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"count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1.", "journal": "Cell", "date": "2001", "authors": "Habas R, Kato Y, He X", "reference": { "type": "PubMed", "id": "11779461", "url": "https://pubmed.ncbi.nlm.nih.gov/11779461" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P61586-1", "protein_name": "Transforming protein RhoA", "gene_name": "RHOA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5S8-1", "protein_name": "NADPH oxidase 1", "gene_name": "NOX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y4D1-1", "protein_name": "Disheveled-associated activator of morphogenesis 1", "gene_name": "DAAM1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O96014-1", "protein_name": "Protein Wnt-11", "gene_name": "WNT11", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60353-1", "protein_name": "Frizzled-6", "gene_name": "FZD6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75084-1", "protein_name": "Frizzled-7", "gene_name": "FZD7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UP38-1", "protein_name": "Frizzled-1", "gene_name": "FZD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P07737-1", "protein_name": "Profilin-1", "gene_name": "PFN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14640-1", "protein_name": "Segment polarity protein dishevelled homolog DVL-1", "gene_name": "DVL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14641-1", "protein_name": "Segment polarity protein dishevelled homolog DVL-2", "gene_name": "DVL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63000-1", "protein_name": "Ras-related C3 botulinum toxin substrate 1", "gene_name": "RAC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P13498-1", "protein_name": "Cytochrome b-245 light chain", "gene_name": "CYBA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFA2-1", "protein_name": "NADPH oxidase organizer 1", "gene_name": "NOXO1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NPG1-1", "protein_name": "Frizzled-3", "gene_name": "FZD3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56705-1", "protein_name": "Protein Wnt-4", "gene_name": "WNT4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P41221-1", "protein_name": "Protein Wnt-5a", "gene_name": "WNT5A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P45983-1", "protein_name": "Mitogen-activated protein kinase 8", "gene_name": "MAPK8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15153-1", "protein_name": "Ras-related C3 botulinum toxin substrate 2", "gene_name": "RAC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9ULK5-1", "protein_name": "Vang-like protein 2", "gene_name": "VANGL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P34925-1", "protein_name": "Inactive tyrosine-protein kinase RYK", "gene_name": "RYK", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04628-1", "protein_name": "Proto-oncogene Wnt-1", "gene_name": "WNT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P60763-1", "protein_name": "Ras-related C3 botulinum toxin substrate 3", "gene_name": "RAC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86UR1-1", "protein_name": "NADPH oxidase activator 1", "gene_name": "NOXA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H1J7-1", "protein_name": "Protein Wnt-5b", "gene_name": "WNT5B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05412-1", "protein_name": "Transcription factor Jun", "gene_name": "JUN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92997-1", "protein_name": "Segment polarity protein dishevelled homolog DVL-3", "gene_name": "DVL3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q01974-1", "protein_name": "Tyrosine-protein kinase transmembrane receptor ROR2", "gene_name": "ROR2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P61586", "url": "https://www.uniprot.org/uniprotkb/P61586" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11779461", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 27 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { 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"glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "MgF(3)(-) as a transition state analog of phosphoryl transfer.", "journal": "Chem. Biol.", "date": "2002", "authors": "Graham Debbie L, Lowe Peter N, Grime Geoffrey W, Marsh Michael, Rittinger Katrin, Smerdon Stephen J, Gamblin Steven J, Eccleston John F", "reference": { "type": "PubMed", "id": "11927263", "url": "https://pubmed.ncbi.nlm.nih.gov/11927263" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P61586-1", "protein_name": "Transforming protein RhoA", "gene_name": "RHOA", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P61586", "url": "https://www.uniprot.org/uniprotkb/P61586" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11927263", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ 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}, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.", "journal": "Nat. Struct. Biol.", "date": "2002", "authors": "Snyder JT, Worthylake DK, Rossman KL, Betts L, Pruitt WM, Siderovski DP, Der CJ, Sondek J", "reference": { "type": "PubMed", "id": "12006984", "url": "https://pubmed.ncbi.nlm.nih.gov/12006984" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P61586-1", "protein_name": "Transforming protein RhoA", "gene_name": "RHOA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q64096-1", "protein_name": "Guanine nucleotide exchange factor DBS", "gene_name": "Mcf2l", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q15811-1", "protein_name": "Intersectin-1", "gene_name": "ITSN1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P61586", "url": "https://www.uniprot.org/uniprotkb/P61586" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 1369, "end_pos": 1369, "sequence_org": "M", "sequence_mut": "L", "comment": "Decreases specificity for CDC42; when associated with I-1376.", "evidence": [ { "database": "UniProtKB", "id": "Q15811", "url": "https://www.uniprot.org/uniprotkb/Q15811" }, { "database": "PubMed", "id": "12006984", "url": "https://pubmed.ncbi.nlm.nih.gov/12006984" } ], "uniprot_canonical_ac": "Q15811-1" }, { "start_pos": 1376, "end_pos": 1376, "sequence_org": "L", "sequence_mut": "I", "comment": "Decreases specificity for CDC42; when associated with L-1369.", "evidence": [ { "database": "UniProtKB", "id": "Q15811", "url": "https://www.uniprot.org/uniprotkb/Q15811" }, { "database": "PubMed", "id": "12006984", "url": "https://pubmed.ncbi.nlm.nih.gov/12006984" } ], "uniprot_canonical_ac": "Q15811-1" } ], "record_id": "pubmed.12006984", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 3 } ], 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"count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling.", "journal": "Cell", "date": "2002", "authors": "Tree DR, Shulman JM, Rousset R, Scott MP, Gubb D, Axelrod JD", "reference": { "type": "PubMed", "id": "12015986", "url": "https://pubmed.ncbi.nlm.nih.gov/12015986" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P61586-1", "protein_name": "Transforming protein RhoA", "gene_name": "RHOA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5S8-1", "protein_name": "NADPH oxidase 1", "gene_name": "NOX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y4D1-1", "protein_name": "Disheveled-associated activator of morphogenesis 1", "gene_name": "DAAM1", "tax_name": "Human" }, { "uniprot_canonical_ac": "A1Z6W3-1", "protein_name": "Protein prickle", "gene_name": "pk", "tax_name": "Fruit fly" }, { "uniprot_canonical_ac": "O96014-1", "protein_name": "Protein Wnt-11", "gene_name": "WNT11", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60353-1", "protein_name": "Frizzled-6", "gene_name": "FZD6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75084-1", "protein_name": "Frizzled-7", "gene_name": "FZD7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UP38-1", "protein_name": "Frizzled-1", "gene_name": "FZD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P51140-1", "protein_name": "Segment polarity protein dishevelled", "gene_name": "dsh", "tax_name": "Fruit fly" }, { "uniprot_canonical_ac": "P07737-1", "protein_name": "Profilin-1", "gene_name": "PFN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14640-1", "protein_name": "Segment polarity protein dishevelled homolog DVL-1", "gene_name": "DVL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14641-1", "protein_name": "Segment polarity protein dishevelled homolog DVL-2", "gene_name": "DVL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63000-1", "protein_name": "Ras-related C3 botulinum toxin substrate 1", "gene_name": "RAC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P13498-1", "protein_name": "Cytochrome b-245 light chain", "gene_name": "CYBA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFA2-1", "protein_name": "NADPH oxidase organizer 1", "gene_name": "NOXO1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NPG1-1", "protein_name": "Frizzled-3", "gene_name": "FZD3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56705-1", "protein_name": "Protein Wnt-4", "gene_name": "WNT4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P41221-1", "protein_name": "Protein Wnt-5a", "gene_name": "WNT5A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P45983-1", "protein_name": "Mitogen-activated protein kinase 8", "gene_name": "MAPK8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15153-1", "protein_name": "Ras-related C3 botulinum toxin