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for lipid droplet localization, caspase-dependent apoptosis, and dimerization with CIDEA.", "journal": "American journal of physiology. 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"uniprot_canonical_ac": "P27986-1", "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit alpha", "gene_name": "PIK3R1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19174-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1", "gene_name": "PLCG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P06241-1", "protein_name": "Tyrosine-protein kinase Fyn", "gene_name": "FYN", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P01112", "url": "https://www.uniprot.org/uniprotkb/P01112" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10021361", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 25 } ], "sort_fields": [ 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], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT.", "journal": "The Journal of experimental medicine", "date": "1999", "authors": "Asada H, Ishii N, Sasaki Y, Endo K, Kasai H, Tanaka N, Takeshita T, Tsuchiya S, Konno T, Sugamura K", "reference": { "type": "PubMed", "id": "10224278", "url": "https://pubmed.ncbi.nlm.nih.gov/10224278" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P43405-1", "protein_name": "Tyrosine-protein kinase SYK", "gene_name": "SYK", "tax_name": "Human" }, { "uniprot_canonical_ac": "P26717-1", "protein_name": "NKG2-C type II integral membrane protein", "gene_name": "KLRC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42336-1", "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform", "gene_name": "PIK3CA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P26718-1", "protein_name": "NKG2-D type II integral membrane protein", "gene_name": "KLRK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01111-1", "protein_name": "GTPase NRas", "gene_name": "NRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P13747-1", "protein_name": "HLA class I histocompatibility antigen, alpha chain E", "gene_name": "HLA-E", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75791-1", "protein_name": "GRB2-related adapter protein 2", "gene_name": "GRAP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13241-1", "protein_name": "Natural killer cells antigen CD94", "gene_name": "KLRD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q07889-1", "protein_name": "Son of sevenless homolog 1", "gene_name": "SOS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06187-1", "protein_name": "Tyrosine-protein kinase BTK", "gene_name": "BTK", "tax_name": "Human" }, { "uniprot_canonical_ac": "P52735-1", "protein_name": "Guanine nucleotide exchange factor VAV2", "gene_name": "VAV2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61769-1", "protein_name": "Beta-2-microglobulin", "gene_name": "B2M", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63000-1", "protein_name": "Ras-related C3 botulinum toxin substrate 1", "gene_name": "RAC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00459-1", "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit beta", "gene_name": "PIK3R2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P06239-1", "protein_name": "Tyrosine-protein kinase Lck", "gene_name": "LCK", "tax_name": "Human" }, { "uniprot_canonical_ac": "P16885-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2", "gene_name": "PLCG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UKW4-1", "protein_name": "Guanine nucleotide exchange factor VAV3", "gene_name": "VAV3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42338-1", "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform", "gene_name": "PIK3CB", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43914-1", "protein_name": "TYRO protein tyrosine kinase-binding protein", "gene_name": "TYROBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NZC2-1", "protein_name": "Triggering receptor expressed on myeloid cells 2", "gene_name": "TREM2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13094-1", "protein_name": "Lymphocyte cytosolic protein 2", "gene_name": "LCP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27986-1", "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit alpha", "gene_name": "PIK3R1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19174-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1", "gene_name": "PLCG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P06241-1", "protein_name": "Tyrosine-protein kinase Fyn", "gene_name": "FYN", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P01112", "url": "https://www.uniprot.org/uniprotkb/P01112" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10224278", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 25 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans.", "journal": "J. Biol. Chem.", "date": "1999", "authors": "Liao Y, Kariya K, Hu CD, Shibatohge M, Goshima M, Okada T, Watari Y, Gao X, Jin TG, Yamawaki-Kataoka Y, Kataoka