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Increased insulin-induced phosphorylation at Ser-253 and binding of 14-3-3 proteins; when associated with A-24; Q-219; Q-242; Q-259; Q-262; Q-271 and Q-291.", "evidence": [ { "database": "UniProtKB", "id": "Q9R1E0", "url": "https://www.uniprot.org/uniprotkb/Q9R1E0" }, { "database": "PubMed", "id": "22510882", "url": "https://glygen.org/publication/PubMed/22510882" }, { "database": "PubMed", "id": "15220471", "url": "https://glygen.org/publication/PubMed/15220471" }, { "database": "PubMed", "id": "16076959", "url": "https://glygen.org/publication/PubMed/16076959" }, { "database": "PubMed", "id": "17090532", "url": "https://glygen.org/publication/PubMed/17090532" }, { "database": "PubMed", "id": "20519497", "url": "https://glygen.org/publication/PubMed/20519497" } ] }, { "sequence_org": "K", "sequence_mut": "Q", "comment": "Mimics acetylation. Decreased DNA-binding by about half. Enhanced phosphorylation by PKB/AKT1, no effect on interaction with CEBPA; when associated with either A-242 or Q-242 and either A-262 or Q-262. Cytoplasmic location in absence or presence of insulin, no change on the inhibitory effect of oxidative stress on insulin-induced phosphorylations, but no inhibition of these phosphorylations by resveratrol; when associated with Q-219; Q-242; Q-259; Q-262; Q-271 and Q-291. Increased insulin-induced phosphorylation at Ser-253 and binding of 14-3-3 proteins; when associated with A-24; Q-219; Q-242; Q-259; Q-262; Q-271 and Q-291.", "evidence": [ { "database": "UniProtKB", "id": "Q9R1E0", "url": "https://www.uniprot.org/uniprotkb/Q9R1E0" }, { "database": "PubMed", "id": "22510882", "url": "https://glygen.org/publication/PubMed/22510882" }, { "database": "PubMed", "id": "15220471", "url": "https://glygen.org/publication/PubMed/15220471" }, { "database": "PubMed", "id": "16076959", "url": "https://glygen.org/publication/PubMed/16076959" }, { "database": "PubMed", "id": "17090532", "url": "https://glygen.org/publication/PubMed/17090532" }, { "database": "PubMed", "id": "20519497", "url": "https://glygen.org/publication/PubMed/20519497" } ] }, { "sequence_org": "K", "sequence_mut": "R", "comment": "Reduced acetylation and transcriptional activity increased by about 1.5-fold. Completely abolishes acetylation, increases interaction with CEBPA and transcriptional activity increased by about 3-fold; when associated with R-242 and R-262. Transcriptional activity not inhibited by FCOR; when associated with R-242; R-259; R-262; R-271 and R-291. Predominantly nuclear and translocates to the cytoplasm on insulin-stimulation. No change on the inhibitory effect of oxidative stress on insulin-induced phosphorylations, but no inhibition of these phosphorylations by resveratrol; when associated with R-219; R-242; R-259; R-262; R-271 and R-291. 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Decreased DNA-binding by about half and enhanced phosphorylation by PKB/AKT1, no effect on interaction with CEBPA; when associated with either A-242 or Q-242 and either A-245 or Q-245. Cytoplasmic location in absence or presence of insulin, no change on the inhibitory effect of oxidative stress on insulin-induced phosphorylations, but no inhibition of these phosphorylations by resveratrol; when associated with Q-219; Q-242; Q-245; Q-259; Q-271 and Q-291. 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Decreased DNA-binding by about half and enhanced phosphorylation by PKB/AKT1, no effect on interaction with CEBPA; when associated with either A-242 or Q-242 and either A-245 or Q-245. Cytoplasmic location in absence or presence of insulin, no change on the inhibitory effect of oxidative stress on insulin-induced phosphorylations, but no inhibition of these phosphorylations by resveratrol; when associated with Q-219; Q-242; Q-245; Q-259; Q-271 and Q-291. 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promotes survival.", "journal": "Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology", "date": "2003", "authors": "Moller C, Xiang Z, Nilsson G", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "12911789", "url": "https://glygen.org/publication/PubMed/12911789" } ] }, { "title": "Exposure to asphalt fumes activates activator protein-1 through the phosphatidylinositol 3-kinase/Akt signaling pathway in mouse epidermal cells.", "journal": "The Journal of biological chemistry", "date": "2003-11-07", "authors": "Ma Cuiling, Wang Jin, Luo Jia", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "12947100", "url": "https://glygen.org/publication/PubMed/12947100" } ] }, { "title": "Akt activation in platelets depends on Gi signaling pathways.