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9606, "evidence": [ { "database": "UniProtKB", "id": "P78369", "url": "https://www.uniprot.org/uniprotkb/P78369" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.19383724", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", 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"Multiplex epithelium dysfunction due to CLDN10 mutation: the HELIX syndrome.", "journal": "Genetics in medicine : official journal of the American College of Medical Genetics", "date": "2018", "authors": "Hadj-Rabia S, Brideau G, Al-Sarraj Y, Maroun RC, Figueres ML, Leclerc-Mercier S, Olinger E, Baron S, Chaussain C, Nochy D, Taha RZ, Knebelmann B, Joshi V, Curmi PA, Kambouris M, Vargas-Poussou R, Bodemer C, Devuyst O, Houillier P, El-Shanti H", "reference": { "type": "PubMed", "id": "28771254", "url": "https://pubmed.ncbi.nlm.nih.gov/28771254" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P78369-1", "protein_name": "Claudin-10", "gene_name": "CLDN10", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Z0S6-1", "protein_name": "Claudin-10", "gene_name": "Cldn10", "tax_name": "Mouse" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P78369", "url": "https://www.uniprot.org/uniprotkb/P78369" } 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Biol.", "date": "1986", "authors": "Darling S M, Goodfellow P J, Pym B, Banting G S, Pritchard C, Goodfellow P N", "reference": { "type": "PubMed", "id": "3472717", "url": "https://pubmed.ncbi.nlm.nih.gov/3472717" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P14209-1", "protein_name": "CD99 antigen", "gene_name": "CD99", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P14209", "url": "https://www.uniprot.org/uniprotkb/P14209" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.3472717", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": 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"count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway.", "journal": "Molecular and cellular biology", "date": "1999", "authors": "You M, Yu DH, Feng GS", "reference": { "type": "PubMed", "id": "10022928", "url": "https://pubmed.ncbi.nlm.nih.gov/10022928" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15524-1", "protein_name": "Suppressor of cytokine signaling 1", "gene_name": "SOCS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01563-1", "protein_name": "Interferon alpha-2", "gene_name": "IFNA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01567-1", "protein_name": "Interferon alpha-7", "gene_name": "IFNA7", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01568-1", "protein_name": "Interferon alpha-21", "gene_name": "IFNA21", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01569-1", "protein_name": "Interferon alpha-5", "gene_name": "IFNA5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01570-1", "protein_name": "Interferon alpha-14", "gene_name": "IFNA14", "tax_name": "Human" }, { "uniprot_canonical_ac": "P32881-1", "protein_name": "Interferon alpha-8", "gene_name": "IFNA8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05013-1", "protein_name": "Interferon alpha-6", "gene_name": "IFNA6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18031-1", "protein_name": "Tyrosine-protein phosphatase non-receptor type 1", "gene_name": "PTPN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P29350-1", "protein_name": "Tyrosine-protein phosphatase non-receptor type 6", "gene_name": "PTPN6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P52630-3", "protein_name": "Signal transducer and activator of transcription 2", "gene_name": "STAT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UMW8-1", "protein_name": "Ubl carboxyl-terminal hydrolase 18", "gene_name": "USP18", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05014-1", "protein_name": "Interferon alpha-4", "gene_name": "IFNA4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06124-2", "protein_name": "Tyrosine-protein phosphatase non-receptor type 11", "gene_name": "PTPN11", "tax_name": "Human" }, { "uniprot_canonical_ac": "P29597-1", "protein_name": "Non-receptor tyrosine-protein kinase TYK2", "gene_name": "TYK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14543-1", "protein_name": "Suppressor of cytokine signaling 3", "gene_name": "SOCS3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0DY56-1", "protein_name": "Interferon alpha-1", "gene_name": "IFNA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01566-1", "protein_name": "Interferon alpha-10", "gene_name": "IFNA10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01571-1", "protein_name": "Interferon