[ { "title": "Expression and pharmacology of human GABAA receptors containing gamma 3 subunits.", "journal": "European journal of pharmacology", "date": "1995", "authors": "Hadingham KL, Wafford KA, Thompson SA, Palmer KJ, Whiting PJ", "reference": { "type": "PubMed", "id": "8719414", "url": "https://pubmed.ncbi.nlm.nih.gov/8719414" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43307-1", "protein_name": "Rho guanine nucleotide exchange factor 9", "gene_name": "ARHGEF9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y639-2", "protein_name": "Neuroplastin", "gene_name": "NPTN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P28472-1", "protein_name": "Gamma-aminobutyric acid receptor subunit beta-3", "gene_name": "GABRB3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14867-1", "protein_name": "Gamma-aminobutyric acid receptor subunit alpha-1", "gene_name": "GABRA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18505-1", "protein_name": "Gamma-aminobutyric acid receptor subunit beta-1", "gene_name": "GABRB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P47870-2", "protein_name": "Gamma-aminobutyric acid receptor subunit beta-2", "gene_name": "GABRB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16445-1", "protein_name": "Gamma-aminobutyric acid receptor subunit alpha-6", "gene_name": "GABRA6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99928-1", "protein_name": "Gamma-aminobutyric acid receptor subunit gamma-3", "gene_name": "GABRG3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P28476-1", "protein_name": "Gamma-aminobutyric acid receptor subunit rho-2", "gene_name": "GABRR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P31644-1", "protein_name": "Gamma-aminobutyric acid receptor subunit alpha-5", "gene_name": "GABRA5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P47869-1", "protein_name": "Gamma-aminobutyric acid receptor subunit alpha-2", "gene_name": "GABRA2", 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characterization of the human GABAA receptor alpha 4 subunit: identification of a unique diazepam-insensitive binding site.", "journal": "European journal of pharmacology", "date": "1995", "authors": "Yang W, Drewe JA, Lan NC", "reference": { "type": "PubMed", "id": "8719416", "url": "https://pubmed.ncbi.nlm.nih.gov/8719416" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43307-1", "protein_name": "Rho guanine nucleotide exchange factor 9", "gene_name": "ARHGEF9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y639-2", "protein_name": "Neuroplastin", "gene_name": "NPTN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P28472-1", "protein_name": "Gamma-aminobutyric acid receptor subunit beta-3", "gene_name": "GABRB3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14867-1", "protein_name": "Gamma-aminobutyric acid receptor subunit alpha-1", "gene_name": "GABRA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18505-1", "protein_name": 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human genetics", "date": "2003", "authors": "Verhoeven K, De Jonghe P, Van de Putte T, Nelis E, Zwijsen A, Verpoorten N, De Vriendt E, Jacobs A, Van Gerwen V, Francis A, Ceuterick C, Huylebroeck D, Timmerman V", "reference": { "type": "PubMed", "id": "14508709", "url": "https://pubmed.ncbi.nlm.nih.gov/14508709" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15013-1", "protein_name": "Rho guanine nucleotide exchange factor 10", "gene_name": "ARHGEF10", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8C033-1", "protein_name": "Rho guanine nucleotide exchange factor 10", "gene_name": "Arhgef10", "tax_name": "Mouse" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15013", "url": "https://www.uniprot.org/uniprotkb/O15013" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.14508709", "abstract": "", "glycosylation": [], 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"Design and solution structure of a well-folded stack of two beta-hairpins based on the amino-terminal fragment of human granulin A.", "journal": "Biochemistry", "date": "2000", "authors": "Tolkatchev D, Ng A, Vranken W, Ni F", "reference": { "type": "PubMed", "id": "10715107", "url": "https://pubmed.ncbi.nlm.nih.gov/10715107" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P28799-1", "protein_name": "Progranulin", "gene_name": "GRN", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P28799", "url": "https://www.uniprot.org/uniprotkb/P28799" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10715107", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 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Setchell KDR, Sun Y, Overkleeft HS, Chan GL, Liu CJ", "reference": { "type": "PubMed", "id": "27789271", "url": "https://pubmed.ncbi.nlm.nih.gov/27789271" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P28799-1", "protein_name": "Progranulin", "gene_name": "GRN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P28798-1", "protein_name": "Progranulin", "gene_name": "Grn", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "P04062-1", "protein_name": "Lysosomal acid glucosylceramidase", "gene_name": "GBA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P17439-1", "protein_name": "Lysosomal acid glucosylceramidase", "gene_name": "Gba1", "tax_name": "Mouse" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P28799", "url": "https://www.uniprot.org/uniprotkb/P28799" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.27789271", 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Geidy, Beach Thomas G, Yamanouchi Keitaro, Hasegawa Masato, Nishihara Masugi", "reference": { "type": "PubMed", "id": "28073925", "url": "https://pubmed.ncbi.nlm.nih.gov/28073925" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P28799-1", "protein_name": "Progranulin", "gene_name": "GRN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P28798-1", "protein_name": "Progranulin", "gene_name": "Grn", "tax_name": "Mouse" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P28799", "url": "https://www.uniprot.org/uniprotkb/P28799" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.28073925", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ 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"o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.", "journal": "Human molecular genetics", "date": "2017-08-01", "authors": "Beel Sander, Moisse Matthieu, Damme Markus, De Muynck Louis, Robberecht Wim, Van Den Bosch Ludo, Saftig Paul, Van Damme Philip", "reference": { "type": "PubMed", "id": "28453791", "url": "https://pubmed.ncbi.nlm.nih.gov/28453791" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": 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}, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations.", "journal": "Nature