substrate 2", "gene_name": "RAC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9ULK5-1", "protein_name": "Vang-like protein 2", "gene_name": "VANGL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P34925-1", "protein_name": "Inactive tyrosine-protein kinase RYK", "gene_name": "RYK", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04628-1", "protein_name": "Proto-oncogene Wnt-1", "gene_name": "WNT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P60763-1", "protein_name": "Ras-related C3 botulinum toxin substrate 3", "gene_name": "RAC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86UR1-1", "protein_name": "NADPH oxidase activator 1", "gene_name": "NOXA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H1J7-1", "protein_name": "Protein Wnt-5b", "gene_name": "WNT5B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05412-1", "protein_name": "Transcription factor Jun", "gene_name": "JUN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92997-1", "protein_name": "Segment polarity protein dishevelled homolog DVL-3", "gene_name": "DVL3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q01974-1", "protein_name": "Tyrosine-protein kinase transmembrane receptor ROR2", "gene_name": "ROR2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P61586", "url": "https://www.uniprot.org/uniprotkb/P61586" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.12015986", "abstract": "", 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"o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Structure of a constitutively activated RhoA mutant (Q63L) at 1.55 A resolution.", "journal": "Acta Crystallogr. D", "date": "2003", "authors": "Longenecker K, Read P, Lin SK, Somlyo AP, Nakamoto RK, Derewenda ZS", "reference": { "type": "PubMed", "id": "12777804", "url": "https://pubmed.ncbi.nlm.nih.gov/12777804" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P61586-1", "protein_name": "Transforming protein RhoA", "gene_name": "RHOA", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P61586", "url": "https://www.uniprot.org/uniprotkb/P61586" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.12777804", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": 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"glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Citron kinase, a Rho-dependent kinase, induces di-phosphorylation of regulatory light chain of myosin II.", "journal": "Molecular biology of the cell", "date": "2003", "authors": "Yamashiro S, Totsukawa G, Yamakita Y, Sasaki Y, Madaule P, Ishizaki T, Narumiya S, Matsumura F", "reference": { "type": "PubMed", "id": "12802051", "url": "https://pubmed.ncbi.nlm.nih.gov/12802051" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P61586-1", "protein_name": "Transforming protein RhoA", "gene_name": "RHOA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08134-1", "protein_name": "Rho-related GTP-binding protein RhoC", "gene_name": "RHOC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P60660-1", "protein_name": "Myosin light polypeptide 6", "gene_name": "MYL6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35579-1", "protein_name": "Myosin-9", "gene_name": "MYH9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15058-1", "protein_name": "Kinesin-like protein KIF14", "gene_name": "KIF14", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43663-1", "protein_name": "Protein regulator of cytokinesis 1", "gene_name": "PRC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P78352-1", "protein_name": "Disks large homolog 4", "gene_name": "DLG4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14578-1", "protein_name": "Citron Rho-interacting kinase", "gene_name": "CIT", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14950-1", "protein_name": "Myosin regulatory light chain 12B", "gene_name": "MYL12B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62140-1", "protein_name": "Serine/threonine-protein phosphatase PP1-beta catalytic subunit", "gene_name": "PPP1CB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63000-1", "protein_name": "Ras-related C3 botulinum toxin substrate 1", "gene_name": "RAC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46527-1", "protein_name": "Cyclin-dependent kinase inhibitor 1B", "gene_name": "CDKN1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62745-1", "protein_name": "Rho-related GTP-binding protein RhoB", "gene_name": "RHOB", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60237-1", "protein_name": "Protein phosphatase 1 regulatory subunit 12B", "gene_name": "PPP1R12B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7Z406-1", "protein_name": "Myosin-14", "gene_name": "MYH14", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24844-1", "protein_name": "Myosin