[ { "title": "The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha.", "journal": "Mol. Cell. Biol.", "date": "2005", "authors": "Kisseleva M, Feng Y, Ward M, Song C, Anderson RA, Longmore GD", "reference": { "type": "PubMed", "id": "15870270", "url": "https://pubmed.ncbi.nlm.nih.gov/15870270" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q91XC0-1", "protein_name": "LIM domain-containing protein ajuba", "gene_name": "Ajuba", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q99755-1", "protein_name": "Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha", "gene_name": "PIP5K1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P70181-1", "protein_name": "Phosphatidylinositol 4-phosphate 5-kinase type-1 beta", "gene_name": "Pip5k1b", "tax_name": "Mouse" } ], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q91XC0", "url": "https://www.uniprot.org/uniprotkb/Q91XC0" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "record_id": 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WJ, Goyal RK, Langer EM, Longmore GD, Rauscher FJ 3rd", "reference": { "type": "PubMed", "id": "17909014", "url": "https://pubmed.ncbi.nlm.nih.gov/17909014" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q91XC0-1", "protein_name": "LIM domain-containing protein ajuba", "gene_name": "Ajuba", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q7TQJ8-1", "protein_name": "Wilms tumor protein 1-interacting protein", "gene_name": "Wtip", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q96IF1-1", "protein_name": "LIM domain-containing protein ajuba", "gene_name": "AJUBA", "tax_name": "Human" } ], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q91XC0", "url": "https://www.uniprot.org/uniprotkb/Q91XC0" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "record_id": "pubmed.17909014", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], 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Commun.", "date": "2004", "authors": "Shimamura Mitsuru, Matsuda Morihiro, Ando Yosuke, Koishi Ryuta, Yasumo Hiroaki, Furukawa Hidehiko, Shimomura Iichiro", "reference": { "type": "PubMed", "id": "15336575", "url": "https://pubmed.ncbi.nlm.nih.gov/15336575" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9R182-1", "protein_name": "Angiopoietin-related protein 3", "gene_name": "Angptl3", "tax_name": "Mouse" } ], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q9R182", "url": "https://www.uniprot.org/uniprotkb/Q9R182" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "record_id": "pubmed.15336575", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Differential regulation and properties of angiopoietin-like proteins 3 and 4.", "journal": "J. 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Pathol.", "date": "2015", "authors": "Hodgkinson Victoria L, Dale Jeffery M, Garcia Michael L, Weisman Gary A, Lee Jaekwon, Gitlin Jonathan D, Petris Michael J", "reference": { "type": "PubMed", "id": "25639447", "url": "https://pubmed.ncbi.nlm.nih.gov/25639447" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q64430-1", "protein_name": "Copper-transporting ATPase 1", "gene_name": "Atp7a", "tax_name": "Mouse" } ], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q64430", "url": "https://www.uniprot.org/uniprotkb/Q64430" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "record_id": "pubmed.25639447", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ 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"Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons.", "journal": "Cell", "date": "1993-11-05", "authors": "Guillemot F, Lo L C, Johnson J E, Auerbach A, Anderson D J, Joyner A L", "reference": { "type": "PubMed", "id": "8221886", "url": "https://pubmed.ncbi.nlm.nih.gov/8221886" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q02067-1", "protein_name": "Achaete-scute homolog 