[ { "uniprot_canonical_ac": "Q15303-1", "uniprot_ac": "Q15303", "uniprot_id": "ERBB4_HUMAN", "mass": { "chemical_mass": 146808.0, "monoisotopic_mass": 146808.0 }, "refseq": { "ac": "NP_001036064", "name": "receptor tyrosine-protein kinase erbB-4 isoform JM-a/CYT-2 precursor", "summary": "This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036064" }, "gene_names": [ { "name": "ERBB4", "type": "recommended", "evidence": [ { "id": "Q15303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ] }, { "name": "ALS19", "type": "synonym", "evidence": [ { "id": "NP_001036064", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036064" } ] }, { "name": "ERBB4", "type": "synonym", "evidence": [ { "id": "NP_001036064", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036064" } ] }, { "name": "HER4", "type": "synonym", "evidence": [ { "id": "NP_001036064", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036064" }, { "id": "Q15303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ] }, { "name": "p180erbB4", "type": "synonym", "evidence": [ { "id": "NP_001036064", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036064" } ] } ], "protein_names": [ { "name": "Receptor tyrosine-protein kinase erbB-4", "type": "recommended", "evidence": [ { "id": "Q15303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q15303/entry#names_and_taxonomy" } ] }, { "name": "2.7.10.1", "type": "synonym", "evidence": [ { "id": "Q15303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q15303/entry#names_and_taxonomy" } ] }, { "name": "Proto-oncogene-like protein c-ErbB-4", "type": "synonym", "evidence": [ { "id": "Q15303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q15303/entry#names_and_taxonomy" } ] }, { "name": "Tyrosine kinase-type cell surface receptor HER4", "type": "synonym", "evidence": [ { "id": "Q15303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q15303/entry#names_and_taxonomy" } ] }, { "name": "avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4", "type": "synonym", "evidence": [ { "id": "NP_001036064", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036064" } ] }, { "name": "human epidermal growth factor receptor 4", "type": "synonym", "evidence": [ { "id": "NP_001036064", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036064" } ] }, { "name": "p180erbB4", "type": "synonym", "evidence": [ { "id": "Q15303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q15303/entry#names_and_taxonomy" } ] }, { "name": "proto-oncogene-like protein c-ErbB-4", "type": "synonym", "evidence": [ { "id": "NP_001036064", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036064" } ] }, { "name": "receptor tyrosine-protein kinase erbB-4 isoform JM-a/CYT-2 precursor", "type": "synonym", "evidence": [ { "id": "NP_001036064", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036064" } ] }, { "name": "receptor tyrosine-protein kinase erbB-4", "type": "synonym", "evidence": [ { "id": "NP_001036064", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036064" } ] }, { "name": "s80HER4", "type": "synonym", "evidence": [ { "id": "Q15303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q15303/entry#names_and_taxonomy" } ] }, { "name": "tyrosine kinase-type cell surface receptor HER4", "type": "synonym", "evidence": [ { "id": "NP_001036064", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036064" } ] }, { "name": "v-erb-a erythroblastic leukemia viral oncogene homolog 4", "type": "synonym", "evidence": [ { "id": "NP_001036064", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036064" } ] }, { "name": "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4", "type": "synonym", "evidence": [ { "id": "NP_001036064", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036064" } ] } ], "function": [ { "annotation": "ErbB4 affects Th1/Th17 cell differentiation and promotes psoriasis progression. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001036064", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036064" }, { "database": "PubMed", "id": "38063127", "url": "https://glygen.org/publication/PubMed/38063127" } ] }, { "annotation": "Genetic variants of ERBB4 gene and risk of gestational diabetes mellitus: a susceptibility and diagnostic nomogram study. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001036064", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036064" }, { "database": "PubMed", "id": "38149095", "url": "https://glygen.org/publication/PubMed/38149095" } ] }, { "annotation": "HER4 is a high-affinity dimerization partner for all EGFR/HER/ErbB family proteins.", "evidence": [ { "database": "RefSeq", "id": "NP_001036064", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036064" }, { "database": "PubMed", "id": "39276020", "url": "https://glygen.org/publication/PubMed/39276020" } ] }, { "annotation": "Neuregulin-1 and ALS19 (ERBB4): at the crossroads of amyotrophic lateral sclerosis and cancer. Review article Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001036064", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036064" }, { "database": "PubMed", "id": "38369520", "url": "https://glygen.org/publication/PubMed/38369520" } ] }, { "annotation": "The role and mechanism of NRG1/ErbB4 in inducing the differentiation of induced pluripotent stem cells into cardiomyocytes. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001036064", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036064" }, { "database": "PubMed", "id": "39407109", "url": "https://glygen.org/publication/PubMed/39407109" } ] }, { "annotation": "This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001036064", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036064" } ] }, { "annotation": "Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis.", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303#function" }, { "database": "PubMed", "id": "9168115", "url": "https://glygen.org/publication/PubMed/9168115" }, { "database": "PubMed", "id": "10358079", "url": "https://glygen.org/publication/PubMed/10358079" }, { "database": "PubMed", "id": "10722704", "url": "https://glygen.org/publication/PubMed/10722704" }, { "database": "PubMed", "id": "10348342", "url": "https://glygen.org/publication/PubMed/10348342" }, { "database": "PubMed", "id": "9135143", "url": "https://glygen.org/publication/PubMed/9135143" }, { "database": "PubMed", "id": "9334263", "url": "https://glygen.org/publication/PubMed/9334263" }, { "database": "PubMed", "id": "11178955", "url": "https://glygen.org/publication/PubMed/11178955" }, { "database": "PubMed", "id": "15534001", "url": "https://glygen.org/publication/PubMed/15534001" }, { "database": "PubMed", "id": "10353604", "url": "https://glygen.org/publication/PubMed/10353604" }, { "database": "PubMed", "id": "8383326", "url": "https://glygen.org/publication/PubMed/8383326" }, { "database": "PubMed", "id": "17486069", "url": "https://glygen.org/publication/PubMed/17486069" }, { "database": "PubMed", "id": "8617750", "url": "https://glygen.org/publication/PubMed/8617750" }, { "database": "PubMed", "id": "20858735", "url": "https://glygen.org/publication/PubMed/20858735" }, { "database": "PubMed", "id": "11390655", "url": "https://glygen.org/publication/PubMed/11390655" }, { "database": "PubMed", "id": "12807903", "url": "https://glygen.org/publication/PubMed/12807903" }, { "database": "PubMed", "id": "16778220", "url": "https://glygen.org/publication/PubMed/16778220" }, { "database": "PubMed", "id": "10867024", "url": "https://glygen.org/publication/PubMed/10867024" }, { "database": "PubMed", "id": "17638867", "url": "https://glygen.org/publication/PubMed/17638867" }, { "database": "PubMed", "id": "19098003", "url": "https://glygen.org/publication/PubMed/19098003" }, { "database": "PubMed", "id": "16251361", "url": "https://glygen.org/publication/PubMed/16251361" }, { "database": "PubMed", "id": "16837552", "url": "https://glygen.org/publication/PubMed/16837552" }, { "database": "PubMed", "id": "15746097", "url": "https://glygen.org/publication/PubMed/15746097" } ] } ], "disease": [ { "disease_id": "DOID:0050700", "recommended_name": { "id": "DOID:0050700", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0050700", "name": "cardiomyopathy", "description": "A heart disease and a myopathy that is characterized by deterioration of the function of the heart muscle." }, "synonyms": [ { "id": "DOID:0050700", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0050700", "name": "Cardiomyopathies", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "0050700", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050700" } ] }, { "disease_id": "DOID:0050865", "recommended_name": { "id": "DOID:0050865", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0050865", "name": "tongue squamous cell carcinoma", "description": "A head and neck squamous cell carcinoma that is located_in the tongue." }, "synonyms": [], "unlinked_id_list": [], "evidence": [ { "id": "0050865", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050865" } ] }, { "disease_id": "DOID:0050866", "recommended_name": { "id": "DOID:0050866", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0050866", "name": "oral squamous cell carcinoma", "description": "An oral cavity cancer that has_material_basis_in squamous cells." }, "synonyms": [ { "id": "DOID:0050866", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0050866", "name": "mouth squamous cell carcinoma", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "0050866", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050866" } ] }, { "disease_id": "DOID:0051061", "recommended_name": { "id": "DOID:0051061", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0051061", "name": "stroke", "description": "A cerebrovascular disease that is characterized by disruption of blood flow to the brain resulting in damage to brain cells due to a lack of oxygen." }, "synonyms": [], "unlinked_id_list": [], "evidence": [ { "id": "0051061", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0051061" } ] }, { "disease_id": "DOID:0060074", "recommended_name": { "id": "DOID:0060074", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0060074", "name": "ductal carcinoma in situ", "description": "A breast carcinoma in situ that is characterized by being non-invasive, not having spread outside of the duct into the surrounding breast tissue, has_material_basis_in abnormally proliferating cells, derives_from epithelial cells." }, "synonyms": [], "unlinked_id_list": [], "evidence": [ { "id": "0060074", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060074" } ] }, { "disease_id": "DOID:0060210", "recommended_name": { "id": "DOID:0060210", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0060210", "name": "amyotrophic lateral sclerosis type 19", "description": "An amyotrophic lateral sclerosis that has_material_basis_in mutation in the ERBB4 gene on chromosome 2." }, "synonyms": [ { "id": "DOID:0060210", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0060210", "name": "ALS19", "description": "" }, { "id": "DOID:0060210", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0060210", "name": "amyotrophic lateral sclerosis 19", "description": "" }, { "id": "MONDO:0014223", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014223", "name": "amyotrophic lateral sclerosis type 19", "description": "Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the ERBB4 gene." }, { "id": "MONDO:0014223", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014223", "name": "ALS19", "description": "" }, { "id": "MONDO:0014223", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014223", "name": "ERBB4 amyotrophic lateral sclerosis", "description": "" }, { "id": "MONDO:0014223", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014223", "name": "amyotrophic lateral sclerosis 19", "description": "" }, { "id": "MONDO:0014223", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014223", "name": "amyotrophic lateral sclerosis caused by mutation in ERBB4", "description": "" }, { "id": "MONDO:0014223", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014223", "name": "amyotrophic lateral sclerosis type 19", "description": "" }, { "id": "MIM:615515", "resource": "MIM", "url": "https://www.omim.org/entry/615515", "name": "Amyotrophic lateral sclerosis 19", "description": "Amyotrophic lateral sclerosis 19" } ], "unlinked_id_list": [], "evidence": [ { "id": "615515", "database": "MIM", "url": "https://www.omim.org/entry/615515" }, { "id": "0060210", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060210" } ] }, { "disease_id": "DOID:10155", "recommended_name": { "id": "DOID:10155", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10155", "name": "intestinal cancer", "description": "A gastrointestinal system cancer that is located_in the intestine." }, "synonyms": [ { "id": "DOID:10155", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10155", "name": "malignant intestinal tumors", "description": "" }, { "id": "DOID:10155", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10155", "name": "malignant neoplasm of intestine", "description": "" } ], "unlinked_id_list": [ "DOID:10154", "DOID:4907", "DOID:5672" ], "evidence": [ { "id": "10155", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10155" } ] }, { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] }, { "disease_id": "DOID:10376", "recommended_name": { "id": "DOID:10376", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10376", "name": "amblyopia", "description": "An eye disease that is characterized by poor vision in one eye resulting from the brain failing to process inputs from one eye and over time favors the other eye. The weaker or lazy eye often wanders inward or outward." }, "synonyms": [ { "id": "DOID:10376", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10376", "name": "lazy eye", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "10376", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10376" } ] }, { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "11054", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11054" } ] }, { "disease_id": "DOID:13949", "recommended_name": { "id": "DOID:13949", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:13949", "name": "interstitial cystitis", "description": "" }, "synonyms": [ { "id": "DOID:13949", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:13949", "name": "ulcerative cystitis", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "13949", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13949" } ] }, { "disease_id": "DOID:1574", "recommended_name": { "id": "DOID:1574", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1574", "name": "alcohol use disorder", "description": "A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences." }, "synonyms": [ { "id": "DOID:1574", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1574", "name": "Ethanol abuse", "description": "" }, { "id": "DOID:1574", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1574", "name": "alcohol abuse", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "1574", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1574" } ] }, { "disease_id": "DOID:162", "recommended_name": { "id": "DOID:162", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:162", "name": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis." }, "synonyms": [ { "id": "DOID:162", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:162", "name": "malignant neoplasm", "description": "" }, { "id": "DOID:162", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:162", "name": "malignant tumor", "description": "" }, { "id": "DOID:162", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:162", "name": "primary cancer", "description": "" } ], "unlinked_id_list": [ "DOID:193", "DOID:7757", "DOID:2151", "DOID:3316", "DOID:370", "DOID:706", "DOID:5604", "DOID:184", "DOID:2599", "DOID:4706", "DOID:2174", "DOID:4015", "DOID:4203", "DOID:170", "DOID:10154", "DOID:3017", "DOID:5166", "DOID:1795", "DOID:3149", "DOID:8527", "DOID:0050938", "DOID:3093", "DOID:0060122", "DOID:201", "DOID:3303", "DOID:3350", "DOID:176", "DOID:2595", "DOID:5093", "DOID:0070003", "DOID:0080355", "DOID:368", "DOID:0080524", "DOID:9460", "DOID:0080639", "DOID:0050619", "DOID:0080638", "DOID:4907", "DOID:1325", "DOID:688", "DOID:771", "DOID:0060073", "DOID:672", "DOID:5772", "DOID:4645", "DOID:0080879", "DOID:4765", "DOID:1357", "DOID:5032", "DOID:0060083", "DOID:0050743", "DOID:4045", "DOID:5672", "DOID:3675", "DOID:5662", "DOID:192", "DOID:4043", "DOID:0060116", "DOID:0080364", "DOID:0060100", "DOID:3095", "DOID:0080525", "DOID:3541", "DOID:4230", "DOID:1294", "DOID:0050615", "DOID:0050687", "DOID:3953", "DOID:5158", "DOID:1039", "DOID:3973", "DOID:8858", "DOID:0060119", "DOID:3111", "DOID:60004", "DOID:5467", "DOID:1036", "DOID:2706", "DOID:3856", "DOID:3112", "DOID:3479", "DOID:2815", "DOID:660", "DOID:120", "DOID:2021", "DOID:4114", "DOID:0081452", "DOID:4455", "DOID:3451", "DOID:175", "DOID:4931", "DOID:3277", "DOID:1659", "DOID:4960", "DOID:3001", "DOID:2621", "DOID:1542", "DOID:3419", "DOID:6536", "DOID:3850" ], "evidence": [ { "id": "162", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:162" } ] }, { "disease_id": "DOID:1824", "recommended_name": { "id": "DOID:1824", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1824", "name": "status epilepticus", "description": "" }, "synonyms": [ { "id": "DOID:1824", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1824", "name": "Grand mal status", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "1824", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1824" } ] }, { "disease_id": "DOID:1826", "recommended_name": { "id": "DOID:1826", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1826", "name": "epilepsy", "description": "A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions." }, "synonyms": [ { "id": "DOID:1826", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1826", "name": "epilepsy syndrome", "description": "" }, { "id": "DOID:1826", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1826", "name": "epileptic syndrome", "description": "" } ], "unlinked_id_list": [ "DOID:3331", "DOID:0050702", "DOID:0060172", "DOID:0050706", "DOID:0050705", "DOID:0050703", "DOID:0050701", "DOID:0060169" ], "evidence": [ { "id": "1826", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1826" } ] }, { "disease_id": "DOID:2671", "recommended_name": { "id": "DOID:2671", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2671", "name": "transitional cell carcinoma", "description": "A carcinoma that derives_from transitional epithelial cells." }, "synonyms": [ { "id": "DOID:2671", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2671", "name": "transitional carcinoma", "description": "" }, { "id": "DOID:2671", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2671", "name": "transitional cell tumor", "description": "" }, { "id": "DOID:2671", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2671", "name": "urothelial cell carcinoma", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "2671", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2671" } ] }, { "disease_id": "DOID:2876", "recommended_name": { "id": "DOID:2876", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2876", "name": "laryngeal squamous cell carcinoma", "description": "A laryngeal carcinoma that has_material_basis_in squamous cells." }, "synonyms": [ { "id": "DOID:2876", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2876", "name": "Epidermoid carcinoma of the Larynx", "description": "" }, { "id": "DOID:2876", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2876", "name": "squamous cell carcinoma of larynx", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "2876", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2876" } ] }, { "disease_id": "DOID:305", "recommended_name": { "id": "DOID:305", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:305", "name": "carcinoma", "description": "A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells." }, "synonyms": [ { "id": "DOID:305", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:305", "name": "epithelial cancer", "description": "" }, { "id": "DOID:305", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:305", "name": "epithelioma", "description": "" }, { "id": "DOID:305", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:305", "name": "malignant Epithelioma", "description": "" } ], "unlinked_id_list": [ "DOID:0080524", "DOID:0080525", "DOID:1542", "DOID:3112", "DOID:3973", "DOID:4455", "DOID:4931", "DOID:5662", "DOID:2599", "DOID:1294", "DOID:2151", "DOID:4015", "DOID:3149", "DOID:4907", "DOID:3451" ], "evidence": [ { "id": "305", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:305" } ] }, { "disease_id": "DOID:3312", "recommended_name": { "id": "DOID:3312", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3312", "name": "bipolar disorder", "description": "A mood disorder that involves alternating periods of mania and depression." }, "synonyms": [ { "id": "DOID:3312", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3312", "name": "Manic Bipolar Affective disorder", "description": "" }, { "id": "DOID:3312", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3312", "name": "Manic Depressive disorder", "description": "" }, { "id": "DOID:3312", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3312", "name": "Manic bipolar I disorder", "description": "" }, { "id": "DOID:3312", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3312", "name": "bipolar depression", "description": "" }, { "id": "DOID:3312", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3312", "name": "bipolar disorder manic phase", "description": "" }, { "id": "DOID:3312", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3312", "name": "manic depression", "description": "" }, { "id": "DOID:3312", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3312", "name": "manic disorder", "description": "" }, { "id": "DOID:3312", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3312", "name": "mixed bipolar disorder", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "3312", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3312" } ] }, { "disease_id": "DOID:3748", "recommended_name": { "id": "DOID:3748", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3748", "name": "esophagus squamous cell carcinoma", "description": "An esophageal carcinoma that derives_from epithelial squamous cells located_in the esophagus." }, "synonyms": [ { "id": "DOID:3748", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3748", "name": "SCC of esophagus", "description": "" }, { "id": "DOID:3748", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3748", "name": "SCC of oesophagus", "description": "" }, { "id": "DOID:3748", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3748", "name": "oesophagus squamous cell carcinoma", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "3748", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3748" } ] }, { "disease_id": "DOID:3910", "recommended_name": { "id": "DOID:3910", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3910", "name": "lung adenocarcinoma", "description": "A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin." }, "synonyms": [ { "id": "DOID:3910", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3910", "name": "bronchogenic lung adenocarcinoma", "description": "" }, { "id": "DOID:3910", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3910", "name": "nonsmall cell adenocarcinoma", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "3910", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3910" } ] }, { "disease_id": "DOID:4306", "recommended_name": { "id": "DOID:4306", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4306", "name": "radiculopathy", "description": "A peripheral nervous system disease that is characterized by the pinching of a nerve root in the spine and has symptoms of pain, weakness, numbness and tingling." }, "synonyms": [ { "id": "DOID:4306", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4306", "name": "pinched nerve", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "4306", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4306" } ] }, { "disease_id": "DOID:4362", "recommended_name": { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "cervical cancer", "description": "A female reproductive organ cancer that is located_in the cervix." }, "synonyms": [ { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "cervical neoplasm", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "cervix cancer", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "cervix uteri cancer", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "neoplasm of uterine cervix", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "tumor of the Cervix Uteri", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4362", "name": "uterine cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical cancer", "description": "A primary or metastatic malignant neoplasm involving the cervix." }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "tumor of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "tumour of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "uterine 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cervix neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "uterine cervix cancer", "description": "" }, { "id": "MIM:603956", "resource": "MIM", "url": "https://www.omim.org/entry/603956", "name": "Cervical cancer", "description": "Cervical cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "4362", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4362" } ] }, { "disease_id": "DOID:4450", "recommended_name": { "id": "DOID:4450", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4450", "name": "renal cell carcinoma", "description": "A renal carcinoma that has_material_basis_in the lining of the proximal convoluted renal tubule of the kidney." }, "synonyms": [ { "id": "DOID:4450", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4450", "name": "RCC", "description": "" }, { "id": "DOID:4450", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4450", "name": "adenocarcinoma of kidney", "description": "" }, { "id": "DOID:4450", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4450", "name": "hypernephroma", "description": "" }, { "id": "MONDO:0010456", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010456", "name": "renal cell carcinoma, Xp11-associated", "description": "" }, { "id": "MONDO:0010456", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010456", "name": "renal cell carcinoma, Xp11-associated", "description": "" }, { "id": "MONDO:0010456", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010456", "name": "renal cell carcinoma, papillary, 1", "description": "" }, { "id": "MONDO:0010456", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010456", "name": "RCCX1", "description": "" }, { "id": "MIM:300854", "resource": "MIM", "url": "https://www.omim.org/entry/300854", "name": "Renal cell carcinoma Xp11-associated", "description": "Renal cell carcinoma Xp11-associated" } ], "unlinked_id_list": [ "DOID:4455" ], "evidence": [ { "id": "4450", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4450" } ] }, { "disease_id": "DOID:5419", "recommended_name": { "id": "DOID:5419", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5419", "name": "schizophrenia", "description": "A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness." }, "synonyms": [ { "id": "DOID:5419", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5419", "name": "schizophrenia-1", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia", "description": "A major psychotic disorder characterized by abnormalities in the perception or expression of reality. It affects the cognitive and psychomotor functions. Common clinical signs and symptoms include delusions, hallucinations, disorganized thinking, and retreat from reality." }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia 12", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia (disease)", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "SCZD", "description": "" }, { "id": "MIM:181500", "resource": "MIM", "url": "https://www.omim.org/entry/181500", "name": "Schizophrenia", "description": "Schizophrenia" } ], "unlinked_id_list": [], "evidence": [ { "id": "5419", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5419" } ] }, { "disease_id": "DOID:5517", "recommended_name": { "id": "DOID:5517", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5517", "name": "stomach carcinoma", "description": "A stomach cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:5517", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5517", "name": "cancer of the stomach", "description": "" }, { "id": "DOID:5517", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5517", "name": "carcinoma of stomach", "description": "" }, { "id": "DOID:5517", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5517", "name": "gastric carcinoma", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "5517", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5517" } ] }, { "disease_id": "DOID:5520", "recommended_name": { "id": "DOID:5520", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5520", "name": "head and neck squamous cell carcinoma", "description": "A head and neck carcinoma that has_material_basis_in squamous cells that line the moist, mucosal surfaces inside the head and neck." }, "synonyms": [ { "id": "DOID:5520", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5520", "name": "carcinoma of the head and neck", "description": "" }, { "id": "DOID:5520", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5520", "name": "squamous cell carcinoma of the head and neck", "description": "" }, { "id": "DOID:5520", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5520", "name": "squamous cell carcinomas of head and neck", "description": "" }, { "id": "MONDO:0010150", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010150", "name": "head and neck squamous cell carcinoma", "description": "A squamous cell carcinoma that arises from any of the following anatomic sites: lip and oral cavity, nasal cavity, paranasal sinuses, pharynx, larynx, and salivary glands." }, { "id": "MONDO:0010150", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010150", "name": "HNSCC", "description": "" }, { "id": "MONDO:0010150", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010150", "name": "SCCHN", "description": "" }, { "id": "MONDO:0010150", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010150", "name": "craniocervical region squamous cell carcinoma", "description": "" }, { "id": "MONDO:0010150", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010150", "name": "head and neck squamous cell carcinoma", "description": "" }, { "id": "MONDO:0010150", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010150", "name": "squamous cell carcinoma of head and neck", "description": "" }, { "id": "MONDO:0010150", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010150", "name": "squamous cell carcinoma of the head and neck", "description": "" }, { "id": "MONDO:0010150", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010150", "name": "squamous cell carcinoma, head and neck, somatic", "description": "" }, { "id": "MONDO:0010150", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010150", "name": "carcinoma of the head and neck", "description": "" }, { "id": "MONDO:0010150", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010150", "name": "squamous cell carcinoma, head and neck", "description": "" }, { "id": "MIM:275355", "resource": "MIM", "url": "https://www.omim.org/entry/275355", "name": "Squamous cell carcinoma of the head and neck", "description": "Squamous cell carcinoma of the head and neck" } ], "unlinked_id_list": [], "evidence": [ { "id": "5520", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5520" }, { "id": "5520", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5520" }, { "id": "5520", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5520" } ] }, { "disease_id": "DOID:571", "recommended_name": { "id": "DOID:571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:571", "name": "median neuropathy", "description": "" }, "synonyms": [], "unlinked_id_list": [], "evidence": [ { "id": "571", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:571" } ] }, { "disease_id": "DOID:5844", "recommended_name": { "id": "DOID:5844", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5844", "name": "myocardial infarction", "description": "A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia." }, "synonyms": [ { "id": "DOID:5844", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5844", "name": "Myocardial infarct", "description": "" }, { "id": "DOID:5844", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5844", "name": "heart attack", "description": "" }, { "id": "MONDO:0012058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012058", "name": "myocardial infarction, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012058", "name": "myocardial infarction, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012058", "name": "myocardial infarction, susceptibility to, type 2", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "5844", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5844" } ] }, { "disease_id": "DOID:6000", "recommended_name": { "id": "DOID:6000", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:6000", "name": "congestive heart failure", "description": "A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body." }, "synonyms": [ { "id": "DOID:6000", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:6000", "name": "CHF", "description": "" }, { "id": "DOID:6000", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:6000", "name": "Cardiac Failure Congestive", "description": "" }, { "id": "DOID:6000", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:6000", "name": "Congestive heart disease", "description": "" }, { "id": "DOID:6000", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:6000", "name": "Weak heart", "description": "" } ], "unlinked_id_list": [ "DOID:12326" ], "evidence": [ { "id": "6000", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:6000" } ] }, { "disease_id": "DOID:684", "recommended_name": { "id": "DOID:684", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:684", "name": "hepatocellular carcinoma", "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver." }, "synonyms": [ { "id": "DOID:684", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:684", "name": "Hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation." }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "HCC", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "cancer, hepatocellular", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma, hepatocellular, malignant", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular adenocarcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, childhood type, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell cancer (hepatocellular carcinoma)", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult primary hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation." }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "HCC", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "cancer, hepatocellular", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma, hepatocellular, malignant", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular adenocarcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, childhood type, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell cancer (hepatocellular carcinoma)", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult primary hepatocellular carcinoma", "description": "" }, { "id": "MIM:114550", "resource": "MIM", "url": "https://www.omim.org/entry/114550", "name": "Hepatocellular carcinoma", "description": "Hepatocellular carcinoma" } ], "unlinked_id_list": [], "evidence": [ { "id": "684", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:684" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 1000, "end_pos": 1000, "sequence_org": "D", "sequence_mut": "A", "comment": "Abolishes APC/C-mediated degradation; when associated with A-992 and A-995.", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" }, { "database": "PubMed", "id": "17638867", "url": "https://glygen.org/publication/PubMed/17638867" } ] }, { "start_pos": 1035, "end_pos": 1035, "sequence_org": "Y", "sequence_mut": "A", "comment": "No effect on interaction with WWOX. Abolishes interaction