[ { "title": "Loss of function variants in L2HGDH gene causing L-2-hydroxyglutaric aciduria.", "journal": "Acta neurologica Belgica", "date": "2023-12", "authors": "Bellad Anikha, Holla Vikram V, Kumari Riyanka, Kamble Nitish, Yadav Ravi, Pandey Akhilesh, Pal Pramod Kumar, Muthusamy Babylakshmi", "reference": { "type": "PubMed", "id": "37378753", "url": "https://pubmed.ncbi.nlm.nih.gov/37378753" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9H9P8-1", "protein_name": "L-2-hydroxyglutarate dehydrogenase, mitochondrial", "gene_name": "L2HGDH", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9H9P8", "url": "https://www.uniprot.org/uniprotkb/Q9H9P8" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.37378753", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], 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"sequence_mut": "GS", "comment": "No effect on the interaction with MAP2K1, MAP2K2 and YWHAE. Abolishes interaction with BRAF. Abolishes location at membrane ruffles.", "evidence": [ { "database": "UniProtKB", "id": "Q61097", "url": "https://www.uniprot.org/uniprotkb/Q61097" }, { "database": "PubMed", "id": "23250398", "url": "https://pubmed.ncbi.nlm.nih.gov/23250398" }, { "database": "PubMed", "id": "10409742", "url": "https://pubmed.ncbi.nlm.nih.gov/10409742" } ], "uniprot_canonical_ac": "Q61097-1" }, { "start_pos": 580, "end_pos": 580, "sequence_org": "G", "sequence_mut": "E", "comment": "Partial decrease in MAP2K1 and MAP2K2 binding. No effect on the interaction with YWHAE.", "evidence": [ { "database": "UniProtKB", "id": "Q61097", "url": "https://www.uniprot.org/uniprotkb/Q61097" }, { "database": "PubMed", "id": "10409742", "url": "https://pubmed.ncbi.nlm.nih.gov/10409742" } ], "uniprot_canonical_ac": "Q61097-1" }, { "start_pos": 589, "end_pos": 589, "sequence_org": "R", "sequence_mut": "M", "comment": "Severe decrease in MAP2K1 and MAP2K2 binding. No effect on the interaction with YWHAE.", "evidence": [ { "database": "UniProtKB", "id": "Q61097", "url": "https://www.uniprot.org/uniprotkb/Q61097" }, { "database": "PubMed", "id": "10891492", "url": "https://pubmed.ncbi.nlm.nih.gov/10891492" }, { "database": "PubMed", "id": "10409742", "url": "https://pubmed.ncbi.nlm.nih.gov/10409742" } ], "uniprot_canonical_ac": "Q61097-1" }, { "start_pos": 615, "end_pos": 615, "sequence_org": "R", "sequence_mut": "H", "comment": "Severe decrease in MAP2K1 and MAP2K2 binding. No effect on the interaction with YWHAE.", "evidence": [ { "database": "UniProtKB", "id": "Q61097", "url": "https://www.uniprot.org/uniprotkb/Q61097" }, { "database": "PubMed", "id": "10891492", "url": "https://pubmed.ncbi.nlm.nih.gov/10891492" }, { "database": "PubMed", "id": "10409742", "url": "https://pubmed.ncbi.nlm.nih.gov/10409742" } ], "uniprot_canonical_ac": "Q61097-1" }, { "start_pos": 809, "end_pos": 809, "sequence_org": "C", "sequence_mut": "Y", "comment": "Associates almost exclusively with the membrane. Loss of MAP2K2 and MAP2K2 binding and recruitment to the membrane. Loss of MAP kinase-mediated inhibition of ELK1 phosphorylation. No effect on the interaction with YWHAE.", "evidence": [ { "database": "UniProtKB", "id": "Q61097", "url": "https://www.uniprot.org/uniprotkb/Q61097" }, { "database": "PubMed", "id": "10891492", "url": "https://pubmed.ncbi.nlm.nih.gov/10891492" }, { "database": "PubMed", "id": "10409742", "url": "https://pubmed.ncbi.nlm.nih.gov/10409742" } ], "uniprot_canonical_ac": "Q61097-1" } ], "record_id": "pubmed.10409742", "abstract": "", "glycosylation": [], "snv": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 48 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { 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"uniprot_canonical_ac": "P01111-1", "protein_name": "GTPase NRas", "gene_name": "NRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62834-1", "protein_name": "Ras-related protein Rap-1A", "gene_name": "RAP1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04275-1", "protein_name": "von Willebrand factor", "gene_name": "VWF", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18206-1", "protein_name": "Vinculin", "gene_name": "VCL", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30086-1", "protein_name": "Phosphatidylethanolamine-binding protein 1", "gene_name": "PEBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BRX9-1", "protein_name": "WD repeat domain-containing protein 83", "gene_name": "WDR83", "tax_name": "Human" }, { "uniprot_canonical_ac": "P41240-1", "protein_name": "Tyrosine-protein kinase CSK", "gene_name": "CSK", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08514-1", "protein_name": "Integrin alpha-IIb", "gene_name": "ITGA2B", "tax_name": 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"uniprot_canonical_ac": "Q8IVT5-1", "protein_name": "Kinase suppressor of Ras 1", "gene_name": "KSR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFM7-1", "protein_name": "Interleukin-17 receptor D", "gene_name": "IL17RD", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6VAB6-1", "protein_name": "Kinase suppressor of Ras 2", "gene_name": "KSR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27361-1", "protein_name": "Mitogen-activated protein kinase 3", "gene_name": "MAPK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8QHJ9-1", "protein_name": "Interleukin-17 receptor D", "gene_name": "il17rd", "tax_name": "Zebrafish" }, { "uniprot_canonical_ac": "P12931-1", "protein_name": "Proto-oncogene tyrosine-protein kinase Src", "gene_name": "SRC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7Z5R6-1", "protein_name": "Amyloid beta A4 precursor protein-binding family B member 1-interacting protein", "gene_name": "APBB1IP", "tax_name": "Human" }, { 