", "eco_id": "ECO_0000269", "start_pos": 4952, "end_pos": 5182, "start_aa": "Pro", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "id": "40875847", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40875847" }, { "id": "40328314", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40328314" }, { "id": "9D9Z", "database": "PDB", "url": "https://www.rcsb.org/structure/9D9Z" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ubiquitin-like", "eco_id": "ECO_0000269", "start_pos": 4349, "end_pos": 4459, "start_aa": "Phe", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [ { "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7#function" }, { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "id": "8J9R", "database": "PDB", "url": "https://www.rcsb.org/structure/8J9R" }, { "id": "8J9Q", "database": "PDB", "url": "https://www.rcsb.org/structure/8J9Q" } ], "binding_site_uniprot": 1662, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0007744", "start_pos": 1662, "end_pos": 1662, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7#function" }, { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "id": "8J9R", "database": "PDB", "url": "https://www.rcsb.org/structure/8J9R" }, { "id": "8J9Q", "database": "PDB", "url": "https://www.rcsb.org/structure/8J9Q" } ], "binding_site_uniprot": 1679, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0007744", "start_pos": 1679, "end_pos": 1679, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7#function" }, { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "id": "8J9R", "database": "PDB", "url": "https://www.rcsb.org/structure/8J9R" }, { "id": "8J9Q", "database": "PDB", "url": "https://www.rcsb.org/structure/8J9Q" } ], "binding_site_uniprot": 1682, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0007744", "start_pos": 1682, "end_pos": 1682, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7#function" }, { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "id": "8J9R", "database": "PDB", "url": "https://www.rcsb.org/structure/8J9R" }, { "id": "8J9Q", "database": "PDB", "url": "https://www.rcsb.org/structure/8J9Q" } ], "binding_site_uniprot": 1691, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0007744", "start_pos": 1691, "end_pos": 1691, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7#function" }, { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "id": "8J9R", "database": "PDB", "url": "https://www.rcsb.org/structure/8J9R" }, { "id": "8J9Q", "database": "PDB", "url": "https://www.rcsb.org/structure/8J9Q" } ], "binding_site_uniprot": 1694, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0007744", "start_pos": 1694, "end_pos": 1694, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7#function" }, { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "id": "8J9R", "database": "PDB", "url": "https://www.rcsb.org/structure/8J9R" }, { "id": "8J9Q", "database": "PDB", "url": "https://www.rcsb.org/structure/8J9Q" } ], "binding_site_uniprot": 1698, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "3", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0007744", "start_pos": 1698, "end_pos": 1698, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7#function" }, { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "id": "8J9R", "database": "PDB", "url": "https://www.rcsb.org/structure/8J9R" }, { "id": "8J9Q", "database": "PDB", "url": "https://www.rcsb.org/structure/8J9Q" } ], "binding_site_uniprot": 1699, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0007744", "start_pos": 1699, "end_pos": 1699, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7#function" }, { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "id": "8J9R", "database": "PDB", "url": "https://www.rcsb.org/structure/8J9R" }, { "id": "8J9Q", "database": "PDB", "url": "https://www.rcsb.org/structure/8J9Q" } ], "binding_site_uniprot": 1702, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0007744", "start_pos": 1702, "end_pos": 