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        "journal": "Biochemistry and cell biology = Biochimie et biologie cellulaire",
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    {
        "title": "E3 ubiquitin ligase ANKIB1 attenuates antiviral immune responses by promoting K48-linked polyubiquitination of MAVS.",
        "journal": "Cell reports",
        "date": "2024-09-24",
        "authors": "Liu Wei, Yuan Cui, Fu Buwen, Xie Jiufeng, Li Wenqing, Zhang Guozhi, Ma Zhenling, Jiao Pengtao",
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            "type": "PubMed",
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                "uniprot_canonical_ac": "Q9P2G1-1",
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                        "field": "n_linked_glycans",
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                ],
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        ]
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    {
        "title": "Guanosine diphosphate-mannose:GlcNAc2-PP-dolichol mannosyltransferase deficiency (congenital disorders of glycosylation type Ik): five new patients and seven novel mutations.",
        "journal": "Journal of medical genetics",
        "date": "2010",
        "authors": "Dupre T, Vuillaumier-Barrot S, Chantret I, Sadou Yaye H, Le Bizec C, Afenjar A, Altuzarra C, Barnerias C, Burglen L, de Lonlay P, Feillet F, Napuri S, Seta N, Moore SE",
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        ],
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                    {
                        "id": "rs387906926",
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                    {
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                    {
                        "id": "rs387906926",
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                        "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs387906926"
                    }
                ],
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                "start_pos": 145,
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                "subjects_tested": "1704",
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                "sequence_org": "G",
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                "comment": "Somatic mutation passed 1 filters: protein-of-interest(glycogene, glycosyltransferase).",
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                "site_lbl": "G145",
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                    {
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                                "url": "https://disease-ontology.org/term/DOID:363",
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                                "description": ""
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                                "id": "DOID:363",
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                                "description": ""
                            },
                            {
                                "id": "DOID:363",
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                                "url": "https://disease-ontology.org/term/DOID:363",
                                "name": "malignant neoplasm of uterus",
                                "description": ""
                            },
                            {
                                "id": "DOID:363",
                                "resource": "Disease Ontology",
                                "url": "https://disease-ontology.org/term/DOID:363",
                                "name": "malignant uterine tumor",
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                            },
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                            }
                        ],
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                            "DOID:5166",
                            "DOID:2021",
                            "DOID:4114"
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                    },
                    {
                        "disease_id": "DOID:0080563",
                        "recommended_name": {
                            "id": "DOID:0080563",
                            "resource": "Disease Ontology",
                            "url": "https://disease-ontology.org/term/DOID:0080563",
                            "name": "congenital disorder of glycosylation Ik",
                            "description": "A congenital disorder of glycosylation I that is characterized by severe developmental and psychomotor delay, muscular hypotonia, intractable early-onset seizures, and microcephaly and has_material_basis_in homozygous or compound heterozygous mutation in the gene encoding beta-1,4-mannosyltransferase on chromosome 16p13."
                        },
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                            {
                                "id": "DOID:0080563",
                                "resource": "Disease Ontology",
                                "url": "https://disease-ontology.org/term/DOID:0080563",
                                "name": "congenital disorder of glycosylation 1k",
                                "description": ""
                            },
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                                "id": "MONDO:0012052",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012052",
                                "name": "ALG1-congenital disorder of glycosylation",
                                "description": "A severe form of congenital disorders of N-linked glycosylation characterized by severe developmental and psychomotor delay, muscular hypotonia, intractable early-onset seizures, and microcephaly. Additional features include altered blood coagulation with a high probability of hemorrhages or thromboses, nephrotic syndrome, ascites, hepatomegaly, cardiomyopathy, ocular manifestations (strabismus, nystagmus), and immunodeficiency. The disease is caused by loss-of-function mutations in the gene ALG1 (16p13.3)."