alpha-17", "gene_name": "IFNA17", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01574-1", "protein_name": "Interferon beta", "gene_name": "IFNB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05015-1", "protein_name": "Interferon alpha-16", "gene_name": "IFNA16", "tax_name": "Human" }, { "uniprot_canonical_ac": "P23458-1", "protein_name": "Tyrosine-protein kinase JAK1", "gene_name": "JAK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P17181-1", "protein_name": "Interferon alpha/beta receptor 1", "gene_name": "IFNAR1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15524", "url": "https://www.uniprot.org/uniprotkb/O15524" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10022928", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 23 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop.", "journal": "The EMBO journal", "date": "1999", "authors": "Yasukawa H, Misawa H, Sakamoto H, Masuhara M, Sasaki A, Wakioka T, Ohtsuka S, Imaizumi T, Matsuda T, Ihle JN, Yoshimura A", "reference": { "type": "PubMed", "id": "10064597", "url": "https://pubmed.ncbi.nlm.nih.gov/10064597" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15524-1", "protein_name": "Suppressor of cytokine signaling 1", "gene_name": "SOCS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38484-1", "protein_name": "Interferon gamma receptor 2", "gene_name": "IFNGR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60674-1", "protein_name": "Tyrosine-protein kinase JAK2", "gene_name": "JAK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01579-1", "protein_name": "Interferon gamma", "gene_name": "IFNG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15260-1", "protein_name": "Interferon gamma receptor 1", "gene_name": "IFNGR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O35716-1", "protein_name": "Suppressor of cytokine signaling 1", "gene_name": "Socs1", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "P18031-1", "protein_name": "Tyrosine-protein phosphatase non-receptor type 1", "gene_name": "PTPN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P29350-1", "protein_name": "Tyrosine-protein phosphatase non-receptor type 6", "gene_name": "PTPN6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q62120-1", "protein_name": "Tyrosine-protein kinase JAK2", "gene_name": "Jak2", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "P63165-1", "protein_name": "Small ubiquitin-related modifier 1", "gene_name": "SUMO1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06124-2", "protein_name": "Tyrosine-protein phosphatase non-receptor type 11", "gene_name": "PTPN11", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14543-1", "protein_name": "Suppressor of cytokine signaling 3", "gene_name": "SOCS3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75925-1", "protein_name": "E3 SUMO-protein ligase PIAS1", "gene_name": "PIAS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P23458-1", "protein_name": "Tyrosine-protein kinase JAK1", "gene_name": "JAK1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15524", "url": "https://www.uniprot.org/uniprotkb/O15524" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 105, "end_pos": 105, "sequence_org": "R", "sequence_mut": "K", "comment": "Loss of LIF signal transduction suppression. Loss of binding to KIT. No effect on binding to VAV.", "evidence": [ { "database": "UniProtKB", "id": "O35716", "url": "https://www.uniprot.org/uniprotkb/O35716" }, { "database": "PubMed", "id": "10064597", "url": "https://pubmed.ncbi.nlm.nih.gov/10064597" } ], "uniprot_canonical_ac": "O35716-1" }, { "start_pos": 105, "end_pos": 105, "sequence_org": "R", "sequence_mut": "Q", "comment": "Loss of IL-6 signal transduction suppression. No effect on binding to TYK2.", "evidence": [ { "database": "UniProtKB", "id": "O35716", "url": "https://www.uniprot.org/uniprotkb/O35716" }, { "database": "PubMed", "id": "10064597", "url": "https://pubmed.ncbi.nlm.nih.gov/10064597" } ], "uniprot_canonical_ac": "O35716-1" }, { "start_pos": 55, "end_pos": 55, "sequence_org": "H", "sequence_mut": "A", "comment": "No effect on JAK signal transduction suppression.", "evidence": [ { "database": "UniProtKB", "id": "O35716", "url": "https://www.uniprot.org/uniprotkb/O35716" }, { "database": "PubMed", "id": "10064597", "url": "https://pubmed.ncbi.nlm.nih.gov/10064597" } ], "uniprot_canonical_ac": "O35716-1" }, { "start_pos": 55, "end_pos": 55, "sequence_org": "H", "sequence_mut": "D", "comment": "No effect on JAK signal transduction suppression.", "evidence": [ { "database": "UniProtKB", "id": "O35716", "url": "https://www.uniprot.org/uniprotkb/O35716" }, { "database": "PubMed", "id": "10064597", "url": "https://pubmed.ncbi.nlm.nih.gov/10064597" } ], "uniprot_canonical_ac": "O35716-1" }, { "start_pos": 