regulatory light polypeptide 9", "gene_name": "MYL9", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35580-1", "protein_name": "Myosin-10", "gene_name": "MYH10", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14974-1", "protein_name": "Protein phosphatase 1 regulatory subunit 12A", "gene_name": "PPP1R12A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35749-1", "protein_name": "Myosin-11", "gene_name": "MYH11", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P61586", "url": "https://www.uniprot.org/uniprotkb/P61586" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.12802051", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 19 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway.", "journal": "Genes to cells : devoted to molecular & cellular mechanisms", "date": "2003", "authors": "Oishi I, Suzuki H, Onishi N, Takada R, Kani S, Ohkawara B, Koshida I, Suzuki K, Yamada G, Schwabe GC, Mundlos S, Shibuya H, Takada S, Minami Y", "reference": { "type": "PubMed", "id": "12839624", "url": "https://pubmed.ncbi.nlm.nih.gov/12839624" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P61586-1", "protein_name": "Transforming protein RhoA", "gene_name": "RHOA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y4D1-1", "protein_name": "Disheveled-associated activator of morphogenesis 1", "gene_name": "DAAM1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O96014-1", "protein_name": "Protein Wnt-11", "gene_name": "WNT11", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60353-1", "protein_name": "Frizzled-6", "gene_name": "FZD6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75084-1", "protein_name": "Frizzled-7", "gene_name": "FZD7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UP38-1", "protein_name": "Frizzled-1", "gene_name": "FZD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P07737-1", "protein_name": "Profilin-1", "gene_name": "PFN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14640-1", "protein_name": "Segment polarity protein dishevelled homolog DVL-1", "gene_name": "DVL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14641-1", "protein_name": "Segment polarity protein dishevelled homolog DVL-2", "gene_name": "DVL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63000-1", "protein_name": "Ras-related C3 botulinum toxin substrate 1", "gene_name": "RAC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NPG1-1", "protein_name": "Frizzled-3", "gene_name": "FZD3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56705-1", "protein_name": "Protein Wnt-4", "gene_name": "WNT4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P41221-1", "protein_name": "Protein Wnt-5a", "gene_name": "WNT5A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15153-1", "protein_name": "Ras-related C3 botulinum toxin substrate 2", "gene_name": "RAC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9ULK5-1", "protein_name": "Vang-like protein 2", "gene_name": "VANGL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P34925-1", "protein_name": "Inactive tyrosine-protein kinase RYK", "gene_name": "RYK", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04628-1", "protein_name": "Proto-oncogene Wnt-1", "gene_name": "WNT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P60763-1", "protein_name": "Ras-related C3 botulinum toxin substrate 3", "gene_name": "RAC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H1J7-1", "protein_name": "Protein Wnt-5b", "gene_name": "WNT5B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92997-1", "protein_name": "Segment polarity protein dishevelled homolog DVL-3", "gene_name": "DVL3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q01974-1", "protein_name": "Tyrosine-protein kinase transmembrane receptor ROR2", "gene_name": "ROR2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P61586", "url": "https://www.uniprot.org/uniprotkb/P61586" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.12839624", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 21 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Direct activation of phospholipase C-epsilon by Rho.", "journal": "The Journal of biological chemistry", "date": "2003-10-17", "authors": "Wing Michele R, Snyder Jason T, Sondek John, Harden T Kendall", "reference": { "type": "PubMed", "id": "12900402", "url": "https://pubmed.ncbi.nlm.nih.gov/12900402" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P61586-1", "protein_name": "Transforming protein RhoA", "gene_name": "RHOA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99P84-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1", "gene_name": "Plce1", "tax_name": "Rat" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P61586", "url": "https://www.uniprot.org/uniprotkb/P61586" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.12900402", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, 