                            },
                            {
                                "id": "MONDO:0012052",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012052",
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                                "description": ""
                            },
                            {
                                "id": "MONDO:0012052",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012052",
                                "name": "ALG1-congenital disorder of glycosylation",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0012052",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012052",
                                "name": "CDG syndrome type Ik",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0012052",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012052",
                                "name": "CDG-Ik",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0012052",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012052",
                                "name": "CDG1K",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0012052",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012052",
                                "name": "carbohydrate deficient glycoprotein syndrome type Ik",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0012052",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012052",
                                "name": "congenital disorder of glycosylation type 1k",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0012052",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012052",
                                "name": "congenital disorder of glycosylation type Ik",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0012052",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012052",
                                "name": "mannosyltransferase 1 deficiency",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0012052",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012052",
                                "name": "ALG1-CDG (CDG-Ik)",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0012052",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012052",
                                "name": "CDG 1K",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0012052",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012052",
                                "name": "congenital disorder of glycosylation, type Ik",
                                "description": ""
                            },
                            {
                                "id": "MIM:608540",
                                "resource": "MIM",
                                "url": "https://www.omim.org/entry/608540",
                                "name": "Congenital disorder of glycosylation 1K",
                                "description": "Congenital disorder of glycosylation 1K"
                            }
                        ],
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                                "id": "0080563",
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                            },
                            {
                                "id": "0080563",
                                "database": "AGR",
                                "url": "https://www.alliancegenome.org/disease/DOID:0080563"
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                        ]
                    }
                ],
                "keywords": [
                    "biomuta",
                    "somatic",
                    "cancer",
                    "disease",
                    "ebi"
                ],
                "filter_code": "000000010000000000000.00000000000000.000000000001000000.00001.01.000.000",
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            {
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                    {
                        "id": "rs151173406",
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                        "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs151173406"
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                    {
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                    {
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                        "id": "20679665",
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                        "url": "https://pubmed.ncbi.nlm.nih.gov/20679665"
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                ],
                "glycoeffect": [],
                "start_pos": 276,
                "end_pos": 276,
                "sequence_org": "R",
                "sequence_mut": "W",
                "comment": "Germline mutation passed 1 filters: glycogene of type=glycogene, glycosyltransferase.",
                "chr_id": "16",
                "chr_pos": "5078842",
                "ref_nt": "T",
                "alt_nt": "null",
                "minor_allelic_frequency": "",
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        "title": "ALG1-CDG: Clinical and Molecular Characterization of 39 Unreported Patients.",
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                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                                "name": "malignant neoplasm of the esophagus",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                                "name": "malignant neoplasm of the oesophagus",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                                "name": "malignant oesophagus neoplasm",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                                "name": "malignant oesophagus tumour",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                                "name": "malignant tumor of esophagus",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                                "name": "malignant tumor of the esophagus",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                                "name": "malignant tumour of oesophagus",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                                "name": "malignant tumour of the oesophagus",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                                "name": "oesophagus cancer",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                                "name": "Ca lower third esophagus",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                                "name": "Ca lower third oesophagus",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                                "name": "Ca middle third esophagus",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                                "name": "Ca middle third oesophagus",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                                "name": "malignant neoplasm of distal third of esophagus",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                                "name": "malignant neoplasm of distal third of oesophagus",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                                "name": "malignant neoplasm of lower third of esophagus",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                                "name": "malignant neoplasm of lower third of oesophagus",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                                "name": "malignant neoplasm of middle third of esophagus",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                                "name": "malignant neoplasm of middle third of oesophagus",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                                "name": "malignant neoplasm of proximal third of esophagus",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                                "name": "malignant neoplasm of proximal third of oesophagus",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                                "name": "malignant neoplasm of upper third esophagus",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                                "name": "malignant neoplasm of upper third oesophagus",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                                "name": "malignant tumor of abdominal esophagus",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                                "name": "malignant tumor of distal third of esophagus",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                                "name": "malignant tumor of proximal third of esophagus",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                                "name": "malignant tumor of the middle third of the esophagus",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                                "name": "malignant tumour of abdominal oesophagus",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                                "name": "malignant tumour of distal third of oesophagus",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                                "name": "malignant tumour of proximal third of oesophagus",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0007576",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                                "name": "malignant tumour of the middle third of the oesophagus",
                                "description": ""
                            },
                            {
                                "id": "MIM:133239",
                                "resource": "MIM",
                                "url": "https://www.omim.org/entry/133239",
                                "name": "Esophageal cancer",
                                "description": "Esophageal cancer"
                            }
                        ],
                        "unlinked_id_list": [],
                        "evidence": [
                            {
                                "id": "5041",
                                "database": "AGR",
                                "url": "https://www.alliancegenome.org/disease/DOID:5041"
                            }
                        ]
                    },
                    {
                        "disease_id": "DOID:0080563",
                        "recommended_name": {
                            "id": "DOID:0080563",
                            "resource": "Disease Ontology",
                            "url": "https://disease-ontology.org/term/DOID:0080563",
                            "name": "congenital disorder of glycosylation Ik",
                            "description": "A congenital disorder of glycosylation I that is characterized by severe developmental and psychomotor delay, muscular hypotonia, intractable early-onset seizures, and microcephaly and has_material_basis_in homozygous or compound heterozygous mutation in the gene encoding beta-1,4-mannosyltransferase on chromosome 16p13."