T", "reference": { "type": "PubMed", "id": "10608844", "url": "https://pubmed.ncbi.nlm.nih.gov/10608844" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62834-1", "protein_name": "Ras-related protein Rap-1A", "gene_name": "RAP1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y4G8-1", "protein_name": "Rap guanine nucleotide exchange factor 2", "gene_name": "RAPGEF2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P01112", "url": "https://www.uniprot.org/uniprotkb/P01112" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10608844", 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"10744696", "url": "https://pubmed.ncbi.nlm.nih.gov/10744696" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P43405-1", "protein_name": "Tyrosine-protein kinase SYK", "gene_name": "SYK", "tax_name": "Human" }, { "uniprot_canonical_ac": "P26717-1", "protein_name": "NKG2-C type II integral membrane protein", "gene_name": "KLRC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42336-1", "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform", "gene_name": "PIK3CA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P26718-1", "protein_name": "NKG2-D type II integral membrane protein", "gene_name": "KLRK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01111-1", "protein_name": "GTPase NRas", "gene_name": "NRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P13747-1", "protein_name": "HLA class I histocompatibility antigen, alpha chain E", "gene_name": "HLA-E", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75791-1", "protein_name": "GRB2-related adapter protein 2", "gene_name": "GRAP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13241-1", "protein_name": "Natural killer cells antigen CD94", "gene_name": "KLRD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q07889-1", "protein_name": "Son of sevenless homolog 1", "gene_name": "SOS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06187-1", "protein_name": "Tyrosine-protein kinase BTK", "gene_name": "BTK", "tax_name": "Human" }, { "uniprot_canonical_ac": "P52735-1", "protein_name": "Guanine nucleotide exchange factor VAV2", "gene_name": "VAV2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61769-1", "protein_name": "Beta-2-microglobulin", "gene_name": "B2M", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63000-1", "protein_name": "Ras-related C3 botulinum toxin substrate 1", "gene_name": "RAC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00459-1", "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit beta", "gene_name": "PIK3R2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P06239-1", "protein_name": "Tyrosine-protein kinase Lck", "gene_name": "LCK", "tax_name": "Human" }, { "uniprot_canonical_ac": "P16885-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2", "gene_name": "PLCG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UKW4-1", "protein_name": "Guanine nucleotide exchange factor VAV3", "gene_name": "VAV3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42338-1", "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform", "gene_name": "PIK3CB", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43914-1", "protein_name": "TYRO protein tyrosine kinase-binding protein", "gene_name": "TYROBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NZC2-1", "protein_name": "Triggering receptor expressed on myeloid cells 2", "gene_name": "TREM2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13094-1", "protein_name": "Lymphocyte cytosolic protein 2", "gene_name": "LCP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27986-1", "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit alpha", "gene_name": "PIK3R1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19174-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1", "gene_name": "PLCG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P06241-1", "protein_name": "Tyrosine-protein kinase Fyn", "gene_name": "FYN", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P01112", "url": "https://www.uniprot.org/uniprotkb/P01112" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10744696", 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Takimoto M, Kondo S, Katoh H, Kuzumaki N", "reference": { "type": "PubMed", "id": "10757026", "url": "https://pubmed.ncbi.nlm.nih.gov/10757026" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P01112", "url": "https://www.uniprot.org/uniprotkb/P01112" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10757026", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], 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}, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Ohba Y, Mochizuki N, Yamashita S, Chan AM, Schrader JW, Hattori S, Nagashima K, Matsuda M", "reference": { "type": "PubMed", "id": "10777492", "url": "https://pubmed.ncbi.nlm.nih.gov/10777492" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01111-1", "protein_name": "GTPase NRas", "gene_name": "NRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9QUG9-1", "protein_name": "RAS guanyl-releasing protein 2", "gene_name": "Rasgrp2", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "O95267-1", "protein_name": "RAS guanyl-releasing protein 1", "gene_name": "RASGRP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IV61-1", "protein_name": "Ras guanyl-releasing protein 3", "gene_name": "RASGRP3", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P01112", "url": "https://www.uniprot.org/uniprotkb/P01112" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10777492", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 5 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": 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"n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "CalDAG-GEFIII activation of Ras, R-ras, and Rap1.