with WWOX; when associated with A-1301.", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" }, { "database": "PubMed", "id": "16061658", "url": "https://glygen.org/publication/PubMed/16061658" } ] }, { "start_pos": 1056, "end_pos": 1056, "sequence_org": "Y", "sequence_mut": "A", "comment": "Abolishes interaction with NEDD4 and impairs ubiquitination. Promotes nuclear translocation of ERBB4 intracellular domain E4ICD1.", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" }, { "database": "PubMed", "id": "19561640", "url": "https://glygen.org/publication/PubMed/19561640" } ] }, { "start_pos": 1056, "end_pos": 1056, "sequence_org": "Y", "sequence_mut": "F", "comment": "Abolishes interaction with WWP1; when associated with F-1301.", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" }, { "database": "PubMed", "id": "19561640", "url": "https://glygen.org/publication/PubMed/19561640" } ] }, { "start_pos": 1301, "end_pos": 1301, "sequence_org": "Y", "sequence_mut": "A", "comment": "Abolishes interaction with NEDD4 and impairs ubiquitination.", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" }, { "database": "PubMed", "id": "19561640", "url": "https://glygen.org/publication/PubMed/19561640" }, { "database": "PubMed", "id": "12807903", "url": "https://glygen.org/publication/PubMed/12807903" }, { "database": "PubMed", "id": "16061658", "url": "https://glygen.org/publication/PubMed/16061658" } ] }, { "start_pos": 1301, "end_pos": 1301, "sequence_org": "Y", "sequence_mut": "A", "comment": "No effect on interaction with WWOX. Abolishes interaction with WWOX; when associated with A-1035. Loss of interaction with YAP1 and stimulation of transcription.", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" }, { "database": "PubMed", "id": "19561640", "url": "https://glygen.org/publication/PubMed/19561640" }, { "database": "PubMed", "id": "12807903", "url": "https://glygen.org/publication/PubMed/12807903" }, { "database": "PubMed", "id": "16061658", "url": "https://glygen.org/publication/PubMed/16061658" } ] }, { "start_pos": 1301, "end_pos": 1301, "sequence_org": "Y", "sequence_mut": "F", "comment": "Abolishes interaction with WWP1; when associated with F-1056.", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" }, { "database": "PubMed", "id": "19561640", "url": "https://glygen.org/publication/PubMed/19561640" }, { "database": "PubMed", "id": "12807903", "url": "https://glygen.org/publication/PubMed/12807903" }, { "database": "PubMed", "id": "16061658", "url": "https://glygen.org/publication/PubMed/16061658" } ] }, { "start_pos": 646, "end_pos": 646, "sequence_org": "Q", "sequence_mut": "C", "comment": "Constitutively activated kinase.", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" }, { "database": "PubMed", "id": "17120616", "url": "https://glygen.org/publication/PubMed/17120616" } ] }, { "start_pos": 675, "end_pos": 675, "sequence_org": "V", "sequence_mut": "A", "comment": "Abolishes proteolytic processing and nuclear localization.", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" }, { "database": "PubMed", "id": "17638867", "url": "https://glygen.org/publication/PubMed/17638867" }, { "database": "PubMed", "id": "15746097", "url": "https://glygen.org/publication/PubMed/15746097" } ] }, { "start_pos": 681, "end_pos": 684, "sequence_org": "KKKR", "sequence_mut": "EIMG", "comment": "Abolishes nuclear localization of the ERBB4 intracellular domain.", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" }, { "database": "PubMed", "id": "15534001", "url": "https://glygen.org/publication/PubMed/15534001" } ] }, { "start_pos": 710, "end_pos": 710, "sequence_org": "L", "sequence_mut": "N", "comment": "Strongly reduced autophosphorylation.", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" }, { "database": "PubMed", "id": "18287036", "url": "https://glygen.org/publication/PubMed/18287036" } ] }, { "start_pos": 721, "end_pos": 721, "sequence_org": "V", "sequence_mut": "I", "comment": "No effect on kinase activity.", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" }, { "database": "PubMed", "id": "19098003", "url": "https://glygen.org/publication/PubMed/19098003" } ] }, { "start_pos": 751, "end_pos": 751, "sequence_org": "K", "sequence_mut": "R", "comment": "Abolishes kinase activity. Abolishes phosphorylation, proteolytic processing and nuclear localization.", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" }, { "database": "PubMed", "id": "17486069", "url": "https://glygen.org/publication/PubMed/17486069" }, { "database": "PubMed", "id": "11390655", "url": "https://glygen.org/publication/PubMed/11390655" }, { "database": "PubMed", "id": "17638867", "url": "https://glygen.org/publication/PubMed/17638867" } ] }, { "start_pos": 766, "end_pos": 766, "sequence_org": "M", "sequence_mut": "R", "comment": "Strongly reduced autophosphorylation.", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" }, { "database": "PubMed", "id": "18287036", "url": "https://glygen.org/publication/PubMed/18287036" } ] }, { "start_pos": 773, "end_pos": 773, "sequence_org": "A", "sequence_mut": "S", "comment": "No effect on kinase activity.", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" }, { "database": "PubMed", "id": "19098003", "url": "https://glygen.org/publication/PubMed/19098003" } ] }, { "start_pos": 782, "end_pos": 782, "sequence_org": "R", "sequence_mut": "Q", "comment": "No effect on kinase activity.", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" }, { "database": "PubMed", "id": "19098003", "url": "https://glygen.org/publication/PubMed/19098003" } ] }, { "start_pos": 810, "end_pos": 810, "sequence_org": "E", "sequence_mut": "K", "comment": "No effect on kinase activity.", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" }, { "database": "PubMed", "id": "19098003", "url": "https://glygen.org/publication/PubMed/19098003" } ] }, { "start_pos": 843, "end_pos": 843, "sequence_org": "D", "sequence_mut": "N", "comment": "Loss of kinase activity.", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" }, { "database": "PubMed", "id": "16978839", "url": "https://glygen.org/publication/PubMed/16978839" } ] }, { "start_pos": 854, "end_pos": 854, "sequence_org": "P", "sequence_mut": "Q", "comment": "No effect on kinase activity.", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" }, { "database": "PubMed", "id": "19098003", "url": "https://glygen.org/publication/PubMed/19098003" } ] }, { "start_pos": 861, "end_pos": 861, "sequence_org": "D", "sequence_mut": "Y", "comment": "Loss of kinase activity.", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" }, { "database": "PubMed", "id": "19098003", "url": "https://glygen.org/publication/PubMed/19098003" } ] }, { "start_pos": 864, "end_pos": 864, "sequence_org": "L", "sequence_mut": "R", "comment": "Strongly reduced autophosphorylation.", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" }, { "database": "PubMed", "id": "18287036", "url": "https://glygen.org/publication/PubMed/18287036" } ] }, { "start_pos": 872, "end_pos": 872, "sequence_org": "E", "sequence_mut": "K", "comment": "No effect on kinase activity.", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" }, { "database": "PubMed", "id": "19098003", "url": "https://glygen.org/publication/PubMed/19098003" } ] }, { "start_pos": 926, "end_pos": 926, "sequence_org": "T", "sequence_mut": "M", "comment": "No effect on kinase activity.", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" }, { "database": "PubMed", "id": "19098003", "url": "https://glygen.org/publication/PubMed/19098003" } ] }, { "start_pos": 947, "end_pos": 947, "sequence_org": "I", "sequence_mut": "R", "comment": "Constitutively autophosphorylated.", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" }, { "database": "PubMed", "id": "18287036", "url": "https://glygen.org/publication/PubMed/18287036" } ] }, { "start_pos": 992, "end_pos": 992, "sequence_org": "R", "sequence_mut": "A", "comment": "Abolishes APC/C-mediated degradation; when associated with A-995 and A-1000.", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" }, { "database": "PubMed", "id": "17638867", "url": "https://glygen.org/publication/PubMed/17638867" } ] }, { "start_pos": 995, "end_pos": 995, "sequence_org": "L", "sequence_mut": "A", "comment": "Abolishes APC/C-mediated degradation; when associated with A-992 and A-1000.", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" }, { "database": "PubMed", "id": "17638867", "url": "https://glygen.org/publication/PubMed/17638867" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "80.35", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000178568", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000178568" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "43.86", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000178568", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000178568" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "63.37", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000178568", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000178568" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "49.96", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000178568", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000178568" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "49.53", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000178568", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000178568" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "44.26", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000178568", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000178568" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "47.76", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000178568", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000178568" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "48.71", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000178568", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000178568" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "67.63", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000178568", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000178568" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "47.6", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000178568", "url": 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"MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] } ] }, { "significant": "No", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "Q15303", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q15303" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] } ] }, { "significant": "No", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "Q15303", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q15303" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "11054", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11054" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Head and neck cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "Q15303", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q15303" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ], "unlinked_id_list": [ "DOID:1542" ], "evidence": [ { "id": "11934", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11934" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Lung cancer [DO disease 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"1328954", "url": "https://www.iedb.org/epitope/1328954", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1336847", "url": "https://www.iedb.org/epitope/1336847", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1591023", "url": "https://www.iedb.org/epitope/1591023", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1964522", "url": "https://www.iedb.org/epitope/1964522", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2020226", "url": "https://www.iedb.org/epitope/2020226", "database": "IEDB", "categories": [ "Other" ] }, { "id": "2052772", "url": "https://www.iedb.org/epitope/2052772", "database": "IEDB", "categories": [ "Other" ] }, { "id": "433699", "url": "https://www.iedb.org/epitope/433699", "database": "IEDB", "categories": [ "Other" ] }, { "id": "509176", "url": "https://www.iedb.org/epitope/509176", "database": "IEDB", "categories": [ "Other" ] }, { "id": "701726", "url": "https://www.iedb.org/epitope/701726", "database": "IEDB", "categories": [ "Other" ] }, { "id": "706514", "url": "https://www.iedb.org/epitope/706514", "database": "IEDB", "categories": [ "Other" ] }, { "id": "709890", "url": "https://www.iedb.org/epitope/709890", "database": "IEDB", "categories": [ "Other" ] }, { "id": "711850", "url": "https://www.iedb.org/epitope/711850", "database": "IEDB", "categories": [ "Other" ] }, { "id": "712895", "url": "https://www.iedb.org/epitope/712895", "database": "IEDB", "categories": [ "Other" ] }, { "id": "712954", "url": "https://www.iedb.org/epitope/712954", "database": "IEDB", "categories": [ "Other" ] }, { "id": "712955", "url": "https://www.iedb.org/epitope/712955", "database": "IEDB", "categories": [ "Other" ] }, { "id": "717135", "url": "https://www.iedb.org/epitope/717135", "database": "IEDB", "categories": [ "Other" ] }, { "id": "731200", "url": "https://www.iedb.org/epitope/731200", "database": "IEDB", "categories": [ "Other" ] }, { "id": "791314", "url": "https://www.iedb.org/epitope/791314", "database": "IEDB", "categories": [ "Other" ] }, { "id": "877017", "url": "https://www.iedb.org/epitope/877017", "database": "IEDB", "categories": [ "Other" ] }, { "id": "Q15303", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q15303*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000494", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000494", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001245", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001245", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006211", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006211", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006212", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006212", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008266", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008266", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016245", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016245", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020635", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020635", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032778", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032778", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036941", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036941", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049328", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049328", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050122", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050122", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051648", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051648", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:2066", "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:2066", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "600543", "url": "http://www.omim.org/entry/600543", "database": "MIM", "categories": [ "Other" ] }, { "id": "615515", "url": "http://www.omim.org/entry/615515", "database": "MIM", "categories": [ "Other" ] }, { "id": "VCHSECL", "url": "https://omabrowser.org/oma/group/VCHSECL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E9PDR1", "url": "https://www.orthodb.org/?gene=E9PDR1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "H3BLT0", "url": "https://www.orthodb.org/?gene=H3BLT0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q15303", "url": "https://www.orthodb.org/?gene=Q15303", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24416", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24416", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24416:SF90", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24416:SF90", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31018:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31018:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00002ahx", "url": "https://www.rcsb.org/structure/pdb_00002ahx", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00002l2t", "url": "https://www.rcsb.org/structure/pdb_00002l2t", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00002lcx", "url": "https://www.rcsb.org/structure/pdb_00002lcx", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00002r4b", "url": "https://www.rcsb.org/structure/pdb_00002r4b", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00003bbt", "url": "https://www.rcsb.org/structure/pdb_00003bbt", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00003bbw", "url": "https://www.rcsb.org/structure/pdb_00003bbw", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00003bce", "url": "https://www.rcsb.org/structure/pdb_00003bce", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00003u2p", "url": "https://www.rcsb.org/structure/pdb_00003u2p", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00003u7u", "url": "https://www.rcsb.org/structure/pdb_00003u7u", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00003u9u", "url": "https://www.rcsb.org/structure/pdb_00003u9u", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00008u4i", "url": "https://www.rcsb.org/structure/pdb_00008u4i", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00008u4j", "url": "https://www.rcsb.org/structure/pdb_00008u4j", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00008u4k", "url": "https://www.rcsb.org/structure/pdb_00008u4k", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00008u4l", "url": "https://www.rcsb.org/structure/pdb_00008u4l", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2AHX", "url": "https://www.rcsb.org/structure/2AHX", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2L2T", "url": "https://www.rcsb.org/structure/2L2T", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2LCX", "url": "https://www.rcsb.org/structure/2LCX", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2R4B", "url": "https://www.rcsb.org/structure/2R4B", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