                        },
                        "synonyms": [
                            {
                                "id": "DOID:0080563",
                                "resource": "Disease Ontology",
                                "url": "https://disease-ontology.org/term/DOID:0080563",
                                "name": "congenital disorder of glycosylation 1k",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0012052",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012052",
                                "name": "ALG1-congenital disorder of glycosylation",
                                "description": "A severe form of congenital disorders of N-linked glycosylation characterized by severe developmental and psychomotor delay, muscular hypotonia, intractable early-onset seizures, and microcephaly. Additional features include altered blood coagulation with a high probability of hemorrhages or thromboses, nephrotic syndrome, ascites, hepatomegaly, cardiomyopathy, ocular manifestations (strabismus, nystagmus), and immunodeficiency. The disease is caused by loss-of-function mutations in the gene ALG1 (16p13.3)."
                            },
                            {
                                "id": "MONDO:0012052",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012052",
                                "name": "ALG1-CDG",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0012052",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012052",
                                "name": "ALG1-congenital disorder of glycosylation",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0012052",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012052",
                                "name": "CDG syndrome type Ik",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0012052",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012052",
                                "name": "CDG-Ik",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0012052",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012052",
                                "name": "CDG1K",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0012052",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012052",
                                "name": "carbohydrate deficient glycoprotein syndrome type Ik",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0012052",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012052",
                                "name": "congenital disorder of glycosylation type 1k",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0012052",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012052",
                                "name": "congenital disorder of glycosylation type Ik",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0012052",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012052",
                                "name": "mannosyltransferase 1 deficiency",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0012052",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012052",
                                "name": "ALG1-CDG (CDG-Ik)",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0012052",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012052",
                                "name": "CDG 1K",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0012052",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0012052",
                                "name": "congenital disorder of glycosylation, type Ik",
                                "description": ""
                            },
                            {
                                "id": "MIM:608540",
                                "resource": "MIM",
                                "url": "https://www.omim.org/entry/608540",
                                "name": "Congenital disorder of glycosylation 1K",
                                "description": "Congenital disorder of glycosylation 1K"
                            }
                        ],
                        "unlinked_id_list": [],
                        "evidence": [
                            {
                                "id": "0080563",
                                "database": "AGR",
                                "url": "https://www.alliancegenome.org/disease/DOID:0080563"
                            },
                            {
                                "id": "0080563",
                                "database": "AGR",
                                "url": "https://www.alliancegenome.org/disease/DOID:0080563"
                            }
                        ]
                    },
                    {
                        "disease_id": "DOID:0080559",
                        "recommended_name": {
                            "id": "DOID:0080559",
                            "resource": "Disease Ontology",
                            "url": "https://disease-ontology.org/term/DOID:0080559",
                            "name": "congenital disorder of glycosylation Ig",
                            "description": "A congenital disorder of glycosylation I that is characterized by facial dysmorphism (prominent forehead, large ears, thin upper lip), generalized hypotonia, feeding difficulties, moderate to severe developmental delay, progressive microcephaly, frequent upper respiratory tract infections due to impaired immunity with decreased immunoglobulin levels, and decreased coagulation factors and has_material_basis_in homozygous or compound heterozygous mutation in the gene encoding dolichyl-P-mannose:Man-7-GlcNAc-2-PP-dolichyl-alpha-6-mannosyltransferase on chromosome 22q13."
                        },
                        "synonyms": [
                            {
                                "id": "DOID:0080559",
                                "resource": "Disease Ontology",
                                "url": "https://disease-ontology.org/term/DOID:0080559",
                                "name": "ALG12-congenital disorder of glycosylation",
                                "description": ""
                            },
                            {
                                "id": "DOID:0080559",
                                "resource": "Disease Ontology",
                                "url": "https://disease-ontology.org/term/DOID:0080559",
                                "name": "congenital disorder of glycosylation 1g",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0011783",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0011783",
                                "name": "ALG12-congenital disorder of glycosylation",
                                "description": "A form of congenital disorders of N-linked glycosylation characterized by facial dysmorphism (prominent forehead, large ears, thin upper lip), generalized hypotonia, feeding difficulties, moderate to severe developmental delay, progressive microcephaly, frequent upper respiratory tract infections due to impaired immunity with decreased immunoglobulin levels, and decreased coagulation factors. Additional features include hypogonadism with or without hypospadias in males, skeletal anomalies, seizures and cardiac anomalies in some cases. The disease is caused by loss of function mutations of the gene ALG12 (22q13.33)."