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Kim S, Jin J, Kunapuli SP", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "14623889", "url": "https://glygen.org/publication/PubMed/14623889" } ] }, { "title": "Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion markers in CD-1 mouse skin by oleandrin.", "journal": "Toxicology and applied pharmacology", "date": "2004-03-15", "authors": "Afaq Farrukh, Saleem Mohammad, Aziz Moammir Hasan, Mukhtar Hasan", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "15020199", "url": "https://glygen.org/publication/PubMed/15020199" } ] }, { "title": "Distinct activation mechanisms of protein kinase B by growth-factor stimulation and heat-shock treatment.", "journal": "Biochemistry", "date": "2004", "authors": "Matsuzaki H, Yamamoto T, Kikkawa U", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "15065872", "url": "https://glygen.org/publication/PubMed/15065872" } ] }, { "title": "PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells.", "journal": "The Journal of cell biology", "date": "2004", "authors": "Li J, Chen H, Tang MS, Shi X, Amin S, Desai D, Costa M, Huang C", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "15067018", "url": "https://glygen.org/publication/PubMed/15067018" } ] }, { "title": "Lupeol modulates NF-kappaB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice.", "journal": "Oncogene", "date": "2004", "authors": "Saleem M, Afaq F, Adhami VM, Mukhtar H", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "15122342", "url": "https://glygen.org/publication/PubMed/15122342" } ] }, { "title": "Phosphatidylinositol 3-kinase and Akt participate in the FSH-induced meiotic maturation of mouse oocytes.", "journal": "Molecular reproduction and development", "date": "2004", "authors": "Hoshino Y, Yokoo M, Yoshida N, Sasada H, Matsumoto H, Sato E", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "15278907", "url": "https://glygen.org/publication/PubMed/15278907" } ] }, { "title": "Activation of Akt/PDK signaling in macrophages upon binding of receptor-recognized forms of alpha2-macroglobulin to its cellular receptor: effect of silencing the CREB gene.", "journal": "Journal of cellular biochemistry", "date": "2004", "authors": "Misra UK, Pizzo SV", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "15389876", "url": "https://glygen.org/publication/PubMed/15389876" } ] }, { "title": "Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Le XF, Lammayot A, Gold D, Lu Y, Mao W, Chang T, Patel A, Mills GB, Bast RC Jr", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "15504738", "url": "https://glygen.org/publication/PubMed/15504738" } ] }, { "title": "Oral consumption of green tea polyphenols inhibits insulin-like growth factor-I-induced signaling in an autochthonous mouse model of prostate cancer.", "journal": "Cancer research", "date": "2004", "authors": "Adhami VM, Siddiqui IA, Ahmad N, Gupta S, Mukhtar H", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "15574782", "url": "https://glygen.org/publication/PubMed/15574782" } ] }, { "title": "Akt mediates the cross-talk between beta-adrenergic and insulin receptors in neonatal cardiomyocytes.", "journal": "Circulation research", "date": "2005", "authors": "Morisco C, Condorelli G, Trimarco V, Bellis A, Marrone C, Condorelli G, Sadoshima J, Trimarco B", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "15591229", "url": "https://glygen.org/publication/PubMed/15591229" } ] }, { "title": "PKB/AKT is involved in resumption of meiosis in mouse oocytes.", "journal": "Biology of the cell", "date": "2006", "authors": "Kalous J, Solc P, Baran V, Kubelka M, Schultz RM, Motlik J", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "15842198", "url": "https://glygen.org/publication/PubMed/15842198" } ] }, { "title": "A high inorganic phosphate diet perturbs brain growth, alters Akt-ERK signaling, and results in changes in cap-dependent translation.", "journal": "Toxicological sciences : an official journal of the Society of Toxicology", "date": "2006-03", "authors": "Jin Hua, Hwang Soon-Kyung, Yu Kyungnam, Anderson Hanjo K, Lee Yeon-Sook, Lee Kee