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Yamashita S, Mochizuki N, Ohba Y, Tobiume M, Okada Y, Sawa H, Nagashima K, Matsuda M", "reference": { "type": "PubMed", "id": "10835426", "url": "https://pubmed.ncbi.nlm.nih.gov/10835426" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01111-1", "protein_name": "GTPase NRas", "gene_name": "NRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9QUG9-1", "protein_name": "RAS guanyl-releasing protein 2", "gene_name": "Rasgrp2", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "O95267-1", "protein_name": "RAS guanyl-releasing protein 1", "gene_name": "RASGRP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IV61-1", "protein_name": "Ras guanyl-releasing protein 3", "gene_name": "RASGRP3", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P01112", "url": "https://www.uniprot.org/uniprotkb/P01112" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10835426", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 5 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Rebhun JF, Castro AF, Quilliam LA", "reference": { "type": "PubMed", "id": "10934204", "url": "https://pubmed.ncbi.nlm.nih.gov/10934204" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01111-1", "protein_name": "GTPase NRas", "gene_name": "NRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92565-1", "protein_name": "Rap guanine nucleotide exchange factor 5", "gene_name": "RAPGEF5", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95267-1", "protein_name": "RAS guanyl-releasing protein 1", "gene_name": "RASGRP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IV61-1", "protein_name": "Ras guanyl-releasing protein 3", "gene_name": "RASGRP3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y4G8-1", "protein_name": "Rap guanine nucleotide exchange factor 2", "gene_name": "RAPGEF2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P01112", "url": "https://www.uniprot.org/uniprotkb/P01112" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10934204", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 6 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Song C, Hu CD, Masago M, Kariyai K, Yamawaki-Kataoka Y, Shibatohge M, Wu D, Satoh T, Kataoka T", "reference": { "type": "PubMed", "id": "11022048", "url": "https://pubmed.ncbi.nlm.nih.gov/11022048" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P51178-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1", "gene_name": "PLCD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92835-1", "protein_name": "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1", "gene_name": "INPP5D", "tax_name": "Human" }, { "uniprot_canonical_ac": "P23677-1", "protein_name": "Inositol-trisphosphate 3-kinase A", "gene_name": "ITPKA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00722-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2", "gene_name": "PLCB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BRC7-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4", "gene_name": "PLCD4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86YW0-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1", "gene_name": "PLCZ1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9P212-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1", "gene_name": "PLCE1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62834-1", "protein_name": "Ras-related protein Rap-1A", "gene_name": "RAP1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15735-1", "protein_name": "Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A", "gene_name": "INPP5J", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0DP23-1", "protein_name": "Calmodulin-1", "gene_name": "CALM1; CALM2; CALM3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQ66-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1", "gene_name": "PLCB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75038-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2", "gene_name": "PLCH2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q4KWH8-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1", "gene_name": "PLCH1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15357-1", "protein_name": "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2", "gene_name": "INPPL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P16885-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2", "gene_name": "PLCG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q01968-1", "protein_name": "Inositol