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Healy DG, Nishio K, Staddon J, Duchen MR, Hardy J, Schapira AH, Cooper JM", "evidence": [ { "database": "iPTMnet", "id": "Q5S006", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5S006" } ], "reference": [ { "type": "PubMed", "id": "22736029", "url": "https://glygen.org/publication/PubMed/22736029" } ] }, { "title": "GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor.", "journal": "Bioorganic & medicinal chemistry letters", "date": "2012", "authors": "Reith AD, Bamborough P, Jandu K, Andreotti D, Mensah L, Dossang P, Choi HG, Deng X, Zhang J, Alessi DR, Gray NS", "evidence": [ { "database": "iPTMnet", "id": "Q5S006", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5S006" } ], "reference": [ { "type": "PubMed", "id": "22863203", "url": "https://glygen.org/publication/PubMed/22863203" } ] }, { "title": "Brain Penetrant LRRK2 Inhibitor.", "journal": "ACS medicinal chemistry letters", "date": "2012", "authors": "Choi HG, Zhang J, Deng X, Hatcher JM, Patricelli MP, Zhao Z, Alessi DR, Gray NS", "evidence": [ { "database": "iPTMnet", "id": "Q5S006", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5S006" } ], "reference": [ { "type": "PubMed", "id": "23066449", "url": "https://glygen.org/publication/PubMed/23066449" } ] }, { "title": "LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein.", "journal": "Journal of neuroinflammation", "date": "2012", "authors": "Marker DF, Puccini JM, Mockus TE, Barbieri J, Lu SM, Gelbard HA", "evidence": [ { "database": "iPTMnet", "id": "Q5S006", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5S006" } ], "reference": [ { "type": "PubMed", "id": "23190742", "url": "https://glygen.org/publication/PubMed/23190742" } ] }, { "title": "Leucine-rich repeat kinase 2 functionally interacts with microtubules and kinase-dependently modulates cell migration.", "journal": 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"2015", "authors": "Zhao J, Molitor TP, Langston JW, Nichols RJ", "evidence": [ { "database": "iPTMnet", "id": "Q5S006", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5S006" } ], "reference": [ { "type": "PubMed", "id": "25939886", "url": "https://glygen.org/publication/PubMed/25939886" } ] }, { "title": "Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor.", "journal": "ACS medicinal chemistry letters", "date": "2015", "authors": "Hatcher JM, Zhang J, Choi HG, Ito G, Alessi DR, Gray NS", "evidence": [ { "database": "iPTMnet", "id": "Q5S006", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5S006" } ], "reference": [ { "type": "PubMed", "id": "26005538", "url": "https://glygen.org/publication/PubMed/26005538" } ] }, { "title": "Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors.", "journal": "The Biochemical journal", "date": "2016", "authors": "Ito G, Katsemonova K, Tonelli F, Lis P, Baptista MA, Shpiro N, Duddy G, Wilson S, Ho PW, Ho SL, Reith AD, Alessi DR", "evidence": [ { "database": "iPTMnet", "id": "Q5S006", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5S006" } ], "reference": [ { "type": "PubMed", "id": "27474410", "url": "https://glygen.org/publication/PubMed/27474410" } ] }, { "title": "Pharmacological LRRK2 kinase inhibition induces LRRK2 protein destabilization and proteasomal degradation.", "journal": "Scientific reports", "date": "2016", "authors": "Lobbestael E, Civiero L, De Wit T, Taymans JM, Greggio E, Baekelandt V", "evidence": [ { "database": "iPTMnet", "id": "Q5S006", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5S006" } ], "reference": [ { "type": "PubMed", "id": "27658356", "url": "https://glygen.org/publication/PubMed/27658356" } ] }, { "title": "Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of beta-catenin signaling.", "journal": "Molecular