Ho, Prats Anne-Catherine, Morello Dominique, Beck George R, Cho Myung-Haing", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "16338957", "url": "https://glygen.org/publication/PubMed/16338957" } ] }, { "title": "VEGF is upregulated by hypoxia-induced mitogenic factor via the PI-3K/Akt-NF-kappaB signaling pathway.", "journal": "Respiratory research", "date": "2006", "authors": "Tong Q, Zheng L, Lin L, Li B, Wang D, Huang C, Li D", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "16512910", "url": "https://glygen.org/publication/PubMed/16512910" } ] }, { "title": "Modulation of the PI 3-kinase-Akt signalling pathway by IGF-I and PTEN regulates the differentiation of neural stem/precursor cells.", "journal": "Journal of cell science", "date": "2006", "authors": "Otaegi G, Yusta-Boyo MJ, Vergano-Vera E, Mendez-Gomez HR, Carrera AC, Abad JL, Gonzalez M, de la Rosa EJ, Vicario-Abejon C, de Pablo F", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "16787946", "url": "https://glygen.org/publication/PubMed/16787946" } ] }, { "title": "Increased submaximal insulin-stimulated glucose uptake in mouse skeletal muscle after treadmill exercise.", "journal": "Journal of applied physiology (Bethesda, Md. : 1985)", "date": "2006-11", "authors": "Hamada Taku, Arias Edward B, Cartee Gregory D", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "16809629", "url": "https://glygen.org/publication/PubMed/16809629" } ] }, { "title": "Participation of the PI-3K/Akt-NF-kappa B signaling pathways in hypoxia-induced mitogenic factor-stimulated Flk-1 expression in endothelial cells.", "journal": "Respiratory research", "date": "2006", "authors": "Tong Q, Zheng L, Lin L, Li B, Wang D, Huang C, Matuschak GM, Li D", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "16872509", "url": "https://glygen.org/publication/PubMed/16872509" } ] }, { "title": "An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response.", "journal": "The Journal of experimental medicine", "date": "2007", "authors": "Liu Y, Zhu M, Nishida K, Hirano T, Zhang W", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "17190838", "url": "https://glygen.org/publication/PubMed/17190838" } ] }, { "title": "Leishmania donovani-induced ceramide as the key mediator of Akt dephosphorylation in murine macrophages: role of protein kinase Czeta and phosphatase.", "journal": "Infection and immunity", "date": "2007", "authors": "Dey R, Majumder N, Bhattacharjee S, Majumdar SB, Banerjee R, Ganguly S, Das P, Majumdar S", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "17220321", "url": "https://glygen.org/publication/PubMed/17220321" } ] }, { "title": "Ca2+/calmodulin-dependent protein kinase kinase-alpha regulates skeletal muscle glucose uptake independent of AMP-activated protein kinase and Akt activation.", "journal": "Diabetes", "date": "2007", "authors": "Witczak CA, Fujii N, Hirshman MF, Goodyear LJ", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "17287469", "url": "https://glygen.org/publication/PubMed/17287469" } ] }, { "title": "Endothelial dysfunction and compromised eNOS/Akt signaling in the thoracic aorta during the progression of Marfan syndrome.", "journal": "British journal of pharmacology", "date": "2007", "authors": "Chung AW, Au Yeung K, Cortes SF, Sandor GG, Judge DP, Dietz HC, van Breemen C", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "17339838", "url": "https://glygen.org/publication/PubMed/17339838" } ] }, { "title": "Essential role of PDK1 in regulating endothelial cell migration.", "journal": "The Journal of cell biology", "date": "2007", "authors": "Primo L, di Blasio L, Roca C, Droetto S, Piva R, Schaffhausen B, Bussolino F", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "17371830", "url": "https://glygen.org/publication/PubMed/17371830" } ] }, { "title": "Temporal changes in myocardial salvage kinases during reperfusion following ischemia: studies involving the cardioprotective adipocytokine apelin.", "journal": "Cardiovascular drugs and therapy", "date": "2007", "authors": "Smith CC, Mocanu MM, Bowen J, Wynne AM, Simpkin JC, Dixon RA, Cooper MB, Yellon DM", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "17924178", "url": "https://glygen.org/publication/PubMed/17924178" } ] }, { "title": "Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity.", "journal": "Molecular and cellular biology", "date": "2008", "authors": "Kumar