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"glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling.", "journal": "Nature cell biology", "date": 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"uniprot_canonical_ac": "Q02750-1", "protein_name": "Dual specificity mitogen-activated protein kinase kinase 1", "gene_name": "MAP2K1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y2Q5-1", "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "LAMTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IVT5-1", "protein_name": "Kinase suppressor of Ras 1", "gene_name": "KSR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFM7-1", "protein_name": "Interleukin-17 receptor D", "gene_name": "IL17RD", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6VAB6-1", "protein_name": "Kinase suppressor of Ras 2", "gene_name": "KSR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27361-1", "protein_name": "Mitogen-activated protein kinase 3", "gene_name": "MAPK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12931-1", "protein_name": "Proto-oncogene tyrosine-protein kinase Src", "gene_name": "SRC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7Z5R6-1", 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"total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Regulation of Ras localization by acylation enables a mode of intracellular signal propagation.", "journal": "Science signaling", "date": "2010", "authors": "Lorentzen A, Kinkhabwala A, Rocks O, Vartak N, 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"Phosphatidylethanolamine-binding protein 1", "gene_name": "PEBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BRX9-1", "protein_name": "WD repeat domain-containing protein 83", "gene_name": "WDR83", "tax_name": "Human" }, { "uniprot_canonical_ac": "P41240-1", "protein_name": "Tyrosine-protein kinase CSK", "gene_name": "CSK", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08514-1", "protein_name": "Integrin alpha-IIb", "gene_name": "ITGA2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P32121-1", "protein_name": "Beta-arrestin-2", "gene_name": "ARRB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63261-1", "protein_name": "Actin, cytoplasmic 2", "gene_name": "ACTG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49407-1", "protein_name": "Beta-arrestin-1", "gene_name": "ARRB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q969H4-1", "protein_name": "Connector enhancer of kinase suppressor of ras 1", "gene_name": "CNKSR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WXI2-1", "protein_name": "Connector enhancer of kinase suppressor of ras 2", "gene_name": "CNKSR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02675-1", "protein_name": "Fibrinogen beta chain", "gene_name": "FGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05106-1", "protein_name": "Integrin beta-3", "gene_name": "ITGB3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q02750-1", "protein_name": "Dual specificity mitogen-activated protein kinase kinase 1", "gene_name": "MAP2K1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y2Q5-1", "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "LAMTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IVT5-1", "protein_name": "Kinase suppressor of Ras 1", "gene_name": "KSR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFM7-1", "protein_name": "Interleukin-17 receptor D", "gene_name": "IL17RD", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6VAB6-1", "protein_name": "Kinase suppressor of Ras 2", "gene_name": "KSR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27361-1", "protein_name": "Mitogen-activated protein kinase 3", "gene_name": "MAPK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12931-1", "protein_name": "Proto-oncogene tyrosine-protein kinase Src", "gene_name": "SRC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7Z5R6-1", "protein_name": "Amyloid beta A4 precursor protein-binding family B member 1-interacting protein", "gene_name": "APBB1IP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15056-1", "protein_name": "Serine/threonine-protein kinase B-raf", "gene_name": "BRAF", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04049-1", "protein_name": "RAF proto-oncogene serine/threonine-protein kinase", "gene_name": "RAF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P31946-1", "protein_name": "14-3-3 protein beta/alpha", "gene_name": "YWHAB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P10398-1", "protein_name": "Serine/threonine-protein kinase A-Raf", "gene_name": "ARAF", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27448-5", "protein_name": "MAP/microtubule affinity-regulating kinase 3", "gene_name": "MARK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P60709-1", "protein_name": "Actin, cytoplasmic 1", "gene_name": "ACTB", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9UHA4", "url": "https://www.uniprot.org/uniprotkb/Q9UHA4" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.20858867", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 39 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": 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"glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Raf family kinases: old dogs have learned new tricks.", "journal": "Genes & cancer", "date": "2011", "authors": "Matallanas D, Birtwistle M, Romano D, Zebisch A, Rauch J, von Kriegsheim A, Kolch W", "reference": { "type": "PubMed", "id": "21779496", "url": "https://pubmed.ncbi.nlm.nih.gov/21779496" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9UHA4-1", "protein_name": "Ragulator complex protein LAMTOR3", "gene_name": "LAMTOR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y490-1", "protein_name": 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"protein_name": "Progestin and adipoQ receptor family member 3", "gene_name": "PAQR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62834-1", "protein_name": "Ras-related protein Rap-1A", "gene_name": "RAP1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62714-1", "protein_name": "Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform", "gene_name": "PPP2CB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6W6-1", "protein_name": "Dual specificity protein phosphatase 10", "gene_name": "DUSP10", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16829-1", "protein_name": "Dual specificity protein phosphatase 7", "gene_name": "DUSP7", "tax_name": "Human" }, { "uniprot_canonical_ac": "P28562-1", "protein_name": "Dual specificity protein phosphatase 1", "gene_name": "DUSP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36873-1", "protein_name": "Serine/threonine-protein phosphatase PP1-gamma catalytic subunit", "gene_name": "PPP1CC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04275-1", "protein_name": "von Willebrand factor", "gene_name": "VWF", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18206-1", "protein_name": "Vinculin", "gene_name": "VCL", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0DP23-1", "protein_name": "Calmodulin-1", "gene_name": "CALM1; CALM2; CALM3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35232-1", "protein_name": "Prohibitin 1", "gene_name": "PHB1; PHB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30086-1", "protein_name": "Phosphatidylethanolamine-binding protein 1", "gene_name": "PEBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P53778-1", "protein_name": "Mitogen-activated protein kinase 12", "gene_name": "MAPK12", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BRX9-1", "protein_name": "WD repeat domain-containing protein 83", "gene_name": "WDR83", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UQ13-1", "protein_name": "Leucine-rich repeat protein SHOC-2", "gene_name": "SHOC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P41240-1", "protein_name": "Tyrosine-protein kinase CSK", "gene_name": "CSK", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08514-1", "protein_name": "Integrin alpha-IIb", "gene_name": "ITGA2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q05923-1", "protein_name": "Dual specificity protein phosphatase 2", "gene_name": "DUSP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16690-1", "protein_name": "Dual specificity protein phosphatase 5", "gene_name": "DUSP5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13905-1", "protein_name": "Rap guanine nucleotide exchange factor 1", "gene_name": "RAPGEF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46109-1", "protein_name": "Crk-like protein", "gene_name": "CRKL", "tax_name": "Human" }, { "uniprot_canonical_ac": "P32121-1", "protein_name": "Beta-arrestin-2", "gene_name": "ARRB2", "tax_name": "Human" }, { "uniprot_canonical_ac": 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"tax_name": "Human" }, { "uniprot_canonical_ac": "Q969H4-1", "protein_name": "Connector enhancer of kinase suppressor of ras 1", "gene_name": "CNKSR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WXI2-1", "protein_name": "Connector enhancer of kinase suppressor of ras 2", "gene_name": "CNKSR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02675-1", "protein_name": "Fibrinogen beta chain", "gene_name": "FGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05106-1", "protein_name": "Integrin beta-3", "gene_name": "ITGB3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13557-1", "protein_name": "Calcium/calmodulin-dependent protein kinase type II subunit delta", "gene_name": "CAMK2D", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q02750-1", "protein_name": "Dual specificity mitogen-activated protein kinase kinase 1", "gene_name": "MAP2K1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion 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[] } ] }, { "title": "Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors.", "journal": "Cancer discovery", "date": "2013", "authors": "Morris EJ, Jha S, Restaino CR, Dayananth P, Zhu H, Cooper A, Carr D, Deng Y, Jin W, Black S, Long B, Liu J, Dinunzio E, Windsor W, Zhang R, Zhao S, Angagaw MH, Pinheiro EM, Desai J, Xiao L, Shipps G, Hruza A, Wang J, Kelly J, Paliwal S, Gao X, Babu BS, Zhu L, Daublain P, Zhang L, Lutterbach BA, Pelletier MR, Philippar U, Siliphaivanh P, Witter D, Kirschmeier P, Bishop WR, Hicklin D, Gilliland DG, Jayaraman L, Zawel L, Fawell S, Samatar AA", "reference": { "type": "PubMed", "id": "23614898", "url": "https://pubmed.ncbi.nlm.nih.gov/23614898" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9UHA4-1", "protein_name": "Ragulator complex protein LAMTOR3", "gene_name": "LAMTOR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y490-1", "protein_name": "Talin-1", 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"glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers.", "journal": "Nature", "date": "2013", "authors": "Hatzivassiliou G, Haling JR, Chen H, Song K, Price S, Heald R, Hewitt JF, Zak M, Peck A, Orr C, Merchant M, Hoeflich KP, Chan J, Luoh SM, Anderson DJ, Ludlam MJ, Wiesmann C, Ultsch M, Friedman LS, Malek S, Belvin M", "reference": { "type": "PubMed", "id": "23934108", "url": "https://pubmed.ncbi.nlm.nih.gov/23934108" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9UHA4-1", "protein_name": "Ragulator complex protein LAMTOR3", "gene_name": "LAMTOR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y490-1", "protein_name": "Talin-1", "gene_name": "TLN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02671-1", "protein_name": "Fibrinogen alpha chain", "gene_name": "FGA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46940-1", "protein_name": "Ras