polyphosphate 5-phosphatase OCRL", "gene_name": "OCRL", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27987-1", "protein_name": "Inositol-trisphosphate 3-kinase B", "gene_name": "ITPKB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P60484-1", "protein_name": "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN", "gene_name": "PTEN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15147-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4", "gene_name": "PLCB4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N3E9-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3", "gene_name": "PLCD3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q01970-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3", "gene_name": "PLCB3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96BZ4-1", "protein_name": "5'-3' exonuclease PLD4", "gene_name": "PLD4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43426-1", "protein_name": "Polyphosphatidylinositol phosphatase SYNJ1", "gene_name": "SYNJ1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96DU7-1", "protein_name": "Inositol-trisphosphate 3-kinase C", "gene_name": "ITPKC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13572-1", "protein_name": "Inositol-tetrakisphosphate 1-kinase", "gene_name": "ITPK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P32019-1", "protein_name": "Type II inositol 1,4,5-trisphosphate 5-phosphatase", "gene_name": "INPP5B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19174-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1", "gene_name": "PLCG1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P01112", "url": "https://www.uniprot.org/uniprotkb/P01112" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 17, "end_pos": 17, "sequence_org": "S", "sequence_mut": "N", "comment": "Dominant negative. Prevents PLCE1 EGF-induced recruitment to plasma membrane. No effect on subcellular location of isoform 2.", "evidence": [ { "database": "UniProtKB", "id": "P01112", "url": "https://www.uniprot.org/uniprotkb/P01112" }, { "database": "PubMed", "id": "14500341", "url": "https://pubmed.ncbi.nlm.nih.gov/14500341" }, { "database": "PubMed", "id": "11022048", "url": "https://pubmed.ncbi.nlm.nih.gov/11022048" } ], "uniprot_canonical_ac": "P01112-1" }, { "start_pos": 26, "end_pos": 26, "sequence_org": "N", "sequence_mut": "G", "comment": "Loss of interaction with PLCE1; when associated with V-12.", "evidence": [ { "database": "UniProtKB", "id": "P01112", "url": "https://www.uniprot.org/uniprotkb/P01112" }, { "database": "PubMed", "id": "11022048", "url": "https://pubmed.ncbi.nlm.nih.gov/11022048" } ], "uniprot_canonical_ac": "P01112-1" }, { "start_pos": 29, "end_pos": 29, "sequence_org": "V", "sequence_mut": "A", "comment": "No effect on interaction with PLCE1; when associated with V-12.", "evidence": [ { "database": "UniProtKB", "id": "P01112", "url": "https://www.uniprot.org/uniprotkb/P01112" }, { "database": "PubMed", "id": "11022048", "url": "https://pubmed.ncbi.nlm.nih.gov/11022048" } ], "uniprot_canonical_ac": "P01112-1" }, { "start_pos": 32, "end_pos": 32, "sequence_org": "Y", "sequence_mut": "F", "comment": "Loss of interaction and recruitment to plasma membrane of PLCE1; when associated with V-12.", "evidence": [ { "database": "UniProtKB", "id": "P01112", "url": "https://www.uniprot.org/uniprotkb/P01112" }, { "database": "PubMed", "id": "11022048", "url": "https://pubmed.ncbi.nlm.nih.gov/11022048" } ], "uniprot_canonical_ac": "P01112-1" }, { "start_pos": 34, "end_pos": 34, "sequence_org": "P", "sequence_mut": "G", "comment": "No effect on interaction with PLCE1; when associated with V-12.", "evidence": [ { "database": "UniProtKB", "id": "P01112", "url": "https://www.uniprot.org/uniprotkb/P01112" }, { "database": "PubMed", "id": "11022048", "url": "https://pubmed.ncbi.nlm.nih.gov/11022048" } ], "uniprot_canonical_ac": "P01112-1" }, { "start_pos": 35, "end_pos": 35, "sequence_org": "T", "sequence_mut": "S", "comment": "Loss of interaction with PLCE1; when associated with V-12.", "evidence": [ { "database": "UniProtKB", "id": "P01112", "url": "https://www.uniprot.org/uniprotkb/P01112" }, { "database": "PubMed", "id": "11022048", "url": "https://pubmed.ncbi.nlm.nih.gov/11022048" } ], "uniprot_canonical_ac": "P01112-1" }, { "start_pos": 37, "end_pos": 37, "sequence_org": "E", "sequence_mut": "G", "comment": "No effect on interaction with PLCE1; when associated with V-12.", "evidence": [ { "database": "UniProtKB", "id": "P01112", "url": "https://www.uniprot.org/uniprotkb/P01112" }, { "database": "PubMed", "id": "11022048", "url": "https://pubmed.ncbi.nlm.nih.gov/11022048" } ], "uniprot_canonical_ac": "P01112-1" }, { "start_pos": 38, "end_pos": 38, "sequence_org": "D", "sequence_mut": "N", "comment": "No effect on interaction with PLCE1; when associated with V-12.", "evidence": [ { "database": 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"uniprot_canonical_ac": "P08941-1", "protein_name": "Proto-oncogene tyrosine-protein kinase ROS", "gene_name": "ROS1", "tax_name": "Chicken" }, { "uniprot_canonical_ac": "Q13094-1", "protein_name": "Lymphocyte