A, Harris TE, Keller SR, Choi KM, Magnuson MA, Lawrence JC Jr", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "17967879", "url": "https://glygen.org/publication/PubMed/17967879" } ] }, { "title": "Luteolin suppresses inflammation-associated gene expression by blocking NF-kappaB and AP-1 activation pathway in mouse alveolar macrophages.", "journal": "Life sciences", "date": "2007-11-30", "authors": "Chen Chiu-Yuan, Peng Wen-Huang, Tsai Kuen-Daw, Hsu Shih-Lan", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "17977562", "url": "https://glygen.org/publication/PubMed/17977562" } ] }, { "title": "Silencing of GM3 synthase suppresses lung metastasis of murine breast cancer cells.", "journal": "Breast cancer research : BCR", "date": "2008", "authors": "Gu Y, Zhang J, Mi W, Yang J, Han F, Lu X, Yu W", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "18171481", "url": "https://glygen.org/publication/PubMed/18171481" } ] }, { "title": "Protein kinase B (PKB/Akt) is required for the completion of meiosis in mouse oocytes.", "journal": "Developmental biology", "date": "2008", "authors": "Hoshino Y, Sato E", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "18177853", "url": "https://glygen.org/publication/PubMed/18177853" } ] }, { "title": "Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage.", "journal": "The Journal of cell biology", "date": "2008-03-10", "authors": "Wang Hao-Ven, Chang Ling-Wei, Brixius Klara, Wickstr\u00f6m Sara A, Montanez Eloi, Thievessen Ingo, Schwander Martin, M\u00fcller Ulrich, Bloch Wilhelm, Mayer Ulrike, F\u00e4ssler Reinhard", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "18332223", "url": "https://glygen.org/publication/PubMed/18332223" } ] }, { "title": "In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Surucu B, Bozulic L, Hynx D, Parcellier A, Hemmings BA", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "18757368", "url": "https://glygen.org/publication/PubMed/18757368" } ] }, { "title": "Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues.", "journal": "Diabetes", "date": "2009", "authors": "Wang H, Knaub LA, Jensen DR, Young Jung D, Hong EG, Ko HJ, Coates AM, Goldberg IJ, de la Houssaye BA, Janssen RC, McCurdy CE, Rahman SM, Soo Choi C, Shulman GI, Kim JK, Friedman JE, Eckel RH", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "18952837", "url": "https://glygen.org/publication/PubMed/18952837" } ] }, { "title": "Protein kinase C theta (PKCtheta)-dependent phosphorylation of PDK1 at Ser504 and Ser532 contributes to palmitate-induced insulin resistance.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Wang C, Liu M, Riojas RA, Xin X, Gao Z, Zeng R, Wu J, Dong LQ, Liu F", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "19047061", "url": "https://glygen.org/publication/PubMed/19047061" } ] }, { "title": "The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation.", "journal": "Hepatology (Baltimore, Md.)", "date": "2009", "authors": "Haga S, Ozaki M, Inoue H, Okamoto Y, Ogawa W, Takeda K, Akira S, Todo S", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "19065678", "url": "https://glygen.org/publication/PubMed/19065678" } ] }, { "title": "Lipocalin 2 promotes lung metastasis of murine breast cancer cells.", "journal": "Journal of experimental & clinical cancer research : CR", "date": "2008", "authors": "Shi H, Gu Y, Yang J, Xu L, Mi W, Yu W", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "19077278", "url": "https://glygen.org/publication/PubMed/19077278" } ] }, { "title": "Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity.", "journal": "The EMBO journal", "date": "2009", "authors": "Cao J, Schulte J, Knight A, Leslie NR, Zagozdzon A, Bronson R, Manevich Y, Beeson C, Neumann CA", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "19369943", "url": "https://glygen.org/publication/PubMed/19369943" } ] }, { "title": "MP470, a novel receptor tyrosine kinase inhibitor, in combination with Erlotinib inhibits the HER family/PI3K/Akt pathway and tumor growth in prostate cancer.", "journal": "BMC cancer", "date": "2009", "authors": "Qi W, Cooke LS, Stejskal A, Riley C, Croce KD, Saldanha JW, Bearss D, Mahadevan D", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "19432987", "url": "https://glygen.org/publication/PubMed/19432987" } ] }, { "title": "Oocyte-specific deletion of Pten in mice reveals a stage-specific function of PTEN/PI3K signaling