                            },
                            {
                                "id": "MONDO:0011783",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0011783",
                                "name": "ALG12-CDG",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0011783",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0011783",
                                "name": "ALG12-congenital disorder of glycosylation",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0011783",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0011783",
                                "name": "CDG syndrome type Ig",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0011783",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0011783",
                                "name": "CDG-Ig",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0011783",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0011783",
                                "name": "CDG1G",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0011783",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0011783",
                                "name": "CDGIg",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0011783",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0011783",
                                "name": "carbohydrate deficient glycoprotein syndrome type Ig",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0011783",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0011783",
                                "name": "congenital disorder of glycosylation type 1g",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0011783",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0011783",
                                "name": "congenital disorder of glycosylation type Ig",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0011783",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0011783",
                                "name": "mannosyltransferase 8 deficiency",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0011783",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0011783",
                                "name": "ALG12-CDG (CDG-Ig)",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0011783",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0011783",
                                "name": "CDG 1G",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0011783",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0011783",
                                "name": "congenital disorder of glycosylation, type Ig",
                                "description": ""
                            },
                            {
                                "id": "MIM:607143",
                                "resource": "MIM",
                                "url": "https://www.omim.org/entry/607143",
                                "name": "Congenital disorder of glycosylation 1G",
                                "description": "Congenital disorder of glycosylation 1G"
                            }
                        ],
                        "unlinked_id_list": [],
                        "evidence": [
                            {
                                "id": "0011783",
                                "database": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0011783"
                            },
                            {
                                "id": "607143",
                                "database": "MIM",
                                "url": "https://www.omim.org/entry/607143"
                            },
                            {
                                "id": "ALG12",
                                "database": "Genomics England",
                                "url": "https://panelapp.genomicsengland.co.uk/panels/25/gene/ALG12/#!details"
                            },
                            {
                                "id": "79087",
                                "database": "GlyCosmos",
                                "url": "https://glycosmos.org/glycogenes/show/79087#disease"
                            },
                            {
                                "id": "0080559",
                                "database": "AGR",
                                "url": "https://www.alliancegenome.org/disease/DOID:0080559"
                            }
                        ]
                    },
                    {
                        "disease_id": "DOID:0080390",
                        "recommended_name": {
                            "id": "DOID:0080390",
                            "resource": "Disease Ontology",
                            "url": "https://disease-ontology.org/term/DOID:0080390",
                            "name": "nephrotic syndrome type 1",
                            "description": "A familial nephrotic syndrome characterized by prenatal onset of massive proteinuria followed by steroid resistant renal disease that has_material_basis_in homozygous or compound heterozygous mutation in the NPHS1 gene on chromosome 19q13."
                        },
                        "synonyms": [
                            {
                                "id": "DOID:0080390",
                                "resource": "Disease Ontology",
                                "url": "https://disease-ontology.org/term/DOID:0080390",
                                "name": "Finnish congenital nephrosis",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0009732",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0009732",
                                "name": "congenital nephrotic syndrome, Finnish type",
                                "description": "Congenital nephrotic syndrome, Finnish type is characterized by protein loss beginning during fetal life."