1", "gene_name": "Ascl1", "tax_name": "Mouse" } ], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q02067", "url": "https://www.uniprot.org/uniprotkb/Q02067" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "record_id": "pubmed.8221886", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { 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Patterns", "date": "2009", "authors": "Yu Vionnie W C, Akhouayri Omar, St-Arnaud Ren\u00e9", "reference": { "type": "PubMed", "id": "19232401", "url": "https://pubmed.ncbi.nlm.nih.gov/19232401" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q06507-1", "protein_name": "Cyclic AMP-dependent transcription factor ATF-4", "gene_name": "Atf4", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q8BHN1-1", "protein_name": "Gamma-taxilin", "gene_name": "Txlng", "tax_name": "Mouse" } ], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q06507", "url": "https://www.uniprot.org/uniprotkb/Q06507" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "record_id": "pubmed.19232401", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { 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Takamitsu, Matsunaga Naoya, Fujimura Akio, Ohdo Shigehiro", "reference": { "type": "PubMed", "id": "22572884", "url": "https://pubmed.ncbi.nlm.nih.gov/22572884" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q06507-1", "protein_name": "Cyclic AMP-dependent transcription factor ATF-4", "gene_name": "Atf4", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q60857-1", "protein_name": "Sodium-dependent serotonin transporter", "gene_name": "Slc6a4", "tax_name": "Mouse" } ], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q06507", "url": "https://www.uniprot.org/uniprotkb/Q06507" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "record_id": "pubmed.22572884", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": 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Pathol.", "date": "2006", "authors": "Rhiemeier V, Breitenbach U, Richter KH, Gebhardt C, Vogt I, Hartenstein B, Furstenberger G, Mauch C, Hess J, Angel P", "reference": { "type": "PubMed", "id": "16565508", "url": "https://pubmed.ncbi.nlm.nih.gov/16565508" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q09PK2-1", "protein_name": "Retroviral-like aspartic protease 1", "gene_name": "Asprv1", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q53RT3-1", "protein_name": "Retroviral-like aspartic protease 1", "gene_name": "ASPRV1", "tax_name": "Human" } ], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q09PK2", "url": "https://www.uniprot.org/uniprotkb/Q09PK2" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "record_id": "pubmed.16565508", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], 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haploinsufficiency on adrenocortical function.", "journal": "Human molecular genetics", "date": "2017", "authors": "Berthon A, Faucz FR, Espiard S, Drougat L, Bertherat J, Stratakis CA", "reference": { "type": "PubMed", "id": "28911199", "url": "https://pubmed.ncbi.nlm.nih.gov/28911199" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q5EBP3-1", "protein_name": "Armadillo repeat-containing protein 5", "gene_name": "Armc5", "tax_name": "Mouse" } ], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q5EBP3", "url": "https://www.uniprot.org/uniprotkb/Q5EBP3" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "record_id": "pubmed.28911199", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death.", "journal": "Cell", "date": "2010", "authors": "Radoshevich L, Murrow L, Chen N, Fernandez E, Roy S, Fung C, Debnath J", "reference": { "type": "PubMed", "id": "20723759", "url": "https://pubmed.ncbi.nlm.nih.gov/20723759" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9CQY1-1", "protein_name": "Ubiquitin-like protein ATG12", "gene_name": "Atg12", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q9D906-1", "protein_name": "Ubiquitin-like modifier-activating enzyme