in oocytes in controlling follicular 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{ "title": "Notch signaling regulates the phosphorylation of Akt and survival of lipopolysaccharide-activated macrophages via regulator of G protein signaling 19 (RGS19).", "journal": "Immunobiology", "date": "2014", "authors": "Sangphech N, Osborne BA, Palaga T", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "24775271", "url": "https://glygen.org/publication/PubMed/24775271" } ] }, { "title": "Rapamycin reverses insulin resistance (IR) in high-glucose medium without causing IR in normoglycemic medium.", "journal": "Cell death & disease", "date": "2014", "authors": "Leontieva OV, Demidenko ZN, Blagosklonny MV", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "24810050", "url": "https://glygen.org/publication/PubMed/24810050" } ] }, { "title": 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"iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "27994061", "url": "https://glygen.org/publication/PubMed/27994061" } ] }, { "title": "The GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation.", "journal": "The Journal of biological chemistry", "date": "2020", "authors": "Kowalsky AH, Namkoong S, Mettetal E, Park HW, Kazyken D, Fingar DC, Lee JH", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "31915252", "url": "https://glygen.org/publication/PubMed/31915252" } ] }, { "title": "The B cell antigen receptor activates the Akt (protein kinase B)/glycogen synthase kinase-3 signaling pathway via phosphatidylinositol 3-kinase.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "1999", "authors": "Gold MR, Scheid MP, Santos L, Dang-Lawson M, Roth RA, Matsuuchi L, Duronio V, Krebs DL", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "10438924", "url": "https://glygen.org/publication/PubMed/10438924" } ] }, { "title": "Protein kinase C-alpha overexpression stimulates Akt activity and suppresses apoptosis induced by interleukin 3 withdrawal.", "journal": "Oncogene", "date": "1999", "authors": "Li W, Zhang J, Flechner L, Hyun T, Yam A, Franke TF, Pierce JH", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "10597260", "url": "https://glygen.org/publication/PubMed/10597260" } ] }, { "title": "Cooperative effect of hepatocyte growth factor and fibronectin in anchorage-independent survival of mammary carcinoma cells: requirement for phosphatidylinositol 3-kinase activity.", "journal": "Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research", "date": "2000", "authors": "Qiao H, Saulnier R, Patryzkat A, Rahimi N, Raptis L, Rossiter J, Tremblay E, Elliott B", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "10714768", "url": "https://glygen.org/publication/PubMed/10714768" } ] }, { "title": "Increased insulin receptor substrate-1 and enhanced skeletal muscle insulin sensitivity in mice lacking CCAAT/enhancer-binding protein beta.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Wang L, Shao J, Muhlenkamp P, Liu S, Klepcyk P, Ren J, Friedman JE", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "10747954", "url": "https://glygen.org/publication/PubMed/10747954" } ] }, { "title": "Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo.", "journal": "The Journal of experimental medicine", "date": "2000", "authors": "Jones RG, Parsons M, Bonnard M, Chan VS, Yeh WC, Woodgett JR, Ohashi PS", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "10811865", "url": "https://glygen.org/publication/PubMed/10811865" } ] }, { "title": "Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Bakin AV, Tomlinson AK, Bhowmick NA, Moses HL, Arteaga CL", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": 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"id": "11062251", "url": "https://glygen.org/publication/PubMed/11062251" } ] }, { "title": "UV Induces phosphorylation of protein kinase B (Akt) at Ser-473 and Thr-308 in mouse epidermal Cl 41 cells through hydrogen peroxide.