GTPase-activating-like protein IQGAP1", "gene_name": "IQGAP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P28482-1", "protein_name": "Mitogen-activated protein 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"glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Targeting RAS-ERK signalling in cancer: promises and challenges.", "journal": "Nature reviews. Drug discovery", "date": "2014", "authors": "Samatar AA, Poulikakos PI", "reference": { "type": "PubMed", "id": "25435214", "url": "https://pubmed.ncbi.nlm.nih.gov/25435214" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9UHA4-1", "protein_name": "Ragulator complex protein LAMTOR3", "gene_name": "LAMTOR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y490-1", "protein_name": "Talin-1", "gene_name": "TLN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02671-1", "protein_name": "Fibrinogen alpha chain", "gene_name": "FGA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46940-1", "protein_name": "Ras GTPase-activating-like protein IQGAP1", "gene_name": "IQGAP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13554-1", "protein_name": "Calcium/calmodulin-dependent protein kinase type II subunit beta", "gene_name": "CAMK2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P28482-1", "protein_name": "Mitogen-activated protein kinase 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"tax_name": "Human" }, { "uniprot_canonical_ac": "Q13555-1", "protein_name": "Calcium/calmodulin-dependent protein kinase type II subunit gamma", "gene_name": "CAMK2G", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01116-1", "protein_name": "GTPase KRas", "gene_name": "KRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16584-1", "protein_name": "Mitogen-activated protein kinase kinase kinase 11", "gene_name": "MAP3K11", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6VAB6-1", "protein_name": "Kinase suppressor of Ras 2", "gene_name": "KSR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27361-1", "protein_name": "Mitogen-activated protein kinase 3", "gene_name": "MAPK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12931-1", "protein_name": "Proto-oncogene tyrosine-protein kinase Src", "gene_name": "SRC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7Z5R6-1", "protein_name": "Amyloid beta A4 precursor protein-binding family B member 1-interacting 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"url": "https://www.uniprot.org/uniprotkb/Q9UHA4" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.25435214", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 49 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-y l)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development.", "journal": "Journal of medicinal chemistry", "date": "2016", "authors": "Blake JF, Burkard M, Chan J, Chen H, Chou KJ, Diaz D, Dudley DA, Gaudino JJ, Gould SE, Grina J, Hunsaker T, Liu L, Martinson M, Moreno D, Mueller L, Orr C, Pacheco P, Qin A, Rasor K, Ren L, Robarge K, Shahidi-Latham S, Stults J, Sullivan F, Wang W, Yin J, Zhou A, Belvin M, Merchant M, Moffat J, Schwarz JB", "reference": { "type": "PubMed", "id": "27227380", "url": "https://pubmed.ncbi.nlm.nih.gov/27227380" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9UHA4-1", "protein_name": "Ragulator complex protein LAMTOR3", "gene_name": "LAMTOR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y490-1", "protein_name": "Talin-1", "gene_name": "TLN1", 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Cell", "date": "2022", "authors": "Egri Shawn B, Ouch Christna, Chou Hui-Ting, Yu Zhiheng, Song Kangkang, Xu Chen, Shen Kuang", "reference": { "type": "PubMed", "id": "35338845", "url": "https://pubmed.ncbi.nlm.nih.gov/35338845" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9UHA4-1", "protein_name": "Ragulator complex protein LAMTOR3", "gene_name": "LAMTOR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HB90-1", "protein_name": "Ras-related GTP-binding protein C", "gene_name": "RRAGC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q12980-1", "protein_name": "GATOR1 complex protein NPRL3", "gene_name": "NPRL3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WTW4-1", "protein_name": "GATOR1 complex protein NPRL2", "gene_name": "NPRL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6IAA8-1", "protein_name": "Ragulator complex protein LAMTOR1", "gene_name": "LAMTOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q0VGL1-1", 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"title": "Overexpression of mitogen-activated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells. Evidence that MAPKK involvement in cellular proliferation is regulated by phosphorylation of serine residues in its kinase subdomains VII and VIII.", "journal": "The Journal of biological chemistry", "date": "1994", "authors": "Seger R, Seger D, Reszka AA, Munar ES, Eldar-Finkelman H, Dobrowolska G, Jensen AM, Campbell JS, Fischer EH, Krebs EG", "reference": { "type": "PubMed", "id": "7929275", "url": "https://pubmed.ncbi.nlm.nih.gov/7929275" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9UHA4-1", "protein_name": "Ragulator complex protein LAMTOR3", "gene_name": "LAMTOR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y490-1", "protein_name": "Talin-1", "gene_name": "TLN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02671-1", "protein_name": "Fibrinogen alpha chain", "gene_name": "FGA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46940-1", "protein_name": "Ras GTPase-activating-like protein IQGAP1", "gene_name": "IQGAP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P28482-1", "protein_name": "Mitogen-activated protein kinase 