1702, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7#function" }, { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "id": "8J9R", "database": "PDB", "url": "https://www.rcsb.org/structure/8J9R" }, { "id": "8J9Q", "database": "PDB", "url": "https://www.rcsb.org/structure/8J9Q" } ], "binding_site_uniprot": 1714, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0007744", "start_pos": 1714, "end_pos": 1714, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7#function" }, { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "id": "8J9R", "database": "PDB", "url": "https://www.rcsb.org/structure/8J9R" }, { "id": "8J9Q", "database": "PDB", "url": "https://www.rcsb.org/structure/8J9Q" } ], "binding_site_uniprot": 1716, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "3", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0007744", "start_pos": 1716, "end_pos": 1716, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7#function" }, { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "id": "8J9R", "database": "PDB", "url": "https://www.rcsb.org/structure/8J9R" }, { "id": "8J9Q", "database": "PDB", "url": "https://www.rcsb.org/structure/8J9Q" } ], "binding_site_uniprot": 1724, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "3", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0007744", "start_pos": 1724, "end_pos": 1724, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7#function" }, { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "id": "9D9Z", "database": "PDB", "url": "https://www.rcsb.org/structure/9D9Z" }, { "id": "40328314", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40328314" }, { "id": "40875847", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40875847" }, { "id": "9NWE", "database": "PDB", "url": "https://www.rcsb.org/structure/9NWE" }, { "id": "9QWU", "database": "PDB", "url": "https://www.rcsb.org/structure/9QWU" } ], "binding_site_uniprot": 3532, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "4", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000269", "start_pos": 3532, "end_pos": 3532, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7#function" }, { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "id": "9D9Z", "database": "PDB", "url": "https://www.rcsb.org/structure/9D9Z" }, { "id": "40328314", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40328314" }, { "id": "40875847", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40875847" }, { "id": "9NWE", "database": "PDB", "url": "https://www.rcsb.org/structure/9NWE" }, { "id": "9QWU", "database": "PDB", "url": "https://www.rcsb.org/structure/9QWU" } ], "binding_site_uniprot": 3535, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "4", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000269", "start_pos": 3535, "end_pos": 3535, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7#function" }, { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "id": "9NWE", "database": "PDB", "url": "https://www.rcsb.org/structure/9NWE" }, { "id": "40328314", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40328314" }, { "id": "9D9Z", "database": "PDB", "url": "https://www.rcsb.org/structure/9D9Z" } ], "binding_site_uniprot": 3660, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "5", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000269", "start_pos": 3660, "end_pos": 3660, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7#function" }, { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "id": "9NWE", "database": "PDB", "url": "https://www.rcsb.org/structure/9NWE" }, { "id": "40328314", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40328314" }, { "id": "9D9Z", "database": "PDB", "url": "https://www.rcsb.org/structure/9D9Z" } ], "binding_site_uniprot": 3663, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "5", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000269", "start_pos": 3663, "end_pos": 