communications", "date": "2017", "authors": "Zhou X, Sun L, Bracko O, Choi JW, Jia Y, Nana AL, Brady OA, Hernandez JCC, Nishimura N, Seeley WW, Hu F", "reference": { "type": "PubMed", "id": "28541286", "url": "https://pubmed.ncbi.nlm.nih.gov/28541286" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P28799-1", "protein_name": "Progranulin", "gene_name": "GRN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P28798-1", "protein_name": "Progranulin", "gene_name": "Grn", 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"count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The lysosomal protein cathepsin L is a progranulin protease.", "journal": "Molecular neurodegeneration", "date": "2017", "authors": "Lee CW, Stankowski JN, Chew J, Cook CN, Lam YW, Almeida S, Carlomagno Y, Lau KF, Prudencio M, Gao FB, Bogyo M, Dickson DW, Petrucelli L", "reference": { "type": "PubMed", "id": "28743268", "url": "https://pubmed.ncbi.nlm.nih.gov/28743268" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P28799-1", "protein_name": "Progranulin", "gene_name": "GRN", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P28799", "url": "https://www.uniprot.org/uniprotkb/P28799" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.28743268", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], 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Cancer", "date": "1993", "authors": "Kardana A, Bagshawe K D, Coles B, Read D, Taylor M", "reference": { "type": "PubMed", "id": "8471426", "url": "https://pubmed.ncbi.nlm.nih.gov/8471426" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P28799-1", "protein_name": "Progranulin", "gene_name": "GRN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P10153-1", "protein_name": "Non-secretory ribonuclease", "gene_name": "RNASE2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P28799", "url": "https://www.uniprot.org/uniprotkb/P28799" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.8471426", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], 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Immunol.", "date": "2003", "authors": "Fan Z, Beresford PJ, Zhang D, Xu Z, Novina CD, Yoshida A, Pommier Y, Lieberman J", "reference": { "type": "PubMed", "id": "12524539", "url": "https://pubmed.ncbi.nlm.nih.gov/12524539" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P39687-1", "protein_name": "Acidic leucine-rich nuclear phosphoprotein 32 family member A", "gene_name": "ANP32A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27695-1", "protein_name": "DNA repair nuclease/redox regulator APEX1", "gene_name": "APEX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12544-1", "protein_name": "Granzyme A", "gene_name": "GZMA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q01105-1", "protein_name": "Protein SET", "gene_name": "SET", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P39687", "url": "https://www.uniprot.org/uniprotkb/P39687" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 210, "end_pos": 210, "sequence_org": "D", "sequence_mut": "A", "comment": "Abolishes the AP endodeoxyribonuclease activity. 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acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death.", "journal": "Mol. Cell", "date": "2006", "authors": "Chowdhury D, Beresford PJ, Zhu P, Zhang D, Sung JS, Demple B, Perrino FW, Lieberman J", "reference": { "type": "PubMed", "id": "16818237", "url": "https://pubmed.ncbi.nlm.nih.gov/16818237" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P39687-1", "protein_name": "Acidic leucine-rich nuclear phosphoprotein 32 family member A", "gene_name": "ANP32A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NSU2-3", "protein_name": "Three-prime repair exonuclease 1", "gene_name": "TREX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15531-1", "protein_name": "Nucleoside diphosphate kinase A", "gene_name": "NME1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12544-1", "protein_name": "Granzyme A", "gene_name": "GZMA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q01105-1", "protein_name": "Protein SET", "gene_name": "SET", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, 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Shujun, Ji Ping, Huang Weiren, Zhao Guoping, Cao Zhiwei, Shen Haibo, Wang Ying", "reference": { "type": "PubMed", "id": "33329543", "url": "https://pubmed.ncbi.nlm.nih.gov/33329543" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P39687-1", "protein_name": "Acidic leucine-rich nuclear phosphoprotein 32 family member A", "gene_name": "ANP32A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61586-1", "protein_name": "Transforming protein RhoA", "gene_name": "RHOA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16531-1", "protein_name": "DNA damage-binding protein 1", "gene_name": "DDB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P60953-2", "protein_name": "Cell division control protein 42 homolog", "gene_name": "CDC42", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IZ83-1", "protein_name": "Aldehyde dehydrogenase family 16 member A1", "gene_name": "ALDH16A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08581-1", 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"2023-01-20", "authors": "Ding H, Li X, Zhou L, Cui Z, Meng H, Wang J", "reference": { "type": "PubMed", "id": "36856210", "url": "https://pubmed.ncbi.nlm.nih.gov/36856210" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P39687-1", "protein_name": "Acidic leucine-rich nuclear phosphoprotein 32 family member A", "gene_name": "ANP32A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P39687", "url": "https://www.uniprot.org/uniprotkb/P39687" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.36856210", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { 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Hoppe-Seyler", "date": "1994", "authors": "Vaesen M, Barnikol-Watanabe S, Gotz H, Awni LA, Cole T, Zimmermann B, Kratzin HD, Hilschmann N", "reference": { "type": "PubMed", "id": "8192856", "url": "https://pubmed.ncbi.nlm.nih.gov/8192856" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P39687-1", "protein_name": "Acidic leucine-rich nuclear phosphoprotein 32 family member A", "gene_name": "ANP32A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q01105-1", "protein_name": "Protein SET", "gene_name": "SET", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P39687", "url": "https://www.uniprot.org/uniprotkb/P39687" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.8192856", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { 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