56, "end_pos": 56, "sequence_org": "F", "sequence_mut": "A", "comment": "Loss of JAK signal transduction suppression.", "evidence": [ { "database": "UniProtKB", "id": "O35716", "url": "https://www.uniprot.org/uniprotkb/O35716" }, { "database": "PubMed", "id": "10064597", "url": "https://pubmed.ncbi.nlm.nih.gov/10064597" } ], "uniprot_canonical_ac": "O35716-1" }, { "start_pos": 56, "end_pos": 56, "sequence_org": "F", "sequence_mut": "D", "comment": "Loss of JAK signal transduction suppression.", "evidence": [ { "database": "UniProtKB", "id": "O35716", "url": "https://www.uniprot.org/uniprotkb/O35716" }, { "database": "PubMed", "id": "10064597", "url": "https://pubmed.ncbi.nlm.nih.gov/10064597" } ], "uniprot_canonical_ac": "O35716-1" }, { "start_pos": 56, "end_pos": 56, "sequence_org": "F", "sequence_mut": "E", "comment": "Reduced binding to JH1.", "evidence": [ { "database": "UniProtKB", "id": "O35716", "url": "https://www.uniprot.org/uniprotkb/O35716" }, { "database": "PubMed", "id": "10064597", "url": "https://pubmed.ncbi.nlm.nih.gov/10064597" } ], "uniprot_canonical_ac": "O35716-1" }, { "start_pos": 56, "end_pos": 56, "sequence_org": "F", "sequence_mut": "L", "comment": "No effect on JAK signal transduction inhibition nor on binding to JH1.", "evidence": [ { "database": "UniProtKB", "id": "O35716", "url": "https://www.uniprot.org/uniprotkb/O35716" }, { "database": "PubMed", "id": "10064597", "url": "https://pubmed.ncbi.nlm.nih.gov/10064597" } ], "uniprot_canonical_ac": "O35716-1" }, { "start_pos": 56, "end_pos": 56, "sequence_org": "F", "sequence_mut": "S", "comment": "Loss of JAK signal transduction suppression.", "evidence": [ { "database": "UniProtKB", "id": "O35716", "url": "https://www.uniprot.org/uniprotkb/O35716" }, { "database": "PubMed", "id": "10064597", "url": "https://pubmed.ncbi.nlm.nih.gov/10064597" } ], "uniprot_canonical_ac": "O35716-1" }, { "start_pos": 56, "end_pos": 56, "sequence_org": "F", "sequence_mut": "S", "comment": "Reduced binding to JH1.", "evidence": [ { "database": "UniProtKB", "id": "O35716", "url": "https://www.uniprot.org/uniprotkb/O35716" }, { "database": "PubMed", "id": "10064597", "url": "https://pubmed.ncbi.nlm.nih.gov/10064597" } ], "uniprot_canonical_ac": "O35716-1" }, { "start_pos": 57, "end_pos": 57, "sequence_org": "R", "sequence_mut": "A", "comment": "No effect on JAK signal transduction suppression.", "evidence": [ { "database": "UniProtKB", "id": "O35716", "url": "https://www.uniprot.org/uniprotkb/O35716" }, { "database": "PubMed", "id": "10064597", "url": "https://pubmed.ncbi.nlm.nih.gov/10064597" } ], "uniprot_canonical_ac": "O35716-1" }, { "start_pos": 57, "end_pos": 57, "sequence_org": "R", "sequence_mut": "E", "comment": "No effect on JAK signal transduction suppression.", "evidence": [ { "database": "UniProtKB", "id": "O35716", "url": "https://www.uniprot.org/uniprotkb/O35716" }, { "database": "PubMed", "id": "10064597", "url": "https://pubmed.ncbi.nlm.nih.gov/10064597" } ], "uniprot_canonical_ac": "O35716-1" }, { "start_pos": 58, "end_pos": 58, "sequence_org": "T", "sequence_mut": "A", "comment": "No effect on JAK signal transduction suppression.", "evidence": [ { "database": "UniProtKB", "id": "O35716", "url": "https://www.uniprot.org/uniprotkb/O35716" }, { "database": "PubMed", "id": "10064597", "url": "https://pubmed.ncbi.nlm.nih.gov/10064597" } ], "uniprot_canonical_ac": "O35716-1" }, { "start_pos": 59, "end_pos": 59, "sequence_org": "F", "sequence_mut": "A", "comment": "Loss of JAK signal transduction suppression. Reduced binding to JH1.", "evidence": [ { "database": "UniProtKB", "id": "O35716", "url": "https://www.uniprot.org/uniprotkb/O35716" }, { "database": "PubMed", "id": "10064597", "url": "https://pubmed.ncbi.nlm.nih.gov/10064597" }, { "database": "PubMed", "id": "11522790", "url": "https://pubmed.ncbi.nlm.nih.gov/11522790" } ], "uniprot_canonical_ac": "O35716-1" }, { "start_pos": 59, "end_pos": 59, "sequence_org": "F", "sequence_mut": "D", "comment": "Loss of JAK signal transduction suppression. Destabilization of SOCS1.", "evidence": [ { "database": "UniProtKB", "id": "O35716", "url": "https://www.uniprot.org/uniprotkb/O35716" }, { "database": "PubMed", "id": "10064597", "url": "https://pubmed.ncbi.nlm.nih.gov/10064597" }, { "database": "PubMed", "id": "11522790", "url": "https://pubmed.ncbi.nlm.nih.gov/11522790" } ], "uniprot_canonical_ac": "O35716-1" }, { "start_pos": 59, "end_pos": 59, "sequence_org": "F", "sequence_mut": "E", "comment": "Loss of JAK signal transduction suppression. Reduced