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CG18069; Ca2+/calmodulin-dependent protein kinase II; CaM II; CaM KII; CaM kinase; CaMK II; CaMK-II; CaMKII; CaMKii; CaM; Calcium/calmodulin-dependent protein kinase; CamK-II; CamKIIalpha; CamKII; Camkii; Cam; DCK; Dmel\\CG18069; calcium/calmodulin-dependent protein kinase II; camKII; camk II; camkII; camkii; dCAMKII; dCaMKII; l(4)102EFb; l(4)16; l(4)ar", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q00168", "url": "https://www.uniprot.org/uniprotkb/Q00168" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [], "crossref": [ { "id": "GLY_001163", "url": "https://data.glygen.org/GLY_001163", "database": "GlyGen", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "DFGLAIEVQGDHQAWFGFAG", "down_seq": "PGYLSPEVLKKEPYGKSVDI", "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", 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CaMKii; CaM; CamK-II; CamKIIalpha; CamKII; Camkii; Cam; DCK; Dmel\\CG18069; Dmel_CG18069; camKII; camk II; camkII; camkii; dCAMKII; dCaMKII; l(4)102EFb; l(4)16; l(4)ar", "gene_names_refseq": "CAMKIIalpha; CAMKIId; CAMKII; CDPK1; CG18069; Ca2+/calmodulin-dependent protein kinase II; CaM II; CaM KII; CaM kinase; CaMK II; CaMK-II; CaMKII; CaMKii; CaM; Calcium/calmodulin-dependent protein kinase; CamK-II; CamKIIalpha; CamKII; Camkii; Cam; DCK; Dmel\\CG18069; calcium/calmodulin-dependent protein kinase II; camKII; camk II; camkII; camkii; dCAMKII; dCaMKII; l(4)102EFb; l(4)16; l(4)ar", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q00168", "url": "https://www.uniprot.org/uniprotkb/Q00168" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [ { "title": "Regulation of the Ca2+/CaM-responsive pool of CaMKII by scaffold-dependent autophosphorylation.", "journal": "Neuron", "date": "2003", "authors": "Lu CS, Hodge JJ, Mehren J, Sun XX, Griffith LC", "evidence": [ { "database": "UniProtKB", "id": "Q00168", "url": "https://www.uniprot.org/uniprotkb/Q00168" }, { "database": "iPTMnet", "id": "Q00168", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00168" } ], "reference": [ { "type": "PubMed", "id": "14687552", "url": "https://glygen.org/publication/PubMed/14687552" } ] }, { "title": "Activity-dependent gating of CaMKII autonomous activity by Drosophila CASK.", "journal": "Neuron", "date": "2006", "authors": "Hodge JJ, Mullasseril P, Griffith LC", "evidence": [ { "database": "UniProtKB", "id": "Q00168", "url": "https://www.uniprot.org/uniprotkb/Q00168" }, { "database": "iPTMnet", "id": "Q00168", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00168" } ], "reference": [ { "type": "PubMed", "id": "16880127", "url": "https://glygen.org/publication/PubMed/16880127" } ] }, { "title": "CASK and CaMKII function in the mushroom body alpha'/beta' neurons during Drosophila memory formation.", "journal": "Frontiers in neural circuits", "date": "2013", "authors": "Malik BR, Gillespie JM, Hodge JJ", "evidence": [ { "database": "iPTMnet", "id": "Q00168", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00168" } ], "reference": [ { "type": "PubMed", "id": "23543616", "url": "https://glygen.org/publication/PubMed/23543616" } ] }, { "title": "Aging and CaMKII alter intracellular Ca2+ transients and heart rhythm in Drosophila melanogaster.", "journal": "PloS one", "date": "2014", "authors": "Santalla M, Valverde CA, Harnichar E, Lacunza E, Aguilar-Fuentes J, Mattiazzi A, Ferrero P", "evidence": [ { "database": "iPTMnet", "id": "Q00168", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00168" } ], "reference": [ { "type": "PubMed", "id": "25003749", "url": "https://glygen.org/publication/PubMed/25003749" } ] } ], "crossref": [ { "id": "Q00168", "url": "https://www.uniprot.org/uniprotkb/Q00168", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "14687552", "url": "https://glygen.org/publication/PubMed/14687552", "database": "PubMed", "categories": [ "Other" ] }, { "id": "Q00168", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q00168", "database": "iPTMnet", "categories": [ "Other" ] }, { "id": "16880127", "url": "https://glygen.org/publication/PubMed/16880127", "database": "PubMed", "categories": [ "Other" ] }, { "id": "23543616", "url": "https://glygen.org/publication/PubMed/23543616", "database": "PubMed", "categories": [ "Other" ] }, { "id": "25003749", "url": "https://glygen.org/publication/PubMed/25003749", "database": "PubMed", "categories": [ "Other" ] } ], "site_seq": "T", "start_aa": "T", "up_seq": "ETVDCLKKFNARRKLKGAIL", "down_seq": "TMLATRNFSSRSMITKKGEG", "mutagenesis": [ { "sequence_org": "T", "sequence_mut": "A", "comment": "Fails to interact with CASK, catalytically active but fails to autophosphorylate, when associated with A-307.", "evidence": [ { "database": "UniProtKB", "id": "Q00168", "url": "https://www.uniprot.org/uniprotkb/Q00168" }, { "database": "PubMed", "id": "14687552", "url": "https://glygen.org/publication/PubMed/14687552" } ] }, { "sequence_org": "T", "sequence_mut": "D", "comment": "Fails to interact with CASK, kinase inactive, when associated with D-307.", "evidence": [ { "database": "UniProtKB", "id": "Q00168", "url": "https://www.uniprot.org/uniprotkb/Q00168" }, { "database": "PubMed", "id": "14687552", "url": "https://glygen.org/publication/PubMed/14687552" } ] }, { "sequence_org": "T", "sequence_mut": "S", "comment": "Fails to interact with CASK, catalytically active and can autophosphorylate, when associated with S-307.", "evidence": [ { "database": "UniProtKB", "id": "Q00168", "url": "https://www.uniprot.org/uniprotkb/Q00168" }, { "database": "PubMed", "id": "14687552", "url": "https://glygen.org/publication/PubMed/14687552" } ] } ], 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"sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00168-1.307.307", "start_pos": 307, "end_pos": 307, "uniprot_canonical_ac": "Q00168-1", "length": 530, "uniprot_id": "KCC2A_DROME", "protein_name": "Calcium/calmodulin-dependent protein kinase type II alpha chain", "refseq_ac": "NP_001014696", "refseq_name": "Calcium/calmodulin-dependent protein kinase II, isoform G", "gene_name": "CaMKII", "gene_names_uniprotkb": "CaMKII; CAMKIIalpha; CAMKIId; CAMKII; CDPK1; CG18069; CaM II; CaM KII; CaM kinase; CaMK II; CaMK-II; CaMKii; CaM; CamK-II; CamKIIalpha; CamKII; Camkii; Cam; DCK; Dmel\\CG18069; Dmel_CG18069; camKII; camk II; camkII; camkii; dCAMKII; dCaMKII; l(4)102EFb; l(4)16; l(4)ar", "gene_names_refseq": "CAMKIIalpha; CAMKIId; CAMKII; CDPK1; CG18069; 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0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "id": "Q00168-1.287.287", "start_pos": 287, "end_pos": 287, "uniprot_canonical_ac": "Q00168-1", "length": 530, "uniprot_id": "KCC2A_DROME", "protein_name": "Calcium/calmodulin-dependent protein kinase type II alpha chain", "refseq_ac": "NP_001014696", "refseq_name": "Calcium/calmodulin-dependent protein kinase II, isoform G", "gene_name": "CaMKII", "gene_names_uniprotkb": "CaMKII; CAMKIIalpha; CAMKIId; CAMKII; CDPK1; CG18069; CaM II; CaM KII; CaM kinase; CaMK II; CaMK-II; CaMKii; CaM; CamK-II; CamKIIalpha; CamKII; Camkii; Cam; DCK; Dmel\\CG18069; Dmel_CG18069; camKII; camk II; camkII; camkii; dCAMKII; dCaMKII; l(4)102EFb; l(4)16; l(4)ar", "gene_names_refseq": "CAMKIIalpha; CAMKIId; CAMKII; CDPK1; CG18069; Ca2+/calmodulin-dependent protein kinase II; CaM II; CaM KII; CaM kinase; CaMK II; CaMK-II; CaMKII; CaMKii; CaM; Calcium/calmodulin-dependent protein kinase; CamK-II; CamKIIalpha; CamKII; Camkii; Cam; DCK; Dmel\\CG18069; calcium/calmodulin-dependent protein kinase II; camKII; camk II; camkII; camkii; dCAMKII; dCaMKII; l(4)102EFb; l(4)16; l(4)ar", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q00168", "url": "https://www.uniprot.org/uniprotkb/Q00168" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "publication": [ { "title": "Regulation of the Ca2+/CaM-responsive pool of CaMKII by scaffold-dependent autophosphorylation.", "journal": "Neuron", "date": "2003", "authors": "Lu CS, Hodge JJ, Mehren J, Sun XX, Griffith LC", "evidence": [ { "database": "UniProtKB", "id": "Q00168", "url": "https://www.uniprot.org/uniprotkb/Q00168" }, { "database": "iPTMnet", 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