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Huang C, Li J, Ding M, Leonard SS, Wang L, Castranova V, Vallyathan V, Shi X", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "11507090", "url": "https://glygen.org/publication/PubMed/11507090" } ] }, { "title": "Tumour necrosis factor-alpha activation of protein kinase B in WEHI-164 cells is accompanied by increased phosphorylation of Ser473, but not Thr308.", "journal": "The Biochemical journal", "date": "2001", "authors": "O'toole A, Moule SK, Lockyer PJ, Halestrap AP", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": 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"http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "12464394", "url": "https://glygen.org/publication/PubMed/12464394" } ] }, { "title": "Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Wick KR, Werner ED, Langlais P, Ramos FJ, Dong LQ, Shoelson SE, Liu F", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "12493740", "url": "https://glygen.org/publication/PubMed/12493740" } ] }, { "title": "Arsenite-induced phosphorylation of histone H3 at serine 10 is mediated by Akt1, extracellular signal-regulated kinase 2, and p90 ribosomal S6 kinase 2 but not mitogen- and stress-activated protein kinase 1.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "He Z, Ma WY, Liu G, Zhang Y, Bode AM, Dong Z", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "12529330", "url": "https://glygen.org/publication/PubMed/12529330" } ] }, { "title": "PI3-K/Akt pathway contributes to IL-6-dependent growth of 7TD1 cells.", "journal": "Cancer cell international", "date": "2003", "authors": "Zhang J, Li Y, Shen B", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "12633505", "url": "https://glygen.org/publication/PubMed/12633505" } ] }, { "title": "Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Pankov R, Cukierman E, Clark K, Matsumoto K, Hahn C, Poulin B, Yamada KM", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "12637511", "url": "https://glygen.org/publication/PubMed/12637511" } ] }, { "title": "Age-related differences in the des IGF-I-mediated activation of Akt-1 and p70 S6K in mouse skeletal muscle.", "journal": "Mechanisms of ageing and development", "date": "2003", "authors": "Li M, Li C, Parkhouse WS", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "12875741", "url": "https://glygen.org/publication/PubMed/12875741" } ] }, { "title": "Activation of mast cells by immunoglobulin E-receptor cross-linkage, but not through adenosine receptors, induces A1 expression and promotes survival.", "journal": "Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology", "date": "2003", "authors": "Moller C, Xiang Z, Nilsson G", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "12911789", "url": "https://glygen.org/publication/PubMed/12911789" } ] }, { "title": "Exposure to asphalt fumes activates activator protein-1 through the phosphatidylinositol 3-kinase/Akt signaling pathway in mouse epidermal cells.", "journal": "The Journal of biological chemistry", "date": "2003-11-07", "authors": "Ma Cuiling, Wang Jin, Luo Jia", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "12947100", "url": "https://glygen.org/publication/PubMed/12947100" } ] }, { "title": "Immune evasion by murine melanoma mediated through CC chemokine receptor-10.", "journal": "The Journal of experimental medicine", "date": "2003", "authors": "Murakami T, Cardones AR, Finkelstein SE, Restifo NP, Klaunberg BA, Nestle FO, Castillo SS, Dennis PA, Hwang ST", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "14581607", "url": "https://glygen.org/publication/PubMed/14581607" } ] }, { "title": "Levels of PTEN protein modulate Akt phosphorylation on serine 473, but not on threonine 308, in IGF-II-overexpressing rhabdomyosarcomas cells.", "journal": "Oncogene", "date": "2003", "authors": "Wan X, Helman LJ", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "14603261", "url": "https://glygen.org/publication/PubMed/14603261" } ] }, { "title": "Akt activation in platelets depends on Gi signaling pathways.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Kim S, Jin J, Kunapuli SP", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "14623889", "url": "https://glygen.org/publication/PubMed/14623889" } ] }, { "title": "S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR).", "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology", "date": "2004", "authors": "Baudhuin LM, Jiang Y, Zaslavsky A, Ishii I, Chun J, Xu Y", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "14657000", "url": "https://glygen.org/publication/PubMed/14657000" } ] }, { "title": "Specific roles for the PI3K and the MEK-ERK pathway in IGF-1-stimulated chemotaxis, VEGF secretion and proliferation of multiple myeloma cells: study in the 5T33MM model.", "journal": "British journal of cancer", "date": "2004-03-08", "authors": "Menu