                            },
                            {
                                "id": "MONDO:0009732",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0009732",
                                "name": "Finnish congenital nephrosis",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0009732",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0009732",
                                "name": "congenital nephrotic syndrome - Finnish type",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0009732",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0009732",
                                "name": "congenital nephrotic syndrome, Finnish type",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0009732",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0009732",
                                "name": "nephrotic syndrome - NPHS1 associated",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0009732",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0009732",
                                "name": "CnF",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0009732",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0009732",
                                "name": "NPHS1",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0009732",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0009732",
                                "name": "congenital nephrotic syndrome 1",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0009732",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0009732",
                                "name": "congenital nephrotic syndrome Finnish type",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0009732",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0009732",
                                "name": "nephrosis 1, congenital, Finnish type",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0009732",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0009732",
                                "name": "nephrosis, congenital",
                                "description": ""
                            },
                            {
                                "id": "MONDO:0009732",
                                "resource": "MONDO",
                                "url": "https://monarchinitiative.org/disease/MONDO:0009732",
                                "name": "nephrotic syndrome, type 1",
                                "description": ""
                            },
                            {
                                "id": "MIM:256300",
                                "resource": "MIM",
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        "title": "A covalent protein-DNA 5'-product adduct is generated following AP lyase activity of human ALKBH1 (AlkB homologue 1).",
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    {
        "title": "Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid.",
        "journal": "The EMBO journal",
        "date": "2000-06-01",
        "authors": "Egea P F, Mitschler A, Rochel N, Ruff M, Chambon P, Moras D",
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            "type": "PubMed",
            "id": "10835357",
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                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "Q92793-1",
                "protein_name": "CREB-binding protein",
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                "tax_name": "Human"
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                "uniprot_canonical_ac": "Q15596-1",
                "protein_name": "Nuclear receptor coactivator 2",
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                "tax_name": "Human"
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                "tax_name": "Human"
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                "protein_name": "Nuclear receptor corepressor 2",
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                "tax_name": "Human"
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                "uniprot_canonical_ac": "Q8NEZ4-1",
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                "tax_name": "Human"
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                "uniprot_canonical_ac": "Q15291-1",
                "protein_name": "Retinoblastoma-binding protein 5",
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                "protein_name": "PAX-interacting protein 1",
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                "tax_name": "Human"
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        "title": "Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors.",
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    {
        "title": "Discrete roles for peroxisome proliferator-activated receptor gamma and retinoid X receptor in recruiting nuclear receptor coactivators.",
        "journal": "Molecular and cellular biology",
        "date": "2000",
        "authors": "Yang W, Rachez C, Freedman LP",
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    {
        "title": "9-cis retinoic acid is a high affinity ligand for the retinoid X receptor.",
        "journal": "Cell",
        "date": "1992-01-24",
        "authors": "Heyman R A, Mangelsdorf D J, Dyck J A, Stein R B, Eichele G, Evans R M, Thaller C",
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            "type": "PubMed",
            "id": "1310260",
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                "uniprot_canonical_ac": "Q92793-1",
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                "uniprot_canonical_ac": "Q9Y618-1",
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                "uniprot_canonical_ac": "Q8NEZ4-1",
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                "protein_name": "Angiopoietin-related protein 4",
                "gene_name": "ANGPTL4",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9Y618-1",
                "protein_name": "Nuclear receptor corepressor 2",
                "gene_name": "NCOR2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8NEZ4-1",
                "protein_name": "Histone-lysine N-methyltransferase 2C",
                "gene_name": "KMT2C",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q15291-1",
                "protein_name": "Retinoblastoma-binding protein 5",
                "gene_name": "RBBP5",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q6ZW49-6",
                "protein_name": "PAX-interacting protein 1",
                "gene_name": "PAXIP1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9NYP7-1",
                "protein_name": "Very long chain fatty acid elongase 5",
                "gene_name": "ELOVL5",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q15648-1",
                "protein_name": "Mediator of RNA polymerase II transcription subunit 1",
                "gene_name": "MED1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P19793-1",