3663, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7#function" }, { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "id": "9NWE", "database": "PDB", "url": "https://www.rcsb.org/structure/9NWE" }, { "id": "40328314", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40328314" }, { "id": "9D9Z", "database": "PDB", "url": "https://www.rcsb.org/structure/9D9Z" } ], "binding_site_uniprot": 3674, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "5", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000269", "start_pos": 3674, "end_pos": 3674, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7#function" }, { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "id": "9NWE", "database": "PDB", "url": "https://www.rcsb.org/structure/9NWE" }, { "id": "40328314", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40328314" }, { "id": "9D9Z", "database": "PDB", "url": "https://www.rcsb.org/structure/9D9Z" } ], "binding_site_uniprot": 3677, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "5", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000269", "start_pos": 3677, "end_pos": 3677, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7#function" }, { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "id": "9NWE", "database": "PDB", "url": "https://www.rcsb.org/structure/9NWE" }, { "id": "40328314", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40328314" }, { "id": "9D9Z", "database": "PDB", "url": "https://www.rcsb.org/structure/9D9Z" } ], "binding_site_uniprot": 3684, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "6", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000269", "start_pos": 3684, "end_pos": 3684, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7#function" }, { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "id": "9NWE", "database": "PDB", "url": "https://www.rcsb.org/structure/9NWE" }, { "id": "40328314", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40328314" }, { "id": "9D9Z", "database": "PDB", "url": "https://www.rcsb.org/structure/9D9Z" } ], "binding_site_uniprot": 3687, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "6", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000269", "start_pos": 3687, "end_pos": 3687, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7#function" }, { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "id": "9NWE", "database": "PDB", "url": "https://www.rcsb.org/structure/9NWE" }, { "id": "40328314", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40328314" }, { "id": "9D9Z", "database": "PDB", "url": "https://www.rcsb.org/structure/9D9Z" } ], "binding_site_uniprot": 3700, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "6", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000269", "start_pos": 3700, "end_pos": 3700, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7#function" }, { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "id": "9NWE", "database": "PDB", "url": "https://www.rcsb.org/structure/9NWE" }, { "id": "40328314", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40328314" }, { "id": "9D9Z", "database": "PDB", "url": "https://www.rcsb.org/structure/9D9Z" } ], "binding_site_uniprot": 3703, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "6", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000269", "start_pos": 3703, "end_pos": 3703, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7#function" }, { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "id": "9D9Z", "database": "PDB", "url": "https://www.rcsb.org/structure/9D9Z" }, { "id": "40328314", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40328314" }, { "id": "40875847", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40875847" }, { "id": "9NWE", "database": "PDB", "url": "https://www.rcsb.org/structure/9NWE" }, { "id": "9QWU", "database": "PDB", "url": "https://www.rcsb.org/structure/9QWU" } ], "binding_site_uniprot": 3872, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "4", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000269", "start_pos": 3872, "end_pos": 