[ { "title": "Hypoxia-inducible factor 3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia.", "journal": "Cell reports", "date": "2014", "authors": "Zhang P, Yao Q, Lu L, Li Y, Chen PJ, Duan C", "reference": { "type": "PubMed", "id": "24613356", "url": "https://pubmed.ncbi.nlm.nih.gov/24613356" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92793-1", "protein_name": "CREB-binding protein", "gene_name": "CREBBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27540-1", "protein_name": "Aryl hydrocarbon receptor nuclear translocator", "gene_name": "ARNT", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99967-1", "protein_name": "Cbp/p300-interacting transactivator 2", "gene_name": "CITED2", "tax_name": "Human" }, { "uniprot_canonical_ac": "A0A2R8QUQ1-1", 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M, Wang Q, Voena C, Chiarle R", "reference": { "type": "PubMed", "id": "25193384", "url": "https://pubmed.ncbi.nlm.nih.gov/25193384" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P26358-1", "protein_name": "DNA (cytosine-5)-methyltransferase 1", "gene_name": "DNMT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13547-1", "protein_name": "Histone deacetylase 1", "gene_name": "HDAC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P31785-1", "protein_name": "Cytokine receptor common subunit gamma", "gene_name": "IL2RG", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75626-1", "protein_name": "PR domain zinc finger protein 1", "gene_name": "PRDM1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NZQ7-1", "protein_name": "Programmed cell death 1 ligand 1", "gene_name": "CD274", "tax_name": "Human" }, { 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth.", "journal": "Cell reports", "date": "2015", "authors": "Ameri K, Jahangiri A, Rajah AM, Tormos KV, Nagarajan R, Pekmezci M, Nguyen V, Wheeler ML, Murphy MP, Sanders TA, Jeffrey SS, Yeghiazarians Y, Rinaudo PF, Costello JF, Aghi MK, Maltepe E", "reference": { "type": "PubMed", "id": "25683712", "url": "https://pubmed.ncbi.nlm.nih.gov/25683712" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92793-1", "protein_name": "CREB-binding protein", "gene_name": "CREBBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27540-1", "protein_name": 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "MLL3 enhances the transcription of PD-L1 and regulates anti-tumor immunity.", "journal": "Biochimica et biophysica acta. 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"gene_name": "STAT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15561-1", "protein_name": "Transcriptional enhancer factor TEF-3", "gene_name": "TEAD4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q71UI9-1", "protein_name": "Histone H2A.V", "gene_name": "H2AZ2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04908-1", "protein_name": "Histone H2A type 1-B/E", "gene_name": "H2AC4; H2AC8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P06899-1", "protein_name": "Histone H2B type 1-J", "gene_name": "H2BC11", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20671-1", "protein_name": "Histone H2A type 1-D", "gene_name": "H2AC7", "tax_name": "Human" }, { "uniprot_canonical_ac": "P57053-1", "protein_name": "Histone H2B type F-S", "gene_name": "H2BC12L", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16777-1", "protein_name": "Histone H2A type 2-C", "gene_name": "H2AC20", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6FI13-1", "protein_name": "Histone H2A type 2-A", "gene_name": "H2AC18; H2AC19", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N257-1", "protein_name": "Histone H2B type 3-B", "gene_name": "H2BC26", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99877-1", "protein_name": "Histone H2B type 1-N", "gene_name": "H2BC15", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99878-1", "protein_name": "Histone H2A type 1-J", "gene_name": "H2AC14", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99880-1", "protein_name": "Histone H2B type 1-L", "gene_name": "H2BC13", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15022-1", "protein_name": "Polycomb protein SUZ12", "gene_name": "SUZ12", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99594-1", "protein_name": "Transcriptional enhancer factor TEF-5", "gene_name": "TEAD3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01100-1", "protein_name": "Protein c-Fos", "gene_name": "FOS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05412-1", "protein_name": "Transcription factor Jun", "gene_name": "JUN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46937-1", "protein_name": "Transcriptional coactivator YAP1", "gene_name": "YAP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9GZV5-1", "protein_name": "WW domain-containing transcription regulator protein 1", "gene_name": "WWTR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04206-1", "protein_name": "Transcription factor p65", "gene_name": "RELA", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.30385408", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 69 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis.", "journal": "Cancer cell", "date": "2020", "authors": "Liu H, Kuang X, Zhang Y, Ye Y, Li J, Liang L, Xie Z, Weng L, Guo J, Li H, Ma F, Chen X, Zhao S, Su J, Yang N, Fang F, Xie Y, Tao J, Zhang J, Chen M, Peng C, Sun L, Zhang X, Liu J, Han L, Xu X, Hung MC, Chen X", "reference": { "type": "PubMed", "id": "32183950", "url": "https://pubmed.ncbi.nlm.nih.gov/32183950" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92793-1", "protein_name": "CREB-binding protein", "gene_name": "CREBBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18847-1", "protein_name": "Cyclic AMP-dependent transcription factor ATF-3", "gene_name": "ATF3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04198-1", "protein_name": "N-myc proto-oncogene protein", "gene_name": "MYCN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NEZ4-1", "protein_name": "Histone-lysine N-methyltransferase 2C", "gene_name": "KMT2C", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15291-1", "protein_name": "Retinoblastoma-binding protein 5", "gene_name": "RBBP5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19838-1", "protein_name": "Nuclear factor NF-kappa-B p105 subunit", "gene_name": "NFKB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16576-1", "protein_name": "Histone-binding protein RBBP7", "gene_name": "RBBP7", "tax_name": "Human" }, { "uniprot_canonical_ac": "P53539-1", "protein_name": "Protein FosB", "gene_name": "FOSB", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75530-1", "protein_name": "Polycomb protein EED", "gene_name": "EED", "tax_name": "Human" }, { "uniprot_canonical_ac": "P84243-1", "protein_name": "Histone H3.3", "gene_name": "H3-3A; H3-3B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15910-1", "protein_name": "Histone-lysine N-methyltransferase EZH2", "gene_name": "EZH2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99814-1", "protein_name": "Endothelial PAS domain-containing protein 1", "gene_name": "EPAS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36402-5", "protein_name": "Transcription factor 7", "gene_name": "TCF7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UJU2-1", "protein_name": "Lymphoid enhancer-binding factor 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"Human" }, { "uniprot_canonical_ac": "Q9C005-1", "protein_name": "Protein dpy-30 homolog", "gene_name": "DPY30", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61964-1", "protein_name": "WD repeat-containing protein 5", "gene_name": "WDR5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62805-1", "protein_name": "Histone H4", "gene_name": "H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9", "tax_name": "Human" }, { "uniprot_canonical_ac": "P68431-1", "protein_name": "Histone H3.1", "gene_name": "H3C10; H3C11; H3C12; H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q09472-1", "protein_name": "Histone acetyltransferase p300", "gene_name": "EP300", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16778-1", "protein_name": "Histone H2B type 2-E", "gene_name": "H2BC21", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62807-1", "protein_name": "Histone H2B type 1-C/E/F/G/I", "gene_name": "H2BC10; H2BC4; H2BC6; H2BC7; H2BC8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P17535-1", "protein_name": "Transcription factor JunD", "gene_name": "JUND", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q03164-1", "protein_name": "Histone-lysine N-methyltransferase 2A", "gene_name": "KMT2A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P40763-1", "protein_name": "Signal transducer and activator of transcription 3", "gene_name": "STAT3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q71DI3-1", "protein_name": "Histone H3.2", "gene_name": "H3C13; H3C14; H3C15", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60885-1", "protein_name": "Bromodomain-containing protein 4", "gene_name": "BRD4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01106-2", "protein_name": "Myc