3BBT", "url": "https://www.rcsb.org/structure/3BBT", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3BBW", "url": "https://www.rcsb.org/structure/3BBW", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3BCE", "url": "https://www.rcsb.org/structure/3BCE", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3U2P", "url": "https://www.rcsb.org/structure/3U2P", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3U7U", "url": "https://www.rcsb.org/structure/3U7U", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3U9U", "url": "https://www.rcsb.org/structure/3U9U", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8U4I", "url": "https://www.rcsb.org/structure/8U4I", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8U4J", "url": "https://www.rcsb.org/structure/8U4J", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8U4K", "url": "https://www.rcsb.org/structure/8U4K", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8U4L", "url": "https://www.rcsb.org/structure/8U4L", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00757", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00757", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF01030", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01030", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF07714", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07714", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF14843", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14843", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF21314", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21314", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "Q15303", "url": "https://pharos.nih.gov/targets/Q15303", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR:Q15303", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:Q15303", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001036064", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036064", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10596", "url": "https://www.rhea-db.org/rhea/10596", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "E9PDR1", "url": "https://www.uniprot.org/uniprotkb/E9PDR1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PDR1-1", "url": "https://www.uniprot.org/uniprotkb/E9PDR1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H3BLT0", "url": "https://www.uniprot.org/uniprotkb/H3BLT0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H3BLT0-1", "url": "https://www.uniprot.org/uniprotkb/H3BLT0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q15303-1", "url": "https://www.uniprot.org/uniprotkb/Q15303-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q15303-2", "url": "https://www.uniprot.org/uniprotkb/Q15303-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q15303-3", "url": "https://www.uniprot.org/uniprotkb/Q15303-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q15303-4", "url": "https://www.uniprot.org/uniprotkb/Q15303-4", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV", "length": 1308, "header": "sp|Q15303-1|ERBB4_HUMAN Isoform 1 of Receptor tyrosine-protein kinase erbB-4 OS=Homo sapiens OX=9606 GN=ERBB4 PE=1 SV=1 CANONICAL=Q15303-1" }, "isoforms": [ { "isoform_ac": "E9PDR1-1", "url": "https://www.uniprot.org/uniprotkb/Q15303/entry#E9PDR1-1", "sequence": { "sequence": "MGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCG", "length": 128, "header": "tr|E9PDR1-1|ERBB4_HUMAN Computationally mapped isoform of Receptor tyrosine-protein kinase erbB-4 OS=Homo sapiens OX=9606 GN=ERBB4 PE=1 SV=1 CANONICAL=Q15303-1" }, "locus": { "chromosome": "2", "start_pos": 212124808, "end_pos": 211750700, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000435846.1", "url": "https://www.ensembl.org/id/ENST00000435846.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000405564.1", "url": "https://www.ensembl.org/id/ENSP00000405564.1" } ] } }, { "isoform_ac": "H3BLT0-1", "url": "https://www.uniprot.org/uniprotkb/Q15303/entry#H3BLT0-1", "sequence": { "sequence": "XKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCIGSSIEDCIGLMDRTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEG", "length": 731, "header": "tr|H3BLT0-1|ERBB4_HUMAN Computationally mapped isoform of Receptor tyrosine-protein kinase erbB-4 OS=Homo sapiens OX=9606 GN=ERBB4 PE=1 SV=1 CANONICAL=Q15303-1" }, "locus": {} }, { "isoform_ac": "Q15303-1", "url": "https://www.uniprot.org/uniprotkb/Q15303/entry#Q15303-1", "sequence": { "sequence": "MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV", "length": 1308, "header": "sp|Q15303-1|ERBB4_HUMAN Isoform 1 of Receptor tyrosine-protein kinase erbB-4 OS=Homo sapiens OX=9606 GN=ERBB4 PE=1 SV=1 CANONICAL=Q15303-1" }, "locus": { "chromosome": "2", "start_pos": 212538530, "end_pos": 211383618, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000342788.9", "url": "https://www.ensembl.org/id/ENST00000342788.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000342235.4", "url": "https://www.ensembl.org/id/ENSP00000342235.4" } ] } }, { "isoform_ac": "Q15303-2", "url": "https://www.uniprot.org/uniprotkb/Q15303/entry#Q15303-2", "sequence": { "sequence": "MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCIGSSIEDCIGLMDRTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV", "length": 1298, "header": "sp|Q15303-2|ERBB4_HUMAN Isoform 2 of Receptor tyrosine-protein kinase erbB-4 OS=Homo sapiens OX=9606 GN=ERBB4 PE=1 SV=1 CANONICAL=Q15303-1" }, "locus": {} }, { "isoform_ac": "Q15303-3", "url": "https://www.uniprot.org/uniprotkb/Q15303/entry#Q15303-3", "sequence": { "sequence": "MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV", "length": 1292, "header": "sp|Q15303-3|ERBB4_HUMAN Isoform 3 of Receptor tyrosine-protein kinase erbB-4 OS=Homo sapiens OX=9606 GN=ERBB4 PE=1 SV=1 CANONICAL=Q15303-1" }, "locus": { "chromosome": "2", "start_pos": 212538530, "end_pos": 211383618, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000436443.5", "url": "https://www.ensembl.org/id/ENST00000436443.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000403204.1", "url": "https://www.ensembl.org/id/ENSP00000403204.1" } ] } }, { "isoform_ac": "Q15303-4", "url": "https://www.uniprot.org/uniprotkb/Q15303/entry#Q15303-4", "sequence": { "sequence": "MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCIGSSIEDCIGLMDRTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV", "length": 1282, "header": "sp|Q15303-4|ERBB4_HUMAN Isoform 4 of Receptor tyrosine-protein kinase erbB-4 OS=Homo sapiens OX=9606 GN=ERBB4 PE=1 SV=1 CANONICAL=Q15303-1" }, "locus": { "chromosome": "2", "start_pos": 212538530, "end_pos": 211383618, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000260943.11", "url": "https://www.ensembl.org/id/ENST00000260943.11" }, { "database": "Ensembl Peptide", "id": "ENSP00000260943.7", "url": "https://www.ensembl.org/id/ENSP00000260943.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G02815KT", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "nLTEILNGGVYVDQNK", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 138, "start_aa": "Asn", "end_pos": 138, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn138", "evidence": [ { "id": "37074911", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37074911" }, { "id": "PDC000471", "database": "PDC", "url": "https://proteomic.datacommons.cancer.gov/pdc/study/PDC000471" } ], "filter_code": "00100000000000000000.0000000.00010000000000.0100000.1100000000.110111110111111111.00010.01001" }, { "glytoucan_ac": "G22768VO", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": { "label": "iCn3D", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?bcifid=8U4I&bu=0&command=select+.B:138;+center+selection;+zoom+selection" }, "start_pos": 138, "start_aa": "Asn", "end_pos": 138, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn138", "evidence": [ { "id": "8U4I", "database": "PDB", "url": "https://www.rcsb.org/structure/8U4I" }, { "id": "8U4I", "database": "PDB", "url": "https://www.rcsb.org/structure/8U4I" }, { "id": "8U4J", "database": "PDB", "url": "https://www.rcsb.org/structure/8U4J" }, { "id": "8U4J", "database": "PDB", "url": "https://www.rcsb.org/structure/8U4J" }, { "id": "8U4I|B|138", "database": "", "url": "" }, { "id": "8U4I|A|138", "database": "", "url": "" }, { "id": "8U4J|B|138", "database": "", "url": "" }, { "id": "8U4J|A|138", "database": "", "url": "" } ], "filter_code": "00100000000000000000.0000000.00010000000000.1000000.1100000000.111100100111111101.10000.01001" }, { "glytoucan_ac": "G31852PQ", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "nLTEILNGGVYVDQNK", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 138, "start_aa": "Asn", "end_pos": 138, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn138", "evidence": [ { "id": "37074911", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37074911" }, { "id": "PDC000471", "database": "PDC", "url": "https://proteomic.datacommons.cancer.gov/pdc/study/PDC000471" } ], "filter_code": "00100000000000000000.0000000.00010000000000.0100000.1100000000.110111110111111110.00010.01001" }, { "glytoucan_ac": "G41247ZX", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "nLTEILNGGVYVDQNK", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 138, "start_aa": "Asn", "end_pos": 138, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn138", "evidence": [ { "id": "37074911", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37074911" }, { "id": "PDC000471", "database": "PDC", "url": "https://proteomic.datacommons.cancer.gov/pdc/study/PDC000471" } ], "filter_code": "00100000000000000000.0000000.00010000000000.0100000.1100000000.111111110111111110.00010.01001" }, { "glytoucan_ac": "G81315DD", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": { "label": "iCn3D", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?bcifid=8U4K&bu=0&command=select+.A:138;+center+selection;+zoom+selection" }, "start_pos": 138, "start_aa": "Asn", "end_pos": 138, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn138", "evidence": [ { "id": "8U4K", "database": "PDB", "url": "https://www.rcsb.org/structure/8U4K" }, { "id": "8U4K", "database": "PDB", "url": "https://www.rcsb.org/structure/8U4K" }, { "id": "8U4L", "database": "PDB", "url": "https://www.rcsb.org/structure/8U4L" }, { "id": "8U4L", "database": "PDB", "url": "https://www.rcsb.org/structure/8U4L" }, { "id": "8U4K|A|138", "database": "", "url": "" }, { "id": "8U4L|A|138", "database": "", "url": "" } ], "filter_code": "00100000000000000000.0000000.00010000000000.1000000.1100000000.110100100101111111.10000.01001" }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "reported", "site_category_dict": { "reported": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": { "label": "iCn3D", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?bcifid=2AHX&bu=0&command=select+.B:113;+center+selection;+zoom+selection" }, "start_pos": 138, "start_aa": "Asn", "end_pos": 138, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn138", "evidence": [ { "id": "Q15303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q15303#ptm_processing" }, { "id": "16203964", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/16203964" }, { "id": "2AHX", "database": "PDB", "url": "https://www.rcsb.org/structure/2AHX" }, { "id": "2AHX", "database": "PDB", "url": "https://www.rcsb.org/structure/2AHX" }, { "id": "3U2P", "database": "PDB", "url": "https://www.rcsb.org/structure/3U2P" }, { "id": "3U2P", "database": "PDB", "url": "https://www.rcsb.org/structure/3U2P" }, { "id": "3U7U", "database": "PDB", "url": "https://www.rcsb.org/structure/3U7U" }, { "id": "3U7U", "database": "PDB", "url": "https://www.rcsb.org/structure/3U7U" }, { "id": "2AHX|B|113", "database": "", "url": "" }, { "id": "2AHX|A|113", "database": "", "url": "" }, { "id": "3U2P|A|113", "database": "", "url": "" }, { "id": "3U7U|A|113", "database": "", "url": "" }, { "id": "3U7U|B|113", "database": "", "url": "" }, { "id": "3U7U|C|113", "database": "", "url": "" }, { "id": "3U7U|D|113", "database": "", "url": "" }, { "id": "3U7U|E|113", "database": "", "url": "" }, { "id": "3U7U|F|113", "database": "", "url": "" } ], "filter_code": "00100000000000000000.00010000000000.00.01001" }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "reported", "site_category_dict": { "reported": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": { "label": "iCn3D", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?bcifid=2AHX&bu=0&command=select+.B:149;+center+selection;+zoom+selection" }, "start_pos": 174, "start_aa": "Asn", "end_pos": 174, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn174", "evidence": [ { "id": "Q15303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q15303#ptm_processing" }, { "id": "16203964", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/16203964" }, { "id": "2AHX", "database": "PDB", "url": "https://www.rcsb.org/structure/2AHX" }, { "id": "2AHX", "database": "PDB", "url": "https://www.rcsb.org/structure/2AHX" }, { "id": "2AHX|B|149", "database": "", "url": "" }, { "id": "2AHX|A|149", "database": "", "url": "" } ], "filter_code": "00100000000000000000.00010000000000.00.01001" }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "reported", "site_category_dict": { "reported": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": { "label": "iCn3D", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?bcifid=2AHX&bu=0&command=select+.B:156;+center+selection;+zoom+selection" }, "start_pos": 181, "start_aa": "Asn", "end_pos": 181, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn181", "evidence": [ { "id": "Q15303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q15303#ptm_processing" }, { "id": "2AHX", "database": "PDB", "url": "https://www.rcsb.org/structure/2AHX" }, { "id": "2AHX", "database": "PDB", "url": "https://www.rcsb.org/structure/2AHX" }, { "id": "2AHX|B|156", "database": "", "url": "" } ], "filter_code": "00100000000000000000.00010000000000.00.01001" }, { "glytoucan_ac": "G22768VO", "type": "N-linked", "subtype": 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Natl. Acad. Sci. U.S.A.", "date": "2000", "authors": "Garcia RA, Vasudevan K, Buonanno A", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "reference": [ { "type": "PubMed", "id": "10725395", "url": "https://glygen.org/publication/PubMed/10725395" } ] }, { "title": "Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Rio C, Buxbaum JD, Peschon JJ, Corfas G", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "reference": [ { "type": "PubMed", "id": "10744726", "url": "https://glygen.org/publication/PubMed/10744726" } ] }, { "title": "Ligand discrimination in signaling through an ErbB4 receptor homodimer.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Sweeney C, Lai C, Riese DJ 2nd, Diamonti AJ, Cantley LC, Carraway KL 3rd", "evidence": 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Worley KC, Rives CM, Gorrell JH, Metzker ML, Naylor SL, Kucherlapati RS, Nelson DL, Weinstock GM, Sakaki Y, Fujiyama A, Hattori M, Yada T, Toyoda A, Itoh T, Kawagoe C, Watanabe H, Totoki Y, Taylor T, Weissenbach J, Heilig R, Saurin W, Artiguenave F, Brottier P, Bruls T, Pelletier E, Robert C, Wincker P, Smith DR, Doucette-Stamm L, Rubenfield M, Weinstock K, Lee HM, Dubois J, Rosenthal A, Platzer M, Nyakatura G, Taudien S, Rump A, Yang H, Yu J, Wang J, Huang G, Gu J, Hood L, Rowen L, Madan A, Qin S, Davis RW, Federspiel NA, Abola AP, Proctor MJ, Myers RM, Schmutz J, Dickson M, Grimwood J, Cox DR, Olson MV, Kaul R, Raymond C, Shimizu N, Kawasaki K, Minoshima S, Evans GA, Athanasiou M, Schultz R, Roe BA, Chen F, Pan H, Ramser J, Lehrach H, Reinhardt R, McCombie WR, de la Bastide M, Dedhia N, Blocker H, Hornischer K, Nordsiek G, Agarwala R, Aravind L, Bailey JA, Bateman A, Batzoglou S, Birney E, Bork P, Brown DG, Burge CB, Cerutti L, Chen HC, Church D, Clamp M, Copley RR, Doerks T, Eddy 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neuregulin-ErbB4 pathway cause amyotrophic lateral sclerosis type 19.", "journal": "American journal of human genetics", "date": "2013", "authors": "Takahashi Y, Fukuda Y, Yoshimura J, Toyoda A, Kurppa K, Moritoyo H, Belzil VV, Dion PA, Higasa K, Doi K, Ishiura H, Mitsui J, Date H, Ahsan B, Matsukawa T, Ichikawa Y, Moritoyo T, Ikoma M, Hashimoto T, Kimura F, Murayama S, Onodera O, Nishizawa M, Yoshida M, Atsuta N, Sobue G, Fifita JA, Williams KL, Blair IP, Nicholson GA, Gonzalez-Perez P, Brown RH Jr, Nomoto M, Elenius K, Rouleau GA, Fujiyama A, Morishita S, Goto J, Tsuji S", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "reference": [ { "type": "PubMed", "id": "24119685", "url": "https://glygen.org/publication/PubMed/24119685" } ] }, { "title": "The nature and extent of contributions by defective ribosome products to the HLA peptidome.