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I. Identification of the platelet substrate for botulinum C3 ADP-ribosyltransferase as rhoA protein.", "journal": "The Journal of biological chemistry", "date": "1992", "authors": "Nemoto Y, Namba T, Teru-uchi T, Ushikubi F, Morii N, Narumiya S", "reference": { "type": "PubMed", "id": "1328215", "url": "https://pubmed.ncbi.nlm.nih.gov/1328215" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P61586-1", "protein_name": "Transforming protein RhoA", "gene_name": "RHOA", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P61586", "url": "https://www.uniprot.org/uniprotkb/P61586" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.1328215", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { 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Cell Biol.", "date": "2006", "authors": "Wolf Annika, Keil Rene, G\u00f6tzl Oliver, Mun Andrej, Schwarze Katrin, Lederer Marcell, H\u00fcttelmaier Stefan, Hatzfeld Mechthild", "reference": { "type": "PubMed", "id": "17115030", "url": "https://pubmed.ncbi.nlm.nih.gov/17115030" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P61586-1", "protein_name": "Transforming protein RhoA", "gene_name": "RHOA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99569-1", "protein_name": "Plakophilin-4", "gene_name": "PKP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60716-1", "protein_name": "Catenin delta-1", "gene_name": "CTNND1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H8V3-1", "protein_name": "Protein ECT2", "gene_name": "ECT2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P61586", "url": "https://www.uniprot.org/uniprotkb/P61586" } ], "common_name": "Human", 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"date": "2006", "authors": "Witzel S, Zimyanin V, Carreira-Barbosa F, Tada M, Heisenberg CP", "reference": { "type": "PubMed", "id": "17130287", "url": "https://pubmed.ncbi.nlm.nih.gov/17130287" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P61586-1", "protein_name": "Transforming protein RhoA", "gene_name": "RHOA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5S8-1", "protein_name": "NADPH oxidase 1", "gene_name": "NOX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y4D1-1", "protein_name": "Disheveled-associated activator of morphogenesis 1", "gene_name": "DAAM1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O96014-1", "protein_name": "Protein Wnt-11", "gene_name": "WNT11", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60353-1", "protein_name": "Frizzled-6", "gene_name": "FZD6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75084-1", "protein_name": "Frizzled-7", "gene_name": "FZD7", "tax_name": "Human" }, { 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regulation in mice.", "journal": "Developmental biology", "date": "2007", "authors": "Qian D, Jones C, Rzadzinska A, Mark S, Zhang X, Steel KP, Dai X, Chen P", "reference": { "type": "PubMed", "id": "17433286", "url": "https://pubmed.ncbi.nlm.nih.gov/17433286" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P61586-1", "protein_name": "Transforming protein RhoA", "gene_name": "RHOA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y4D1-1", "protein_name": "Disheveled-associated activator of morphogenesis 1", "gene_name": "DAAM1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O96014-1", "protein_name": "Protein Wnt-11", "gene_name": "WNT11", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60353-1", "protein_name": "Frizzled-6", "gene_name": "FZD6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75084-1", "protein_name": "Frizzled-7", "gene_name": "FZD7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UP38-1", "protein_name": 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"protein_name": "Protein Wnt-11", "gene_name": "WNT11", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60353-1", "protein_name": "Frizzled-6", "gene_name": "FZD6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75084-1", "protein_name": "Frizzled-7", "gene_name": "FZD7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UP38-1", "protein_name": "Frizzled-1", "gene_name": "FZD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P07737-1", "protein_name": "Profilin-1", "gene_name": "PFN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14640-1", "protein_name": "Segment polarity protein dishevelled homolog DVL-1", "gene_name": "DVL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14641-1", "protein_name": "Segment polarity protein dishevelled homolog