binding to JH1.", "evidence": [ { "database": "UniProtKB", "id": "O35716", "url": "https://www.uniprot.org/uniprotkb/O35716" }, { "database": "PubMed", "id": "10064597", "url": "https://pubmed.ncbi.nlm.nih.gov/10064597" }, { "database": "PubMed", "id": "11522790", "url": "https://pubmed.ncbi.nlm.nih.gov/11522790" } ], "uniprot_canonical_ac": "O35716-1" }, { "start_pos": 59, "end_pos": 59, "sequence_org": "F", "sequence_mut": "L", "comment": "No effect on JAK signal transduction suppression nor on binding to JH1.", "evidence": [ { "database": "UniProtKB", "id": "O35716", "url": "https://www.uniprot.org/uniprotkb/O35716" }, { "database": "PubMed", "id": "10064597", "url": "https://pubmed.ncbi.nlm.nih.gov/10064597" }, { "database": "PubMed", "id": "11522790", "url": "https://pubmed.ncbi.nlm.nih.gov/11522790" } ], "uniprot_canonical_ac": "O35716-1" }, { "start_pos": 60, "end_pos": 60, "sequence_org": "R", "sequence_mut": "A", "comment": "No effect on LIF signal transduction suppression.", "evidence": [ { "database": "UniProtKB", "id": "O35716", "url": "https://www.uniprot.org/uniprotkb/O35716" }, { "database": "PubMed", "id": "10064597", "url": "https://pubmed.ncbi.nlm.nih.gov/10064597" } ], "uniprot_canonical_ac": "O35716-1" }, { "start_pos": 61, "end_pos": 61, "sequence_org": "S", "sequence_mut": "E", "comment": "No effect on JAK signal transduction suppression.", "evidence": [ { "database": "UniProtKB", "id": "O35716", "url": "https://www.uniprot.org/uniprotkb/O35716" }, { "database": "PubMed", "id": "10064597", "url": "https://pubmed.ncbi.nlm.nih.gov/10064597" } ], "uniprot_canonical_ac": "O35716-1" }, { "start_pos": 62, "end_pos": 62, "sequence_org": "H", "sequence_mut": "E", "comment": "No effect on JAK signal transduction suppression.", "evidence": [ { "database": "UniProtKB", "id": "O35716", "url": "https://www.uniprot.org/uniprotkb/O35716" }, { "database": "PubMed", "id": "10064597", "url": "https://pubmed.ncbi.nlm.nih.gov/10064597" } ], "uniprot_canonical_ac": "O35716-1" }, { "start_pos": 64, "end_pos": 64, "sequence_org": "D", "sequence_mut": "R", "comment": "Loss of JAK signal transduction suppression. Reduced binding to JH1.", "evidence": [ { "database": "UniProtKB", "id": "O35716", "url": "https://www.uniprot.org/uniprotkb/O35716" }, { "database": "PubMed", "id": "10064597", "url": "https://pubmed.ncbi.nlm.nih.gov/10064597" } ], "uniprot_canonical_ac": "O35716-1" }, { "start_pos": 65, "end_pos": 65, "sequence_org": "Y", "sequence_mut": "A", "comment": "Some loss of JAK signal transduction signaling. 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"Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain.", "journal": "Genes to cells : devoted to molecular & cellular mechanisms", "date": "1999", "authors": "Sasaki A, Yasukawa H, Suzuki A, Kamizono S, Syoda T, Kinjyo I, Sasaki M, Johnston JA, Yoshimura A", "reference": { "type": "PubMed", "id": "10421843", "url": "https://pubmed.ncbi.nlm.nih.gov/10421843" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15524-1", "protein_name": "Suppressor of cytokine signaling 1", "gene_name": "SOCS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38484-1", "protein_name": "Interferon gamma receptor 2", "gene_name": "IFNGR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60674-1", "protein_name": "Tyrosine-protein kinase JAK2", "gene_name": "JAK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01579-1", "protein_name": "Interferon gamma", 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domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2000", "authors": "Liao J, Fu Y, Shuai K", "reference": { "type": "PubMed", "id": "10805787", "url": "https://pubmed.ncbi.nlm.nih.gov/10805787" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15524-1", "protein_name": "Suppressor of cytokine signaling 1", "gene_name": "SOCS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38484-1", "protein_name": "Interferon gamma receptor 2", "gene_name": "IFNGR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60674-1", "protein_name": "Tyrosine-protein kinase JAK2", "gene_name": "JAK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01579-1", "protein_name": "Interferon gamma", "gene_name": "IFNG", "tax_name": "Human" }, { 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}, { "uniprot_canonical_ac": "O14543-1", "protein_name": "Suppressor of cytokine signaling 3", "gene_name": "SOCS3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75925-1", "protein_name": "E3 SUMO-protein ligase PIAS1", "gene_name": "PIAS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P23458-1", "protein_name": "Tyrosine-protein