proto-oncogene protein", "gene_name": "MYC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P16104-1", "protein_name": "Histone H2AX", "gene_name": "H2AX", "tax_name": "Human" }, { "uniprot_canonical_ac": "P33778-1", "protein_name": "Histone H2B type 1-B", "gene_name": "H2BC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P58876-1", "protein_name": "Histone H2B type 1-D", "gene_name": "H2BC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96A08-1", "protein_name": "Histone H2B type 1-A", "gene_name": "H2BC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P23527-1", "protein_name": "Histone H2B type 1-O", "gene_name": "H2BC17", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0C5Y9-1", "protein_name": "Histone H2A-Bbd type 1", "gene_name": "H2AB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BTM1-1", "protein_name": "Histone H2A.J", "gene_name": "H2AJ", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60814-1", "protein_name": "Histone H2B type 1-K", "gene_name": "H2BC12", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q93077-1", "protein_name": "Histone H2A type 1-C", "gene_name": "H2AC6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q93079-1", "protein_name": "Histone H2B type 1-H", "gene_name": "H2BC9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99879-1", "protein_name": "Histone H2B type 1-M", "gene_name": "H2BC14", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HCS4-1", "protein_name": "Transcription factor 7-like 1", "gene_name": "TCF7L1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P28347-1", "protein_name": "Transcriptional enhancer factor TEF-1", "gene_name": "TEAD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15562-1", "protein_name": "Transcriptional enhancer factor TEF-4", "gene_name": "TEAD2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42224-1", "protein_name": "Signal transducer and activator of transcription 1-alpha/beta", "gene_name": "STAT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15561-1", "protein_name": "Transcriptional enhancer factor TEF-3", "gene_name": "TEAD4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q71UI9-1", "protein_name": "Histone H2A.V", "gene_name": "H2AZ2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04908-1", "protein_name": "Histone H2A type 1-B/E", "gene_name": "H2AC4; H2AC8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P06899-1", "protein_name": "Histone H2B type 1-J", "gene_name": "H2BC11", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20671-1", "protein_name": "Histone H2A type 1-D", "gene_name": "H2AC7", "tax_name": "Human" }, { "uniprot_canonical_ac": "P57053-1", "protein_name": "Histone H2B type F-S", "gene_name": "H2BC12L", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16777-1", "protein_name": "Histone H2A type 2-C", "gene_name": "H2AC20", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6FI13-1", "protein_name": "Histone H2A type 2-A", "gene_name": "H2AC18; H2AC19", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N257-1", "protein_name": "Histone H2B type 3-B", "gene_name": "H2BC26", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99877-1", "protein_name": "Histone H2B type 1-N", "gene_name": "H2BC15", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99878-1", "protein_name": "Histone H2A type 1-J", "gene_name": "H2AC14", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99880-1", "protein_name": "Histone H2B type 1-L", "gene_name": "H2BC13", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15022-1", "protein_name": "Polycomb protein SUZ12", "gene_name": "SUZ12", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99594-1", "protein_name": "Transcriptional enhancer factor TEF-5", "gene_name": "TEAD3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01100-1", "protein_name": "Protein c-Fos", "gene_name": "FOS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05412-1", "protein_name": "Transcription factor Jun", "gene_name": "JUN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46937-1", "protein_name": "Transcriptional coactivator YAP1", "gene_name": "YAP1", "tax_name": "Human" }, { "uniprot_canonical_ac": 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Rafael Elias, Carmo Helison R, Borin Alexandre, Coimbra La\u00eds Dur\u00e7o, Boldrini Vin\u00edcius O, Brunetti Natalia S, Vieira Andre S, Mansour Eli, Ulaf Raisa G, Bernardes Ana F, Nunes Thyago A, Ribeiro Luciana C, Palma Andre C, Agrela Marcus V, Moretti Maria Luiza, Sposito Andrei C, Pereira Fabr\u00edcio B\u00edscaro, Velloso Licio Augusto, Vinolo Marco Aur\u00e9lio Ramirez, Damasio Andr\u00e9, Proen\u00e7a-M\u00f3dena Jos\u00e9 Luiz, Carvalho Robson Francisco, Mori Marcelo A, Martins-de-Souza Daniel, Nakaya Helder I, Farias Alessandro S, Moraes-Vieira Pedro M", "reference": { "type": "PubMed", "id": "32697943", "url": "https://pubmed.ncbi.nlm.nih.gov/32697943" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": 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Xinjian, Kim Hyung-Ryong, Xing Dongming, Liu Pengyuan, Lu Zhimin, Lyu Jianxin", "reference": { "type": "PubMed", "id": "32860047", "url": "https://pubmed.ncbi.nlm.nih.gov/32860047" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92793-1", "protein_name": "CREB-binding protein", "gene_name": "CREBBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18847-1", "protein_name": "Cyclic AMP-dependent transcription factor ATF-3", "gene_name": "ATF3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04198-1", "protein_name": "N-myc proto-oncogene protein", "gene_name": "MYCN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NEZ4-1", "protein_name": "Histone-lysine N-methyltransferase 2C", "gene_name": "KMT2C", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15291-1", "protein_name": "Retinoblastoma-binding protein 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"gene_name": "CTNNB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBL3-1", "protein_name": "Set1/Ash2 histone methyltransferase complex subunit ASH2", "gene_name": "ASH2L", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9C005-1", "protein_name": "Protein dpy-30 homolog", "gene_name": "DPY30", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61964-1", "protein_name": "WD repeat-containing protein 5", "gene_name": "WDR5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62805-1", "protein_name": "Histone H4", "gene_name": "H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9", "tax_name": "Human" }, { "uniprot_canonical_ac": "P68431-1", "protein_name": "Histone H3.1", "gene_name": "H3C10; H3C11; H3C12; H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q09472-1", "protein_name": "Histone acetyltransferase p300", "gene_name": "EP300", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16778-1", 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"gene_name": "H2BC12", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q93077-1", "protein_name": "Histone H2A type 1-C", "gene_name": "H2AC6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q93079-1", "protein_name": "Histone H2B type 1-H", "gene_name": "H2BC9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99879-1", "protein_name": "Histone H2B type 1-M", "gene_name": "H2BC14", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HCS4-1", "protein_name": "Transcription factor 7-like 1", "gene_name": "TCF7L1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P28347-1", "protein_name": "Transcriptional enhancer factor TEF-1", "gene_name": "TEAD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15562-1", "protein_name": "Transcriptional enhancer factor TEF-4", "gene_name": "TEAD2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42224-1", "protein_name": "Signal transducer and activator of transcription 1-alpha/beta", "gene_name": "STAT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15561-1", "protein_name": "Transcriptional enhancer factor TEF-3", "gene_name": "TEAD4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q71UI9-1", "protein_name": "Histone H2A.V", "gene_name": "H2AZ2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04908-1", "protein_name": "Histone H2A type 1-B/E", "gene_name": "H2AC4; H2AC8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P06899-1", "protein_name": "Histone H2B type 1-J", "gene_name": "H2BC11", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20671-1", "protein_name": "Histone H2A type 1-D", "gene_name": "H2AC7", "tax_name": "Human" }, { "uniprot_canonical_ac": "P57053-1", "protein_name": "Histone H2B type F-S", "gene_name": "H2BC12L", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16777-1", "protein_name": "Histone H2A type 2-C", "gene_name": "H2AC20", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6FI13-1", "protein_name": "Histone H2A type 2-A", "gene_name": "H2AC18; H2AC19", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N257-1", "protein_name": "Histone H2B type 3-B", "gene_name": "H2BC26", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99877-1", "protein_name": "Histone H2B