ATG7", "gene_name": "Atg7", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q8R1P4-1", "protein_name": "Ubiquitin-like-conjugating enzyme ATG10", "gene_name": "Atg10", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q9CPX6-1", "protein_name": "Ubiquitin-like-conjugating enzyme ATG3", "gene_name": "Atg3", "tax_name": "Mouse" } ], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q9CQY1", "url": "https://www.uniprot.org/uniprotkb/Q9CQY1" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "mutagenesis": [ { "start_pos": 165, "end_pos": 165, "sequence_org": "C", "sequence_mut": "S", "comment": "Instead of the formation of an intermediate complex with a thiol ester bond between ATG10 (E2-like enzyme) and ATG12 (substrate), a stable complex with an O-ester bond is formed. Does not affect ATG12 conjugation to ATG3.", "evidence": [ { "database": "UniProtKB", "id": "Q8R1P4", "url": "https://www.uniprot.org/uniprotkb/Q8R1P4" }, { "database": "PubMed", "id": "20723759", "url": "https://pubmed.ncbi.nlm.nih.gov/20723759" }, { "database": "PubMed", "id": "12890687", "url": "https://pubmed.ncbi.nlm.nih.gov/12890687" }, { "database": "PubMed", "id": "12482611", "url": "https://pubmed.ncbi.nlm.nih.gov/12482611" } ], "uniprot_canonical_ac": "Q8R1P4-1" }, { "start_pos": 243, "end_pos": 243, "sequence_org": "K", "sequence_mut": "R", "comment": "Abolishes ATG12 conjugation, leading to an expansion in mitochondrial mass and fragmented mitochondrial morphology. Does not affect PE-conjugation to ATG8-like proteins. Reduces autophagosome maturation. Affects multivesicular bodies (MVBs) distribution and morphology. Exhibits defects in late endosome to lysosome trafficking. Does not interacts with PDCD6IP.", "evidence": [ { "database": "UniProtKB", "id": "Q9CPX6", "url": "https://www.uniprot.org/uniprotkb/Q9CPX6" }, { "database": "PubMed", "id": "25686249", "url": "https://pubmed.ncbi.nlm.nih.gov/25686249" }, { "database": "PubMed", "id": "20723759", "url": "https://pubmed.ncbi.nlm.nih.gov/20723759" } ], "uniprot_canonical_ac": "Q9CPX6-1" }, { "start_pos": 264, "end_pos": 264, "sequence_org": "C", "sequence_mut": "A", "comment": "Abolishes E2-like activity.", "evidence": [ { "database": "UniProtKB", "id": "Q9CPX6", "url": "https://www.uniprot.org/uniprotkb/Q9CPX6" }, { "database": "PubMed", "id": "20723759", "url": "https://pubmed.ncbi.nlm.nih.gov/20723759" } ], "uniprot_canonical_ac": "Q9CPX6-1" }, { "start_pos": 271, "end_pos": 271, "sequence_org": "K", "sequence_mut": "R", "comment": "Does not affect ATG12 conjugation.", "evidence": [ { "database": "UniProtKB", "id": "Q9CPX6", "url": "https://www.uniprot.org/uniprotkb/Q9CPX6" }, { "database": "PubMed", "id": "20723759", "url": "https://pubmed.ncbi.nlm.nih.gov/20723759" } ], "uniprot_canonical_ac": "Q9CPX6-1" }, { "start_pos": 295, "end_pos": 295, "sequence_org": "K", "sequence_mut": "R", "comment": "Does not affect ATG12 conjugation.", "evidence": [ { "database": "UniProtKB", "id": "Q9CPX6", "url": "https://www.uniprot.org/uniprotkb/Q9CPX6" }, { "database": "PubMed", "id": "20723759", "url": "https://pubmed.ncbi.nlm.nih.gov/20723759" } ], "uniprot_canonical_ac": "Q9CPX6-1" }, { "start_pos": 71, "end_pos": 71, "sequence_org": "K", "sequence_mut": "R", "comment": "Does not affect ATG12 conjugation.", "evidence": [ { "database": "UniProtKB", "id": "Q9CPX6", "url": "https://www.uniprot.org/uniprotkb/Q9CPX6" }, { "database": "PubMed", "id": "20723759", "url": "https://pubmed.ncbi.nlm.nih.gov/20723759" } ], "uniprot_canonical_ac": "Q9CPX6-1" }, { "start_pos": 83, "end_pos": 83, "sequence_org": "K", "sequence_mut": "R", "comment": "Does not affect ATG12 conjugation.", "evidence": [ { "database": "UniProtKB", "id": "Q9CPX6", "url": "https://www.uniprot.org/uniprotkb/Q9CPX6" }, { "database": "PubMed", "id": "20723759", "url": "https://pubmed.ncbi.nlm.nih.gov/20723759" } ], "uniprot_canonical_ac": "Q9CPX6-1" } ], "record_id": "pubmed.20723759", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] } ]