kinase JAK1", "gene_name": "JAK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q24151-1", "protein_name": "Signal transducer and transcription activator", "gene_name": "Stat92E", "tax_name": "Fruit fly" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15524", "url": "https://www.uniprot.org/uniprotkb/O15524" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10805787", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": 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signaling.", "journal": "Stem Cells", "date": "2001", "authors": "Krebs DL, Hilton DJ", "reference": { "type": "PubMed", "id": "11553846", "url": "https://pubmed.ncbi.nlm.nih.gov/11553846" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15524-1", "protein_name": "Suppressor of cytokine signaling 1", "gene_name": "SOCS1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15524", "url": "https://www.uniprot.org/uniprotkb/O15524" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11553846", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": 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{ "uniprot_canonical_ac": "P29350-1", "protein_name": "Tyrosine-protein phosphatase non-receptor type 6", "gene_name": "PTPN6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P52630-3", "protein_name": "Signal transducer and activator of transcription 2", "gene_name": "STAT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UMW8-1", "protein_name": "Ubl carboxyl-terminal hydrolase 18", "gene_name": "USP18", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05014-1", "protein_name": "Interferon alpha-4", "gene_name": "IFNA4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06124-2", "protein_name": "Tyrosine-protein phosphatase non-receptor type 11", "gene_name": "PTPN11", "tax_name": "Human" }, { "uniprot_canonical_ac": "P29597-1", "protein_name": "Non-receptor tyrosine-protein kinase TYK2", "gene_name": "TYK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14543-1", "protein_name": "Suppressor of cytokine signaling 3", "gene_name": "SOCS3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0DY56-1", "protein_name": "Interferon alpha-1", "gene_name": "IFNA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01566-1", "protein_name": "Interferon alpha-10", "gene_name": "IFNA10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01571-1", "protein_name": "Interferon alpha-17", "gene_name": "IFNA17", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01574-1", "protein_name": "Interferon beta", "gene_name": "IFNB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05015-1", "protein_name": "Interferon alpha-16", "gene_name": "IFNA16", "tax_name": "Human" }, { "uniprot_canonical_ac": "P23458-1", "protein_name": "Tyrosine-protein kinase JAK1", "gene_name": "JAK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P17181-1", "protein_name": "Interferon alpha/beta receptor 1", "gene_name": "IFNAR1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15524", "url": "https://www.uniprot.org/uniprotkb/O15524" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11694501", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 23 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], 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in it?", "journal": "J. Neurosci. Res.", "date": "2002", "authors": "Wang Jianping, Campbell Iain L", "reference": { "type": "PubMed", "id": "11835308", "url": "https://pubmed.ncbi.nlm.nih.gov/11835308" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15524-1", "protein_name": "Suppressor of cytokine signaling 1", "gene_name": "SOCS1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15524", "url": "https://www.uniprot.org/uniprotkb/O15524" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11835308", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "TRIM8/GERP RING finger protein interacts with SOCS-1.", "journal": "J. Biol. Chem.", "date": "2002", "authors": "Toniato E, Chen XP, Losman J, Flati V, Donahue L, Rothman P", "reference": { "type": "PubMed", "id": "12163497", "url": "https://pubmed.ncbi.nlm.nih.gov/12163497" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15524-1", "protein_name": "Suppressor of cytokine signaling 1", "gene_name": "SOCS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99PJ2-1", "protein_name": "E3 ubiquitin-protein ligase TRIM8", "gene_name": "Trim8", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "O35716-1", "protein_name": "Suppressor of cytokine signaling 1", "gene_name": "Socs1", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BZR9-1", "protein_name": "E3 ubiquitin-protein ligase TRIM8", "gene_name": "TRIM8", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15524", "url": "https://www.uniprot.org/uniprotkb/O15524" } ], "common_name": "Human", 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "PIAS proteins promote SUMO-1 conjugation to STAT1.", "journal": "Blood", "date": "2003", "authors": "Ungureanu D, Vanhatupa S, Kotaja N, Yang J, 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Allergy Clin. 