type 1-N", "gene_name": "H2BC15", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99878-1", "protein_name": "Histone H2A type 1-J", "gene_name": "H2AC14", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99880-1", "protein_name": "Histone H2B type 1-L", "gene_name": "H2BC13", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15022-1", "protein_name": "Polycomb protein SUZ12", "gene_name": "SUZ12", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99594-1", "protein_name": "Transcriptional enhancer factor TEF-5", "gene_name": "TEAD3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01100-1", "protein_name": "Protein c-Fos", "gene_name": "FOS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05412-1", "protein_name": "Transcription factor Jun", "gene_name": "JUN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46937-1", "protein_name": "Transcriptional coactivator YAP1", "gene_name": "YAP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9GZV5-1", "protein_name": "WW domain-containing transcription regulator protein 1", "gene_name": "WWTR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04206-1", "protein_name": "Transcription factor p65", "gene_name": "RELA", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.32860047", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 69 } ], "sort_fields": [ "uniprot_canonical_ac", 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], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Alternative regulation of HIF-1\u03b1 stability through Phosphorylation on Ser451.", "journal": "Biochemical and biophysical research communications", "date": "2021-03-19", "authors": "Han Hyeong-Jun, Saeidi Soma, Kim Su-Jung, Piao Juan-Yu, Lim Sooa, Guillen-Quispe Yanymee N, Choi Bu Young, Surh Young-Joon", "reference": { "type": "PubMed", "id": "33550096", "url": "https://pubmed.ncbi.nlm.nih.gov/33550096" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "phosphorylation": [ { "start_pos": 451, "end_pos": 451, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q16665", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q16665" }, { "database": "PubMed", "id": "33550096", "url": "https://pubmed.ncbi.nlm.nih.gov/33550096" } ], "site_lbl": "Ser451", "uniprot_canonical_ac": "Q16665-1" } ], "record_id": "pubmed.33550096", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": 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"o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Pilot Study on the Effect of Patient Condition and Clinical Parameters on Hypoxia-Induced Factor Expression: HIF1A, EPAS1 and HIF3A in Human Colostrum Cells.", "journal": "International journal of molecular sciences", "date": "2024-10-14", "authors": "Zarychta Julia, Kowalczyk Adrian, S\u0142owik Karolina, Przywara Dominika, Petniak Alicja, Kondracka Adrianna, W\u00f3jtowicz-Marzec Monika, S\u0142yk-Gulewska Patrycja, Kwa\u015bniewska Anna, Kocki Janusz, Gil-Kulik Paulina", "reference": { "type": "PubMed", "id": "39456823", "url": "https://pubmed.ncbi.nlm.nih.gov/39456823" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99814-1", "protein_name": 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Impact of Hypoxia and the Levels of Transcription Factor HIF-1\u03b1 and JMJD1A on Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma Cell Lines.", "journal": "Cancer genomics & proteomics", "date": "2024", "authors": "VON Fournier Armin, Wilhelm Christian, Tirtey Clara, St\u00f6th Manuel, Kasemo Totta Ehret, Hackenberg Stephan, Scherzad Agmal", "reference": { "type": "PubMed", "id": "39467631", "url": "https://pubmed.ncbi.nlm.nih.gov/39467631" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y4C1-1", "protein_name": "Lysine-specific demethylase 3A", "gene_name": "KDM3A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.39467631", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 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"\u03b22-integrins control HIF1\u03b1 activation in human neutrophils.", "journal": "Frontiers in immunology", "date": "2024", "authors": "Kling Lovis, Eulenberg-Gustavus Claudia, Jerke Uwe, Rousselle Anthony, Eckardt Kai-Uwe, Schreiber Adrian, Kettritz Ralph", "reference": { "type": "PubMed", "id": "39469705", "url": "https://pubmed.ncbi.nlm.nih.gov/39469705" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05107-1", "protein_name": "Integrin beta-2", "gene_name": "ITGB2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.39469705", "abstract": "", "glycosylation": 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"count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Decreased OGT Attenuates Endometrial Decidualization and Embryo Implantation by Affecting HIF-1\u03b1 Stability.", "journal": "Molecular reproduction and development", "date": "2025-05", "authors": "Li Bo, Jin Ni, Lu Jie, Wang Ming, Wang Jun, Chen Shuqiang", "reference": { "type": "PubMed", "id": "40342239", "url": "https://pubmed.ncbi.nlm.nih.gov/40342239" }, "referenced_glycans": [ { "glytoucan_ac": "G49108TO" } ], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "evidence": [ { "id": "40342239", "database": "PubMed", "url": 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"glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "filter_code", "uniprot_canonical_ac" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1995", "authors": "Wang GL, Jiang BH, Rue EA, Semenza GL", "reference": { "type": "PubMed", "id": "7539918", "url": "https://pubmed.ncbi.nlm.nih.gov/7539918" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92793-1", "protein_name": "CREB-binding protein", "gene_name": "CREBBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27540-1", "protein_name": "Aryl hydrocarbon receptor nuclear translocator", "gene_name": "ARNT", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99967-1", "protein_name": "Cbp/p300-interacting transactivator 2", "gene_name": "CITED2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99814-1", "protein_name": "Endothelial PAS domain-containing protein 1", "gene_name": "EPAS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q09472-1", "protein_name": "Histone acetyltransferase p300", "gene_name": "EP300", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16790-1", "protein_name": "Carbonic anhydrase 9", "gene_name": "CA9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y241-1", "protein_name": "HIG1 domain family member 1A, mitochondrial", "gene_name": "HIGD1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15692-13", "protein_name": "Vascular endothelial growth factor A, long form", "gene_name": "VEGFA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01588-1", "protein_name": "Erythropoietin", "gene_name": "EPO", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.7539918", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 10 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": 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"Human" }, { "uniprot_canonical_ac": "P56524-1", "protein_name": "Histone deacetylase 4", "gene_name": "HDAC4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63208-1", "protein_name": "S-phase kinase-associated protein 1", "gene_name": "SKP1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.7566092", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 63 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": 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"glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Disruption of the mouse RBP-J kappa gene results in early embryonic death.", "journal": "Development (Cambridge, England)", "date": "1995", "authors": "Oka C, Nakano T, Wakeham A, de la Pompa JL, Mori C, Sakai T, Okazaki S, Kawaichi M, Shiota K, Mak TW, Honjo T", "reference": { "type": "PubMed", "id": "7588063", "url": "https://pubmed.ncbi.nlm.nih.gov/7588063" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92793-1", "protein_name": "CREB-binding protein", "gene_name": "CREBBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y618-1", "protein_name": "Nuclear receptor corepressor 2", "gene_name": "NCOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P78536-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 17", "gene_name": "ADAM17", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92542-1", "protein_name": "Nicastrin", "gene_name": "NCSTN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96BI3-1", "protein_name": "Gamma-secretase subunit APH-1A", "gene_name": "APH1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13616-1", "protein_name": "Cullin-1", "gene_name": "CUL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13547-1", "protein_name": "Histone deacetylase 1", "gene_name": "HDAC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NR61-1", "protein_name": "Delta-like protein 4", "gene_name": 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ubiquitin-protein ligase MIB1", "gene_name": "MIB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96JK9-1", "protein_name": "Mastermind-like protein 