                "protein_name": "Retinoic acid receptor RXR-alpha",
                "gene_name": "RXRA",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q16654-1",
                "protein_name": "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial",
                "gene_name": "PDK4",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O60907-1",
                "protein_name": "F-box-like/WD repeat-containing protein TBL1X",
                "gene_name": "TBL1X",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P84243-1",
                "protein_name": "Histone H3.3",
                "gene_name": "H3-3A; H3-3B",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9BZK7-1",
                "protein_name": "F-box-like/WD repeat-containing protein TBL1XR1",
                "gene_name": "TBL1XR1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9Y6Q9-1",
                "protein_name": "Nuclear receptor coactivator 3",
                "gene_name": "NCOA3",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q13227-1",
                "protein_name": "G protein pathway suppressor 2",
                "gene_name": "GPS2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P49715-1",
                "protein_name": "CCAAT/enhancer-binding protein alpha",
                "gene_name": "CEBPA",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P16671-1",
                "protein_name": "Platelet glycoprotein 4",
                "gene_name": "CD36",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q05469-1",
                "protein_name": "Hormone-sensitive lipase",
                "gene_name": "LIPE",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q14693-1",
                "protein_name": "Phosphatidate phosphatase LPIN1",
                "gene_name": "LPIN1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O75448-1",
                "protein_name": "Mediator of RNA polymerase II transcription subunit 24",
                "gene_name": "MED24",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9Y2X0-1",
                "protein_name": "Mediator of RNA polymerase II transcription subunit 16",
                "gene_name": "MED16",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9NVC6-1",
                "protein_name": "Mediator of RNA polymerase II transcription subunit 17",
                "gene_name": "MED17",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9UHV7-1",
                "protein_name": "Mediator of RNA polymerase II transcription subunit 13",
                "gene_name": "MED13",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9H944-1",
                "protein_name": "Mediator of RNA polymerase II transcription subunit 20",
                "gene_name": "MED20",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q6P2C8-1",
                "protein_name": "Mediator of RNA polymerase II transcription subunit 27",
                "gene_name": "MED27",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9ULK4-1",
                "protein_name": "Mediator of RNA polymerase II transcription subunit 23",
                "gene_name": "MED23",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O60244-1",
                "protein_name": "Mediator of RNA polymerase II transcription subunit 14",
                "gene_name": "MED14",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9BTT4-1",
                "protein_name": "Mediator of RNA polymerase II transcription subunit 10",
                "gene_name": "MED10",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O15550-1",
                "protein_name": "Lysine-specific demethylase 6A",
                "gene_name": "KDM6A",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O15120-1",
                "protein_name": "1-acyl-sn-glycerol-3-phosphate acyltransferase beta",
                "gene_name": "AGPAT2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O75586-1",
                "protein_name": "Mediator of RNA polymerase II transcription subunit 6",
                "gene_name": "MED6",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q96PD7-1",
                "protein_name": "Diacylglycerol O-acyltransferase 2",
                "gene_name": "DGAT2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O43513-1",
                "protein_name": "Mediator of RNA polymerase II transcription subunit 7",
                "gene_name": "MED7",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O00482-1",
                "protein_name": "Nuclear receptor subfamily 5 group A member 2",
                "gene_name": "NR5A2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P15090-1",
                "protein_name": "Fatty acid-binding protein, adipocyte",
                "gene_name": "FABP4",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O15379-1",
                "protein_name": "Histone deacetylase 3",
                "gene_name": "HDAC3",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9UBL3-1",
                "protein_name": "Set1/Ash2 histone methyltransferase complex subunit ASH2",
                "gene_name": "ASH2L",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9C005-1",
                "protein_name": "Protein dpy-30 homolog",
                "gene_name": "DPY30",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P61964-1",
                "protein_name": "WD repeat-containing protein 5",
                "gene_name": "WDR5",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O00767-1",
                "protein_name": "Stearoyl-CoA desaturase",
                "gene_name": "SCD",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P33121-1",
                "protein_name": "Long-chain-fatty-acid--CoA ligase 1",
                "gene_name": "ACSL1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P62805-1",
                "protein_name": "Histone H4",
                "gene_name": "H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P68431-1",
                "protein_name": "Histone H3.1",
                "gene_name": "H3C10; H3C11; H3C12; H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9H6R3-1",
                "protein_name": "Acyl-CoA synthetase short-chain family member 3, mitochondrial",
                "gene_name": "ACSS3",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q96IF1-1",
                "protein_name": "LIM domain-containing protein ajuba",
                "gene_name": "AJUBA",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q09472-1",
                "protein_name": "Histone acetyltransferase p300",
                "gene_name": "EP300",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9NPJ6-1",
                "protein_name": "Mediator of RNA polymerase II transcription subunit 4",
                "gene_name": "MED4",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q16778-1",
                "protein_name": "Histone H2B type 2-E",
                "gene_name": "H2BC21",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P62807-1",