1", "gene_name": "MAPK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02751-15", "protein_name": "Fibronectin", "gene_name": "FN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36507-1", "protein_name": "Dual specificity mitogen-activated protein kinase kinase 2", "gene_name": "MAP2K2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02679-1", "protein_name": "Fibrinogen gamma chain", "gene_name": "FGG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61224-1", "protein_name": "Ras-related protein Rap-1b", "gene_name": "RAP1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01111-1", "protein_name": "GTPase NRas", "gene_name": "NRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62834-1", "protein_name": "Ras-related protein Rap-1A", "gene_name": "RAP1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04275-1", "protein_name": "von Willebrand factor", "gene_name": "VWF", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18206-1", "protein_name": "Vinculin", "gene_name": "VCL", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30086-1", "protein_name": "Phosphatidylethanolamine-binding protein 1", "gene_name": "PEBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BRX9-1", "protein_name": "WD repeat domain-containing protein 83", "gene_name": "WDR83", "tax_name": "Human" }, { "uniprot_canonical_ac": "P41240-1", "protein_name": "Tyrosine-protein kinase CSK", "gene_name": "CSK", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08514-1", "protein_name": "Integrin alpha-IIb", "gene_name": "ITGA2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P32121-1", "protein_name": "Beta-arrestin-2", "gene_name": "ARRB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63261-1", "protein_name": "Actin, cytoplasmic 2", "gene_name": "ACTG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49407-1", "protein_name": "Beta-arrestin-1", "gene_name": "ARRB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q969H4-1", "protein_name": "Connector enhancer of kinase suppressor of ras 1", "gene_name": "CNKSR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WXI2-1", "protein_name": "Connector enhancer of kinase suppressor of ras 2", "gene_name": "CNKSR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02675-1", "protein_name": "Fibrinogen beta chain", "gene_name": "FGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05106-1", "protein_name": "Integrin beta-3", "gene_name": "ITGB3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q02750-1", "protein_name": "Dual specificity mitogen-activated protein kinase kinase 1", "gene_name": "MAP2K1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y2Q5-1", "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "LAMTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IVT5-1", "protein_name": "Kinase suppressor of Ras 1", "gene_name": "KSR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFM7-1", "protein_name": "Interleukin-17 receptor D", "gene_name": "IL17RD", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6VAB6-1", "protein_name": "Kinase suppressor of Ras 2", "gene_name": "KSR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27361-1", "protein_name": "Mitogen-activated protein kinase 3", "gene_name": "MAPK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12931-1", "protein_name": "Proto-oncogene tyrosine-protein kinase Src", "gene_name": "SRC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7Z5R6-1", "protein_name": "Amyloid beta A4 precursor protein-binding family B member 1-interacting protein", "gene_name": "APBB1IP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15056-1", "protein_name": "Serine/threonine-protein kinase B-raf", "gene_name": "BRAF", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04049-1", "protein_name": "RAF proto-oncogene serine/threonine-protein kinase", "gene_name": "RAF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P31946-1", "protein_name": "14-3-3 protein beta/alpha", "gene_name": "YWHAB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P10398-1", "protein_name": "Serine/threonine-protein kinase A-Raf", "gene_name": "ARAF", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27448-5", "protein_name": "MAP/microtubule affinity-regulating kinase 3", "gene_name": "MARK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P60709-1", "protein_name": "Actin, cytoplasmic 1", "gene_name": "ACTB", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9UHA4", "url": "https://www.uniprot.org/uniprotkb/Q9UHA4" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.7929275", 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"uniprot_canonical_ac": "Q8WXI2-1", "protein_name": "Connector enhancer of kinase suppressor of ras 2", "gene_name": "CNKSR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02675-1", "protein_name": "Fibrinogen beta chain", "gene_name": "FGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05106-1", "protein_name": "Integrin beta-3", "gene_name": "ITGB3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q02750-1", "protein_name": "Dual specificity mitogen-activated protein kinase kinase 1", "gene_name": "MAP2K1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y2Q5-1", "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "LAMTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IVT5-1", "protein_name": "Kinase suppressor of Ras 1", "gene_name": "KSR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFM7-1", "protein_name": "Interleukin-17 receptor D", "gene_name": "IL17RD", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6VAB6-1", "protein_name": 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"protein_name": "Integrin alpha-IIb", "gene_name": "ITGA2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P32121-1", "protein_name": "Beta-arrestin-2", "gene_name": "ARRB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63261-1", "protein_name": "Actin, cytoplasmic 