E, Kooijman R, Van Valckenborgh E, Asosingh K, Bakkus M, Van Camp B, Vanderkerken K", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "14997210", "url": "https://glygen.org/publication/PubMed/14997210" } ] }, { "title": "PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells.", "journal": "The Journal of cell biology", "date": "2004", "authors": "Li J, Chen H, Tang MS, Shi X, Amin S, Desai D, Costa M, Huang C", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "15067018", "url": "https://glygen.org/publication/PubMed/15067018" } ] }, { "title": "Translation of the radioresistance kinase TLK1B is induced by gamma-irradiation through activation of mTOR and phosphorylation of 4E-BP1.", "journal": "BMC molecular biology", "date": "2004", "authors": "Sunavala-Dossabhoy G, Fowler M, De Benedetti A", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "15070431", "url": "https://glygen.org/publication/PubMed/15070431" } ] }, { "title": "Phosphatidylinositol 3-kinase and Akt participate in the FSH-induced meiotic maturation of mouse oocytes.", "journal": "Molecular reproduction and development", "date": "2004", "authors": "Hoshino Y, Yokoo M, Yoshida N, Sasada H, Matsumoto H, Sato E", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "15278907", "url": "https://glygen.org/publication/PubMed/15278907" } ] }, { "title": "Activation of Akt/PDK signaling in macrophages upon binding of receptor-recognized forms of alpha2-macroglobulin to its cellular receptor: effect of silencing the CREB gene.", "journal": "Journal of cellular biochemistry", "date": "2004", "authors": "Misra UK, Pizzo SV", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "15389876", "url": "https://glygen.org/publication/PubMed/15389876" } ] }, { "title": "Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Le XF, Lammayot A, Gold D, Lu Y, Mao W, Chang T, Patel A, Mills GB, Bast RC Jr", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "15504738", "url": "https://glygen.org/publication/PubMed/15504738" } ] }, { "title": "Impairment of PI3-K/Akt pathway underlies attenuated endothelial function in aorta of type 2 diabetic mouse model.", "journal": "Hypertension (Dallas, Tex. : 1979)", "date": "2004", "authors": "Kobayashi T, Taguchi K, Yasuhiro T, Matsumoto T, Kamata K", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "15505117", "url": "https://glygen.org/publication/PubMed/15505117" } ] }, { "title": "Activated Akt-1 in specific cell populations during multi-stage skin carcinogenesis.", "journal": "Anticancer research", "date": "2004", "authors": "Affara NI, Schanbacher BL, Mihm MJ, Cook AC, Pei P, Mallery SR, Trempus CS, Bauer JA, Robertson FM", "evidence": [ { 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{ "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "15591229", "url": "https://glygen.org/publication/PubMed/15591229" } ] }, { "title": "Angiopoietin-1 promotes cardiac and skeletal myocyte survival through integrins.", "journal": "Circulation research", "date": "2005-03-04", "authors": "Dallabrida Susan M, Ismail Nesreen, Oberle Julianne R, Himes Blanca E, Rupnick Maria A", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "15692086", "url": "https://glygen.org/publication/PubMed/15692086" } ] }, { "title": "PKB/AKT is involved in resumption of meiosis in mouse oocytes.", "journal": "Biology of the cell", "date": "2006", "authors": "Kalous J, Solc P, Baran V, Kubelka M, Schultz RM, Motlik J", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": 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Katia, St-Arnaud Rene, Force Thomas, Dedhar Shoukat, Gerszten Robert E", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "16314534", "url": "https://glygen.org/publication/PubMed/16314534" } ] }, { "title": "Protein kinase C negatively regulates Akt activity and modifies UVC-induced apoptosis in mouse keratinocytes.