DVL-2", "gene_name": "DVL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63000-1", "protein_name": "Ras-related C3 botulinum toxin substrate 1", "gene_name": "RAC1", "tax_name": "Human" }, { "uniprot_canonical_ac": 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"uniprot_canonical_ac": "Q9H1J7-1", "protein_name": "Protein Wnt-5b", "gene_name": "WNT5B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92997-1", "protein_name": "Segment polarity protein dishevelled homolog DVL-3", "gene_name": "DVL3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q01974-1", "protein_name": "Tyrosine-protein kinase transmembrane receptor ROR2", "gene_name": "ROR2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P61586", "url": "https://www.uniprot.org/uniprotkb/P61586" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.19589360", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 21 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement.", "journal": "Molecular cell", "date": "2009", "authors": "Chen Y, Yang Z, Meng M, Zhao Y, Dong N, Yan H, Liu L, Ding M, Peng HB, Shao F", "reference": { "type": "PubMed", "id": "19782033", "url": "https://pubmed.ncbi.nlm.nih.gov/19782033" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P61586-1", "protein_name": "Transforming protein RhoA", "gene_name": "RHOA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13829-1", "protein_name": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2", "gene_name": "TNFAIP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WZ19-1", "protein_name": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1", "gene_name": "KCTD13", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H3F6-1", "protein_name": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3", "gene_name": "KCTD10", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P61586", "url": "https://www.uniprot.org/uniprotkb/P61586" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 71, "end_pos": 73, "sequence_org": "ILI", "sequence_mut": "AAA", "comment": "Abolishes interaction with CUL3 and induces abnormal actin stress fibers.", "evidence": [ { "database": "UniProtKB", "id": "Q13829", "url": "https://www.uniprot.org/uniprotkb/Q13829" }, { "database": "PubMed", "id": "19782033", "url": "https://pubmed.ncbi.nlm.nih.gov/19782033" } ], "uniprot_canonical_ac": "Q13829-1" }, { "start_pos": 84, "end_pos": 86, "sequence_org": "VLI", "sequence_mut": "AAA", "comment": "Abolishes interaction with CUL3 and induces abnormal actin stress fibers.", "evidence": [ { "database": "UniProtKB", "id": "Q8WZ19", "url": "https://www.uniprot.org/uniprotkb/Q8WZ19" }, { "database": "PubMed", "id": "19782033", "url": "https://pubmed.ncbi.nlm.nih.gov/19782033" } ], "uniprot_canonical_ac": "Q8WZ19-1" } ], "record_id": "pubmed.19782033", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Activated Rac1 GTPase translocates protein phosphatase 5 to the cell membrane and stimulates phosphatase activity in vitro.", "journal": "The Journal of biological chemistry", "date": "2010", "authors": "Chatterjee A, Wang L, Armstrong DL, Rossie S", "reference": { "type": "PubMed", "id": "19948726", "url": "https://pubmed.ncbi.nlm.nih.gov/19948726" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P61586-1", "protein_name": "Transforming protein RhoA", "gene_name": "RHOA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P53041-1", "protein_name": "Serine/threonine-protein phosphatase 5", "gene_name": "PPP5C", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63000-1", "protein_name": "Ras-related C3 botulinum toxin substrate 1", "gene_name": "RAC1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P61586", "url": "https://www.uniprot.org/uniprotkb/P61586" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 14, "end_pos": 14, "sequence_org": "G", "sequence_mut": "V", "comment": "Increased Rho protein signal transduction. Constitutively active.", "evidence": [ { "database": "UniProtKB", "id": "P61586", "url": "https://www.uniprot.org/uniprotkb/P61586" }, { "database": "PubMed", "id": "31570889", "url": "https://pubmed.ncbi.nlm.nih.gov/31570889" }, { "database": "PubMed", "id": "19948726", "url": "https://pubmed.ncbi.nlm.nih.gov/19948726" } ], "uniprot_canonical_ac": "P61586-1" }, { "start_pos": 304, "end_pos": 304, "sequence_org": "H", "sequence_mut": "Q", "comment": "Catalytically inactive; no effect on interaction with CRY2 but increases the stability of the interaction with CSNK1E. No effect on RAF1 phosphorylation.", "evidence": [ { "database": "UniProtKB", "id": "P53041", "url": "https://www.uniprot.org/uniprotkb/P53041" }, { "database": "PubMed", "id": "16790549", "url": "https://pubmed.ncbi.nlm.nih.gov/16790549" }, { "database": "PubMed", "id": "16892053", "url": "https://pubmed.ncbi.nlm.nih.gov/16892053" }, { "database": "PubMed", "id": "19948726", "url": "https://pubmed.ncbi.nlm.nih.gov/19948726" } ], "uniprot_canonical_ac": "P53041-1" }, { "start_pos": 