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2014-04-22", "authors": "Bourdetsky Dmitry, Schmelzer Christian E H, Admon Arie", "evidence": [ { "database": "IEDB", "id": "509176", "url": "https://www.iedb.org/epitope/509176" } ], "reference": [ { "type": "PubMed", "id": "24715725", "url": "https://glygen.org/publication/PubMed/24715725" } ] }, { "title": "Multiple Functional Motifs Are Required for the Tumor Suppressor Activity of a Constitutively-Active ErbB4 Mutant.", "journal": "Journal of cancer research and therapeutic oncology", "date": "2013", "authors": "Gallo RM, Bryant IN, Mill CP, Kaverman S, Riese DJ 2nd", "evidence": [ { "database": "iPTMnet", "id": "Q15303", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q15303" } ], "reference": [ { "type": "PubMed", "id": "24791013", "url": "https://glygen.org/publication/PubMed/24791013" } ] }, { "title": "A comprehensive analysis of peptides presented by HLA-A1.", "journal": "Tissue antigens", "date": "2015-06", "authors": "Giam K, Ayala-Perez R, Illing P T, Schittenhelm R B, Croft N P, Purcell A W, Dudek N L", "evidence": [ { "database": "IEDB", "id": "433699", "url": "https://www.iedb.org/epitope/433699" } ], "reference": [ { "type": "PubMed", "id": "25880248", "url": "https://glygen.org/publication/PubMed/25880248" } ] }, { "title": "Antitumor efficacy of the heparan sulfate mimic roneparstat (SST0001) against sarcoma models involves multi-target inhibition of receptor tyrosine kinases.", "journal": "Oncotarget", "date": "2016-07-26", "authors": "Cassinelli Giuliana, Favini Enrica, Dal Bo Laura, Tortoreto Monica, De Maglie Marcella, Dagrada Gianpaolo, Pilotti Silvana, Zunino Franco, Zaffaroni Nadia, Lanzi Cinzia", "evidence": [ { "database": "iPTMnet", "id": "Q15303", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q15303" } ], "reference": [ { "type": "PubMed", "id": "27374103", "url": "https://glygen.org/publication/PubMed/27374103" } ] }, { "title": "Comparative study on driver mutations in primary and 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Induction of cell death by antibody-dependent HER4 intracellular domain trafficking.", "journal": "Cancer science", "date": "2020-07", "authors": "Lanotte Romain, Garambois V\u00e9ronique, Gaborit Nad\u00e8ge, Larbouret Christel, Musnier Astrid, Martineau Pierre, P\u00e8legrin Andr\u00e9, Chard\u00e8s Thierry", "evidence": [ { "database": "iPTMnet", "id": "Q15303", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q15303" } ], "reference": [ { "type": "PubMed", "id": "32415868", "url": "https://glygen.org/publication/PubMed/32415868" } ] }, { "title": "Mild Acid Elution and MHC Immunoaffinity Chromatography Reveal Similar Albeit Not Identical Profiles of the HLA Class I Immunopeptidome.", "journal": "Journal of proteome research", "date": "2021-01-01", "authors": "Sturm Theo, Sautter Benedikt, W\u00f6rner Tobias P, Stevanovi\u0107 Stefan, Rammensee Hans-Georg, Planz Oliver, Heck Albert J R, Aebersold Ruedi", "evidence": [ { "database": "IEDB", "id": "1336847", "url": "https://www.iedb.org/epitope/1336847" } ], "reference": [ { "type": "PubMed", "id": "33141586", "url": "https://glygen.org/publication/PubMed/33141586" } ] }, { "title": "Thermostability profiling of MHC-bound peptides: a new dimension in immunopeptidomics and aid for immunotherapy design.", "journal": "Nature communications", "date": "2020-12-09", "authors": "Jappe Emma C, Garde Christian, Ramarathinam Sri H, Passantino Ethan, Illing Patricia T, Mifsud Nicole A, Trolle Thomas, Kringelum Jens V, Croft Nathan P, Purcell Anthony W", "evidence": [ { "database": "IEDB", "id": "509176", "url": "https://www.iedb.org/epitope/509176" }, { "database": "IEDB", "id": "717135", "url": "https://www.iedb.org/epitope/717135" } ], "reference": [ { "type": "PubMed", "id": "33298915", "url": "https://glygen.org/publication/PubMed/33298915" } ] }, { "title": "The Impact of Biomaterial Cell Contact on the Immunopeptidome.", "journal": "Frontiers in bioengineering and biotechnology", "date": "2020", "authors": "Ghosh Michael, Hartmann Hanna, Jakobi Meike, M\u00e4rz L\u00e9o, Bichmann Leon, Freudenmann Lena K, M\u00fchlenbruch Lena, Segan S\u00f6ren, Rammensee Hans-Georg, Schneiderhan-Marra Nicole, Shipp Christopher, Stevanovi\u0107 Stefan, Joos Thomas O", "evidence": [ { "database": "IEDB", "id": "1316284", "url": "https://www.iedb.org/epitope/1316284" } ], "reference": [ { "type": "PubMed", "id": "33392160", "url": "https://glygen.org/publication/PubMed/33392160" } ] }, { "title": "Carbamazepine Induces Focused T Cell Responses in Resolved Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Cases But Does Not Perturb the Immunopeptidome for T Cell Recognition.", "journal": "Frontiers in immunology", "date": "2021", "authors": "Mifsud Nicole A, Illing Patricia T, Lai Jeffrey W, Fettke Heidi, Hensen Luca, Huang Ziyi, Rossjohn Jamie, Vivian Julian P, Kwan Patrick, Purcell Anthony W", "evidence": [ { "database": "IEDB", "id": "701726", "url": "https://www.iedb.org/epitope/701726" 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"IEDB", "id": "2020226", "url": "https://www.iedb.org/epitope/2020226" }, { "database": "IEDB", "id": "2052772", "url": "https://www.iedb.org/epitope/2052772" } ], "reference": [ { "type": "PubMed", "id": "35051231", "url": "https://glygen.org/publication/PubMed/35051231" } ] }, { "title": "Accurate MHC Motif Deconvolution of Immunopeptidomics Data Reveals a Significant Contribution of DRB3, 4 and 5 to the Total DR Immunopeptidome.", "journal": "Frontiers in immunology", "date": "2022", "authors": "Kaabinejadian Saghar, Barra Carolina, Alvarez Bruno, Yari Hooman, Hildebrand William H, Nielsen Morten", "evidence": [ { "database": "IEDB", "id": "1964522", "url": "https://www.iedb.org/epitope/1964522" } ], "reference": [ { "type": "PubMed", "id": "35154160", "url": "https://glygen.org/publication/PubMed/35154160" } ] }, { "title": "Tumour-associated antigenic peptides are present in the HLA class I ligandome of cancer cell line derived extracellular vesicles.", "journal": "Immunology", 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France)", "date": "2023-11-30", "authors": "Tang Rongrong, Cui Haiyan, Dou Rongrong, Tao Lin, Tan Linlin, Guo Ting, Luo Dan", "evidence": [ { "database": "RefSeq", "id": "NP_001036064", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036064" } ], "reference": [ { "type": "PubMed", "id": "38063127", "url": "https://glygen.org/publication/PubMed/38063127" } ] }, { "title": "Genetic variants of ERBB4 gene and risk of gestational diabetes mellitus: a susceptibility and diagnostic nomogram study.", "journal": "Frontiers in endocrinology", "date": "2023", "authors": "Li Ruiqi, Wang Yukun, Yang Lin, Zhong Ping, Huang Gongchen, Liang Qiulian, Yu Xiangyuan", "evidence": [ { "database": "RefSeq", "id": "NP_001036064", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036064" } ], "reference": [ { "type": "PubMed", "id": "38149095", "url": "https://glygen.org/publication/PubMed/38149095" } ] }, { "title": "Neuregulin-1 and ALS19 (ERBB4): at the crossroads of amyotrophic lateral sclerosis and cancer.", "journal": "BMC medicine", "date": "2024-02-19", "authors": "Adashek Jacob J, Pandya Chinmayi, Maragakis Nicholas J, De Pradip, Cohen Philip R, Kato Shumei, Kurzrock Razelle", "evidence": [ { "database": "RefSeq", "id": "NP_001036064", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036064" } ], "reference": [ { "type": "PubMed", "id": "38369520", "url": "https://glygen.org/publication/PubMed/38369520" } ] }, { "title": "HER4 is a high-affinity dimerization partner for all EGFR/HER/ErbB family proteins.", "journal": "Protein science : a publication of the Protein Society", "date": "2024-10", "authors": "Singh Pradeep Kumar, Kim Soyeon, Smith Adam W", "evidence": [ { "database": "RefSeq", "id": "NP_001036064", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036064" } ], "reference": [ { "type": "PubMed", "id": "39276020", "url": "https://glygen.org/publication/PubMed/39276020" } ] }, { "title": "The role and mechanism of NRG1/ErbB4 in inducing the differentiation of induced pluripotent stem cells into cardiomyocytes.", "journal": "BMC cardiovascular disorders", "date": "2024-10-16", "authors": "Li Xiaoou, Zhang Heng, Li Wenjing, Tuo Hu, He Bing, Jiang Hong", "evidence": [ { "database": "RefSeq", "id": "NP_001036064", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036064" } ], "reference": [ { "type": "PubMed", "id": "39407109", "url": "https://glygen.org/publication/PubMed/39407109" } ] }, { "title": "Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor.", "journal": "J. Biol. Chem.", "date": "1993", "authors": "Culouscou J M, Plowman G D, Carlton G W, Green J M, Shoyab M", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "reference": [ { "type": "PubMed", "id": "7689552", "url": "https://glygen.org/publication/PubMed/7689552" } ] }, { "title": "Heregulin induces tyrosine phosphorylation of HER4/p180erbB4.", "journal": "Nature", "date": "1993", "authors": "Plowman G D, Green J M, Culouscou J M, Carlton G W, Rothwell V M, Buckley S", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "reference": [ { "type": "PubMed", "id": "7902537", "url": "https://glygen.org/publication/PubMed/7902537" } ] }, { "title": "Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1993-03-01", "authors": "Plowman G D, Culouscou J M, Whitney G S, Green J M, Carlton G W, Foy L, Neubauer M G, Shoyab M", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "reference": [ { "type": "PubMed", "id": "8383326", "url": "https://glygen.org/publication/PubMed/8383326" } ] }, { "title": "Betacellulin activates the epidermal growth factor receptor and erbB-4, and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-beta.", "journal": "Oncogene", "date": "1996", "authors": "Riese D J, Bermingham Y, van Raaij T M, Buckley S, Plowman G D, Stern D F", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "reference": [ { "type": "PubMed", "id": "8570211", "url": "https://glygen.org/publication/PubMed/8570211" } ] }, { "title": "HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers.", "journal": "The Journal of biological chemistry", "date": "1996", "authors": "Cohen BD, Green JM, Foy L, Fell HP", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" }, { "database": "iPTMnet", "id": "Q15303", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q15303" } ], "reference": [ { "type": "PubMed", "id": "8617750", "url": "https://glygen.org/publication/PubMed/8617750" } ] }, { "title": "Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation.", "journal": "The EMBO journal", "date": "1997", "authors": "Elenius K, Paul S, Allison G, Sun J, Klagsbrun M", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "reference": [ { "type": "PubMed", "id": "9135143", "url": "https://glygen.org/publication/PubMed/9135143" } ] }, { "title": "Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases.", "journal": "Nature", "date": "1997", "authors": "Carraway KL 3rd, Weber JL, Unger MJ, Ledesma J, Yu N, Gassmann M, Lai C", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "reference": [ { "type": "PubMed", "id": "9168115", "url": "https://glygen.org/publication/PubMed/9168115" } ] }, { "title": "Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1997", "authors": "Zhang D, Sliwkowski MX, Mark M, Frantz G, Akita R, Sun Y, Hillan K, Crowley C, Brush J, Godowski PJ", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "reference": [ { "type": "PubMed", "id": "9275162", "url": "https://glygen.org/publication/PubMed/9275162" } ] }, { "title": "A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester.", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Elenius K, Corfas G, Paul S, Choi CJ, Rio C, Plowman GD, Klagsbrun M", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "reference": [ { "type": "PubMed", "id": "9334263", "url": "https://glygen.org/publication/PubMed/9334263" } ] }, { "title": "Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4.", "journal": "Oncogene", "date": "1997", "authors": "Komurasaki T, Toyoda H, Uchida D, Morimoto S", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "reference": [ { "type": "PubMed", "id": "9419975", "url": "https://glygen.org/publication/PubMed/9419975" } ] }, { "title": "Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3.", "journal": "J. Biol. Chem.", "date": "1998", "authors": "Fiddes RJ, Campbell DH, Janes PW, Sivertsen SP, Sasaki H, Wallasch C, Daly RJ", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "reference": [ { "type": "PubMed", "id": "9516479", "url": "https://glygen.org/publication/PubMed/9516479" } ] } ], "pathway": [ { "id": "hsa:2066", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:2066", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M1N4R3-1", "protein_name": "Receptor protein-tyrosine kinase", "gene_name": "erbb3b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGQQVLALCALLFLCVPQPVTSQTQEVCTGTKNALSSTGTPEQHYNNLKERYTGCEIVMGNLEITQMENDLDFSFLGSIREVTGYILIAMNQFRKLPLNQLRVIRGSSLYDKEWALSVFHNFDTHTGLEDLGLTNLTEILEGGVQIVHNRNLSYAPLINWQDIVRDGDARIQIQDNGGRGSCNPACGEFCWGPSNDQCQKLTKTVCALQCLGHCFGTNPNECCHPECAGGCTGPRDTDCFACRHVNYSGSCVPHCPWPVVYNQQTFQVEPNADAMYQFGSICVPKCPGHFVVDGSACVSSCPPGKTEIEKNQIKQCETCIGLCPKVCEGTGANHRQTVDSSNIDSFINCTKIQGSLHFLILGIKGDVYNNIPPLEPEKLKVFNTVREITGILNIQSWPDELHDLSVFSSLTTIQGRSLYNPKRPFSLLVMKIPSLTSLGLRSLREISDGSVYITQNMNLCYHHTINWTQIFPRNQLQRRRNDIKENKQKIQCEEEGHVCDPLCSDAGCWGPGPEQCLSCRNYSRLGTCVSHCNLYSGEPREFAASNKECLACHSECLLQNGKQTCLGKGADQCVACSNLMDGPHCVSSCPNGVNGEKGQTIFKYSTAAGHCELCHFNCTRGCTGPALRDCVDPDRNVNSSQIAGIAVAVFAGITVLLALFVLGMLYHRGLAIRRKRALRRYLESGESMEPLDPGEKGTKVHARILKPQELRKGKLLGYGVFGTVNKGFWIPEGDSLKIPVAIKTIQNRSSRQTFTEITDHMLSMGSLDHPYIVRLIGICPGASLQLITQLSPHGSLLQHLRQHKDSLDPQRLLNWCVQIAKGMYYLEEHCMAHRNLAARNILLKSDYIVQISDFGVADLLYPDDKKYVYSEHKTPIKWMALESILFGRYTHQSDVWSYGVTVWEMMSYGAEPYASMHPHDVPGLLEKGERLAQPQICTIDVYMVMVKCWMIDENVRPTFKELASEFTRMARDPPRYLVVRPAQNGSGAEESQRYVKSSHLEVGLEEEDDDEDEGLQVGFATPPLQLSPTRSHSRVRIASYKSTSEHTAPIGYLPMTPGPGDEPRQLRAQRRKIGSVRTESECSEGRGTIVDIEAIEITSQTGSLRRGRSRMDSAYISGGVSVASDPFSPGLEGVDEDHYGYVLPTERDFRSAVPHGRTSRNSKSTPKTDATQEYELMNKQTNKLSSSPTDSTDHLKPASLVSAHICSSLPQKKEMDSAQTQDEILPQKRETDSIQSQENNLPQKSETDSTQTQESEKDASFQPDNLESAENCLIGSETLNDGGQSEDEEQLPRLAMVEYEYMDIRTDEHQQNVAGKRTTNGPNEVEREAIYQNISQPLRFHENPDSAGNTMQRRGEYVDMEASGRSGCEVGDYQNVPVKGRPVVGEESQNTGLRSYIKVCAGVEPQNTSFDNPDYWHSRLFHKQDTVCT", "length": 1429 }, "evidence": [ { "id": "FB:FBgn0003731", "url": "https://alliancegenome.org/gene/FB:FBgn0003731#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8M2BD22-1", "protein_name": "Receptor protein-tyrosine kinase", "gene_name": "erbb3a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MKIMKMKSAMLQMIAMCLALRSPARAQTQEGKPEVGVCTGTQNLLSVTGSSEVQYKLMKEMYTGCQIVIGNLEITQMEHNRDFSFLQSIREVTGYILIAINQFRRLPLEQLRVIRGTSLYEDKFALAVLVNYQKDGVYGLRELGLTHLTEILEGGVQIIQNKFLSYAPQINWQDIVKNSGAEVIIQDNGPEVPCHESCGGPCWGPGNDTCQILTKTVCALQCNVRCFGRSPSECCHNECAGGCTGPLDTDCFACRNFNNSGSCVSQCPRADIYNKVTFKMEPNPNAKYQFGSMCVSHCPPNFVVDGSSCVSSCPADKMEVDKTGVKRCEKCEGLCPKACVGTGTGTASRQTVDSQNIDSFINCTKIQGSLHFLVTGIKGDSYNNISALDPKKLKIFNTVREITDILSIQSWPEELEDLSVFSNLATIQGRTLYRGVSSKRGYSLLVMKIPTLKSLGLRSLKRISDGGIYITGNTQLCYHHTVNWTRLFGSGPRALRRQKSLDIKENRPQEQCKLEGHVCDPLCSSEGCWGPGPDQCLSCKNFRRGGTCVPDCNFMSGEQREFAGPKNECMACHQECALQDSGDTCKGPGSDECKACAHLQDGPYCVSSCPEGVQGENGLIIYKFPNRQNKCQPCHANCTLGCLGPGQNDCVDSSRSSAGLPVTAIVLSVIFCVLLAFSVFVLSVLYRRSLSIRRKRAMRRYLQSGESFEPLEPGEKGVKVHARILRTSELKKIKLLGSGVFGTVHKGIWIPEGDTVKIPVAIKTIQDRTGRQTFQEITDHMLAMGSLDHAYIVRILGICPGASLQLVTQLSPQGSLLDHIRQRRDNLNPQRLLNWCVQIAKGMYYLEEQRMVHRNLAARNILLKSDLIVQIADYGIADLLYPDEKKYFFNEIKTPIKWMALESILFRRYTHQSDVWSYGVTVWEMMSYGAEPYSAMRPQDVPDLLEKGERLSQPQICTIDVYMVMVKCWMIDENVRPTFKELANEFTRMARDPHRYLVIKEEDRAPDSASDETHQNGTEIDILGVALEDQDDEVLEDAIDAPRYITPSRSFSRLRIDSHRSSLTPSTTAGYLPMTPGLESSVQTGWASRSRLDSACTVSESSEGRGALELEMNDDFSSVGSLRRVRHREDSAYMSQRDSLSGPPETTSTGTQGEEDQNEYVLPGFGESPEKETLLFTSSRSTLSQKRLSRGHSGDFLEANRGAGEEYEYMNNQTLSLSHIPGQLKEYNQRAPRNRSASFNPGGMYSNHKPSRPSKRSSIEGSESSGGLSQSSTDQRSHSDGDFLSSEAEYTDGDLEVEYEYMDIRGAGGPAANMLLKLHLPRPVSNPPLRRSPEDDDEDEDYQYSNHQPRLRNSLRVQGGGGEAYEYEDMDSLAAGGASGAEYQNLDGEDEERDEDWSGGPRSPGPYVQVHAGTNHNAFDNPDYWHSRSFHKTKAVRT", "length": 1438 }, "evidence": [ { "id": "FB:FBgn0003731", "url": "https://alliancegenome.org/gene/FB:FBgn0003731#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8M9Q7Y5-1", "protein_name": "Receptor protein-tyrosine kinase", "gene_name": "si:ch73-383l1.1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MWPVRFLLLFCLVFTFAVLQRSSGQSVCPGTDNKLSTLSDLDQQYKTLRKFYENCEVVMGNLEITSIERNRNLSFLKSIREVTGYVLVALNQFDYLPLENLRIIRGTKLYEGRYSLAIFLNYRRDGYFGLRQLGLRNLTEILNGGVYVDQNKFLCHADTIHWQDIIKNPRSELLVVPSNNSGNTCRRCHRSCNGRCWGPQEDQCQSLTKTVCAEQCDGRCFGPYVSNCCHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTTFQLEHNPNAKYTYGAFCVKKCPHNFVVDHSSCVRACPSNKTEVEENNIKMCIQCTEICPKMCDGIGTGSLQSAQTVDSSNIEKFVNCTKINGNLIFLITGIKGDMYHGIRALDPERLNVFRTVREITGYLNIQSWPENMTDLSVFSNLVTIGGRTLYSGISLLILKQRWITSLQFQSLREISAGNVYMTNNSQLCFYSTVNWTSLFRTSTQKAKIKDNRDPRECSQQRMVCDPLCSVSGCWGPGPNQCLSCKYFSRGRTCVRSCNLYNGDVREFANGSTCVECDSQCEKAEDKSLTCHGPGPDHCVKCLHLKDGPNCVEKCPDGLQGANSFIFKYPETNNECHPCHPNCTQGCTGPRIQDCIGILDRTPLIAAGVIGGMFVVVIVALGFAIFFRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKILGTGAFGTVYKGIWVPEGETVKIPVAIKILNESTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHQDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLETNEKEYSADEGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNHSKFFQSLLDEEELDDLMDADEYLVPHSLNAPPTSHIPHPHVDSNQNQFGYHDGSRCPEDVTRFHEVAAAGNAPSALGSAQRAGLDLVEEQHCNGSLKKQATVHSVEDSSGQRYSADPTVLLGEKTQREDTDEDGYMSPMKDKISTNHLNPVEENPFVTRRKSKDVHALDNPGYHNTPDGKPKCEDEYINEPLYLNTFNNTSDIHQEMLRKNGVSIPAQMTTAGHILQTGKPHHHSHGPHVHFAIPPVQPVHPGPMSQNDHNAHSVQSGHDHAVKSGPSAGQICLVSHQVQQGHPSKSNRSPQQFQLSGGKLPGHPVQPGSQIGTVLVDKMYKNSFDNPEYWQHSLPPPQISQDSSSAVCNNKFLYKQNGRVQPPAAENPEYLSGVKPGMVLPPPPYRQRNTVV", "length": 1392 }, "evidence": [ { "id": "HGNC:3432", "url": "https://alliancegenome.org/gene/HGNC:3432#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-121214-64", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-121214-64#orthology", "database": "AGR" }, { "id": "MGI:104771", "url": "https://alliancegenome.org/gene/MGI:104771#orthology", "database": "AGR" }, { "id": "RGD:620486", "url": "https://alliancegenome.org/gene/RGD:620486#orthology", "database": "AGR" }, { "id": "FB:FBgn0003731", "url": "https://alliancegenome.org/gene/FB:FBgn0003731#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8N7UZ77-1", "protein_name": "Receptor protein-tyrosine kinase", "gene_name": "erbb4a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDMQPLHTNKMRSDILIALFLTAVIVPLCTSQSVCPGTDNKLSTLSDLDQQYKTLRKFYENCEVVMGNLEITSIERNRNLSFLKSIREVTGYVLVALNQFDYLPLENLRIIRGTKLYEGRYSLAIFLNYRRDGYFGLRQLGLKNLTEILNGGVYVDQNKFLCHADTIHWHDIIKNPRSELLVVPSNNSGNTCRRCHRSCNGRCWGHQEDQCQSLTKTVCAEQCDGRCFGPYVSNCCHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTTFQLEHNPNAKYTYGAFCVKKCPHNFVVDHSSCVRACPSNKMEVEENQTKMCIPCTDICPKVCDGIGTGSLQMAQTVDSSNIEKFVNCTKINGNLIFLITGIKGDMFHGIRALDPDRLNVFRTVREITGFLNVQSWPENMTDLGVFSNLATIGGRSLYSGISLLILKQRWITSLQFQSLREISAGNVYMTNNSQLCFYSTVNWTSLFRTSTQRALIKNNREPRECSKEQKICDPLCSEAGCWGPGPDQCLSCKYFSRGKTCVKSCNLYYGDVREFANGSVCVECDSQCEKAGEKGLTCHGPGPDHCVKCLHLKDGPNCVEKCPDGLQGANSFIFKYAETNNECHPCHPNCTQGCTGPRIQDCVGILDRTPLIAAGLIGGLFVIVIIALGVAVYIRRKSIKKKRALRRFLETELVEPLTPSGAAPNQAQLRILKETELKRVKILGAGAFGMVYKGIWVPEGETVKIPVAIKILNESTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHQDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLDTDEKEYNSDGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTRDIPDILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNHSTFFKSLLDEEELDDLMDADEYLVPQTCNISTSTYTSRTTMDASWTLRCRDRVFSPEDGMGACSRDVPASASAVFVPVSTQAAGLNVLEEQHCNGSLKKQQPMSGSGDDCDGQRYSADPTVFLGERSLKNTDEDGYMSPMNKSTSDHLSPVEENPFVNHRKNGNITALDNPGYHSTPDKKSKAEEDEYINEPLYLNAYNTTGGTNLEIMRRNGSSIPLQMTTATSAASSHIILSTQPGKAHHHGQGTHVHFAIPPVQPPQTRAMSQNGQHSQSSHAVESNSSSMSANPSLLSQISLVSQQIQPCLASQSQVPKSTVPNKSISGLPGHLVYPVNMLQTGHTGTVMADRKSKKNFDNPDYWQHSLPPKVTQANPQDPTQTCKSKHLYRHSIRSRLAVADNPEFVSEFNKRPGPVLPPPPYRHRNTVV", "length": 