2", "gene_name": "ACTG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49407-1", "protein_name": "Beta-arrestin-1", "gene_name": "ARRB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q969H4-1", "protein_name": "Connector enhancer of kinase suppressor of ras 1", "gene_name": "CNKSR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WXI2-1", "protein_name": "Connector enhancer of kinase suppressor of ras 2", "gene_name": "CNKSR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02675-1", "protein_name": "Fibrinogen beta chain", "gene_name": "FGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05106-1", "protein_name": "Integrin beta-3", "gene_name": "ITGB3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q02750-1", "protein_name": "Dual specificity mitogen-activated protein kinase kinase 1", "gene_name": "MAP2K1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y2Q5-1", "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "LAMTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IVT5-1", "protein_name": "Kinase suppressor of Ras 1", "gene_name": "KSR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFM7-1", "protein_name": "Interleukin-17 receptor D", "gene_name": "IL17RD", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6VAB6-1", "protein_name": "Kinase suppressor of Ras 2", "gene_name": "KSR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27361-1", "protein_name": "Mitogen-activated protein kinase 3", "gene_name": "MAPK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12931-1", "protein_name": "Proto-oncogene tyrosine-protein kinase Src", "gene_name": "SRC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7Z5R6-1", 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Immunol.", "date": "1989", "authors": "Go\u00f1i F R, Chen P P, McGinnis D, Arjonilla M L, Fernandez J, Carson D, Solomon A, Mendez E, Frangione B", "reference": { "type": "PubMed", "id": "2496160", "url": "https://pubmed.ncbi.nlm.nih.gov/2496160" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P01593-1", "protein_name": "Immunoglobulin kappa variable 1D-33", "gene_name": "IGKV1D-33", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P01593", "url": "https://www.uniprot.org/uniprotkb/P01593" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.2496160", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The primary structure of a human immunoglobulin L-chain of kappa-type (Bence-Jones protein Scw.), II: the chymotryptic peptides and the complete amino acid sequence.", "journal": "Hoppe-Seyler's Z. Physiol. Chem.", "date": "1974", "authors": "Eulitz M, Hilschmann N", "reference": { "type": "PubMed", "id": "4435756", "url": "https://pubmed.ncbi.nlm.nih.gov/4435756" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P01593-1", "protein_name": "Immunoglobulin kappa variable 1D-33", "gene_name": "IGKV1D-33", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P01593", "url": "https://www.uniprot.org/uniprotkb/P01593" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.4435756", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Principle of antibody structure. The primary structure of a monoclonal kappa I-type immunoglobulin L-chain (Bence Jones protein Bi). 3. The complete amino acid sequence and the genetic significance of the variability principles for the mechanism of antibody formation.", "journal": "Hoppe-Seyler's Z. Physiol. Chem.", "date": "1972", "authors": "Braun M, Leibold W, Barnikol H U, Hilschmann N", "reference": { "type": "PubMed", "id": "4563064", "url": "https://pubmed.ncbi.nlm.nih.gov/4563064" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P01593-1", "protein_name": "Immunoglobulin kappa variable 1D-33", "gene_name": "IGKV1D-33", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P01593", "url": "https://www.uniprot.org/uniprotkb/P01593" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.4563064", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Amino acid sequence of a human kappa type Bence-Jones protein. 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Mol. Biol.", "date": "1981", "authors": "Stevens F J, Westholm F A, Panagiotopoulos N, Schiffer M, Popp R A, Solomon A", "reference": { "type": "PubMed", "id": "6167731", "url": "https://pubmed.ncbi.nlm.nih.gov/6167731" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P01593-1", "protein_name": "Immunoglobulin kappa variable 1D-33", "gene_name": "IGKV1D-33", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P01593", "url": "https://www.uniprot.org/uniprotkb/P01593" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.6167731", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", 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U.S.A.", "date": "1983", "authors": "Goni F, Frangione B", "reference": { "type": "PubMed", "id": "6410398", "url": "https://pubmed.ncbi.nlm.nih.gov/6410398" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P01599-1", "protein_name": "Immunoglobulin kappa variable 1-17", "gene_name": "IGKV1-17", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01763-1", "protein_name": "Immunoglobulin heavy variable 3-48", "gene_name": "IGHV3-48", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P01599", "url": "https://www.uniprot.org/uniprotkb/P01599" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.6410398", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } 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factor receptor 1", "gene_name": "FLT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VWN6-1", "protein_name": "Protein TASOR 2", "gene_name": "TASOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VZK9-1", "protein_name": "F-actin-uncapping protein