[ { "uniprot_canonical_ac": "P25391-1", "uniprot_ac": "P25391", "uniprot_id": "LAMA1_HUMAN", "mass": { "chemical_mass": 337084.0, "monoisotopic_mass": 337084.0 }, "refseq": { "ac": "NP_005550", "name": "laminin subunit alpha-1 precursor", "summary": "This gene encodes one of the alpha 1 subunits of laminin. The laminins are a family of extracellular matrix glycoproteins that have a heterotrimeric structure consisting of an alpha, beta and gamma chain. These proteins make up a major component of the basement membrane and have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Mutations in this gene may be associated with Poretti-Boltshauser syndrome. [provided by RefSeq, Sep 2014].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005550" }, "gene_names": [ { "name": "LAMA1", "type": "recommended", "evidence": [ { "id": "P25391", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P25391" } ] }, { "name": "LAMA1", "type": "synonym", "evidence": [ { "id": "NP_005550", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005550" } ] }, { "name": "LAMA", "type": "synonym", "evidence": [ { "id": "NP_005550", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005550" }, { "id": "P25391", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P25391" } ] }, { "name": "PTBHS", "type": "synonym", "evidence": [ { "id": "NP_005550", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005550" } ] }, { "name": "S-LAM-alpha", "type": "synonym", "evidence": [ { "id": "NP_005550", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005550" } ] } ], "protein_names": [ { "name": "Laminin subunit alpha-1", "type": "recommended", "evidence": [ { "id": "P25391", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P25391/entry#names_and_taxonomy" } ] }, { "name": "Laminin A chain", "type": "synonym", "evidence": [ { "id": "P25391", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P25391/entry#names_and_taxonomy" } ] }, { "name": "Laminin-1 subunit alpha", "type": "synonym", "evidence": [ { "id": "P25391", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P25391/entry#names_and_taxonomy" } ] }, { "name": "Laminin-3 subunit alpha", "type": "synonym", "evidence": [ { "id": "P25391", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P25391/entry#names_and_taxonomy" } ] }, { "name": "S-LAM alpha", "type": "synonym", "evidence": [ { "id": "NP_005550", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005550" }, { "id": "P25391", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P25391/entry#names_and_taxonomy" } ] }, { "name": "S-laminin subunit alpha", "type": "synonym", "evidence": [ { "id": "NP_005550", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005550" }, { "id": "P25391", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P25391/entry#names_and_taxonomy" } ] }, { "name": "laminin A chain", "type": "synonym", "evidence": [ { "id": "NP_005550", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005550" } ] }, { "name": "laminin subunit alpha-1 precursor", "type": "synonym", "evidence": [ { "id": "NP_005550", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005550" } ] }, { "name": "laminin, alpha 1", "type": "synonym", "evidence": [ { "id": "NP_005550", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005550" } ] }, { "name": "laminin-3 subunit alpha", "type": "synonym", "evidence": [ { "id": "NP_005550", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005550" } ] } ], "function": [ { "annotation": "Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. As a ligand for alpha-dystroglycan, it is involved in a number of processes including epithelium branching morphogenesis, down-regulation of apoptotic signals in muscle via the activation of PI3K/AKT signaling, and activation of RAC1 signaling. As a subunit of laminin-1 (also known as laminin-111 or EHS laminin), it is involved in the stimulation of agrin-induced receptor clustering through a MuSK-independent pathway.", "evidence": [ { "database": "UniProtKB", "id": "P25391", "url": "https://www.uniprot.org/uniprotkb/P25391#function" }, { "database": "UniProtKB", "id": "P19137", "url": "https://www.uniprot.org/uniprotkb/P19137#function" } ] }, { "annotation": "Circular RNA hsa_circ_0000277 sequesters miR-4766-5p to upregulate LAMA1 and promote esophageal carcinoma progression. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_005550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005550" }, { "database": "PubMed", "id": "34226522", "url": "https://glygen.org/publication/PubMed/34226522" } ] }, { "annotation": "Spermatogonia Loss Correlates with LAMA 1 Expression in Human Prepubertal Testes Stored for Fertility Preservation. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_005550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005550" }, { "database": "PubMed", "id": "33513766", "url": "https://glygen.org/publication/PubMed/33513766" } ] }, { "annotation": "This gene encodes one of the alpha 1 subunits of laminin. The laminins are a family of extracellular matrix glycoproteins that have a heterotrimeric structure consisting of an alpha, beta and gamma chain. These proteins make up a major component of the basement membrane and have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Mutations in this gene may be associated with Poretti-Boltshauser syndrome. [provided by RefSeq, Sep 2014].", "evidence": [ { "database": "RefSeq", "id": "NP_005550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005550" } ] }, { "annotation": "Variability of retinopathy consequent upon novel mutations in LAMA1.", "evidence": [ { "database": "RefSeq", "id": "NP_005550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005550" }, { "database": "PubMed", "id": "35616092", "url": "https://glygen.org/publication/PubMed/35616092" } ] } ], "disease": [ { "disease_id": "DOID:9884", "recommended_name": { "id": "DOID:9884", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9884", "name": "muscular