                "protein_name": "Histone H2B type 1-C/E/F/G/I",
                "gene_name": "H2BC10; H2BC4; H2BC6; H2BC7; H2BC8",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P22736-1",
                "protein_name": "Nuclear receptor subfamily 4immunitygroup A member 1",
                "gene_name": "NR4A1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O14686-1",
                "protein_name": "Histone-lysine N-methyltransferase 2D",
                "gene_name": "KMT2D",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q96AQ7-1",
                "protein_name": "Lipid transferase CIDEC",
                "gene_name": "CIDEC",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9Y3C7-1",
                "protein_name": "Mediator of RNA polymerase II transcription subunit 31",
                "gene_name": "MED31",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9UBK2-1",
                "protein_name": "Peroxisome proliferator-activated receptor gamma coactivator 1-alpha",
                "gene_name": "PPARGC1A",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q71DI3-1",
                "protein_name": "Histone H3.2",
                "gene_name": "H3C13; H3C14; H3C15",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q00535-1",
                "protein_name": "Cyclin-dependent kinase 5",
                "gene_name": "CDK5",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P16104-1",
                "protein_name": "Histone H2AX",
                "gene_name": "H2AX",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P48443-1",
                "protein_name": "Retinoic acid receptor RXR-gamma",
                "gene_name": "RXRG",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9HCL2-1",
                "protein_name": "Glycerol-3-phosphate acyltransferase 1, mitochondrial",
                "gene_name": "GPAM",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P33778-1",
                "protein_name": "Histone H2B type 1-B",
                "gene_name": "H2BC3",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P58876-1",
                "protein_name": "Histone H2B type 1-D",
                "gene_name": "H2BC5",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q96A08-1",
                "protein_name": "Histone H2B type 1-A",
                "gene_name": "H2BC1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P23527-1",
                "protein_name": "Histone H2B type 1-O",
                "gene_name": "H2BC17",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P0C5Y9-1",
                "protein_name": "Histone H2A-Bbd type 1",
                "gene_name": "H2AB1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q99541-1",
                "protein_name": "Perilipin-2",
                "gene_name": "PLIN2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q96Q06-1",
                "protein_name": "Perilipin-4",
                "gene_name": "PLIN4",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q96AD5-1",
                "protein_name": "Patatin-like phospholipase domain-containing protein 2",
                "gene_name": "PNPLA2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O60240-1",
                "protein_name": "Perilipin-1",
                "gene_name": "PLIN1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O75192-1",
                "protein_name": "Peroxisomal membrane protein 11A",
                "gene_name": "PEX11A",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q86YN6-1",
                "protein_name": "Peroxisome proliferator-activated receptor gamma coactivator 1-beta",
                "gene_name": "PPARGC1B",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9BTM1-1",
                "protein_name": "Histone H2A.J",
                "gene_name": "H2AJ",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O60814-1",
                "protein_name": "Histone H2B type 1-K",
                "gene_name": "H2BC12",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q93077-1",
                "protein_name": "Histone H2A type 1-C",
                "gene_name": "H2AC6",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q93079-1",
                "protein_name": "Histone H2B type 1-H",
                "gene_name": "H2BC9",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q99879-1",
                "protein_name": "Histone H2B type 1-M",
                "gene_name": "H2BC14",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q92748-1",
                "protein_name": "Thyroid hormone-inducible hepatic protein",
                "gene_name": "THRSP",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P24863-1",
                "protein_name": "Cyclin-C",
                "gene_name": "CCNC",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P49336-1",
                "protein_name": "Cyclin-dependent kinase 8",
                "gene_name": "CDK8",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O75376-1",
                "protein_name": "Nuclear receptor corepressor 1",
                "gene_name": "NCOR1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q96HR3-1",
                "protein_name": "Mediator of RNA polymerase II transcription subunit 30",
                "gene_name": "MED30",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q15788-1",
                "protein_name": "Nuclear receptor coactivator 1",
                "gene_name": "NCOA1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9BTK6-1",
                "protein_name": "PAXIP1-associated glutamate-rich protein 1",
                "gene_name": "PAGR1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q71UI9-1",
                "protein_name": "Histone H2A.V",
                "gene_name": "H2AZ2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P04908-1",
                "protein_name": "Histone H2A type 1-B/E",
                "gene_name": "H2AC4; H2AC8",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P06899-1",
                "protein_name": "Histone H2B type 1-J",
                "gene_name": "H2BC11",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P20671-1",
                "protein_name": "Histone H2A type 1-D",
                "gene_name": "H2AC7",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P57053-1",
                "protein_name": "Histone H2B type F-S",
                "gene_name": "H2BC12L",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q16777-1",
                "protein_name": "Histone H2A type 2-C",
                "gene_name": "H2AC20",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q6FI13-1",
                "protein_name": "Histone H2A type 2-A",
                "gene_name": "H2AC18; H2AC19",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8N257-1",
                "protein_name": "Histone H2B type 3-B",
                "gene_name": "H2BC26",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q99877-1",
                "protein_name": "Histone H2B type 1-N",