3", "gene_name": "MAML3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00548-1", "protein_name": "Delta-like protein 1", "gene_name": "DLL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15379-1", "protein_name": "Histone deacetylase 3", "gene_name": "HDAC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WUI4-1", "protein_name": "Histone deacetylase 7", "gene_name": "HDAC7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UQL6-1", "protein_name": "Histone deacetylase 5", "gene_name": "HDAC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q09472-1", "protein_name": "Histone acetyltransferase p300", "gene_name": "EP300", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WW43-1", "protein_name": "Gamma-secretase subunit APH-1B", "gene_name": "APH1B", "tax_name": "Human" }, { "uniprot_canonical_ac": 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Purification and characterization of hypoxia-inducible factor 1.", "journal": "The Journal of biological chemistry", "date": "1995", "authors": "Wang GL, Semenza GL", "reference": { "type": "PubMed", "id": "7836384", "url": "https://pubmed.ncbi.nlm.nih.gov/7836384" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92793-1", "protein_name": "CREB-binding protein", "gene_name": "CREBBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27540-1", "protein_name": "Aryl hydrocarbon receptor nuclear translocator", "gene_name": "ARNT", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99967-1", "protein_name": "Cbp/p300-interacting transactivator 2", "gene_name": "CITED2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99814-1", "protein_name": "Endothelial PAS domain-containing protein 1", "gene_name": "EPAS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q09472-1", "protein_name": "Histone acetyltransferase p300", "gene_name": "EP300", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16790-1", "protein_name": "Carbonic anhydrase 9", "gene_name": "CA9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y241-1", "protein_name": "HIG1 domain family member 1A, mitochondrial", "gene_name": "HIGD1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15692-13", "protein_name": "Vascular endothelial growth factor A, long form", "gene_name": "VEGFA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01588-1", "protein_name": "Erythropoietin", "gene_name": "EPO", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], 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hairy-related bHLH proteins.", "journal": "Cell", "date": "1994", "authors": "Paroush Z, Finley RL Jr, Kidd T, Wainwright SM, Ingham PW, Brent R, Ish-Horowicz D", "reference": { "type": "PubMed", "id": "8001118", "url": "https://pubmed.ncbi.nlm.nih.gov/8001118" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92793-1", "protein_name": "CREB-binding protein", "gene_name": "CREBBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y618-1", "protein_name": "Nuclear receptor corepressor 2", "gene_name": "NCOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13616-1", "protein_name": "Cullin-1", "gene_name": "CUL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13547-1", "protein_name": "Histone deacetylase 1", "gene_name": "HDAC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P13098-1", "protein_name": 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"gene_name": "HDAC9", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92769-1", "protein_name": "Histone deacetylase 2", "gene_name": "HDAC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01106-2", "protein_name": "Myc proto-oncogene protein", "gene_name": "MYC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96DB2-1", "protein_name": "Histone deacetylase 11", "gene_name": "HDAC11", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04724-1", "protein_name": "Transducin-like enhancer protein 1", "gene_name": "TLE1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQ87-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif-like protein", "gene_name": "HEYL", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q969S8-1", "protein_name": "Polyamine deacetylase HDAC10", "gene_name": "HDAC10", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBP5-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif protein 2", "gene_name": "HEY2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFP9-1", "protein_name": "Neurobeachin", "gene_name": "NBEA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92831-1", "protein_name": "Histone acetyltransferase KAT2B", "gene_name": "KAT2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24863-1", "protein_name": "Cyclin-C", "gene_name": "CCNC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49336-1", "protein_name": "Cyclin-dependent kinase 8", "gene_name": "CDK8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04725-1", "protein_name": "Transducin-like enhancer protein 2", "gene_name": "TLE2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75376-1", "protein_name": "Nuclear receptor corepressor 1", "gene_name": "NCOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13573-1", "protein_name": "SNW domain-containing protein 1", "gene_name": "SNW1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5J3-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif protein 1", "gene_name": "HEY1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BY41-1", "protein_name": "Histone deacetylase 8", "gene_name": "HDAC8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14469-1", "protein_name": "Transcription factor HES-1", "gene_name": "HES1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13495-1", "protein_name": "Mastermind-like domain-containing protein 1", "gene_name": "MAMLD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92585-1", "protein_name": "Mastermind-like protein 1", "gene_name": "MAML1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04727-1", "protein_name": "Transducin-like enhancer protein 4", "gene_name": "TLE4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56524-1", "protein_name": "Histone deacetylase 4", "gene_name": "HDAC4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63208-1", "protein_name": "S-phase kinase-associated protein 1", "gene_name": "SKP1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.8001118", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 54 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", 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"protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92793-1", "protein_name": "CREB-binding protein", "gene_name": "CREBBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27540-1", "protein_name": "Aryl hydrocarbon receptor nuclear translocator", "gene_name": "ARNT", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99967-1", "protein_name": "Cbp/p300-interacting transactivator 2", "gene_name": "CITED2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99814-1", "protein_name": "Endothelial PAS domain-containing protein 1", "gene_name": "EPAS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q09472-1", "protein_name": "Histone acetyltransferase p300", "gene_name": "EP300", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16790-1", "protein_name": "Carbonic anhydrase 9", "gene_name": "CA9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y241-1", "protein_name": "HIG1 domain family member 1A, 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"count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain.", "journal": "Molecular and cellular biology", "date": "1996", "authors": "Fisher AL, Ohsako S, Caudy M", "reference": { "type": "PubMed", "id": "8649374", "url": "https://pubmed.ncbi.nlm.nih.gov/8649374" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92793-1", "protein_name": "CREB-binding protein", "gene_name": "CREBBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y618-1", "protein_name": "Nuclear receptor corepressor 2", "gene_name": "NCOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13616-1", "protein_name": "Cullin-1", "gene_name": "CUL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13547-1", "protein_name": "Histone deacetylase 1", "gene_name": "HDAC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04666-1", "protein_name": "Transcription factor HES-1", "gene_name": "Hes1", "tax_name": "Rat" }, { "uniprot_canonical_ac": "P14003-1", "protein_name": "Protein hairy", "gene_name": "hry", "tax_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q5TA89-1", "protein_name": "Transcription factor HES-5", "gene_name": "HES5", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60907-1", "protein_name": "F-box-like/WD repeat-containing protein TBL1X", "gene_name": "TBL1X", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46531-1", "protein_name": "Neurogenic locus notch homolog protein 1", "gene_name": "NOTCH1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06330-1", "protein_name": "Recombining binding protein suppressor of hairless", "gene_name": "RBPJ", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BZK7-1", "protein_name": "F-box-like/WD