1421 }, "evidence": [ { "id": "HGNC:3432", "url": "https://alliancegenome.org/gene/HGNC:3432#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-030918-4", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-030918-4#orthology", "database": "AGR" }, { "id": "MGI:104771", "url": "https://alliancegenome.org/gene/MGI:104771#orthology", "database": "AGR" }, { "id": "RGD:620486", "url": "https://alliancegenome.org/gene/RGD:620486#orthology", "database": "AGR" }, { "id": "FB:FBgn0003731", "url": "https://alliancegenome.org/gene/FB:FBgn0003731#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0ABK0LZB0-1", "protein_name": "Receptor protein-tyrosine kinase", "gene_name": "Egfr", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGAAAQWFALPSSPSHLCAWISLPCCLSLGCCLAVCQGTSNRLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNALYENTYALAVLSNYGTNKTGLRELPMRNLQEILIGAVRFSNNPILCNMETIQWRDIVQDVFLSNMSMDVQRHLTGCPKCDPSCPNGSCWGRGEENCQKLTKIICAQQCSRRCRGRSPSDCCHNQCAAGCTGPRESDCLVCHRFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGPDYYEVEEDGVSKCKKCDGPCRKVCNGIGIGEFKDTLSINATNIKHFKYCTAISGDLHILPVAFKGDSFTRTPPLDPRELEILKTVKEITGFLLIQAWPENWTDLHAFENLEIIRGRTKQHGQFSLAVVGLNITSLGLRSLKEISDGDVIISGNRNLCYANTINWKKLFGTPNQKTKIMNNRAEKDCKATNHVCNPLCSSEGCWGPEPTDCVSCQNVSRGRECVDKCNILEGEPREFVENSECIQCHPECLPQTMNITCTGRGPDNCIKCAHYVDGPHCVKTCPSGIMGENNTLVWKFADANNVCHLCHANCTYGCAGPGLKGCQQPEGPKIPSIATGIVGGLLFIVVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQAHLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPYGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELILEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMEEEDMEDVVDADEYLIPQQGFFNSPSTSRTPLLSSLSANSNSSAVACINRNGSCRVKEDAFLQRYSSDPTSVLTEDNIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLHPAPGRDLHYQNPHSNAVSNPEYLNTAQPTCLSSGFDSSALWIQKGSHQMSLDNPDYQQDFFPKEAKPNGIFKGPTAENAEYLRVAPPSSEFIGA", "length": 1214 }, "evidence": [ { "id": "FB:FBgn0003731", "url": "https://alliancegenome.org/gene/FB:FBgn0003731#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P00533-1", "protein_name": "Epidermal growth factor receptor", "gene_name": "EGFR", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA", "length": 1210 }, "evidence": [ { "id": "FB:FBgn0003731", "url": "https://alliancegenome.org/gene/FB:FBgn0003731#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P04412-1", "protein_name": "Epidermal growth factor receptor", "gene_name": "Egfr", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLLRRRNGPCPFPLLLLLLAHCICIWPASAARDRYARQNNRQRHQDIDRDRDRDRFLYRSSSAQNRQRGGANFALGLGANGVTIPTSLEDKNKNEFVKGKICIGTKSRLSVPSNKEHHYRNLRDRYTNCTYVDGNLKLTWLPNENLDLSFLDNIREVTGYILISHVDVKKVVFPKLQIIRGRTLFSLSVEEEKYALFVTYSKMYTLEIPDLRDVLNGQVGFHNNYNLCHMRTIQWSEIVSNGTDAYYNYDFTAPERECPKCHESCTHGCWGEGPKNCQKFSKLTCSPQCAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEAVSKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDKMDKGGECVPCNGPCPKTCPGVTVLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPERREVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQCNEDGCWGAGTDQCLTCKNFNFNGTCIADCGYISNAYKFDNRTCKICHPECRTCNGAGADHCQECVHVRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRECFQRHPECNGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASEEHVNLLKLLAVCMSSQMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLPAYTSQDEKDLIRKLAPTTDGSEAIAKPDDYLQPKAAPGPSHRTDCTDEMPKLNRYCKDPSNKNSSTGDDERDSSAREVGVGNLRLDLPVDEDDYLMPTCQPGPNNNNNMNNPNQNNMAAVGVAAGYMDLIGVPVSVDNPEYLLNAQTLGVGESPIPTQTIGIPVMGGPGTMEVKVPMPGSEPTSSDHEYYNDTQRELQPLHRNRNTETRV", "length": 1426 }, "evidence": [ { "id": "HGNC:3432", "url": "https://alliancegenome.org/gene/HGNC:3432#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-121214-64", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-121214-64#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-030918-4", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-030918-4#orthology", "database": "AGR" }, { "id": "MGI:104771", "url": "https://alliancegenome.org/gene/MGI:104771#orthology", "database": "AGR" }, { "id": "RGD:620486", "url": "https://alliancegenome.org/gene/RGD:620486#orthology", "database": "AGR" }, { "id": "FB:FBgn0003731", "url": "https://alliancegenome.org/gene/FB:FBgn0003731#orthology", "database": "AGR" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P04626-1", "protein_name": "Receptor tyrosine-protein kinase erbB-2", "gene_name": "ERBB2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV", "length": 1255 }, "evidence": [ { "id": "FB:FBgn0003731", "url": "https://alliancegenome.org/gene/FB:FBgn0003731#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P06494-1", "protein_name": "Receptor tyrosine-protein kinase erbB-2", "gene_name": "Erbb2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MELAAWCRWGFLLALLPPGIAGTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYVPANASLSFLQDIQEVQGYMLIAHNQVKRVPLQRLRIVRGTQLFEDKYALAVLDNRDPQDNVAASTPGRTPEGLRELQLRSLTEILKGGVLIRGNPQLCYQDMVLWKDVFRKNNQLAPVDIDTNRSRACPPCAPACKDNHCWGESPEDCQILTGTICTSGCARCKGRLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMHNPEGRYTFGASCVTTCPYNYLSTEVGSCTLVCPPNNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLRGARAITSDNVQEFDGCKKIFGSLAFLPESFDGDPSSGIAPLRPEQLQVFETLEEITGYLYISAWPDSLRDLSVFQNLRIIRGRILHDGAYSLTLQGLGIHSLGLRSLRELGSGLALIHRNAHLCFVHTVPWDQLFRNPHQALLHSGNRPEEDLCVSSGLVCNSLCAHGHCWGPGPTQCVNCSHFLRGQECVEECRVWKGLPREYVSDKRCLPCHPECQPQNSSETCFGSEADQCAACAHYKDSSSCVARCPSGVKPDLSYMPIWKYPDEEGICQPCPINCTHSCVDLDERGCPAEQRASPVTFIIATVVGVLLFLILVVVVGILIKRRRQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPSSPMDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFSPDPTPGTGSTAHRRHRSSSTRSGGGELTLGLEPSEEGPPRSPLAPSEGAGSDVFDGDLAMGVTKGLQSLSPHDLSPLQRYSEDPTLPLPPETDGYVAPLACSPQPEYVNQSEVQPQPPLTPEGPLPPVRPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLVPREGTASPPHPSPAFSPAFDNLYYWDQNSSEQGPPPSNFEGTPTAENPEYLGLDVPV", "length": 1257 }, "evidence": [ { "id": "FB:FBgn0003731", "url": "https://alliancegenome.org/gene/FB:FBgn0003731#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P21860-1", "protein_name": "Receptor tyrosine-protein kinase erbB-3", "gene_name": "ERBB3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNGRSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLGGTFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEEDNLATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPRPVSLHPMPRGCLASESSEGHVTGSEAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDEDEEYEYMNRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDYEYMNRQRDGGGPGGDYAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARLKTLRSLEATDSAFDNPDYWHSRLFPKANAQRT", "length": 1342 }, "evidence": [ { "id": "FB:FBgn0003731", "url": "https://alliancegenome.org/gene/FB:FBgn0003731#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P70424-1", "protein_name": "Receptor tyrosine-protein kinase erbB-2", "gene_name": "Erbb2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MELAAWCRWGFLLALLSPGAAGTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPANASLSFLQDIQEVQGYMLIAHNRVKHVPLQRLRIVRGTQLFEDKYALAVLDNRDPLDNVTTAAPGRTPEGLRELQLRSLTEILKGGVLIRGNPQLCYQDMVLWKDVLRKNNQLAPVDMDTNRSRACPPCAPTCKDNHCWGESPEDCQILTGTICTSGCARCKGRLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALITYNTDTFESMLNPEGRYTFGASCVTTCPYNYLSTEVGSCTLVCPPNNQEVTAEDGTQRCEKCSKPCAGVCYGLGMEHLRGARAITSDNIQEFAGCKKIFGSLAFLPESFDGNPSSGVAPLKPEHLQVFETLEEITGYLYISAWPESFQDLSVFQNLRVIRGRILHDGAYSLTLQGLGIHSLGLRSLRELGSGLALIHRNTHLCFVNTVPWDQLFRNPHQALLHSGNRPEEACGLEGLVCNSLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVWKGLPREYVRGKHCLPCHPECQPQNSSETCYGSEADQCEACAHYKDSSSCVARCPSGVKPDLSYMPIWKYPDEEGICQPCPINCTHSCVDLDERGCPAEQRASPVTFIIATVVGVLLFLIIVVVIGILIKRRRQKIRKYTMRRLLQETELVEPLTPSGAVPNQAQMRILKETELRKLKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPSSPMDSTFYRSLLEDDDMGELVDAEEYLVPQQGFFSPDPALGTGSTAHRRHRSSSARSGGGELTLGLEPSEEEPPRSPLAPSEGAGSDVFDGDLAVGVTKGLQSLSPHDLSPLQRYSEDPTLPLPPETDGYVAPLACSPQPEYVNQPEVRPQSPLTPEGPPPPIRPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLAPRAGTASQPHPSPAFSPAFDNLYYWDQNSSEQGPPPSTFEGTPTAENPEYLGLDVPV", "length": 1256 }, "evidence": [ { "id": "FB:FBgn0003731", "url": "https://alliancegenome.org/gene/FB:FBgn0003731#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q01279-1", "protein_name": "Epidermal growth factor receptor", "gene_name": "Egfr", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRPSGTARTTLLVLLTALCAAGGALEEKKVCQGTSNRLTQLGTFEDHFLSLQRMYNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNALYENTYALAILSNYGTNRTGLRELPMRNLQEILIGAVRFSNNPILCNMDTIQWRDIVQNVFMSNMSMDLQSHPSSCPKCDPSCPNGSCWGGGEENCQKLTKIICAQQCSHRCRGRSPSDCCHNQCAAGCTGPRESDCLVCQKFQDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGPDYYEVEEDGIRKCKKCDGPCRKVCNGIGIGEFKDTLSINATNIKHFKYCTAISGDLHILPVAFKGDSFTRTPPLDPRELEILKTVKEITGFLLIQAWPDNWTDLHAFENLEIIRGRTKQHGQFSLAVVGLNITSLGLRSLKEISDGDVIISGNRNLCYANTINWKKLFGTPNQKTKIMNNRAEKDCKAVNHVCNPLCSSEGCWGPEPRDCVSCQNVSRGRECVEKCNILEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGIMGENNTLVWKYADANNVCHLCHANCTYGCAGPGLQGCEVWPSGPKIPSIATGIVGGLLFIVVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQAHLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPYGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASDISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELILEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMEDVVDADEYLIPQQGFFNSPSTSRTPLLSSLSATSNNSTVACINRNGSCRVKEDAFLQRYSSDPTGAVTEDNIDDAFLPVPEYVNQSVPKRPAGSVQNPVYHNQPLHPAPGRDLHYQNPHSNAVGNPEYLNTAQPTCLSSGFNSPALWIQKGSHQMSLDNPDYQQDFFPKETKPNGIFKGPTAENAEYLRVAPPSSEFIGA", "length": 1210 }, "evidence": [ { "id": "FB:FBgn0003731", "url": "https://alliancegenome.org/gene/FB:FBgn0003731#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q61526-1", "protein_name": "Receptor tyrosine-protein kinase erbB-3", "gene_name": "Erbb3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAIGTLQVLGFLLSLARGSEMGNSQAVCPGTLNGLSVTGDADNQYQTLYKLYEKCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSVLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRFTQLTEILLGGVYIEKNDKLCHMDTIDWRDIVRVPDAEIVVKNNGGNCPPCHEVCKGRCWGPGPEDCQILTKTICAPQCNGRCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPAPLVYNKLTFQLEPNPHIKYQYGGVCVASCPHNFVVDQTFCVRACPADKMEVDKNGLKMCEPCRGLCPKACEGTGSGSRYQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRVYISANQQLCYHHSLNWTRLLRGPAEERLDIKYNRPLGECVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSREGVCVTHCNVLQGEPREFVHEAHCFSCHPECQPMEGTSTCNGSGSDACARCAHFRDGPHCVNSCPHGILGAKGPIYKYPDAQNECRPCHENCTQGCKGPELQDCLGQAEVLMSKPHLVIAVTVGLTVIFLILGGSFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGIWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRETLGPQLLLNWGVQIAKGMYYLEEHSMVHRDLALRNVMLKSPSQVQVADFGVADLLPPDDKQLLHSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEIPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRASGPGIPPAAEPSALSTKELQDAELEPDLDLDLDVEVEEEGLATTLGSALSLPTGTLTRPRGSQSLLSPSSGYMPMNQSNLGEACLDSAVLGGREQFSRPISLHPIPRGRQTSESSEGHVTGSEAELQERVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDGNGYVMPDTHLRGTSSSREGTLSSVGLSSVLGTEEEDEDEEYEYMNRKRRGSPARPPRPGSLEELGYEYMDVGSDLSASLGSTQSCPLHPMAIVPSAGTTPDEDYEYMNRRRGAGGSGGDYAAMGACPAAEQGYEEMRAFQGPGHQAPHVRYARLKTLRSLEATDSAFDNPDYWHSRLFPKANAQRI", "length": 1339 }, "evidence": [ { "id": "FB:FBgn0003731", "url": "https://alliancegenome.org/gene/FB:FBgn0003731#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q61527-1", "protein_name": "Receptor tyrosine-protein kinase erbB-4", "gene_name": "Erbb4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKLATGLWVWGSLLMAAGTVQPSASQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSIREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNMTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIDAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRRAENCTAEGMVCNHLCSNDGCWGPGPDQCLSCRRFSRGKICIESCNLYDGEFREFENGSICVECDSQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADQDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIMALTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSRTRIDSNRSEIGHSPPPAYTPMSGNQFVYQDGGFATQQGMPMPYRATTSTIPEAPVAQGATAEMFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERNPRGELDEEGYMTPMHDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHSASSGPPKAEDEYVNEPLYLNTFANALGSAEYMKNSVLSVPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTMLPPPPYRHRNTVV", "length": 1308 }, "evidence": [ { "id": "HGNC:3432", "url": "https://alliancegenome.org/gene/HGNC:3432#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-121214-64", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-121214-64#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-030918-4", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-030918-4#orthology", "database": "AGR" }, { "id": "MGI:104771", "url": "https://alliancegenome.org/gene/MGI:104771#orthology", "database": "AGR" }, { "id": "RGD:620486", "url": "https://alliancegenome.org/gene/RGD:620486#orthology", "database": "AGR" }, { "id": "FB:FBgn0003731", "url": "https://alliancegenome.org/gene/FB:FBgn0003731#orthology", "database": "AGR" }, { "id": "Q15303", "url": "https://omabrowser.org/oma/group/Q15303/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q62799-1", "protein_name": "Receptor tyrosine-protein kinase erbB-3", "gene_name": "Erbb3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRATGTLQVLCFLLSLARGSEMGNSQAVCPGTLNGLSVTGDADNQYQTLYKLYEKCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSVLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLKFTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRVRGAEIVVKNNGANCPPCHEVCKGRCWGPGPDDCQILTKTICAPQCNGRCFGPNPNQCCHDECAGGCSGPQDTDCFACRRFNDSGACVPRCPEPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTFCVRACPPDKMEVDKHGLKMCEPCGGLCPKACEGTGSGSRYQTVDSSNIDGFVNCTKILGNLDFLITGLNVDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRVYISANQQLCYHHSLNWTRLLRGPSEERLDIKYDRPLGECLAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSREGVCVTHCNFLQGEPREFVHEAQCFSCHPECLPMEGTSTCNGSGSDACARCAHFRDGPHCVNSCPHGILGAKGPIYKYPDAQNECRPCHENCTQGCNGPELQDCLGQAEVLMSKPHLVIAVTVGLAVILMILGGSFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGIWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVKQHRETLGPQLLLNWGVQIAKGMYYLEEHSMVHRDLALRNVMLKSPSQVQVADFGVADLLPPDDKQLLHSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEIPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRASGPGTPPAAEPSVLTTKELQEAELEPELDLDLDLEAEEEGLATSLGSALSLPTGTLTRPRGSQSLLSPSSGYMPMNQSSLGEACLDSAVLGGREQFSRPISLHPIPRGRPASESSEGHVTGSEAELQEKVSVCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDGNGYVMPDTHLRGASSSREGTLSSVGLSSVLGTEEEDEDEEYEYMNRKRRGSPPRPPRPGSLEELGYEYMDVGSDLSASLGSTQSCPLHPMAIVPSAGTTPDEDYEYMNRRRGAGGAGGDYAAMGACPAAEQGYEEMRAFQGPGHHAPHVRYARLKTLRSLEATDSAFDNPDYWHSRLFPKANAQRT", "length": 1339 }, "evidence": [ { "id": "FB:FBgn0003731", "url": "https://alliancegenome.org/gene/FB:FBgn0003731#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q62956-1", "protein_name": "Receptor tyrosine-protein kinase erbB-4", "gene_name": "Erbb4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKLATGLWVWGSLLVAARTVQPSASQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSIREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNMTLVSTIGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIDAIDPEKLNVFRTVREITGFLNIQTWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTVNQRIVIRDNRRAENCTAEGMVCNHLCSNDGCWGPGPDQCLSCRRFSRGKICIESCNLYDGEFREFENGSICVECDSQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDVLQGANSFIFKYADQDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIMALTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASVDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYIVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSRTRIDSNRSEIGHSPPPAYTPMSGSQFVYQDGGFATQQGMPMPYTATTSTIPEAPVAQGATAEMFDDSCCNGTLRKPVVPHVQEDSSTQRYSADPTVFAPERNPRAELDEEGYMTPMHDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHSASSGPPKAEDEYVNEPLYLNTFTNALGNAEYMKNSLLSVPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTMLPPPPYRHRNTVV", "length": 1308 }, "evidence": [ { "id": "HGNC:3432", "url": "https://alliancegenome.org/gene/HGNC:3432#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-121214-64", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-121214-64#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-030918-4", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-030918-4#orthology", "database": "AGR" }, { "id": "MGI:104771", "url": "https://alliancegenome.org/gene/MGI:104771#orthology", "database": "AGR" }, { "id": "RGD:620486", "url": "https://alliancegenome.org/gene/RGD:620486#orthology", "database": "AGR" }, { "id": "FB:FBgn0003731", "url": "https://alliancegenome.org/gene/FB:FBgn0003731#orthology", "database": "AGR" }, { "id": "Q15303", "url": "https://omabrowser.org/oma/group/Q15303/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 9, "go_terms": [ { "name": "neuregulin receptor activity", "id": "GO:0038131", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038131", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "protein tyrosine kinase activity", "id": "GO:0004713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004713", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "epidermal growth factor receptor binding", "id": "GO:0005154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005154", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "transmembrane receptor protein tyrosine kinase activity", "id": "GO:0004714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004714", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "epidermal growth factor receptor activity", "id": "GO:0005006", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005006", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "GABA receptor binding", "id": "GO:0050811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050811", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 16, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "GABA-ergic synapse", "id": "GO:0098982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098982", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "neuromuscular junction", "id": "GO:0031594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031594", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "postsynaptic membrane", "id": "GO:0045211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045211", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "presynaptic membrane", "id": "GO:0042734", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042734", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "basal