3872, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7#function" }, { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "id": "9D9Z", "database": "PDB", "url": "https://www.rcsb.org/structure/9D9Z" }, { "id": "40328314", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40328314" }, { "id": "40875847", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40875847" }, { "id": "9NWE", "database": "PDB", "url": "https://www.rcsb.org/structure/9NWE" }, { "id": "9QWU", "database": "PDB", "url": "https://www.rcsb.org/structure/9QWU" } ], "binding_site_uniprot": 3875, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "4", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000269", "start_pos": 3875, "end_pos": 3875, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7#function" }, { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "id": "8B5W", "database": "PDB", "url": "https://www.rcsb.org/structure/8B5W" }, { "id": "PRU01388", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01388" }, { "id": "38182926", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38182926" }, { "id": "8BTL", "database": "PDB", "url": "https://www.rcsb.org/structure/8BTL" } ], "binding_site_uniprot": 4838, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "7", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000269", "start_pos": 4838, "end_pos": 4838, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7#function" }, { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "id": "8B5W", "database": "PDB", "url": "https://www.rcsb.org/structure/8B5W" }, { "id": "PRU01388", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01388" }, { "id": "38182926", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38182926" }, { "id": "8BTL", "database": "PDB", "url": "https://www.rcsb.org/structure/8BTL" } ], "binding_site_uniprot": 4841, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "7", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000269", "start_pos": 4841, "end_pos": 4841, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7#function" }, { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "id": "8B5W", "database": "PDB", "url": "https://www.rcsb.org/structure/8B5W" }, { "id": "PRU01388", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01388" }, { "id": "38182926", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38182926" }, { "id": "8BTL", "database": "PDB", "url": "https://www.rcsb.org/structure/8BTL" } ], "binding_site_uniprot": 4887, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "7", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000269", "start_pos": 4887, "end_pos": 4887, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7#function" }, { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5T4S7" }, { "id": "8B5W", "database": "PDB", "url": "https://www.rcsb.org/structure/8B5W" }, { "id": "PRU01388", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01388" }, { "id": "38182926", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38182926" }, { "id": "8BTL", "database": "PDB", "url": "https://www.rcsb.org/structure/8BTL" } ], "binding_site_uniprot": 4890, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "7", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000269", "start_pos": 4890, "end_pos": 4890, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.27", "ec_name": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "2.3.2.27", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.27" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.agr", "label": "AGR Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 2248, 2378 ], "o_linked_sites": [ 18, 99, 625, 627, 870, 1343, 3479, 3843 ], "snv_sites": [ 12, 17, 18, 23, 31, 35, 61, 65, 68, 74, 77, 79, 87, 91, 93, 94, 98, 102, 103, 105, 112, 130, 131, 132, 139, 142, 145, 154, 157, 158, 161, 168, 178, 179, 190, 198, 199, 209, 210, 214, 215, 220, 224, 225, 233, 235, 236, 245, 246, 250, 253, 258, 260, 264, 268, 271, 272, 