cytosolic protein 2", "gene_name": "LCP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27986-1", "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit alpha", "gene_name": "PIK3R1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19174-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1", "gene_name": "PLCG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P06241-1", "protein_name": "Tyrosine-protein kinase Fyn", "gene_name": "FYN", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P01112", "url": "https://www.uniprot.org/uniprotkb/P01112" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], 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"total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Rap1 is activated by erythropoietin or interleukin-3 and is involved in regulation of beta1 integrin-mediated hematopoietic cell adhesion.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Arai A, Nosaka Y, Kanda E, Yamamoto K, Miyasaka N, Miura O", "reference": { "type": "PubMed", "id": "11124936", "url": "https://pubmed.ncbi.nlm.nih.gov/11124936" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60674-1", "protein_name": "Tyrosine-protein kinase JAK2", "gene_name": "JAK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01111-1", "protein_name": "GTPase NRas", "gene_name": "NRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19235-1", "protein_name": "Erythropoietin receptor", "gene_name": "EPOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q07889-1", "protein_name": "Son of sevenless homolog 1", "gene_name": "SOS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13905-1", "protein_name": "Rap guanine nucleotide exchange factor 1", "gene_name": "RAPGEF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46109-1", "protein_name": "Crk-like protein", "gene_name": "CRKL", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y4H2-1", "protein_name": "Insulin receptor substrate 2", "gene_name": "IRS2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P07948-1", "protein_name": "Tyrosine-protein kinase Lyn", "gene_name": "LYN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01588-1", "protein_name": "Erythropoietin", "gene_name": "EPO", "tax_name": "Human" }, { "uniprot_canonical_ac": "P29353-1", "protein_name": "SHC-transforming protein 1", "gene_name": "SHC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15498-1", "protein_name": "Proto-oncogene vav", "gene_name": "VAV1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P01112", "url": "https://www.uniprot.org/uniprotkb/P01112" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], 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}, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism.", "journal": "J. Cell Biol.", "date": "2001", "authors": "Topham M K, Prescott S M", "reference": { "type": "PubMed", "id": "11257115", "url": "https://pubmed.ncbi.nlm.nih.gov/11257115" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13574-2", "protein_name": "Diacylglycerol kinase zeta", "gene_name": "DGKZ", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95267-1", "protein_name": "RAS guanyl-releasing protein 1", "gene_name": "RASGRP1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P01112", "url": "https://www.uniprot.org/uniprotkb/P01112" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11257115", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": 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Biol. Chem.", "date": "2001", "authors": "Pham N, Rotin D", "reference": { "type": "PubMed", "id": "11598133", "url": "https://pubmed.ncbi.nlm.nih.gov/11598133" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46934-1", "protein_name": "E3 ubiquitin-protein ligase NEDD4", "gene_name": "NEDD4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y4G8-1", "protein_name": "Rap guanine nucleotide exchange factor 2", "gene_name": "RAPGEF2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P01112", "url": "https://www.uniprot.org/uniprotkb/P01112" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 1406, "end_pos": 1406, "sequence_org": "Y", "sequence_mut": "A", "comment": "Abolishes interaction with NEDD4 and NEDD4-induced ubiquitination and degradation; when associated with A-1428.", "evidence": [ { "database": "UniProtKB", "id": "Q9Y4G8", "url": "https://www.uniprot.org/uniprotkb/Q9Y4G8" }, { "database": "PubMed", "id": "11598133", "url": "https://pubmed.ncbi.nlm.nih.gov/11598133" } ], "uniprot_canonical_ac": "Q9Y4G8-1" }, { "start_pos": 1428, "end_pos": 1428, "sequence_org": "Y", "sequence_mut": "A", "comment": "Abolishes interaction with NEDD4 and NEDD4-induced ubiquitination and degradation; when associated with A-1406.", "evidence": [ { "database": "UniProtKB", "id": "Q9Y4G8", "url": "https://www.uniprot.org/uniprotkb/Q9Y4G8" }, { "database": "PubMed", "id": "11598133", "url": "https://pubmed.ncbi.nlm.nih.gov/11598133" } ], "uniprot_canonical_ac": "Q9Y4G8-1" }, { "start_pos": 898, "end_pos": 898, "sequence_org": "R", "sequence_mut": "D", "comment": "Does not inhibit interaction with NEDD4. 