93, "end_pos": 93, "sequence_org": "K", "sequence_mut": "E", "comment": "Decreases interaction with RAC1 and translocation to the membrane in presence of active RAC1.", "evidence": [ { "database": "UniProtKB", "id": "P53041", "url": "https://www.uniprot.org/uniprotkb/P53041" }, { "database": "PubMed", "id": "19948726", "url": "https://pubmed.ncbi.nlm.nih.gov/19948726" } ], "uniprot_canonical_ac": "P53041-1" }, { "start_pos": 17, "end_pos": 17, "sequence_org": "T", "sequence_mut": "N", "comment": "Constitutively inactivated. Abolishes interaction with PARD6 proteins. No effect on NR3C2 transcriptional activity. No interaction with PPP5C. Doesn't activate PPP5C phosphatase activity and translocate PPP5C to the plasma membrane. Doesn't interact with CYRIB.", "evidence": [ { "database": "UniProtKB", "id": "P63000", "url": "https://www.uniprot.org/uniprotkb/P63000" }, { "database": "PubMed", "id": "11260256", "url": "https://pubmed.ncbi.nlm.nih.gov/11260256" }, { "database": "PubMed", "id": "19029984", "url": "https://pubmed.ncbi.nlm.nih.gov/19029984" }, { "database": "PubMed", "id": "30250061", "url": "https://pubmed.ncbi.nlm.nih.gov/30250061" }, { "database": "PubMed", "id": "19948726", "url": "https://pubmed.ncbi.nlm.nih.gov/19948726" } ], "uniprot_canonical_ac": "P63000-1" }, { "start_pos": 30, "end_pos": 30, "sequence_org": "G", "sequence_mut": "V", "comment": "No interaction with PPP5C; when associated with L-61. Translocates to the plasma membrane; also when associated with L-61.", "evidence": [ { "database": "UniProtKB", "id": "P63000", "url": "https://www.uniprot.org/uniprotkb/P63000" }, { "database": "PubMed", "id": "19948726", "url": "https://pubmed.ncbi.nlm.nih.gov/19948726" } ], "uniprot_canonical_ac": "P63000-1" }, { "start_pos": 35, "end_pos": 35, "sequence_org": "T", "sequence_mut": "A", "comment": "Abolishes AMPylation by Vibrio VopS.", "evidence": [ { "database": "UniProtKB", "id": "P63000", "url": "https://www.uniprot.org/uniprotkb/P63000" }, { "database": "PubMed", "id": "19039103", "url": "https://pubmed.ncbi.nlm.nih.gov/19039103" }, { "database": "PubMed", "id": "19948726", "url": "https://pubmed.ncbi.nlm.nih.gov/19948726" } ], "uniprot_canonical_ac": "P63000-1" }, { "start_pos": 35, "end_pos": 35, "sequence_org": "T", "sequence_mut": "S", "comment": "No interaction with PPP5C; when associated with L-61. Translocates to the plasma membrane; also when associated with L-61.", "evidence": [ { "database": "UniProtKB", "id": "P63000", "url": "https://www.uniprot.org/uniprotkb/P63000" }, { "database": "PubMed", "id": "19039103", "url": "https://pubmed.ncbi.nlm.nih.gov/19039103" }, { "database": "PubMed", "id": "19948726", "url": "https://pubmed.ncbi.nlm.nih.gov/19948726" } ], "uniprot_canonical_ac": "P63000-1" }, { "start_pos": 61, "end_pos": 61, "sequence_org": "Q", "sequence_mut": "L", "comment": "Constitutively active. Interacts with PARD6 proteins. Interacts with PPP5C, activates its phosphatase activity and translocates PPP5C to the plasma membrane. No effect on interaction with RAPH1. Interacts with CYRIB. No interaction with PPP5C; when associated with V-30 or S-35. Translocates to the plasma membrane; also when associated with V-30 or S-35.", "evidence": [ { "database": "UniProtKB", "id": "P63000", "url": "https://www.uniprot.org/uniprotkb/P63000" }, { "database": "PubMed", "id": "18499456", "url": "https://pubmed.ncbi.nlm.nih.gov/18499456" }, { "database": "PubMed", "id": "30250061", "url": "https://pubmed.ncbi.nlm.nih.gov/30250061" }, { "database": "PubMed", "id": "10954424", "url": "https://pubmed.ncbi.nlm.nih.gov/10954424" }, { "database": "PubMed", "id": "19948726", "url": "https://pubmed.ncbi.nlm.nih.gov/19948726" }, { "database": "PubMed", "id": "29074776", "url": "https://pubmed.ncbi.nlm.nih.gov/29074776" }, { "database": "PubMed", "id": "38332367", "url": "https://pubmed.ncbi.nlm.nih.gov/38332367" } ], "uniprot_canonical_ac": "P63000-1" } ], "record_id": "pubmed.19948726", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Dishevelled: The hub of Wnt signaling.", "journal": "Cellular signalling", "date": "2010", "authors": "Gao C, Chen YG", "reference": { "type": "PubMed", "id": "20006983", "url": "https://pubmed.ncbi.nlm.nih.gov/20006983" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P61586-1", "protein_name": "Transforming protein RhoA", "gene_name": "RHOA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5S8-1", "protein_name": "NADPH oxidase 1", "gene_name": "NOX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y4D1-1", "protein_name": "Disheveled-associated