276, 281, 284, 285, 286, 294, 296, 298, 300, 305, 308, 310, 312, 319, 323, 325, 328, 329, 331, 334, 345, 348, 359, 361, 364, 365, 374, 379, 380, 382, 383, 390, 393, 396, 397, 399, 400, 404, 407, 410, 412, 414, 416, 418, 424, 428, 429, 435, 438, 441, 443, 448, 450, 451, 453, 457, 461, 462, 465, 469, 472, 477, 485, 489, 497, 504, 506, 507, 509, 510, 515, 518, 523, 526, 535, 536, 541, 543, 544, 554, 555, 559, 560, 561, 562, 563, 565, 570, 573, 574, 576, 577, 579, 584, 585, 590, 600, 601, 608, 612, 613, 615, 616, 625, 627, 641, 643, 645, 653, 658, 660, 661, 666, 669, 675, 677, 683, 696, 697, 699, 704, 727, 731, 734, 735, 736, 742, 748, 759, 766, 776, 785, 790, 794, 795, 796, 801, 802, 819, 822, 826, 827, 831, 840, 841, 842, 844, 849, 852, 857, 873, 875, 887, 888, 891, 893, 901, 902, 916, 918, 919, 920, 925, 926, 929, 932, 936, 937, 942, 943, 944, 947, 950, 951, 954, 956, 957, 970, 978, 984, 989, 990, 994, 995, 999, 1001, 1003, 1004, 1011, 1014, 1028, 1033, 1040, 1041, 1042, 1044, 1056, 1061, 1066, 1070, 1079, 1095, 1097, 1098, 1105, 1107, 1111, 1116, 1120, 1123, 1126, 1129, 1134, 1137, 1141, 1143, 1146, 1149, 1153, 1162, 1167, 1169, 1171, 1172, 1183, 1184, 1191, 1192, 1193, 1196, 1206, 1224, 1227, 1233, 1237, 1239, 1242, 1246, 1248, 1254, 1257, 1258, 1266, 1272, 1275, 1278, 1281, 1285, 1287, 1292, 1295, 1296, 1297, 1298, 1303, 1308, 1309, 1316, 1317, 1322, 1329, 1330, 1331, 1333, 1334, 1336, 1339, 1341, 1343, 1349, 1351, 1352, 1356, 1358, 1370, 1372, 1374, 1375, 1380, 1390, 1392, 1394, 1403, 1407, 1409, 1410, 1416, 1417, 1418, 1423, 1426, 1427, 1430, 1432, 1441, 1444, 1445, 1448, 1463, 1470, 1471, 1473, 1483, 1489, 1492, 1494, 1497, 1501, 1505, 1510, 1513, 1518, 1524, 1530, 1542, 1547, 1548, 1554, 1557, 1558, 1559, 1562, 1565, 1574, 1582, 1583, 1587, 1591, 1593, 1597, 1598, 1600, 1604, 1607, 1609, 1611, 1619, 1622, 1625, 1628, 1629, 1634, 1639, 1641, 1642, 1643, 1644, 1647, 1648, 1653, 1659, 1663, 1665, 1666, 1670, 1674, 1682, 1686, 1695, 1699, 1703, 1705, 1707, 1721, 1725, 1732, 1735, 1737, 1744, 1745, 1746, 1748, 1751, 1752, 1757, 1760, 1769, 1771, 1776, 1777, 1779, 1780, 1781, 1790, 1792, 1793, 1803, 1806, 1808, 1810, 1812, 1813, 1815, 1818, 1824, 1831, 1832, 1833, 1841, 1845, 1850, 1861, 1871, 1874, 1875, 1879, 1883, 1886, 1895, 1896, 1898, 1904, 1905, 1906, 1908, 1909, 1923, 1926, 1927, 1934, 1935, 1936, 1944, 1950, 1955, 1956, 1962, 1966, 1971, 1976, 1984, 1987, 1994, 1997, 1998, 2007, 2009, 2017, 2020, 2022, 2025, 2027, 2042, 2044, 2045, 2046, 2048, 2051, 2057, 2058, 2066, 2069, 2071, 2072, 2073, 2075, 2082, 2083, 2092, 2095, 2097, 2105, 2107, 2112, 2113, 2116, 2118, 2120, 2123, 2137, 2140, 2144, 2154, 2158, 2161, 2164, 2169, 2172, 2174, 2181, 2182, 2184, 2187, 2196, 2198, 2200, 2204, 2209, 2212, 2218, 2236, 2240, 2245, 2246, 2249, 2250, 2255, 2267, 2269, 2270, 2272, 2274, 2275, 2280, 2281, 2297, 2307, 2309, 2320, 2321, 2323, 2329, 2330, 2331, 2333, 2344, 2347, 2352, 2353, 2358, 2361, 2363, 2366, 2375, 2378, 2381, 2383, 2386, 2388, 2398, 2401, 2403, 2410, 2413, 2417, 2422, 2440, 2446, 2452, 2453, 2457, 2458, 2461, 2462, 2463, 2465, 2467, 2469, 2473, 2476, 2482, 2486, 2487, 2488, 2489, 2492, 2494, 2502, 2503, 2505, 2506, 2507, 2510, 2514, 2519, 2520, 2525, 2530, 2535, 2536, 2539, 2561, 2564, 2566, 2568, 2569, 2581, 2584, 2585, 2586, 2588, 2592, 2603, 2607, 2610, 2620, 2624, 2630, 2642, 2649, 2651, 2652, 2653, 2655, 2665, 2669, 2688, 2690, 2692, 2694, 2696, 2703, 2712, 2715, 2719, 2721, 2722, 2725, 2729, 2736, 2738, 2739, 2742, 2745, 2747, 2749, 2762, 2763, 2764, 2772, 2773, 2774, 2777, 2779, 2785, 2786, 2787, 2789, 2792, 2795, 2797, 2801, 2805, 2807, 2808, 2813, 2821, 2825, 2830, 2832, 2837, 2843, 2846, 2848, 2852, 2865, 2866, 2872, 2874, 2875, 2876, 2883, 2886, 2892, 2894, 2898, 2908, 2910, 2914, 2915, 2927, 2928, 2929, 2930, 2932, 2949, 2953, 2956, 2959, 2963, 2965, 2971, 2974, 2979, 2980, 2983, 2989, 2991, 2992, 2993, 2995, 2996, 2999, 3001, 3010, 3013, 3014, 3015, 3019, 3026, 3040, 3041, 3045, 3053, 