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"count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1.", "journal": "Molecular and cellular biology", "date": "1996", "authors": "Jiao H, Berrada K, Yang W, Tabrizi M, Platanias LC, Yi T", "reference": { "type": "PubMed", "id": "8943354", "url": "https://pubmed.ncbi.nlm.nih.gov/8943354" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15524-1", "protein_name": "Suppressor of cytokine signaling 1", "gene_name": "SOCS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01563-1", "protein_name": "Interferon alpha-2", "gene_name": "IFNA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01567-1", "protein_name": "Interferon alpha-7", "gene_name": "IFNA7", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01568-1", "protein_name": "Interferon alpha-21", "gene_name": "IFNA21", 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"uniprot_canonical_ac": "O15524-1", "protein_name": "Suppressor of cytokine signaling 1", "gene_name": "SOCS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00560-1", "protein_name": "Interleukin-6 receptor subunit beta", "gene_name": "Il6st", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "O35717-1", "protein_name": "Suppressor of cytokine signaling 2", "gene_name": "Socs2", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "O35716-1", "protein_name": "Suppressor of cytokine signaling 1", "gene_name": "Socs1", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "O35718-1", "protein_name": "Suppressor of cytokine signaling 3", "gene_name": "Socs3", "tax_name": "Mouse" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15524", "url": "https://www.uniprot.org/uniprotkb/O15524" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.9202125", "abstract": "", 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N, Taniguchi T, Fujita T, Kanakura Y, Komiya S, Yoshimura A", "reference": { "type": "PubMed", "id": "9202126", "url": "https://pubmed.ncbi.nlm.nih.gov/9202126" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15524-1", "protein_name": "Suppressor of cytokine signaling 1", "gene_name": "SOCS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O35716-1", "protein_name": "Suppressor of cytokine signaling 1", "gene_name": "Socs1", "tax_name": "Mouse" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15524", "url": "https://www.uniprot.org/uniprotkb/O15524" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.9202126", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], 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"count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3.", "journal": "Biochem. Biophys. Res. Commun.", "date": "1997", "authors": "Minamoto S, Ikegame K, Ueno K, Narazaki M, Naka T, Yamamoto H, Matsumoto T, Saito H, Hosoe S, Kishimoto T", "reference": { "type": "PubMed", "id": "9266833", "url": "https://pubmed.ncbi.nlm.nih.gov/9266833" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15524-1", "protein_name": "Suppressor of cytokine signaling 1", "gene_name": "SOCS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14508-1", "protein_name": "Suppressor of cytokine signaling 2", "gene_name": "SOCS2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14543-1", "protein_name": "Suppressor of cytokine signaling 3", "gene_name": "SOCS3", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15524", "url": "https://www.uniprot.org/uniprotkb/O15524" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": 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}, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase.", "journal": "The Journal of biological chemistry", "date": "1997-10-24", "authors": "Ohya K i, Kajigaya S, Yamashita Y, Miyazato A, Hatake K, Miura Y, Ikeda U, Shimada K, Ozawa K, Mano H", "reference": { "type": "PubMed", "id": "9341160", "url": "https://pubmed.ncbi.nlm.nih.gov/9341160" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15524-1", "protein_name": "Suppressor of cytokine signaling 1", "gene_name": "SOCS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42680-1", "protein_name": "Tyrosine-protein kinase