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Li L, Sampat K, Hu N, Zakari J, Yuspa SH", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "16338928", "url": "https://glygen.org/publication/PubMed/16338928" } ] }, { "title": "A high inorganic phosphate diet perturbs brain growth, alters Akt-ERK signaling, and results in changes in cap-dependent translation.", "journal": "Toxicological sciences : an 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mechanism.", "journal": "Cardiovascular research", "date": "2006-09-01", "authors": "Jin Zhu-Qiu, Karliner Joel S", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "16831409", "url": "https://glygen.org/publication/PubMed/16831409" } ] }, { "title": "Inhibitory effect of antipsychotic drugs on the Con A- and LPS-induced proliferative activity of mouse splenocytes: a possible mechanism of action.", "journal": "Journal of physiology and pharmacology : an official journal of the Polish Physiological Society", "date": "2006", "authors": "Basta-Kaim A, Budziszewska B, Jagla G, Nowak W, Kubera M, Lason W", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "16845229", "url": "https://glygen.org/publication/PubMed/16845229" } ] }, { "title": 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Bloch Wilhelm, Mayer Ulrike, F\u00e4ssler Reinhard", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "18332223", "url": "https://glygen.org/publication/PubMed/18332223" } ] }, { "title": "A dual-color fluorescence-based platform to identify selective inhibitors of Akt signaling.", "journal": "PloS one", "date": "2008-03-19", "authors": "Rosado Aranzaz\u00fa, Zanella Fabian, Garcia Beatriz, Carnero Amancio, Link Wolfgang", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "18350159", "url": "https://glygen.org/publication/PubMed/18350159" } ] }, { "title": "Possible involvement of Akt activity in endothelial dysfunction in type 2 diabetic mice.", "journal": "Journal of pharmacological sciences", "date": "2008", "authors": "Takenouchi Y, Kobayashi 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Research Society and the International IGF Research Society", "date": "2010", "authors": "Miquet JG, Munoz MC, Giani JF, Gonzalez L, Dominici FP, Bartke A, Turyn D, Sotelo AI", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "20022531", "url": "https://glygen.org/publication/PubMed/20022531" } ] }, { "title": "Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice.", "journal": "Diabetes", "date": "2010", "authors": "Gonzalez-Rodriguez A, Mas Gutierrez JA, Sanz-Gonzalez S, Ros M, Burks DJ, Valverde AM", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "20028942", "url": "https://glygen.org/publication/PubMed/20028942" } ] }, { "title": "Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in 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"2011", "authors": "Hsing CH, Lin MC, Choi PC, Huang WC, Kai JI, Tsai CC, Cheng YL, Hsieh CY, Wang CY, Chang YP, Chen YH, Chen CL, Lin CF", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "21408125", "url": "https://glygen.org/publication/PubMed/21408125" } ] }, { "title": "A novel small molecule antagonist of choline kinase-alpha that simultaneously suppresses MAPK and PI3K/AKT signaling.", "journal": "Oncogene", "date": "2011", "authors": "Clem BF, Clem AL, Yalcin A, Goswami U, Arumugam S, Telang S, Trent JO, Chesney J", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "21423211", "url": "https://glygen.org/publication/PubMed/21423211" } ] }, { "title": "Tuberous sclerosis complex-1 deficiency attenuates diet-induced hepatic lipid accumulation.", "journal": "PloS one", "date": "2011", "authors": "Kenerson HL, Yeh MM, Yeung RS", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "21479224", "url": "https://glygen.org/publication/PubMed/21479224" } ] }, { "title": "Emerging role of Akt substrate protein AS160 in the regulation of AQP2 translocation.", "journal": "American journal of physiology. 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{ "title": "MK2 Is Required for Neutrophil-Derived ROS Production and Inflammatory Bowel Disease.", "journal": "Frontiers in medicine", "date": "2020", "authors": "Zhang Tao, Jiang Junhang, Liu Jingting, Xu Lu, Duan Shixin, Sun Lei, Zhao Wenjuan, Qian Feng", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "32596245", "url": "https://glygen.org/publication/PubMed/32596245" } ] }, { "title": "The Role of PI3K/AKT Pathway and NADPH Oxidase 4 in Host ROS Manipulation by Toxoplasma gondii.", "journal": "The Korean journal of parasitology", "date": "2020-06", "authors": "Choi Hei Gwon, Gao Fei-Fei, Zhou Wei, Sun Pu-Reum, Yuk Jae-Min, Lee Young-Ha, Cha Guang-Ho", "evidence": [ { "database": "iPTMnet", "id": "P31750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31750" } ], "reference": [ { "type": "PubMed", "id": "32615737", "url": 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