neurodegeneration", "date": "2017", "authors": "Berwick DC, Javaheri B, Wetzel A, Hopkinson M, Nixon-Abell J, Granno S, Pitsillides AA, Harvey K", "evidence": [ { "database": "iPTMnet", "id": "Q5S006", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5S006" } ], "reference": [ { "type": "PubMed", "id": "28103901", "url": "https://glygen.org/publication/PubMed/28103901" } ] }, { "title": "LRRK2 promotes the activation of NLRC4 inflammasome during Salmonella Typhimurium infection.", "journal": "The Journal of experimental medicine", "date": "2017", "authors": "Liu W, Liu X, Li Y, Zhao J, Liu Z, Hu Z, Wang Y, Yao Y, Miller AW, Su B, Cookson MR, Li X, Kang Z", "evidence": [ { "database": "iPTMnet", "id": "Q5S006", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5S006" } ], "reference": [ { "type": "PubMed", "id": "28821568", "url": "https://glygen.org/publication/PubMed/28821568" } ] }, { "title": "Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity.", "journal": "NPJ Parkinson's disease", "date": "2018", "authors": "Kluss JH, Conti MM, Kaganovich A, Beilina A, Melrose HL, Cookson MR, Mamais A", "evidence": [ { "database": "iPTMnet", "id": "Q5S006", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5S006" } ], "reference": [ { "type": "PubMed", "id": "29707617", "url": "https://glygen.org/publication/PubMed/29707617" } ] }, { "title": "LRRK2 activity does not dramatically alter alpha-synuclein pathology in primary neurons.", "journal": "Acta neuropathologica communications", "date": "2018", "authors": "Henderson MX, Peng C, Trojanowski JQ, Lee VMY", "evidence": [ { "database": "iPTMnet", "id": "Q5S006", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5S006" } ], "reference": [ { "type": "PubMed", "id": "29855356", "url": "https://glygen.org/publication/PubMed/29855356" } ] }, { "title": "Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin mice.", "journal": "Neurobiology of disease", "date": "2018", "authors": "Zhao Y, Keshiya S, Atashrazm F, Gao J, Ittner LM, Alessi DR, Halliday GM, Fu Y, Dzamko N", "evidence": [ { "database": "iPTMnet", "id": "Q5S006", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5S006" } ], "reference": [ { "type": "PubMed", "id": "30194047", "url": "https://glygen.org/publication/PubMed/30194047" } ] }, { "title": "Leucine-rich repeat kinase 2 (LRRK2) inhibitors differentially modulate glutamate release and Serine935 LRRK2 phosphorylation in striatal and cerebrocortical synaptosomes.", "journal": "Pharmacology research & perspectives", "date": "2019", "authors": "Mercatelli D, Bolognesi P, Frassineti M, Pisano CA, Longo F, Shimshek DR, Morari M", "evidence": [ { "database": "iPTMnet", "id": "Q5S006", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5S006" } ], "reference": [ { "type": "PubMed", "id": "31149340", "url": "https://glygen.org/publication/PubMed/31149340" } ] }, { "title": "LRRK2 activation controls the repair of damaged endomembranes in macrophages.", "journal": "The EMBO journal", "date": "2020-09-15", "authors": "Herbst Susanne, Campbell Philip, Harvey John, Bernard Elliott M, Papayannopoulos Venizelos, Wood Nicholas W, Morris Huw R, Gutierrez Maximiliano G", "evidence": [ { "database": "iPTMnet", "id": "Q5S006", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5S006" } ], "reference": [ { "type": "PubMed", "id": "32643832", "url": "https://glygen.org/publication/PubMed/32643832" } ] }, { "title": "Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues.", "journal": "Cells", "date": "2020", "authors": "Iannotta L, Biosa A, Kluss JH, Tombesi G, Kaganovich A, Cogo S, Plotegher N, Civiero L, Lobbestael E, Baekelandt V, Cookson MR, Greggio E", "evidence": [ { "database": "iPTMnet", "id": "Q5S006", "url": 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