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biochemical studies of p21Ras S-nitrosylation and nitric oxide-mediated guanine nucleotide exchange.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2003", "authors": "Williams JG, Pappu K, Campbell SL", "reference": { "type": "PubMed", "id": "12740440", "url": "https://pubmed.ncbi.nlm.nih.gov/12740440" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P01112", "url": "https://www.uniprot.org/uniprotkb/P01112" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 118, "end_pos": 118, "sequence_org": "C", "sequence_mut": "S", "comment": "Abolishes S-nitrosylation. No stimulation of guanine nucleotide exchange.", "evidence": [ { "database": "UniProtKB", "id": "P01112", "url": "https://www.uniprot.org/uniprotkb/P01112" }, { "database": "PubMed", "id": "9020151", "url": "https://pubmed.ncbi.nlm.nih.gov/9020151" }, { "database": "PubMed", "id": "12740440", "url": "https://pubmed.ncbi.nlm.nih.gov/12740440" } ], "uniprot_canonical_ac": "P01112-1" } ], "record_id": "pubmed.12740440", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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"glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Erythropoietin rapidly induces tyrosine phosphorylation in the human erythropoietin-dependent cell line, UT-7.", "journal": "Blood", "date": "1992", "authors": "Komatsu N, Adamson JW, Yamamoto K, Altschuler D, Torti M, Marzocchini R, Lapetina EG", "reference": { "type": "PubMed", "id": "1377053", "url": "https://pubmed.ncbi.nlm.nih.gov/1377053" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60674-1", "protein_name": "Tyrosine-protein kinase JAK2", "gene_name": "JAK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01111-1", "protein_name": "GTPase NRas", "gene_name": "NRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19235-1", "protein_name": "Erythropoietin receptor", "gene_name": "EPOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q07889-1", "protein_name": "Son of sevenless homolog 1", "gene_name": "SOS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13905-1", "protein_name": "Rap guanine nucleotide exchange factor 1", 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"Sakai E, Rikimaru K, Ueda M, Matsumoto Y, Ishii N, Enomoto S, Yamamoto H, Tsuchida N", "reference": { "type": "PubMed", "id": "1459726", "url": "https://pubmed.ncbi.nlm.nih.gov/1459726" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04637-1", "protein_name": "Cellular tumor antigen p53", "gene_name": "TP53", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P01112", "url": "https://www.uniprot.org/uniprotkb/P01112" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.1459726", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], 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"date": "1992", "authors": "Torti M, Marti KB, Altschuler D, Yamamoto K, Lapetina EG", "reference": { "type": "PubMed", "id": "1569084", "url": "https://pubmed.ncbi.nlm.nih.gov/1569084" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60674-1", "protein_name": "Tyrosine-protein kinase JAK2", "gene_name": "JAK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01111-1", "protein_name": "GTPase NRas", "gene_name": "NRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19235-1", "protein_name": "Erythropoietin receptor", "gene_name": "EPOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q07889-1", "protein_name": "Son of sevenless homolog 1", "gene_name": "SOS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13905-1", "protein_name": "Rap guanine nucleotide exchange factor 1", "gene_name": "RAPGEF1", "tax_name": "Human" }, { 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J.", "date": "2006", "authors": "Klink BU, Goody RS, Scheidig AJ", "reference": { "type": "PubMed", "id": "16698776", "url": "https://pubmed.ncbi.nlm.nih.gov/16698776" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P01112", "url": "https://www.uniprot.org/uniprotkb/P01112" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.16698776", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": 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"journal": "Current opinion in genetics & development", "date": "2007", "authors": "Mohi MG, Neel BG", "reference": { "type": "PubMed", "id": "17227708", "url": "https://pubmed.ncbi.nlm.nih.gov/17227708" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15520-1", "protein_name": "Fibroblast growth factor 10", "gene_name": "FGF10", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WU20-1", "protein_name": "Fibroblast growth factor receptor substrate 2", "gene_name": "FRS2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01111-1", "protein_name": "GTPase NRas", "gene_name": "NRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09038-4", "protein_name": "Fibroblast growth factor 2", "gene_name": "FGF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q07889-1", "protein_name": "Son of sevenless homolog 1", "gene_name": "SOS1", 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