LRRC16A", "gene_name": "CARMIL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27361-1", "protein_name": "Mitogen-activated protein kinase 3", "gene_name": "MAPK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P51795-2", "protein_name": "H(+)/Cl(-) exchange transporter 5", "gene_name": "CLCN5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14204-1", "protein_name": "Cytoplasmic dynein 1 heavy chain 1", "gene_name": "DYNC1H1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NVP1-1", "protein_name": "ATP-dependent RNA helicase DDX18", "gene_name": "DDX18", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62495-1", "protein_name": "Eukaryotic peptide chain release factor subunit 1", "gene_name": "ETF1", 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Immunol.", "date": "1986", "authors": "Newkirk M, Chen P P, Carson D, Posnett D, Capra J D", "reference": { "type": "PubMed", "id": "3086710", "url": "https://pubmed.ncbi.nlm.nih.gov/3086710" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P01619-1", "protein_name": "Immunoglobulin kappa variable 3-20", "gene_name": "IGKV3-20", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P01619", "url": "https://www.uniprot.org/uniprotkb/P01619" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.3086710", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunotherapy.", "journal": "J. Exp. Med.", "date": "1988", "authors": "Kipps T J, Tomhave E, Chen P P, Carson D A", "reference": { "type": "PubMed", "id": "3127527", "url": "https://pubmed.ncbi.nlm.nih.gov/3127527" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P01619-1", "protein_name": "Immunoglobulin kappa variable 3-20", "gene_name": "IGKV3-20", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P01619", "url": "https://www.uniprot.org/uniprotkb/P01619" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.3127527", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": 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Chem.", "date": "1972", "authors": "Suter L, Barnikol H U, Watanabe S, Hilschmann N", "reference": { "type": "PubMed", "id": "5027703", "url": "https://pubmed.ncbi.nlm.nih.gov/5027703" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P01619-1", "protein_name": "Immunoglobulin kappa variable 3-20", "gene_name": "IGKV3-20", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01834-1", "protein_name": "Immunoglobulin kappa constant", "gene_name": "IGKC", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P01619", "url": "https://www.uniprot.org/uniprotkb/P01619" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.5027703", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": 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"glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Identification of a novel human adenylate kinase. cDNA cloning, expression analysis, chromosome localization and characterization of the recombinant protein.", "journal": "European journal of biochemistry", "date": "1999", "authors": "Van Rompay AR, Johansson M, Karlsson A", "reference": { "type": "PubMed", "id": "10215863", "url": "https://pubmed.ncbi.nlm.nih.gov/10215863" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P23919-1", "protein_name": "Thymidylate kinase", "gene_name": "DTYMK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MA6-1", "protein_name": "Adenylate kinase 8", "gene_name": "AK8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P31350-1", "protein_name": "Ribonucleoside-diphosphate reductase subunit M2", "gene_name": "RRM2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H773-1", "protein_name": "dCTP pyrophosphatase 1", "gene_name": "DCTPP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16881-1", "protein_name": "Thioredoxin reductase 1, cytoplasmic", "gene_name": "TXNRD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86X67-1", "protein_name": "NAD(P)H pyrophosphatase NUDT13, mitochondrial", "gene_name": "NUDT13", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75414-1", "protein_name": "Nucleoside diphosphate kinase 6, mitochondrial", "gene_name": "NME6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NRF8-1", "protein_name": "CTP synthase 2", "gene_name": "CTPS2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P23921-1", "protein_name": "Ribonucleoside-diphosphate reductase large subunit", "gene_name": "RRM1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7LG56-1", "protein_name": "Ribonucleoside-diphosphate reductase subunit M2 B", "gene_name": "RRM2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P10599-1", "protein_name": "Thioredoxin", "gene_name": "TXN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5TCS8-4", "protein_name": "Adenylate kinase 9", "gene_name": "AK9", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15531-1", "protein_name": "Nucleoside diphosphate kinase A", "gene_name": "NME1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P54819-1", "protein_name": "Adenylate kinase 2, mitochondrial", "gene_name": "AK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00568-1", "protein_name": "Adenylate kinase isoenzyme 1", "gene_name": "AK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16774-1", "protein_name": "Guanylate kinase", "gene_name": "GUK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96M32-1", "protein_name": "Adenylate kinase 7", "gene_name": "AK7", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27144-1", "protein_name": "Adenylate kinase 4, mitochondrial", "gene_name": "AK4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6K8-1", "protein_name": "Adenylate kinase isoenzyme 5", "gene_name": "AK5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22392-1", "protein_name": "Nucleoside diphosphate kinase B", "gene_name": "NME1-NME2; NME2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y3D8-1", "protein_name": "Adenylate