3065, 3068, 3086, 3087, 3097, 3100, 3104, 3113, 3115, 3116, 3119, 3120, 3121, 3129, 3138, 3140, 3142, 3144, 3155, 3158, 3160, 3168, 3170, 3177, 3178, 3179, 3180, 3182, 3183, 3185, 3189, 3196, 3199, 3204, 3207, 3208, 3211, 3218, 3220, 3222, 3225, 3230, 3231, 3237, 3238, 3241, 3248, 3252, 3256, 3257, 3258, 3263, 3266, 3273, 3283, 3284, 3286, 3291, 3297, 3302, 3304, 3306, 3310, 3313, 3314, 3316, 3325, 3326, 3340, 3344, 3346, 3347, 3348, 3350, 3357, 3363, 3370, 3373, 3375, 3376, 3378, 3385, 3390, 3397, 3402, 3407, 3411, 3413, 3420, 3421, 3425, 3429, 3430, 3434, 3438, 3440, 3442, 3453, 3462, 3463, 3470, 3473, 3475, 3487, 3488, 3492, 3498, 3502, 3505, 3510, 3514, 3522, 3531, 3538, 3540, 3544, 3549, 3550, 3554, 3555, 3560, 3561, 3566, 3568, 3571, 3580, 3583, 3588, 3592, 3593, 3596, 3597, 3599, 3603, 3604, 3609, 3610, 3611, 3617, 3626, 3632, 3633, 3641, 3643, 3647, 3652, 3656, 3660, 3661, 3662, 3666, 3668, 3672, 3683, 3693, 3697, 3709, 3710, 3715, 3718, 3729, 3732, 3740, 3747, 3748, 3751, 3757, 3765, 3769, 3770, 3776, 3784, 3785, 3786, 3794, 3795, 3798, 3802, 3809, 3810, 3824, 3825, 3832, 3843, 3844, 3848, 3854, 3857, 3858, 3861, 3865, 3866, 3868, 3870, 3883, 3888, 3892, 3911, 3914, 3915, 3916, 3919, 3922, 3923, 3924, 3926, 3939, 3945, 3960, 3962, 3971, 3976, 3978, 3995, 3998, 4006, 4013, 4014, 4019, 4026, 4029, 4033, 4034, 4036, 4038, 4041, 4042, 4045, 4048, 4049, 4052, 4053, 4057, 4064, 4072, 4076, 4079, 4081, 4084, 4087, 4088, 4093, 4111, 4115, 4116, 4117, 4118, 4128, 4130, 4142, 4144, 4149, 4156, 4159, 4163, 4169, 4180, 4182, 4185, 4189, 4191, 4193, 4202, 4210, 4213, 4216, 4219, 4226, 4231, 4234, 4240, 4241, 4243, 4246, 4251, 4253, 4254, 4256, 4261, 4274, 4275, 4277, 4280, 4282, 4283, 4285, 4288, 4289, 4293, 4299, 4301, 4310, 4313, 4314, 4319, 4322, 4325, 4328, 4334, 4337, 4341, 4342, 4345, 4349, 4360, 4364, 4365, 4367, 4369, 4371, 4375, 4378, 4381, 4383, 4384, 4387, 4395, 4410, 4413, 4423, 4430, 4434, 4442, 4443, 4445, 4450, 4456, 4462, 4467, 4468, 4476, 4480, 4481, 4493, 4494, 4496, 4502, 4507, 4510, 4511, 4534, 4535, 4540, 4542, 4554, 4555, 4562, 4566, 4567, 4570, 4573, 4577, 4592, 4597, 4601, 4607, 4610, 4613, 4615, 4618, 4619, 4621, 4623, 4624, 4626, 4627, 4628, 4631, 4635, 4640, 4651, 4655, 4660, 4674, 4675, 4679, 4683, 4684, 4688, 4697, 4698, 4700, 4701, 4703, 4710, 4712, 4715, 4716, 4721, 4730, 4733, 4734, 4735, 4739, 4746, 4757, 4761, 4771, 4772, 4777, 4778, 4779, 4785, 4791, 4792, 4794, 4795, 4796, 4804, 4818, 4822, 4829, 4834, 4848, 4859, 4861, 4867, 4871, 4880, 4889, 4890, 4891, 4894, 4895, 4901, 4903, 4904, 4906, 4907, 4912, 4913, 4918, 4920, 4921, 4926, 4933, 4937, 4942, 4944, 4950, 4958, 4961, 4964, 4967, 4969, 4975, 4980, 4983, 4985, 4991, 5003, 5009, 5010, 5012, 5013, 5015, 5019, 5023, 5027, 5033, 5037, 5042, 5045, 5047, 5051, 5053, 5060, 5062, 5070, 5074, 5075, 5085, 5086, 5089, 5091, 5092, 5093, 5098, 5100, 5108, 5111, 5116, 5124, 5128, 5131, 5133, 5144, 5150, 5154, 5156, 5157, 5162, 5163, 5170, 5174, 5177, 5182 ], "sites_with_glycoeffect": [ 3915, 1001, 1028, 1028, 1042, 1042, 1070, 1079, 1105, 1107, 1120, 1123, 1129, 1134, 1162, 1169, 1171, 1191, 1206, 1224, 1237, 1239, 1246, 1258, 1272, 1275, 1285, 1287, 1295, 1322, 1329, 1330, 1331, 1333, 1343, 1351, 1370, 1375, 1375, 1390, 1418, 1432, 1441, 1444, 1444, 1444, 1444, 1445, 1473, 1497, 1530, 1565, 157, 1583, 1607, 1611, 1619, 1622, 1634, 1647, 1663, 1665, 168, 1705, 1721, 1737, 1752, 1760, 1769, 1771, 178, 1803, 1806, 1824, 18, 18, 1904, 1927, 1934, 1935, 1936, 1956, 1966, 1966, 1987, 198, 1998, 199, 2027, 2044, 2048, 2066, 2069, 2071, 2092, 2112, 2137, 2140, 2154, 2158, 215, 2161, 2161, 2174, 2184, 2196, 2204, 2249, 2250, 225, 2274, 2281, 2323, 2331, 2344, 2358, 235, 2366, 2378, 2446, 2457, 2462, 2462, 2469, 2473, 2482, 2482, 2488, 2503, 2505, 2505, 2514, 2520, 2525, 2535, 2539, 253, 2592, 2620, 264, 2651, 2669, 2694, 2694, 2696, 2715, 2719, 2722, 2725, 2773, 2785, 2786, 2787, 2787, 281, 2832, 2852, 2874, 2892, 2910, 2915, 2932, 2965, 