plasma membrane", "id": "GO:0009925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009925", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "postsynaptic density membrane", "id": "GO:0098839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098839", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 37, "go_terms": [ { "name": "central nervous system morphogenesis", "id": "GO:0021551", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021551", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "cardiac muscle tissue regeneration", "id": "GO:0061026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061026", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "positive regulation of protein phosphorylation", "id": "GO:0001934", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001934", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "cell surface receptor protein tyrosine kinase signaling pathway", "id": "GO:0007169", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007169", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "heart development", "id": "GO:0007507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "positive regulation of cell population proliferation", "id": "GO:0008284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "peptidyl-tyrosine phosphorylation", "id": "GO:0018108", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018108", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "positive regulation of MAPK cascade", "id": "GO:0043410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043410", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "positive regulation of ERK1 and ERK2 cascade", "id": "GO:0070374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070374", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "synapse assembly", "id": "GO:0007416", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007416", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "protein autophosphorylation", "id": "GO:0046777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046777", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "neural crest cell migration", "id": "GO:0001755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001755", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "epidermal growth factor receptor signaling pathway", "id": "GO:0007173", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007173", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "neuron differentiation", "id": "GO:0030182", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030182", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "regulation of cell migration", "id": "GO:0030334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030334", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "lactation", "id": "GO:0007595", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007595", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "positive regulation of receptor signaling pathway via JAK-STAT", "id": "GO:0046427", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046427", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "mammary gland epithelial cell differentiation", "id": "GO:0060644", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060644", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "mammary gland alveolus development", "id": "GO:0060749", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060749", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "positive regulation of epithelial cell proliferation", "id": "GO:0050679", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050679", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "positive regulation of tyrosine phosphorylation of STAT protein", "id": "GO:0042531", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042531", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "mitochondrial fragmentation involved in apoptotic process", "id": "GO:0043653", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043653", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "olfactory bulb interneuron differentiation", "id": "GO:0021889", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021889", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "embryonic pattern specification", "id": "GO:0009880", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009880", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "positive regulation of cardiac muscle cell proliferation", "id": "GO:0060045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060045", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "cell surface receptor signaling pathway via JAK-STAT", "id": "GO:0007259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007259", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "ERBB4 signaling pathway", "id": "GO:0038130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038130", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "ERBB4-ERBB4 signaling pathway", "id": "GO:0038138", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038138", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "neurotransmitter receptor localization to postsynaptic specialization membrane", "id": "GO:0099645", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099645", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" }, { "name": "ERBB2-ERBB4 signaling pathway", "id": "GO:0038135", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038135", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1044, "end_pos": 1046, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1108, "end_pos": 1110, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1190, "end_pos": 1192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1244, "end_pos": 1246, "annotation": "n_glycosylation_sequon" }, { "start_pos": 138, "end_pos": 140, "annotation": "n_glycosylation_sequon" }, { "start_pos": 174, "end_pos": 176, "annotation": "n_glycosylation_sequon" }, { "start_pos": 181, "end_pos": 183, "annotation": "n_glycosylation_sequon" }, { "start_pos": 253, "end_pos": 255, "annotation": "n_glycosylation_sequon" }, { "start_pos": 358, "end_pos": 360, "annotation": "n_glycosylation_sequon" }, { "start_pos": 410, "end_pos": 412, "annotation": "n_glycosylation_sequon" }, { "start_pos": 473, "end_pos": 475, "annotation": "n_glycosylation_sequon" }, { "start_pos": 495, "end_pos": 497, "annotation": "n_glycosylation_sequon" }, { "start_pos": 548, "end_pos": 550, "annotation": "n_glycosylation_sequon" }, { "start_pos": 576, "end_pos": 578, "annotation": "n_glycosylation_sequon" }, { "start_pos": 620, "end_pos": 622, "annotation": "n_glycosylation_sequon" }, { "start_pos": 754, "end_pos": 756, "annotation": "n_glycosylation_sequon" }, { "start_pos": 999, "end_pos": 1001, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Autophosphorylated on tyrosine residues in response to ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Ligands trigger phosphorylation at specific tyrosine residues, thereby creating binding sites for scaffold proteins and effectors. Constitutively phosphorylated at a basal level when overexpressed in heterologous systems; ligand binding leads to increased phosphorylation. Phosphorylation at Tyr-1035 is important for interaction with STAT1. Phosphorylation at Tyr-1056 is important for interaction with PIK3R1. Phosphorylation at Tyr-1242 is important for interaction with SHC1. Phosphorylation at Tyr-1188 may also contribute to the interaction with SHC1. Isoform JM-A CYT-2 is constitutively phosphorylated on tyrosine residues in a ligand-independent manner. E4ICD2 but not E4ICD1 is phosphorylated on tyrosine residues.", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" }, { "database": "PubMed", "id": "9168115", "url": "https://glygen.org/publication/PubMed/9168115" }, { "database": "PubMed", "id": "18721752", "url": "https://glygen.org/publication/PubMed/18721752" }, { "database": "PubMed", "id": "17486069", "url": "https://glygen.org/publication/PubMed/17486069" }, { "database": "PubMed", "id": "8617750", "url": "https://glygen.org/publication/PubMed/8617750" }, { "database": "PubMed", "id": "19098003", "url": "https://glygen.org/publication/PubMed/19098003" }, { "database": "PubMed", "id": "16251361", "url": "https://glygen.org/publication/PubMed/16251361" }, { "database": "PubMed", "id": "17120616", "url": "https://glygen.org/publication/PubMed/17120616" } ] }, { "annotation": "Isoform JM-A CYT-1 and isoform JM-A CYT-2 are processed by ADAM17. Proteolytic processing in response to ligand or 12-O-tetradecanoylphorbol-13-acetate stimulation results in the production of 120 kDa soluble receptor forms and intermediate membrane-anchored 80 kDa fragments (m80HER4), which are further processed by a presenilin-dependent gamma-secretase to release a cytoplasmic intracellular domain (E4ICD; E4ICD1/s80Cyt1 or E4ICD2/s80Cyt2, depending on the isoform). Membrane-anchored 80 kDa fragments of the processed isoform JM-A CYT-1 are more readily degraded by the proteasome than fragments of isoform JM-A CYT-2, suggesting a prevalence of E4ICD2 over E4ICD1. Isoform JM-B CYT-1 and isoform JM-B CYT-2 lack the ADAM17 cleavage site and are not processed by ADAM17, precluding further processing by gamma-secretase.", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" }, { "database": "PubMed", "id": "9334263", "url": "https://glygen.org/publication/PubMed/9334263" }, { "database": "PubMed", "id": "10744726", "url": "https://glygen.org/publication/PubMed/10744726" }, { "database": "PubMed", "id": "12807903", "url": "https://glygen.org/publication/PubMed/12807903" }, { "database": "PubMed", "id": "17638867", "url": "https://glygen.org/publication/PubMed/17638867" }, { "database": "PubMed", "id": "16837552", "url": "https://glygen.org/publication/PubMed/16837552" }, { "database": "PubMed", "id": "15746097", "url": "https://glygen.org/publication/PubMed/15746097" } ] }, { "annotation": "Ubiquitinated. During mitosis, the ERBB4 intracellular domain is ubiquitinated by the APC/C complex and targeted to proteasomal degradation. Isoform JM-A CYT-1 and isoform JM-B CYT-1 are ubiquitinated by WWP1. The ERBB4 intracellular domain (E4ICD1) is ubiquitinated, and this involves NEDD4.", "evidence": [ { "database": "UniProtKB", "id": "Q15303", "url": "https://www.uniprot.org/uniprotkb/Q15303" }, { "database": "PubMed", "id": "19193720", "url": "https://glygen.org/publication/PubMed/19193720" }, { "database": "PubMed", "id": "17638867", "url": "https://glygen.org/publication/PubMed/17638867" } ] } ], "interactions": [], "reactions": [ { "id": "10596", "name": "", "equation": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00519-1", "Q07912-1", "P42684-1", "P10721-1", "P08069-1", "P06239-1", "O15146-1", "Q9UF33-1", "P08922-1", "Q9UM73-1", "P42679-1", "Q12866-1", "P07947-1", "P51451-1", "P49760-1", "P49761-1", "Q9HAZ1-1", "Q06187-1", "P49759-1", "P51813-1", "P07333-1", "Q9UIG0-1", "Q6XUX3-1", "P22607-1", "P00533-1", "Q9Y463-1", "P29317-1", "P21802-1", "Q9NR20-1", "Q13627-1", "P11362-1", "P42685-1", "Q16832-1", "Q15375-1", "P29323-1", "P22455-1", "P16591-1", "P07332-1", "P29322-1", "P54756-1", "P29320-1", "Q08345-1", "Q92630-1", "Q05397-1", "P54753-1", "Q15303-1", "P36888-1", "P09769-1", "P04626-1", "P21860-1", "Q14289-1", "O43781-1", "P54764-1", "P19525-1", "P21709-1", "P54762-1", "P54760-1", "P06241-1", "P07948-1", "P52333-1", "P06213-1", "P14616-1", "Q05655-1", "Q08881-1", "P29376-1", "P23458-1", "P08581-1", "Q14680-1", "P43405-1", "O60674-1", "P08631-1", "P46734-1", "P45985-1", "Q02750-1", "P52564-1", "O14733-1", "Q13163-1", "P09619-1", "Q16288-1", "P36507-1", "Q16620-1", "Q504Y2-1", "P16234-1", "Q13882-1", "P04629-1", "Q01974-1", "Q06418-1", "P07949-1", "Q96KB5-1", "Q15569-1", "Q96S53-1", "Q6J9G0-1", "P42680-1", "P35916-2", "P0C1S8-1", "P17948-1", "P42681-1", "P35590-1", "Q13470-1", "P33981-1", "P12931-1", "P35968-1", "P30530-1", "P43403-1", "P29597-1", "O75716-1", "Q04912-1", "Q02763-1", "Q9H3Y6-1", "P30291-1", "O43353-1", "P35790-1", "P14618-1", "Q8IVH8-1", "Q9NZJ5-1", "Q5JZY3-1", "Q13043-1", "P42345-1", "P41240-1" ], "evidence": [ { "id": "10596", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10596" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "O14733", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "O14733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O14733" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "O14733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O14733" } ] } ] }, { "uniprot_ac": "O15146", "gene_name": "MUSK", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "O15146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O15146" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "O15146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O15146" } ] } ] }, { "uniprot_ac": "O43353", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "O43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O43353" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "O43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O43353" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O43353" } ] } ] }, { "uniprot_ac": "O43781", "gene_name": "DYRK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "O43781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O43781" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "O43781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O43781" } ] } ] }, { "uniprot_ac": "O60674", "gene_name": "JAK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "O60674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O60674" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "O60674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O60674" } ] } ] }, { "uniprot_ac": "O75716", "gene_name": "STK16", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "O75716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O75716" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "O75716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O75716" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O75716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O75716" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "O75716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O75716" } ] } ] }, { "uniprot_ac": "P00519", "gene_name": "ABL1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00519" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P00519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00519" } ] } ] }, { "uniprot_ac": "P00533", "gene_name": "EGFR", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00533" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P00533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00533" } ] } ] }, { "uniprot_ac": "P04626", "gene_name": "ERBB2", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04626", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04626" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P04626", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04626" } ] } ] }, { "uniprot_ac": "P04629", "gene_name": "NTRK1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04629", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04629" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P04629", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04629" } ] } ] }, { "uniprot_ac": "P06213", "gene_name": "INSR", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P06213", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P06213" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P06213", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P06213" } ] } ] }, { "uniprot_ac": "P06239", "gene_name": "LCK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P06239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P06239" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P06239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P06239" } ] } ] }, { "uniprot_ac": "P06241", "gene_name": "FYN", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P06241", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P06241" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P06241", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P06241" } ] } ] }, { "uniprot_ac": "P07332", "gene_name": "FES", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P07332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07332" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P07332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07332" } ] } ] }, { "uniprot_ac": "P07333", "gene_name": "CSF1R", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P07333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07333" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P07333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07333" } ] } ] }, { "uniprot_ac": "P07947", "gene_name": "YES1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P07947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07947" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P07947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07947" } ] } ] }, { "uniprot_ac": "P07948", "gene_name": "LYN", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P07948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07948" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P07948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07948" } ] } ] }, { "uniprot_ac": "P07949", "gene_name": "RET", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P07949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07949" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P07949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07949" } ] } ] }, { "uniprot_ac": "P08069", "gene_name": "IGF1R", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P08069", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08069" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P08069", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08069" } ] } ] }, { "uniprot_ac": "P08581", "gene_name": "MET", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P08581", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08581" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P08581", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08581" } ] } ] }, { "uniprot_ac": "P08631", "gene_name": "HCK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P08631", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08631" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P08631", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08631" } ] } ] }, { "uniprot_ac": "P08922", "gene_name": "ROS1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P08922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08922" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P08922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08922" } ] } ] }, { "uniprot_ac": "P09619", "gene_name": "PDGFRB", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P09619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09619" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P09619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09619" } ] } ] }, { "uniprot_ac": "P09769", "gene_name": "FGR", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P09769", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09769" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P09769", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09769" } ] } ] }, { "uniprot_ac": "P0C1S8", "gene_name": "WEE2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P0C1S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C1S8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P0C1S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C1S8" } ] } ] }, { "uniprot_ac": "P10721", "gene_name": "KIT", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P10721", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10721" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P10721", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10721" } ] } ] }, { "uniprot_ac": "P11362", "gene_name": "FGFR1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P11362", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11362" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P11362", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11362" } ] } ] }, { "uniprot_ac": "P12931", "gene_name": "SRC", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P12931", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P12931" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P12931", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P12931" } ] } ] }, { "uniprot_ac": "P14616", "gene_name": "INSRR", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P14616", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P14616" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P14616", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P14616" } ] } ] }, { "uniprot_ac": "P14618", "gene_name": "PKM", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P14618" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P14618" } ] }, { "ec_number": "2.7.1.40", "activity": "ITP + pyruvate = IDP + phosphoenolpyruvate + H(+).", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P14618" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P14618" } ] } ] }, { "uniprot_ac": "P16234", "gene_name": "PDGFRA", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P16234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16234" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P16234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16234" } ] } ] }, { "uniprot_ac": "P16591", "gene_name": "FER", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P16591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16591" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P16591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16591" } ] } ] }, { "uniprot_ac": "P17948", "gene_name": "FLT1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P17948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P17948" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P17948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P17948" } ] } ] }, { "uniprot_ac": "P19525", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P19525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19525" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P19525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19525" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P19525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19525" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P19525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19525" } ] } ] }, { "uniprot_ac": "P21709", "gene_name": "EPHA1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P21709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P21709" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P21709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P21709" } ] } ] }, { "uniprot_ac": "P21802", "gene_name": "FGFR2", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P21802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P21802" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P21802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P21802" } ] } ] }, { "uniprot_ac": "P21860", "gene_name": "ERBB3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P21860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P21860" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P21860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P21860" } ] } ] }, { "uniprot_ac": "P22455", "gene_name": "FGFR4", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P22455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P22455" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P22455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P22455" } ] } ] }, { "uniprot_ac": "P22607", "gene_name": "FGFR3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P22607", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P22607" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P22607", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P22607" } ] } ] }, { "uniprot_ac": "P23458", "gene_name": "JAK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P23458", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P23458" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P23458", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P23458" } ] } ] }, { "uniprot_ac": "P29317", "gene_name": "EPHA2", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P29317", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P29317" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29317", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P29317" } ] } ] }, { "uniprot_ac": "P29320", "gene_name": "EPHA3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P29320", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P29320" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29320", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P29320" } ] } ] }, { "uniprot_ac": "P29322", "gene_name": "EPHA8", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P29322", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P29322" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29322", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P29322" } ] } ] }, { "uniprot_ac": "P29323", "gene_name": "EPHB2", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P29323", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P29323" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29323", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P29323" } ] } ] }, { "uniprot_ac": "P29376", "gene_name": "LTK", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P29376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P29376" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P29376" } ] } ] }, { "uniprot_ac": "P29597", "gene_name": "TYK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P29597", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P29597" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P29597", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P29597" } ] } ] }, { "uniprot_ac": "P30291", "gene_name": "WEE1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P30291", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P30291" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P30291", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P30291" } ] } ] }, { "uniprot_ac": "P30530", "gene_name": "AXL", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P30530", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P30530" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P30530", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P30530" } ] } ] }, { "uniprot_ac": "P33981", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P33981", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P33981" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P33981", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P33981" } ] } ] }, { "uniprot_ac": "P35590", "gene_name": "TIE1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35590", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35590" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35590", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35590" } ] } ] }, { "uniprot_ac": "P35790", "gene_name": "CHKA", "activity": [ { "ec_number": "2.7.1.32", "activity": "choline + ATP = phosphocholine + ADP + H(+).", "evidence": [ { "id": "P35790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35790" } ] }, { "ec_number": "2.7.1.82", "activity": "ethanolamine + ATP = phosphoethanolamine + ADP + H(+).", "evidence": [ { "id": "P35790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35790" } ] }, { "ec_number": "2.7.1.32", "activity": "", "evidence": [ { "id": "P35790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35790" } ] }, { "ec_number": "2.7.1.82", "activity": "", "evidence": [ { "id": "P35790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35790" } ] } ] }, { "uniprot_ac": "P35916", "gene_name": "FLT4", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35916", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35916" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35916", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35916" } ] } ] }, { "uniprot_ac": "P35968", "gene_name": "KDR", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35968", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35968" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35968", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35968" } ] } ] }, { "uniprot_ac": "P36507", "gene_name": "MAP2K2", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P36507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P36507" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P36507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P36507" } ] } ] }, { "uniprot_ac": "P36888", "gene_name": "FLT3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P36888", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P36888" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P36888", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P36888" } ] } ] }, { "uniprot_ac": "P41240", "gene_name": "CSK", "activity": [ { "ec_number": "2.7.10.4", "activity": "ATP + [a protein]-(L-tyrosine) = ADP + [a protein]-(L-tyrosine)-phosphate. The optimal peptide substrate contains the sequence (relative to the phosphorylated tyrosine): Glu-Glu-Asp/Glu-Ile-Tyr-Phe-Phe-Phe-Phe. Physiological substrates are C-terminal tail of Src-family protein kinases.", "evidence": [ { "id": "P41240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P41240" } ] }, { "ec_number": "2.7.10.4", "activity": "", "evidence": [ { "id": "P41240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P41240" } ] } ] }, { "uniprot_ac": "P42345", "gene_name": "MTOR", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P42345", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42345" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P42345", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42345" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P42345", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42345" } ] } ] }, { "uniprot_ac": "P42679", "gene_name": "MATK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P42679", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42679" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42679", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42679" } ] } ] }, { "uniprot_ac": "P42680", "gene_name": "TEC", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P42680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42680" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42680" } ] } ] }, { "uniprot_ac": "P42681", "gene_name": "TXK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P42681", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42681" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42681", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42681" } ] } ] }, { "uniprot_ac": "P42684", "gene_name": "ABL2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P42684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42684" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42684" } ] } ] }, { "uniprot_ac": "P42685", "gene_name": "FRK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P42685", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42685" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42685", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42685" } ] } ] }, { "uniprot_ac": "P43403", "gene_name": "ZAP70", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P43403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P43403" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P43403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P43403" } ] } ] }, { "uniprot_ac": "P43405", "gene_name": "SYK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P43405", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P43405" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P43405", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P43405" } ] } ] }, { "uniprot_ac": "P45985", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P45985", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P45985" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P45985", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P45985" } ] } ] }, { "uniprot_ac": "P46734", "gene_name": "MAP2K3", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46734" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P46734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46734" } ] } ] }, { "uniprot_ac": "P49759", "gene_name": "CLK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P49759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49759" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49759" } ] } ] }, { "uniprot_ac": "P49760", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P49760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49760" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49760" } ] } ] }, { "uniprot_ac": "P49761", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P49761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49761" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49761" } ] } ] }, { "uniprot_ac": "P51451", "gene_name": "BLK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P51451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P51451" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P51451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P51451" } ] } ] }, { "uniprot_ac": "P51813", "gene_name": "BMX", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P51813", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P51813" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P51813", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P51813" } ] } ] }, { "uniprot_ac": "P52333", "gene_name": "JAK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52333" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P52333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52333" } ] } ] }, { "uniprot_ac": "P52564", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52564", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52564" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P52564", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52564" } ] } ] }, { "uniprot_ac": "P54753", "gene_name": "EPHB3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P54753" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P54753" } ] } ] }, { "uniprot_ac": "P54756", "gene_name": "EPHA5", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P54756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P54756" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P54756" } ] } ] }, { "uniprot_ac": "P54760", "gene_name": "EPHB4", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P54760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P54760" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P54760" } ] } ] }, { "uniprot_ac": "P54762", "gene_name": "EPHB1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P54762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P54762" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P54762" } ] } ] }, { "uniprot_ac": "P54764", "gene_name": "EPHA4", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P54764", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P54764" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54764", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P54764" } ] } ] }, { "uniprot_ac": "Q01974", "gene_name": "ROR2", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01974", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01974" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q01974", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01974" } ] } ] }, { "uniprot_ac": "Q02750", "gene_name": "MAP2K1", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02750" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q02750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02750" } ] } ] }, { "uniprot_ac": "Q02763", "gene_name": "TEK", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02763" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q02763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02763" } ] } ] }, { "uniprot_ac": "Q04912", "gene_name": 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