dystrophy", "description": "A myopathy is characterized by progressive skeletal muscle weakness degeneration." }, "synonyms": [ { "id": "MONDO:0008028", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008028", "name": "muscular dystrophy, Barnes type", "description": "" }, { "id": "MONDO:0008028", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008028", "name": "muscular dystrophy, Barnes type", "description": "" }, { "id": "MONDO:0008034", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008034", "name": "muscular dystrophy, pseudohypertrophic, with Internalized capillaries", "description": "" }, { "id": "MONDO:0008034", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008034", "name": "muscular dystrophy, pseudohypertrophic, with Internalized capillaries", "description": "" }, { "id": "MONDO:0010675", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010675", "name": "muscular dystrophy, cardiac type", "description": "" }, { "id": "MONDO:0010675", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010675", "name": "muscular dystrophy, cardiac type", "description": "" }, { "id": "MONDO:0010676", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010676", "name": "muscular dystrophy, Hemizygous lethal type", "description": "" }, { "id": "MONDO:0010676", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010676", "name": "muscular dystrophy, Hemizygous lethal type", "description": "" }, { "id": "MONDO:0010677", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010677", "name": "muscular dystrophy, Mabry type", "description": "" }, { "id": "MONDO:0010677", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010677", "name": "muscular dystrophy, Mabry type", "description": "" }, { "id": "MONDO:0010678", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010678", "name": "muscular dystrophy, progressive Pectorodorsal", "description": "" }, { "id": "MONDO:0010678", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010678", "name": "muscular dystrophy, progressive Pectorodorsal", "description": "" }, { "id": "MONDO:0010884", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010884", "name": "muscular dystrophy, scapulohumeral", "description": "" }, { "id": "MONDO:0010884", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010884", "name": "muscular dystrophy, scapulohumeral", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "9884", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9884" } ] }, { "disease_id": "MONDO:0014419", "recommended_name": { "id": "MONDO:0014419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014419", "name": "ataxia - intellectual disability - oculomotor apraxia - cerebellar cysts syndrome", "description": "Ataxia-intellectual disability-oculomotor apraxia-cerebellar cysts syndrome is a rare neuro-ophthalmological disease characterized by nonprogressive cerebellar ataxia, delayed motor and language development, and intellectual disability in addition to ophthalmological abnormalities (e.g. oculomotor apraxia, strabismus, amblyopia, retinal dystrophy, and myopia). Cerebellar cysts, cerebellar dysplasia and cerebellar vermis hypoplasia, seen on magnetic resonance imaging, are also characteristic of the disease." }, "synonyms": [ { "id": "MONDO:0014419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014419", "name": "Poretti-Boltshauser syndrome", "description": "" }, { "id": "MONDO:0014419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014419", "name": "ataxia - intellectual disability - oculomotor apraxia - cerebellar cysts syndrome", "description": "" }, { "id": "MONDO:0014419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014419", "name": "PORETTI-Boltshauser syndrome", "description": "" }, { "id": "MONDO:0014419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014419", "name": "PTBHS", "description": "" }, { "id": "MIM:615960", "resource": "MIM", "url": "https://www.omim.org/entry/615960", "name": "Poretti-Boltshauser syndrome", "description": "Poretti-Boltshauser syndrome" } ], "unlinked_id_list": [], "evidence": [ { "id": "615960", "database": "MIM", "url": "https://www.omim.org/entry/615960" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "72.79", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000101680", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101680" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "41.27", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000101680", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101680" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "48.43", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000101680", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101680" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "51.95", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000101680", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101680" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "80.7", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000101680", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101680" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "52.04", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000101680", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101680" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "76.08", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000101680", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101680" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "49.93", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000101680", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101680" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "63.24", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000101680", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101680" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "72.37", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000101680", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101680" } ] } ], "expression_disease": [ { "significant": "No", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P25391", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P25391" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] } ] }, { "significant": "No", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P25391", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P25391" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "P25391", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P25391" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "11054", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11054" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Head and neck cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "P25391", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P25391" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ], "unlinked_id_list": [ "DOID:1542" ], "evidence": [ { "id": "11934", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11934" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Lung cancer [DO disease 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"https://www.ebi.ac.uk/interpro/entry/IPR001791", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002049", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002049", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008211", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008211", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010307", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010307", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050440", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050440", "database": "InterPro", "categories": [ "Protein 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"PTHR10574:SF409", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10574:SF409", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00052", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00052", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF00053", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00053", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF00054", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00054", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF00055", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00055", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF06008", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06008", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF06009", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06009", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "PF24973", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24973", "database": "Pfam", "categories": [ "Other", "Protein Classification" ] }, { "id": "P25391", "url": "https://pharos.nih.gov/targets/P25391", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR:P25391", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:P25391", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-3000157", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000157", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-HSA-3000171", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000171", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-HSA-373760", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-373760", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-HSA-8874081", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8874081", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-HSA-9638630", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9638630", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-HSA-9913351", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9913351", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-HSA-9925563", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9925563", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_005550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005550", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "P25391", "url": "https://www.uniprot.org/uniprotkb/P25391", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P25391-1", "url": "https://www.uniprot.org/uniprotkb/P25391-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": 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"length": 3075, "header": "sp|P25391-1|LAMA1_HUMAN Isoform 1 of Laminin subunit alpha-1 OS=Homo sapiens OX=9606 GN=LAMA1 PE=1 SV=2 CANONICAL=P25391-1" }, "isoforms": [ { "isoform_ac": "P25391-1", "url": "https://www.uniprot.org/uniprotkb/P25391/entry#P25391-1", "sequence": { "sequence": 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"DOI", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "id": "GLY_000888", "database": "Data Submission", "url": "http://data.glygen.org/GLY_000888" } ], "filter_code": "00100000000000000000.0000000.00010000000000.0100000.1100000000.110111110111111110.00010.01001" }, { "glytoucan_ac": "G80920RR", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "PLVAPCVPCSCNNHSDTCDPNTGK", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1407, "start_aa": "Asn", "end_pos": 1407, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1407", "evidence": [ { "id": "10.1101/2023.09.13.557529", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "id": "GLY_000888", "database": "Data Submission", "url": "http://data.glygen.org/GLY_000888" } ], "filter_code": "00100000000000000000.0000000.00010000000000.0100000.1100000000.110111110111111110.00010.01001" }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 1579, "start_aa": "Asn", "end_pos": 1579, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1579", "evidence": [ { "id": "P25391", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P25391#ptm_processing" } ], "filter_code": "00100000000000000000.00010000000000.0.01001" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 166, "start_aa": "Thr", "end_pos": 166, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr166", "evidence": [ { "id": "GLY_001151", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001151" } ], "filter_code": "00000000000000001000.00000000001000.0.01001" }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 1689, "start_aa": "Asn", "end_pos": 1689, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1689", "evidence": [ { "id": "P25391", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P25391#ptm_processing" } ], "filter_code": "00100000000000000000.00010000000000.0.01001" }, { "glytoucan_ac": "G27915IV", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { 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"MESMCAHKQCYLESRILSHCFRAGKENIHRQRSAQRIHFRYFSNFPQRIKMKFYVKTTLYIGPAAHFNWVDPRQQLRGLQRSGSAPARMPAAGGILLLLLLGILEGSQTQRPQQRRQSPAHQQRGLFPAVLNLASNALITTNATCGEKGPEMYCKLVEHVPGQPVRNPQCRICNQNSSHPYQRHPITNAIDGKNTWWQSPSIKNGVEYHYVTITLDLQQVFQIAYVIVKAANSPRPGNWILERSLDDEEYKPWQYHAVTDTECLTLYNIYPRTGPPSYAKDDEVICTSFYSKIHPLENGEIHISLINGRPSADDPSPELLEFTSARYIRLRFQRIRTLNADLMMFAHKDPREIDPIVTRRYYYSVKDISVGGMCICYGHARACPLDPATNKSRCECEHNTCGESCDRCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDETVASRNLSLNIHGKYIGGGVCINCTHNTAGINCETCIDGFFRPKGVSPSYPRPCQPCHCDPAGSLSEVCIKDEKHTRRGLKPGSCYCKPGFGGMNCDRCVRGYRGYPDCQPCNCSGLGSTNQDPCIGPCSCKENVEGEDCSHCKFGFFNLQEENQKGCEECFCSGVSDRCQSSYWTYGNIQDMHGWYLTDLSGRIQVAPQLDNPDAPQQISVSNSEARRSLPDSYYWSAPAPYLRNKLPAVGGQLSFTISYDLEEEEDDTEKILQLMIILEGNNLRISTAYKEVHLEPSEEHVEELSLKEESFTIHGTNLPVSRKDFMILLTNLERVLIQTTYNLGMDVIFRLSSVNLESAVPYPTDRSIASAVEVCQCPPGYSGSSCEACWPRHRRVNGTIFGGLCEPCQCFGHAEACNDVTGECLSCKDHTGGPYCNECLPGFYGDPTRGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDECPVGYTGPRCERCAEGYFGQPSIPGGSCQPCLCNDNLDFSIPGSCDSLSGSCLICKPGTTGRFCELCADGYFGDAVDAKNCQPCRCNVNGSFSEICHRKTGQCECRPNVQGQRCDECKPETFGLQLGRGCIPCNCNSFGSKSFDCEASGQCWCQPGVAGKKCDRCAHGYFNFQEGGCTACDCSHLGNNCNPKTGQCICPPNTIGEKCSECLPNTWGHSIVTGCKVCNCSTVGSLSSQCNINTGQCSCHPKFSGMKCSECNRGHWNYPLCSLCDCFLPGTDATTCDSETRKCSCSDQTGQCTCKVNVEGVHCDRCRPGKFGLEAKNPLGCSSCYCFGVTSQCSEAKGLVRTWVTLRDEQTILPLVDEALQHTTTKGIAFQNPEIVAKMDEVRQDLHLEPFYWKLPEQFEGKKLMAYGGKLKYTIYFEARDETGFATYKPQVIIRGGTPTHARIITRHMAAPLIGQLTRHEIEMTEKEWKYYGDDPRISRTVTREDFLDILYDIHYILIKATYGNVVRQSRISEISMEGAEPGQVSAASPLANLIERCDCPPGYSGLSCETCAPGFYRVHSEPGGRTPGPTLGTCVPCQCHGHSSQCDPETSVCQNCQHHTAGDFCERCALGYYGIVRGLPNDCQPCACPLISPSNNFSPSCVLEGLEDYRCTACPRGYEGQYCERCAPGYAGSPSSPGGSCQECECDPYGSLPVPCDPVTGLCTCRPGATGRKCDGCEHGHAREGAECVFCGDECTGLLLGDLAHLEQMAMNINLTGPLPAPYKILYGLENATQELKHLLSPQRAPERLLQLAEGNMNTLVMEMNELLTRATKVTADGEQTGQDAERTNSRAQSLEEFIKGLVQHAEAVNEKAIKLNETLGSQDRTAERNLQELQKEIDRMLKELRSKDLQTQKEVAEDELVAAEGLLKRVNKLFGEPRAQNEEMEKDLREKLAEYQNKLDDAWDLLREATKKTKDADRLSAANQKNMTILETKKEAIEGSKRQIENTLKEGNDILDEANRLAGEITSVIDYVEDIKTKLPPMSEELSDKIDDLAQEIKDRRLAEKVFQAESHAAQLNDSSAVLDGILDEAKNISFNATAAFRAYSNIKDYIDEAEKVAREAKELAHEATKLATSPQGLLKEDAKGSLQKSFRILNEAKKLANDVKENHNDLSGLKTRLETADLRNSGLLGALNDTMDKLSAIPNDTAAKLQAVKEKAREANDTAKAVLAQVKDLHQNLDGLKQNYNKLADSVAKTNAVVKDPSKNIADAGATVRNLEQEADRLIDKLKPIKELEDNLKKNISEIKELINQARKQANSIKVSVSSGGDCIRTYKPEIKKGSYNNIVVHVKTAVADNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTIDDSYWYRIEASRTGRNGSISVRALDGPKASMVPSTHHSVSPPGYTILDVDANAMLFVGGLTGKIKKADAVRVTTFTGCMGETYFDNKPIGLWNFREKEGDCKGCTVSPQVEDSEGTIQFDGEGYALVSRPIRWYPNISTVMFKFRTFSSNALLMYLATRDLKDFMSVELSDGHVKVSYDLGSGMASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDSNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLRNLRPEVNVKKYSGCLKDIEISRTPYNILSSPNYVGVTKGCSLENVYTVSFPKPGFVELAAVSIDVGTEINLSFSTRNESGIILLGSGGTLTPPRRKRRQTTQAYYAIFLNKGRLEVHLSSGTRTMRKIVIKPEPNLFHDGREHSVHVERTRGVFTVQVDENRRHMQNLTEEQPIEVKKLFVGGAPPEFQPSPLRNIPAFQGCVWNLVINSIPMDFAQPIAFKNADIGRCAYQKPREEEDDAVPAEVTVQPQPVPTPAFPFPAPTMVHGPCVAESEPAFLSGSKQFGLSRNSHIALAFDDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLRNGFPYFSYDLGSGDTSTMIPTRINDGQWHKIKITRVKQEGILSVDDASNQTISPKKADILDVVGILYVGGLPINYTTRRIGPVTYSLDGCVRNLYMEQAPVDLDQPTSSFHVGTCFANAEKGTYFDGTGFAKAVGGFKVGLDLLVEFEFRTTRPTGVLLGVSSQKMDGMGIEMIDEKLMFHVDNGAGRFTAVYDAGSPGHMCDGRWHKVTAKKIKNRLELVVDGNQVDAQSPNAASTSADTNDPVFVGGFPDGLNQFGLTTNVRFRGCIRSLKLTKGTGKPLEVNFAKALELRGVQPVSCPTT", "length": 3203 }, "evidence": [ { "id": "FB:FBgn0261563", "url": "https://alliancegenome.org/gene/FB:FBgn0261563#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0X4B6-1", "protein_name": "Laminin subunit alpha-1", "gene_name": "LAMA1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGGEAHLKSLQSSEIQLLRSQECKFKGWRKRTGLFPAILNLASNAHISTNATCGEKGPEMFCKLVEHVPGRPLRNSQCRVCDRHSANPKEQHPISSAIDGTNNWWQSPSIQNGRQYHWVTITLDLRQVFQVAYVIIKSANAPRPGNWILERSIDGTEFKPWQYYAISDTECLTRYNITPRVGPPTYKRDDEVICTSYYSRLVPLEHGEIHTSLINGRPSADDPSQKLLDFTSARYIRLRLQRIRTLNADLMTLSHHDPKELDPIVTRRYYYSIKDISVGGMCICYGHARSCPLDEITKKLQCQCEHNTCGESCNRCCPGYHQKPWRPGTISAGNKCEKCNCHNKAEDCYYNQTIADQKRSMNIHGQYTGGGVCLNCSQHTTGINCEMCADGYFRPQKVSPYDDHPCYPCGCDPFGSLSSVCVKDERQSDSQHGTWPGQCQCRDGYTGEKCDRCAFGYRGYPNCLRCNCSLIGSINEDPCAEPCLCKENVEGENCDLCKPGFYNLQERNPEGCTECFCFGVSDVCDSLTWPISQISDMTGWLITDLYNAKGVQPQRGQFDGPRQISINNSDAVKVLKHTYYWSAPEPYLGNKLTAFGGDLKYTVSYDIPMESVDSDILSSVDVIIQGSGQILSTRAAGLSLQPYEEYSNSVRLVSENFIDFNTKKAIDRERLMTVLVNVTRLLIRANYNIAKKAVYRLDSVTLDNASANVIDLSSAPDVEFCECPQGYTGISCESCLPGYYRVDGILFGGICQPCKCNGHATECDTQGVCFACQHNTTGPFCDQCLPGFYGSPSQGTPEDCQPCACPLSSAANNFSPTCQLSEGEGIVCDKCLPGYTGSQCERCANGYYGNPLVPGQSCVPCECNGNVNPQEDGYCDTITGQCLKCVGNTAGLHCEKCADGYYGDAVTEKSCRACECHVNGSLSSVCHHETGICDCKSDVIGQKCDKCLNGFYGLLTGLGCIPCNCSQFGSISEDCNHQGQCHCLPGVAGEKCDRCAHGFHSLQKSGCTPCDCAHTQNNCNADSGQCICPPHTRGPKCDLCEENHWGLSPKLGCKACNCSDSGSDSLQCDVLTGQCQCKAEFGGQNCSRCALGYRDYPDCVACDCDLSGTKAEMCDDTKGLCGCEEETGICACKENVFGLQCSECKPGTFALSANNALGCTPCFCFGMSTSCLEVEDHVRIPITLTPDQSILHVVAQSNLTGTVEGVFSQFPDVLLDAAIVRKYLNTETFYWRLPEQFQGDQLMAYGGKLRYTVAFYALDGFGTSNFEPQILMKGGRTSKLVIYVDSPSPENGIRSEKEVEMKEDSWKYFNSVSDQPVSRSDFMSVLSNIEYILIKAAYGQGLQQSRIANISMEIAVKFEEMHLGRSRAHLIEQCRCPAGYAGFSCQNCAPGYYREKPKEFSVRETHTIIAPCVPCQCNNHSETCDPETGKCLNCRDNTVGDYCSACAPGYYGKVIGSVNDCSLCACPRANPVSFSPTCVLKGVQDYHCDACLPGYEGQYCEKCSLGYYGDPQLPGGSCHLCQCNPSGSVHVNCDRVTGKCPCKQGVTGQLCEECEPRHLLLEEECVSCDDNCTGVLLNNLDSLSENILSLNLTGVVHVPSGILSELENATKHLKGFIVLREDRTYSLATAGQSLLNLSRDVDQLPEESSRILRKASQLNTMTQETRSKSKELSGFIDTVHTAIKVLAEVAMSLNETLGLGLPLSNVSSQSLQDDISTQLDELRKKDFVRRHYNATSVLKAAEGLLHWVQKDYLKPQQELAELKKDASQLLSKHNSKLQDAQDLLNDALANINETNRLFPLISSNLGELNEKKLSIKESKEVSTMLIKEGKFLVNAAAALSQDVKNSTTNLEVHQDELLQWNTNLRHHVDELVMQMSVRGVLDLVYRAEDHAAQFQRLADALESGLSKVKDVTLNATAAVYTHSSVKNVIERTESLADDASRVVNGPLDLPDESLGLLGKDTLQLSSKVQNEAKNLKKKSNGLLSELNGLSKKVEKIQESTVKIVSHLNDSLLALKALPNGTRKYMLEVKELAVSANTSAMVGLSHFEDFSQKLLNTSSTLSQVNGTLRKTSELITDSSKAAMMAEKQVKEMEAQASLLLDRLKPLKTLEENLSRNLSEIKELISQARKQAASIKVAVSADRDCVRAYQPQISSTNYNSLTLNVKTTEPDNLLFYLGSNGKTDFLAVEMRRGKVALLWDLGSGSTRVEYPDFQIDNNKWHRIHATRFGKTGTLTIEEMNSNQKSSPKSATSPGTASILDVNKSTLMFIGGLGGQIKKSPAVKVTHFKGCMGEASLNGKSIGLWNYIEREGKCSGCFGSPQDEDTSFHFDGRGYSVVEKALRSTVTQIIIFFSTFSPNGLLLYLASNGTRDFLSLELVDGKVRLTVDLGSGPLALTTENRYNNGTWYKISFSRNKKQGMLAVMDAYNLNYKETKQGEAPGVASDLNRSDKDPIFIGGLPKSRAVRKGLNSRMYVGCIKNLEISRSTFDLLRNSYGVRKGCVLEPIRSMNILTNGYIELEPKSLSPESELMATFATKNSNGIILAGLSRGLEKRRRRQAHLPFFSIMLIDGHLAVHVNAGDRASTRKVILRSPNGTYSDGQEHSVILIRNKRIITVQVDESNPSELRLGSSAEMSPMNISNFYAGGIPAGEDFFGLKMTGSFYGCISNLIFNKELLDFTTSMKYEHVDMDSCFLSEKPKAAMQLEDMEIQAELPVPLRPPTDTKKLVACAKDELPGHVQGAHQFGLAKGSHLTLLFNQTAVRKKLSVQLNLRTFASSGLIYYMAHQNQIDYAALQLLRGQLYFSFDLGKGRAVASHPAIVNDGKWHTIRTEYVKRKGIIIVDGQELVSVSALGDGSTLDVEGKLYVGGLPIDYVAKNLGNVTHSIPACIGSMTINSKQLDKESPVSIFAVNKCYATVQDGTFFDGSGFAALVRDGYKVRSDVNITLEFRTTAMHGVLLGISSAKVDAIGLEIVNGKVLFHVNNGAGRITATYEPGVANSLCDGKWHKLQANTSKYRISLIIDGNLVQTDNPYIQSTSADTNNPIYVGGYPGDVKQNCLTSKSSFHGCLRNLVLTRGQQAELFDFSRAFDLRGVFPHSCPGAQQ", "length": 3100 }, "evidence": [ { "id": "P25391", "url": "https://omabrowser.org/oma/group/P25391/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4A409-1", "protein_name": "Basement membrane-specific heparan sulfate proteoglycan core protein", "gene_name": "Lama1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRGSGTGVALLVLLASVLWVTVRSQQRGLFPAILNLATNAHISANATCGEKGPEMFCKLVEHVPGRPVRHAQCRVCDGNSTNPRERHPITHAIDGTNNWWQSPSIQNGREYHWVTVTLDLRQVFQVAYVIIKAANAPRPGNWILERSVDGVKFRPWQYYAVSDTECLTRYKITPRRGPPTYRADNEVICTSYYSKLVPLEHGEIHTSLINGRPSADDPSPQLLEFTSARYIRLRLQRIRTLNADLMTLSHRDLRDLDPIVTRRYYYSIKDISVGGMCICSGHASSCPWDEEAKQLQCQCEHNTCGESCDRCCPGFHQQPWRPGTISSSNQCEECNCHNKAKDCYYDNNVAKERKSLNTAGQYSGGGVCINCLQNTTGINCETCIDQYYRPHKVSPYEDQPCRPCDCDPVGSLSSVCIKDDLHADLANGKWPGQCPCRKGYAGDKCDRCQFGYRGFPNCVPCDCSTVGSVNEDPCTEPCLCKKNVEGENCDRCKPGFYNLKERNPEGCSECFCFGVSDVCDSLTWSVSQVTNMSGWLVTDLISPNKIRSQQDALGRHRQISINNTAVMHRFTSPYYWAAPEAYLGNKLTAFGGFLKYTVSYDIPVETVDSNLMSHADVIIKGNGLTISTRAEGLSLQPYEEYFNVVRLVPENFRDFNTRREIDRDQLMTVLANVTHLLIRANYNSAKMALYRLDSVSLDIASPNAIDLVVAADVEHCECPQGYTGTSCEACLPGYYRVDGILFGGICQPCECHGHSSECDIHGICSGCTHNTTGDHCEQCLPGFYGTPSRGTPGDCQPCACPLSIDSNNFSPTCHLTDREEVVCDQCAPGYSGAWCERCADGYYGNPTVPGGTCVPCNCSGNVDPLEAGHCDSVTGECLKCLWNTDGAHCERCADGFYGDAVTAKNCRACNCHENGSLSGICHLETGLCDCKPYVTGQQCDQCLPGYYGLDTGLGCVPCNCSGEGSISDNCTEEGQCHCVPGVSGKQCDQCSHGFYAFQNGGCTPCDCAHTQNNCDPDSGECLCPPHTHGLKCEQCEEAFWGLDPEQGCQACNCSVVGSTSPQCDVLSGQCSCKEGFGGQSCHQCSLGYRSFPDCVPCDCDLRGTLADTCDLEQGLCSCTEDSGTCSCKENVLGPQCDKCRAGTFALRADNPLGCSPCFCFGLSQLCSELEGYVRAPITLASDQPILHVVSQSNLKGTTEGVHFQPPDTLLDAEAVRQHIYAEPFYWRLPKQFQGDQLLAYGGKLQYTVAFYSTLGTGTSNYEPQVLIKGGRTRKHIIYMDAPAPENGVRQDYEVGMKEEFWKYFNSVSEKHVTHSDFMSVLSNIEYILIKASYGQGLQQSRIANISMEVGRKAVEPAPEGKVALQLELCVCPPGTAGHSCQDCAPGYHRGKLPESSGRGPRPLLAPCVPCNCNNHSDVCDPETGKCLNCRDHTAGDHCELCTAGYYGKVIGLPGDCTPCTCPHHPPFSFSPTCVLEGDSGFWCDACLPGYEGQYCERCSAGYHGNPRAAGGSCQKCDCNPQGSVHSDCDRASGQCVCKPGATGLHCEECLPRHILMESHCVSCDDECVGALLNDLDSIGDAVLSLNLAGVSLAPYGTLENLENTTKYFQGYLLEENAKKVQAEIQLGGIEEQTENLQKELARVLRSHQQVNTAMERTSNRSQALATFLEQLHRNIKEITEKVATLNQTTGEDFQPPVSALQSLHQNISSLLALIKKRNFTEMRQNATLELKAAKDLLSRIQKRFQKPQEKLKALKEASSLLSNHIADLQAAEELLREAGSKTQESSLLLLLVKANLKDFREKKLHVQEEQNLTSKLIAQGREWVDAARTHAAAAQDTLTQLEHHRDELLLWASKIRSHVDDLVMQMSKRRARDLVHRAEQHASELQSAAEALDRDLENVRNVSLNATSAVHVHTNIQTLTEEAESLAADAHKTANKTSLISESLAPRGKAVLQRSSRFVKESVSTRKKQQGITLKLDELKNLTSQFQERVDNITRQANDSLTVLRESPGGMREKSRKVKELAVAANETAARTLEDMLGLSLRVFNTSEDLSRVNATVQETKDLLHNSTMTTILAGRKMRDMEMQANLLFDRLKPLKMLEENLSRNLSEIKLLISRARKQAASIKVAVSADRDCIRAYQPQISSTNYNTLLLNVKTQEPDNLLFYLGSSSSSDFLAVEMRRGKAAFLWDLGSGSTRLEFPDVSINNDKWHSIYITRFGNMGSLSVKEASAAEDPPVRTSKSPGLANVLDINNSTLMFVGGLGGQIKKSPAVKVTHFKGCMGEAFLNGKSIGLWNYIEREGKCNGCFGSSQNEDASFHFDGSGYAVVEKALRPTVTQIIILFSTFSPNGLLFYLASNGTKDFLSIELLRGRVKVMVDLGSGPLTLMTDRRYNNGTWYKIAFQRNRKQGLLAVFDAYDTSDKETKQGETPGAASDLNRLEKDLIYVGGLPHSKAVRKGVSSRSYVGCIKNLEISRSTFDLLRNSYGVRKGCTLEPIQSVSFLKGGYMEMPPKSLSPESSLLATFATKNSSGVILAALGKDAEKAGASQAHVPFFSILLIEGRIEVHINSGDGTSLRKALLHAPTGSYSDGQEHSISVVRNRRVITVQLDENSPVEMKLGPLTEGRTINISNLYIGGLPEGKGTPMIRMRTSFHGCIKNVVIDAQLLDFTRAAGSEQVELDTCLLAEEPTQGLHREHGELPPEPPTLPEPELCAVDTAPGYVAGAHQFGLSQNSHLVLPFNQSDVRKRLQVQLNIRTFASSGLIYYVAHQNQMDYAVLQLHEGRLNFMFDLGKGRTKVSHPALLSDGKWHTVKTEYIKRKAFMTVDGQESPSVTVVGNATTLDVERKLYLGGLPAHYRARSIGTITHSIPACIGDVTVNSQQLDKDRPASAFAVDRCYAVAQEGTFFEGSGYAALVKEGYKVRLDLNITLEFRTSSKNGVLLGISSAKVDAIGLEIVDGKVSFHVNNGAGRITATYKPRATRTLCDGKWHTLHAHKSRHRIVLTVDGDAVRAESPHTHSTSADTNDPIYVGGYPAHVKQNCLSSRASFRGCVRNLELSRGSQVQSLDLSRAFDLHGVFPHSCPGPEP", "length": 3083 }, "evidence": [ { "id": "HGNC:6481", "url": "https://alliancegenome.org/gene/HGNC:6481#orthology", "database": "AGR" }, { "id": "MGI:99892", "url": "https://alliancegenome.org/gene/MGI:99892#orthology", "database": "AGR" }, { "id": "RGD:1307207", "url": "https://alliancegenome.org/gene/RGD:1307207#orthology", "database": "AGR" }, { "id": "FB:FBgn0261563", "url": "https://alliancegenome.org/gene/FB:FBgn0261563#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P19137-1", "protein_name": "Laminin subunit alpha-1", "gene_name": "Lama1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRGSGTGAALLVLLASVLWVTVRSQQRGLFPAILNLATNAHISANATCGEKGPEMFCKLVEHVPGRPVRHAQCRVCDGNSTNPRERHPISHAIDGTNNWWQSPSIQNGREYHWVTVTLDLRQVFQVAYIIIKAANAPRPGNWILERSVDGVKFKPWQYYAVSDTECLTRYKITPRRGPPTYRADNEVICTSYYSKLVPLEHGEIHTSLINGRPSADDPSPQLLEFTSARYIRLRLQRIRTLNADLMTLSHRDLRDLDPIVTRRYYYSIKDISVGGMCICYGHASSCPWDEEAKQLQCQCEHNTCGESCDRCCPGYHQQPWRPGTISSGNECEECNCHNKAKDCYYDSSVAKERRSLNTAGQYSGGGVCVNCSQNTTGINCETCIDQYYRPHKVSPYDDHPCRPCNCDPVGSLSSVCIKDDRHADLANGKWPGQCPCRKGYAGDKCDRCQFGYRGFPNCIPCDCRTVGSLNEDPCIEPCLCKKNVEGKNCDRCKPGFYNLKERNPEGCSECFCFGVSGVCDSLTWSISQVTNMSGWLVTDLMSTNKIRSQQDVLGGHRQISINNTAVMQRLTSTYYWAAPEAYLGNKLTAFGGFLKYTVSYDIPVETVDSDLMSHADIIIKGNGLTISTRAEGLSLQPYEEYFNVVRLVPENFRDFDTRREIDRDQLMTVLANVTHLLIRANYNSAKMALYRLDSVSLDIASPNAIDLAVAADVEHCECPQGYTGTSCEACLPGYYRVDGILFGGICQPCECHGHASECDIHGICSVCTHNTTGDHCEQCLPGFYGTPSRGTPGDCQPCACPLSIDSNNFSPTCHLTDGEEVVCDQCAPGYSGSWCERCADGYYGNPTVPGGTCVPCNCSGNVDPLEAGHCDSVTGECLKCLWNTDGAHCERCADGFYGDAVTAKNCRACDCHENGSLSGICHLETGLCDCKPHVTGQQCDQCLSGYYGLDTGLGCVPCNCSVEGSVSDNCTEEGQCHCGPGVSGKQCDRCSHGFYAFQDGGCTPCDCAHTQNNCDPASGECLCPPHTQGLKCEECEEAYWGLDPEQGCQACNCSAVGSTSAQCDVLSGHCPCKKGFGGQSCHQCSLGYRSFPDCVPCGCDLRGTLPDTCDLEQGLCSCSEDGGTCSCKENAVGPQCSKCQAGTFALRGDNPQGCSPCFCFGLSQLCSELEGYVRTLITLASDQPLLHVVSQSNLKGTIEGVHFQPPDTLLDAEAVRQHIYAEPFYWRLPKQFQGDQLLAYGGKLQYSVAFYSTLGTGTSNYEPQVLIKGGRARKHVIYMDAPAPENGVRQDYEVRMKEEFWKYFNSVSEKHVTHSDFMSVLSNIDYILIKASYGQGLQQSRIANISMEVGRKAVELPAEGEAALLLELCVCPPGTAGHSCQDCAPGYYREKLPESGGRGPRPLLAPCVPCNCNNHSDVCDPETGKCLSCRDHTSGDHCELCASGYYGKVTGLPGDCTPCTCPHHPPFSFSPTCVVEGDSDFRCNACLPGYEGQYCERCSAGYHGNPRAAGGSCQTCDCNPQGSVHSDCDRASGQCVCKPGATGLHCEKCLPRHILMESDCVSCDDDCVGPLLNDLDSVGDAVLSLNLTGVSPAPYGILENLENTTKYFQRYLIKENAKKIRAEIQLEGIAEQTENLQKELTRVLARHQKVNAEMERTSNGTQALATFIEQLHANIKEITEKVATLNQTARKDFQPPVSALQSMHQNISSLLGLIKERNFTEMQQNATLELKAAKDLLSRIQKRFQKPQEKLKALKEANSLLSNHSEKLQAAEELLKEAGSKTQESNLLLLLVKANLKEFQEKKLRVQEEQNVTSELIAKGREWVDAAGTHTAAAQDTLTQLEHHRDELLLWARKIRSHVDDLVMQMSKRRARDLVHRAEQHASELQSRAGALDRDLENVRNVSLNATSAAHVHSNIQTLTEEAEMLAADAHKTANKTDLISESLASRGKAVLQRSSRFLKESVSTRRKQQGITMKLDELKNLTSQFQESMDNIMKQANDSLAMLRESPGGMREKGRKARELAAAANESAVKTLEDVLALSLRVFNTSEDLSRVNATVQETNDLLHNSTMTTLLAGRKMKDMEMQANLLLDRLKPLKTLEENLSRNLSEIKLLISRARKQVASIKVAVSADRDCIRAYQPQTSSTNYNTLILNVKTQEPDNLLFYLGSSSSSDFLAVEMRRGKVAFLWDLGSGSTRLEFPEVSINNNRWHSIYITRFGNMGSLSVKEASAAENPPVRTSKSPGPSKVLDINNSTLMFVGGLGGQIKKSPAVKVTHFKGCMGEAFLNGKSIGLWNYIEREGKCNGCFGSSQNEDSSFHFDGSGYAMVEKTLRPTVTQIVILFSTFSPNGLLFYLASNGTKDFLSIELVRGRVKVMVDLGSGPLTLMTDRRYNNGTWYKIAFQRNRKQGLLAVFDAYDTSDKETKQGETPGAASDLNRLEKDLIYVGGLPHSKAVRKGVSSRSYVGCIKNLEISRSTFDLLRNSYGVRKGCALEPIQSVSFLRGGYVEMPPKSLSPESSLLATFATKNSSGILLVALGKDAEEAGGAQAHVPFFSIMLLEGRIEVHVNSGDGTSLRKALLHAPTGSYSDGQEHSISLVRNRRVITIQVDENSPVEMKLGPLTEGKTIDISNLYIGGLPEDKATPMLKMRTSFHGCIKNVVLDAQLLDFTHATGSEQVELDTCLLAEEPMQSLHREHGELPPEPPTLPQPELCAVDTAPGYVAGAHQFGLSQNSHLVLPLNQSDVRKRLQVQLSIRTFASSGLIYYVAHQNQMDYATLQLQEGRLHFMFDLGKGRTKVSHPALLSDGKWHTVKTEYIKRKAFMTVDGQESPSVTVVGNATTLDVERKLYLGGLPSHYRARNIGTITHSIPACIGEIMVNGQQLDKDRPLSASAVDRCYVVAQEGTFFEGSGYAALVKEGYKVRLDLNITLEFRTTSKNGVLLGISSAKVDAIGLEIVDGKVLFHVNNGAGRITATYQPRAARALCDGKWHTLQAHKSKHRIVLTVDGNSVRAESPHTHSTSADTNDPIYVGGYPAHIKQNCLSSRASFRGCVRNLRLSRGSQVQSLDLSRAFDLQGVFPHSCPGPEP", "length": 3083 }, "evidence": [ { "id": "HGNC:6481", "url": "https://alliancegenome.org/gene/HGNC:6481#orthology", "database": "AGR" }, { "id": "MGI:99892", "url": "https://alliancegenome.org/gene/MGI:99892#orthology", "database": "AGR" }, { "id": "RGD:1307207", "url": "https://alliancegenome.org/gene/RGD:1307207#orthology", "database": "AGR" }, { "id": "FB:FBgn0261563", "url": "https://alliancegenome.org/gene/FB:FBgn0261563#orthology", "database": "AGR" }, { "id": "P25391", "url": "https://omabrowser.org/oma/group/P25391/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P24043-1", "protein_name": "Laminin subunit alpha-2", "gene_name": "LAMA2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPGAAGVLLLLLLSGGLGGVQAQRPQQQRQSQAHQQRGLFPAVLNLASNALITTNATCGEKGPEMYCKLVEHVPGQPVRNPQCRICNQNSSNPNQRHPITNAIDGKNTWWQSPSIKNGIEYHYVTITLDLQQVFQIAYVIVKAANSPRPGNWILERSLDDVEYKPWQYHAVTDTECLTLYNIYPRTGPPSYAKDDEVICTSFYSKIHPLENGEIHISLINGRPSADDPSPELLEFTSARYIRLRFQRIRTLNADLMMFAHKDPREIDPIVTRRYYYSVKDISVGGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYPDCKACNCSGLGSKNEDPCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFCSGVSNRCQSSYWTYGKIQDMSGWYLTDLPGRIRVAPQQDDLDSPQQISISNAEARQALPHSYYWSAPAPYLGNKLPAVGGQLTFTISYDLEEEEEDTERVLQLMIILEGNDLSISTAQDEVYLHPSEEHTNVLLLKEESFTIHGTHFPVRRKEFMTVLANLKRVLLQITYSFGMDAIFRLSSVNLESAVSYPTDGSIAAAVEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQSARGCVPCNCNSFGSKSFDCEESGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTACECSHLGNNCDPKTGRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCNCHPKFSGAKCTECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCYCFGTTTQCSEAKGLIRTWVTLKAEQTILPLVDEALQHTTTKGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGGKLKYAIYFEAREETGFSTYNPQVIIRGGTPTHARIIVRHMAAPLIGQLTRHEIEMTEKEWKYYGDDPRVHRTVTREDFLDILYDIHYILIKATYGNFMRQSRISEISMEVAEQGRGTTMTPPADLIEKCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGRKCDGCKHWHAREGWECVFCGDECTGLLLGDLARLEQMVMSINLTGPLPAPYKMLYGLENMTQELKHLLSPQRAPERLIQLAEGNLNTLVTEMNELLTRATKVTADGEQTGQDAERTNTRAKSLGEFIKELARDAEAVNEKAIKLNETLGTRDEAFERNLEGLQKEIDQMIKELRRKNLETQKEIAEDELVAAEALLKKVKKLFGESRGENEEMEKDLREKLADYKNKVDDAWDLLREATDKIREANRLFAVNQKNMTALEKKKEAVESGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDIQTKLPPMSEELNDKIDDLSQEIKDRKLAEKVSQAESHAAQLNDSSAVLDGILDEAKNISFNATAAFKAYSNIKDYIDEAEKVAKEAKDLAHEATKLATGPRGLLKEDAKGCLQKSFRILNEAKKLANDVKENEDHLNGLKTRIENADARNGDLLRTLNDTLGKLSAIPNDTAAKLQAVKDKARQANDTAKDVLAQITELHQNLDGLKKNYNKLADSVAKTNAVVKDPSKNKIIADADATVKNLEQEADRLIDKLKPIKELEDNLKKNISEIKELINQARKQANSIKVSVSSGGDCIRTYKPEIKKGSYNNIVVNVKTAVADNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTIDDSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLFVGGLTGKLKKADAVRVITFTGCMGETYFDNKPIGLWNFREKEGDCKGCTVSPQVEDSEGTIQFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRDLRDFMSVELTDGHIKVSYDLGSGMASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLRNLSMKARPEVNLKKYSGCLKDIEISRTPYNILSSPDYVGVTKGCSLENVYTVSFPKPGFVELSPVPIDVGTEINLSFSTKNESGIILLGSGGTPAPPRRKRRQTGQAYYAILLNRGRLEVHLSTGARTMRKIVIRPEPNLFHDGREHSVHVERTRGIFTVQVDENRRYMQNLTVEQPIEVKKLFVGGAPPEFQPSPLRNIPPFEGCIWNLVINSVPMDFARPVSFKNADIGRCAHQKLREDEDGAAPAEIVIQPEPVPTPAFPTPTPVLTHGPCAAESEPALLIGSKQFGLSRNSHIAIAFDDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLRNGLPYFSYDLGSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRTISPKKADILDVVGMLYVGGLPINYTTRRIGPVTYSIDGCVRNLHMAEAPADLEQPTSSFHVGTCFANAQRGTYFDGTGFAKAVGGFKVGLDLLVEFEFRTTTTTGVLLGISSQKMDGMGIEMIDEKLMFHVDNGAGRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVGGFPDDLKQFGLTTSIPFRGCIRSLKLTKGTGKPLEVNFAKALELRGVQPVSCPAN", "length": 