activator of morphogenesis 1", "gene_name": "DAAM1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O96014-1", "protein_name": "Protein Wnt-11", "gene_name": "WNT11", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60353-1", "protein_name": "Frizzled-6", "gene_name": "FZD6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75084-1", "protein_name": "Frizzled-7", "gene_name": "FZD7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UP38-1", "protein_name": "Frizzled-1", "gene_name": "FZD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P07737-1", "protein_name": "Profilin-1", "gene_name": "PFN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14640-1", "protein_name": "Segment polarity protein dishevelled homolog DVL-1", "gene_name": "DVL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14641-1", "protein_name": "Segment polarity protein dishevelled homolog DVL-2", "gene_name": "DVL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63000-1", "protein_name": "Ras-related C3 botulinum toxin substrate 1", "gene_name": "RAC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P13498-1", "protein_name": "Cytochrome b-245 light chain", "gene_name": "CYBA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFA2-1", "protein_name": "NADPH oxidase organizer 1", "gene_name": "NOXO1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NPG1-1", "protein_name": "Frizzled-3", "gene_name": "FZD3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56705-1", "protein_name": "Protein Wnt-4", "gene_name": "WNT4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P41221-1", "protein_name": "Protein Wnt-5a", "gene_name": "WNT5A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P45983-1", "protein_name": "Mitogen-activated protein kinase 8", "gene_name": "MAPK8", "tax_name": "Human" }, { 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Treat.", "date": "2011", "authors": "Cao Xi-Xi, Xu Jing-Da, Xu Jia-Wen, Liu Xiao-Li, Cheng Yuan-Yuan, Li Qing-Quan, Xu Zu-De, Liu Xiu-Ping", "reference": { "type": "PubMed", "id": "20499158", "url": "https://pubmed.ncbi.nlm.nih.gov/20499158" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P61586-1", "protein_name": "Transforming protein RhoA", "gene_name": "RHOA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63244-1", "protein_name": "Small ribosomal subunit protein RACK1", "gene_name": "RACK1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P61586", "url": "https://www.uniprot.org/uniprotkb/P61586" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.20499158", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Splice variants of SmgGDS control small GTPase prenylation and membrane localization.", "journal": "J. Biol. Chem.", "date": "2010", "authors": "Berg Tracy J, Gastonguay Adam J, Lorimer Ellen L, Kuhnmuench John R, Li Rongshan, Fields Alan P, Williams Carol L", "reference": { "type": "PubMed", "id": "20709748", "url": "https://pubmed.ncbi.nlm.nih.gov/20709748" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P61586-1", "protein_name": "Transforming protein RhoA", "gene_name": "RHOA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62834-1", "protein_name": "Ras-related protein Rap-1A", "gene_name": "RAP1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63000-1", "protein_name": "Ras-related C3 botulinum toxin substrate 1", "gene_name": "RAC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01116-1", "protein_name": "GTPase KRas", "gene_name": "KRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P52306-1", "protein_name": "Rap1 GTPase-GDP dissociation stimulator 1", "gene_name": "RAP1GDS1", "tax_name": "Human" } ], "species": [ { "name": "Homo 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[] } ] }, { "title": "Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity.", "journal": "Cytoskeleton (Hoboken, N.J.)", "date": "2010", "authors": "Amano M, Nakayama M, Kaibuchi K", "reference": { "type": "PubMed", "id": "20803696", "url": "https://pubmed.ncbi.nlm.nih.gov/20803696" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P61586-1", "protein_name": "Transforming protein RhoA", "gene_name": "RHOA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y4D1-1", "protein_name": "Disheveled-associated activator of morphogenesis 1", "gene_name": "DAAM1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O96014-1", "protein_name": "Protein Wnt-11", "gene_name": "WNT11", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13464-1", "protein_name": "Rho-associated protein kinase 1", "gene_name": "ROCK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75116-1", "protein_name": "Rho-associated protein kinase 2", "gene_name": "ROCK2", 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