repeat-containing protein TBL1XR1", "gene_name": "TBL1XR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBN7-1", "protein_name": "Protein deacetylase HDAC6", "gene_name": "HDAC6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IZL2-1", "protein_name": "Mastermind-like protein 2", "gene_name": "MAML2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92830-1", "protein_name": "Histone acetyltransferase KAT2A", "gene_name": "KAT2A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62877-1", "protein_name": "E3 ubiquitin-protein ligase RBX1", "gene_name": "RBX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96JK9-1", "protein_name": "Mastermind-like protein 3", "gene_name": "MAML3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P16371-1", "protein_name": "Protein groucho", "gene_name": "gro", "tax_name": "Fruit fly" }, { "uniprot_canonical_ac": "O15379-1", "protein_name": "Histone deacetylase 3", "gene_name": "HDAC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WUI4-1", "protein_name": "Histone deacetylase 7", "gene_name": "HDAC7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UQL6-1", "protein_name": "Histone deacetylase 5", "gene_name": "HDAC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q09472-1", "protein_name": "Histone acetyltransferase p300", "gene_name": "EP300", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UKV0-1", "protein_name": "Histone deacetylase 9", "gene_name": "HDAC9", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92769-1", "protein_name": "Histone deacetylase 2", "gene_name": "HDAC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01106-2", "protein_name": "Myc proto-oncogene protein", "gene_name": "MYC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96DB2-1", "protein_name": "Histone deacetylase 11", "gene_name": "HDAC11", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04724-1", "protein_name": "Transducin-like enhancer protein 1", "gene_name": "TLE1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQ87-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif-like protein", "gene_name": "HEYL", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q969S8-1", "protein_name": "Polyamine deacetylase HDAC10", "gene_name": "HDAC10", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBP5-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif protein 2", "gene_name": "HEY2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFP9-1", "protein_name": "Neurobeachin", "gene_name": "NBEA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92831-1", "protein_name": "Histone acetyltransferase KAT2B", "gene_name": "KAT2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24863-1", "protein_name": "Cyclin-C", "gene_name": "CCNC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49336-1", "protein_name": "Cyclin-dependent kinase 8", "gene_name": "CDK8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04725-1", "protein_name": "Transducin-like enhancer protein 2", "gene_name": "TLE2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75376-1", "protein_name": "Nuclear receptor corepressor 1", "gene_name": "NCOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13573-1", "protein_name": "SNW domain-containing protein 1", "gene_name": "SNW1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5J3-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif protein 1", "gene_name": "HEY1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BY41-1", "protein_name": "Histone deacetylase 8", "gene_name": "HDAC8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14469-1", "protein_name": "Transcription factor HES-1", "gene_name": "HES1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13495-1", "protein_name": "Mastermind-like domain-containing protein 1", "gene_name": "MAMLD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92585-1", "protein_name": "Mastermind-like protein 1", "gene_name": "MAML1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04727-1", "protein_name": "Transducin-like enhancer protein 4", "gene_name": "TLE4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56524-1", "protein_name": "Histone deacetylase 4", "gene_name": "HDAC4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63208-1", "protein_name": "S-phase kinase-associated protein 1", "gene_name": "SKP1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.8649374", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 49 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], 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"sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1.", "journal": "The Journal of biological chemistry", "date": "1996", "authors": "Jiang BH, Rue E, Wang GL, Roe R, Semenza GL", "reference": { "type": "PubMed", "id": "8663540", "url": "https://pubmed.ncbi.nlm.nih.gov/8663540" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92793-1", "protein_name": "CREB-binding protein", "gene_name": "CREBBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27540-1", "protein_name": "Aryl hydrocarbon receptor nuclear translocator", "gene_name": "ARNT", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99967-1", "protein_name": "Cbp/p300-interacting transactivator 2", "gene_name": "CITED2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99814-1", "protein_name": "Endothelial PAS domain-containing protein 1", "gene_name": "EPAS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q09472-1", "protein_name": "Histone acetyltransferase p300", "gene_name": "EP300", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16790-1", "protein_name": "Carbonic anhydrase 9", "gene_name": "CA9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y241-1", "protein_name": "HIG1 domain family member 1A, mitochondrial", "gene_name": "HIGD1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15692-13", "protein_name": "Vascular endothelial growth factor A, long form", "gene_name": "VEGFA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01588-1", "protein_name": "Erythropoietin", "gene_name": "EPO", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.8663540", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 10 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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Biol. Chem.", "date": "1997", "authors": "Hogenesch JB, Chan WK, Jackiw VH, Brown RC, Gu YZ, Pray-Grant M, Perdew GH, Bradfield CA", "reference": { "type": "PubMed", "id": "9079689", "url": "https://pubmed.ncbi.nlm.nih.gov/9079689" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92793-1", "protein_name": "CREB-binding protein", "gene_name": "CREBBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15596-1", "protein_name": "Nuclear receptor coactivator 2", "gene_name": "NCOA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14686-1", "protein_name": "Nuclear receptor coactivator 6", "gene_name": "NCOA6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15173-1", "protein_name": "Membrane-associated progesterone receptor component 2", "gene_name": "PGRMC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27540-1", 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[] } ] }, { "title": "Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension.", "journal": "J. Biol. Chem.", "date": "1997", "authors": "Jiang B H, Zheng J Z, Leung S W, Roe R, Semenza G L", "reference": { "type": "PubMed", "id": "9235919", "url": "https://pubmed.ncbi.nlm.nih.gov/9235919" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.9235919", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": 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}, { "uniprot_canonical_ac": "Q9BZK7-1", "protein_name": "F-box-like/WD repeat-containing protein TBL1XR1", "gene_name": "TBL1XR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBN7-1", "protein_name": "Protein deacetylase HDAC6", "gene_name": "HDAC6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P78504-1", "protein_name": "Protein jagged-1", "gene_name": "JAG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IZL2-1", "protein_name": "Mastermind-like protein 2", "gene_name": "MAML2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76050-1", "protein_name": "E3 ubiquitin-protein ligase NEURL1", "gene_name": "NEURL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92830-1", "protein_name": "Histone acetyltransferase KAT2A", "gene_name": "KAT2A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62877-1", "protein_name": "E3 ubiquitin-protein ligase RBX1", "gene_name": "RBX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86YT6-1", "protein_name": "E3 ubiquitin-protein ligase MIB1", "gene_name": "MIB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96JK9-1", "protein_name": "Mastermind-like protein 3", "gene_name": "MAML3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00548-1", "protein_name": "Delta-like protein 1", "gene_name": "DLL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15379-1", "protein_name": "Histone deacetylase 3", "gene_name": "HDAC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WUI4-1", "protein_name": "Histone