2999, 3026, 3040, 3045, 305, 3068, 3097, 3104, 312, 312, 3144, 3177, 3179, 3189, 3220, 323, 3257, 3257, 3266, 328, 3302, 3340, 3344, 3346, 3347, 3348, 3363, 3370, 3370, 3402, 3407, 3420, 3421, 3438, 3440, 3442, 3453, 345, 3505, 3510, 3538, 3544, 3544, 3549, 3554, 3568, 3593, 3596, 3609, 364, 365, 3666, 3740, 3770, 3785, 3795, 3795, 3795, 3810, 3824, 3843, 3854, 3870, 3892, 393, 3976, 3978, 3995, 4013, 4048, 4052, 4088, 4116, 4117, 4169, 4191, 4193, 4240, 4246, 4253, 4253, 4285, 4337, 4413, 4450, 4462, 451, 4573, 457, 4610, 4610, 4624, 4674, 4688, 4701, 4715, 4859, 485, 4871, 4906, 4913, 4942, 4942, 4975, 4985, 5003, 5037, 5086, 5092, 5093, 5144, 5154, 5156, 515, 536, 541, 544, 555, 559, 561, 563, 570, 573, 576, 577, 585, 600, 61, 625, 627, 627, 658, 660, 661, 669, 675, 677, 748, 74, 801, 822, 831, 841, 875, 87, 893, 901, 919, 937, 950, 978, 990 ], "glycation_sites": [], "phosphorylation_sites": [ 178, 181, 212, 360, 363, 364, 365, 370, 473, 619, 620, 625, 905, 1077, 1078, 1123, 1402, 1572, 1647, 1652, 1747, 1754, 1760, 1761, 1762, 1763, 1878, 1904, 1927, 2278, 2279, 2715, 2718, 2719, 2722, 2724, 2884, 2944, 2952, 3175, 3177, 3179, 3432, 4270 ], "sequon_annotation_sites": [ { "start_pos": 1253, "end_pos": 1255 }, { "start_pos": 1418, "end_pos": 1420 }, { "start_pos": 1804, "end_pos": 1806 }, { "start_pos": 1876, "end_pos": 1878 }, { "start_pos": 2248, "end_pos": 2250 }, { "start_pos": 2322, "end_pos": 2324 }, { "start_pos": 2343, "end_pos": 2345 }, { "start_pos": 2344, "end_pos": 2346 }, { "start_pos": 2378, "end_pos": 2380 }, { "start_pos": 2454, "end_pos": 2456 }, { "start_pos": 2457, "end_pos": 2459 }, { "start_pos": 2556, "end_pos": 2558 }, { "start_pos": 3420, "end_pos": 3422 }, { "start_pos": 3438, "end_pos": 3440 }, { "start_pos": 3596, "end_pos": 3598 }, { "start_pos": 4011, "end_pos": 4013 }, { "start_pos": 423, "end_pos": 425 }, { "start_pos": 4602, "end_pos": 4604 }, { "start_pos": 4671, "end_pos": 4673 }, { "start_pos": 5002, "end_pos": 5004 }, { "start_pos": 714, "end_pos": 716 }, { "start_pos": 820, "end_pos": 822 }, { "start_pos": 917, "end_pos": 919 }, { "start_pos": 990, "end_pos": 992 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 11 }, { "field": "total_sites", "count": 10 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 8 }, { "field": "n_linked_glycan_sites", "count": 2 }, { "field": "o_linked_glycan_sites", "count": 7 }, { "field": "n_linked_glycans", "count": 2 }, { "field": "o_linked_glycans", "count": 2 }, { "field": "exact_sites", "count": 10 }, { "field": "exact_o_linked_sites", "count": 8 }, { "field": "exact_o_linked_glycan_sites", "count": 7 }, { "field": "exact_o_linked_glycans", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "exact_n_linked_glycan_sites", "count": 2 }, { "field": "exact_n_linked_glycans", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 10 }, { "field": "total_sites", "count": 9 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 7 }, { "field": "n_linked_glycan_sites", "count": 2 }, { "field": "o_linked_glycan_sites", "count": 7 }, { "field": "n_linked_glycans", "count": 2 }, { "field": "o_linked_glycans", "count": 2 }, { "field": "exact_sites", "count": 9 }, { "field": "exact_o_linked_sites", "count": 7 }, { "field": "exact_o_linked_glycan_sites", "count": 7 }, { "field": "exact_o_linked_glycans", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "exact_n_linked_glycan_sites", "count": 2 }, { "field": "exact_n_linked_glycans", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 44 }, { "field": "total_sites", "count": 44 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1434 }, { "field": "total_sites", "count": 1248 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1355 }, { "field": "total_sites", "count": 1187 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 79 }, { "field": "total_sites", "count": 70 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 181 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } } ]