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"description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. 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It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": 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"MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", 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"" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. 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"https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": 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"https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": 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"https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] }, { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] }, { "disease_id": "DOID:1793", "recommended_name": { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas." }, "synonyms": [ { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "Ca body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "Ca head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1793", "name": "Ca tail of pancreas", "description": "" }, { "id": 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[], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", 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"MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": 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"https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] }, { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": 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"malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3149", "DOID:3451" ], "evidence": [ { "id": "4159", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4159" } ] }, { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, 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"id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ], "unlinked_id_list": [ "DOID:4765" ], "evidence": [ { "id": "1324", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1324" } ] }, { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": 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"evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions.", "journal": "Scientific reports", "date": "2025-07-02", "authors": "Li Guofang, Meng Fanxu, Zhong Xiaomin, Yu Kairan, Zhang Nana, Zhang Keren, Huang Huang, Li Wenli, Zhang Jianing, Wang Wei, Ren Yan, Liu Yubo", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics.", "journal": "Journal of proteome research", "date": "2024-10-04", "authors": "Hou Chunyan, Wu Ci, Wu Zichun, Cheng Yifan, Li Weiyu, Sun Hui, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247" } ] }, { "title": "`Two Birds One Stone` Strategy for the Site-Specific Analysis of Core Fucosylation and O-GlcNAcylation.", "journal": "Journal of the American Chemical Society", "date": "2023-07-26", "authors": "Luo Yawen, Wang Yuqiu, Tian Yinping, Zhou Hu, Wen Liuqing", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "37340703", "url": "https://glygen.org/publication/PubMed/37340703" } ] }, { "title": "Comparative analysis of Cu (I)-catalyzed alkyne-azide cycloaddition (CuAAC) and strain-promoted alkyne-azide cycloaddition (SPAAC) in O-GlcNAc proteomics.", "journal": "Electrophoresis", "date": "2016", "authors": "Li S, Zhu H, Wang J, Wang X, Li X, Ma C, Wen L, Yu B, Wang Y, Li J, Wang PG", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": 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"title": "Aspartate Residues Far from the Active Site Drive O-GlcNAc Transferase Substrate Selection.", "journal": "Journal of the American Chemical Society", "date": "2019", "authors": "Joiner CM, Levine ZG, Aonbangkhen C, Woo CM, Walker S", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "31373491", "url": "https://glygen.org/publication/PubMed/31373491" } ] }, { "title": "Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation.", "journal": "National science review", "date": "2024-11", "authors": "Xiong Yingying, Lu Zhuoer, Shao Yuyin, Meng Peiyi, Wang Guoli, Zhou Xinwen, Yao Jun, Bao Huimin, Lu Haojie", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" 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Chen S, Zhu J, Wang J, Huang N, Yin M, Sun F, Xu M, Pan Q", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "31637018", "url": "https://glygen.org/publication/PubMed/31637018" } ] }, { "title": "A Chemoenzymatic Method Based on Easily Accessible Enzymes for Profiling Protein O-GlcNAcylation.", "journal": "Analytical chemistry", "date": "2020", "authors": "Xu S, Sun F, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "DNA probe pulldown screening 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protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "GATAD2B O-GlcNAcylation Regulates Breast Cancer Stem-like Potential and Drug Resistance.", "journal": "Cells", "date": "2025-03-08", "authors": "Le Minh Giang, Merzy Jessica, Esquea Emily M, Ahmed Nusaiba N, Young Riley G, Sharp Ryan J, Dhameliya Tejsi T, Agana Bernice, Lee Mi-Hye, Bethard Jennifer R, Comte-Walters Susana, Ball Lauren E, Reginato Mauricio J", "evidence": [ { "database": "O-GlcNAc 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General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "O-GlcNAcylation determines the solubility, filament organization, and stability of keratins 8 and 18.", "journal": "The Journal of biological chemistry", "date": "2010", "authors": "Srikanth B, Vaidya MM, Kalraiya RD", "evidence": [ { "database": "UniProtKB", "id": "P05783", "url": "https://www.uniprot.org/uniprotkb/P05783#ptm_processing" }, { "database": "UniProtKB", "id": "P05783", "url": "https://www.uniprot.org/uniprotkb/P05783" }, { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "20729549", "url": "https://glygen.org/publication/PubMed/20729549" } ] }, { "title": "Ultradeep O-GlcNAc proteomics reveals widespread O-GlcNAcylation on tyrosine residues of proteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2024-11-19", "authors": "Hou Chunyan, Deng Jingtao, Wu Ci, Zhang Jing, Byers Stephen, Moremen Kelley W, Pei Huadong, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497" } ] }, { "title": "Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.", "journal": "Nature communications", "date": "2019", "authors": "Hao Y, Fan X, Shi Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "O-GlcNAcylation promotes fatty acid synthase activity under nutritional stress as a pro-survival mechanism in cancer cells.", "journal": "Proteomics", "date": "2022", "authors": "Wong YK, Wang J, Lim TK, Lin Q, Yap CT, Shen HM", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "35083852", "url": "https://glygen.org/publication/PubMed/35083852" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2022", "authors": "Chen Y, Tang F, Qin H, Yue X, Nie Y, Huang W, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "title": "Functional Implications of O-GlcNAcylation-dependent Phosphorylation at a Proximal Site on Keratin 18.", "journal": "The Journal of biological chemistry", "date": "2016", "authors": "Kakade PS, Budnar S, Kalraiya RD, Vaidya MM", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "GlyGen", "id": "GLY_000481", "url": "https://data.glygen.org/GLY_000481" }, { 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Ohtake F, Kitagawa H, Roeder RG, Brown M, Kato S", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "22121020", "url": "https://glygen.org/publication/PubMed/22121020" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "O-GlcNAc transferase regulates collagen 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Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "An Isotope-Coded Photocleavable Probe for Quantitative Profiling of Protein O-GlcNAcylation.", "journal": "ACS chemical biology", "date": "2019", "authors": "Li J, Li Z, Duan X, Qin K, Dang L, Sun S, Cai L, Hsieh-Wilson LC, Wu L, Yi W", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": 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C., Vester-Christensen M. B., Ferreira J. A., Afonso L. P., Santos L. L., Pinto de Sousa J., Mandel U., Clausen H., Vakhrushev S. Y., Reis C. 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General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "O-GlcNAcylation determines the solubility, filament organization, and stability of keratins 8 and 18.", "journal": "The Journal of biological chemistry", "date": "2010", "authors": "Srikanth B, Vaidya MM, Kalraiya RD", "evidence": [ { "database": "UniProtKB", "id": "P05783", "url": "https://www.uniprot.org/uniprotkb/P05783#ptm_processing" }, { "database": "UniProtKB", "id": "P05783", "url": "https://www.uniprot.org/uniprotkb/P05783" }, { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": 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Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "O-GlcNAcylation promotes fatty acid synthase activity under nutritional stress as a pro-survival mechanism in cancer cells.", "journal": "Proteomics", "date": "2022", "authors": "Wong YK, Wang J, Lim TK, Lin Q, Yap CT, Shen HM", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "35083852", "url": "https://glygen.org/publication/PubMed/35083852" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for 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Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "An Isotope-Coded Photocleavable Probe for Quantitative Profiling of Protein O-GlcNAcylation.", "journal": "ACS chemical biology", "date": "2019", "authors": "Li J, Li Z, Duan X, Qin K, Dang L, Sun S, Cai L, Hsieh-Wilson LC, Wu L, Yi W", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "30620550", "url": "https://glygen.org/publication/PubMed/30620550" } ] }, { "title": "Aspartate Residues Far from the Active Site Drive O-GlcNAc Transferase Substrate Selection.", "journal": "Journal of the American Chemical Society", "date": "2019", "authors": "Joiner CM, Levine ZG, Aonbangkhen C, Woo CM, Walker S", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "31373491", "url": "https://glygen.org/publication/PubMed/31373491" } ] }, { "title": "Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation.", "journal": "National science review", "date": "2024-11", "authors": "Xiong Yingying, Lu Zhuoer, Shao Yuyin, Meng Peiyi, Wang Guoli, Zhou Xinwen, Yao Jun, Bao Huimin, Lu Haojie", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" 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Chen S, Zhu J, Wang J, Huang N, Yin M, Sun F, Xu M, Pan Q", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "31637018", "url": "https://glygen.org/publication/PubMed/31637018" } ] }, { "title": "A Chemoenzymatic Method Based on Easily Accessible Enzymes for Profiling Protein O-GlcNAcylation.", "journal": "Analytical chemistry", "date": "2020", "authors": "Xu S, Sun F, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions.", "journal": "Scientific reports", "date": "2025-07-02", "authors": "Li Guofang, Meng Fanxu, Zhong Xiaomin, Yu Kairan, Zhang Nana, Zhang Keren, Huang Huang, Li Wenli, Zhang Jianing, Wang Wei, Ren Yan, Liu Yubo", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": 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General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "O-GlcNAcylation determines the solubility, filament organization, and stability of keratins 8 and 18.", "journal": "The Journal of biological chemistry", "date": "2010", "authors": "Srikanth B, Vaidya MM, Kalraiya RD", "evidence": [ { "database": "UniProtKB", "id": "P05783", "url": "https://www.uniprot.org/uniprotkb/P05783#ptm_processing" }, { "database": "UniProtKB", "id": "P05783", "url": "https://www.uniprot.org/uniprotkb/P05783" }, { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "20729549", "url": "https://glygen.org/publication/PubMed/20729549" } ] }, { "title": "Ultradeep O-GlcNAc proteomics reveals widespread O-GlcNAcylation on tyrosine residues of proteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2024-11-19", "authors": "Hou Chunyan, Deng Jingtao, Wu Ci, Zhang Jing, Byers Stephen, Moremen Kelley W, Pei Huadong, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "39531497", "url": "https://glygen.org/publication/PubMed/39531497" } ] }, { "title": "Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.", "journal": "Nature communications", "date": "2019", "authors": "Hao Y, Fan X, Shi Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "O-GlcNAcylation promotes fatty acid synthase activity under nutritional stress as a pro-survival mechanism in cancer cells.", "journal": "Proteomics", "date": "2022", "authors": "Wong YK, Wang J, Lim TK, Lin Q, Yap CT, Shen HM", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "35083852", "url": "https://glygen.org/publication/PubMed/35083852" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2022", "authors": "Chen Y, Tang F, Qin H, Yue X, Nie Y, Huang W, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "title": "Functional Implications of O-GlcNAcylation-dependent Phosphorylation at a Proximal Site on Keratin 18.", "journal": "The Journal of biological chemistry", "date": "2016", "authors": "Kakade PS, Budnar S, Kalraiya RD, Vaidya MM", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "GlyGen", "id": "GLY_000481", "url": "https://data.glygen.org/GLY_000481" }, { 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biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics.", "journal": "Journal of proteome research", "date": "2024-10-04", "authors": "Hou Chunyan, Wu Ci, Wu Zichun, Cheng Yifan, Li Weiyu, Sun Hui, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247" } ] }, { "title": "`Two Birds One Stone` Strategy 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therapy", "date": "2019", "authors": "Song H, Ma J, Bian Z, Chen S, Zhu J, Wang J, Huang N, Yin M, Sun F, Xu M, Pan Q", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "31637018", "url": "https://glygen.org/publication/PubMed/31637018" } ] }, { "title": "A Chemoenzymatic Method Based on Easily Accessible Enzymes for Profiling Protein O-GlcNAcylation.", "journal": "Analytical chemistry", "date": "2020", "authors": "Xu S, Sun F, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": 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Yuqiu, Tian Yinping, Zhou Hu, Wen Liuqing", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "37340703", "url": "https://glygen.org/publication/PubMed/37340703" } ] }, { "title": "Comparative analysis of Cu (I)-catalyzed alkyne-azide cycloaddition (CuAAC) and strain-promoted alkyne-azide cycloaddition (SPAAC) in O-GlcNAc proteomics.", "journal": "Electrophoresis", "date": "2016", "authors": "Li S, Zhu H, Wang J, Wang X, Li X, Ma C, Wen L, Yu B, Wang Y, Li J, Wang PG", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "26853435", "url": "https://glygen.org/publication/PubMed/26853435" } ] }, { "title": "Characterization of O-GlcNAc cycling and proteomic identification of differentially O-GlcNAcylated proteins during G1/S transition.", 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Bethard Jennifer R, Comte-Walters Susana, Ball Lauren E, Reginato Mauricio J", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "40136647", "url": "https://glygen.org/publication/PubMed/40136647" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell 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General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "O-GlcNAcylation determines the solubility, filament organization, and stability of keratins 8 and 18.", "journal": "The Journal of biological chemistry", "date": "2010", "authors": "Srikanth B, Vaidya MM, Kalraiya RD", "evidence": [ { "database": "UniProtKB", "id": "P05783", "url": "https://www.uniprot.org/uniprotkb/P05783#ptm_processing" }, { "database": "UniProtKB", "id": "P05783", "url": "https://www.uniprot.org/uniprotkb/P05783" }, { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": 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Biofunctional Reagent for Efficient Enrichment and Large-Scale Identification of O-GlcNAc Proteins by Mass Spectrometry.", "journal": "Analytical chemistry", "date": "2017", "authors": "Zhang W, Liu T, Dong H, Bai H, Tian F, Shi Z, Chen M, Wang J, Qin W, Qian X", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "28510447", "url": "https://glygen.org/publication/PubMed/28510447" } ] }, { "title": "O-GlcNAcylation Quantification of Certain Protein by the Proximity Ligation Assay and Clostridium perfringen OGA(D298N)(CpOGA(D298N)).", "journal": "ACS chemical biology", "date": "2021", "authors": "Song J, Liu C, Wang X, Xu B, Liu X, Li Y, Xia J, Li Y, Zhang C, Li D, Sun H", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "34105348", "url": "https://glygen.org/publication/PubMed/34105348" } ] }, { "title": "Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "An Isotope-Coded Photocleavable Probe for Quantitative Profiling of Protein O-GlcNAcylation.", "journal": "ACS chemical biology", "date": "2019", "authors": "Li J, Li Z, Duan X, Qin K, Dang L, Sun S, Cai L, Hsieh-Wilson LC, Wu L, Yi W", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "30620550", "url": "https://glygen.org/publication/PubMed/30620550" } ] }, { "title": "Aspartate Residues Far from the Active Site Drive O-GlcNAc Transferase Substrate Selection.", "journal": "Journal of the American Chemical Society", "date": "2019", "authors": "Joiner CM, Levine ZG, Aonbangkhen C, Woo CM, Walker S", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "31373491", "url": "https://glygen.org/publication/PubMed/31373491" } ] }, { "title": "Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation.", "journal": "National science review", "date": "2024-11", "authors": "Xiong Yingying, Lu Zhuoer, Shao Yuyin, Meng Peiyi, Wang Guoli, Zhou Xinwen, Yao Jun, Bao Huimin, Lu Haojie", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244" } ] }, { "title": "Proteomic analysis and abrogated expression of O-GlcNAcylated proteins associated with primary breast cancer.", "journal": "Proteomics", "date": "2013", "authors": "Champattanachai V, Netsirisawan P, Chaiyawat P, Phueaouan T, Charoenwattanasatien R, Chokchaichamnankit D, Punyarit P, Srisomsap C, Svasti J", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "23576270", "url": "https://glygen.org/publication/PubMed/23576270" } ] }, { "title": "Global profiling of O-GlcNAcylated and/or phosphorylated proteins in hepatoblastoma.", "journal": "Signal transduction and targeted therapy", "date": "2019", "authors": "Song H, Ma J, Bian Z, Chen S, Zhu J, Wang J, Huang N, Yin M, Sun F, Xu M, Pan Q", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "31637018", "url": "https://glygen.org/publication/PubMed/31637018" } ] }, { "title": "A Chemoenzymatic Method Based on Easily Accessible Enzymes for Profiling Protein O-GlcNAcylation.", "journal": "Analytical chemistry", "date": "2020", "authors": "Xu S, Sun F, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions.", "journal": "Scientific reports", "date": "2025-07-02", "authors": "Li Guofang, Meng Fanxu, Zhong Xiaomin, Yu Kairan, Zhang Nana, Zhang Keren, Huang Huang, Li Wenli, Zhang Jianing, Wang Wei, Ren Yan, Liu Yubo", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "40596516", "url": "https://glygen.org/publication/PubMed/40596516" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics.", "journal": "Journal of proteome research", "date": "2024-10-04", "authors": "Hou Chunyan, Wu Ci, Wu Zichun, Cheng Yifan, Li Weiyu, Sun Hui, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247" } ] }, { "title": "`Two Birds One Stone` Strategy for the Site-Specific Analysis of Core Fucosylation and O-GlcNAcylation.", "journal": "Journal of the American Chemical Society", "date": "2023-07-26", "authors": "Luo Yawen, Wang Yuqiu, Tian Yinping, Zhou Hu, Wen Liuqing", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "37340703", "url": "https://glygen.org/publication/PubMed/37340703" } ] }, { "title": "Comparative analysis of Cu (I)-catalyzed alkyne-azide cycloaddition (CuAAC) and strain-promoted alkyne-azide cycloaddition (SPAAC) in O-GlcNAc proteomics.", "journal": "Electrophoresis", "date": "2016", "authors": "Li S, Zhu H, Wang J, Wang X, Li X, Ma C, Wen L, Yu B, Wang Y, Li J, Wang PG", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": 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biological chemistry", "date": "1997", "authors": "Haltiwanger RS, Philipsberg GA", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "9079710", "url": "https://glygen.org/publication/PubMed/9079710" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": 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General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "O-GlcNAcylation determines the solubility, filament organization, and stability of keratins 8 and 18.", "journal": "The Journal of biological chemistry", "date": "2010", "authors": "Srikanth B, Vaidya MM, Kalraiya RD", "evidence": [ { "database": "UniProtKB", "id": "P05783", "url": "https://www.uniprot.org/uniprotkb/P05783#ptm_processing" }, { "database": "UniProtKB", "id": "P05783", "url": "https://www.uniprot.org/uniprotkb/P05783" }, { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": 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Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "O-GlcNAcylation promotes fatty acid synthase activity under nutritional stress as a pro-survival mechanism in cancer cells.", "journal": "Proteomics", "date": "2022", "authors": "Wong YK, Wang J, Lim TK, Lin Q, Yap CT, Shen HM", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "35083852", "url": "https://glygen.org/publication/PubMed/35083852" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2022", "authors": "Chen Y, Tang F, Qin H, Yue X, Nie Y, Huang W, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "title": "Functional Implications of O-GlcNAcylation-dependent Phosphorylation at a Proximal Site on Keratin 18.", "journal": "The Journal of biological chemistry", "date": "2016", "authors": "Kakade PS, Budnar S, Kalraiya RD, Vaidya MM", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "GlyGen", "id": "GLY_000481", "url": "https://data.glygen.org/GLY_000481" }, { 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O-GlcNAc Proteins by Mass Spectrometry.", "journal": "Analytical chemistry", "date": "2017", "authors": "Zhang W, Liu T, Dong H, Bai H, Tian F, Shi Z, Chen M, Wang J, Qin W, Qian X", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "28510447", "url": "https://glygen.org/publication/PubMed/28510447" } ] }, { "title": "O-GlcNAcylation Quantification of Certain Protein by the Proximity Ligation Assay and Clostridium perfringen OGA(D298N)(CpOGA(D298N)).", "journal": "ACS chemical biology", "date": "2021", "authors": "Song J, Liu C, Wang X, Xu B, Liu X, Li Y, Xia J, Li Y, Zhang C, Li D, Sun H", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", 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Wang PG", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "26853435", "url": "https://glygen.org/publication/PubMed/26853435" } ] }, { "title": "Characterization of O-GlcNAc cycling and proteomic identification of differentially O-GlcNAcylated proteins during G1/S transition.", "journal": "Biochimica et biophysica acta", "date": "2012", "authors": "Drougat L, Olivier-Van Stichelen S, Mortuaire M, Foulquier F, Lacoste AS, Michalski JC, Lefebvre T, Vercoutter-Edouart AS", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "22967762", "url": "https://glygen.org/publication/PubMed/22967762" } ] }, { "title": "Mitotic arrest with nocodazole induces selective changes in the level of O-linked N-acetylglucosamine and accumulation of 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"reference": [ { "type": "PubMed", "id": "31373491", "url": "https://glygen.org/publication/PubMed/31373491" } ] }, { "title": "Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation.", "journal": "National science review", "date": "2024-11", "authors": "Xiong Yingying, Lu Zhuoer, Shao Yuyin, Meng Peiyi, Wang Guoli, Zhou Xinwen, Yao Jun, Bao Huimin, Lu Haojie", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "39534244", "url": "https://glygen.org/publication/PubMed/39534244" } ] }, { "title": "Proteomic analysis and abrogated expression of O-GlcNAcylated proteins associated with primary breast cancer.", "journal": "Proteomics", "date": "2013", "authors": "Champattanachai V, Netsirisawan P, Chaiyawat P, Phueaouan T, 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Easily Accessible Enzymes for Profiling Protein O-GlcNAcylation.", "journal": "Analytical chemistry", "date": "2020", "authors": "Xu S, Sun F, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "DNA probe pulldown screening uncovers O-GlcNAcylation modulation of transcription factor DNA interactions.", "journal": "Scientific reports", "date": "2025-07-02", "authors": "Li Guofang, Meng Fanxu, Zhong Xiaomin, Yu Kairan, Zhang Nana, Zhang Keren, Huang Huang, Li Wenli, Zhang Jianing, Wang Wei, Ren Yan, Liu Yubo", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": 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incompletely processed N-glycans on proteins from HT29 cells.", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Haltiwanger RS, Philipsberg GA", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "9079710", "url": "https://glygen.org/publication/PubMed/9079710" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } 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General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "O-GlcNAcylation determines the solubility, filament organization, and stability of keratins 8 and 18.", "journal": "The Journal of biological chemistry", "date": "2010", "authors": "Srikanth B, Vaidya MM, Kalraiya RD", "evidence": [ { "database": "UniProtKB", "id": "P05783", "url": "https://www.uniprot.org/uniprotkb/P05783#ptm_processing" }, { "database": "UniProtKB", "id": "P05783", "url": "https://www.uniprot.org/uniprotkb/P05783" }, { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": 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Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "O-GlcNAcylation promotes fatty acid synthase activity under nutritional stress as a pro-survival mechanism in cancer cells.", "journal": "Proteomics", "date": "2022", "authors": "Wong YK, Wang J, Lim TK, Lin Q, Yap CT, Shen HM", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "35083852", "url": "https://glygen.org/publication/PubMed/35083852" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2022", "authors": "Chen Y, Tang F, Qin H, Yue X, Nie Y, Huang W, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "title": "Functional Implications of O-GlcNAcylation-dependent Phosphorylation at a Proximal Site on Keratin 18.", "journal": "The Journal of biological chemistry", "date": "2016", "authors": "Kakade PS, Budnar S, Kalraiya RD, Vaidya MM", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "GlyGen", "id": "GLY_000481", "url": "https://data.glygen.org/GLY_000481" }, { 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Ohtake F, Kitagawa H, Roeder RG, Brown M, Kato S", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "22121020", "url": "https://glygen.org/publication/PubMed/22121020" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "O-GlcNAc transferase regulates collagen 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"https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics.", "journal": "Journal of proteome research", "date": "2024-10-04", "authors": "Hou Chunyan, Wu Ci, Wu Zichun, Cheng Yifan, Li Weiyu, Sun Hui, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "39302247", "url": "https://glygen.org/publication/PubMed/39302247" } ] }, { "title": "`Two Birds One Stone` Strategy for the Site-Specific Analysis of Core Fucosylation and O-GlcNAcylation.", "journal": "Journal of the American Chemical Society", "date": "2023-07-26", "authors": "Luo Yawen, Wang Yuqiu, Tian Yinping, Zhou Hu, Wen Liuqing", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": 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General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "O-GlcNAcylation determines the solubility, filament organization, and stability of keratins 8 and 18.", "journal": "The Journal of biological chemistry", "date": "2010", "authors": "Srikanth B, Vaidya MM, Kalraiya RD", "evidence": [ { "database": "UniProtKB", "id": "P05783", "url": "https://www.uniprot.org/uniprotkb/P05783#ptm_processing" }, { "database": "UniProtKB", "id": "P05783", "url": "https://www.uniprot.org/uniprotkb/P05783" }, { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": 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Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" }, { "database": "O-GlcNAc Atlas", "id": "P05783", "url": "https://oglcnac.org/atlas/detail/P05783" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "O-GlcNAcylation promotes fatty acid synthase activity under nutritional stress as a pro-survival mechanism in cancer cells.", "journal": "Proteomics", "date": "2022", "authors": "Wong YK, Wang J, Lim TK, Lin Q, Yap CT, Shen HM", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05783", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05783" } ], "reference": [ { "type": "PubMed", "id": "35083852", "url": "https://glygen.org/publication/PubMed/35083852" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for 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kinase kinase 4 (MKK4) and MKK7.", "journal": "The Biochemical journal", "date": "2000", "authors": "Fleming Y, Armstrong CG, Morrice N, Paterson A, Goedert M, Cohen P", "evidence": [ { "database": "UniProtKB", "id": "P45983", "url": "https://www.uniprot.org/uniprotkb/P45983" }, { "database": "iPTMnet", "id": "P45983-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P45983-1" } ], "reference": [ { "type": "PubMed", "id": "11062067", "url": "https://glygen.org/publication/PubMed/11062067" } ] }, { "title": "MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines.", "journal": "Genes & development", "date": "2001", "authors": "Tournier C, Dong C, Turner TK, Jones SN, Flavell RA, Davis RJ", "evidence": [ { "database": "iPTMnet", "id": "P45983", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P45983" } ], "reference": [ { "type": "PubMed", "id": "11390361", "url": 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{ "title": "A quantitative atlas of mitotic phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP", "evidence": [ { "database": "iPTMnet", "id": "P45983-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P45983-1" } ], "reference": [ { "type": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ] }, { "title": "MEKK1/JNK signaling stabilizes and activates p53.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1998", "authors": "Fuchs SY, Adler V, Pincus MR, Ronai Z", "evidence": [ { "database": "iPTMnet", "id": "P45983", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P45983" } ], "reference": [ { "type": "PubMed", "id": "9724739", "url": "https://glygen.org/publication/PubMed/9724739" } ] }, { "title": "The JNKK2-JNK1 fusion protein acts as a constitutively active c-Jun kinase that stimulates c-Jun transcription activity.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Zheng C, Xiang J, Hunter T, Lin A", "evidence": [ { "database": "iPTMnet", "id": "P45983", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P45983" } ], "reference": [ { "type": "PubMed", "id": "10506143", "url": "https://glygen.org/publication/PubMed/10506143" } ] }, { "title": "Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Zhang H, Shi X, Zhang QJ, Hampong M, Paddon H, Wahyuningsih D, Pelech S", "evidence": [ { "database": "iPTMnet", "id": "P45983", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P45983" } ], "reference": [ { "type": "PubMed", "id": "12221076", "url": 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"id": "15138488", "url": "https://glygen.org/publication/PubMed/15138488" } ] }, { "title": "UV-induced apoptosis in SH-SY5Y cells: contribution to apoptosis by JNK signaling and cytochrome c.", "journal": "Journal of neuroscience research", "date": "2004", "authors": "Berglund CM, Radesater AC, Persson MA, Budd Haeberlein SL", "evidence": [ { "database": "iPTMnet", "id": "P45983", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P45983" } ], "reference": [ { "type": "PubMed", "id": "15389828", "url": "https://glygen.org/publication/PubMed/15389828" } ] }, { "title": "NMDA and dopamine converge on the NMDA-receptor to induce ERK activation and synaptic depression in mature hippocampus.", "journal": "PloS one", "date": "2006", "authors": "Kaphzan H, O'Riordan KJ, Mangan KP, Levenson JM, Rosenblum K", "evidence": [ { "database": "iPTMnet", "id": "P45983", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P45983" } ], "reference": [ { "type": "PubMed", "id": 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"reference": [ { "type": "PubMed", "id": "18286207", "url": "https://glygen.org/publication/PubMed/18286207" } ] }, { "title": "Hydrogen peroxide promotes Abeta production through JNK-dependent activation of gamma-secretase.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Shen C, Chen Y, Liu H, Zhang K, Zhang T, Lin A, Jing N", "evidence": [ { "database": "iPTMnet", "id": "P45983", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P45983" } ], "reference": [ { "type": "PubMed", "id": "18436531", "url": "https://glygen.org/publication/PubMed/18436531" } ] }, { "title": "Altered PI3-kinase/Akt signalling in skeletal muscle of young men with low birth weight.", "journal": "PloS one", "date": "2008", "authors": "Jensen CB, Martin-Gronert MS, Storgaard H, Madsbad S, Vaag A, Ozanne SE", "evidence": [ { "database": "iPTMnet", "id": "P45983", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P45983" } ], "reference": [ { "type": "PubMed", 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"authors": "Zielinski R, Przytycki PF, Zheng J, Zhang D, Przytycka TM, Capala J", "evidence": [ { "database": "iPTMnet", "id": "P45983", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P45983" } ], "reference": [ { "type": "PubMed", "id": "19732446", "url": "https://glygen.org/publication/PubMed/19732446" } ] }, { "title": "Basal cancer cell survival involves JNK2 suppression of a novel JNK1/c-Jun/Bcl-3 apoptotic network.", "journal": "PloS one", "date": "2009", "authors": "Ahmed SU, Milner J", "evidence": [ { "database": "iPTMnet", "id": "P45983", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P45983" } ], "reference": [ { "type": "PubMed", "id": "19806201", "url": "https://glygen.org/publication/PubMed/19806201" } ] }, { "title": "An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation.", "journal": "PLoS biology", "date": "2009", "authors": "Rosse C, Formstecher E, Boeckeler K, Zhao Y, Kremerskothen J, White MD, Camonis JH, Parker PJ", "evidence": [ { "database": "iPTMnet", "id": "P45983", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P45983" } ], "reference": [ { "type": "PubMed", "id": "19885391", "url": "https://glygen.org/publication/PubMed/19885391" } ] }, { "title": "Interplay between Cdh1 and JNK activity during the cell cycle.", "journal": "Nature cell biology", "date": "2010", "authors": "Gutierrez GJ, Tsuji T, Chen M, Jiang W, Ronai ZA", "evidence": [ { "database": "iPTMnet", "id": "P45983", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P45983" } ], "reference": [ { "type": "PubMed", "id": "20581839", "url": "https://glygen.org/publication/PubMed/20581839" } ] }, { "title": "2-Phenyl-5-(pyrrolidin-1-yl)-1-(3,4,5-trimethoxybenzyl)-1H-benzimidazole, a benzimidazole derivative, inhibits growth of human prostate cancer cells by affecting tubulin and c-Jun N-terminal kinase.", "journal": "British journal of pharmacology", "date": "2010", "authors": "Chang WL, Chang CS, Chiang PC, Ho YF, Liu JF, Chang KW, Guh JH", "evidence": [ { "database": "iPTMnet", "id": "P45983", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P45983" } ], "reference": [ { "type": "PubMed", "id": "20649571", "url": "https://glygen.org/publication/PubMed/20649571" } ] }, { "title": "Chronic treatment with epoxyeicosatrienoic acids modulates insulin signaling and prevents insulin resistance in hepatocytes.", "journal": "Prostaglandins & other lipid mediators", "date": "2011", "authors": "Skepner JE, Shelly LD, Ji C, Reidich B, Luo Y", "evidence": [ { "database": "iPTMnet", "id": "P45983", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P45983" } ], "reference": [ { "type": "PubMed", "id": "21040800", "url": "https://glygen.org/publication/PubMed/21040800" } ] }, { "title": "Defective anchoring of JNK1 in the cytoplasm by MKK7 in Jurkat cells is associated with resistance to Fas-mediated apoptosis.", "journal": "Mol. 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"https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. 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}, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. 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"cancer of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian tumour", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovary neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumour of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumour of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, somatic", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian malignant tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian malignant tumour", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary cancer", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "OVCAS1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MIM:167000", "resource": "MIM", "url": "https://www.omim.org/entry/167000", "name": "Ovarian cancer", "description": "Ovarian cancer" } ], "unlinked_id_list": [ "DOID:2151" ], "evidence": [ { "id": "2394", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2394" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that 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Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" 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"url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": 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Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). 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"DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] }, { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant 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"description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] }, { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": 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}, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, 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"https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": 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"resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", 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"familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, 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I. 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Exp. Med.", "date": "2002", "authors": "Yoshida T, Hanada T, Tokuhisa T, Kosai K, Sata M, Kohara M, Yoshimura A", "evidence": [ { "database": "UniProtKB", "id": "P40763", "url": "https://www.uniprot.org/uniprotkb/P40763" }, { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "12208879", "url": "https://glygen.org/publication/PubMed/12208879" } ] }, { "title": "Expression of STAT3 and its phosphorylated forms in mantle cell lymphoma cell lines and tumours.", "journal": "The Journal of pathology", "date": "2003", "authors": "Lai R, Rassidakis GZ, Medeiros LJ, Leventaki V, Keating M, McDonnell TJ", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "12474230", "url": "https://glygen.org/publication/PubMed/12474230" } ] }, { "title": "Angiotensin II effects on STAT3 phosphorylation in cardiomyocytes: evidence for Erk-dependent Tyr705 dephosphorylation.", "journal": "Basic research in cardiology", "date": "2003", "authors": "Booz GW, Day JN, Baker KM", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "12494267", "url": "https://glygen.org/publication/PubMed/12494267" } ] }, { "title": "Regulation of STAT3 activity by G16-coupled receptors.", "journal": "Biochemical and biophysical research communications", "date": "2003", "authors": "Wu EH, Lo RK, Wong YH", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "12670499", "url": "https://glygen.org/publication/PubMed/12670499" } ] }, { "title": "Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway.", "journal": "Experimental hematology", "date": "2003", "authors": "Wierenga AT, Vogelzang I, Eggen BJ, Vellenga E", "evidence": [ { "database": "UniProtKB", "id": "P40763", "url": "https://www.uniprot.org/uniprotkb/P40763" }, { "database": "iPTMnet", "id": "P40763-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763-1" } ], "reference": [ { "type": "PubMed", "id": "12763138", "url": "https://glygen.org/publication/PubMed/12763138" } ] }, { "title": "Sequence-specific peptide aptamers, interacting with the intracellular domain of the epidermal growth factor receptor, interfere with Stat3 activation and inhibit the growth of tumor cells.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Buerger C, Nagel-Wolfrum K, Kunz C, Wittig I, Butz K, Hoppe-Seyler F, Groner B", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "12842895", "url": "https://glygen.org/publication/PubMed/12842895" } ] }, { "title": "Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells.", "journal": "BMC cancer", "date": "2003", "authors": "Konnikova L, Kotecki M, Kruger MM, Cochran BH", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "13678425", "url": "https://glygen.org/publication/PubMed/13678425" } ] }, { "title": "Real time analysis of STAT3 nucleocytoplasmic shuttling.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Pranada AL, Metz S, Herrmann A, Heinrich PC, Muller-Newen G", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "14701810", "url": "https://glygen.org/publication/PubMed/14701810" } ] }, { "title": "Pyk2 amplifies epidermal growth factor and c-Src-induced Stat3 activation.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Shi CS, Kehrl JH", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "14963038", "url": "https://glygen.org/publication/PubMed/14963038" } ] }, { "title": "Induction of gp130-related cytokines and activation of JAK2/STAT3 pathway in astrocytes precedes up-regulation of glial fibrillary acidic protein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of neurodegeneration: key signaling pathway for astrogliosis in vivo?", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Sriram K, Benkovic SA, Hebert MA, Miller DB, O'Callaghan JP", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "14996842", "url": "https://glygen.org/publication/PubMed/14996842" } ] }, { "title": "Hepatocyte growth factor induces Mcl-1 in primary human hepatocytes and inhibits CD95-mediated apoptosis via Akt.", "journal": "Hepatology (Baltimore, Md.)", "date": "2004", "authors": "Schulze-Bergkamen H, Brenner D, Krueger A, Suess D, Fas SC, Frey CR, Dax A, Zink D, Buchler P, Muller M, Krammer PH", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "14999683", "url": "https://glygen.org/publication/PubMed/14999683" } ] }, { "title": "Molecular analysis of signaling events mediated by the cytoplasmic domain of leukemia inhibitory factor receptor alpha subunit.", "journal": "Molecular and cellular biochemistry", "date": "2004", "authors": "Liu H, Liu S, Tang S, Ji K, Wang F, Hu S", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "15030166", "url": "https://glygen.org/publication/PubMed/15030166" } ] }, { "title": "Oxidized phospholipids increase interleukin 8 (IL-8) synthesis by activation of the c-src/signal transducers and activators of transcription (STAT)3 pathway.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Yeh M, Gharavi NM, Choi J, Hsieh X, Reed E, Mouillesseaux KP, Cole AL, Reddy ST, Berliner JA", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "15143062", "url": "https://glygen.org/publication/PubMed/15143062" } ] }, { "title": "Signal transducer and activator of transcription 3 activation by the delta-opioid receptor via Galpha14 involves multiple intermediates.", "journal": "Molecular pharmacology", "date": "2004", "authors": "Lo RK, Wong YH", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "15155836", "url": "https://glygen.org/publication/PubMed/15155836" } ] }, { "title": "Complex regulation of signal transducers and activators of transcription 3 activation in normal and malignant keratinocytes.", "journal": "Cancer research", "date": "2004", "authors": "Quadros MR, Peruzzi F, Kari C, Rodeck U", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "15173005", "url": "https://glygen.org/publication/PubMed/15173005" } ] }, { "title": "STAT3 phosphorylation in injured axons before sensory and motor neuron nuclei: potential role for STAT3 as a retrograde signaling transcription factor.", "journal": "The Journal of comparative neurology", "date": "2004", "authors": "Lee N, Neitzel KL, Devlin BK, MacLennan AJ", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "15174071", "url": "https://glygen.org/publication/PubMed/15174071" } ] }, { "title": "IFN-alpha5 mediates stronger Tyk2-stat-dependent activation and higher expression of 2',5'-oligoadenylate synthetase than IFN-alpha2 in liver cells.", "journal": "Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research", "date": "2004", "authors": "Larrea E, Aldabe R, Riezu-Boj JI, Guitart A, Civeira MP, Prieto J, Baixeras E", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "15320963", "url": "https://glygen.org/publication/PubMed/15320963" } ] }, { "title": "Tyrosine dephosphorylation of STAT3 in SARS coronavirus-infected Vero E6 cells.", "journal": "FEBS letters", "date": "2004-11-05", "authors": "Mizutani Tetsuya, Fukushi Shuetsu, Murakami Masaaki, Hirano Toshio, Saijo Masayuki, Kurane Ichiro, Morikawa Shigeru", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "15527783", "url": "https://glygen.org/publication/PubMed/15527783" } ] }, { "title": "Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation.", "journal": "Cancer research", "date": "2005", "authors": "Yang J, Chatterjee-Kishore M, Staugaitis SM, Nguyen H, Schlessinger K, Levy DE, Stark GR", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "15705894", "url": "https://glygen.org/publication/PubMed/15705894" } ] }, { "title": "RET-familial medullary thyroid carcinoma mutants Y791F and S891A activate a Src/JAK/STAT3 pathway, independent of glial cell line-derived neurotrophic factor.", "journal": "Cancer research", "date": "2005", "authors": "Plaza Menacho I, Koster R, van der Sloot AM, Quax WJ, Osinga J, van der Sluis T, Hollema H, Burzynski GM, Gimm O, Buys CH, Eggen BJ, Hofstra RM", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "15753368", "url": "https://glygen.org/publication/PubMed/15753368" } ] }, { "title": "ICAM-1 induction by TNFalpha and IL-6 is mediated by distinct pathways via Rac in endothelial cells.", "journal": "Journal of biomedical science", "date": "2005", "authors": "Wung B S, Ni C W, Wang D L", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "15864742", "url": "https://glygen.org/publication/PubMed/15864742" } ] }, { "title": "STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells.", "journal": "The Biochemical journal", "date": "2005", "authors": "Bhattacharya S, Ray RM, Johnson LR", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" }, { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "16048438", "url": "https://glygen.org/publication/PubMed/16048438" } ] }, { "title": "Evaluation of potential Stat3-regulated genes in human breast cancer.", "journal": "Biochemical and biophysical research communications", "date": "2005", "authors": "Hsieh FC, Cheng G, Lin J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": 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"https://glygen.org/publication/PubMed/16247467" } ] }, { "title": "Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer.", "journal": "British journal of cancer", "date": "2005", "authors": "Lin HJ, Hsieh FC, Song H, Lin J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "16288304", "url": "https://glygen.org/publication/PubMed/16288304" } ] }, { "title": "Trichostatin A increases the thermosensitivity of human glioblastoma A172 cells.", "journal": "Neuroscience letters", "date": "2006", "authors": "Baek SY, Kim SR, Bae MK, Hwang JW, Kim JS, Choi YH, Wee HJ, Kim BS, Kim JB, Yoon S, Bae SK", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "16384639", "url": "https://glygen.org/publication/PubMed/16384639" } ] }, { "title": "Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin.", "journal": "The Journal of cell biology", "date": "2006", "authors": "Ng DC, Lin BH, Lim CP, Huang G, Zhang T, Poli V, Cao X", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "16401721", "url": "https://glygen.org/publication/PubMed/16401721" } ] }, { "title": "15-Deoxy-Delta(12,14)-prostaglandin J(2) suppresses IL-6-induced STAT3 phosphorylation via electrophilic reactivity in endothelial cells.", "journal": "Life sciences", "date": "2006", "authors": "Wung BS, Wu CC, Hsu MC, Hsieh CW", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "16413037", "url": "https://glygen.org/publication/PubMed/16413037" } ] }, { "title": "Systemic evaluation of total Stat3 and Stat3 tyrosine phosphorylation in normal human tissues.", "journal": "Experimental and molecular pathology", "date": "2006", "authors": "Chen CL, Hsieh FC, Lin J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "16427042", "url": "https://glygen.org/publication/PubMed/16427042" } ] }, { "title": "A growth-suppressive function for the c-fes protein-tyrosine kinase in colorectal cancer.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Delfino FJ, Stevenson H, Smithgall TE", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "16455651", "url": "https://glygen.org/publication/PubMed/16455651" } ] }, { "title": "STAT3 is activated in a subset of the Ewing sarcoma family of tumours.", "journal": "The Journal of pathology", "date": "2006", "authors": "Lai R, Navid F, Rodriguez-Galindo C, Liu T, Fuller CE, Ganti R, Dien J, Dalton J, Billups C, Khoury JD", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "16463269", "url": "https://glygen.org/publication/PubMed/16463269" } ] }, { "title": "Active Stat3 is required for survival of human squamous cell carcinoma cells in serum-free conditions.", "journal": "Molecular cancer", "date": "2006", "authors": "Yin W, Cheepala S, Roberts JN, Syson-Chan K, DiGiovanni J, Clifford JL", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "16603078", "url": "https://glygen.org/publication/PubMed/16603078" } ] }, { "title": "Photochemopreventive effect of pomegranate fruit extract on UVA-mediated activation of cellular pathways in normal human epidermal keratinocytes.", "journal": "Photochemistry and photobiology", "date": "2006", "authors": "Syed DN, Malik A, Hadi N, Sarfaraz S, Afaq F, Mukhtar H", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "16613491", "url": "https://glygen.org/publication/PubMed/16613491" } ] }, { "title": "Stat3 contributes to keloid pathogenesis via promoting collagen production, cell proliferation and migration.", "journal": "Oncogene", "date": "2006", "authors": "Lim CP, Phan TT, Lim IJ, Cao X", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "16619044", "url": "https://glygen.org/publication/PubMed/16619044" } ] }, { "title": "Luteolin promotes degradation in signal transducer and activator of transcription 3 in human hepatoma cells: an implication for the antitumor potential of flavonoids.", "journal": "Cancer research", "date": "2006", "authors": "Selvendiran K, Koga H, Ueno T, Yoshida T, Maeyama M, Torimura T, Yano H, Kojiro M, Sata M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "16651438", "url": "https://glygen.org/publication/PubMed/16651438" } ] }, { "title": "Phosphorylation of STAT3 serine-727 by cyclin-dependent kinase 1 is critical for nocodazole-induced mitotic arrest.", "journal": "Biochemistry", "date": "2006", "authors": "Shi X, Zhang H, Paddon H, Lee G, Cao X, Pelech S", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "16669628", "url": "https://glygen.org/publication/PubMed/16669628" } ] }, { "title": "The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells.", "journal": "The Journal of experimental medicine", "date": "2006", "authors": "Sumimoto H, Imabayashi F, Iwata T, Kawakami Y", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "16801397", "url": "https://glygen.org/publication/PubMed/16801397" } ] }, { "title": "BCR-ABL activates STAT3 via JAK and MEK pathways in human cells.", "journal": "British journal of haematology", "date": "2006", "authors": "Coppo P, Flamant S, De Mas V, Jarrier P, Guillier M, Bonnet ML, Lacout C, Guilhot F, Vainchenker W, Turhan AG", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "16846476", "url": "https://glygen.org/publication/PubMed/16846476" } ] }, { "title": "An orally administered multitarget tyrosine kinase inhibitor, SU11248, is a novel potent inhibitor of thyroid oncogenic RET/papillary thyroid cancer kinases.", "journal": "The Journal of clinical endocrinology and metabolism", "date": "2006", "authors": "Kim DW, Jo YS, Jung HS, Chung HK, Song JH, Park KC, Park SH, Hwang JH, Rha SY, Kweon GR, Lee SJ, Jo KW, Shong M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "16849418", "url": "https://glygen.org/publication/PubMed/16849418" } ] }, { "title": "Monocyte 15-lipoxygenase expression is regulated by a novel cytosolic signaling complex with protein kinase C delta and tyrosine-phosphorylated Stat3.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2006", "authors": "Bhattacharjee A, Xu B, Frank DA, Feldman GM, Cathcart MK", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": 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Cell physiology", "date": "2007", "authors": "Xu F, Mukhopadhyay S, Sehgal PB", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "17670892", "url": "https://glygen.org/publication/PubMed/17670892" } ] }, { "title": "Tumor suppressor LKB1 inhibits activation of signal transducer and activator of transcription 3 (STAT3) by thyroid oncogenic tyrosine kinase rearranged in transformation (RET)/papillary thyroid carcinoma (PTC).", "journal": "Molecular endocrinology (Baltimore, Md.)", "date": "2007", "authors": "Kim DW, Chung HK, Park KC, Hwang JH, Jo YS, Chung J, Kalvakolanu DV, Resta N, Shong M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "17761947", "url": "https://glygen.org/publication/PubMed/17761947" } ] }, { "title": "Responses of cancer 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inflammatory signaling by activation of STAT3/PIAS3 in human endothelial cells.", "journal": "Journal of virology", "date": "2008", "authors": "Duechting A, Tschope C, Kaiser H, Lamkemeyer T, Tanaka N, Aberle S, Lang F, Torresi J, Kandolf R, Bock CT", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "18550668", "url": "https://glygen.org/publication/PubMed/18550668" } ] }, { "title": "Caspase-mediated cleavage of the signal-transducing IL-6 receptor subunit gp130.", "journal": "Archives of biochemistry and biophysics", "date": "2008", "authors": "Graf D, Haselow K, Munks I, Bode JG, Haussinger D", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "18593565", "url": "https://glygen.org/publication/PubMed/18593565" } ] }, { "title": "STAT3 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suppressing activation of signal transducer and activator of transcription 3.", "journal": "Carcinogenesis", "date": "2011", "authors": "Kim SH, Nagalingam A, Saxena NK, Singh SV, Sharma D", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21163886", "url": "https://glygen.org/publication/PubMed/21163886" } ] }, { "title": "A helminth immunomodulator exploits host signaling events to regulate cytokine production in macrophages.", "journal": "PLoS pathogens", "date": "2011", "authors": "Klotz C, Ziegler T, Figueiredo AS, Rausch S, Hepworth MR, Obsivac N, Sers C, Lang R, Hammerstein P, Lucius R, Hartmann S", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21253577", "url": "https://glygen.org/publication/PubMed/21253577" } ] }, { "title": 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"https://glygen.org/publication/PubMed/21311975" } ] }, { "title": "Characterization of molecular recognition of STAT3 SH2 domain inhibitors through molecular simulation.", "journal": "Journal of molecular recognition : JMR", "date": "2011", "authors": "Park IH, Li C", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21360612", "url": "https://glygen.org/publication/PubMed/21360612" } ] }, { "title": "Antitumor activity of a novel small molecule STAT3 inhibitor against a human lymphoma cell line with high STAT3 activation.", "journal": "International journal of oncology", "date": "2011", "authors": "Ashizawa T, Miyata H, Ishii H, Oshita C, Matsuno K, Masuda Y, Furuya T, Okawara T, Otsuka M, Ogo N, Asai A, Akiyama Y", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21369699", "url": "https://glygen.org/publication/PubMed/21369699" } ] }, { "title": "JAK/STAT signaling and human in vitro myogenesis.", "journal": "BMC physiology", "date": "2011", "authors": "Trenerry MK, Della Gatta PA, Cameron-Smith D", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21388555", "url": "https://glygen.org/publication/PubMed/21388555" } ] }, { "title": "Novel small molecule, XZH-5, inhibits constitutive and interleukin-6-induced STAT3 phosphorylation in human rhabdomyosarcoma cells.", "journal": "Cancer science", "date": "2011", "authors": "Liu A, Liu Y, Xu Z, Yu W, Wang H, Li C, Lin J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21435102", "url": "https://glygen.org/publication/PubMed/21435102" } ] }, { "title": "The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines.", "journal": "BMC cancer", "date": "2011", "authors": "Fossey SL, Bear MD, Lin J, Li C, Schwartz EB, Li PK, Fuchs JR, Fenger J, Kisseberth WC, London CA", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21443800", "url": "https://glygen.org/publication/PubMed/21443800" } ] }, { "title": "A STAT3-decoy oligonucleotide induces cell death in a human colorectal carcinoma cell line by blocking nuclear transfer of STAT3 and STAT3-bound NF-kappaB.", "journal": "BMC cell biology", "date": "2011", "authors": "Souissi I, Najjar I, Ah-Koon L, Schischmanoff PO, Lesage D, Le Coquil S, Roger C, Dusanter-Fourt I, Varin-Blank N, Cao A, Metelev V, Baran-Marszak F, Fagard R", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21486470", "url": "https://glygen.org/publication/PubMed/21486470" } ] }, { "title": "Gambogic acid inhibits STAT3 phosphorylation through activation of protein tyrosine phosphatase SHP-1: potential role in proliferation and apoptosis.", "journal": "Cancer prevention research (Philadelphia, Pa.)", "date": "2011", "authors": "Prasad S, Pandey MK, Yadav VR, Aggarwal BB", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21490133", "url": "https://glygen.org/publication/PubMed/21490133" } ] }, { "title": "Caspase-8 cleavage of the interleukin-21 (IL-21) receptor is a negative feedback regulator of IL-21 signaling.", "journal": "FEBS letters", "date": "2011", "authors": "Akagi T, Shimizu K, Takahama S, Iwasaki T, Sakamaki K, Endo Y, Sawasaki T", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21524651", "url": "https://glygen.org/publication/PubMed/21524651" } ] }, { "title": "The small molecule, LLL12, inhibits STAT3 phosphorylation and induces apoptosis in medulloblastoma and glioblastoma cells.", "journal": "PloS one", "date": "2011", "authors": "Ball S, Li C, Li PK, Lin J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21526200", "url": "https://glygen.org/publication/PubMed/21526200" } ] }, { "title": "Inhibition of Stat3 activation by sanguinarine suppresses prostate cancer cell growth and invasion.", "journal": "The Prostate", "date": "2012", "authors": "Sun M, Liu C, Nadiminty N, Lou W, Zhu Y, Yang J, Evans CP, Zhou Q, Gao AC", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21538419", "url": "https://glygen.org/publication/PubMed/21538419" } ] }, { "title": "A novel requirement for Janus kinases as mediators of drug resistance induced by fibroblast growth factor-2 in human cancer cells.", "journal": "PloS one", "date": "2011", "authors": "Carmo CR, Lyons-Lewis J, Seckl MJ, Costa-Pereira AP", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21625473", "url": "https://glygen.org/publication/PubMed/21625473" } ] }, { "title": "Dynamics of the STAT3 transcription factor: nuclear import dependent on Ran and importin-beta1.", "journal": "PloS one", "date": "2011", "authors": "Cimica V, Chen HC, Iyer JK, Reich NC", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21625522", "url": "https://glygen.org/publication/PubMed/21625522" } ] }, { "title": "Two naturally occurring terpenes, dehydrocostuslactone and costunolide, decrease intracellular GSH content and inhibit STAT3 activation.", "journal": "PloS one", "date": "2011", "authors": "Butturini E, Cavalieri E, de Prati AC, Darra E, Rigo A, Shoji K, Murayama N, Yamazaki H, Watanabe Y, Suzuki H, Mariotto S", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21625597", "url": "https://glygen.org/publication/PubMed/21625597" } ] }, { "title": "An intracytoplasmic IL-10 receptor variant permits rapid reduction in STAT3 activation.", "journal": "Genes and immunity", "date": "2011", "authors": "Finsterbusch M, Khare V, Campregher C, Evstatiev R, Gasche C", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21654841", "url": "https://glygen.org/publication/PubMed/21654841" } ] }, { "title": "MicroRNA and target protein patterns reveal physiopathological features of glioma subtypes.", "journal": "PloS one", "date": "2011", "authors": "Lages E, Guttin A, El Atifi M, Ramus C, Ipas H, Dupre I, Rolland D, Salon C, Godfraind C, deFraipont F, Dhobb M, Pelletier L, Wion D, Gay E, Berger F, Issartel JP", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21655185", "url": "https://glygen.org/publication/PubMed/21655185" } ] }, { "title": "Deactivation of signal transducer and activator of transcription 3 reverses chemotherapeutics resistance of leukemia cells via down-regulating P-gp.", "journal": "PloS one", "date": "2011", "authors": "Zhang X, Xiao W, Wang L, Tian Z, Zhang J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21677772", "url": "https://glygen.org/publication/PubMed/21677772" } ] }, { "title": "Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells.", "journal": "Oncogene", "date": "2012", "authors": "Bourguignon LY, Earle C, Wong G, Spevak CC, Krueger K", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21685938", "url": "https://glygen.org/publication/PubMed/21685938" } ] }, { "title": "Stat3 and CCAAT/enhancer binding protein beta (C/EBP-beta) regulate Jab1/CSN5 expression in mammary carcinoma cells.", "journal": "Breast cancer research : BCR", "date": "2011", "authors": "Shackleford TJ, Zhang Q, Tian L, Vu TT, Korapati AL, Baumgartner AM, Le XF, Liao WS, Claret FX", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21689417", "url": "https://glygen.org/publication/PubMed/21689417" } ] }, { "title": "Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas.", "journal": "The Journal of experimental medicine", "date": "2011", "authors": "Pilati C, Amessou M, Bihl MP, Balabaud C, Nhieu JT, Paradis V, Nault JC, Izard T, Bioulac-Sage P, Couchy G, Poussin K, Zucman-Rossi J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21690253", "url": "https://glygen.org/publication/PubMed/21690253" } ] }, { "title": "Targeting colon cancer stem cells using a new curcumin analogue, GO-Y030.", "journal": "British journal of cancer", "date": "2011", "authors": "Lin L, Liu Y, Li H, Li PK, Fuchs J, Shibata H, Iwabuchi Y, Lin J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21694723", "url": "https://glygen.org/publication/PubMed/21694723" } ] }, { "title": "Differential roles of STAT3 depending on the mechanism of STAT3 activation in gastric cancer cells.", "journal": "British journal of cancer", "date": "2011", "authors": "Okamoto W, Okamoto I, Arao T, Yanagihara K, Nishio K, Nakagawa K", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21730976", "url": "https://glygen.org/publication/PubMed/21730976" } ] }, { "title": "IL-6-mediated activation of Stat3alpha prevents trauma/hemorrhagic shock-induced liver inflammation.", "journal": "PloS one", "date": "2011", "authors": "Moran A, Thacker SA, Arikan AA, Mastrangelo MA, Wu Y, Yu B, Tweardy DJ", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21738667", "url": "https://glygen.org/publication/PubMed/21738667" } ] }, { "title": "MUC16 induced rapid G2/M transition via interactions with JAK2 for increased proliferation and anti-apoptosis in breast cancer cells.", "journal": "Oncogene", "date": "2012", "authors": "Lakshmanan I, Ponnusamy MP, Das S, Chakraborty S, Haridas D, Mukhopadhyay P, Lele SM, Batra SK", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21785467", "url": "https://glygen.org/publication/PubMed/21785467" } ] }, { "title": "STAT3 activation in skeletal muscle links muscle wasting and the acute phase response in cancer cachexia.", "journal": "PloS one", "date": "2011", "authors": "Bonetto A, Aydogdu T, Kunzevitzky N, Guttridge DC, Khuri S, Koniaris LG, Zimmers TA", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21799891", "url": "https://glygen.org/publication/PubMed/21799891" } ] }, { "title": "Heteroarylketones inhibit astroglial interleukin-6 expression via a STAT3/NF-kappaB signaling pathway.", "journal": "Journal of neuroinflammation", "date": "2011", "authors": "Schulz I, Engel C, Niestroj AJ, Zeitschel U, Menge K, Kehlen A, Meyer A, Rossner S, Demuth HU", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21801384", "url": "https://glygen.org/publication/PubMed/21801384" } ] }, { "title": "Cross-talk between phospho-STAT3 and PLCgamma1 plays a critical role in colorectal tumorigenesis.", "journal": "Molecular cancer research : MCR", "date": "2011", "authors": "Zhang P, Zhao Y, Zhu X, Sedwick D, Zhang X, Wang Z", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21840932", "url": "https://glygen.org/publication/PubMed/21840932" } ] }, { "title": "Adenovirus-mediated delivery of bFGF small interfering RNA reduces STAT3 phosphorylation and induces the depolarization of mitochondria and apoptosis in glioma cells U251.", "journal": "Journal of experimental & clinical cancer research : CR", "date": "2011-09-09", "authors": "Liu Jun, Xu Xinnv, Feng Xuequan, Zhang Biao, Wang Jinhuan", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21906308", "url": "https://glygen.org/publication/PubMed/21906308" } ] }, { "title": "Jak2-Independent Activation of Stat3 by Intracellular Angiotensin II in Human Mesangial Cells.", "journal": "Journal of signal transduction", "date": "2011", "authors": "Singh R", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21915376", "url": "https://glygen.org/publication/PubMed/21915376" } ] }, { "title": "Lithium suppresses astrogliogenesis by neural stem and progenitor cells by inhibiting STAT3 pathway independently of glycogen synthase kinase 3 beta.", "journal": "PloS one", "date": "2011", "authors": "Zhu Z, Kremer P, Tadmori I, Ren Y, Sun D, He X, Young W", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21931595", "url": "https://glygen.org/publication/PubMed/21931595" } ] }, { "title": "Interleukin-6 autocrine signaling mediates melatonin MT(1/2) receptor-induced STAT3 Tyr(705) phosphorylation.", "journal": "Journal of pineal research", "date": "2012", "authors": "Lau WW, Ng JK, Lee MM, Chan AS, Wong YH", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21954831", "url": "https://glygen.org/publication/PubMed/21954831" } ] }, { "title": "Benzyl isothiocyanate suppresses pancreatic tumor angiogenesis and invasion by inhibiting HIF-alpha/VEGF/Rho-GTPases: pivotal role of STAT-3.", "journal": "PloS one", "date": "2011", "authors": "Boreddy SR, Sahu RP, Srivastava SK", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22016776", "url": "https://glygen.org/publication/PubMed/22016776" } ] }, { "title": "Phosphorylation of STAT3 in head and neck cancer requires p38 MAPKinase, whereas phosphorylation of STAT1 occurs via a different signaling pathway.", "journal": "Anticancer research", "date": "2011", "authors": "Riebe C, Pries R, Schroeder KN, Wollenberg B", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22110204", "url": "https://glygen.org/publication/PubMed/22110204" } ] }, { "title": "Calyculin A reveals serine/threonine phosphatase protein phosphatase 1 as a regulatory nodal point in canonical signal transducer and activator of transcription 3 signaling of human microvascular endothelial cells.", "journal": "Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research", "date": "2012", "authors": "Zgheib C, Zouein FA, Chidiac R, Kurdi M, Booz GW", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22142222", "url": "https://glygen.org/publication/PubMed/22142222" } ] }, { "title": "The FGFR4-G388R polymorphism promotes mitochondrial STAT3 serine phosphorylation to facilitate pituitary growth hormone cell tumorigenesis.", "journal": "PLoS genetics", "date": "2011", "authors": "Tateno T, Asa SL, Zheng L, Mayr T, Ullrich A, Ezzat S", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22174695", "url": "https://glygen.org/publication/PubMed/22174695" } ] }, { "title": "Antitumor activity of a novel oncrasin analogue is mediated by JNK activation and STAT3 inhibition.", "journal": "PloS one", "date": "2011", "authors": "Guo W, Wu S, Wang L, Wei X, Liu X, Wang J, Lu Z, Hollingshead M, Fang B", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22174819", "url": "https://glygen.org/publication/PubMed/22174819" } ] }, { "title": "The peroxisome proliferator-activated receptor (PPAR) beta/delta agonist GW501516 inhibits IL-6-induced signal transducer and activator of transcription 3 (STAT3) activation and insulin resistance in human liver cells.", "journal": "Diabetologia", "date": "2012", "authors": "Serrano-Marco L, Barroso E, El Kochairi I, Palomer X, Michalik L, Wahli W, Vazquez-Carrera M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22179221", "url": "https://glygen.org/publication/PubMed/22179221" } ] }, { "title": "Pyrvinium pamoate inhibits proliferation of myeloma/erythroleukemia cells by suppressing mitochondrial respiratory complex I and STAT3.", "journal": "Cancer letters", "date": "2012", "authors": "Harada Y, Ishii I, Hatake K, Kasahara T", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22210382", "url": "https://glygen.org/publication/PubMed/22210382" } ] }, { "title": "Characterization of the cytokine profile of platelet rich plasma (PRP) and PRP-induced cell proliferation and migration: Upregulation of matrix metalloproteinase-1 and -9 in HaCaT cells.", "journal": "The Korean journal of hematology", "date": "2011", "authors": "Park HB, Yang JH, Chung KH", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22259633", "url": "https://glygen.org/publication/PubMed/22259633" } ] }, { "title": "14-3-3zeta interacts with stat3 and regulates its constitutive activation in multiple myeloma cells.", "journal": "PloS one", "date": "2012", "authors": "Zhang J, Chen F, Li W, Xiong Q, Yang M, Zheng P, Li C, Pei J, Ge F", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22279540", "url": "https://glygen.org/publication/PubMed/22279540" } ] }, { "title": "Diindolylmethane suppresses ovarian cancer growth and potentiates the effect of cisplatin in tumor mouse model by targeting signal transducer and activator of transcription 3 (STAT3).", "journal": "BMC medicine", "date": "2012", "authors": "Kandala PK, Srivastava SK", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22280969", "url": "https://glygen.org/publication/PubMed/22280969" } ] }, { "title": "(-)-Epigallocatechin gallate induces Fas/CD95-mediated apoptosis through inhibiting constitutive and IL-6-induced JAK/STAT3 signaling in head and neck squamous cell carcinoma cells.", "journal": "Journal of agricultural and food chemistry", "date": "2012", "authors": "Lin HY, Hou SC, Chen SC, Kao MC, Yu CC, Funayama S, Ho CT, Way TD", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22313388", "url": "https://glygen.org/publication/PubMed/22313388" } ] }, { "title": "STAT3 Regulates Proliferation and Immunogenicity of the Ewing Family of Tumors In Vitro.", "journal": "Sarcoma", "date": "2012", "authors": "Behjati S, Basu BP, Wallace R, Bier N, Sebire N, Hasan F, Anderson J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22315522", "url": 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Arturo, Rauter Ingrid, Benson Halli, Schneider Lynda, Baxi Sachin, Recher Mike, Notarangelo Luigi D, Wakim Rima, Dbaibo Ghassan, Dasouki Majed, Al-Herz Waleed, Barlan Isil, Baris Safa, Kutukculer Necil, Ochs Hans D, Plebani Alessandro, Kanariou Maria, Lefranc Gerard, Reisli Ismail, Fitzgerald Katherine A, Golenbock Douglas, Manis John, Keles Sevgi, Ceja Reuben, Chatila Talal A, Geha Raif S", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22581261", "url": "https://glygen.org/publication/PubMed/22581261" } ] }, { "title": "NF-kappaB2 mutation targets survival, proliferation and differentiation pathways in the pathogenesis of plasma cell tumors.", "journal": "BMC cancer", "date": "2012", "authors": "McCarthy BA, Yang L, Ding J, Ren M, King W, ElSalanty M, Zakhary I, Sharawy M, Cui H, Ding HF", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": 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J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22754353", "url": "https://glygen.org/publication/PubMed/22754353" } ] }, { "title": "Selective STAT3-alpha or -beta expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes.", "journal": "The Biochemical journal", "date": "2012", "authors": "Ng IH, Ng DC, Jans DA, Bogoyevitch MA", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22799634", "url": "https://glygen.org/publication/PubMed/22799634" } ] }, { "title": "HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells.", "journal": "Cancer biology & therapy", "date": "2012", "authors": "Tierney BJ, McCann GA, Cohn DE, Eisenhauer E, Sudhakar M, Kuppusamy P, Hideg K, Selvendiran K", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22801507", "url": "https://glygen.org/publication/PubMed/22801507" } ] }, { "title": "Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer models.", "journal": "BMC medicine", "date": "2012", "authors": "Gupta P, Srivastava SK", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22824293", "url": "https://glygen.org/publication/PubMed/22824293" } ] }, { "title": "Redeployment-based drug screening identifies the anti-helminthic niclosamide as anti-myeloma therapy that also reduces free light chain production.", "journal": "Blood cancer journal", "date": "2011", "authors": "Khanim FL, Merrick BA, Giles HV, Jankute M, Jackson JB, Giles LJ, Birtwistle J, Bunce CM, Drayson MT", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22829072", "url": "https://glygen.org/publication/PubMed/22829072" } ] }, { "title": "Inhibition of STAT3 reverses drug resistance acquired in temozolomide-resistant human glioma cells.", "journal": "Oncology letters", "date": "2011", "authors": "Lee ES, Ko KK, Joe YA, Kang SG, Hong YK", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22870139", "url": "https://glygen.org/publication/PubMed/22870139" } ] }, { "title": "Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines.", "journal": "PloS one", "date": "2012", "authors": "Bill MA, Nicholas C, Mace TA, Etter JP, Li C, Schwartz EB, Fuchs JR, Young GS, Lin L, Lin J, He L, Phelps M, Li PK, Lesinski GB", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22899991", "url": "https://glygen.org/publication/PubMed/22899991" } ] }, { "title": "Acyloxy nitroso compounds inhibit LIF signaling in endothelial cells and cardiac myocytes: evidence that STAT3 signaling is redox-sensitive.", "journal": "PloS one", "date": "2012", "authors": "Zgheib C, Kurdi M, Zouein FA, Gunter BW, Stanley BA, Zgheib J, Romero DG, King SB, Paolocci N, Booz GW", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22905257", "url": "https://glygen.org/publication/PubMed/22905257" } ] }, { "title": "Inhibition of STAT signalling in bladder cancer by 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"title": "Calpain/SHP-1 interaction by honokiol dampening peritoneal dissemination of gastric cancer in nu/nu mice.", "journal": "PloS one", "date": "2012", "authors": "Liu SH, Wang KB, Lan KH, Lee WJ, Pan HC, Wu SM, Peng YC, Chen YC, Shen CC, Cheng HC, Liao KK, Sheu ML", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22937084", "url": "https://glygen.org/publication/PubMed/22937084" } ] }, { "title": "Sorafenib and its derivative SC-49 sensitize hepatocellular carcinoma cells to CS-1008, a humanized anti-TNFRSF10B (DR5) antibody.", "journal": "British journal of pharmacology", "date": "2013", "authors": "Chen KF, Chen HL, Shiau CW, Liu CY, Chu PY, Tai WT, Ichikawa K, Chen PJ, Cheng AL", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": 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Weng CM, Yu CC, Hsu MJ, Yu MC, Ma HP, Wu CH, Hong CY, Kuo ML, Lin CH", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23108098", "url": "https://glygen.org/publication/PubMed/23108098" } ] }, { "title": "CCR1-mediated STAT3 tyrosine phosphorylation and CXCL8 expression in THP-1 macrophage-like cells involve pertussis toxin-insensitive Galpha(14/16) signaling and IL-6 release.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2012", "authors": "Lee MM, Chui RK, Tam IY, Lau AH, Wong YH", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23125416", "url": "https://glygen.org/publication/PubMed/23125416" } ] }, { "title": "Spirooxindole derivative SOID-8 induces apoptosis associated with inhibition of JAK2/STAT3 signaling in melanoma cells.", "journal": "PloS one", "date": "2012", "authors": "Tian Y, Nam S, Liu L, Yakushijin F, Yakushijin K, Buettner R, Liang W, Yang F, Ma Y, Horne D, Jove R", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23166634", "url": "https://glygen.org/publication/PubMed/23166634" } ] }, { "title": "Centrosomal localization of the psoriasis candidate gene product, CCHCR1, supports a role in cytoskeletal organization.", "journal": "PloS one", "date": "2012", "authors": "Tervaniemi MH, Siitonen HA, Soderhall C, Minhas G, Vuola J, Tiala I, Sormunen R, Samuelsson L, Suomela S, Kere J, Elomaa O", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23189171", "url": "https://glygen.org/publication/PubMed/23189171" } ] }, { "title": "Protective role of STAT3 in NMDA and glutamate-induced neuronal death: negative regulatory effect of SOCS3.", "journal": "PloS one", "date": "2012", "authors": "Park KW, Nozell SE, Benveniste EN", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23226414", "url": "https://glygen.org/publication/PubMed/23226414" } ] }, { "title": "Resveratrol prevents EBV transformation and inhibits the outgrowth of EBV-immortalized human B cells.", "journal": "PloS one", "date": "2012", "authors": "Espinoza JL, Takami A, Trung LQ, Kato S, Nakao S", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23251493", "url": "https://glygen.org/publication/PubMed/23251493" } ] }, { "title": "Morin inhibits STAT3 tyrosine 705 phosphorylation in tumor cells through activation of protein tyrosine phosphatase SHP1.", "journal": "Biochemical pharmacology", "date": "2013", "authors": "Gupta SC, Phromnoi K, Aggarwal BB", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23279849", "url": "https://glygen.org/publication/PubMed/23279849" } ] }, { "title": "The IL-6 trans-signaling-STAT3 pathway mediates ECM and cellular proliferation in fibroblasts from hypertrophic scar.", "journal": "The Journal of investigative dermatology", "date": "2013", "authors": "Ray S, Ju X, Sun H, Finnerty CC, Herndon DN, Brasier AR", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23303450", "url": "https://glygen.org/publication/PubMed/23303450" } ] }, { "title": "EGFR-STAT3 signaling promotes formation of malignant peripheral nerve sheath 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"title": "PTTG acts as a STAT3 target gene for colorectal cancer cell growth and motility.", "journal": "Oncogene", "date": "2014", "authors": "Zhou C, Tong Y, Wawrowsky K, Melmed S", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23416975", "url": "https://glygen.org/publication/PubMed/23416975" } ] }, { "title": "Identification and characterization of small molecule inhibitors of signal transducer and activator of transcription 3 (STAT3) signaling pathway by virtual screening.", "journal": "Bioorganic & medicinal chemistry letters", "date": "2013", "authors": "Zhang M, Zhu W, Ding N, Zhang W, Li Y", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23434226", "url": "https://glygen.org/publication/PubMed/23434226" } ] }, { "title": 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Katz D, Daum H, Hamburger T, Maly B, Allweis TM, Peretz T", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23446809", "url": "https://glygen.org/publication/PubMed/23446809" } ] }, { "title": "Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor.", "journal": "Oncogene", "date": "2014", "authors": "Becker TM, Boyd SC, Mijatov B, Gowrishankar K, Snoyman S, Pupo GM, Scolyer RA, Mann GJ, Kefford RF, Zhang XD, Rizos H", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" }, { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23455323", "url": "https://glygen.org/publication/PubMed/23455323" } ] }, { "title": "pSTAT3: a target biomarker to study the pharmacology of the anti-IL-21R antibody ATR-107 in human whole blood.", "journal": "Journal of translational medicine", "date": "2013", "authors": "Zhu M, Pleasic-Williams S, Lin TH, Wunderlich DA, Cheng JB, Masferrer JL", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23496892", "url": "https://glygen.org/publication/PubMed/23496892" } ] }, { "title": "Critical role for the advanced glycation end-products receptor in pulmonary arterial hypertension etiology.", "journal": "Journal of the American Heart Association", "date": "2013", "authors": "Meloche J, Courchesne A, Barrier M, Carter S, Bisserier M, Paulin R, Lauzon-Joset JF, Breuils-Bonnet S, Tremblay E, Biardel S, Racine C, Courture C, Bonnet P, Majka SM, Deshaies Y, Picard F, Provencher S, Bonnet S", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": 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Monteith GR", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23686305", "url": "https://glygen.org/publication/PubMed/23686305" } ] }, { "title": "Inhibition of glycogen synthase kinase-3 increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of STAT3.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2013", "authors": "Fionda C, Malgarini G, Soriani A, Zingoni A, Cecere F, Iannitto ML, Ricciardi MR, Federico V, Petrucci MT, Santoni A, Cippitelli M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23686482", "url": "https://glygen.org/publication/PubMed/23686482" } ] }, { "title": "Simvastatin inhibits renal cancer cell growth and metastasis via AKT/mTOR, ERK and JAK2/STAT3 pathway.", "journal": "PloS one", "date": "2013", "authors": "Fang Z, Tang Y, Fang J, Zhou Z, Xing Z, Guo Z, Guo X, Wang W, Jiao W, Xu Z, Liu Z", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23690956", "url": "https://glygen.org/publication/PubMed/23690956" } ] }, { "title": "Brevilin A, a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells.", "journal": "PloS one", "date": "2013", "authors": "Chen X, Du Y, Nan J, Zhang X, Qin X, Wang Y, Hou J, Wang Q, Yang J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23704931", "url": "https://glygen.org/publication/PubMed/23704931" } ] }, { "title": "Cryptotanshinone inhibits human glioma cell proliferation by suppressing STAT3 signaling.", "journal": "Molecular and cellular biochemistry", "date": "2013", "authors": "Lu L, Li C, Li D, Wang Y, Zhou C, Shao W, Peng J, You Y, Zhang X, Shen X", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23740516", "url": "https://glygen.org/publication/PubMed/23740516" } ] }, { "title": "An age-related numerical and functional deficit in CD19(+) CD24(hi) CD38(hi) B cells is associated with an increase in systemic autoimmunity.", "journal": "Aging cell", "date": "2013", "authors": "Duggal NA, Upton J, Phillips AC, Sapey E, Lord JM", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23755918", "url": "https://glygen.org/publication/PubMed/23755918" } ] }, { "title": "Inhibition of VEGF expression through blockade of Hif1alpha and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells.", "journal": "British journal of cancer", "date": "2013", "authors": "Carbajo-Pescador S, Ordonez R, Benet M, Jover R, Garcia-Palomo A, Mauriz JL, Gonzalez-Gallego J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23756865", "url": "https://glygen.org/publication/PubMed/23756865" } ] }, { "title": "Deficiency of Erbin induces resistance of cervical cancer cells to anoikis in a STAT3-dependent manner.", "journal": "Oncogenesis", "date": "2013", "authors": "Hu Y, Chen H, Duan C, Liu D, Qian L, Yang Z, Guo L, Song L, Yu M, Hu M, Shi M, Guo N", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23774064", "url": "https://glygen.org/publication/PubMed/23774064" } ] }, { "title": "5,8-Dimethoxy-2-Nonylamino-Naphthalene-1,4-Dione Inhibits Vascular Smooth Muscle Cell Proliferation by Blocking Autophosphorylation of PDGF-Receptor beta.", "journal": "The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology", "date": "2013", "authors": "Kim Y, Lee JJ, Lee SG, Jung SH, Han JH, Yang SY, Yun E, Song GY, Myung CS", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23776396", "url": "https://glygen.org/publication/PubMed/23776396" } ] }, { "title": "Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells.", "journal": "The Biochemical journal", "date": "2013", "authors": "Wiejak J, Dunlop J, Mackay SP, Yarwood SJ", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23782265", "url": "https://glygen.org/publication/PubMed/23782265" } ] }, { "title": "STAT3 integrates cytokine and neurotrophin signals to promote sympathetic axon regeneration.", "journal": "Molecular and cellular neurosciences", "date": "2013", "authors": "Pellegrino MJ, Habecker BA", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23831387", "url": "https://glygen.org/publication/PubMed/23831387" } ] }, { "title": "A novel missense (M206K) STAT3 mutation in diffuse large B cell lymphoma deregulates STAT3 signaling.", "journal": "PloS one", "date": "2013", "authors": "Hu G, Witzig TE, Gupta M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": 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overcomes acquired resistance to erlotinib through suppression of STAT3 in non-small cell lung cancer.", "journal": "Molecular cancer therapeutics", "date": "2013", "authors": "Li R, Hu Z, Sun SY, Chen ZG, Owonikoko TK, Sica GL, Ramalingam SS, Curran WJ, Khuri FR, Deng X", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23894143", "url": "https://glygen.org/publication/PubMed/23894143" } ] }, { "title": "Human cytomegalovirus IE1 protein disrupts interleukin-6 signaling by sequestering STAT3 in the nucleus.", "journal": "Journal of virology", "date": "2013", "authors": "Reitsma JM, Sato H, Nevels M, Terhune SS, Paulus C", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23903834", "url": "https://glygen.org/publication/PubMed/23903834" } ] }, { "title": "Tyrosine 416 is phosphorylated in the closed, repressed conformation of c-Src.", "journal": "PloS one", "date": "2013", "authors": "Irtegun S, Wood RJ, Ormsby AR, Mulhern TD, Hatters DM", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23923048", "url": "https://glygen.org/publication/PubMed/23923048" } ] }, { "title": "Early methyl donor deficiency may induce persistent brain defects by reducing Stat3 signaling targeted by miR-124.", "journal": "Cell death & disease", "date": "2013", "authors": "Kerek R, Geoffroy A, Bison A, Martin N, Akchiche N, Pourie G, Helle D, Gueant JL, Bossenmeyer-Pourie C, Daval JL", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23928694", "url": "https://glygen.org/publication/PubMed/23928694" } ] }, { "title": "STAT3 activation promotes oncolytic HSV1 replication in glioma cells.", "journal": "PloS one", "date": "2013", "authors": "Okemoto K, Wagner B, Meisen H, Haseley A, Kaur B, Chiocca EA", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23936533", "url": "https://glygen.org/publication/PubMed/23936533" } ] }, { "title": "Activation state-dependent interaction between Galphaq subunits and the Fhit tumor suppressor.", "journal": "Cell communication and signaling : CCS", "date": "2013", "authors": "Zuo H, Chan GP, Zhu J, Yeung WW, Chan AS, Ammer H, Wong YH", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23947369", "url": "https://glygen.org/publication/PubMed/23947369" } ] }, { "title": "STAT3 regulates MMP3 in heme-induced endothelial cell apoptosis.", "journal": "PloS one", "date": "2013", "authors": "Liu M, Wilson NO, Hibbert JM, Stiles JK", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" }, { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23967200", "url": "https://glygen.org/publication/PubMed/23967200" } ] }, { "title": "STAT3 or USF2 contributes to HIF target gene specificity.", "journal": "PloS one", "date": "2013", "authors": "Pawlus MR, Wang L, Murakami A, Dai G, Hu CJ", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23991099", "url": "https://glygen.org/publication/PubMed/23991099" } ] }, { "title": "Protein kinase C zeta regulates human pancreatic cancer cell transformed growth and invasion through a STAT3-dependent mechanism.", "journal": "PloS one", "date": "2013", "authors": "Butler AM, Scotti Buzhardt ML, Li S, Smith KE, Fields AP, Murray NR", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24015205", "url": "https://glygen.org/publication/PubMed/24015205" } ] }, { "title": "Inhibition of STAT3 by niclosamide synergizes with erlotinib against head and neck cancer.", "journal": "PloS one", "date": "2013", "authors": "Li R, You S, Hu Z, Chen ZG, Sica GL, Khuri FR, Curran WJ, Shin DM, Deng X", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24019973", "url": "https://glygen.org/publication/PubMed/24019973" } ] }, { "title": "ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells.", "journal": "The Journal of experimental medicine", "date": "2013", "authors": "Niederreiter L, Fritz TM, Adolph TE, Krismer AM, Offner FA, Tschurtschenthaler M, Flak MB, Hosomi S, Tomczak MF, Kaneider NC, Sarcevic E, Kempster SL, Raine T, Esser D, Rosenstiel P, Kohno K, Iwawaki T, Tilg H, Blumberg RS, Kaser A", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24043762", "url": "https://glygen.org/publication/PubMed/24043762" } ] }, { "title": "Additive effect on survival of Raf kinase inhibitor protein and signal transducer and activator of transcription 3 in high-grade glioma.", "journal": "Cancer", "date": "2011", "authors": "Maresch J, Birner P, Zakharinov M, Toumangelova-Uzeir K, Natchev S, Guentchev M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24048798", "url": "https://glygen.org/publication/PubMed/24048798" } ] }, { "title": "Modulation of human JAK-STAT pathway signaling by functionally conserved regulators.", "journal": "JAK-STAT", "date": "2012", "authors": "Muller P, Pugazhendhi D, Zeidler MP", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24058749", "url": "https://glygen.org/publication/PubMed/24058749" } ] }, { "title": "The consequences of selective inhibition of signal transducer and activator of transcription 3 (STAT3) tyrosine705 phosphorylation by phosphopeptide mimetic prodrugs targeting the Src homology 2 (SH2) domain.", "journal": "JAK-STAT", "date": "2012", "authors": "McMurray JS, Mandal PK, Liao WS, Klostergaard J, Robertson FM", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24058783", "url": "https://glygen.org/publication/PubMed/24058783" } ] }, { "title": "STAT3 regulation by S-nitrosylation: implication for inflammatory disease.", "journal": "Antioxidants & redox signaling", "date": "2014", "authors": "Kim J, Won JS, Singh AK, Sharma AK, Singh I", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24063605", "url": "https://glygen.org/publication/PubMed/24063605" } ] }, { "title": "The cardioprotective effects of urocortin are mediated via activation of the Src tyrosine kinase-STAT3 pathway.", "journal": "JAK-STAT", "date": "2013", "authors": "Chen-Scarabelli C, Saravolatz Ii L, McCaukey R, Scarabelli G, Di Rezze J, Mohanty B, Barry S, Latchman D, Georgiadis V, McCormick J, Saravolatz L, Knight R, Faggian G, Narula J, Stephanou A, Scarabelli TM", "evidence": [ { "database": "iPTMnet", "id": 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"P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24129709", "url": "https://glygen.org/publication/PubMed/24129709" } ] }, { "title": "\u0394Np63 promotes pediatric neuroblastoma and osteosarcoma by regulating tumor angiogenesis.", "journal": "Cancer research", "date": "2014-01-01", "authors": "Bid Hemant K, Roberts Ryan D, Cam Maren, Audino Anthony, Kurmasheva Raushan T, Lin Jiayuh, Houghton Peter J, Cam Hakan", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24154873", "url": "https://glygen.org/publication/PubMed/24154873" } ] }, { "title": "Phosphorylation of STAT3 correlates with HER2 status, but not with survival in pancreatic ductal adenocarcinoma.", "journal": "APMIS : acta pathologica, microbiologica, et immunologica Scandinavica", "date": "2014", "authors": "Koperek O, Aumayr K, Schindl M, Werba G, Soleiman A, Schoppmann S, Sahora K, Birner P", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24164699", "url": "https://glygen.org/publication/PubMed/24164699" } ] }, { "title": "12/15-lipoxygenase contributes to platelet-derived growth factor-induced activation of signal transducer and activator of transcription 3.", "journal": "The Journal of biological chemistry", "date": "2013", "authors": "Blazevic T, Schwaiberger AV, Schreiner CE, Schachner D, Schaible AM, Grojer CS, Atanasov AG, Werz O, Dirsch VM, Heiss EH", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24165129", "url": "https://glygen.org/publication/PubMed/24165129" } ] }, { "title": "Dominant-negative activity of the STAT3-Y705F mutant depends on the N-terminal domain.", "journal": "Cell communication and signaling : CCS", "date": "2013", "authors": "Mohr A, Fahrenkamp D, Rinis N, Muller-Newen G", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24192293", "url": "https://glygen.org/publication/PubMed/24192293" } ] }, { "title": "Gefitinib resistance resulted from STAT3-mediated Akt activation in lung cancer cells.", "journal": "Oncotarget", "date": "2013", "authors": "Wu K, Chang Q, Lu Y, Qiu P, Chen B, Thakur C, Sun J, Li L, Kowluru A, Chen F", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24280348", "url": "https://glygen.org/publication/PubMed/24280348" } ] }, { "title": "Intranuclear crosstalk between extracellular regulated kinase1/2 and signal transducer and activator of transcription 3 regulates JEG-3 choriocarcinoma cell invasion and proliferation.", "journal": "TheScientificWorldJournal", "date": "2013", "authors": "Morales-Prieto DM, Ospina-Prieto S, Chaiwangyen W, Weber M, Holters S, Schleussner E, Fitzgerald JS, Markert UR", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24288470", "url": "https://glygen.org/publication/PubMed/24288470" } ] }, { "title": "The MEK-ERK pathway is necessary for serine phosphorylation of mitochondrial STAT3 and Ras-mediated transformation.", "journal": "PloS one", "date": "2013", "authors": "Gough DJ, Koetz L, Levy DE", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24312439", "url": "https://glygen.org/publication/PubMed/24312439" } ] }, { "title": "[Overexpression of 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W, Deng X, Zhang J, Yu H, He G", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24324713", "url": "https://glygen.org/publication/PubMed/24324713" } ] }, { "title": "Knockdown of astrocyte elevated gene-1 inhibits growth through suppression of IL-6 secretion in HepG2 human hepatoma cells.", "journal": "Oncology letters", "date": "2014", "authors": "Deng H, Zhou Z, Tu W, Xia Y, Huang H, Tian D", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24348829", "url": "https://glygen.org/publication/PubMed/24348829" } ] }, { "title": "YC-1 enhances the anti-tumor activity of sorafenib through inhibition of signal transducer and activator of transcription 3 (STAT3) in hepatocellular carcinoma.", "journal": "Molecular cancer", "date": "2014", "authors": "Kong J, Kong F, Gao J, Zhang Q, Dong S, Gu F, Ke S, Pan B, Shen Q, Sun H, Zheng L, Sun W", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24418169", "url": "https://glygen.org/publication/PubMed/24418169" } ] }, { "title": "Everolimus-induced human keratinocytes toxicity is mediated by STAT3 inhibition.", "journal": "Journal of experimental & clinical cancer research : CR", "date": "2013", "authors": "Yamamoto K, Uda A, Mukai A, Yamashita K, Kume M, Makimoto H, Bito T, Nishigori C, Hirano T, Hirai M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24423131", "url": "https://glygen.org/publication/PubMed/24423131" } ] }, { "title": "Epstein-Barr Virus encoded LMP1 regulates cyclin D1 promoter activity by nuclear EGFR and STAT3 in CNE1 cells.", "journal": "Journal of experimental & clinical cancer research : CR", "date": "2013", "authors": "Xu Y, Shi Y, Yuan Q, Liu X, Yan B, Chen L, Tao Y, Cao Y", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24499623", "url": "https://glygen.org/publication/PubMed/24499623" } ] }, { "title": "Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent manner.", "journal": "PloS one", "date": "2014", "authors": "Guo J, Wu G, Bao J, Hao W, Lu J, Chen X", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24505404", "url": "https://glygen.org/publication/PubMed/24505404" } ] }, { "title": "Effects of AG490 and S3I-201 on regulation of the JAK/STAT3 signaling pathway in relation to angiogenesis in TRAIL-resistant prostate cancer cells in vitro.", "journal": "Oncology letters", "date": "2014", "authors": "Gurbuz V, Konac E, Varol N, Yilmaz A, Gurocak S, Menevse S, Sozen S", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24520293", "url": "https://glygen.org/publication/PubMed/24520293" } ] }, { "title": "RhoC regulates cancer stem cells in head and neck squamous cell carcinoma by overexpressing IL-6 and phosphorylation of STAT3.", "journal": "PloS one", "date": "2014", "authors": "Islam M, Sharma S, Teknos TN", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24533098", "url": "https://glygen.org/publication/PubMed/24533098" } ] }, { "title": "Honokiol enhances paclitaxel efficacy in multi-drug resistant human cancer model through the induction of apoptosis.", "journal": "PloS one", "date": "2014", "authors": "Wang X, Beitler JJ, Wang H, Lee MJ, Huang W, Koenig L, Nannapaneni S, Amin AR, Bonner M, Shin HJ, Chen ZG, Arbiser JL, Shin DM", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24586249", "url": "https://glygen.org/publication/PubMed/24586249" } ] }, { "title": "Type-1 interferons contribute to oxygen glucose deprivation induced neuro-inflammation in BE(2)M17 human neuroblastoma cells.", "journal": "Journal of neuroinflammation", "date": "2014", "authors": "Minter MR, Zhang M, Ates RC, Taylor JM, Crack PJ", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24602263", "url": "https://glygen.org/publication/PubMed/24602263" } ] }, { "title": "Signal integration and gene 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Serra V, Nijman SM", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "25699542", "url": "https://glygen.org/publication/PubMed/25699542" } ] }, { "title": "Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis.", "journal": "Nature communications", "date": "2015", "authors": "Grabner B, Schramek D, Mueller KM, Moll HP, Svinka J, Hoffmann T, Bauer E, Blaas L, Hruschka N, Zboray K, Stiedl P, Nivarthi H, Bogner E, Gruber W, Mohr T, Zwick RH, Kenner L, Poli V, Aberger F, Stoiber D, Egger G, Esterbauer H, Zuber J, Moriggl R, Eferl R, Gyorffy B, Penninger JM, Popper H, Casanova E", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "25734337", "url": "https://glygen.org/publication/PubMed/25734337" } ] }, { "title": "STAT3 Serine 727 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Xie Y, Ye T, Wei Y", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "25811798", "url": "https://glygen.org/publication/PubMed/25811798" } ] }, { "title": "Janus kinase 2/signal transducer and activator of transcription 3 inhibitors attenuate the effect of cardiotrophin-like cytokine factor 1 and human focal segmental glomerulosclerosis serum on glomerular filtration barrier.", "journal": "Translational research : the journal of laboratory and clinical medicine", "date": "2015", "authors": "Sharma M, Zhou J, Gauchat JF, Sharma R, McCarthy ET, Srivastava T, Savin VJ", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "25843671", "url": "https://glygen.org/publication/PubMed/25843671" } ] }, { "title": "\u03b4-tocotrienol induces human bladder 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the responsiveness to SR141716 treatment in human glioma patients' cells.", "journal": "Oncotarget", "date": "2015", "authors": "Ciaglia E, Torelli G, Pisanti S, Picardi P, D'Alessandro A, Laezza C, Malfitano AM, Fiore D, Pagano Zottola AC, Proto MC, Catapano G, Gazzerro P, Bifulco M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "26008966", "url": "https://glygen.org/publication/PubMed/26008966" } ] }, { "title": "Induction of miRNA-181a by genotoxic treatments promotes chemotherapeutic resistance and metastasis in breast cancer.", "journal": "Oncogene", "date": "2016", "authors": "Niu J, Xue A, Chi Y, Xue J, Wang W, Zhao Z, Fan M, Yang CH, Shao ZM, Pfeffer LM, Wu J, Wu ZH", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "26028030", "url": 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Gastrointestinal and liver physiology", "date": "2015", "authors": "Yu C, Huo X, Agoston AT, Zhang X, Theiss AL, Cheng E, Zhang Q, Zaika A, Pham TH, Wang DH, Lobie PE, Odze RD, Spechler SJ, Souza RF", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "26045618", "url": "https://glygen.org/publication/PubMed/26045618" } ] }, { "title": "Alterations in microRNAs miR-21 and let-7a correlate with aberrant STAT3 signaling and downstream effects during cervical carcinogenesis.", "journal": "Molecular cancer", "date": "2015", "authors": "Shishodia G, Shukla S, Srivastava Y, Masaldan S, Mehta S, Bhambhani S, Sharma S, Mehrotra R, Das BC, Bharti AC", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "26051842", "url": 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Advanced Primary Liver Cancer.", "journal": "Neoplasia (New York, N.Y.)", "date": "2016", "authors": "Rojas A, Zhang P, Wang Y, Foo WC, Munoz NM, Xiao L, Wang J, Gores GJ, Hung MC, Blechacz B", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "27292026", "url": "https://glygen.org/publication/PubMed/27292026" } ] }, { "title": "Deregulation of SOCS5 suppresses dendritic cell function in chronic lymphocytic leukemia.", "journal": "Oncotarget", "date": "2016", "authors": "Toniolo PA, Liu S, Yeh JE, Ye DQ, Barbuto JA, Frank DA", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "27317770", "url": "https://glygen.org/publication/PubMed/27317770" } ] }, { "title": "Iciartin, a novel FASN inhibitor, exerts anti-melanoma activities through IGF-1R/STAT3 signaling.", "journal": "Oncotarget", "date": "2016", "authors": "Wu J, Du J, Fu X, Liu B, Cao H, Li T, Su T, Xu J, Tse AK, Yu ZL", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "27323414", "url": "https://glygen.org/publication/PubMed/27323414" } ] }, { "title": "Proteasome Inhibitor YSY01A Enhances Cisplatin Cytotoxicity in Cisplatin-Resistant Human Ovarian Cancer Cells.", "journal": "Journal of Cancer", "date": "2016", "authors": "Huang W, Zhou Q, Yuan X, Ge ZM, Ran FX, Yang HY, Qiang GL, Li RT, Cui JR", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "27326257", "url": "https://glygen.org/publication/PubMed/27326257" } ] }, { "title": "PDGFRalpha depletion attenuates glioblastoma stem cells features by modulation of STAT3, RB1 and multiple oncogenic signals.", "journal": "Oncotarget", "date": "2016", "authors": "Cenciarelli C, Marei HE, Felsani A, Casalbore P, Sica G, Puglisi MA, Cameron AJ, Olivi A, Mangiola A", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "27344175", "url": "https://glygen.org/publication/PubMed/27344175" } ] }, { "title": "MDM2 facilitates adipocyte differentiation through CRTC-mediated activation of STAT3.", "journal": "Cell death & disease", "date": "2016", "authors": "Hallenborg P, Siersbaek M, Barrio-Hernandez I, Nielsen R, Kristiansen K, Mandrup S, Grontved L, Blagoev B", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "27362806", "url": "https://glygen.org/publication/PubMed/27362806" } ] }, { "title": "Down-Regulation of SOX2 Underlies the Inhibitory Effects of the Triphenylmethane Gentian Violet on Melanoma Cell Self-Renewal and Survival.", "journal": "The Journal of investigative dermatology", "date": "2016", "authors": "Pietrobono S, Morandi A, Gagliardi S, Gerlini G, Borgognoni L, Chiarugi P, Arbiser JL, Stecca B", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "27373978", "url": "https://glygen.org/publication/PubMed/27373978" } ] }, { "title": "STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection.", "journal": "Scientific reports", "date": "2016", "authors": "Queval CJ, Song OR, Deboosere N, Delorme V, Debrie AS, Iantomasi R, Veyron-Churlet R, Jouny S, Redhage K, Deloison G, Baulard A, Chamaillard M, Locht C, Brodin P", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } 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journal", "date": "2016", "authors": "Butturini E, Gotte G, Dell'Orco D, Chiavegato G, Marino V, Canetti D, Cozzolino F, Monti M, Pucci P, Mariotto S", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "27486258", "url": "https://glygen.org/publication/PubMed/27486258" } ] }, { "title": "Cell-based phenotypic screening of mast cell degranulation unveils kinetic perturbations of agents targeting phosphorylation.", "journal": "Scientific reports", "date": "2016", "authors": "Qin S, Wang X, Wu H, Xiao P, Cheng H, Zhang X, Ke Y", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "27502076", "url": "https://glygen.org/publication/PubMed/27502076" } ] }, { "title": "Gp130-mediated STAT3 activation by S-propargyl-cysteine, an endogenous hydrogen sulfide 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"Rig-G is a growth inhibitory factor of lung cancer cells that suppresses STAT3 and NF-kappaB.", "journal": "Oncotarget", "date": "2016", "authors": "Li D, Sun J, Liu W, Wang X, Bals R, Wu J, Quan W, Yao Y, Zhang Y, Zhou H, Wu K", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "27602766", "url": "https://glygen.org/publication/PubMed/27602766" } ] }, { "title": "ITF promotes migration of intestinal epithelial cells through crosstalk between the ERK and JAK/STAT3 pathways.", "journal": "Scientific reports", "date": "2016", "authors": "Le J, Zhang DY, Zhao Y, Qiu W, Wang P, Sun Y", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "27616044", "url": "https://glygen.org/publication/PubMed/27616044" } ] }, { "title": "Alternol, a natural compound, exerts an anti-tumour effect on osteosarcoma by modulating of STAT3 and ROS/MAPK signalling pathways.", "journal": "Journal of cellular and molecular medicine", "date": "2017", "authors": "Zuo D, Zhou Z, Wang H, Zhang T, Zang J, Yin F, Sun W, Chen J, Duan L, Xu J, Wang Z, Wang C, Lin B, Fu Z, Liao Y, Li S, Sun M, Hua Y, Zheng L, Cai Z", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "27624867", "url": "https://glygen.org/publication/PubMed/27624867" } ] }, { "title": "Fyn phosphorylates AMPK to inhibit AMPK activity and AMP-dependent activation of autophagy.", "journal": "Oncotarget", "date": "2016", "authors": "Yamada E, Okada S, Bastie CC, Vatish M, Nakajima Y, Shibusawa R, Ozawa A, Pessin JE, Yamada M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": 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"id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "27708408", "url": "https://glygen.org/publication/PubMed/27708408" } ] }, { "title": "The ETS factor ESE3/EHF represses IL-6 preventing STAT3 activation and expansion of the prostate cancer stem-like compartment.", "journal": "Oncotarget", "date": "2016", "authors": "Albino D, Civenni G, Rossi S, Mitra A, Catapano CV, Carbone GM", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "27732936", "url": "https://glygen.org/publication/PubMed/27732936" } ] }, { "title": "Glutamine activates STAT3 to control cancer cell proliferation independently of glutamine metabolism.", "journal": "Oncogene", "date": "2017", "authors": "Cacace A, Sboarina M, Vazeille T, Sonveaux P", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": 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Zhang M, Zhang X", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "27834930", "url": "https://glygen.org/publication/PubMed/27834930" } ] }, { "title": "Platelet derived growth factor receptor alpha mediates nodal metastases in papillary thyroid cancer by driving the epithelial-mesenchymal transition.", "journal": "Oncotarget", "date": "2016", "authors": "Ekpe-Adewuyi E, Lopez-Campistrous A, Tang X, Brindley DN, McMullen TP", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "27845909", "url": "https://glygen.org/publication/PubMed/27845909" } ] }, { "title": "Genomic and Transcriptomic Alterations Associated with STAT3 Activation in Head and Neck Cancer.", "journal": "PloS one", "date": "2016", "authors": "Peyser ND, Pendleton K, Gooding WE, Lui VW, Johnson DE, Grandis JR", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "27855189", "url": "https://glygen.org/publication/PubMed/27855189" } ] }, { "title": "Expression of Par3 polarity protein correlates with poor prognosis in ovarian cancer.", "journal": "BMC cancer", "date": "2016", "authors": "Nakamura H, Nagasaka K, Kawana K, Taguchi A, Uehara Y, Yoshida M, Sato M, Nishida H, Fujimoto A, Inoue T, Adachi K, Nagamatsu T, Arimoto T, Oda K, Osuga Y, Fujii T", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "27855669", "url": "https://glygen.org/publication/PubMed/27855669" } ] }, { "title": "Arctigenin inhibits STAT3 and exhibits anticancer potential in human triple-negative breast cancer therapy.", "journal": "Oncotarget", "date": "2017", "authors": "Feng T, Cao W, Shen W, Zhang L, Gu X, Guo Y, Tsai HI, Liu X, Li J, Zhang J, Li S, Wu F, Liu Y", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "27861147", "url": "https://glygen.org/publication/PubMed/27861147" } ] }, { "title": "The antiviral cytokine interferon-gamma restricts neural stem/progenitor cell proliferation through activation of STAT1 and modulation of retinoblastoma protein phosphorylation.", "journal": "Journal of neuroscience research", "date": "2017", "authors": "Kulkarni A, Scully TJ, O'Donnell LA", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "27862183", "url": "https://glygen.org/publication/PubMed/27862183" } ] }, { "title": "The mechanism of CIRP in inhibition of keratinocytes growth arrest and apoptosis following low dose UVB radiation.", "journal": "Molecular carcinogenesis", "date": "2017", "authors": "Liao Y, Feng J, Zhang Y, Tang L, Wu S", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "27864909", "url": "https://glygen.org/publication/PubMed/27864909" } ] }, { "title": "STAT3 Potentiates SIAH-1 Mediated Proteasomal Degradation of beta-Catenin in Human Embryonic Kidney Cells.", "journal": "Molecules and cells", "date": "2016", "authors": "Shin M, Yi EH, Kim BH, Shin JC, Park JY, Cho CH, Park JW, Choi KY, Ye SK", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "27871173", "url": "https://glygen.org/publication/PubMed/27871173" } ] }, { "title": "Niclosamide and its analogs are potent inhibitors of Wnt/beta-catenin, mTOR and STAT3 signaling in ovarian cancer.", "journal": "Oncotarget", "date": "2016", "authors": "Arend RC, Londono-Joshi AI, Gangrade A, Katre AA, Kurpad C, Li Y, Samant RS, Li PK, Landen CN, Yang ES, Hidalgo B, Alvarez RD, Straughn JM, Forero A, Buchsbaum DJ", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "27888804", "url": "https://glygen.org/publication/PubMed/27888804" } ] }, { "title": "Novel Src/Abl tyrosine kinase inhibitor bosutinib suppresses neuroblastoma growth via inhibiting Src/Abl signaling.", "journal": "Oncotarget", "date": "2017", "authors": "Bieerkehazhi S, Chen Z, Zhao Y, Yu Y, Zhang H, Vasudevan SA, Woodfield SE, Tao L, Yi JS, Muscal JA, Pang JC, Guan S, Zhang H, Nuchtern JG, Li H, Li H, Yang J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "27903968", "url": "https://glygen.org/publication/PubMed/27903968" } ] }, { "title": "Downregulated expression of microRNA-124 in pediatric intestinal failure patients modulates macrophages activation by inhibiting STAT3 and AChE.", "journal": "Cell death & disease", "date": "2016", "authors": "Xiao YT, Wang J, Lu W, Cao Y, Cai W", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "27977009", "url": "https://glygen.org/publication/PubMed/27977009" } ] }, { "title": "A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis.", "journal": "Nature communications", "date": "2016", "authors": "Jeric I, Maurer G, Cavallo AL, Raguz J, Desideri E, Tarkowski B, Parrini M, Fischer I, Zatloukal K, Baccarini M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "28000790", "url": "https://glygen.org/publication/PubMed/28000790" } ] }, { "title": "STAT3 Undergoes Acetylation-dependent Mitochondrial Translocation to Regulate Pyruvate Metabolism.", "journal": "Scientific reports", "date": "2016", "authors": "Xu YS, Liang JJ, Wang Y, Zhao XJ, Xu L, Xu YY, Zou QC, Zhang JM, Tu CE, Cui YG, Sun WH, Huang C, Yang JH, Chin YE", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "28004755", "url": "https://glygen.org/publication/PubMed/28004755" } ] }, { "title": "Hippocalcin Promotes Neuronal Differentiation and Inhibits Astrocytic Differentiation in Neural Stem Cells.", "journal": "Stem cell reports", "date": "2017", "authors": "Park SY, Yoon SN, Kang MJ, Lee Y, Jung SJ, Han JS", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "28017654", "url": "https://glygen.org/publication/PubMed/28017654" } ] }, { "title": "Stattic and metformin inhibit brain tumor initiating cells by reducing STAT3-phosphorylation.", "journal": "Oncotarget", "date": "2017", "authors": "Leidgens V, Proske J, Rauer L, Moeckel S, Renner K, Bogdahn U, Riemenschneider MJ, Proescholdt M, Vollmann-Zwerenz A, Hau P, Seliger C", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "28030813", "url": "https://glygen.org/publication/PubMed/28030813" } ] }, { "title": "WP1066 suppresses macrophage cell death induced by inflammasome agonists independently of its inhibitory effect on STAT3.", "journal": "Cancer science", "date": "2017", "authors": "Honda S, Sadatomi D, Yamamura Y, Nakashioya K, Tanimura S, Takeda K", 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T, Kudo Y, Iizuka S, Tsunematsu T, Umehara H, Shrestha M, Matsuo T, Kubo T, Shimose S, Arihiro K, Ogawa I, Ochi M, Takata T", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "28054649", "url": "https://glygen.org/publication/PubMed/28054649" } ] }, { "title": "Inhibition of Stat3 signaling pathway by nifuroxazide improves antitumor immunity and impairs colorectal carcinoma metastasis.", "journal": "Cell death & disease", "date": "2017", "authors": "Ye TH, Yang FF, Zhu YX, Li YL, Lei Q, Song XJ, Xia Y, Xiong Y, Zhang LD, Wang NY, Zhao LF, Gou HF, Xie YM, Yang SY, Yu LT, Yang L, Wei YQ", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "28055016", "url": "https://glygen.org/publication/PubMed/28055016" } ] }, { "title": "TRIM8 regulates stemness in glioblastoma through PIAS3-STAT3.", "journal": "Molecular oncology", "date": "2017", "authors": "Zhang C, Mukherjee S, Tucker-Burden C, Ross JL, Chau MJ, Kong J, Brat DJ", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "28100038", "url": "https://glygen.org/publication/PubMed/28100038" } ] }, { "title": "The Novel PIM1 Inhibitor NMS-P645 Reverses PIM1-Dependent Effects on TMPRSS2/ERG Positive Prostate Cancer Cells And Shows Anti-Proliferative Activity in Combination with PI3K Inhibition.", "journal": "Journal of Cancer", "date": "2017", "authors": "Mologni L, Magistroni V, Casuscelli F, Montemartini M, Gambacorti-Passerini C", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "28123608", "url": "https://glygen.org/publication/PubMed/28123608" } ] }, { "title": "Inhibition of STAT3 by Anticancer Drug Bendamustine.", "journal": "PloS one", "date": "2017", "authors": "Iwamoto K, Uehara Y, Inoue Y, Taguchi K, Muraoka D, Ogo N, Matsuno K, Asai A", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "28125678", "url": "https://glygen.org/publication/PubMed/28125678" } ] }, { "title": "THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors.", "journal": "Nature communications", "date": "2017", "authors": "Cayrol F, Praditsuktavorn P, Fernando TM, Kwiatkowski N, Marullo R, Calvo-Vidal MN, Phillip J, Pera B, Yang SN, Takpradit K, Roman L, Gaudiano M, Crescenzo R, Ruan J, Inghirami G, Zhang T, Cremaschi G, Gray NS, Cerchietti L", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "28134252", "url": "https://glygen.org/publication/PubMed/28134252" } ] }, { "title": "Suppression of the Growth and Invasion of Human Head and Neck Squamous Cell Carcinomas via Regulating STAT3 Signaling and the miR-21/beta-catenin Axis with HJC0152.", "journal": "Molecular cancer therapeutics", "date": "2017", "authors": "Wang Y, Wang S, Wu Y, Ren Y, Li Z, Yao X, Zhang C, Ye N, Jing C, Dong J, Zhang K, Sun S, Zhao M, Guo W, Qu X, Qiao Y, Chen H, Kong L, Jin R, Wang X, Zhang L, Zhou J, Shen Q, Zhou X", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "28138036", "url": "https://glygen.org/publication/PubMed/28138036" } ] }, { "title": "Dimethyl Fumarate ameliorates pulmonary arterial hypertension and lung fibrosis by targeting multiple pathways.", "journal": "Scientific reports", "date": "2017", "authors": "Grzegorzewska AP, Seta F, Han R, Czajka CA, Makino K, Stawski L, Isenberg JS, Browning JL, Trojanowska M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "28150703", "url": "https://glygen.org/publication/PubMed/28150703" } ] }, { "title": "Wogonin reversed resistant human myelogenous leukemia cells via inhibiting Nrf2 signaling by Stat3/NF-kappaB inactivation.", "journal": "Scientific reports", "date": "2017", "authors": "Xu X, Zhang X, Zhang Y, Yang L, Liu Y, Huang S, Lu L, Kong L, Li Z, Guo Q, Zhao L", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "28150717", "url": "https://glygen.org/publication/PubMed/28150717" } ] }, { "title": "EpEX/EpCAM and Oct4 or Klf4 alone are sufficient to generate induced pluripotent stem cells through STAT3 and HIF2alpha.", "journal": "Scientific reports", "date": "2017", "authors": "Kuan II, Liang KH, Wang YP, Kuo TW, Meir YJ, Wu SC, Yang SC, Lu J, Wu HC", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "28157205", "url": "https://glygen.org/publication/PubMed/28157205" } ] }, { "title": "Anti-cancer effect of danshen and dihydroisotanshinone I on prostate cancer: targeting the crosstalk between macrophages and cancer cells via inhibition of the STAT3/CCL2 signaling pathway.", "journal": "Oncotarget", "date": "2017", "authors": "Wu CY, Yang YH, Lin YY, Kuan FC, Lin YS, Lin WY, Tsai MY, Yang JJ, Cheng YC, Shu LH, Lu MC, Chen YJ, Lee KD, Kang HY", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "28157698", "url": "https://glygen.org/publication/PubMed/28157698" } ] }, { "title": "The interference of Notch1 target Hes1 affects cell growth, differentiation and invasiveness of glioblastoma stem cells through modulation of multiple oncogenic targets.", "journal": "Oncotarget", "date": "2017", "authors": "Cenciarelli C, Marei HE, Zonfrillo M, Casalbore P, Felsani A, Giannetti S, Trevisi G, Althani A, Mangiola A", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "28157712", "url": "https://glygen.org/publication/PubMed/28157712" } ] }, { "title": "miRNA-1246 induces pro-inflammatory responses in mesenchymal stem/stromal cells by regulating PKA and PP2A.", "journal": "Oncotarget", "date": "2017", "authors": "Bott A, Erdem N, Lerrer S, Hotz-Wagenblatt A, Breunig C, Abnaof K, Worner A, Wilhelm H, Munstermann E, Ben-Baruch A, Wiemann S", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "28159925", "url": "https://glygen.org/publication/PubMed/28159925" } ] }, { "title": "Curcumin decreases malignant characteristics of glioblastoma stem cells via induction of reactive oxygen species.", "journal": "BMC cancer", "date": "2017", "authors": "Gersey ZC, Rodriguez GA, Barbarite E, Sanchez A, Walters WM, Ohaeto KC, Komotar RJ, Graham RM", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "28160777", "url": "https://glygen.org/publication/PubMed/28160777" } ] }, { "title": "Nardilysin promotes hepatocellular carcinoma through activation of signal transducer and activator of transcription 3.", "journal": "Cancer science", "date": "2017", "authors": "Kasai Y, Toriguchi K, Hatano E, Nishi K, Ohno M, Yoh T, Fukuyama K, Nishio T, Okuno M, Iwaisako K, Seo S, Taura K, Kurokawa M, Kunichika M, Uemoto S, Nishi E", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "28207963", "url": "https://glygen.org/publication/PubMed/28207963" } ] }, { "title": "Cryptotanshinone potentiates the antitumor effects of doxorubicin on gastric cancer cells via inhibition of STAT3 activity.", "journal": "The Journal of international medical research", "date": "2017-02", "authors": "Wang Jiye, Zhang Guangji, Dai Chunyan, Gao Xiufei, Wu Jianbin, Shen Li, Chen Zhe, Liu Pei", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "28222632", "url": "https://glygen.org/publication/PubMed/28222632" } ] }, { "title": "Role of STAT3 and FOXO1 in the Divergent Therapeutic Responses of Non-metastatic and Metastatic Bladder Cancer Cells to miR-145.", "journal": "Molecular cancer therapeutics", "date": "2017", "authors": "Jiang G, Huang C, Li J, Huang H, Jin H, Zhu J, Wu XR, Huang C", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "28223425", "url": "https://glygen.org/publication/PubMed/28223425" } ] }, { "title": "Inhibition of protein tyrosine phosphatase non-receptor type 2 by PTP inhibitor XIX: Its role as a multiphosphatase inhibitor.", "journal": "BMB reports", "date": "2017", "authors": "Le HTT, Cho YC, Cho S", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "28228214", "url": "https://glygen.org/publication/PubMed/28228214" } ] }, { "title": "p53 induces miR199a-3p to suppress SOCS7 for STAT3 activation and renal fibrosis in UUO.", "journal": "Scientific reports", "date": "2017", "authors": "Yang R, Xu X, Li H, Chen J, Xiang X, Dong Z, Zhang D", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "28240316", "url": "https://glygen.org/publication/PubMed/28240316" } ] }, { "title": "STAT3 promotes IFN\u03b3/TNF\u03b1-induced muscle wasting in an NF-\u03baB-dependent and IL-6-independent manner.", "journal": "EMBO molecular medicine", "date": "2017-05", "authors": "Ma Jennifer F, Sanchez Brenda J, Hall Derek T, Tremblay Anne-Marie K, Di Marco Sergio, Gallouzi Imed-Eddine", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "28264935", "url": "https://glygen.org/publication/PubMed/28264935" } ] }, { "title": "The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression.", "journal": "Nature communications", "date": "2017", "authors": "Ahn R, Sabourin V, Bolt AM, Hebert S, Totten S, De Jay N, Festa MC, Young YK, Im YK, Pawson T, Koromilas AE, Muller WJ, Mann KK, Kleinman CL, Ursini-Siegel J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "28276425", "url": "https://glygen.org/publication/PubMed/28276425" } ] }, { "title": "Myeloid-derived cullin 3 promotes STAT3 phosphorylation by inhibiting OGT expression and protects against intestinal inflammation.", "journal": "The Journal of experimental medicine", "date": "2017", "authors": "Li X, Zhang Z, Li L, Gong W, Lazenby AJ, Swanson BJ, Herring LE, Asara JM, Singer JD, Wen H", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "28280036", "url": 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{ "title": "STAT3 mediates multidrug resistance of Burkitt lymphoma cells by promoting antioxidant feedback.", "journal": "Biochemical and biophysical research communications", "date": "2017", "authors": "Zeng R, Tang Y, Zhou H, Liu Y, Huang J, Li L, Liu W, Feng Y, Zhou Y, Chen T, Zhang L, Zhong M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "28483518", "url": "https://glygen.org/publication/PubMed/28483518" } ] }, { "title": "Cryptotanshinone inhibits human glioma cell proliferation in vitro and in vivo through SHP-2-dependent inhibition of STAT3 activation.", "journal": "Cell death & disease", "date": "2017", "authors": "Lu L, Zhang S, Li C, Zhou C, Li D, Liu P, Huang M, Shen X", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": 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"id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "28550731", "url": "https://glygen.org/publication/PubMed/28550731" } ] }, { "title": "Silencing of type Igamma phosphatidylinositol phosphate kinase suppresses ovarian cancer cell proliferation, migration and invasion.", "journal": "Oncology reports", "date": "2017", "authors": "Cao S, Chen C, Xue J, Huang Y, Yang X, Ling K", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "28560454", "url": "https://glygen.org/publication/PubMed/28560454" } ] }, { "title": "Dysregulation of angiogenesis-specific signalling in adult testis results in xenograft degeneration.", "journal": "Scientific reports", "date": "2017-06-01", "authors": "Devi Lalitha, Pothana Lavanya, Goel Sandeep", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": 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"database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29309895", "url": "https://glygen.org/publication/PubMed/29309895" } ] }, { "title": "Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability.", "journal": "Nature communications", "date": "2018", "authors": "Williams JJL, Alotaiq N, Mullen W, Burchmore R, Liu L, Baillie GS, Schaper F, Pilch PF, Palmer TM", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29330478", "url": "https://glygen.org/publication/PubMed/29330478" } ] }, { "title": "Interleukin-6 promotes a sustained loss of endothelial barrier function via Janus kinase-mediated STAT3 phosphorylation and de novo protein synthesis.", "journal": "American journal of physiology. Cell physiology", "date": "2018-05-01", "authors": "Alsaffar Hiba, Martino Nina, Garrett Joshua P, Adam Alejandro P", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29351406", "url": "https://glygen.org/publication/PubMed/29351406" } ] }, { "title": "Visualization and quantification of dynamic STAT3 homodimerization in living cells using homoFluoppi.", "journal": "Scientific reports", "date": "2018", "authors": "Okada Y, Watanabe T, Shoji T, Taguchi K, Ogo N, Asai A", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29402895", "url": "https://glygen.org/publication/PubMed/29402895" } ] }, { "title": "Impact of STAT3 phosphorylation in glioblastoma stem cells radiosensitization and patient outcome.", "journal": "Oncotarget", "date": "2018", "authors": "Masliantsev K, Pinel B, Balbous A, Guichet PO, Tachon G, Milin S, Godet J, Duchesne M, Berger A, Petropoulos C, Wager M, Karayan-Tapon L", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29423098", "url": "https://glygen.org/publication/PubMed/29423098" } ] }, { "title": "Interaction between STAT3 and GLI1/tGLI1 oncogenic transcription factors promotes the aggressiveness of triple-negative breast cancers and HER2-enriched breast cancer.", "journal": "Oncogene", "date": "2018", "authors": "Sirkisoon SR, Carpenter RL, Rimkus T, Anderson A, Harrison A, Lange AM, Jin G, Watabe K, Lo HW", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29449694", "url": "https://glygen.org/publication/PubMed/29449694" } ] }, { "title": "Methyllucidone inhibits STAT3 activity by regulating the expression of the protein tyrosine phosphatase MEG2 in DU145 prostate carcinoma cells.", "journal": "Bioorganic & medicinal chemistry letters", "date": "2018", "authors": "Jin Y, Kim YH, Park JY, Lee YJ, Oh HM, Choi SK, Han DC, Kwon BM", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29456111", "url": "https://glygen.org/publication/PubMed/29456111" } ] }, { "title": "Novel synthetic bisindolylmaleimide alkaloids inhibit STAT3 activation by binding to the SH2 domain and suppress breast xenograft tumor growth.", "journal": "Oncogene", "date": "2018-05", "authors": "Li Xia, Ma Hongguang, Li Lin, Chen Yifan, Sun Xiao, Dong Zizheng, Liu Jing-Yuan, Zhu Weiming, Zhang Jian-Ting", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29456240", "url": "https://glygen.org/publication/PubMed/29456240" } ] }, { "title": "Under-expression of CK2beta subunit in ccRCC represents a complementary biomarker of p-STAT3 Ser727 that correlates with patient survival.", "journal": "Oncotarget", "date": "2018", "authors": "Vilardell J, Alcaraz E, Sarro E, Trilla E, Cuadros T, de Torres I, Plana M, Ramon Y Cajal S, Pinna LA, Ruzzene M, Morote J, Meseguer A, Itarte E", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29464030", "url": "https://glygen.org/publication/PubMed/29464030" } ] }, { "title": "Bilateral activation of STAT3 by phosphorylation at the tyrosine-705 (Y705) and serine-727 (S727) positions and its nuclear translocation in primary sensory neurons following unilateral sciatic nerve injury.", "journal": "Histochemistry and cell biology", "date": "2018", "authors": "Dubovy P, Hradilova-Svizenska I, Klusakova I, Kokosova V, Brazda V, Joukal M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29488000", "url": "https://glygen.org/publication/PubMed/29488000" } ] }, { "title": "STAT3 Gene Silencing by Aptamer-siRNA Chimera as Selective Therapeutic for Glioblastoma.", "journal": "Molecular therapy. Nucleic acids", "date": "2018", "authors": "Esposito CL, Nuzzo S, Catuogno S, Romano S, de Nigris F, de Franciscis V", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29499951", "url": "https://glygen.org/publication/PubMed/29499951" } ] }, { "title": "The AB loop and D-helix in binding site III of human Oncostatin M (OSM) are required for OSM receptor activation.", "journal": "The Journal of biological chemistry", "date": "2018", "authors": "Adrian-Segarra JM, Schindler N, Gajawada P, Lorchner H, Braun T, Poling J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29511087", "url": "https://glygen.org/publication/PubMed/29511087" } ] }, { "title": "Cancer-associated fibroblasts promote stem cell-like properties of hepatocellular carcinoma cells through IL-6/STAT3/Notch signaling.", "journal": "American journal of cancer research", "date": "2018", "authors": "Xiong S, Wang R, Chen Q, Luo J, Wang J, Zhao Z, Li Y, Wang Y, Wang X, Cheng B", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29511600", "url": "https://glygen.org/publication/PubMed/29511600" } ] }, { "title": "EAF2 and p53 Co-Regulate STAT3 Activation in Prostate Cancer.", "journal": "Neoplasia (New York, N.Y.)", "date": "2018", "authors": "Pascal LE, Wang Y, Zhong M, Wang D, Chakka AB, Yang Z, Li F, Song Q, Rigatti LH, Chaparala S, Chandran U, Parwani AV, Wang Z", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29518696", "url": "https://glygen.org/publication/PubMed/29518696" } ] }, { "title": "Histone deacetylase 3 promotes liver regeneration and liver cancer cells proliferation through signal transducer and activator of transcription 3 signaling pathway.", "journal": "Cell death & disease", "date": "2018", "authors": "Lu XF, Cao XY, Zhu YJ, Wu ZR, Zhuang X, Shao MY, Xu Q, Zhou YJ, Ji HJ, Lu QR, Shi YJ, Zeng Y, Bu H", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29540666", "url": "https://glygen.org/publication/PubMed/29540666" } ] }, { "title": "PhosphoLipid transfer protein (PLTP) exerts a direct pro-inflammatory effect on rheumatoid arthritis (RA) fibroblasts-like-synoviocytes (FLS) independently of its lipid transfer activity.", "journal": "PloS one", "date": "2018", "authors": "Audo R, Deckert V, Daien CI, Che H, Elhmioui J, Lemaire S, Pais de Barros JP, Desrumaux C, Combe B, Hahne M, Lagrost L, Morel J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29565987", "url": "https://glygen.org/publication/PubMed/29565987" } ] }, { "title": "Presence of stromal cells in a bioengineered tumor microenvironment alters glioblastoma migration and response to STAT3 inhibition.", "journal": "PloS one", "date": "2018", "authors": "Herrera-Perez RM, Voytik-Harbin SL, Sarkaria JN, Pollok KE, Fishel ML, Rickus JL", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29566069", "url": "https://glygen.org/publication/PubMed/29566069" } ] }, { "title": "YM155 decreases radiation-induced invasion and reverses epithelial-mesenchymal transition by targeting STAT3 in glioblastoma.", "journal": "Journal of translational medicine", "date": "2018-03-23", "authors": "Zhang Xin, Wang Xuehai, Xu Ran, Ji Jianxiong, Xu Yangyang, Han Mingzhi, Wei Yuzhen, Huang Bin, Chen Anjing, Zhang Qing, Li Wenjie, Wang Jian, Li Xingang, Qiu Chen", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29571296", "url": "https://glygen.org/publication/PubMed/29571296" } ] }, { "title": "Bt354 as a new STAT3 signaling pathway inhibitor against triple negative breast cancer.", "journal": "Journal of drug targeting", "date": "2018", "authors": "Chen Y, Ji M, Zhang S, Xue N, Xu H, Lin S, Chen X", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29595328", "url": "https://glygen.org/publication/PubMed/29595328" } ] }, { "title": "PGE2 mediates EGFR internalization and nuclear translocation via caveolin endocytosis promoting its transcriptional activity and proliferation in human NSCLC cells.", "journal": "Oncotarget", "date": "2018", "authors": "Bazzani L, Donnini S, Giachetti A, Christofori G, Ziche M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29599917", "url": "https://glygen.org/publication/PubMed/29599917" } ] }, { "title": "L61H46 shows potent efficacy against human pancreatic cancer through inhibiting STAT3 pathway.", "journal": "Cancer management and research", "date": "2018", "authors": "Bai E, Yang L, Xiang Y, Hu W, Li C, Lin J, Dai X, Liang G, Jin R, Zhao C", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29606890", "url": "https://glygen.org/publication/PubMed/29606890" } ] }, { "title": "STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle.", "journal": "PLoS pathogens", "date": "2018-04", "authors": "Morgan Ethan L, Wasson Christopher W, Hanson Lucy, Kealy David, Pentland Ieisha, McGuire Victoria, Scarpini Cinzia, Coleman Nicholas, Arthur J Simon C, Parish Joanna L, Roberts Sally, Macdonald Andrew", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29630659", "url": "https://glygen.org/publication/PubMed/29630659" } ] }, { "title": "GADD45A and CDKN1A are involved in apoptosis and cell cycle modulatory effects of viscumTT with further inactivation of the STAT3 pathway.", "journal": "Scientific reports", "date": "2018", "authors": "Kleinsimon S, Longmuss E, Rolff J, Jager S, Eggert A, Delebinski C, Seifert G", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29636527", "url": "https://glygen.org/publication/PubMed/29636527" } ] }, { "title": "TGF-beta1 expression in regulatory NK1.1(-)CD4(+)NKG2D(+) T cells dependents on the PI3K-p85alpha/JNK, NF-kappaB and STAT3 pathways.", "journal": "American journal of cancer research", "date": "2018", "authors": "Han S, Ding S, Miao X, Lin Z, Lu G, Xiao W, Ding Y, Qian L, Zhang Y, Jia X, Zhu G, Gong W", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29637003", "url": "https://glygen.org/publication/PubMed/29637003" } ] }, { "title": "Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes.", "journal": "PloS one", "date": "2018", "authors": "Baker J, Falconer AMD, Wilkinson DJ, Europe-Finner GN, Litherland GJ, Rowan AD", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29652915", "url": "https://glygen.org/publication/PubMed/29652915" } ] }, { "title": "Silibinin is a direct inhibitor of STAT3.", "journal": "Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association", "date": "2018", "authors": "Verdura S, Cuyas E, Llorach-Pares L, Perez-Sanchez A, Micol V, Nonell-Canals A, Joven J, Valiente M, Sanchez-Martinez M, Bosch-Barrera J, Menendez JA", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29660364", "url": "https://glygen.org/publication/PubMed/29660364" } ] }, { "title": "Cooperative STAT/NF-kappaB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression.", "journal": "Nature communications", "date": "2018", "authors": "Feist M, Schwarzfischer P, Heinrich P, Sun X, Kemper J, von Bonin F, Perez-Rubio P, Taruttis F, Rehberg T, Dettmer K, Gronwald W, Reinders J, Engelmann JC, Dudek J, Klapper W, Trumper L, Spang R, Oefner PJ, Kube D", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29666362", "url": "https://glygen.org/publication/PubMed/29666362" } ] }, { "title": "Cytokine Profile of Human Abdominal Aortic Aneurysm: Involvement of JAK/STAT Pathway.", "journal": "Annals of vascular diseases", "date": "2018", "authors": "Ohno T, Aoki H, Ohno S, Nishihara M, Furusho A, Hiromatsu S, Akashi H, Fukumoto Y, Tanaka H", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29682112", "url": "https://glygen.org/publication/PubMed/29682112" } ] }, { "title": "Curcumin interacts directly with the Cysteine 259 residue of STAT3 and induces apoptosis in H-Ras transformed human mammary epithelial cells.", "journal": "Scientific reports", "date": "2018", "authors": "Hahn YI, Kim SJ, Choi BY, Cho KC, Bandu R, Kim KP, Kim DH, Kim W, Park JS, Han BW, Lee J, Na HK, Cha YN, Surh YJ", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29686295", "url": "https://glygen.org/publication/PubMed/29686295" } ] }, { "title": "G3BP1 promotes tumor progression and metastasis through IL-6/G3BP1/STAT3 signaling axis in renal cell carcinomas.", "journal": "Cell death & disease", "date": "2018", "authors": "Wang Y, Fu D, Chen Y, Su J, Wang Y, Li X, Zhai W, Niu Y, Yue D, Geng H", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29717134", "url": "https://glygen.org/publication/PubMed/29717134" } ] }, { "title": "Myeloid-derived macrophages and secreted HSP90alpha induce pancreatic ductal adenocarcinoma development.", "journal": "Oncoimmunology", "date": "2018", "authors": "Chen CC, Chen LL, Li CP, Hsu YT, Jiang SS, Fan CS, Chua KV, Huang SX, Shyr YM, Chen LT, Huang TS", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29721383", "url": "https://glygen.org/publication/PubMed/29721383" } ] }, { "title": "Oct4 suppresses IRinduced premature senescence in breast cancer cells through STAT3- and NFkappaB-mediated IL24 production.", "journal": "International journal of oncology", "date": "2018", "authors": "Kim JY, Kim JC, Lee JY, Park MJ", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29749438", "url": "https://glygen.org/publication/PubMed/29749438" } ] }, { "title": "Overexpressed HO-1 is associated with reduced STAT3 activation in preeclampsia placenta and inhibits STAT3 phosphorylation in placental JEG-3 cells under hypoxia.", "journal": "Archives of medical science : AMS", "date": "2018", "authors": "Qu HM, Qu LP, Li XY, Pan XZ", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29765448", "url": "https://glygen.org/publication/PubMed/29765448" } ] }, { "title": "The critical role that STAT3 plays in glioma-initiating cells: STAT3 addiction in glioma.", "journal": "Oncotarget", "date": "2018", "authors": "Ganguly D, Fan M, Yang CH, Zbytek B, Finkelstein D, Roussel MF, Pfeffer LM", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29774125", "url": "https://glygen.org/publication/PubMed/29774125" } ] }, { "title": "Luteolin-Mediated Inhibition of Hepatic Stellate Cell Activation via Suppression of the STAT3 Pathway.", "journal": "International journal of molecular sciences", "date": "2018", "authors": "Cummins CB, Wang X, Nunez Lopez O, Graham G, Tie HY, Zhou J, Radhakrishnan RS", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29795016", "url": "https://glygen.org/publication/PubMed/29795016" } ] }, { "title": "Chemical and genetic inhibition of STAT3 sensitizes hepatocellular carcinoma cells to sorafenib induced cell death.", "journal": "International journal of biological sciences", "date": "2018", "authors": "Xie L, Zeng Y, Dai Z, He W, Ke H, Lin Q, Chen Y, Bu J, Lin D, Zheng M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29805309", "url": "https://glygen.org/publication/PubMed/29805309" } ] }, { "title": "Piperlongumine derivative, CG-06, inhibits STAT3 activity by direct binding to STAT3 and regulating the reactive oxygen species in DU145 prostate carcinoma cells.", "journal": "Bioorganic & medicinal chemistry letters", "date": "2018", "authors": "Kim YH, Yoon YJ, Lee YJ, Kim CH, Lee S, Choung DH, Han DC, Kwon BM", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29807795", "url": "https://glygen.org/publication/PubMed/29807795" } ] }, { "title": "Activation of STAT3 and Bcl-2 and reduction of reactive oxygen species (ROS) promote radioresistance in breast cancer and overcome of radioresistance with niclosamide.", "journal": "Oncogene", "date": "2018-09", "authors": "Lu Lu, Dong Jiali, Wang Lili, Xia Qing, Zhang Dan, Kim Hyejin, Yin Tao, Fan Saijun, Shen Qiang", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29855616", "url": "https://glygen.org/publication/PubMed/29855616" } ] }, { "title": "Interleukin-6/STAT3 signalling regulates adipocyte induced epithelial-mesenchymal transition in breast cancer cells.", "journal": "Scientific reports", "date": "2018", "authors": "Gyamfi J, Lee YH, Eom M, Choi J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29891854", "url": "https://glygen.org/publication/PubMed/29891854" } ] }, { "title": "Novel quinazoline-based sulfonamide derivative (3D) induces apoptosis in colorectal cancer by inhibiting JAK2-STAT3 pathway.", "journal": "OncoTargets and therapy", "date": "2018", "authors": "Al-Obeed O, Vaali-Mohammed MA, Eldehna WM, Al-Khayal K, Mahmood A, Abdel-Aziz HA, Zubaidi A, Alafeefy A, Abdulla M, Ahmad R", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29892198", "url": "https://glygen.org/publication/PubMed/29892198" } ] }, { "title": "CXCR7 silencing inhibits the migration and invasion of human tumor endothelial cells derived from hepatocellular carcinoma by suppressing STAT3.", "journal": "Molecular medicine reports", "date": "2018", "authors": "Wu Y, Tian L, Xu Y, Zhang M, Xiang S, Zhao J, Wang Z", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29901083", "url": "https://glygen.org/publication/PubMed/29901083" } ] }, { "title": "CRISPR/Cas9-mediated knockout of HBsAg inhibits proliferation and tumorigenicity of HBV-positive hepatocellular carcinoma cells.", "journal": "Journal of cellular biochemistry", "date": "2018", "authors": "Song J, Zhang X, Ge Q, Yuan C, Chu L, Liang HF, Liao Z, Liu Q, Zhang Z, Zhang B", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29904948", "url": "https://glygen.org/publication/PubMed/29904948" } ] }, { "title": "Inhibitory effects of isocryptotanshinone on gastric cancer.", "journal": "Scientific reports", "date": "2018", "authors": "Chen ZM, Huang L, Li MM, Meng L, Ying SC, Xu AM", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29915371", "url": "https://glygen.org/publication/PubMed/29915371" } ] }, { "title": "Systems modelling of the EGFR-PYK2-c-Met interaction network predicts and prioritizes synergistic drug combinations for triple-negative breast cancer.", "journal": "PLoS computational biology", "date": "2018", "authors": "Shin SY, Muller AK, Verma N, Lev S, Nguyen LK", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29920512", "url": "https://glygen.org/publication/PubMed/29920512" } ] }, { "title": "Compound K Induces Endoplasmic Reticulum Stress and Apoptosis in Human Liver Cancer Cells by Regulating STAT3.", "journal": "Molecules (Basel, Switzerland)", "date": "2018", "authors": "Zhang X, Zhang S, Sun Q, Jiao W, Yan Y, Zhang X", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29921768", "url": "https://glygen.org/publication/PubMed/29921768" } ] }, { "title": "C1q/TNF-related peptide 8 (CTRP8) promotes temozolomide resistance in human glioblastoma.", "journal": "Molecular oncology", "date": "2018", "authors": "Thanasupawat T, Glogowska 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"authors": "Rubini E, Altieri F, Chichiarelli S, Giamogante F, Carissimi S, Paglia G, Macone A, Eufemi M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30036966", "url": "https://glygen.org/publication/PubMed/30036966" } ] }, { "title": "Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids.", "journal": "Nature communications", "date": "2018", "authors": "Jung KB, Lee H, Son YS, Lee MO, Kim YD, Oh SJ, Kwon O, Cho S, Cho HS, Kim DS, Oh JH, Zilbauer M, Min JK, Jung CR, Kim J, Son MY", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30072687", "url": "https://glygen.org/publication/PubMed/30072687" } ] }, { "title": "Esculentoside A suppresses breast cancer stem cell growth through stemness 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"reference": [ { "type": "PubMed", "id": "30127373", "url": "https://glygen.org/publication/PubMed/30127373" } ] }, { "title": "The tyrosine phosphorylated pro-survival form of Fas intensifies the EGF-induced signal in colorectal cancer cells through the nuclear EGFR/STAT3-mediated pathway.", "journal": "Scientific reports", "date": "2018", "authors": "Ta NL, Chakrabandhu K, Huault S, Hueber AO", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30127519", "url": "https://glygen.org/publication/PubMed/30127519" } ] }, { "title": "STAT3 is a master regulator of epithelial identity and KRAS-driven tumorigenesis.", "journal": "Genes & development", "date": "2018", "authors": "D'Amico S, Shi J, Martin BL, Crawford HC, Petrenko O, Reich NC", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30135074", "url": "https://glygen.org/publication/PubMed/30135074" } ] }, { "title": "Lycorine Displays Potent Antitumor Efficacy in Colon Carcinoma by Targeting STAT3.", "journal": "Frontiers in pharmacology", "date": "2018", "authors": "Wu S, Qiu Y, Shao Y, Yin S, Wang R, Pang X, Ma J, Zhang C, Wu B, Koo S, Han L, Zhang Y, Gao X, Wang T, Yu H", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30135654", "url": "https://glygen.org/publication/PubMed/30135654" } ] }, { "title": "STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas.", "journal": "Nature communications", "date": "2018", "authors": "Pan YR, Chen CC, Chan YT, Wang HJ, Chien FT, Chen YL, Liu JL, Yang MH", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": 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"reference": [ { "type": "PubMed", "id": "30234199", "url": "https://glygen.org/publication/PubMed/30234199" } ] }, { "title": "Combination of resveratrol and 5-flurouracil enhanced anti-telomerase activity and apoptosis by inhibiting STAT3 and Akt signaling pathways in human colorectal cancer cells.", "journal": "Oncotarget", "date": "2018", "authors": "Chung SS, Dutta P, Austin D, Wang P, Awad A, Vadgama JV", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30250641", "url": "https://glygen.org/publication/PubMed/30250641" } ] }, { "title": "Sesquiterpene lactones-enriched fraction of Inula helenium L. induces apoptosis through inhibition of signal transducers and activators of transcription 3 signaling pathway in MDA-MB-231 breast cancer cells.", "journal": "Phytotherapy research : PTR", "date": "2018", "authors": "Chun J, Song K, Kim YS", "evidence": [ { 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Scott H, Cai Zhengdong, Yaszemski Michael J, Maran Avudaiappan", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30286779", "url": "https://glygen.org/publication/PubMed/30286779" } ] }, { "title": "YL064 directly inhibits STAT3 activity to induce apoptosis of multiple myeloma cells.", "journal": "Cell death discovery", "date": "2018", "authors": "Wang Y, Wu L, Cai H, Lei H, Ma CM, Yang L, Xu H, Zhu Q, Yao Z, Wu Y", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30302278", "url": "https://glygen.org/publication/PubMed/30302278" } ] }, { "title": "Indirubin suppresses ovarian cancer cell viabilities through the STAT3 signaling pathway.", "journal": "Drug design, development and therapy", "date": "2018", "authors": "Chen L, Wang J, Wu J, Zheng Q, Hu J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30323565", "url": "https://glygen.org/publication/PubMed/30323565" } ] }, { "title": "A new synthetic derivative of cryptotanshinone KYZ3 as STAT3 inhibitor for triple-negative breast cancer therapy.", "journal": "Cell death & disease", "date": "2018", "authors": "Zhang W, Yu W, Cai G, Zhu J, Zhang C, Li S, Guo J, Yin G, Chen C, Kong L", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30368518", "url": "https://glygen.org/publication/PubMed/30368518" } ] }, { "title": "2'-Hydroxycinnamaldehyde inhibits proliferation and induces apoptosis via signal transducer and activator of transcription 3 inactivation and reactive oxygen species generation.", "journal": "Cancer science", "date": "2019", "authors": "Yoon YJ, Kim YH, Lee YJ, Choi J, Kim CH, Han DC, Kwon BM", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30375708", "url": "https://glygen.org/publication/PubMed/30375708" } ] }, { "title": "Dual androgen receptor (AR) and STAT3 inhibition by a compound targeting the AR amino-terminal domain.", "journal": "Pharmacology research & perspectives", "date": "2018-12", "authors": "Hua Yaping, Azeem Waqas, Shen Yunheng, Zhang Shoude, Olsen Jan R, \u00d8yan Anne M, Ke Xisong, Zhang Weidong, Kalland Karl-Henning", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30410767", "url": "https://glygen.org/publication/PubMed/30410767" } ] }, { "title": "PLOD3 promotes lung metastasis via regulation of STAT3.", "journal": "Cell death & disease", "date": "2018", "authors": "Baek JH, Yun HS, Kwon GT, Kim JY, Lee CW, Song JY, Um HD, Kang CM, Park JK, Kim JS, Kim EH, Hwang SG", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30442941", "url": "https://glygen.org/publication/PubMed/30442941" } ] }, { "title": "ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases.", "journal": "Frontiers in immunology", "date": "2018", "authors": "Glal D, Sudhakar JN, Lu HH, Liu MC, Chiang HY, Liu YC, Cheng CF, Shui JW", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30455690", "url": "https://glygen.org/publication/PubMed/30455690" } ] }, { "title": "Comparison of the antifibrotic effects of the pan-histone deacetylase-inhibitor panobinostat versus the IPF-drug pirfenidone in fibroblasts from patients with idiopathic pulmonary fibrosis.", "journal": "PloS one", "date": "2018", "authors": "Korfei M, Stelmaszek D, MacKenzie B, Skwarna S, Chillappagari S, Bach AC, Ruppert C, Saito S, Mahavadi P, Klepetko W, Fink L, Seeger W, Lasky JA, Pullamsetti SS, Kramer OH, Guenther A", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30481203", "url": "https://glygen.org/publication/PubMed/30481203" } ] }, { "title": "Niclosamide Inhibits Cell Growth and Enhances Drug Sensitivity of Hepatocellular Carcinoma Cells via STAT3 Signaling Pathway.", "journal": "Journal of Cancer", "date": "2018", "authors": "Wang C, Zhou X, Xu H, Shi X, Zhao J, Yang M, Zhang L, Jin X, Hu Y, Li X, Xiao X, Liao M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": 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experimental & clinical cancer research : CR", "date": "2018", "authors": "Dai X, Yin C, Zhang Y, Guo G, Zhao C, Wang O, Xiang Y, Zhang X, Liang G", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30577812", "url": "https://glygen.org/publication/PubMed/30577812" } ] }, { "title": "A Possible Reason to Induce Acute Graft-vs.-Host Disease After Hematopoietic Stem Cell Transplantation: Lack of Sirtuin-1 in CD4(+) T Cells.", "journal": "Frontiers in immunology", "date": "2018", "authors": "Xu YJ, Chen FP, Chen Y, Fu B, Liu EY, Zou L, Liu LX", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30622543", "url": "https://glygen.org/publication/PubMed/30622543" } ] }, { "title": "STAT3 enhances the constitutive activity of AGC kinases in melanoma by transactivating PDK1.", "journal": "Cell & bioscience", "date": "2019", "authors": "Picco ME, Castro MV, Quezada MJ, Barbero G, Villanueva MB, Fernandez NB, Kim H, Lopez-Bergami P", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30622697", "url": "https://glygen.org/publication/PubMed/30622697" } ] }, { "title": "Atorvastatin Prevents Myocardial Fibrosis in Spontaneous Hypertension via Interleukin-6 (IL-6)/Signal Transducer and Activator of Transcription 3 (STAT3)/Endothelin-1 (ET-1) Pathway.", "journal": "Medical science monitor : international medical journal of experimental and clinical research", "date": "2019", "authors": "Fang T, Guo B, Xue L, Wang L", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30631031", "url": 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C", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30674340", "url": "https://glygen.org/publication/PubMed/30674340" } ] }, { "title": "Robustness and Information Transfer within IL-6-induced JAK/STAT Signalling.", "journal": "Communications biology", "date": "2019", "authors": "Billing Ulrike, Jetka Tomasz, Nortmann Lukas, Wundrack Nicole, Komorowski Michal, Waldherr Steffen, Schaper Fred, Dittrich Anna", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30675525", "url": "https://glygen.org/publication/PubMed/30675525" } ] }, { "title": "Myosin 1F Regulates M1-Polarization by Stimulating Intercellular Adhesion in Macrophages.", "journal": "Frontiers in immunology", "date": "2018", "authors": "Piedra-Quintero ZL, Serrano C, Villegas-Sepulveda N, Maravillas-Montero JL, Romero-Ramirez S, Shibayama M, Medina-Contreras O, Nava P, Santos-Argumedo L", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30687322", "url": "https://glygen.org/publication/PubMed/30687322" } ] }, { "title": "BP1102 exerts an antitumor effect on the AGS human gastric cancer cell line through modulating the STAT3 and MAPK signaling pathways.", "journal": "Molecular medicine reports", "date": "2019", "authors": "Jiang X, Tang J, Wu M, Chen S, Xu Z, Wang H, Wang H, Yu X, Li Z, Teng L", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30720080", "url": "https://glygen.org/publication/PubMed/30720080" } ] }, { "title": "Downregulation of protein disulfideisomerase A3 expression inhibits cell proliferation and induces apoptosis through STAT3 signaling in hepatocellular carcinoma.", "journal": "International journal of oncology", "date": "2019", "authors": "Kondo R, Ishino K, Wada R, Takata H, Peng WX, Kudo M, Kure S, Kaneya Y, Taniai N, Yoshida H, Naito Z", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30720090", "url": "https://glygen.org/publication/PubMed/30720090" } ] }, { "title": "MicroRNA-122 supports robust innate immunity in hepatocytes by targeting the RTKs/STAT3 signaling pathway.", "journal": "eLife", "date": "2019", "authors": "Xu H, Xu SJ, Xie SJ, Zhang Y, Yang JH, Zhang WQ, Zheng MN, Zhou H, Qu LH", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30735121", "url": "https://glygen.org/publication/PubMed/30735121" } ] }, { "title": "Attenuation of STAT3 Phosphorylation Promotes Apoptosis and Chemosensitivity in Human Osteosarcoma Induced by Raddeanin A.", "journal": "International journal of biological sciences", "date": "2019", "authors": "Wang Z, Wang C, Zuo D, Zhang T, Yin F, Zhou Z, Wang H, Xu J, Mao M, Wang G, Hua Y, Sun W, Cai Z", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30745853", "url": "https://glygen.org/publication/PubMed/30745853" } ] }, { "title": "PKM2-regulated STAT3 promotes esophageal squamous cell carcinoma progression via TGF-beta1-induced EMT.", "journal": "Journal of cellular biochemistry", "date": "2019", "authors": "Ma R, Liu Q, Zheng S, Liu T, Tan D, Lu X", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30756445", "url": 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Zhang M, Lan H, Zhang X, Xie Q, Jin G, Xu C", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30770798", "url": "https://glygen.org/publication/PubMed/30770798" } ] }, { "title": "Oestrogen inhibits PTPRO to prevent the apoptosis of renal podocytes.", "journal": "Experimental and therapeutic medicine", "date": "2019", "authors": "Ren W, Yi H, Bao Y, Liu Y, Gao X", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30783489", "url": "https://glygen.org/publication/PubMed/30783489" } ] }, { "title": "m(6)A methylation controls pluripotency of porcine induced pluripotent stem cells by targeting SOCS3/JAK2/STAT3 pathway in a YTHDF1/YTHDF2-orchestrated manner.", "journal": "Cell death & disease", "date": "2019", "authors": "Wu R, Liu Y, Zhao Y, Bi Z, Yao Y, Liu Q, Wang F, Wang Y, Wang X", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30787270", "url": "https://glygen.org/publication/PubMed/30787270" } ] }, { "title": "ING5 inhibits lung cancer invasion and epithelial-mesenchymal transition by inhibiting the WNT/beta-catenin pathway.", "journal": "Thoracic cancer", "date": "2019", "authors": "Liu XL, Meng J, Zhang XT, Liang XH, Zhang F, Zhao GR, Zhang T", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30810286", "url": "https://glygen.org/publication/PubMed/30810286" } ] }, { "title": "ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis.", "journal": "Nature communications", "date": "2019", "authors": "Hoeman CM, Cordero FJ, Hu G, Misuraca K, Romero MM, Cardona HJ, Nazarian J, Hashizume R, McLendon R, Yu P, Procissi D, Gadd S, Becher OJ", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30833574", "url": "https://glygen.org/publication/PubMed/30833574" } ] }, { "title": "Sustained NF-kappaB-STAT3 signaling promotes resistance to Smac mimetics in Glioma stem-like cells but creates a vulnerability to EZH2 inhibition.", "journal": "Cell death discovery", "date": "2019", "authors": "da Hora CC, Pinkham K, Carvalho L, Zinter M, Tabet E, Nakano I, Tannous BA, Badr CE", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30854231", "url": "https://glygen.org/publication/PubMed/30854231" } ] }, { "title": "p53-targeted lincRNA-p21 acts as a tumor suppressor by inhibiting JAK2/STAT3 signaling pathways in head and neck squamous cell carcinoma.", "journal": "Molecular cancer", "date": "2019", "authors": "Jin S, Yang X, Li J, Yang W, Ma H, Zhang Z", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30857539", "url": "https://glygen.org/publication/PubMed/30857539" } ] }, { "title": "STOML2 as a novel prognostic biomarker modulates cell proliferation, motility and chemo-sensitivity via IL6-Stat3 pathway in head and neck squamous cell carcinoma.", "journal": "American journal of translational research", "date": "2019", "authors": "Qu H, Jiang W, Wang Y, Chen P", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30899371", "url": "https://glygen.org/publication/PubMed/30899371" } ] }, { "title": "Endothelial cell-derived nidogen-1 inhibits migration of SK-BR-3 breast cancer cells.", "journal": "BMC cancer", "date": "2019", "authors": "Ferraro DA, Patella F, Zanivan S, Donato C, Aceto N, Giannotta M, Dejana E, Diepenbruck M, Christofori G, Buess M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30947697", "url": "https://glygen.org/publication/PubMed/30947697" } ] }, { "title": "Functional interplay between NF-\u03baB-inducing kinase and c-Abl kinases limits response to Aurora inhibitors in multiple myeloma.", "journal": "Haematologica", "date": "2019-12", "authors": "Mazzera Laura, Abeltino Manuela, Lombardi Guerino, Cantoni Anna Maria, Ria Roberto, Ricca Micaela, Saltarella Ilaria, Naponelli Valeria, Rizzi Federica Maria Angela, Perris Roberto, Corradi Attilio, Vacca Angelo, Bonati Antonio, Lunghi Paolo", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": 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"P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30950039", "url": "https://glygen.org/publication/PubMed/30950039" } ] }, { "title": "Knockdown of STAT3 targets a subpopulation of invasive melanoma stem-like cells.", "journal": "Cell biology international", "date": "2019", "authors": "Kulesza DW, Przanowski P, Kaminska B", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30958597", "url": "https://glygen.org/publication/PubMed/30958597" } ] }, { "title": "High-intensity focused ultrasound inhibits invasion and metastasis of colon cancer cells by enhancing microRNA-124-mediated suppression of STAT3.", "journal": "FEBS open bio", "date": "2019", "authors": "Li M, Wan G, Yu H, Xiong W", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30980700", "url": "https://glygen.org/publication/PubMed/30980700" } ] }, { "title": "Cycloastragenol can negate constitutive STAT3 activation and promote paclitaxel-induced apoptosis in human gastric cancer cells.", "journal": "Phytomedicine : international journal of phytotherapy and phytopharmacology", "date": "2019", "authors": "Hwang ST, Kim C, Lee JH, Chinnathambi A, Alharbi SA, Shair OHM, Sethi G, Ahn KS", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30981183", "url": "https://glygen.org/publication/PubMed/30981183" } ] }, { "title": "Dual blockage of STAT3 and ERK1/2 eliminates radioresistant GBM cells.", "journal": "Redox biology", "date": "2019", "authors": "Xie B, Zhang L, Hu W, Fan M, Jiang N, Duan Y, Jing D, Xiao W, Fragoso RC, Lam KS, Sun LQ, Li JJ", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30986607", "url": "https://glygen.org/publication/PubMed/30986607" } ] }, { "title": "JAK3/STAT3 oncogenic pathway and PRDM1 expression stratify clinicopathologic features of extranodal NK/Tcell lymphoma, nasal type.", "journal": "Oncology reports", "date": "2019", "authors": "Liu J, Liang L, Li D, Nong L, Zheng Y, Huang S, Zhang B, Li T", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31002364", "url": "https://glygen.org/publication/PubMed/31002364" } ] }, { "title": "STAT3 Post-Translational Modifications Drive Cellular Signaling Pathways in Prostate Cancer Cells.", "journal": "International journal of molecular sciences", "date": "2019", "authors": "Cocchiola R, Rubini E, Altieri F, Chichiarelli S, Paglia G, Romaniello D, Carissimi S, Giorgi A, Giamogante F, Macone A, Perugia G, Gurtner A, Eufemi M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31013746", "url": "https://glygen.org/publication/PubMed/31013746" } ] }, { "title": "Infiltrating CD4+ T cells attenuate chemotherapy sensitivity in prostate cancer via CCL5 signaling.", "journal": "The Prostate", "date": "2019", "authors": "Xiang P, Jin S, Yang Y, Sheng J, He Q, Song Y, Yu W, Hu S, Jin J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31018021", "url": "https://glygen.org/publication/PubMed/31018021" } ] }, { "title": "Discovery of fluorescent coumarin-benzo[b]thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors.", "journal": "European journal of medicinal chemistry", "date": "2019", "authors": "Cai G, Yu W, Song D, Zhang W, Guo J, Zhu J, Ren Y, Kong L", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31048139", "url": "https://glygen.org/publication/PubMed/31048139" } ] }, { "title": "Novel Galiellalactone Analogues Can Target STAT3 Phosphorylation and Cause Apoptosis in Triple-Negative Breast Cancer.", "journal": "Biomolecules", "date": "2019-05-03", "authors": "Ko Hyejin, Lee Jong Hyun, Kim Hyun Su, Kim Taewoo, Han Young Taek, Suh Young-Ger, Chun Jaemoo, Kim Yeong Shik, Ahn Kwang Seok", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31058868", "url": "https://glygen.org/publication/PubMed/31058868" } ] }, { "title": "CD28 Individual Signaling Up-regulates Human IL-17A Expression by Promoting the Recruitment of RelA/NF-kappaB and STAT3 Transcription Factors on the Proximal Promoter.", "journal": "Frontiers in immunology", "date": "2019", "authors": "Kunkl M, Mastrogiovanni M, Porciello N, Caristi S, Monteleone E, Arcieri S, Tuosto L", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31068940", "url": "https://glygen.org/publication/PubMed/31068940" } ] }, { "title": "A novel STAT3 inhibitor, HJC0152, exerts potent antitumor activity in glioblastoma.", "journal": "American journal of cancer research", "date": "2019", "authors": "Li Z, Zhu T, Xu Y, Wu C, Chen J, Ren Y, Kong L, Sun S, Guo W, Wang Y, Jing C, Dong J, Zhou J, Zhang L, Shen Q, Zhou X", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31105997", "url": "https://glygen.org/publication/PubMed/31105997" } ] }, { "title": "Peri-tumor fibroblasts promote tumorigenesis and metastasis of hepatocellular carcinoma via Interleukin6/STAT3 signaling pathway.", "journal": "Cancer management and research", "date": "2019", "authors": "Zhao Z, Xiong S, Wang R, Li Y, Wang X, Wang Y, Bai S, Chen W, Zhao Y, Cheng B", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31118769", "url": "https://glygen.org/publication/PubMed/31118769" } ] }, { "title": "15-Keto prostaglandin E2 suppresses STAT3 signaling and inhibits breast cancer cell growth and progression.", "journal": "Redox biology", "date": "2019-05", "authors": "Lee Eun Ji, Kim Su-Jung, Hahn Young-Il, Yoon Hyo-Jin, Han Bitnara, Kim Kyeojin, Lee Seungbeom, Kim Kwang Pyo, Suh Young Ger, Na Hye-Kyung, Surh Young-Joon", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31129031", "url": "https://glygen.org/publication/PubMed/31129031" } ] }, { "title": "AKR1C1 controls cisplatin-resistance in head and neck squamous cell carcinoma through cross-talk with the STAT1/3 signaling pathway.", "journal": "Journal of experimental & clinical cancer research : CR", "date": "2019", "authors": "Chang WM, Chang YC, Yang YC, Lin SK, Chang PM, Hsiao M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31182137", "url": "https://glygen.org/publication/PubMed/31182137" } ] }, { "title": "Transcriptomic study of the mechanism of anoikis resistance in head and neck squamous carcinoma.", "journal": "PeerJ", "date": "2019", "authors": "Guo Chen, Xu Ling-Feng, Li Hui-Min, Wang Wei, Guo Ji-Hua, Jia Meng-Qi, Jia Rong, Jia Jun", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31198634", "url": "https://glygen.org/publication/PubMed/31198634" } ] }, { "title": "3-Deoxy-2\u03b2,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells.", "journal": "Acta pharmacologica Sinica", "date": "2019-12", "authors": "Shan Hui, Yao Sheng, Ye Yang, Yu Qiang", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31201357", "url": "https://glygen.org/publication/PubMed/31201357" } ] }, { "title": "Analysis of interleukin-20 receptor complexes in trabecular meshwork cells and effects of cytokine signaling in anterior segment perfusion culture.", "journal": "Molecular vision", "date": "2019", "authors": "Keller KE, Yang YF, Sun YY, Walter MR, Wirtz MK", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31205408", "url": "https://glygen.org/publication/PubMed/31205408" } ] }, { "title": "Hirsutanol A Attenuates Lipopolysaccharide-Mediated Matrix Metalloproteinase 9 Expression and Cytokines Production and Improves Endotoxemia-Induced Acute Sickness Behavior and Acute Lung Injury.", "journal": "Marine drugs", "date": "2019", "authors": "Jan JS, Yang CH, Wang MH, Lin FL, Yen JL, Hsieh I, Khotimchenko M, Lee TH, Hsiao G", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31213027", "url": "https://glygen.org/publication/PubMed/31213027" } ] }, { "title": "Autocrine STAT3 activation in HPV positive cervical cancer through a virus-driven Rac1-NFkappaB-IL-6 signalling axis.", "journal": "PLoS pathogens", "date": "2019", "authors": "Morgan EL, Macdonald A", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31226168", "url": "https://glygen.org/publication/PubMed/31226168" } ] }, { "title": "ER stress abrogates the immunosuppressive effect of IL-10 on human macrophages through inhibition of STAT3 activation.", "journal": "Inflammation research : official journal of the European Histamine Research Society ... [et al.]", "date": "2019", "authors": "Hansen IS, Schoonejans JM, Sritharan L, van Burgsteden JA, Ambarus CA, Baeten DLP, den Dunnen J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31227842", "url": "https://glygen.org/publication/PubMed/31227842" } ] }, { "title": "Blockade of STAT3 Causes Severe In Vitro and In Vivo Maturation Defects in Intestinal Organoids Derived from Human Embryonic Stem Cells.", "journal": "Journal of clinical medicine", "date": "2019", "authors": "Jung KB, Kwon O, Lee MO, Lee H, Son YS, Habib O, Oh JH, Cho HS, Jung CR, Kim J, Son MY", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31277507", "url": "https://glygen.org/publication/PubMed/31277507" } ] }, { "title": "Napabucasin, a novel STAT3 inhibitor suppresses proliferation, invasion and stemness of glioblastoma cells.", "journal": "Journal of experimental & clinical cancer research : CR", "date": "2019", "authors": "Han D, Yu T, Dong N, Wang B, Sun F, Jiang D", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31277685", "url": "https://glygen.org/publication/PubMed/31277685" } ] }, { "title": "Intracellular Signaling in Key Pathways Is Induced by Treatment with Ultrasound and Microbubbles in a Leukemia Cell Line, but Not in Healthy Peripheral Blood Mononuclear Cells.", "journal": "Pharmaceutics", "date": "2019", "authors": "Haugse R, Langer A, Gullaksen SE, Sundoy SM, Gjertsen BT, Kotopoulis S, McCormack E", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31284599", "url": 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Cell Surface Expression and Viability of Tamoxifen-Resistant Breast Cancer Cells.", "journal": "Neoplasia (New York, N.Y.)", "date": "2019-08", "authors": "Tseng Chun-Chih, Zhang Pu, Lee Amy S", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31306849", "url": "https://glygen.org/publication/PubMed/31306849" } ] }, { "title": "MEK inhibition drives anti-viral defence in RV but not RSV challenged human airway epithelial cells through AKT/p70S6K/4E-BP1 signalling.", "journal": "Cell communication and signaling : CCS", "date": "2019", "authors": "Baturcam E, Vollmer S, Schluter H, Maciewicz RA, Kurian N, Vaarala O, Ludwig S, Cunoosamy DM", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31319869", "url": 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"http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31337063", "url": "https://glygen.org/publication/PubMed/31337063" } ] }, { "title": "Metformin reverses mesenchymal phenotype of primary breast cancer cells through STAT3/NF-kappaB pathways.", "journal": "BMC cancer", "date": "2019", "authors": "Esparza-Lopez J, Alvarado-Munoz JF, Escobar-Arriaga E, Ulloa-Aguirre A, de Jesus Ibarra-Sanchez M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31337349", "url": "https://glygen.org/publication/PubMed/31337349" } ] }, { "title": "Pyruvate Plays a Main Role in the Antitumoral Selectivity of Cold Atmospheric Plasma in Osteosarcoma.", "journal": "Scientific reports", "date": "2019", "authors": "Tornin J, Mateu-Sanz M, Rodriguez A, Labay C, Rodriguez R, Canal C", "evidence": [ { "database": "iPTMnet", "id": 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Lu VM, Parney IF, Daniels DJ", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31361777", "url": "https://glygen.org/publication/PubMed/31361777" } ] }, { "title": "DNMT3a promotes proliferation by activating the STAT3 signaling pathway and depressing apoptosis in pancreatic cancer.", "journal": "Cancer management and research", "date": "2019", "authors": "Jing W, Song N, Liu YP, Qu XJ, Qi YF, Li C, Hou KZ, Che XF, Yang XH", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31372043", "url": "https://glygen.org/publication/PubMed/31372043" } ] }, { "title": "Hepatectomy promotes recurrence of liver cancer by enhancing IL-11-STAT3 signaling.", "journal": "EBioMedicine", "date": "2019", "authors": "Wang D, Zheng X, Fu B, Nian Z, Qian Y, Sun R, Tian Z, Wei H", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31375423", "url": "https://glygen.org/publication/PubMed/31375423" } ] }, { "title": "Niclosamide reverses adipocyte induced epithelial-mesenchymal transition in breast cancer cells via suppression of the interleukin-6/STAT3 signalling axis.", "journal": "Scientific reports", "date": "2019", "authors": "Gyamfi J, Lee YH, Min BS, Choi J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31383893", "url": "https://glygen.org/publication/PubMed/31383893" } ] }, { "title": "NPM-ALK Is a Key Regulator of the Oncoprotein FOXM1 in ALK-Positive Anaplastic Large Cell Lymphoma.", "journal": "Cancers", "date": "2019", "authors": "Haque M, Li J, Huang YH, Almowaled M, Barger CJ, Karpf AR, Wang P, Chen W, Turner SD, Lai R", "evidence": [ { "database": "Reactome", "id": "R-HSA-9725371", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9725371" }, { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31390744", "url": "https://glygen.org/publication/PubMed/31390744" } ] }, { "title": "Novel interactions between ERalpha-36 and STAT3 mediate breast cancer cell migration.", "journal": "Cell communication and signaling : CCS", "date": "2019", "authors": "Xiang Y, Li JP, Guo W, Wang DQ, Yao A, Zhang HM, Huang F, Li HH, Dai ZT, Zhang ZJ, Li H, Tan Y, Chen K, Bao LY, Liao XH", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31409371", "url": "https://glygen.org/publication/PubMed/31409371" } ] }, { "title": "The Natural-Based Antitumor Compound T21 Decreases Survivin Levels through Potent STAT3 Inhibition in Lung Cancer Models.", "journal": "Biomolecules", "date": "2019", "authors": "Martinez-Garcia D, Perez-Hernandez M, Korrodi-Gregorio L, Quesada R, Ramos R, Baixeras N, Perez-Tomas R, Soto-Cerrato V", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31412593", "url": "https://glygen.org/publication/PubMed/31412593" } ] }, { "title": "Sodium cantharidate targets STAT3 and abrogates EGFR inhibitor resistance in osteosarcoma.", "journal": "Aging", "date": "2019", "authors": "Ji XL, He M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31422383", "url": "https://glygen.org/publication/PubMed/31422383" } ] }, { "title": "Antagonistic Effects of IL-4 on IL-17A-Mediated Enhancement of Epidermal Tight Junction Function.", "journal": "International journal of molecular sciences", "date": "2019", "authors": "Brewer MG, Yoshida T, Kuo FI, Fridy S, Beck LA, De Benedetto A", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31438472", "url": "https://glygen.org/publication/PubMed/31438472" } ] }, { "title": "Hyper-Activation of STAT3 Sustains Progression of Non-Papillary Basal-Type Bladder Cancer via FOSL1 Regulome.", "journal": "Cancers", "date": "2019", "authors": "Gatta LB, Melocchi L, Bugatti M, Missale F, Lonardi S, Zanetti B, Cristinelli L, Belotti S, Simeone C, Ronca R, Grillo E, Licini S, Bresciani D, Tardanico R, Chan SR, Giurisato E, Calza S, Vermi W", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31438567", "url": "https://glygen.org/publication/PubMed/31438567" } ] }, { "title": "MicroRNA-34a/IL-6R pathway as a potential therapeutic target for ovarian high-grade serous carcinoma.", "journal": "Oncotarget", "date": "2019", "authors": "Yokomizo R, Yanaihara N, Yamaguchi N, Saito M, Kawabata A, Takahashi K, Takenaka M, Yamada K, Shapiro JS, Okamoto A", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31448054", "url": "https://glygen.org/publication/PubMed/31448054" } ] }, { "title": "Evidence for a non-canonical JAK/STAT signaling pathway in the synthesis of the brain's major ion channels and neurotransmitter receptors.", "journal": "BMC genomics", "date": "2019-08-28", "authors": "Hixson Kathryn M, Cogswell Meaghan, Brooks-Kayal Amy R, Russek Shelley J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": 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Giamogante F, Macone A, Perugia G, Magliocca FM, Gurtner A, Maras B, Ragno R, Patsilinakos A, Manganaro R, Eufemi M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31500219", "url": "https://glygen.org/publication/PubMed/31500219" } ] }, { "title": "Niclosamide, an antihelmintic drug, enhances efficacy of PD-1/PD-L1 immune checkpoint blockade in non-small cell lung cancer.", "journal": "Journal for immunotherapy of cancer", "date": "2019-09-11", "authors": "Luo Fan, Luo Min, Rong Qi-Xiang, Zhang Hong, Chen Zhen, Wang Fang, Zhao Hong-Yun, Fu Li-Wu", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31511071", "url": "https://glygen.org/publication/PubMed/31511071" } ] }, { "title": "Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling.", "journal": "Cell communication and signaling : CCS", "date": "2019", "authors": "Nath D, Li X, Mondragon C, Post D, Chen M, White JR, Hryniewicz-Jankowska A, Caza T, Kuznetsov VA, Hehnly H, Jamaspishvili T, Berman DM, Zhang F, Kung SHY, Fazli L, Gleave ME, Bratslavsky G, Pandolfi PP, Kotula L", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31530281", "url": "https://glygen.org/publication/PubMed/31530281" } ] }, { "title": "Gp130 degradation induced by epirubicin contributes to chemotherapy efficacy.", "journal": "Biochemical and biophysical research communications", "date": "2019-11-12", "authors": "Liu Fangming, Jin Haizhen, Shen Jinhong, Wu Dan, Tian Ye, Huang Chao", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": 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Fan, Ren Chunxia, Wang Jingshu, Wang Shuoer, Yang Lina, Han Xianghui, Chen Yaping, Tong Guoqing, Yang Gong", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31597912", "url": "https://glygen.org/publication/PubMed/31597912" } ] }, { "title": "Sanguinarine exhibits potent efficacy against cervical cancer cells through inhibiting the STAT3 pathway in vitro and in vivo.", "journal": "Cancer management and research", "date": "2019", "authors": "Zhang Huijuan, Zhang Jing, Venkat Puja S, Gu Chenglei, Meng Yuanguang", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31616177", "url": "https://glygen.org/publication/PubMed/31616177" } ] }, { "title": "Polo-like kinase 3 inhibits glucose metabolism in colorectal cancer by targeting HSP90/STAT3/HK2 signaling.", "journal": "Journal of experimental & clinical cancer research : CR", "date": "2019-10-26", "authors": "Ou Baochi, Sun Hongze, Zhao Jingkun, Xu Zhuoqing, Liu Yuan, Feng Hao, Peng Zhihai", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31655629", "url": "https://glygen.org/publication/PubMed/31655629" } ] }, { "title": "A self-enforcing HOXA11/Stat3 feedback loop promotes stemness properties and peritoneal metastasis in gastric cancer cells.", "journal": "Theranostics", "date": "2019", "authors": "Wang C, Shi M, Ji J, Cai Q, Jiang J, Zhang H, Zhu Z, Zhang J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31695791", "url": "https://glygen.org/publication/PubMed/31695791" } ] }, { "title": "FA2H Exhibits Tumor Suppressive Roles on Breast Cancers via Cancer Stemness Control.", "journal": "Frontiers in oncology", "date": "2019", "authors": "Dai Xiaofeng, Zhang Shuo, Cheng Hongye, Cai Dongyan, Chen Xiao, Huang Zhaohui", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31709178", "url": "https://glygen.org/publication/PubMed/31709178" } ] }, { "title": "The Dichotomous Nature of AZ5104 (an EGFR Inhibitor) Towards ROR\u03b3 and ROR\u03b3T.", "journal": "International journal of molecular sciences", "date": "2019-11-17", "authors": "Kara\u015b Kaja, Sa\u0142kowska Anna, Karwaciak Iwona, Walczak-Drzewiecka Aurelia, Dastych Jaros\u0142aw, Bachorz Rafa\u0142 A, Ratajewski Marcin", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31744223", "url": 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Severi Ilenia, Monaco Federica, Reguzzoni Marcella, Tomasetti Marco, Dani Christian, Cinti Saverio, Giordano Antonio", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31781039", "url": "https://glygen.org/publication/PubMed/31781039" } ] }, { "title": "LncRNA-encoded polypeptide ASRPS inhibits triple-negative breast cancer angiogenesis.", "journal": "The Journal of experimental medicine", "date": "2020-03-02", "authors": "Wang Yirong, Wu Siqi, Zhu Xun, Zhang Liyuan, Deng Jieqiong, Li Fang, Guo Binbin, Zhang Shenghua, Wu Rui, Zhang Zheng, Wang Kexin, Lu Jiachun, Zhou Yifeng", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31816634", "url": "https://glygen.org/publication/PubMed/31816634" } ] }, { "title": "In Chronic Lymphocytic Leukemia the 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{ "title": "Berbamine Enhances the Efficacy of Gefitinib by Suppressing STAT3 Signaling in Pancreatic Cancer Cells.", "journal": "OncoTargets and therapy", "date": "2019", "authors": "Hu Bingren, Cai Huajie, Yang Shouzhang, Tu Jinfu, Huang Xiaming, Chen Gang", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "31920333", "url": "https://glygen.org/publication/PubMed/31920333" } ] }, { "title": "SSEA3 and Sialyl Lewis a Glycan Expression Is Controlled by B3GALT5 LTR through Lamin A-NFYA and SIRT1-STAT3 Signaling in Human ES Cells.", "journal": "Cells", "date": "2020-01-10", "authors": "Cai Bi-He, Lee Hsueh-Yi, Chou Chi-Kan, Wu Po-Han, Huang Hsiang-Chi, Chao Chia-Chun, Chung Hsiao-Yu, Kannagi Reiji", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": 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Gong", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "32080166", "url": "https://glygen.org/publication/PubMed/32080166" } ] }, { "title": "KCP10043F Represses the Proliferation of Human Non-Small Cell Lung Cancer Cells by Caspase-Mediated Apoptosis via STAT3 Inactivation.", "journal": "Journal of clinical medicine", "date": "2020-03-05", "authors": "Lee Jeong-Hun, Lee Hwi-Ho, Ryu Ki Deok, Kim Misong, Ko Dohyeong, Chung Kyung-Sook, Hassan Ahmed H E, Lee Seung Hyeun, Lee Jae Yeol, Lee Kyung-Tae", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "32150979", "url": "https://glygen.org/publication/PubMed/32150979" } ] }, { "title": "Phosphorylated STAT3 (Tyr705) as a biomarker of response to pimozide treatment in triple-negative breast cancer.", 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"2020-05-14", "authors": "Qi Xin, Li Meng, Zhang Xiao-Min, Dai Xiu-Fen, Cui Jian, Li De-Hai, Gu Qian-Qun, Lv Zhi-Hua, Li Jing", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "32422984", "url": "https://glygen.org/publication/PubMed/32422984" } ] }, { "title": "CDYL2 Epigenetically Regulates MIR124 to Control NF-\u03baB/STAT3-Dependent Breast Cancer Cell Plasticity.", "journal": "iScience", "date": "2020-06-26", "authors": "Siouda Maha, Dujardin Audrey D, Barbollat-Boutrand Laetitia, Mendoza-Parra Marco A, Gibert Benjamin, Ouzounova Maria, Bouaoud Jebrane, Tonon Laurie, Robert Marie, Foy Jean-Philippe, Lavergne Vincent, Manie Serge N, Viari Alain, Puisieux Alain, Ichim Gabriel, Gronemeyer Hinrich, Saintigny Pierre, Mulligan Peter", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "32450513", "url": "https://glygen.org/publication/PubMed/32450513" } ] }, { "title": "Joint Reconstituted Signaling of the IL-6 Receptor via Extracellular Vesicles.", "journal": "Cells", "date": "2020-05-24", "authors": "Arnold Philipp, L\u00fcckst\u00e4dt Wiebke, Li Wenjia, Boll Inga, Lokau Juliane, Garbers Christoph, Lucius Ralph, Rose-John Stefan, Becker-Pauly Christoph", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "32456348", "url": "https://glygen.org/publication/PubMed/32456348" } ] }, { "title": "Regulation of signal transducer and activator of transcription 3 activation by dual-specificity phosphatase 3.", "journal": "BMB reports", "date": "2020", "authors": "Kim BR, Ha J, Kang E, Cho S", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" 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Zhou Ying", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "32491253", "url": "https://glygen.org/publication/PubMed/32491253" } ] }, { "title": "STAT3-mediated MLST8 gene expression regulates cap-dependent translation in cancer cells.", "journal": "Molecular oncology", "date": "2020", "authors": "Lee H, Chin H, Kim H, Jung H, Lee D", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "32495998", "url": "https://glygen.org/publication/PubMed/32495998" } ] }, { "title": "ACYP2 contributes to malignant progression of glioma through promoting Ca(2+) efflux and subsequently activating c-Myc and STAT3 signals.", "journal": "Journal of experimental & clinical cancer research : CR", "date": "2020", "authors": "Li M, Ruan B, Wei J, Yang Q, Chen M, Ji M, Hou P", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "32517717", "url": "https://glygen.org/publication/PubMed/32517717" } ] }, { "title": "IL-23R in laryngeal cancer: a cancer immunoediting process that facilitates tumor cell proliferation and results in cisplatin resistance.", "journal": "Carcinogenesis", "date": "2021-02-11", "authors": "Tao Ye, Shen Hailong, Liu Yujie, Li Guojun, Huang Zhigang, Liu Yehai", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "32526010", "url": "https://glygen.org/publication/PubMed/32526010" } ] }, { "title": "Interleukin-6 derived from cancer-associated fibroblasts attenuates the p53 response to doxorubicin in prostate cancer cells.", "journal": "Cell death discovery", "date": "2020", "authors": "Cheteh Emarndeena H, Sarne Victoria, Ceder Sophia, Bianchi Julie, Augsten Martin, Rundqvist Helene, Egevad Lars, \u00d6stman Arne, Wiman Klas G", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "32528731", "url": "https://glygen.org/publication/PubMed/32528731" } ] }, { "title": "STAT3 modulates reprogramming efficiency of human somatic cells; insights from autosomal dominant Hyper IgE syndrome caused by STAT3 mutations.", "journal": "Biology open", "date": "2020-09-10", "authors": "Yu Zhen, Dmitrieva Natalia I, Walts Avram D, Jin Hui, Liu Yangtengyu, Ping Xianfeng, Ferrante Elisa A, Qiu Lugui, Holland Steven M, Freeman Alexandra F, Chen Guibin, Boehm Manfred", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "32580970", "url": "https://glygen.org/publication/PubMed/32580970" } ] }, { "title": "miR-155-5p Implicates in the Pathogenesis of Renal Fibrosis via Targeting SOCS1 and SOCS6.", "journal": "Oxidative medicine and cellular longevity", "date": "2020", "authors": "Zhang W, Li X, Tang Y, Chen C, Jing R, Liu T", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "32587662", "url": "https://glygen.org/publication/PubMed/32587662" } ] }, { "title": "The crosstalk between AXL and YAP promotes tumor progression through STAT3 activation in head and neck squamous cell carcinoma.", "journal": "Cancer science", "date": "2020-09", "authors": "Li Jiayi, Shi Chaoji, Zhou Rong, Han Yong, Xu Shengming, Ma Hailong, Zhang Zhiyuan", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": 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Metastasis via STAT3 Signaling.", "journal": "Frontiers in oncology", "date": "2020", "authors": "Fu Yufei, Zheng Qi, Mao Yingying, Jiang Xiyi, Chen Xin, Liu Pei, Lv Bin, Huang Tuxiong, Yang Jiao, Cheng Yongran, Dai Xiaoyi, Dai Chunyan, Wang Xi, Yin Yifei, Song Tengjiao, Jin Weiyang, Zou Chang, Chen Tianhui, Fu Li, Chen Zhe", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "32766155", "url": "https://glygen.org/publication/PubMed/32766155" } ] }, { "title": "TgROP18 targets IL20RB for host-defense-related-STAT3 activation during Toxoplasma gondii infection.", "journal": "Parasites & vectors", "date": "2020-08-07", "authors": "Kong Ling, Jiang Dan, He Cheng, Xia Jing, Wei Haixia, Zhou Lijuan, Peng Hongjuan", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": 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Contreras Hector R, Castell\u00f3n Enrique A, Morote Juan, Paciucci Rosanna, Maitland Norman J, Bjartell Anders, Hellsten Rebecka", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "32811873", "url": "https://glygen.org/publication/PubMed/32811873" } ] }, { "title": "Senescence in Monocytes Facilitates Dengue Virus Infection by Increasing Infectivity.", "journal": "Frontiers in cellular and infection microbiology", "date": "2020", "authors": "Hsieh Tzu-Han, Tsai Tsung-Ting, Chen Chia-Ling, Shen Ting-Jing, Jhan Ming-Kai, Tseng Po-Chun, Lin Chiou-Feng", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "32850477", "url": "https://glygen.org/publication/PubMed/32850477" } ] }, { "title": "Biochanin A impedes STAT3 activation by upregulating p38\u03b4 MAPK phosphorylation in IL-6-stimulated macrophages.", "journal": "Inflammation research : official journal of the European Histamine Research Society ... [et al.]", "date": "2020-11", "authors": "Basu Anandita, Das Anindhya Sundar, Borah Pallab Kumar, Duary Raj Kumar, Mukhopadhyay Rupak", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "32852592", "url": "https://glygen.org/publication/PubMed/32852592" } ] }, { "title": "Cryptotanshinone chemosensitivity potentiation by TW-37 in human oral cancer cell lines by targeting STAT3-Mcl-1 signaling.", "journal": "Cancer cell international", "date": "2020", "authors": "Yang In-Hyoung, Hong Seung-Hyun, Jung Minjung, Ahn Chi-Hyun, Yoon Hye-Jung, Hong Seong Doo, Cho Sung-Dae, Shin Ji-Ae", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "32863764", "url": "https://glygen.org/publication/PubMed/32863764" } ] }, { "title": "10,11-dehydrocurvularin exerts antitumor effect against human breast cancer by suppressing STAT3 activation.", "journal": "Acta pharmacologica Sinica", "date": "2021-05", "authors": "Zhao Qun, Bi Yun, Zhong Jing, Li Xiang, Guo Jian, Liu Ying-Xiang, Pan Long-Rui, Tan Yan, Deng Zhang-Shuang, Yu Xian-Jun", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "32868906", "url": "https://glygen.org/publication/PubMed/32868906" } ] }, { "title": "Canine parvovirus induces G1/S cell cycle arrest that involves EGFR Tyr1086 phosphorylation.", "journal": "Virulence", "date": "2020-12", "authors": "Dai Xiaofeng, Zhang Xuanhao, Miao Yujie, Han Peiyu, Zhang Jianying", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "32877289", "url": "https://glygen.org/publication/PubMed/32877289" } ] }, { "title": "RBPJ contributes to the malignancy of glioblastoma and induction of proneural-mesenchymal transition via IL-6-STAT3 pathway.", "journal": "Cancer science", "date": "2020-11", "authors": "Zhang Guangtao, Tanaka Shingo, Jiapaer Shabierjiang, Sabit Hemragul, Tamai Sho, Kinoshita Masashi, Nakada Mitsutoshi", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "32885530", "url": "https://glygen.org/publication/PubMed/32885530" } ] }, { "title": "A role for annexin A2 in scaffolding the peroxiredoxin 2-STAT3 redox relay complex.", "journal": "Nature communications", "date": "2020", "authors": "Talwar D, Messens J, Dick TP", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "32908147", "url": "https://glygen.org/publication/PubMed/32908147" } ] }, { "title": "Dysregulation of MiR-30a-3p/Gastrin Enhances Tumor Growth and Invasion throughSTAT3/MMP11 Pathway in Gastric Cancer.", "journal": "OncoTargets and therapy", "date": "2020", "authors": "Liu Yan, Gao Meng, An Juan, Wang Xin, Jia Yan, Xu Junfeng, Zhu Jihai, Cui Jiantao, Li Wenmei, Xing Rui, Song Li, Liu Kejia, He Yuqi, Sheng Jianqiu, Qi Shengmei, Pan Yuanming, Lu Youyong", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "32922036", "url": "https://glygen.org/publication/PubMed/32922036" } ] }, { "title": "PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis.", "journal": "Nature cell biology", "date": "2020", "authors": "Hou J, Zhao R, Xia W, Chang CW, You Y, Hsu JM, Nie L, Chen Y, Wang YC, Liu C, Wang WJ, Wu Y, Ke B, Hsu JL, Huang K, Ye Z, Yang Y, Xia X, Li Y, Li CW, Shao B, Tainer JA, Hung 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"date": "2020", "authors": "Kunkl Martina, Amormino Carola, Frascolla Simone, Sambucci Manolo, De Bardi Marco, Caristi Silvana, Arcieri Stefano, Battistini Luca, Tuosto Loretta", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "33178223", "url": "https://glygen.org/publication/PubMed/33178223" } ] }, { "title": "Hypo-fractionation radiotherapy normalizes tumor vasculature in non-small cell lung cancer xenografts through the p-STAT3/HIF-1 alpha signaling pathway.", "journal": "Therapeutic advances in medical oncology", "date": "2020", "authors": "Tong Fan, Xiong Chun-Jin, Wei Chun-Hua, Wang Ye, Liang Zhi-Wen, Lu Hui, Pan Hui-Jiao, Dong Ji-Hua, Zheng Xue-Feng, Wu Gang, Dong Xiao-Rong", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "33193827", 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"https://oglcnac.org/atlas/detail/P40763" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis.", "journal": "Frontiers in immunology", "date": "2024", "authors": "Vang Shia, Helton Eric Scott, Guo Yiming, Burpee Bailey, Rose Elex, Easter Molly, Bollenbecker Seth, Hirsch Meghan June, Matthews Emma Lea, Jones Luke Isaac, Howze Patrick Henry, Rajasekaran Vasanthi, Denson Rebecca, Cochran Phillip, Attah Isaac Kwame, Olson Heather, Clair Geremy, Melkani Girish, Krick Stefanie, Barnes Jarrod Wesley", "evidence": [ { "database": "O-GlcNAc Database", "id": "P40763", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P40763" } ], "reference": [ { "type": "PubMed", "id": "38665916", "url": "https://glygen.org/publication/PubMed/38665916" } ] }, { "title": "Physical and functional interactions between STAT3 and ZIP kinase.", "journal": "International immunology", "date": "2005", "authors": "Sato N, Kawai T, Sugiyama K, Muromoto R, Imoto S, Sekine Y, Ishida M, Akira S, Matsuda T", "evidence": [ { "database": "UniProtKB", "id": "P40763", "url": "https://www.uniprot.org/uniprotkb/P40763" }, { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "16219639", "url": "https://glygen.org/publication/PubMed/16219639" } ] }, { "title": "Protein kinase C delta associates with and phosphorylates Stat3 in an interleukin-6-dependent manner.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Jain N, Zhang T, Kee WH, Li W, Cao X", "evidence": [ { "database": "iPTMnet", "id": "P40763-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763-1" } ], "reference": [ { "type": "PubMed", "id": "10446219", "url": "https://glygen.org/publication/PubMed/10446219" } ] }, { "title": "Serine phosphorylation and negative regulation of Stat3 by JNK.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Lim CP, Cao X", "evidence": [ { "database": "iPTMnet", "id": "P40763-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763-1" } ], "reference": [ { "type": "PubMed", "id": "10521505", "url": "https://glygen.org/publication/PubMed/10521505" } ] }, { "title": "Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3.", "journal": "The EMBO journal", "date": "2001", "authors": "Deb A, Zamanian-Daryoush M, Xu Z, Kadereit S, Williams BR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" }, { "database": "iPTMnet", "id": "P40763-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763-1" } ], "reference": [ { "type": "PubMed", "id": "11350938", "url": 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"evidence": [ { "database": "UniProtKB", "id": "P40763", "url": "https://www.uniprot.org/uniprotkb/P40763" }, { "database": "iPTMnet", "id": "P40763-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763-1" } ], "reference": [ { "type": "PubMed", "id": "12763138", "url": "https://glygen.org/publication/PubMed/12763138" } ] }, { "title": "Constitutively active Galpha16 stimulates STAT3 via a c-Src/JAK- and ERK-dependent mechanism.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Lo RK, Cheung H, Wong YH", "evidence": [ { "database": "iPTMnet", "id": "P40763-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763-1" } ], "reference": [ { "type": "PubMed", "id": "14551213", "url": "https://glygen.org/publication/PubMed/14551213" } ] }, { "title": "Phosphoproteome analysis of the human Chang liver cells using SCX and a complementary mass spectrometric strategy.", "journal": "Proteomics", "date": "2008", "authors": "Sui S, 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"iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "16740698", "url": "https://glygen.org/publication/PubMed/16740698" } ] }, { "title": "JNK and STAT3 signaling pathways converge on Akt-mediated phosphorylation of EZH2 in bronchial epithelial cells induced by arsenic.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2013", "authors": "Chen B, Liu J, Chang Q, Beezhold K, Lu Y, Chen F", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23255093", "url": "https://glygen.org/publication/PubMed/23255093" } ] }, { "title": "The role of the c-Jun N-terminal kinase 2-alpha-isoform in non-small cell lung carcinoma tumorigenesis.", "journal": "Oncogene", "date": "2011", "authors": "Nitta RT, Del Vecchio CA, Chu AH, Mitra SS, Godwin AK, Wong AJ", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "20871632", "url": "https://glygen.org/publication/PubMed/20871632" } ] }, { "title": "IRAK1 serves as a novel regulator essential for lipopolysaccharide-induced interleukin-10 gene expression.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Huang Y, Li T, Sane DC, Li L", "evidence": [ { "database": "UniProtKB", "id": "P40763", "url": "https://www.uniprot.org/uniprotkb/P40763" }, { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "15465816", "url": "https://glygen.org/publication/PubMed/15465816" } ] }, { "title": "Cyclin-dependent kinase 5 modulates STAT3 and androgen receptor activation through phosphorylation of Ser(7)(2)(7) on STAT3 in prostate cancer cells.", "journal": "American journal of physiology. 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with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer.", "journal": "Cancer research", "date": "2007", "authors": "Aziz MH, Manoharan HT, Church DR, Dreckschmidt NE, Zhong W, Oberley TD, Wilding G, Verma AK", "evidence": [ { "database": "UniProtKB", "id": "P40763", "url": "https://www.uniprot.org/uniprotkb/P40763" }, { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "17875724", "url": "https://glygen.org/publication/PubMed/17875724" } ] }, { "title": "The role of protein kinase C delta activation and STAT3 Ser727 phosphorylation in insulin-induced keratinocyte proliferation.", "journal": "Journal of cell science", "date": "2006", "authors": "Gartsbein M, Alt A, Hashimoto K, Nakajima K, Kuroki T, Tennenbaum T", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": 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"Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction.", "journal": "Genes & development", "date": "2004", "authors": "Ohkawara B, Shirakabe K, Hyodo-Miura J, Matsuo R, Ueno N, Matsumoto K, Shibuya H", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "15004007", "url": "https://glygen.org/publication/PubMed/15004007" } ] }, { "title": "STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2005", "authors": "Kojima H, Sasaki T, Ishitani T, Iemura S, Zhao H, Kaneko S, Kunimoto H, Natsume T, Matsumoto K, Nakajima K", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], 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"https://glygen.org/publication/PubMed/10537060" } ] }, { "title": "Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR.", "journal": "Current biology : CB", "date": "2000", "authors": "Yokogami K, Wakisaka S, Avruch J, Reeves SA", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "10660304", "url": "https://glygen.org/publication/PubMed/10660304" } ] }, { "title": "Interleukin-6-induced STAT3 transactivation and Ser727 phosphorylation involves Vav, Rac-1 and the kinase SEK-1/MKK-4 as signal transduction components.", "journal": "The Biochemical journal", "date": "2000", "authors": "Schuringa JJ, Jonk LJ, Dokter WH, Vellenga E, Kruijer W", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "10727406", "url": "https://glygen.org/publication/PubMed/10727406" } ] }, { "title": "Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6.", "journal": "Blood", "date": "2000", "authors": "Schuringa JJ, Wierenga AT, Kruijer W, Vellenga E", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "10845908", "url": "https://glygen.org/publication/PubMed/10845908" } ] }, { "title": "The Rac1/p38 mitogen-activated protein kinase pathway is required for interferon alpha-dependent transcriptional activation but not serine phosphorylation of Stat proteins.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Uddin S, Lekmine F, Sharma N, Majchrzak B, Mayer I, Young PR, Bokoch GM, Fish EN, Platanias LC", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "10878008", "url": "https://glygen.org/publication/PubMed/10878008" } ] }, { "title": "SCF and G-CSF lead to the synergistic induction of proliferation and gene expression through complementary signaling pathways.", "journal": "Blood", "date": "2000", "authors": "Duarte RF, Frank DA", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "11071637", "url": "https://glygen.org/publication/PubMed/11071637" } ] }, { "title": "A new expression cloning strategy for isolation of substrate-specific kinases by using phosphorylation site-specific antibody.", "journal": "Journal of immunological methods", "date": "2001", "authors": "Matsuo R, Ochiai W, Nakashima K, Taga T", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "11150545", "url": "https://glygen.org/publication/PubMed/11150545" } ] }, { "title": "Regulation of Stat3 activation by MEK kinase 1.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Lim CP, Cao X", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "11278353", "url": "https://glygen.org/publication/PubMed/11278353" } ] }, { "title": "Ser727-dependent transcriptional activation by association of p300 with STAT3 upon IL-6 stimulation.", "journal": "FEBS letters", "date": "2001", "authors": "Schuringa JJ, Schepers H, Vellenga E, Kruijer W", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "11322950", "url": "https://glygen.org/publication/PubMed/11322950" } ] }, { "title": "Sequential activation of Rac-1, SEK-1/MKK-4, and protein kinase Cdelta is required for interleukin-6-induced STAT3 Ser-727 phosphorylation and transactivation.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Schuringa JJ, Dekker LV, Vellenga E, Kruijer W", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "11335711", "url": "https://glygen.org/publication/PubMed/11335711" } ] }, { "title": "The YXXQ motif in gp 130 is crucial for STAT3 phosphorylation at Ser727 through an H7-sensitive kinase pathway.", "journal": "Oncogene", "date": "2001", "authors": "Abe K, Hirai M, Mizuno K, Higashi N, Sekimoto T, Miki T, Hirano T, Nakajima K", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "11429693", "url": "https://glygen.org/publication/PubMed/11429693" } ] }, { "title": "Rac1 mediates STAT3 activation by autocrine IL-6.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2001", "authors": "Faruqi TR, Gomez D, Bustelo XR, Bar-Sagi D, Reich NC", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "11470914", "url": "https://glygen.org/publication/PubMed/11470914" } ] }, { "title": "MSK1 and JNKs mediate phosphorylation of STAT3 in UVA-irradiated mouse epidermal JB6 cells.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Zhang Y, Liu G, Dong Z", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "11553624", "url": "https://glygen.org/publication/PubMed/11553624" } ] }, { "title": "No involvement of Erk/MAP kinases in IL-6-induced proliferation of a B cell hybridoma cell line.", "journal": "Osaka city medical journal", "date": "2001", "authors": "Abe K, Mizuno K, Nakajima K", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "11556393", "url": "https://glygen.org/publication/PubMed/11556393" } ] }, { "title": "Fibroblast growth factor-1 induced promatrilysin expression through the activation of extracellular-regulated kinases and STAT3.", "journal": "Neoplasia (New York, N.Y.)", "date": "2002", "authors": "Udayakumar TS, Stratton MS, Nagle RB, Bowden GT", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "11922392", "url": "https://glygen.org/publication/PubMed/11922392" } ] }, { "title": "Alcohol-induced c-Fos expression in the Edinger-Westphal nucleus: pharmacological and signal transduction mechanisms.", "journal": "The Journal of pharmacology and experimental therapeutics", "date": "2002", "authors": "Bachtell RK, Tsivkovskaia NO, Ryabinin AE", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "12130710", "url": "https://glygen.org/publication/PubMed/12130710" } ] }, { "title": "Expression of STAT3 and its phosphorylated forms in mantle cell lymphoma cell lines and tumours.", "journal": "The Journal of pathology", "date": "2003", "authors": "Lai R, Rassidakis GZ, Medeiros LJ, Leventaki V, Keating M, McDonnell TJ", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "12474230", "url": "https://glygen.org/publication/PubMed/12474230" } ] }, { "title": "Angiotensin II effects on STAT3 phosphorylation in cardiomyocytes: evidence for Erk-dependent Tyr705 dephosphorylation.", "journal": "Basic research in cardiology", "date": "2003", "authors": "Booz GW, Day JN, Baker KM", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "12494267", "url": "https://glygen.org/publication/PubMed/12494267" } ] }, { "title": "Ataxia telangiectasia mutated proteins, MAPKs, and RSK2 are involved in the phosphorylation of STAT3.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Zhang Y, Cho YY, Petersen BL, Bode AM, Zhu F, Dong Z", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "12562765", "url": "https://glygen.org/publication/PubMed/12562765" } ] }, { "title": "Interleukin-13 induction of 15-lipoxygenase gene expression requires p38 mitogen-activated protein kinase-mediated serine 727 phosphorylation of Stat1 and Stat3.", "journal": "Molecular and cellular biology", "date": "2003", "authors": "Xu B, Bhattacharjee A, Roy B, Xu HM, Anthony D, Frank DA, Feldman GM, Cathcart MK", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "12748293", "url": "https://glygen.org/publication/PubMed/12748293" } ] }, { "title": "BMPs signal alternately through a SMAD or FRAP-STAT pathway to regulate fate choice in CNS stem cells.", "journal": "The Journal of cell biology", "date": "2003", "authors": "Rajan P, Panchision DM, Newell LF, McKay RD", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "12796477", "url": "https://glygen.org/publication/PubMed/12796477" } ] }, { "title": "Pyk2 amplifies epidermal growth factor and c-Src-induced Stat3 activation.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Shi CS, Kehrl JH", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "14963038", "url": "https://glygen.org/publication/PubMed/14963038" } ] }, { "title": "Hepatocyte growth factor induces Mcl-1 in primary human hepatocytes and inhibits CD95-mediated apoptosis via Akt.", "journal": "Hepatology (Baltimore, Md.)", "date": "2004", "authors": "Schulze-Bergkamen H, Brenner D, Krueger A, Suess D, Fas SC, Frey CR, Dax A, Zink D, Buchler P, Muller M, Krammer PH", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "14999683", "url": "https://glygen.org/publication/PubMed/14999683" } ] }, { "title": "ERK1/2 contributes negative regulation to STAT3 activity in HSS-transfected HepG2 cells.", "journal": "Cell research", "date": "2004", "authors": "Tian ZJ, An W", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "15115615", "url": "https://glygen.org/publication/PubMed/15115615" } ] }, { "title": "Signal transducer and activator of transcription 3 activation by the delta-opioid receptor via Galpha14 involves multiple intermediates.", "journal": "Molecular pharmacology", "date": "2004", "authors": "Lo RK, Wong YH", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "15155836", "url": "https://glygen.org/publication/PubMed/15155836" } ] }, { "title": "The broad-range cyclin-dependent kinase inhibitor UCN-01 induces apoptosis in colon carcinoma cells through transcriptional suppression of the Bcl-x(L) protein.", "journal": "Oncogene", "date": "2005", "authors": "Bhonde MR, Hanski ML, Magrini R, Moorthy D, Muller A, Sausville EA, Kohno K, Wiegand P, Daniel PT, Zeitz M, Hanski C", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "15467762", "url": "https://glygen.org/publication/PubMed/15467762" } ] }, { "title": "Interleukin-12-induced interferon-gamma production by human peripheral blood T cells is regulated by mammalian target of rapamycin (mTOR).", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Kusaba H, Ghosh P, Derin R, Buchholz M, Sasaki C, Madara K, Longo DL", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "15522880", "url": "https://glygen.org/publication/PubMed/15522880" } ] }, { "title": "Tyrosine dephosphorylation of STAT3 in SARS coronavirus-infected Vero E6 cells.", "journal": "FEBS letters", "date": "2004-11-05", "authors": "Mizutani Tetsuya, Fukushi Shuetsu, Murakami Masaaki, Hirano Toshio, Saijo Masayuki, Kurane Ichiro, Morikawa Shigeru", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "15527783", "url": "https://glygen.org/publication/PubMed/15527783" } ] }, { "title": "ICAM-1 induction by TNFalpha and IL-6 is mediated by distinct pathways via Rac in endothelial cells.", "journal": "Journal of biomedical science", "date": "2005", "authors": "Wung B S, Ni C W, Wang D L", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "15864742", "url": "https://glygen.org/publication/PubMed/15864742" } ] }, { "title": "Proline-, glutamic acid-, and leucine-rich protein-1 is essential in growth factor regulation of signal transducers and activators of transcription 3 activation.", "journal": "Cancer Res.", "date": "2005", "authors": "Manavathi B, Nair SS, Wang RA, Kumar R, Vadlamudi RK", "evidence": [ { "database": "UniProtKB", "id": "P40763", "url": "https://www.uniprot.org/uniprotkb/P40763" }, { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "15994929", "url": "https://glygen.org/publication/PubMed/15994929" } ] }, { "title": "STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells.", "journal": "The Biochemical journal", "date": "2005", "authors": "Bhattacharya S, Ray RM, Johnson LR", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" }, { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "16048438", "url": "https://glygen.org/publication/PubMed/16048438" } ] }, { "title": "Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3.", "journal": "Oncogene", "date": "2006", "authors": "Kumar RN, Shore SK, Dhanasekaran N", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "16247467", "url": "https://glygen.org/publication/PubMed/16247467" } ] }, { "title": "Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer.", "journal": "British journal of cancer", "date": "2005", "authors": "Lin HJ, Hsieh FC, Song H, Lin J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "16288304", "url": "https://glygen.org/publication/PubMed/16288304" } ] }, { "title": "Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin.", "journal": "The Journal of cell biology", "date": "2006", "authors": "Ng DC, Lin BH, Lim CP, Huang G, Zhang T, Poli V, Cao X", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "16401721", "url": "https://glygen.org/publication/PubMed/16401721" } ] }, { "title": "STAT3 ser727 phosphorylation and its association with negative estrogen receptor status in breast infiltrating ductal carcinoma.", "journal": "International journal of cancer", "date": "2006", "authors": "Yeh YT, Ou-Yang F, Chen IF, Yang SF, Wang YY, Chuang HY, Su JH, Hou MF, Yuan SS", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "16425286", "url": "https://glygen.org/publication/PubMed/16425286" } ] }, { "title": "Luteolin promotes degradation in signal transducer and activator of transcription 3 in human hepatoma cells: an implication for the antitumor potential of flavonoids.", "journal": "Cancer research", "date": "2006", "authors": "Selvendiran K, Koga H, Ueno T, Yoshida T, Maeyama M, Torimura T, Yano H, Kojiro M, Sata M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "16651438", "url": "https://glygen.org/publication/PubMed/16651438" } ] }, { "title": "Heparin synergistically enhances interleukin-11 signaling through up-regulation of the MAPK pathway.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Rajgopal R, Butcher M, Weitz JI, Shaughnessy SG", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "16720575", "url": "https://glygen.org/publication/PubMed/16720575" } ] }, { "title": "The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells.", "journal": "The Journal of experimental medicine", "date": "2006", "authors": "Sumimoto H, Imabayashi F, Iwata T, Kawakami Y", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "16801397", "url": "https://glygen.org/publication/PubMed/16801397" } ] }, { "title": "BCR-ABL activates STAT3 via JAK and MEK pathways in human cells.", "journal": "British journal of haematology", "date": "2006", "authors": "Coppo P, Flamant S, De Mas V, Jarrier P, Guillier M, Bonnet ML, Lacout C, Guilhot F, Vainchenker W, Turhan AG", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "16846476", "url": "https://glygen.org/publication/PubMed/16846476" } ] }, { "title": "Role of CDK5 in neuroprotection from serum deprivation by mu-opioid receptor agonist.", "journal": "Experimental neurology", "date": "2006", "authors": "Wang Y, Xie WY, He Y, Wang M, Yang YR, Zhang Y, Yin DM, Jordan-Sciutto KL, Han JS, Wang Y", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "16879821", "url": "https://glygen.org/publication/PubMed/16879821" } ] }, { "title": "Monocyte 15-lipoxygenase expression is regulated by a novel cytosolic signaling complex with protein kinase C delta and tyrosine-phosphorylated Stat3.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2006", "authors": "Bhattacharjee A, Xu B, Frank DA, Feldman GM, Cathcart MK", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "16951338", "url": "https://glygen.org/publication/PubMed/16951338" } ] }, { "title": "Regulation of Stat3 transcriptional activity by the conserved LPMSP motif for OSM and IL-6 signaling.", "journal": "FEBS letters", "date": "2006", "authors": "Sun W, Snyder M, Levy DE, Zhang JJ", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "17027757", "url": "https://glygen.org/publication/PubMed/17027757" } ] }, { "title": "Deactivation of Akt and STAT3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, Atiprimod.", "journal": "Molecular cancer therapeutics", "date": "2007", "authors": "Choudhari SR, Khan MA, Harris G, Picker D, Jacob GS, Block T, Shailubhai K", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "17237271", "url": "https://glygen.org/publication/PubMed/17237271" } ] }, { "title": "STAT1 and STAT3 phosphorylation by porins are independent of JAKs but are dependent on MAPK pathway and plays a role in U937 cells production of interleukin-6.", "journal": "Cytokine", "date": "2006", "authors": "Galdiero M, Vitiello M, D'Isanto M, Raieta K, Galdiero E", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "17258468", "url": "https://glygen.org/publication/PubMed/17258468" } ] }, { "title": "Stat3 activation in human endometrial and cervical cancers.", "journal": "British journal of cancer", "date": "2007", "authors": "Chen CL, Hsieh FC, Lieblein JC, Brown J, Chan C, Wallace JA, Cheng G, Hall BM, Lin J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "17311011", "url": "https://glygen.org/publication/PubMed/17311011" } ] }, { "title": "Silibinin inhibits constitutive activation of Stat3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells.", "journal": "Carcinogenesis", "date": "2007", "authors": "Agarwal C, Tyagi A, Kaur M, Agarwal R", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "17341659", "url": "https://glygen.org/publication/PubMed/17341659" } ] }, { "title": "LIGHT, a member of the TNF superfamily, activates Stat3 mediated by NIK pathway.", "journal": "Biochemical and biophysical research communications", "date": "2007", "authors": "Nadiminty N, Chun JY, Hu Y, Dutt S, Lin X, Gao AC", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "17543278", "url": "https://glygen.org/publication/PubMed/17543278" } ] }, { "title": "Acute alcohol activates STAT3, AP-1, and Sp-1 transcription factors via the family of Src kinases to promote IL-10 production in human monocytes.", "journal": "Journal of leukocyte biology", "date": "2007", "authors": "Norkina O, Dolganiuc A, Shapiro T, Kodys K, Mandrekar P, Szabo G", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "17575268", "url": "https://glygen.org/publication/PubMed/17575268" } ] }, { "title": "Can the protective actions of JAK-STAT in the heart be exploited therapeutically? Parsing the regulation of interleukin-6-type cytokine signaling.", "journal": "Journal of cardiovascular pharmacology", "date": "2007", "authors": "Kurdi M, Booz GW", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "17703129", "url": "https://glygen.org/publication/PubMed/17703129" } ] }, { "title": "Responses of cancer cells with wild-type or tyrosine kinase domain-mutated epidermal growth factor receptor (EGFR) to EGFR-targeted therapy are linked to downregulation of hypoxia-inducible factor-1alpha.", "journal": "Molecular cancer", "date": "2007", "authors": "Lu Y, Liang K, Li X, Fan Z", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "17931419", "url": "https://glygen.org/publication/PubMed/17931419" } ] }, { "title": "Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Kim JH, Kim JE, Liu HY, Cao W, Chen J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "17993646", "url": "https://glygen.org/publication/PubMed/17993646" } ] }, { "title": "Physical and functional interactions between STAT3 and KAP1.", "journal": "Oncogene", "date": "2008", "authors": "Tsuruma R, Ohbayashi N, Kamitani S, Ikeda O, Sato N, Muromoto R, Sekine Y, Oritani K, Matsuda T", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "18037959", "url": "https://glygen.org/publication/PubMed/18037959" } ] }, { "title": "NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2008", "authors": "Selvendiran K, Bratasz A, Tong L, Ignarro LJ, Kuppusamy P", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "18196976", "url": "https://glygen.org/publication/PubMed/18196976" } ] }, { "title": "Transcriptional activity of the DeltaNp63 promoter is regulated by STAT3.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Chu WK, Dai PM, Li HL, Chen JK", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "18198175", "url": "https://glygen.org/publication/PubMed/18198175" } ] }, { "title": "Phosphorylation and nuclear translocation of STAT3 regulated by the Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma.", "journal": "International journal of molecular medicine", "date": "2008", "authors": "Liu YP, Tan YN, Wang ZL, Zeng L, Lu ZX, Li LL, Luo W, Tang M, Cao Y", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "18204781", "url": "https://glygen.org/publication/PubMed/18204781" } ] }, { "title": "Nogo-66 promotes the differentiation of neural progenitors into astroglial lineage cells through mTOR-STAT3 pathway.", "journal": "PloS one", "date": "2008", "authors": "Wang B, Xiao Z, Chen B, Han J, Gao Y, Zhang J, Zhao W, Wang X, Dai J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "18365011", "url": "https://glygen.org/publication/PubMed/18365011" } ] }, { "title": "Rapid activation of Stat3 and ERK1/2 by nicotine modulates cell proliferation in human bladder cancer cells.", "journal": "Toxicological sciences : an official journal of the Society of Toxicology", "date": "2008", "authors": "Chen RJ, Ho YS, Guo HR, Wang YJ", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "18448488", "url": "https://glygen.org/publication/PubMed/18448488" } ] }, { "title": "Green tea polyphenol epigallocatechin-3-gallate suppresses collagen production and proliferation in keloid fibroblasts via inhibition of the STAT3-signaling pathway.", "journal": "The Journal of investigative dermatology", "date": "2008", "authors": "Park G, Yoon BS, Moon JH, Kim B, Jun EK, Oh S, Kim H, Song HJ, Noh JY, Oh C, You S", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "18463684", "url": "https://glygen.org/publication/PubMed/18463684" } ] }, { "title": "Hoxb1 controls cell fate specification and proliferative capacity of neural stem and progenitor cells.", "journal": "Stem cells (Dayton, Ohio)", "date": "2008", "authors": "Gouti M, Gavalas A", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "18499896", "url": "https://glygen.org/publication/PubMed/18499896" } ] }, { "title": "Inhibition of STAT3 Tyr705 phosphorylation by Smad4 suppresses transforming growth factor beta-mediated invasion and metastasis in pancreatic cancer cells.", "journal": "Cancer research", "date": "2008", "authors": "Zhao S, Venkatasubbarao K, Lazor JW, Sperry J, Jin C, Cao L, Freeman JW", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "18519681", "url": "https://glygen.org/publication/PubMed/18519681" } ] }, { "title": "Purvalanol A induces apoptosis and downregulation of antiapoptotic proteins through abrogation of phosphorylation of JAK2/STAT3 and RNA polymerase II.", "journal": "Anti-cancer drugs", "date": "2008", "authors": "Iizuka D, Ogura A, Kuwabara M, Inanami O", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "18525315", "url": "https://glygen.org/publication/PubMed/18525315" } ] }, { "title": "Human parvovirus B19 NS1 protein modulates inflammatory signaling by activation of STAT3/PIAS3 in human endothelial cells.", "journal": "Journal of virology", "date": "2008", "authors": "Duechting A, Tschope C, Kaiser H, Lamkemeyer T, Tanaka N, Aberle S, Lang F, Torresi J, Kandolf R, Bock CT", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "18550668", "url": "https://glygen.org/publication/PubMed/18550668" } ] }, { "title": "Effects of P2Y1 receptor on glial fibrillary acidic protein and glial cell line-derived neurotrophic factor production of astrocytes under ischemic condition and the related signaling pathways.", "journal": "Neuroscience bulletin", "date": "2008", "authors": "Sun JJ, Liu Y, Ye ZR", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "18668152", "url": "https://glygen.org/publication/PubMed/18668152" } ] }, { "title": "Prostacyclin receptor-induced STAT3 phosphorylation in human erythroleukemia cells is mediated via Galpha(s) and Galpha(16) hybrid signaling.", "journal": "Cellular signalling", "date": "2008", "authors": "Lo RK, Liu AM, Wise H, Wong YH", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "18755267", "url": "https://glygen.org/publication/PubMed/18755267" } ] }, { "title": "Activation of signal transducer and activator of transcription 3 through a phosphomimetic serine 727 promotes prostate tumorigenesis independent of tyrosine 705 phosphorylation.", "journal": "Cancer research", "date": "2008", "authors": "Qin HR, Kim HJ, Kim JY, Hurt EM, Klarmann GJ, Kawasaki BT, Duhagon Serrat MA, Farrar WL", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "18829527", "url": "https://glygen.org/publication/PubMed/18829527" } ] }, { "title": "STAT3 can be activated through paracrine signaling in breast epithelial cells.", "journal": "BMC cancer", "date": "2008", "authors": "Lieblein JC, Ball S, Hutzen B, Sasser AK, Lin HJ, Huang TH, Hall BM, Lin J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "18939993", "url": "https://glygen.org/publication/PubMed/18939993" } ] }, { "title": "Myricetin directly targets JAK1 to inhibit cell transformation.", "journal": "Cancer letters", "date": "2009", "authors": "Kumamoto T, Fujii M, Hou DX", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "18995957", "url": "https://glygen.org/publication/PubMed/18995957" } ] }, { "title": "HDAC3 influences phosphorylation of STAT3 at serine 727 by interacting with PP2A.", "journal": "Biochemical and biophysical research communications", "date": "2009", "authors": "Togi S, Kamitani S, Kawakami S, Ikeda O, Muromoto R, Nanbo A, Matsuda T", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "19121623", "url": "https://glygen.org/publication/PubMed/19121623" } ] }, { "title": "Ha-ras oncogene-induced Stat3 phosphorylation enhances oncogenicity of the cell.", "journal": "DNA and cell biology", "date": "2009", "authors": "Yeh HH, Giri R, Chang TY, Chou CY, Su WC, Liu HS", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "19182994", "url": "https://glygen.org/publication/PubMed/19182994" } ] }, { "title": "Caveolin-2 regulation of STAT3 transcriptional activation in response to insulin.", "journal": "Biochimica et biophysica acta", "date": "2009", "authors": "Kwon H, Jeong K, Hwang EM, Park JY, Hong SG, Choi WS, Pak Y", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "19427337", "url": "https://glygen.org/publication/PubMed/19427337" } ] }, { "title": "NADPH oxidase and ERK1/2 are involved in cadmium induced-STAT3 activation in HepG2 cells.", "journal": "Toxicology letters", "date": "2009", "authors": "Souza V, Escobar Mdel C, Bucio L, Hernandez E, Gomez-Quiroz LE, Gutierrez Ruiz MC", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "19429262", "url": "https://glygen.org/publication/PubMed/19429262" } ] }, { "title": "Avicin D: a protein reactive plant isoprenoid dephosphorylates Stat 3 by regulating both kinase and phosphatase activities.", "journal": "PloS one", "date": "2009", "authors": "Haridas V, Nishimura G, Xu ZX, Connolly F, Hanausek M, Walaszek Z, Zoltaszek R, Gutterman JU", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "19440292", "url": "https://glygen.org/publication/PubMed/19440292" } ] }, { "title": "[Effects of cyclic mechanical stretch on the activity of STAT3 in human bronchial epithelial cell (16HBEC)].", "journal": "Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition", "date": "2009", "authors": "Ning YY, Han SX, Wang T, Xu D, Wen FQ", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "19764570", "url": "https://glygen.org/publication/PubMed/19764570" } ] }, { "title": "Signal transducer and activator of transcription 3 (STAT3) mediates amino acid inhibition of insulin signaling through serine 727 phosphorylation.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Kim JH, Yoon MS, Chen J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "19875458", "url": "https://glygen.org/publication/PubMed/19875458" } ] }, { "title": "Extracellular Signal-regulated Kinase Activation Is Required for Serine 727 Phosphorylation of STAT3 in Schwann Cells in vitro and in vivo.", "journal": "The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology", "date": "2009", "authors": "Lee HK, Jung J, Lee SH, Seo SY, Suh DJ, Park HT", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "19885032", "url": "https://glygen.org/publication/PubMed/19885032" } ] }, { "title": "A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3.", "journal": "The Journal of experimental medicine", "date": "2009", "authors": "Yamamoto M, Standley DM, Takashima S, Saiga H, Okuyama M, Kayama H, Kubo E, Ito H, Takaura M, Matsuda T, Soldati-Favre D, Takeda K", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "19901082", "url": "https://glygen.org/publication/PubMed/19901082" } ] }, { "title": "STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells.", "journal": "Blood", "date": "2010", "authors": "Hazan-Halevy I, Harris D, Liu Z, Liu J, Li P, Chen X, Shanker S, Ferrajoli A, Keating MJ, Estrov Z", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "20154216", "url": "https://glygen.org/publication/PubMed/20154216" } ] }, { "title": "Safe and targeted anticancer efficacy of a novel class of antioxidant-conjugated difluorodiarylidenyl piperidones: differential cytotoxicity in healthy and cancer cells.", "journal": "Free radical biology & medicine", "date": "2010", "authors": "Selvendiran K, Ahmed S, Dayton A, Kuppusamy ML, Tazi M, Bratasz A, Tong L, Rivera BK, Kalai T, Hideg K, Kuppusamy P", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "20156552", "url": "https://glygen.org/publication/PubMed/20156552" } ] }, { "title": "Protein kinase Cvarepsilon mediates Stat3Ser727 phosphorylation, Stat3-regulated gene expression, and cell invasion in various human cancer cell lines through integration with MAPK cascade (RAF-1, MEK1/2, and ERK1/2).", "journal": "Oncogene", "date": "2010", "authors": "Aziz MH, Hafeez BB, Sand JM, Pierce DB, Aziz SW, Dreckschmidt NE, Verma AK", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "20228845", "url": "https://glygen.org/publication/PubMed/20228845" } ] }, { "title": "STAT3 is essential for the maintenance of neurosphere-initiating tumor cells in patients with glioblastomas: a potential for targeted therapy?", "journal": "International journal of cancer", "date": "2011", "authors": "Villalva C, Martin-Lanneree S, Cortes U, Dkhissi F, Wager M, Le Corf A, Tourani JM, Dusanter-Fourt I, Turhan AG, Karayan-Tapon L", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "20473906", "url": "https://glygen.org/publication/PubMed/20473906" } ] }, { "title": "The cdk5 kinase regulates the STAT3 transcription factor to prevent DNA damage upon topoisomerase I inhibition.", "journal": "The Journal of biological chemistry", "date": "2010", "authors": "Courapied S, Sellier H, de Carne Trecesson S, Vigneron A, Bernard AC, Gamelin E, Barre B, Coqueret O", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "20516069", "url": "https://glygen.org/publication/PubMed/20516069" } ] }, { "title": "Stat3 activates the receptor tyrosine kinase like orphan receptor-1 gene in chronic lymphocytic leukemia cells.", "journal": "PloS one", "date": "2010", "authors": "Li P, Harris D, Liu Z, Liu J, Keating M, Estrov Z", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "20686606", "url": "https://glygen.org/publication/PubMed/20686606" } ] }, { "title": "A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells.", "journal": "Molecular cancer", "date": "2010", "authors": "Lin L, Deangelis S, Foust E, Fuchs J, Li C, Li PK, Schwartz EB, Lesinski GB, Benson D, Lu J, Hoyt D, Lin J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "20712901", "url": "https://glygen.org/publication/PubMed/20712901" } ] }, { "title": "A therapeutic approach to nasopharyngeal carcinomas by DNAzymes targeting EBV LMP-1 gene.", "journal": "Molecules (Basel, Switzerland)", "date": "2010", "authors": "Yang L, Lu Z, Ma X, Cao Y, Sun LQ", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "20877211", "url": "https://glygen.org/publication/PubMed/20877211" } ] }, { "title": "Aberrant expression and constitutive activation of STAT3 in cervical carcinogenesis: implications in high-risk human papillomavirus infection.", "journal": "Molecular cancer", "date": "2010", "authors": "Shukla S, Shishodia G, Mahata S, Hedau S, Pandey A, Bhambhani S, Batra S, Basir SF, Das BC, Bharti AC", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "20977777", "url": "https://glygen.org/publication/PubMed/20977777" } ] }, { "title": "HDL and sphingosine-1-phosphate activate stat3 in prostate cancer DU145 cells via ERK1/2 and S1P receptors, and promote cell migration and invasion.", "journal": "The Prostate", "date": "2011", "authors": "Sekine Y, Suzuki K, Remaley AT", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "20979115", "url": "https://glygen.org/publication/PubMed/20979115" } ] }, { "title": "Inhibition of constitutive activation of STAT3 by curcurbitacin-I (JSI-124) sensitized human B-leukemia cells to apoptosis.", "journal": "Molecular cancer therapeutics", "date": "2010", "authors": "Ishdorj G, Johnston JB, Gibson SB", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21159613", "url": "https://glygen.org/publication/PubMed/21159613" } ] }, { "title": "A helminth immunomodulator exploits host signaling events to regulate cytokine production in macrophages.", "journal": "PLoS pathogens", "date": "2011", "authors": "Klotz C, Ziegler T, Figueiredo AS, Rausch S, Hepworth MR, Obsivac N, Sers C, Lang R, Hammerstein P, Lucius R, Hartmann S", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21253577", "url": "https://glygen.org/publication/PubMed/21253577" } ] }, { "title": "CD5 promotes IL-10 production in chronic lymphocytic leukemia B cells through STAT3 and NFAT2 activation.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2011", "authors": "Garaud S, Morva A, Lemoine S, Hillion S, Bordron A, Pers JO, Berthou C, Mageed RA, Renaudineau Y, Youinou P", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21398617", "url": "https://glygen.org/publication/PubMed/21398617" } ] }, { "title": "Gambogic acid inhibits STAT3 phosphorylation through activation of protein tyrosine phosphatase SHP-1: potential role in proliferation and apoptosis.", "journal": "Cancer prevention research (Philadelphia, Pa.)", "date": "2011", "authors": "Prasad S, Pandey MK, Yadav VR, Aggarwal BB", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21490133", "url": "https://glygen.org/publication/PubMed/21490133" } ] }, { "title": "Inhibition of Stat3 activation by sanguinarine suppresses prostate cancer cell growth and invasion.", "journal": "The Prostate", "date": "2012", "authors": "Sun M, Liu C, Nadiminty N, Lou W, Zhu Y, Yang J, Evans CP, Zhou Q, Gao AC", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21538419", "url": "https://glygen.org/publication/PubMed/21538419" } ] }, { "title": "The STAT3 beacon: IL-6 recurrently activates STAT 3 from endosomal structures.", "journal": "Experimental cell research", "date": "2011", "authors": "German CL, Sauer BM, Howe CL", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21619877", "url": "https://glygen.org/publication/PubMed/21619877" } ] }, { "title": "Two naturally occurring terpenes, dehydrocostuslactone and costunolide, decrease intracellular GSH content and inhibit STAT3 activation.", "journal": "PloS one", "date": "2011", "authors": "Butturini E, Cavalieri E, de Prati AC, Darra E, Rigo A, Shoji K, Murayama N, Yamazaki H, Watanabe Y, Suzuki H, Mariotto S", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21625597", "url": "https://glygen.org/publication/PubMed/21625597" } ] }, { "title": "Deactivation of signal transducer and activator of transcription 3 reverses chemotherapeutics resistance of leukemia cells via down-regulating P-gp.", "journal": "PloS one", "date": "2011", "authors": "Zhang X, Xiao W, Wang L, Tian Z, Zhang J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21677772", "url": "https://glygen.org/publication/PubMed/21677772" } ] }, { "title": "Cucurbitacin-I (JSI-124) activates the JNK/c-Jun signaling pathway independent of apoptosis and cell cycle arrest in B leukemic cells.", "journal": "BMC cancer", "date": "2011", "authors": "Ishdorj G, Johnston JB, Gibson SB", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21702955", "url": "https://glygen.org/publication/PubMed/21702955" } ] }, { "title": "Phosphorylation of Stats at Ser727 in renal proximal tubular epithelial cells exposed to cadmium.", "journal": "Environmental toxicology and pharmacology", "date": "2007", "authors": "Nakagawa J, Nishitai G, Inageda K, Matsuoka M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21783819", "url": "https://glygen.org/publication/PubMed/21783819" } ] }, { "title": "Heteroarylketones inhibit astroglial interleukin-6 expression via a STAT3/NF-kappaB signaling pathway.", "journal": "Journal of neuroinflammation", "date": "2011", "authors": "Schulz I, Engel C, Niestroj AJ, Zeitschel U, Menge K, Kehlen A, Meyer A, Rossner S, Demuth HU", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21801384", "url": "https://glygen.org/publication/PubMed/21801384" } ] }, { "title": "Hck is a key regulator of gene expression in alternatively activated human monocytes.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Bhattacharjee A, Pal S, Feldman GM, Cathcart MK", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21878628", "url": "https://glygen.org/publication/PubMed/21878628" } ] }, { "title": "Adenovirus-mediated delivery of bFGF small interfering RNA reduces STAT3 phosphorylation and induces the depolarization of mitochondria and apoptosis in glioma cells U251.", "journal": "Journal of experimental & clinical cancer research : CR", "date": "2011-09-09", "authors": "Liu Jun, Xu Xinnv, Feng Xuequan, Zhang Biao, Wang Jinhuan", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21906308", "url": "https://glygen.org/publication/PubMed/21906308" } ] }, { "title": "Jak2-Independent Activation of Stat3 by Intracellular Angiotensin II in Human Mesangial Cells.", "journal": "Journal of signal transduction", "date": "2011", "authors": "Singh R", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21915376", "url": "https://glygen.org/publication/PubMed/21915376" } ] }, { "title": "Interleukin-6 autocrine signaling mediates melatonin MT(1/2) receptor-induced STAT3 Tyr(705) phosphorylation.", "journal": "Journal of pineal research", "date": "2012", "authors": "Lau WW, Ng JK, Lee MM, Chan AS, Wong YH", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "21954831", "url": "https://glygen.org/publication/PubMed/21954831" } ] }, { "title": "Phosphorylation of STAT3 in head and neck cancer requires p38 MAPKinase, whereas phosphorylation of STAT1 occurs via a different signaling pathway.", "journal": "Anticancer research", "date": "2011", "authors": "Riebe C, Pries R, Schroeder KN, Wollenberg B", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22110204", "url": "https://glygen.org/publication/PubMed/22110204" } ] }, { "title": "Calyculin A reveals serine/threonine phosphatase protein phosphatase 1 as a regulatory nodal point in canonical signal transducer and activator of transcription 3 signaling of human microvascular endothelial cells.", "journal": "Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research", "date": "2012", "authors": "Zgheib C, Zouein FA, Chidiac R, Kurdi M, Booz GW", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22142222", "url": "https://glygen.org/publication/PubMed/22142222" } ] }, { "title": "The FGFR4-G388R polymorphism promotes mitochondrial STAT3 serine phosphorylation to facilitate pituitary growth hormone cell tumorigenesis.", "journal": "PLoS genetics", "date": "2011", "authors": "Tateno T, Asa SL, Zheng L, Mayr T, Ullrich A, Ezzat S", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22174695", "url": "https://glygen.org/publication/PubMed/22174695" } ] }, { "title": "The peroxisome proliferator-activated receptor (PPAR) beta/delta agonist GW501516 inhibits IL-6-induced signal transducer and activator of transcription 3 (STAT3) activation and insulin resistance in human liver cells.", "journal": "Diabetologia", "date": "2012", "authors": "Serrano-Marco L, Barroso E, El Kochairi I, Palomer X, Michalik L, Wahli W, Vazquez-Carrera M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22179221", "url": "https://glygen.org/publication/PubMed/22179221" } ] }, { "title": "14-3-3zeta interacts with stat3 and regulates its constitutive activation in multiple myeloma cells.", "journal": "PloS one", "date": "2012", "authors": "Zhang J, Chen F, Li W, Xiong Q, Yang M, Zheng P, Li C, Pei J, Ge F", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22279540", "url": "https://glygen.org/publication/PubMed/22279540" } ] }, { "title": "Diindolylmethane suppresses ovarian cancer growth and potentiates the effect of cisplatin in tumor mouse model by targeting signal transducer and activator of transcription 3 (STAT3).", "journal": "BMC medicine", "date": "2012", "authors": "Kandala PK, Srivastava SK", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22280969", "url": "https://glygen.org/publication/PubMed/22280969" } ] }, { "title": "Role of MMP-2 in the regulation of IL-6/Stat3 survival signaling via interaction with alpha5beta1 integrin in glioma.", "journal": "Oncogene", "date": "2013", "authors": "Kesanakurti D, Chetty C, Dinh DH, Gujrati M, Rao JS", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22349830", "url": "https://glygen.org/publication/PubMed/22349830" } ] }, { "title": "GRIM-19-mediated translocation of STAT3 to mitochondria is necessary for TNF-induced necroptosis.", "journal": "Journal of cell science", "date": "2012", "authors": "Shulga N, Pastorino JG", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22393233", "url": "https://glygen.org/publication/PubMed/22393233" } ] }, { "title": "Role and regulation of STAT3 phosphorylation at Ser727 in melanocytes and melanoma cells.", "journal": "The Journal of investigative dermatology", "date": "2012", "authors": "Sakaguchi M, Oka M, Iwasaki T, Fukami Y, Nishigori C", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22418867", "url": "https://glygen.org/publication/PubMed/22418867" } ] }, { "title": "STAT3 mutations correlated with hyper-IgE syndrome lead to blockage of IL-6/STAT3 signalling pathway.", "journal": "Journal of biosciences", "date": "2012", "authors": "He J, Shi J, Xu X, Zhang W, Wang Y, Chen X, Du Y, Zhu N, Zhang J, Wang Q, Yang J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22581330", "url": "https://glygen.org/publication/PubMed/22581330" } ] }, { "title": "Targeting of Rac GTPases blocks the spread of intact human breast cancer.", "journal": "Oncotarget", "date": "2012", "authors": "Katz E, Sims AH, Sproul D, Caldwell H, Dixon MJ, Meehan RR, Harrison DJ", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": 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"iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22791907", "url": "https://glygen.org/publication/PubMed/22791907" } ] }, { "title": "Inhibition of STAT3 reverses drug resistance acquired in temozolomide-resistant human glioma cells.", "journal": "Oncology letters", "date": "2011", "authors": "Lee ES, Ko KK, Joe YA, Kang SG, Hong YK", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22870139", "url": "https://glygen.org/publication/PubMed/22870139" } ] }, { "title": "Acyloxy nitroso compounds inhibit LIF signaling in endothelial cells and cardiac myocytes: evidence that STAT3 signaling is redox-sensitive.", "journal": "PloS one", "date": "2012", "authors": "Zgheib C, Kurdi M, Zouein FA, Gunter BW, Stanley BA, Zgheib J, Romero DG, King SB, Paolocci N, Booz GW", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22905257", "url": "https://glygen.org/publication/PubMed/22905257" } ] }, { "title": "Inhibition of STAT signalling in bladder cancer by diindolylmethane: relevance to cell adhesion, migration and proliferation.", "journal": "Current cancer drug targets", "date": "2013", "authors": "Sun Y, Cheng MK, Griffiths TR, Mellon JK, Kai B, Kriajevska M, Manson MM", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22920439", "url": "https://glygen.org/publication/PubMed/22920439" } ] }, { "title": "STAT3 signal transduction through interleukin-22 in oral squamous cell carcinoma.", "journal": "International journal of oncology", "date": "2012", "authors": "Naher L, Kiyoshima T, Kobayashi I, Wada H, Nagata K, Fujiwara H, Ookuma YF, Ozeki S, Nakamura S, Sakai H", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22922995", "url": "https://glygen.org/publication/PubMed/22922995" } ] }, { "title": "Calpain/SHP-1 interaction by honokiol dampening peritoneal dissemination of gastric cancer in nu/nu mice.", "journal": "PloS one", "date": "2012", "authors": "Liu SH, Wang KB, Lan KH, Lee WJ, Pan HC, Wu SM, Peng YC, Chen YC, Shen CC, Cheng HC, Liao KK, Sheu ML", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "22937084", "url": "https://glygen.org/publication/PubMed/22937084" } ] }, { "title": "CCR1-mediated STAT3 tyrosine phosphorylation and CXCL8 expression in THP-1 macrophage-like cells involve pertussis toxin-insensitive Galpha(14/16) signaling and IL-6 release.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2012", "authors": "Lee MM, Chui RK, Tam IY, Lau AH, Wong YH", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23125416", "url": "https://glygen.org/publication/PubMed/23125416" } ] }, { "title": "Protective role of STAT3 in NMDA and glutamate-induced neuronal death: negative regulatory effect of SOCS3.", "journal": "PloS one", "date": "2012", "authors": "Park KW, Nozell SE, Benveniste EN", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23226414", "url": "https://glygen.org/publication/PubMed/23226414" } ] }, { "title": "p42/p44 MAPK-mediated Stat3Ser727 phosphorylation is required for progestin-induced full activation of Stat3 and breast cancer growth.", "journal": "Endocrine-related cancer", "date": "2013", "authors": "Tkach M, Rosemblit C, Rivas MA, Proietti CJ, Diaz Flaque MC, Mercogliano MF, Beguelin W, Maronna E, Guzman P, Gercovich FG, Deza EG, Elizalde PV, Schillaci R", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23329648", "url": "https://glygen.org/publication/PubMed/23329648" } ] }, { "title": "Gadd45a suppresses tumor angiogenesis via inhibition of the mTOR/STAT3 protein pathway.", "journal": "The Journal of biological chemistry", "date": "2013", "authors": "Yang F, Zhang W, Li D, Zhan Q", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23329839", "url": "https://glygen.org/publication/PubMed/23329839" } ] }, { "title": "CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response.", "journal": "Immunity", "date": "2013", "authors": "Bancerek J, Poss ZC, Steinparzer I, Sedlyarov V, Pfaffenwimmer T, Mikulic I, Dolken L, Strobl B, Muller M, Taatjes DJ, Kovarik P", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23352233", "url": "https://glygen.org/publication/PubMed/23352233" } ] }, { "title": "IL-22 is related to development of human colon cancer by activation of STAT3.", "journal": "BMC cancer", "date": "2013", "authors": "Jiang R, Wang H, Deng L, Hou J, Shi R, Yao M, Gao Y, Yao A, Wang X, Yu L, Sun B", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23379788", "url": "https://glygen.org/publication/PubMed/23379788" } ] }, { "title": "Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor.", "journal": "Oncogene", "date": "2014", "authors": "Becker TM, Boyd SC, Mijatov B, Gowrishankar K, Snoyman S, Pupo GM, Scolyer RA, Mann GJ, Kefford RF, Zhang XD, Rizos H", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" }, { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23455323", "url": "https://glygen.org/publication/PubMed/23455323" } ] }, { "title": "Studies of Jak/STAT3 expression and signalling in psoriasis identifies STAT3-Ser727 phosphorylation as a modulator of transcriptional activity.", "journal": "Experimental dermatology", "date": "2013", "authors": "Andres RM, Hald A, Johansen C, Kragballe K, Iversen L", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23614738", "url": "https://glygen.org/publication/PubMed/23614738" } ] }, { "title": "Simvastatin inhibits renal cancer cell growth and metastasis via AKT/mTOR, ERK and JAK2/STAT3 pathway.", "journal": "PloS one", "date": "2013", "authors": "Fang Z, Tang Y, Fang J, Zhou Z, Xing Z, Guo Z, Guo X, Wang W, Jiao W, Xu Z, Liu Z", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23690956", "url": "https://glygen.org/publication/PubMed/23690956" } ] }, { "title": "IL-26 promotes the proliferation and survival of human gastric cancer cells by regulating the balance of STAT1 and STAT3 activation.", "journal": "PloS one", "date": "2013", "authors": "You W, Tang Q, Zhang C, Wu J, Gu C, Wu Z, Li X", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23704922", "url": "https://glygen.org/publication/PubMed/23704922" } ] }, { "title": "Kaposi's sarcoma-associated herpesvirus kaposin B induces unique monophosphorylation of STAT3 at serine 727 and MK2-mediated inactivation of the STAT3 transcriptional repressor TRIM28.", "journal": "Journal of virology", "date": "2013", "authors": "King CA", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23740979", "url": "https://glygen.org/publication/PubMed/23740979" } ] }, { "title": "Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells.", "journal": "The Biochemical journal", "date": "2013", "authors": "Wiejak J, Dunlop J, Mackay SP, Yarwood SJ", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23782265", "url": "https://glygen.org/publication/PubMed/23782265" } ] }, { "title": "STAT3 integrates cytokine and neurotrophin signals to promote sympathetic axon regeneration.", "journal": "Molecular and cellular neurosciences", "date": "2013", "authors": "Pellegrino MJ, Habecker BA", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "23831387", "url": "https://glygen.org/publication/PubMed/23831387" } ] }, { "title": "Early methyl donor deficiency may induce persistent brain defects by reducing Stat3 signaling targeted by miR-124.", "journal": "Cell death & disease", "date": "2013", "authors": "Kerek R, Geoffroy A, Bison A, Martin N, Akchiche N, Pourie G, Helle D, Gueant JL, Bossenmeyer-Pourie C, Daval JL", "evidence": [ 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"date": "2013", "authors": "Manni S, Brancalion A, Mandato E, Tubi LQ, Colpo A, Pizzi M, Cappellesso R, Zaffino F, Di Maggio SA, Cabrelle A, Marino F, Zambello R, Trentin L, Adami F, Gurrieri C, Semenzato G, Piazza F", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24086494", "url": "https://glygen.org/publication/PubMed/24086494" } ] }, { "title": "Sorafenib sensitizes solid tumors to Apo2L/TRAIL and Apo2L/TRAIL receptor agonist antibodies by the Jak2-Stat3-Mcl1 axis.", "journal": "PloS one", "date": "2013", "authors": "Abdulghani J, Allen JE, Dicker DT, Liu YY, Goldenberg D, Smith CD, Humphreys R, El-Deiry WS", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24086526", "url": "https://glygen.org/publication/PubMed/24086526" } ] }, { "title": "Resveratrol suppresses cell proliferation via inhibition of STAT3 phosphorylation and Mcl-1 and cIAP-2 expression in HTLV-1-infected T cells.", "journal": "Leukemia research", "date": "2013", "authors": "Suzuki Y, Ito S, Sasaki R, Asahi M, Ishida Y", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24090995", "url": "https://glygen.org/publication/PubMed/24090995" } ] }, { "title": "Inhibition of protein kinase CK2 with the clinical-grade small ATP-competitive compound CX-4945 or by RNA interference unveils its role in acute myeloid leukemia cell survival, p53-dependent apoptosis and daunorubicin-induced cytotoxicity.", "journal": "Journal of hematology & oncology", "date": "2013", "authors": "Quotti Tubi L, Gurrieri C, Brancalion A, Bonaldi L, Bertorelle R, Manni S, Pavan L, Lessi F, Zambello R, Trentin L, Adami F, Ruzzene M, Pinna LA, Semenzato G, Piazza F", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24283803", "url": "https://glygen.org/publication/PubMed/24283803" } ] }, { "title": "Intranuclear crosstalk between extracellular regulated kinase1/2 and signal transducer and activator of transcription 3 regulates JEG-3 choriocarcinoma cell invasion and proliferation.", "journal": "TheScientificWorldJournal", "date": "2013", "authors": "Morales-Prieto DM, Ospina-Prieto S, Chaiwangyen W, Weber M, Holters S, Schleussner E, Fitzgerald JS, Markert UR", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24288470", "url": "https://glygen.org/publication/PubMed/24288470" } ] }, { "title": "The MEK-ERK pathway is necessary for serine phosphorylation of mitochondrial STAT3 and Ras-mediated transformation.", "journal": "PloS one", "date": "2013", "authors": "Gough DJ, Koetz L, Levy DE", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24312439", "url": "https://glygen.org/publication/PubMed/24312439" } ] }, { "title": "Everolimus-induced human keratinocytes toxicity is mediated by STAT3 inhibition.", "journal": "Journal of experimental & clinical cancer research : CR", "date": "2013", "authors": "Yamamoto K, Uda A, Mukai A, Yamashita K, Kume M, Makimoto H, Bito T, Nishigori C, Hirano T, Hirai M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24423131", "url": "https://glygen.org/publication/PubMed/24423131" } ] }, { "title": "Boswellic acids reduce Th17 differentiation via blockade of IL-1beta-mediated IRAK1 signaling.", 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mechanical ventilation prevents ventilation-induced diaphragm dysfunction.", "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology", "date": "2014", "authors": "Smith IJ, Godinez GL, Singh BK, McCaughey KM, Alcantara RR, Gururaja T, Ho MS, Nguyen HN, Friera AM, White KA, McLaughlin JR, Hansen D, Romero JM, Baltgalvis KA, Claypool MD, Li W, Lang W, Yam GC, Gelman MS, Ding R, Yung SL, Creger DP, Chen Y, Singh R, Smuder AJ, Wiggs MP, Kwon OS, Sollanek KJ, Powers SK, Masuda ES, Taylor VC, Payan DG, Kinoshita T, Kinsella TM", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24671708", "url": "https://glygen.org/publication/PubMed/24671708" } ] }, { "title": "IL-32alpha down-regulates beta2 integrin (CD18) expression by suppressing PU.1 expression in myeloid cells.", "journal": "Cellular signalling", "date": "2014", "authors": "Kang JW, Park YS, Kim MS, Lee DH, Bak Y, Ham SY, Song YS, Hong JT, Yoon DY", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24703937", "url": "https://glygen.org/publication/PubMed/24703937" } ] }, { "title": "Reduced phosphorylation of Stat3 at Ser-727 mediated by casein kinase 2 - protein phosphatase 2A enhances Stat3 Tyr-705 induced tumorigenic potential of glioma cells.", "journal": "Cellular signalling", "date": "2014", "authors": "Mandal T, Bhowmik A, Chatterjee A, Chatterjee U, Chatterjee S, Ghosh MK", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24726840", "url": "https://glygen.org/publication/PubMed/24726840" } ] }, { "title": "Increased STAT1 signaling in endocrine-resistant breast cancer.", "journal": "PloS one", "date": "2014", "authors": "Huang R, Faratian D, Sims AH, Wilson D, Thomas JS, Harrison DJ, Langdon SP", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24728078", "url": "https://glygen.org/publication/PubMed/24728078" } ] }, { "title": "Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer.", "journal": "Molecular systems biology", "date": "2014", "authors": "Yang L, Moss T, Mangala LS, Marini J, Zhao H, Wahlig S, Armaiz-Pena G, Jiang D, Achreja A, Win J, Roopaimoole R, Rodriguez-Aguayo C, Mercado-Uribe I, Lopez-Berestein G, Liu J, Tsukamoto T, Sood AK, Ram PT, Nagrath D", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24799285", "url": "https://glygen.org/publication/PubMed/24799285" } ] }, { "title": "C-X-C motif chemokine 12/C-X-C chemokine receptor type 7 signaling regulates breast cancer growth and metastasis by modulating the tumor microenvironment.", "journal": "Breast cancer research : BCR", "date": "2014", "authors": "Wani N, Nasser MW, Ahirwar DK, Zhao H, Miao Z, Shilo K, Ganju RK", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24886617", "url": "https://glygen.org/publication/PubMed/24886617" } ] }, { "title": "mTORC1 drives HIF-1alpha and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3.", "journal": "Oncogene", "date": "2015", "authors": "Dodd KM, Yang J, Shen MH, Sampson JR, Tee AR", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "24931163", "url": 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Gastrointestinal and liver physiology", "date": "2015", "authors": "Yu C, Huo X, Agoston AT, Zhang X, Theiss AL, Cheng E, Zhang Q, Zaika A, Pham TH, Wang DH, Lobie PE, Odze RD, Spechler SJ, Souza RF", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "26045618", "url": "https://glygen.org/publication/PubMed/26045618" } ] }, { "title": "Overexpression of microRNA-155 increases IL-21 mediated STAT3 signaling and IL-21 production in systemic lupus erythematosus.", "journal": "Arthritis research & therapy", "date": "2015", "authors": "Rasmussen TK, Andersen T, Bak RO, Yiu G, Sorensen CM, Stengaard-Pedersen K, Mikkelsen JG, Utz PJ, Holm CK, Deleuran B", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "26055806", "url": 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phytotherapy and phytopharmacology", "date": "2016", "authors": "Baek SH, Ko JH, Lee H, Jung J, Kong M, Lee JW, Lee J, Chinnathambi A, Zayed ME, Alharbi SA, Lee SG, Shim BS, Sethi G, Kim SH, Yang WM, Um JY, Ahn KS", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "27064016", "url": "https://glygen.org/publication/PubMed/27064016" } ] }, { "title": "Integrative Phosphoproteomics Links IL-23R Signaling with Metabolic Adaptation in Lymphocytes.", "journal": "Scientific reports", "date": "2016", "authors": "Lochmatter C, Fischer R, Charles PD, Yu Z, Powrie F, Kessler BM", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "27080861", "url": "https://glygen.org/publication/PubMed/27080861" } ] }, { "title": "Mitochondrial STAT3 and reactive oxygen 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"authors": "Lei CT, Su H, Ye C, Tang H, Gao P, Wan C, He FF, Wang YM, Zhang C", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "28881473", "url": "https://glygen.org/publication/PubMed/28881473" } ] }, { "title": "Physapubescin B inhibits tumorgenesis and circumvents taxol resistance of ovarian cancer cells through STAT3 signaling.", "journal": "Oncotarget", "date": "2017", "authors": "Zhao X, Huang L, Xu W, Chen X, Shen Y, Zeng W, Chen X", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29050266", "url": "https://glygen.org/publication/PubMed/29050266" } ] }, { "title": "High Content Imaging Assays for IL-6-Induced STAT3 Pathway Activation in Head and Neck Cancer Cell Lines.", "journal": "Methods in molecular biology (Clifton, N.J.)", "date": "2018", "authors": "Johnston Paul A, Sen Malabika, Hua Yun, Camarco Daniel P, Shun Tong Ying, Lazo John S, Grandis Jennifer R", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29082496", "url": "https://glygen.org/publication/PubMed/29082496" } ] }, { "title": "Radioresistance of mesenchymal glioblastoma initiating cells correlates with patient outcome and is associated with activation of inflammatory program.", "journal": "Oncotarget", "date": "2017", "authors": "Stanzani E, Martinez-Soler F, Mateos TM, Vidal N, Villanueva A, Pujana MA, Serra-Musach J, de la Iglesia N, Gimenez-Bonafe P, Tortosa A", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29088733", "url": "https://glygen.org/publication/PubMed/29088733" } ] }, { "title": "MMPP Attenuates Non-Small Cell Lung Cancer Growth by Inhibiting the STAT3 DNA-Binding Activity via Direct Binding to the STAT3 DNA-Binding Domain.", "journal": "Theranostics", "date": "2017", "authors": "Son DJ, Zheng J, Jung YY, Hwang CJ, Lee HP, Woo JR, Baek SY, Ham YW, Kang MW, Shong M, Kweon GR, Song MJ, Jung JK, Han SB, Kim BY, Yoon DY, Choi BY, Hong JT", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29158850", "url": "https://glygen.org/publication/PubMed/29158850" } ] }, { "title": "Interleukin-32alpha promotes the proliferation of multiple myeloma cells by inducing production of IL-6 in bone marrow stromal cells.", "journal": "Oncotarget", "date": "2017", "authors": "Lin X, Yang L, Wang G, Zi F, Yan H, Guo X, Chen J, Chen Q, Huang X, Li Y, Zhang E, Wu W, Yang Y, He D, He J, Cai Z", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29190960", "url": "https://glygen.org/publication/PubMed/29190960" } ] }, { "title": "C-C motif chemokine receptor 1 (CCR1) is a target of the EGF-AKT-mTOR-STAT3 signaling axis in breast cancer cells.", "journal": "Oncotarget", "date": "2017-11-07", "authors": "Shin Soon Young, Lee Da Hyun, Lee Jishin, Choi Chan, Kim Ji-Young, Nam Jeong-Seok, Lim Yoongho, Lee Young Han", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29212252", "url": "https://glygen.org/publication/PubMed/29212252" } ] }, { "title": "STAT3 mediates C6-ceramide-induced cell death in chronic lymphocytic leukemia.", "journal": "Signal transduction and targeted therapy", "date": "2017", "authors": "Doshi UA, Shaw J, Fox TE, Claxton DF, Loughran TP, Kester M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29263930", "url": "https://glygen.org/publication/PubMed/29263930" } ] }, { "title": "Inhibition of STAT3 Signaling Reduces IgA1 Autoantigen Production in IgA Nephropathy.", "journal": "Kidney international reports", "date": "2017", "authors": "Yamada K, Huang ZQ, Raska M, Reily C, Anderson JC, Suzuki H, Ueda H, Moldoveanu Z, Kiryluk K, Suzuki Y, Wyatt RJ, Tomino Y, Gharavi AG, Weinmann A, Julian BA, Willey CD, Novak J", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29270528", "url": "https://glygen.org/publication/PubMed/29270528" } ] }, { "title": "Reactive oxygen species released from astrocytes treated with amyloid beta oligomers elicit neuronal calcium signals that decrease phospho-Ser727-STAT3 nuclear content.", "journal": "Free radical biology & medicine", "date": "2018", "authors": "Munoz Y, Paula-Lima AC, Nunez MT", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29309895", "url": "https://glygen.org/publication/PubMed/29309895" } ] }, { "title": "Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability.", "journal": "Nature communications", "date": "2018", "authors": "Williams JJL, Alotaiq N, Mullen W, Burchmore R, Liu L, Baillie GS, Schaper F, Pilch PF, Palmer TM", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29330478", "url": "https://glygen.org/publication/PubMed/29330478" } ] }, { "title": "The CXCR4-STAT3-IL-10 Pathway Controls the Immunoregulatory Function of Chronic Lymphocytic Leukemia and Is Modulated by Lenalidomide.", "journal": "Frontiers in immunology", "date": "2017", "authors": "Shaim H, Estrov Z, Harris D, Hernandez Sanabria M, Liu Z, Ruvolo P, Thompson PA, Ferrajoli A, Daher M, Burger J, Muftuoglu M, Imahashi N, Li L, Liu E, Alsuliman AS, Basar R, Nassif Kerbauy L, Sobieski C, Gokdemir E, Kondo K, Wierda W, Keating M, Shpall EJ, Rezvani K", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29379494", "url": "https://glygen.org/publication/PubMed/29379494" } ] }, { "title": "Impact of STAT3 phosphorylation in glioblastoma stem cells radiosensitization and patient outcome.", "journal": "Oncotarget", "date": "2018", "authors": "Masliantsev K, Pinel B, Balbous A, Guichet PO, Tachon G, Milin S, Godet J, Duchesne M, Berger A, Petropoulos C, Wager M, Karayan-Tapon L", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29423098", "url": "https://glygen.org/publication/PubMed/29423098" } ] }, { "title": "Interaction between STAT3 and GLI1/tGLI1 oncogenic transcription factors promotes the aggressiveness of triple-negative breast cancers and HER2-enriched breast cancer.", "journal": "Oncogene", "date": "2018", "authors": "Sirkisoon SR, Carpenter RL, Rimkus T, Anderson A, Harrison A, Lange AM, Jin G, Watabe K, Lo HW", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29449694", "url": "https://glygen.org/publication/PubMed/29449694" } ] }, { "title": "Novel synthetic bisindolylmaleimide alkaloids inhibit STAT3 activation by binding to the SH2 domain and suppress breast xenograft tumor growth.", "journal": "Oncogene", "date": "2018-05", "authors": "Li Xia, Ma Hongguang, Li Lin, Chen Yifan, Sun Xiao, Dong Zizheng, Liu Jing-Yuan, Zhu Weiming, Zhang Jian-Ting", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29456240", "url": "https://glygen.org/publication/PubMed/29456240" } ] }, { "title": "Under-expression of CK2beta subunit in ccRCC represents a complementary biomarker of p-STAT3 Ser727 that correlates with patient survival.", "journal": "Oncotarget", "date": "2018", "authors": "Vilardell J, Alcaraz E, Sarro E, Trilla E, Cuadros T, de Torres I, Plana M, Ramon Y Cajal S, Pinna LA, Ruzzene M, Morote J, Meseguer A, Itarte E", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29464030", "url": "https://glygen.org/publication/PubMed/29464030" } ] }, { "title": "Bilateral activation of STAT3 by phosphorylation at the tyrosine-705 (Y705) and serine-727 (S727) positions and its nuclear translocation in primary sensory neurons following unilateral sciatic nerve injury.", "journal": "Histochemistry and cell biology", "date": "2018", "authors": "Dubovy P, Hradilova-Svizenska I, Klusakova I, Kokosova V, Brazda V, Joukal M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29488000", "url": "https://glygen.org/publication/PubMed/29488000" } ] }, { "title": "STAT3 precedes HIF1alpha transcriptional responses to oxygen and oxygen and glucose deprivation in human brain pericytes.", "journal": "PloS one", "date": "2018", "authors": "Carlsson R, Ozen I, Barbariga M, Gaceb A, Roth M, Paul G", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29518129", "url": "https://glygen.org/publication/PubMed/29518129" } ] }, { "title": "YM155 decreases radiation-induced invasion and reverses epithelial-mesenchymal transition by targeting STAT3 in glioblastoma.", "journal": "Journal of translational medicine", "date": "2018-03-23", "authors": "Zhang Xin, Wang Xuehai, Xu Ran, Ji Jianxiong, Xu Yangyang, Han Mingzhi, Wei Yuzhen, Huang Bin, Chen Anjing, Zhang Qing, Li Wenjie, Wang Jian, Li Xingang, Qiu Chen", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29571296", "url": "https://glygen.org/publication/PubMed/29571296" } ] }, { "title": "Bt354 as a new STAT3 signaling pathway inhibitor against triple negative breast cancer.", "journal": "Journal of drug targeting", "date": "2018", "authors": "Chen Y, Ji M, Zhang S, Xue N, Xu H, Lin S, Chen X", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29595328", "url": "https://glygen.org/publication/PubMed/29595328" } ] }, { "title": "Aberrant cell signalling in PBMCs upon IFN-alpha stimulation in primary Sjogren's syndrome patients associates with type I interferon signature.", "journal": "European journal of immunology", "date": "2018", "authors": "Davies R, Hammenfors D, Bergum B, Vogelsang P, Gavasso S, Brun JG, Jonsson R, Appel S", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29604049", "url": "https://glygen.org/publication/PubMed/29604049" } ] }, { "title": "STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle.", "journal": "PLoS pathogens", "date": "2018-04", "authors": "Morgan Ethan L, Wasson Christopher W, Hanson Lucy, Kealy David, Pentland Ieisha, McGuire Victoria, Scarpini Cinzia, Coleman Nicholas, Arthur J Simon C, Parish Joanna L, Roberts Sally, Macdonald Andrew", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29630659", "url": "https://glygen.org/publication/PubMed/29630659" } ] }, { "title": "GADD45A and CDKN1A are involved in apoptosis and cell cycle modulatory effects of viscumTT with further inactivation of the STAT3 pathway.", "journal": "Scientific reports", "date": "2018", "authors": "Kleinsimon S, Longmuss E, Rolff J, Jager S, Eggert A, Delebinski C, Seifert G", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29636527", "url": "https://glygen.org/publication/PubMed/29636527" } ] }, { "title": "Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes.", "journal": "PloS one", "date": "2018", "authors": "Baker J, Falconer AMD, Wilkinson DJ, Europe-Finner GN, Litherland GJ, Rowan AD", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29652915", "url": "https://glygen.org/publication/PubMed/29652915" } ] }, { "title": "Cooperative STAT/NF-kappaB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression.", "journal": "Nature communications", "date": "2018", "authors": "Feist M, Schwarzfischer P, Heinrich P, Sun X, Kemper J, von Bonin F, Perez-Rubio P, Taruttis F, Rehberg T, Dettmer K, Gronwald W, Reinders J, Engelmann JC, Dudek J, Klapper W, Trumper L, Spang R, Oefner PJ, Kube D", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29666362", "url": "https://glygen.org/publication/PubMed/29666362" } ] }, { "title": "A novel tricarbonylmethane agent (CMC2.24) reduces human pancreatic tumor growth in mice by targeting Ras.", "journal": "Molecular carcinogenesis", "date": "2018", "authors": "Mallangada NA, Vargas JM, Thomas S, DiGiovanni MG, Vaeth BM, Nemesure MD, Wang R, LaComb JF, Williams JL, Golub LM, Johnson F, Mackenzie GG", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29683208", "url": "https://glygen.org/publication/PubMed/29683208" } ] }, { "title": "Curcumin interacts directly with the Cysteine 259 residue of STAT3 and induces apoptosis in H-Ras transformed human mammary epithelial cells.", "journal": "Scientific reports", "date": "2018", "authors": "Hahn YI, Kim SJ, Choi BY, Cho KC, Bandu R, Kim KP, Kim DH, Kim W, Park JS, Han BW, Lee J, Na HK, Cha YN, Surh YJ", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29686295", "url": "https://glygen.org/publication/PubMed/29686295" } ] }, { "title": "The critical role that STAT3 plays in glioma-initiating cells: STAT3 addiction in glioma.", "journal": "Oncotarget", "date": "2018", "authors": "Ganguly D, Fan M, Yang CH, Zbytek B, Finkelstein D, Roussel MF, Pfeffer LM", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29774125", "url": "https://glygen.org/publication/PubMed/29774125" } ] }, { "title": "Chemical and genetic inhibition of STAT3 sensitizes hepatocellular carcinoma cells to sorafenib induced cell death.", "journal": "International journal of biological sciences", "date": "2018", "authors": "Xie L, Zeng Y, Dai Z, He W, Ke H, Lin Q, Chen Y, Bu J, Lin D, Zheng M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29805309", "url": "https://glygen.org/publication/PubMed/29805309" } ] }, { "title": "C1q/TNF-related peptide 8 (CTRP8) promotes temozolomide resistance in human glioblastoma.", "journal": "Molecular oncology", "date": "2018", "authors": "Thanasupawat T, Glogowska A, Burg M, Krcek J, Beiko J, Pitz M, Zhang GJ, Hombach-Klonisch S, Klonisch T", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29949238", "url": "https://glygen.org/publication/PubMed/29949238" } ] }, { "title": "Interstitial flow promotes macrophage polarization toward an M2 phenotype.", "journal": "Molecular biology of the cell", "date": "2018", "authors": "Li R, Serrano JC, Xing H, Lee TA, Azizgolshani H, Zaman M, Kamm RD", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "29995595", "url": "https://glygen.org/publication/PubMed/29995595" } ] }, { "title": "STAT3, a Hub Protein of Cellular Signaling Pathways, Is Triggered by beta-Hexaclorocyclohexane.", "journal": "International journal of molecular sciences", "date": "2018", "authors": "Rubini E, Altieri F, Chichiarelli S, Giamogante F, Carissimi S, Paglia G, Macone A, Eufemi M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30036966", "url": "https://glygen.org/publication/PubMed/30036966" } ] }, { "title": "STAT3 is constitutively activated in chronic active Epstein-Barr virus infection and can be a therapeutic target.", "journal": "Oncotarget", "date": "2018", "authors": "Onozawa E, Shibayama H, Takada H, Imadome KI, Aoki S, Yoshimori M, Shimizu N, Fujiwara S, Koyama T, Miura O, Arai A", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30123428", "url": "https://glygen.org/publication/PubMed/30123428" } ] }, { "title": "STAT3 associates with vacuolar H(+)-ATPase and regulates cytosolic and lysosomal pH.", "journal": "Cell research", "date": "2018", "authors": "Liu B, Palmfeldt J, Lin L, Colaco A, Clemmensen KKB, Huang J, Xu F, Liu X, Maeda K, Luo Y, Jaattela M", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30127373", "url": "https://glygen.org/publication/PubMed/30127373" } ] }, { "title": "STAT3 Knockdown Induces Tumor Formation by MDA-MB-231 Cells.", "journal": "Clinical oncology and research", "date": "2018", "authors": "Banerjee K, Pru C, Pru JK, Resat H", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30234199", "url": "https://glygen.org/publication/PubMed/30234199" } ] }, { "title": "STAT3 is constitutively acetylated on lysine 685 residues in chronic lymphocytic leukemia cells.", "journal": "Oncotarget", "date": "2018", "authors": "Rozovski U, Harris DM, Li P, Liu Z, Jain P, Ferrajoli A, Burger J, Thompson P, Jain N, Wierda W, Keating MJ, Estrov Z", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30263097", "url": "https://glygen.org/publication/PubMed/30263097" } ] }, { "title": "Inhibition of STAT3 blocks protein synthesis and tumor metastasis in osteosarcoma cells.", "journal": "Journal of experimental & clinical cancer research : CR", "date": "2018-10-04", "authors": "Zuo Dongqing, Shogren Kristen L, Zang Jie, Jewison Donna E, Waletzki Brian E, Miller Alan L, Okuno Scott H, Cai Zhengdong, Yaszemski Michael J, Maran Avudaiappan", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30286779", "url": "https://glygen.org/publication/PubMed/30286779" } ] }, { "title": "YL064 directly inhibits STAT3 activity to induce apoptosis of multiple myeloma cells.", "journal": "Cell death discovery", "date": "2018", "authors": "Wang Y, Wu L, Cai H, Lei H, Ma CM, Yang L, Xu H, Zhu Q, Yao Z, Wu Y", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30302278", "url": "https://glygen.org/publication/PubMed/30302278" } ] }, { "title": "Downregulation of signal transduction and STAT3 expression exacerbates oxidative stress mediated by NLRP3 inflammasome.", "journal": "Neural regeneration research", "date": "2018", "authors": "Bai H, Zhang QF, Duan JJ, Yu DJ, Liu LJ", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30323145", "url": "https://glygen.org/publication/PubMed/30323145" } ] }, { "title": "2'-Hydroxycinnamaldehyde inhibits proliferation and induces apoptosis via signal transducer and activator of transcription 3 inactivation and reactive oxygen species generation.", "journal": "Cancer science", "date": "2019", "authors": "Yoon YJ, Kim YH, Lee YJ, Choi J, Kim CH, Han DC, Kwon BM", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30375708", "url": "https://glygen.org/publication/PubMed/30375708" } ] }, { "title": "Dual androgen receptor (AR) and STAT3 inhibition by a compound targeting the AR amino-terminal domain.", "journal": "Pharmacology research & perspectives", "date": "2018-12", "authors": "Hua Yaping, Azeem Waqas, Shen Yunheng, Zhang Shoude, Olsen Jan R, \u00d8yan Anne M, Ke Xisong, Zhang Weidong, Kalland Karl-Henning", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30410767", "url": "https://glygen.org/publication/PubMed/30410767" } ] }, { "title": "PLOD3 promotes lung metastasis via regulation of STAT3.", "journal": "Cell death & disease", "date": "2018", "authors": "Baek JH, Yun HS, Kwon GT, Kim JY, Lee CW, Song JY, Um HD, Kang CM, Park JK, Kim JS, Kim EH, Hwang SG", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "30442941", "url": "https://glygen.org/publication/PubMed/30442941" } ] }, { 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Chen H, Kang Y, Wang J, Zhou X, Feng Y, Zhang P", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "32319563", "url": "https://glygen.org/publication/PubMed/32319563" } ] }, { "title": "HSulf1 and palbociclib exert synergistic antitumor effects on RBpositive triplenegative breast cancer.", "journal": "International journal of oncology", "date": "2020", "authors": "Chen F, Zhang Z, Yu Y, Liu Q, Pu F", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "32377705", "url": "https://glygen.org/publication/PubMed/32377705" } ] }, { "title": "Ascites-derived ALDH+CD44+ tumour cell subsets endow stemness, metastasis and metabolic switch via PDK4-mediated STAT3/AKT/NF-\u03baB/IL-8 signalling in ovarian cancer.", "journal": "British journal of cancer", "date": "2020-07", "authors": "Jiang Yu-Xin, Siu Michelle Kwan-Yee, Wang Jing-Jing, Mo Xue-Tang, Leung Thomas Ho-Yin, Chan David Wai, Cheung Annie Nga-Yin, Ngan Hextan Yuen-Sheung, Chan Karen Kar-Loen", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "32390009", "url": "https://glygen.org/publication/PubMed/32390009" } ] }, { "title": "The STAT3-miR-223-TGFBR3/HMGCS1 axis modulates the progression of cervical carcinoma.", "journal": "Molecular oncology", "date": "2020-09", "authors": "Zhang Ju, Jiang Ming, Qian Lili, Lin Xiao, Song Weiguo, Gao Yunfeng, Zhou Ying", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "32491253", "url": "https://glygen.org/publication/PubMed/32491253" } ] }, { "title": "Plasticity of High-Density Neutrophils in Multiple Myeloma is Associated with Increased Autophagy Via STAT3.", "journal": "International journal of molecular sciences", "date": "2019", "authors": "Puglisi F, Parrinello NL, Giallongo C, Cambria D, Camiolo G, Bellofiore C, Conticello C, Del Fabro V, Leotta V, Markovic U, Sapienza G, Barbato A, Scalese S, Tibullo D, Brundo MV, Palumbo GA, Di Raimondo F, Romano A", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40763" } ], "reference": [ { "type": "PubMed", "id": "32565533", "url": "https://glygen.org/publication/PubMed/32565533" } ] }, { "title": "CagA orchestrates eEF1A1 and PKC\u03b4 to induce interleukin-6 expression in Helicobacter pylori-infected gastric epithelial cells.", "journal": "Gut pathogens", "date": "2020", "authors": "Xu Shaohan, Wu Xiaoqian, Zhang Xiaoyan, Chen Chu, Chen Hao, She Feifei", "evidence": [ { "database": "iPTMnet", "id": "P40763", "url": 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"https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification 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"https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] }, { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1324", "name": "lung cancer", 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"description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", 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"description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). 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"https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] }, { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary 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"https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": 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Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": 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"https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). 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"" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). 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Endocrinology and metabolism", "date": "2010", "authors": "Uebi T, Tamura M, Horike N, Hashimoto YK, Takemori H", "evidence": [ { "database": "iPTMnet", "id": "Q53ET0", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q53ET0" } ], "reference": [ { "type": "PubMed", "id": "20551288", "url": "https://glygen.org/publication/PubMed/20551288" } ] }, { "title": "14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.", "journal": "Journal of cell science", "date": "2005", "authors": "Al-Hakim AK, Goransson O, Deak M, Toth R, Campbell DG, Morrice NA, Prescott AR, Alessi DR", "evidence": [ { "database": "iPTMnet", "id": "Q53ET0", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q53ET0" } ], "reference": [ { "type": "PubMed", "id": "16306228", "url": "https://glygen.org/publication/PubMed/16306228" } ] }, { "title": "Molecular identification and characterization of a family of kinases with homology to Ca2+/calmodulin-dependent protein kinases I/IV.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Ohmae S, Takemoto-Kimura S, Okamura M, Adachi-Morishima A, Nonaka M, Fuse T, Kida S, Tanji M, Furuyashiki T, Arakawa Y, Narumiya S, Okuno H, Bito H", "evidence": [ { "database": "iPTMnet", "id": "Q53ET0", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q53ET0" } ], "reference": [ { "type": "PubMed", "id": "16684769", "url": "https://glygen.org/publication/PubMed/16684769" } ] }, { "title": "TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1.", "journal": "Cell metabolism", "date": "2009", "authors": "Ryu D, Oh KJ, Jo HY, Hedrick S, Kim YN, Hwang YJ, Park TS, Han JS, Choi CS, Montminy M, Koo SH", "evidence": [ { "database": "iPTMnet", "id": "Q53ET0", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q53ET0" } ], "reference": [ { "type": "PubMed", "id": "19254569", "url": "https://glygen.org/publication/PubMed/19254569" } ] }, { "title": "CREB-regulated transcription co-activator family stimulates promoter II-driven aromatase expression in preadipocytes.", "journal": "Hormones & cancer", "date": "2013", "authors": "Samarajeewa NU, Docanto MM, Simpson ER, Brown KA", "evidence": [ { "database": "iPTMnet", "id": "Q53ET0", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q53ET0" } ], "reference": [ { "type": "PubMed", "id": "23584792", "url": "https://glygen.org/publication/PubMed/23584792" } ] }, { "title": "Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation: evolutionary implications of the uricase loss in hominids.", "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology", "date": "2014", "authors": "Cicerchi C, Li N, Kratzer J, Garcia G, Roncal-Jimenez CA, Tanabe K, Hunter B, Rivard CJ, Sautin YY, Gaucher EA, Johnson RJ, Lanaspa MA", "evidence": [ { "database": "iPTMnet", "id": 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"https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] }, { "evidence": [ { "id": "rs145629242", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs145629242" }, { "id": "rs145629242", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs145629242" }, { "id": "rs145629242", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs145629242" }, { "id": "rs145629242", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs145629242#frequency_tab" }, { "id": "rs145629242", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs145629242" } ], "glycoeffect": [ "o-glyco-site-loss" ], 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"MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 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}, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" 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"url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "all_sites": [ { "type": "glycosylation", "site_list": [ { "start_pos": "123", "end_pos": "123" }, { "start_pos": "669", 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"familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": 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Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": 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[], "subjects_tested": "720", "subjects_positive": "1", "frequency": "0.1", "sequence_org": "K", "sequence_mut": "R", "comment": "Somatic mutation passed 1 filters: num. of cancers (3).", "chr_id": "2", "chr_pos": "47819071", "ref_nt": "T", "alt_nt": "C", "minor_allelic_frequency": "", "site_lbl": "K602", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": 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"MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). 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tumorigenesis.", "journal": "Cancer research", "date": "2013", "authors": "Martini M, Russo M, Lamba S, Vitiello E, Crowley EH, Sassi F, Romanelli D, Frattini M, Marchetti A, Bardelli A", "evidence": [ { "database": "iPTMnet", "id": "Q02750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q02750" } ], "reference": [ { "type": "PubMed", "id": "23319808", "url": "https://glygen.org/publication/PubMed/23319808" } ] }, { "title": "Changes in androgen receptor nongenotropic signaling correlate with transition of LNCaP cells to androgen independence.", "journal": "Cancer research", "date": "2004", "authors": "Unni E, Sun S, Nan B, McPhaul MJ, Cheskis B, Mancini MA, Marcelli M", "evidence": [ { "database": "iPTMnet", "id": "Q02750-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q02750-1" } ], "reference": [ { "type": "PubMed", "id": "15466214", "url": "https://glygen.org/publication/PubMed/15466214" } ] }, { "title": "Nuclear localization of mitogen-activated 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"url": "https://glygen.org/publication/PubMed/8157000" } ] }, { "title": "Activation of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase by G protein and tyrosine kinase oncoproteins.", "journal": "The Journal of biological chemistry", "date": "1993", "authors": "Gardner AM, Vaillancourt RR, Johnson GL", "evidence": [ { "database": "iPTMnet", "id": "Q02750-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q02750-1" } ], "reference": [ { "type": "PubMed", "id": "8394352", "url": "https://glygen.org/publication/PubMed/8394352" } ] }, { "title": "Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells.", "journal": "The Journal of biological chemistry", "date": "1996", "authors": "Wu X, Noh SJ, Zhou G, Dixon JE, Guan KL", "evidence": [ { "database": "iPTMnet", "id": "Q02750-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q02750-1" } ], "reference": [ { "type": "PubMed", "id": "8621729", "url": "https://glygen.org/publication/PubMed/8621729" } ] }, { "title": "The small GTP-binding protein R-Ras can influence integrin activation by antagonizing a Ras/Raf-initiated integrin suppression pathway.", "journal": "Molecular biology of the cell", "date": "1999", "authors": "Sethi T, Ginsberg MH, Downward J, Hughes PE", "evidence": [ { "database": "iPTMnet", "id": "Q02750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q02750" } ], "reference": [ { "type": "PubMed", "id": "10359597", "url": "https://glygen.org/publication/PubMed/10359597" } ] }, { "title": "Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2.", "journal": "Oncogene", "date": "2007", "authors": "Moniz S, Verissimo F, Matos P, Brazao R, Silva E, Kotelevets L, Chastre E, Gespach C, Jordan P", "evidence": [ { "database": "iPTMnet", "id": "Q02750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q02750" } ], "reference": [ { "type": "PubMed", "id": "17667937", "url": "https://glygen.org/publication/PubMed/17667937" } ] }, { "title": "Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase.", "journal": "The EMBO journal", "date": "1996", "authors": "Salmeron A, Ahmad TB, Carlile GW, Pappin D, Narsimhan RP, Ley SC", "evidence": [ { "database": "iPTMnet", "id": "Q02750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q02750" } ], "reference": [ { "type": "PubMed", "id": "8631303", "url": "https://glygen.org/publication/PubMed/8631303" } ] }, { "title": "Identification of 2 serine residues of MEK-1 that are differentially phosphorylated during activation by raf and MEK kinase.", "journal": "The Journal of biological chemistry", "date": "1994", "authors": "Yan M, Templeton DJ", "evidence": [ { "database": "iPTMnet", "id": "Q02750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q02750" } ], "reference": [ { "type": "PubMed", "id": "8034665", "url": "https://glygen.org/publication/PubMed/8034665" } ] }, { "title": "Mixed lineage kinase MLK4 is activated in colorectal cancers where it synergistically cooperates with activated RAS signaling in driving tumorigenesis.", "journal": "Cancer research", "date": "2013", "authors": "Martini M, Russo M, Lamba S, Vitiello E, Crowley EH, Sassi F, Romanelli D, Frattini M, Marchetti A, Bardelli A", "evidence": [ { "database": "iPTMnet", "id": "Q02750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q02750" } ], "reference": [ { "type": "PubMed", "id": "23319808", "url": "https://glygen.org/publication/PubMed/23319808" } ] }, { "title": "Changes in androgen receptor nongenotropic signaling correlate with transition of LNCaP cells to androgen independence.", "journal": "Cancer research", "date": "2004", "authors": "Unni E, Sun S, Nan B, McPhaul MJ, Cheskis B, Mancini MA, Marcelli M", "evidence": [ { "database": "iPTMnet", "id": "Q02750-1", "url": 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Requirement for phosphorylation at the activation lip and signaling downstream of MKK.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Tolwinski NS, Shapiro PS, Goueli S, Ahn NG", "evidence": [ { "database": "iPTMnet", "id": "Q02750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q02750" } ], "reference": [ { "type": "PubMed", "id": "10037701", "url": "https://glygen.org/publication/PubMed/10037701" } ] }, { "title": "Mitogen-activated protein kinase feedback phosphorylation regulates MEK1 complex formation and activation during cellular adhesion.", "journal": "Molecular and cellular biology", "date": "2004", "authors": "Eblen ST, Slack-Davis JK, Tarcsafalvi A, Parsons JT, Weber MJ, Catling AD", "evidence": [ { "database": "iPTMnet", "id": "Q02750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q02750" } ], "reference": [ { "type": "PubMed", "id": "14993270", "url": "https://glygen.org/publication/PubMed/14993270" } ] }, { "title": "Fully activated MEK1 exhibits compromised affinity for binding of allosteric inhibitors U0126 and PD0325901.", "journal": "Biochemistry", "date": "2011", "authors": "Sheth PR, Liu Y, Hesson T, Zhao J, Vilenchik L, Liu YH, Mayhood TW, Le HV", "evidence": [ { "database": "iPTMnet", "id": "Q02750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q02750" } ], "reference": [ { "type": "PubMed", "id": "21793567", "url": "https://glygen.org/publication/PubMed/21793567" } ] }, { "title": "MEK1/2 dual-specificity protein kinases: structure and regulation.", "journal": "Biochemical and biophysical research communications", "date": "2012", "authors": "Roskoski R Jr", "evidence": [ { "database": "Reactome", "id": "R-HSA-445144", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-445144" }, { "database": "iPTMnet", "id": "Q02750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q02750" } ], "reference": [ { "type": "PubMed", "id": "22177953", "url": "https://glygen.org/publication/PubMed/22177953" } ] }, { "title": "A Phos-tag SDS-PAGE method that effectively uses phosphoproteomic data for profiling the phosphorylation dynamics of MEK1.", "journal": "Proteomics", "date": "2016", "authors": "Kinoshita E, Kinoshita-Kikuta E, Kubota Y, Takekawa M, Koike T", "evidence": [ { "database": "iPTMnet", "id": "Q02750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q02750" } ], "reference": [ { "type": "PubMed", "id": "27169363", "url": "https://glygen.org/publication/PubMed/27169363" } ] }, { "title": "Increase in constitutively active MEK1 species by introduction of MEK1 mutations identified in cancers.", "journal": "Biochimica et biophysica acta. Proteins and proteomics", "date": "2019", "authors": "Kinoshita-Kikuta E, Kinoshita E, Ueda S, Ino Y, Kimura Y, Hirano H, Koike T", "evidence": [ { "database": "iPTMnet", "id": "Q02750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q02750" } ], "reference": [ { "type": "PubMed", "id": "29753091", "url": "https://glygen.org/publication/PubMed/29753091" } ] }, { "title": "Allosteric Kinase Inhibitors Reshape MEK1 Kinase Activity Conformations in Cells and In Silico.", "journal": "Biomolecules", "date": "2021-03-30", "authors": "Fleischmann Jakob, Feichtner Andreas, DeFalco Louis, Kugler Valentina, Schwaighofer Selina, Huber Roland G, Stefan Eduard", "evidence": [ { "database": "iPTMnet", "id": "Q02750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q02750" } ], "reference": [ { "type": "PubMed", "id": "33808483", "url": "https://glygen.org/publication/PubMed/33808483" } ] }, { "title": "MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1995", "authors": "Xu S, Robbins D, Frost J, Dang A, Lange-Carter C, Cobb MH", "evidence": [ { "database": "iPTMnet", "id": "Q02750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q02750" } ], "reference": [ { "type": "PubMed", "id": "7624324", "url": "https://glygen.org/publication/PubMed/7624324" } ] }, { "title": "Interdependent domains controlling the enzymatic activity of mitogen-activated protein kinase kinase 1.", "journal": "Biochemistry", "date": "1996-12-03", "authors": "Mansour S J, Candia J M, Matsuura J E, Manning M C, Ahn N G", "evidence": [ { "database": "iPTMnet", "id": "Q02750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q02750" } ], "reference": [ { "type": "PubMed", "id": "8952507", "url": "https://glygen.org/publication/PubMed/8952507" } ] }, { "title": "Nek10 mediates G2/M cell cycle arrest and 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"MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ], "unlinked_id_list": [ "DOID:4765" ], "evidence": [ { "id": "1324", 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"description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", 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"MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the 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"DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ], "unlinked_id_list": [ "DOID:4765" ], "evidence": [ { "id": "1324", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1324" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] }, { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "unlinked_id_list": [ "DOID:3017", "DOID:0050938" ], "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" 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"" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] }, { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "3571", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3571" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "5041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5041" } ] }, { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric 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"resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] }, { "disease_id": "DOID:2531", "recommended_name": { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "hematologic cancer", "description": "An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes." }, "synonyms": [ { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematologic malignancy", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2531", "name": "Hematologic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", 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"https://disease-ontology.org/term/DOID:2531", "name": "malignant hematopoietic neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:0081452", "DOID:706", "DOID:1039", "DOID:5604", "DOID:6536", "DOID:0080638", "DOID:7757", "DOID:0050743", "DOID:4960", "DOID:8527", "DOID:1036", "DOID:5772" ], "evidence": [ { "id": "2531", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2531" } ] }, { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": 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