deacetylase 7", "gene_name": "HDAC7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UQL6-1", "protein_name": "Histone deacetylase 5", "gene_name": "HDAC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q09472-1", "protein_name": "Histone acetyltransferase p300", "gene_name": "EP300", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WW43-1", "protein_name": "Gamma-secretase subunit APH-1B", "gene_name": "APH1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UKV0-1", "protein_name": "Histone deacetylase 9", "gene_name": "HDAC9", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92769-1", "protein_name": "Histone deacetylase 2", "gene_name": "HDAC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01106-2", "protein_name": "Myc proto-oncogene protein", "gene_name": "MYC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96DB2-1", "protein_name": "Histone deacetylase 11", "gene_name": "HDAC11", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04724-1", "protein_name": "Transducin-like enhancer protein 1", "gene_name": "TLE1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQ87-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif-like protein", "gene_name": "HEYL", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q969S8-1", "protein_name": "Polyamine deacetylase 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"protein_name": "Nuclear receptor corepressor 1", "gene_name": "NCOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13573-1", "protein_name": "SNW domain-containing protein 1", "gene_name": "SNW1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49810-1", "protein_name": "Presenilin-2", "gene_name": "PSEN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5J3-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif protein 1", "gene_name": "HEY1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y219-1", "protein_name": "Protein jagged-2", "gene_name": "JAG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BY41-1", "protein_name": "Histone deacetylase 8", "gene_name": "HDAC8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14469-1", "protein_name": "Transcription factor HES-1", "gene_name": "HES1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13495-1", "protein_name": "Mastermind-like domain-containing protein 1", "gene_name": "MAMLD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92585-1", "protein_name": "Mastermind-like protein 1", "gene_name": "MAML1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04727-1", "protein_name": "Transducin-like enhancer protein 4", "gene_name": "TLE4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49768-1", "protein_name": "Presenilin-1", "gene_name": "PSEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14672-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 10", "gene_name": "ADAM10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56524-1", "protein_name": "Histone deacetylase 4", "gene_name": "HDAC4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63208-1", "protein_name": "S-phase kinase-associated protein 1", "gene_name": "SKP1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.9694793", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 62 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", 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"count": 0 } ], "sort_fields": [] } ] }, { "title": "Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha.", "journal": "Gene expression", "date": "1998", "authors": "Gu YZ, Moran SM, Hogenesch JB, Wartman L, Bradfield CA", "reference": { "type": "PubMed", "id": "9840812", "url": "https://pubmed.ncbi.nlm.nih.gov/9840812" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92793-1", "protein_name": "CREB-binding protein", "gene_name": "CREBBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27540-1", "protein_name": "Aryl hydrocarbon receptor nuclear translocator", "gene_name": "ARNT", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99967-1", "protein_name": "Cbp/p300-interacting transactivator 2", "gene_name": "CITED2", "tax_name": "Human" }, { 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Genet.", "date": "2002", "authors": "Eymard-Pierre Eleonore, Lesca Gaetan, Dollet Sandra, Santorelli Filippo Maria, di Capua Matteo, Bertini Enrico, Boespflug-Tanguy Odile", "reference": { "type": "PubMed", "id": "12145748", "url": "https://pubmed.ncbi.nlm.nih.gov/12145748" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q96Q42-1", "protein_name": "Alsin", "gene_name": "ALS2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q96Q42", "url": "https://www.uniprot.org/uniprotkb/Q96Q42" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.12145748", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Insights into the Direct Oxidative Repair of Etheno Lesions: MD and QM/MM Study on the Substrate Scope of ALKBH2 and AlkB.", "journal": "DNA repair", "date": "2020", "authors": "Lenz SAP, Li D, Wetmore SD", "reference": { "type": "PubMed", "id": "33161373", "url": "https://pubmed.ncbi.nlm.nih.gov/33161373" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q6NS38-1", "protein_name": "DNA oxidative demethylase ALKBH2", "gene_name": "ALKBH2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q6NS38", "url": "https://www.uniprot.org/uniprotkb/Q6NS38" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.33161373", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": 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basic helix-loop-helix/leucine zipper protein Mlx in DNA binding and glucose-regulated transcription.", "journal": "Nucleic acids research", "date": "2007", "authors": "Ma L, Sham YY, Walters KJ, Towle HC", "reference": { "type": "PubMed", "id": "17148476", "url": "https://pubmed.ncbi.nlm.nih.gov/17148476" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9UH92-1", "protein_name": "Max-like protein X", "gene_name": "MLX", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NP71-1", "protein_name": "Carbohydrate-responsive element-binding protein", "gene_name": "MLXIPL", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49327-1", "protein_name": "Fatty acid synthase", "gene_name": "FASN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99943-1", "protein_name": "1-acyl-sn-glycerol-3-phosphate acyltransferase alpha", "gene_name": "AGPAT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00763-1", "protein_name": "Acetyl-CoA carboxylase 2", 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}, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, 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Genomic and precision medicine", "date": "2018", "authors": "Tamura N, Maejima Y, Matsumura T, Vega RB, Amiya E, Ito Y, Shiheido-Watanabe Y, Ashikaga T, Komuro I, Kelly DP, Hirao K, Isobe M", "reference": { "type": "PubMed", "id": "30354298", "url": "https://pubmed.ncbi.nlm.nih.gov/30354298" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9UH92-1", "protein_name": "Max-like protein X", "gene_name": "MLX", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9UH92", "url": "https://www.uniprot.org/uniprotkb/Q9UH92" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.30354298", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "MLX plays a key role in lipid and glucose metabolism in humans: Evidence from in vitro and in vivo studies.", "journal": "Metabolism: clinical and experimental", "date": "2023-07", "authors": "Nagarajan Shilpa R, Livingstone Eilidh J, Monfeuga Thomas, Lewis Lara C, Ali Shahul Hameed Liyakath, Chandran Anandhakumar, Dearlove David J, Neville Matt J, Chen Lingyan, Maroteau Cyrielle, Ruby Maxwell A, Hodson Leanne", "reference": { "type": "PubMed", "id": "37088121", "url": "https://pubmed.ncbi.nlm.nih.gov/37088121" }, "referenced_glycans": [], "referenced_proteins": [ { 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"count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1.", "journal": "Genes & development", "date": "2001", "authors": "Tao W, Pennica D, Xu L, Kalejta RF, Levine AJ", "reference": { "type": "PubMed", "id": "11459829", "url": "https://pubmed.ncbi.nlm.nih.gov/11459829" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O00308-1", "protein_name": "NEDD4-like E3 ubiquitin-protein ligase WWP2", "gene_name": "WWP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75044-1", "protein_name": "SLIT-ROBO Rho GTPase-activating protein 2", "gene_name": "SRGAP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46940-1", "protein_name": "Ras GTPase-activating-like protein IQGAP1", "gene_name": "IQGAP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13153-1", "protein_name": 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2-beta", "gene_name": "PTK2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27986-1", "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit alpha", "gene_name": "PIK3R1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12931-1", "protein_name": "Proto-oncogene tyrosine-protein kinase