Tec", "gene_name": "TEC", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15524", "url": "https://www.uniprot.org/uniprotkb/O15524" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.9341160", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", 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], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophages.", "journal": "Current biology : CB", "date": "1999", "authors": "Timms JF, Swanson KD, Marie-Cardine A, Raab M, Rudd CE, Schraven B, Neel BG", "reference": { "type": "PubMed", "id": "10469599", "url": "https://pubmed.ncbi.nlm.nih.gov/10469599" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9P1W8-1", "protein_name": "Signal-regulatory protein gamma", "gene_name": 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"uniprot_canonical_ac": "P29350-1", "protein_name": "Tyrosine-protein phosphatase non-receptor type 6", "gene_name": "PTPN6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00241-1", "protein_name": "Signal-regulatory protein beta-1", "gene_name": "SIRPB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35247-1", "protein_name": "Pulmonary surfactant-associated protein D", "gene_name": "SFTPD", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06124-2", "protein_name": "Tyrosine-protein phosphatase non-receptor type 11", "gene_name": "PTPN11", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15117-1", "protein_name": "FYN-binding protein 1", "gene_name": "FYB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43914-1", "protein_name": "TYRO protein tyrosine kinase-binding protein", "gene_name": "TYROBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9QVP9-1", "protein_name": "Protein-tyrosine kinase 2-beta", "gene_name": "Ptk2b", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "P78324-1", "protein_name": "Tyrosine-protein phosphatase non-receptor type substrate 1", "gene_name": "SIRPA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14289-1", "protein_name": "Protein-tyrosine kinase 2-beta", "gene_name": "PTK2B", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9P1W8", "url": "https://www.uniprot.org/uniprotkb/Q9P1W8" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10469599", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 17 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, 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Hum. Genet.", "date": "2000", "authors": "Ichigotani Y, Matsuda S, Machida K, Oshima K, Iwamoto T, Yamaki K, Hayakawa T, Hamaguchi M", "reference": { "type": "PubMed", "id": "11185750", "url": "https://pubmed.ncbi.nlm.nih.gov/11185750" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9P1W8-1", "protein_name": "Signal-regulatory protein gamma", "gene_name": "SIRPG", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9P1W8", "url": "https://www.uniprot.org/uniprotkb/Q9P1W8" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11185750", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", 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{ "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "SHPS-1, a multifunctional transmembrane glycoprotein.", "journal": "FEBS letters", "date": "2002", "authors": "Oshima K, Ruhul Amin AR, Suzuki A, Hamaguchi M, Matsuda S", "reference": { "type": "PubMed", "id": "12023008", "url": "https://pubmed.ncbi.nlm.nih.gov/12023008" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9P1W8-1", "protein_name": "Signal-regulatory protein gamma", "gene_name": "SIRPG", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q08722-1", "protein_name": "Leukocyte surface 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"field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { 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"date": "2003", "authors": "Gardai SJ, Xiao YQ, Dickinson M, Nick JA, Voelker DR, Greene KE, Henson PM", "reference": { "type": "PubMed", "id": "14531999", "url": "https://pubmed.ncbi.nlm.nih.gov/14531999" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9P1W8-1", "protein_name": "Signal-regulatory protein gamma", "gene_name": "SIRPG", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q08722-1", "protein_name": "Leukocyte surface antigen CD47", "gene_name": "CD47", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75563-1", "protein_name": "Src kinase-associated phosphoprotein 2", "gene_name": "SKAP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IWL1-1", "protein_name": "Pulmonary surfactant-associated protein A2", "gene_name": "SFTPA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q05397-1", "protein_name": "Focal adhesion kinase 1", "gene_name": "PTK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IWL2-1", "protein_name": 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