3122 }, "evidence": [ { "id": "FB:FBgn0261563", "url": "https://alliancegenome.org/gene/FB:FBgn0261563#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q60675-1", "protein_name": "Laminin subunit alpha-2", "gene_name": "Lama2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPAATAGILLLLLLGTLEGSQTQRRQSQAHQQRGLFPAVLNLASNALITTNATCGEKGPEMYCKLVEHVPGQPVRNPQCRICNQNSSNPYQRHPITNAIDGKNTWWQSPSIKNGVEYHYVTITLDLQQVFQIAYVIVKAANSPRPGNWILERSLDDVEYKPWQYHAVTDTECLTLYNIYPRTGPPSYAKDDEVICTSFYSKIHPLENGEIHISLINGRPSADDPSPELLEFTSARYIRLRFQRIRTLNADLMMFAHKDPREIDPIVTRRYYYSVKDISVGGMCICYGHARACPLDPATNKSRCECEHNTCGESCDRCCPGFHQKPWRAGTFLTKSECEACNCHGKAEECYYDETVASRNLSLNIHGKYIGGGVCINCTHNTAGINCETCVDGFFRPKGVSPNYPRPCQPCHCDPTGSLSEVCVKDEKYAQRGLKPGSCHCKTGFGGVNCDRCVRGYHGYPDCQPCNCSGLGSTNEDPCVGPCSCKENVEGEDCSRCKSGFFNLQEDNQKGCEECFCSGVSNRCQSSYWTYGNIQDMRGWYLTDLSGRIRMAPQLDNPDSPQQISISNSEARKSLLDGYYWSAPPPYLGNRLPAVGGQLSFTISYDLEEEEDDTEKILQLMIIFEGNDLRISTAYKEVYLEPSEEHIEEVSLKEEAFTIHGTNLPVTRKDFMIVLTNLERVLMQITYNLGMDAIFRLSSVNLESAVPYPTDRRIATDVEVCQCPPGYSGSSCETCWPRHRRVNGTIFGGICEPCQCFAHAEACDDITGECLNCKDHTGGPYCNECLPGFYGDPTRGSPEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDECPIGYTGPRCERCAEGYFGQPSIPGGSCQPCQCNDNLDYSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDAVNAKNCQPCRCNINGSFSEICHTRTGQCECRPNVQGRHCDECKPETFGLQLGRGCLPCNCNSFGSKSFDCEASGQCWCQPGVAGKKCDRCAHGYFNFQEGGCIACDCSHLGNNCDPKTGQCICPPNTTGEKCSECLPNTWGHSIVTGCKVCNCSTVGSLASQCNVNTGQCSCHPKFSGMKCSECSRGHWNYPLCTLCDCFLPGTDATTCDLETRKCSCSDQTGQCSCKVNVEGVHCDRCRPGKFGLDAKNPLGCSSCYCFGVTSQCSEAKGLIRTWVTLSDEQTILPLVDEALQHTTTKGIAFQKPEIVAKMDEVRQELHLEPFYWKLPQQFEGKKLMAYGGKLKYAIYFEARDETGFATYKPQVIIRGGTPTHARIITRHMAAPLIGQLTRHEIEMTEKEWKYYGDDPRISRTVTREDFLDILYDIHYILIKATYGNVVRQSRISEISMEVAEPGHVLAGSPPAHLIERCDCPPGYSGLSCETCAPGFYRLRSEPGGRTPGPTLGTCVPCQCNGHSSQCDPETSVCQNCQHHTAGDFCERCALGYYGIVRGLPNDCQPCACPLISPSNNFSPSCVLEGLEDYRCTACPRGYEGQYCERCAPGYTGSPSSPGGSCQECECDPYGSLPVPCDRVTGLCTCRPGATGRKCDGCEHWHAREGAECVFCGDECTGLLLGDLARLEQMTMNINLTGPLPAPYKILYGLENTTQELKHLLSPQRAPERLIQLAEGNVNTLVMETNELLTRATKVTADGEQTGQDAERTNSRAESLEEFIKGLVQDAEAINEKAVQLNETLGNQDKTAERNLEELQKEIDRMLKELRSKDLQTQKEVAEDELVAAEGLLKRVNKLFGEPRAQNEDMEKDLQQKLAEYKNKLDDAWDLLREATDKTRDANRLSAANQKNMTILETKKEAIEGSKRQIENTLKEGNDILDEANRLLGEINSVIDYVDDIKTKLPPMSEELSDKIDDLAQEIKDRRLAEKVFQAESHAAQLNDSSAVLDGILDEAKNISFNATAAFRAYSNIKDYIDEAEKVAREAKELAQGATKLATSPQGLLKEDAKGSLQKSFRILNEAKKLANDVKGNHNDLNDLKTRLETADLRNSGLLGALNDTMDKLSAITNDTAAKLQAVKEKAREANDTAKAVLAQVKDLHQNLDGLKQNYNKLADSVAKTNAVVKDPSKNKIIADAGTSVRNLEQEADRLIDKLKPIKELEDNLKKNISEIKELINQARKQANSIKVSVSSGGDCVRTYRPEIKKGSYNNIVVHVKTAVADNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTIDDSYWYRIEASRTGRNGSISVRALDGPKASMVPSTYHSVSPPGYTILDVDANAMLFVGGLTGKIKKADAVRVITFTGCMGETYFDNKPIGLWNFREKEGDCKGCTVSPQVEDSEGTIQFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRDLKDFMSVELSDGHVKVSYDLGSGMTSVVSNQNHNDGKWKAFTLSRIQKQANISIVDIDSNQEENVATSSSGNNFGLDLKADDKIYFGGLPTLRNLSMKARPEVNVKKYSGCLKDIEISRTPYNILSSPDYVGVTKGCSLENVYTVSFPKPGFVELAAVSIDVGTEINLSFSTRNESGIILLGSGGTLTPPRRKRRQTTQAYYAIFLNKGRLEVHLSSGTRTMRKIVIKPEPNLFHDGREHSVHVERTRGIFTVQIDEDRRHMQNLTEEQPIEVKKLFVGGAPPEFQPSPLRNIPAFQGCVWNLVINSIPMDFAQPIAFKNADIGRCTYQKPREDESEAVPAEVIVQPQPVPTPAFPFPAPTMVHGPCVAESEPALLTGSKQFGLSRNSHIAIAFDDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLRNGFPYFSYDLGSGDTSTMIPTKINDGQWHKIKIVRVKQEGILYVDDASSQTISPKKADILDVVGILYVGGLPINYTTRRIGPVTYSLDGCVRNLHMEQAPVDLDQPTSSFHVGTCFANAESGTYFDGTGFAKAVGGFKVGLDLLVEFEFRTTRPTGVLLGVSSQKMDGMGIEMIDEKLMFHVDNGAGRFTAIYDAGIPGHMCNGQWHKVTAKKIKNRLELVVDGNQVDAQSPNSASTSADTNDPVFVGGFPGGLNQFGLTTNIRFRGCIRSLKLTKGTGKPLEVNFAKALELRGVQPVSCPTT", "length": 3118 }, "evidence": [ { "id": "FB:FBgn0261563", "url": "https://alliancegenome.org/gene/FB:FBgn0261563#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IP51-1", "protein_name": "Wing blister, isoform B", "gene_name": "wb", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MQIGNFIKWPLGLILILLVTHCQAKRQRKRLRGFSTAKDLQDYSMPLNDNSTELQQNIVSWTGARIASSPDKKKKSPQSSRRHKTKSGLIIESNIADSESMLAIASSESVTKKKPPQRRRNGKLQKSGGGAGGGALRLLKTEDVYSSSFSGGLYPPLFNVVPRAQISVNATCGQNGAEEYCKQVGAKPCGICNAHSSDRAKQRSIQSLISSGSGSGSGSGFEEGWWQSPTLQGGRQFEYVTILLDLKQTFQIFSVWLKSANSPRPASWILEKSLDGINFEPWQYFGLSDADCQRRWNLSGQNGKYVFQNDTEIICSTQFSKPGPLENGVLHASLLKNRPGATDQSPELMKFITTRYIRIRLQGMHSTANQDNSLDWLLDSPSLEKHSFYSLSQLKVSARLDCNGHANRSHESPDDPLMQCICQHNTCGAQCEQCCPLFQDRPYQMGGECEICQCYGHAESCTYDPFLDKGICQSCSNNTAGIECEFCEMGFYRELDAPLTDPCLPCSCNPARSTGGCQSDGGSCNCLEGFQGKNCEECAPGYYGDDCKRCECDERGSLGSTGSCSGVCQCKLNVEGSTCSECAPGYFDLSAENAEGCTSCWCSGVSQTCHSAKLQTLAFETLNDWKITDIQRVKPISIPVDAETNRLIFANELDEVEAIYWQASLGYLGNRLTSYGSRLQLVLSWDVIRGDRSGKPTTGPNVILVGKNGLKIAFGDESLDGLGINLNVTLTEVGWYHVPPTVVDIKTRLRRTEGGDYHGESVTRSQFLSVLVSLDAVLIRAAFHTDQGETSLERAVIYSGGVELGGKSSSQVEQCLCPAGYTGLSCEGCAFGFKRIYENTSDHQILSKCIPCPCNGHSNSCDLQSGNCGDCMHNTFGDRCERCQLGYYGNPLQGTPNDCKRCACPLSEDSNNFSPSCQLKSYNYMDLNPQFELIEHAEYICTQCPEGYTGDHCQVCDDGYFGNPRQPGSSCQRCDCAGGPCNVTTGECITCRGNTEGWHCERCKLGYWGDPAVGCDPCHCHTEGSESGLCDSTDGQCLCKPRYAGQKCDECDVGYANVELRCPSCNCDPLGSLVQDRCDPHTGQCHCKEGVMGAKCHECQDGYFGMNAVAYRMDDLAALRQNSDSDDDEWELVPDTEDPNSESTVACEECHCSSVGSLSSDCDKRTGQCACLANVTGRRCDKCRPGHWNLTAGEGCRDCRCDPHGSRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRCSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPGTWGWQARLGCRECECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFGYPECRRCGCDAEGSFTQADGSIACDSNGQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGCTRCFCFGRSGECEQSDLSWGHIRMAESRNLSVQQIRPHSVPSSDYEYIVVVQMEGSSFHREDAEIQRMNDLSLVPKSTGNVSIGAYGQFYHPLYFQLPPQFYGDRTSSYGGFLYFTLITEGAHKPLERNILGQYPLVQLHAHSKLLLDFYEYEEFEYSLNVTHRVPLHESFWKYHHTSQAVDRNTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMDAAIYIKGSTNLIAKGVERCKCPKRFDGLSCQDPGRSFYRWRNTTIVESVFIEDLIGRAAPCHCNGRSSDCDRETGVCQNCRGNTGGDHCHQCAEGFYGDPNSPHGCQACPCPETNRNFARGCNVWDGEVSCVCKPGYTGRLCERCQAGYFGDPMRYPNTTCQPCNCHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQAERHHLVDNGCKICDNCTLLLLDYMELVGNKLRRGMHNMDLTGIPAPYRKLSEYESAYEKWNGRHWDFSQTKRRLQDYDSADILKLEAHAENLKFQSRKAVATIGKREFAIKSMREDAVTQQHSVGLLRSEILQTLSDLHGYGKSAHYLSLPTALKQARFYLQAIREHDQMVQGIRSTNDCAWKHFYAMGNASDASFDESGRLEMLWRDLNQTNHRVVDMRLQVDRVQEVENEAEDVLEHVRNLSIRVGESHQELDELNQRISDHLDPGYLEQGEGLLRLTVQRQIMLNGHLNQLDGYRILLNTTLGVKTEQQREVRKHWLPKAEKHASHLLARSNEYARKFQPTRNGARIAMLASSAHSNITEAINDARLASILAKERVYEAQRTLYPSDGSSMIERAKHSLHRSKQLQQEALKQMHKSNVLKDKLHRQEQQVEGIKSTIYDSGLRTNNISGQLQGLSDGSARRQAKDSLEMADRTGEQMRAELQKAKDMQKSIQNMRNSFSNLEPDWEIKLGMAQENISLTQTNLRLANVSLSYLEQQAEKEQQVFEVWNNSMAQQLQQLRDQIAKARHAAEAIDVSLESLGPKCIRSYLPASYGLSTSNKIRMSFALSNHLESSPLIHLASSEGRHITLELYKRRVRLVWNLGGTTATVTHPMVVHTRDPKYDDAWYHVEANRTLNLGSLVVRRMNNYGELTPPNPVIITGSTDTEHTRFYQSRSDRISLGGFASKDLQFTPGLNVVVHQVEVDNKPLGLWNFVTSEGSCGGSMVGAKESSASSTARHFNGLGYAQLMKTRPRPTRKNLFSVQMTFRTLDENALLFLAVDDKNNRSVSVTLSRGRIMFRIDYGDESKLEINTTKKYNVGQWIKIEAAREFSAKRSTENGMLRVNNDRPISGAPTLPVNIHLLPDLSKTVYYLGGVPPGFTSGTSKAPGADNPFLGCMKDVQVNGETYDPLESSSYYGVEPSCKNMITKAGFSGNGYLELPSQSLRKRSNTALVFRTLQPDCLLLLAAYPPEILGDYDAKDIKGNFSISLVDGQLHVWVNSGRSFIKMSSNSSQMNDGEFHVVHLIKTGRKLELMVDDELQEIRNLNGNPTVVSLPRDAGGLYIGGAPPHESYTPLAPTFVNLEGAIRDVVFNNRTINFNDALTFANVQIGRNGPLMGSLKGGLYDVLLKTEPMIGKSFTASPEGCKRIGSYSYEPNAFKFGDDIYSYSQLKLPERHFWQRNFHLSFDFRSFYPNGMLYLSPGSKEKPKHYVALVLKDGQLVLVVRGRRREELQLTAKLNDGEWHRVTISCHDRKVTMSVEIGRTDQKTSAQMKLPKKIGASQLLLVGGLPQSPVKVSSDLYVRLEPFKGCLRRVSINNNTQDLARPGKHSNVGQCFPTVERGSYFPGDAYAIYKKNFNVGKYLDLETEFRTSELSGILLSVSDPNGFPALSLELHNGNIIFSCDPGNGAPMRVESSLPTKYALCDNKWHNISALYDGEQIVLRIDQLPAVISVGNQGNAGKVQTRSPLYIGGLPESAPSGSLISRENFKGCIRHVSIRNERRDWIEMEDLRNVLLSECLVSSDES", "length": 3375 }, "evidence": [ { "id": "HGNC:6481", "url": "https://alliancegenome.org/gene/HGNC:6481#orthology", "database": "AGR" }, { "id": "MGI:99892", "url": "https://alliancegenome.org/gene/MGI:99892#orthology", "database": "AGR" }, { "id": "RGD:1307207", "url": "https://alliancegenome.org/gene/RGD:1307207#orthology", "database": "AGR" }, { "id": "FB:FBgn0261563", "url": "https://alliancegenome.org/gene/FB:FBgn0261563#orthology", "database": "AGR" }, { "id": "P25391", "url": "https://omabrowser.org/oma/group/P25391/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "glycosphingolipid binding", "id": "GO:0043208", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043208", "evidence": [ { "database": "UniProtKB", "id": "P25391", "url": "https://www.uniprot.org/uniprotkb/P25391" } ], "pmid": "" }, { "name": "receptor ligand activity", "id": 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"https://www.uniprot.org/uniprotkb/P25391" } ], "pmid": "" }, { "name": "positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "id": "GO:0051897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051897", "evidence": [ { "database": "UniProtKB", "id": "P25391", "url": "https://www.uniprot.org/uniprotkb/P25391" } ], "pmid": "" }, { "name": "positive regulation of muscle cell differentiation", "id": "GO:0051149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051149", "evidence": [ { "database": "UniProtKB", "id": "P25391", "url": "https://www.uniprot.org/uniprotkb/P25391" } ], "pmid": "" }, { "name": "regulation of cell migration", "id": "GO:0030334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030334", "evidence": [ { "database": "UniProtKB", "id": "P25391", "url": "https://www.uniprot.org/uniprotkb/P25391" } ], "pmid": "" }, { "name": "positive regulation of Rac protein signal transduction", "id": "GO:0035022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035022", "evidence": [ { "database": "UniProtKB", "id": "P25391", "url": "https://www.uniprot.org/uniprotkb/P25391" } ], "pmid": "" }, { "name": "positive regulation of integrin-mediated signaling pathway", "id": "GO:2001046", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001046", "evidence": [ { "database": "UniProtKB", "id": "P25391", "url": "https://www.uniprot.org/uniprotkb/P25391" } ], "pmid": "" }, { "name": "regulation of embryonic development", "id": "GO:0045995", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045995", "evidence": [ { "database": "UniProtKB", "id": "P25391", "url": "https://www.uniprot.org/uniprotkb/P25391" } ], "pmid": "" }, { "name": "negative regulation of muscle cell apoptotic process", "id": "GO:0010656", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010656", "evidence": [ { "database": "UniProtKB", "id": "P25391", "url": "https://www.uniprot.org/uniprotkb/P25391" } ], "pmid": "" }, { "name": "regulation of basement membrane organization", "id": "GO:0110011", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0110011", "evidence": [ { "database": "UniProtKB", "id": "P25391", "url": "https://www.uniprot.org/uniprotkb/P25391" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 10, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "P25391", "url": "https://www.uniprot.org/uniprotkb/P25391" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "P25391", "url": "https://www.uniprot.org/uniprotkb/P25391" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "P25391", "url": "https://www.uniprot.org/uniprotkb/P25391" } ], "pmid": "" }, { "name": "cell-cell junction", "id": "GO:0005911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005911", "evidence": [ { "database": "UniProtKB", "id": "P25391", "url": "https://www.uniprot.org/uniprotkb/P25391" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "P25391", "url": "https://www.uniprot.org/uniprotkb/P25391" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "P25391", "url": "https://www.uniprot.org/uniprotkb/P25391" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "P25391", "url": "https://www.uniprot.org/uniprotkb/P25391" } ], "pmid": "" }, { "name": "basement membrane", "id": "GO:0005604", "url": 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