Src", "gene_name": "SRC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P16333-1", "protein_name": "SH2/SH3 adapter protein NCK1", "gene_name": "NCK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14964-1", "protein_name": "Hepatocyte growth factor-regulated tyrosine kinase substrate", "gene_name": "HGS", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43639-1", "protein_name": "Cytoplasmic protein NCK2", "gene_name": "NCK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75886-1", "protein_name": "Signal transducing adapter molecule 2", "gene_name": "STAM2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NPB6-1", "protein_name": "Partitioning defective 6 homolog alpha", "gene_name": "PARD6A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O00308", "url": "https://www.uniprot.org/uniprotkb/O00308" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 107, "end_pos": 107, "sequence_org": "Q", "sequence_mut": "L", "comment": "Constitutively active. Results in increased rates of stress fiber dissolution and cell migration. No effect on ARHGAP30-binding.", "evidence": [ { "database": "UniProtKB", "id": "Q7L0Q8", "url": "https://www.uniprot.org/uniprotkb/Q7L0Q8" }, { "database": "PubMed", "id": "21565175", "url": "https://pubmed.ncbi.nlm.nih.gov/21565175" }, { "database": "PubMed", "id": "11459829", "url": "https://pubmed.ncbi.nlm.nih.gov/11459829" }, { "database": "PubMed", "id": "17620058", "url": "https://pubmed.ncbi.nlm.nih.gov/17620058" } ], "uniprot_canonical_ac": "Q7L0Q8-1" }, { "start_pos": 63, "end_pos": 63, "sequence_org": "T", "sequence_mut": "N", "comment": "Loss of GTP-binding and localization to focal adhesions. No effect on ARHGAP30-binding.", "evidence": [ { "database": "UniProtKB", "id": "Q7L0Q8", "url": "https://www.uniprot.org/uniprotkb/Q7L0Q8" }, { "database": "PubMed", "id": "21565175", "url": "https://pubmed.ncbi.nlm.nih.gov/21565175" }, { "database": "PubMed", "id": "11459829", "url": "https://pubmed.ncbi.nlm.nih.gov/11459829" }, { "database": "PubMed", "id": "17620058", "url": "https://pubmed.ncbi.nlm.nih.gov/17620058" } ], "uniprot_canonical_ac": "Q7L0Q8-1" } ], "record_id": "pubmed.11459829", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 40 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein.", "journal": "J. Biol. Chem.", "date": "2002", "authors": "Harvey KF, Shearwin-Whyatt LM, Fotia A, Parton RG, Kumar S", "reference": { "type": "PubMed", "id": "11748237", "url": "https://pubmed.ncbi.nlm.nih.gov/11748237" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O00308-1", "protein_name": "NEDD4-like E3 ubiquitin-protein ligase WWP2", "gene_name": "WWP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8C863-1", "protein_name": "E3 ubiquitin-protein ligase Itchy", "gene_name": "Itch", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q8R0W6-1", "protein_name": "NEDD4 family-interacting protein 1", "gene_name": "Ndfip1", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q96PU5-1", "protein_name": "E3 ubiquitin-protein ligase NEDD4-like", "gene_name": "NEDD4L", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BT67-1", "protein_name": "NEDD4 family-interacting protein 1", "gene_name": "NDFIP1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O00308", "url": "https://www.uniprot.org/uniprotkb/O00308" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11748237", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 5 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", 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"Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases.", "journal": "Biochemistry", "date": "2002", "authors": "Galinier Richard, Gout Evelyne, Lortat-Jacob Hugues, Wood Jonathan, Chroboczek Jadwiga", "reference": { "type": "PubMed", "id": "12450395", "url": "https://pubmed.ncbi.nlm.nih.gov/12450395" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O00308-1", "protein_name": "NEDD4-like E3 ubiquitin-protein ligase WWP2", "gene_name": "WWP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H0M0-1", "protein_name": "NEDD4-like E3 ubiquitin-protein ligase WWP1", "gene_name": "WWP1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O00308", "url": "https://www.uniprot.org/uniprotkb/O00308" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.12450395", "abstract": "", 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"n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Wrch1 is a GTPase-deficient Cdc42-like protein with unusual binding characteristics and cellular effects.", "journal": "Experimental cell research", "date": "2004", "authors": "Saras J, Wollberg P, Aspenstrom P", "reference": { "type": "PubMed", 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"O96013-1", "protein_name": "Serine/threonine-protein kinase PAK 4", "gene_name": "PAK4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13813-1", "protein_name": "Spectrin alpha chain, non-erythrocytic 1", "gene_name": "SPTAN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7L0Q8-1", "protein_name": "Rho-related GTP-binding protein RhoU", "gene_name": "RHOU", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14289-1", "protein_name": "Protein-tyrosine kinase 2-beta", "gene_name": "PTK2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27986-1", "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit alpha", "gene_name": "PIK3R1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12931-1", "protein_name": "Proto-oncogene tyrosine-protein kinase Src", "gene_name": "SRC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P16333-1", "protein_name": "SH2/SH3 adapter protein NCK1", "gene_name": "NCK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14964-1", "protein_name": "Hepatocyte growth factor-regulated tyrosine kinase substrate", "gene_name": "HGS", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43639-1", "protein_name": "Cytoplasmic protein NCK2", "gene_name": "NCK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75886-1", "protein_name": "Signal transducing adapter molecule 2", "gene_name": "STAM2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NPB6-1", "protein_name": "Partitioning defective 6 homolog alpha", "gene_name": "PARD6A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O00308", "url": "https://www.uniprot.org/uniprotkb/O00308" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.15350535", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 39 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase.", "journal": "Current biology : CB", "date": "2004", "authors": "Shutes A, Berzat AC, Cox AD, Der CJ", "reference": { "type": "PubMed", "id": "15556869", "url": "https://pubmed.ncbi.nlm.nih.gov/15556869" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O00308-1", "protein_name": "NEDD4-like E3 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"uniprot_canonical_ac": "O75914-1", "protein_name": "Serine/threonine-protein kinase PAK 3", "gene_name": "PAK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P29317-1", "protein_name": "Ephrin type-A receptor 2", "gene_name": "EPHA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UM54-3", "protein_name": "Unconventional myosin-VI", "gene_name": "MYO6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NZM3-1", "protein_name": "Intersectin-2", "gene_name": "ITSN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00610-1", "protein_name": "Clathrin heavy chain 1", "gene_name": "CLTC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P60953-2", "protein_name": "Cell division control protein 42 homolog", "gene_name": "CDC42", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14155-4", "protein_name": "Rho guanine nucleotide exchange factor 7", "gene_name": "ARHGEF7", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00459-1", "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit beta", "gene_name": "PIK3R2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14161-1", "protein_name": "ARF GTPase-activating protein GIT2", "gene_name": "GIT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NNW5-1", "protein_name": "tRNA (34-2'-O)-methyltransferase regulator WDR6", "gene_name": "WDR6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7Z6I6-1", "protein_name": "Rho GTPase-activating protein 30", "gene_name": "ARHGAP30", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q93008-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 9X", "gene_name": "USP9X", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43396-1", "protein_name": "Thioredoxin-like protein 1", "gene_name": "TXNL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O96013-1", "protein_name": "Serine/threonine-protein kinase PAK 4", "gene_name": "PAK4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13813-1", "protein_name": "Spectrin alpha chain, 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protein NCK2", "gene_name": "NCK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75886-1", "protein_name": "Signal transducing adapter molecule 2", "gene_name": "STAM2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NPB6-1", "protein_name": "Partitioning