                "gene_name": "H2BC15",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q99878-1",
                "protein_name": "Histone H2A type 1-J",
                "gene_name": "H2AC14",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q99880-1",
                "protein_name": "Histone H2B type 1-L",
                "gene_name": "H2BC13",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P06858-1",
                "protein_name": "Lipoprotein lipase",
                "gene_name": "LPL",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8WV24-1",
                "protein_name": "Pleckstrin homology-like domain family A member 1",
                "gene_name": "PHLDA1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P00519-1",
                "protein_name": "Tyrosine-protein kinase ABL1",
                "gene_name": "ABL1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q96EB6-1",
                "protein_name": "NAD-dependent protein deacetylase sirtuin-1",
                "gene_name": "SIRT1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q93074-1",
                "protein_name": "Mediator of RNA polymerase II transcription subunit 12",
                "gene_name": "MED12",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q99685-1",
                "protein_name": "Monoglyceride lipase",
                "gene_name": "MGLL",
                "tax_name": "Human"
            }
        ],
        "species": [
            {
                "name": "Homo sapiens",
                "taxid": 9606,
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q15848",
                        "url": "https://www.uniprot.org/uniprotkb/Q15848"
                    }
                ],
                "common_name": "Human",
                "glygen_name": "Human",
                "reference_species": "Homo sapiens [9606]"
            }
        ],
        "mutagenesis": [
            {
                "start_pos": 133,
                "end_pos": 156,
                "sequence_org": "HICAICGDRSSGKHYGVYSCEGCK",
                "sequence_mut": "",
                "comment": "Abolishes acetylation by EP300.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P19793",
                        "url": "https://www.uniprot.org/uniprotkb/P19793"
                    },
                    {
                        "database": "PubMed",
                        "id": "17761950",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/17761950"
                    }
                ],
                "uniprot_canonical_ac": "P19793-1"
            },
            {
                "start_pos": 145,
                "end_pos": 145,
                "sequence_org": "K",
                "sequence_mut": "R",
                "comment": "Abolishes acetylation by EP300, DNA binding and transcriptional activity. Impairs interaction with EP300.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P19793",
                        "url": "https://www.uniprot.org/uniprotkb/P19793"
                    },
                    {
                        "database": "PubMed",
                        "id": "17761950",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/17761950"
                    }
                ],
                "uniprot_canonical_ac": "P19793-1"
            },
            {
                "start_pos": 206,
                "end_pos": 216,
                "sequence_org": "QEERQRGKDRN",
                "sequence_mut": "",
                "comment": "No impact on acetylation by EP300.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P19793",
                        "url": "https://www.uniprot.org/uniprotkb/P19793"
                    },
                    {
                        "database": "PubMed",
                        "id": "17761950",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/17761950"
                    }
                ],
                "uniprot_canonical_ac": "P19793-1"
            },
            {
                "start_pos": 352,
                "end_pos": 462,
                "sequence_org": "ELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT",
                "sequence_mut": "",
                "comment": "No impact on acetylation by EP300.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P19793",
                        "url": "https://www.uniprot.org/uniprotkb/P19793"
                    },
                    {
                        "database": "PubMed",
                        "id": "17761950",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/17761950"
                    }
                ],
                "uniprot_canonical_ac": "P19793-1"
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            {
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    {
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                "tax_name": "Human"
            },
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            },
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                "uniprot_canonical_ac": "Q16654-1",
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                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "O60907-1",
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            {
                "uniprot_canonical_ac": "P84243-1",
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                "uniprot_canonical_ac": "Q9BZK7-1",
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                "uniprot_canonical_ac": "Q9Y6Q9-1",
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                "name": "Homo sapiens",
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        ],
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                "start_pos": 273,
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                "kinase_uniprot_canonical_ac": "",
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                "residue": "Ser",
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                        "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P37231"
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                ],
                "site_lbl": "Ser273",
                "uniprot_canonical_ac": "P37231-1"
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        ],
        "record_id": "pubmed.33329381",
        "abstract": "",
        "glycosylation": [],
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        "title": "A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation.",
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        "title": "Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma.",
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        "authors": "Nakano Y, Tobe T, Choi-Miura NH, Mazda T, Tomita M",
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        "abstract": "",
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    {
        "title": "Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma.",
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