kinase isoenzyme 6", "gene_name": "AK6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13232-1", "protein_name": "Nucleoside diphosphate kinase C", "gene_name": "NME3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30085-1", "protein_name": "UMP-CMP kinase", "gene_name": "CMPK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P17812-1", "protein_name": "CTP synthase 1", "gene_name": "CTPS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00746-1", "protein_name": "Nucleoside diphosphate kinase D, mitochondrial", "gene_name": "NME4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P32321-1", "protein_name": "Deoxycytidylate deaminase", "gene_name": "DCTD", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35754-1", "protein_name": "Glutaredoxin-1", "gene_name": "GLRX", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04818-1", "protein_name": "Thymidylate synthase", "gene_name": "TYMS", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P23919", "url": "https://www.uniprot.org/uniprotkb/P23919" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10215863", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 28 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "NME6: a new member of the nm23/nucleoside diphosphate kinase gene family located on human chromosome 3p21.3.", "journal": "Human genetics", "date": "1999", "authors": "Mehus JG, Deloukas P, Lambeth DO", "reference": { "type": "PubMed", "id": "10453732", "url": "https://pubmed.ncbi.nlm.nih.gov/10453732" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P23919-1", "protein_name": "Thymidylate kinase", "gene_name": "DTYMK", "tax_name": "Human" }, { "uniprot_canonical_ac": "O88425-1", "protein_name": "Nucleoside diphosphate kinase 6, mitochondrial", "gene_name": "Nme6", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q96MA6-1", "protein_name": "Adenylate kinase 8", "gene_name": "AK8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P31350-1", "protein_name": "Ribonucleoside-diphosphate reductase subunit M2", "gene_name": "RRM2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H773-1", "protein_name": "dCTP pyrophosphatase 1", "gene_name": "DCTPP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16881-1", "protein_name": "Thioredoxin reductase 1, cytoplasmic", "gene_name": "TXNRD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86X67-1", "protein_name": "NAD(P)H pyrophosphatase NUDT13, mitochondrial", "gene_name": "NUDT13", "tax_name": "Human" }, { "uniprot_canonical_ac": "O88426-1", "protein_name": "Nucleoside diphosphate kinase 6, mitochondrial", "gene_name": "Nme6", "tax_name": "Rat" }, { "uniprot_canonical_ac": "O75414-1", "protein_name": "Nucleoside diphosphate kinase 6, mitochondrial", "gene_name": "NME6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NRF8-1", "protein_name": "CTP synthase 2", "gene_name": "CTPS2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P23921-1", "protein_name": "Ribonucleoside-diphosphate reductase large subunit", "gene_name": "RRM1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7LG56-1", "protein_name": "Ribonucleoside-diphosphate reductase subunit M2 B", "gene_name": "RRM2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P10599-1", "protein_name": "Thioredoxin", "gene_name": "TXN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5TCS8-4", "protein_name": "Adenylate kinase 9", "gene_name": "AK9", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15531-1", "protein_name": "Nucleoside diphosphate kinase A", "gene_name": "NME1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P54819-1", "protein_name": "Adenylate kinase 2, mitochondrial", "gene_name": "AK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00568-1", "protein_name": "Adenylate kinase isoenzyme 1", "gene_name": "AK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16774-1", "protein_name": "Guanylate kinase", "gene_name": "GUK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96M32-1", "protein_name": "Adenylate kinase 7", "gene_name": "AK7", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27144-1", "protein_name": "Adenylate kinase 4, mitochondrial", "gene_name": "AK4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6K8-1", "protein_name": "Adenylate kinase isoenzyme 5", "gene_name": "AK5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22392-1", "protein_name": "Nucleoside diphosphate kinase B", "gene_name": "NME1-NME2; NME2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y3D8-1", "protein_name": "Adenylate kinase isoenzyme 6", "gene_name": "AK6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13232-1", "protein_name": "Nucleoside diphosphate kinase C", "gene_name": "NME3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30085-1", "protein_name": "UMP-CMP kinase", "gene_name": "CMPK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P17812-1", "protein_name": "CTP synthase 1", "gene_name": "CTPS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00746-1", "protein_name": "Nucleoside diphosphate kinase D, mitochondrial", "gene_name": "NME4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P32321-1", "protein_name": "Deoxycytidylate deaminase", "gene_name": "DCTD", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35754-1", "protein_name": "Glutaredoxin-1", "gene_name": "GLRX", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04818-1", "protein_name": "Thymidylate synthase", "gene_name": "TYMS", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P23919", "url": "https://www.uniprot.org/uniprotkb/P23919" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10453732", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 30 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 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