defective 6 homolog alpha", "gene_name": "PARD6A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O00308", "url": "https://www.uniprot.org/uniprotkb/O00308" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.15556869", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 39 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The atypical Rho family GTPase Wrch-1 regulates focal adhesion formation and cell migration.", "journal": "Journal of cell science", "date": "2007", "authors": "Chuang YY, Valster A, Coniglio SJ, Backer JM, Symons M", "reference": { "type": "PubMed", "id": "17504809", "url": "https://pubmed.ncbi.nlm.nih.gov/17504809" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O00308-1", "protein_name": "NEDD4-like E3 ubiquitin-protein ligase WWP2", "gene_name": "WWP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75044-1", "protein_name": "SLIT-ROBO Rho 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molecule 1", "gene_name": "STAM", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q2M1Z3-1", "protein_name": "Rho GTPase-activating protein 31", "gene_name": "ARHGAP31", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H792-1", "protein_name": "Inactive tyrosine-protein kinase PEAK1", "gene_name": "PEAK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q03001-7", "protein_name": "Dystonin", "gene_name": "DST", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8TDM6-1", "protein_name": "Disks large homolog 5", "gene_name": "DLG5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8TAA9-1", "protein_name": "Vang-like protein 1", "gene_name": "VANGL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q01082-1", "protein_name": "Spectrin beta chain, non-erythrocytic 1", "gene_name": "SPTBN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75914-1", "protein_name": "Serine/threonine-protein kinase PAK 3", "gene_name": "PAK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P29317-1", "protein_name": "Ephrin type-A receptor 2", "gene_name": "EPHA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UM54-3", "protein_name": "Unconventional myosin-VI", "gene_name": "MYO6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NZM3-1", "protein_name": "Intersectin-2", "gene_name": "ITSN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00610-1", "protein_name": "Clathrin heavy chain 1", "gene_name": "CLTC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P60953-2", "protein_name": "Cell division control protein 42 homolog", "gene_name": "CDC42", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14155-4", "protein_name": "Rho guanine nucleotide exchange factor 7", "gene_name": "ARHGEF7", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00459-1", "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit beta", "gene_name": "PIK3R2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14161-1", "protein_name": "ARF GTPase-activating protein 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"tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NPB6-1", "protein_name": "Partitioning defective 6 homolog alpha", "gene_name": "PARD6A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O00308", "url": "https://www.uniprot.org/uniprotkb/O00308" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.17504809", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 39 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { 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"ARHGAP31", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H792-1", "protein_name": "Inactive tyrosine-protein kinase PEAK1", "gene_name": "PEAK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q03001-7", "protein_name": "Dystonin", "gene_name": "DST", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8TDM6-1", "protein_name": "Disks large homolog 5", "gene_name": "DLG5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8TAA9-1", "protein_name": "Vang-like protein 1", "gene_name": "VANGL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q01082-1", "protein_name": "Spectrin beta chain, non-erythrocytic 1", "gene_name": "SPTBN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75914-1", "protein_name": "Serine/threonine-protein kinase PAK 3", "gene_name": "PAK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P29317-1", "protein_name": "Ephrin type-A receptor 2", "gene_name": "EPHA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UM54-3", "protein_name": 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"gene_name": "WDR6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7Z6I6-1", "protein_name": "Rho GTPase-activating protein 30", "gene_name": "ARHGAP30", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q93008-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 9X", "gene_name": "USP9X", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43396-1", "protein_name": "Thioredoxin-like protein 1", "gene_name": "TXNL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O96013-1", "protein_name": "Serine/threonine-protein kinase PAK 4", "gene_name": "PAK4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13813-1", "protein_name": "Spectrin alpha chain, non-erythrocytic 1", "gene_name": "SPTAN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7L0Q8-1", "protein_name": "Rho-related GTP-binding protein RhoU", "gene_name": "RHOU", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14289-1", "protein_name": "Protein-tyrosine kinase 2-beta", "gene_name": "PTK2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27986-1", "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit alpha", "gene_name": "PIK3R1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12931-1", "protein_name": "Proto-oncogene tyrosine-protein kinase Src", "gene_name": "SRC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P16333-1", "protein_name": "SH2/SH3 adapter protein NCK1", "gene_name": "NCK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14964-1", "protein_name": "Hepatocyte growth factor-regulated tyrosine kinase substrate", "gene_name": "HGS", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43639-1", "protein_name": "Cytoplasmic protein NCK2", "gene_name": "NCK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75886-1", "protein_name": "Signal transducing adapter molecule 2", "gene_name": "STAM2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NPB6-1", "protein_name": "Partitioning defective 6 homolog alpha", "gene_name": "PARD6A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O00308", "url": "https://www.uniprot.org/uniprotkb/O00308" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.19064640", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 39 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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"count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells.", "journal": "Cell research", "date": "2009", "authors": "Xu H, Wang W, Li C, Yu H, Yang A, Wang B, Jin Y", "reference": { "type": "PubMed", "id": "19274063", "url": "https://pubmed.ncbi.nlm.nih.gov/19274063" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O00308-1", "protein_name": "NEDD4-like E3 ubiquitin-protein ligase WWP2", "gene_name": "WWP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q01860-1", "protein_name": "POU domain, class 5, transcription factor 1", "gene_name": "POU5F1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O00308", "url": "https://www.uniprot.org/uniprotkb/O00308" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 838, "end_pos": 838, "sequence_org": "C", "sequence_mut": "A", "comment": "Abolishes ubiquitination of POU5F1.", "evidence": [ { "database": "UniProtKB", "id": "O00308", "url": "https://www.uniprot.org/uniprotkb/O00308" }, { "database": "PubMed", "id": "19274063", "url": "https://pubmed.ncbi.nlm.nih.gov/19274063" } ], "uniprot_canonical_ac": "O00308-1" } ], "record_id": "pubmed.19274063", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins.", "journal": "EMBO reports", "date": "2009", "authors": "Mund T, Pelham HR", "reference": { "type": "PubMed", "id": "19343052", "url": "https://pubmed.ncbi.nlm.nih.gov/19343052" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O00308-1", "protein_name": "NEDD4-like E3 ubiquitin-protein ligase WWP2", "gene_name": "WWP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H0M0-1", "protein_name": "NEDD4-like E3 ubiquitin-protein ligase WWP1", "gene_name": "WWP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HAU4-1", "protein_name": "E3 ubiquitin-protein ligase SMURF2", "gene_name": "SMURF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96PU5-1", "protein_name": "E3 ubiquitin-protein ligase NEDD4-like", "gene_name": 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"count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Regulation of the Rho family small GTPase Wrch-1/RhoU by C-terminal tyrosine phosphorylation requires Src.", "journal": "Molecular and cellular biology", "date": "2010", "authors": "Alan JK, Berzat AC, Dewar BJ, Graves LM, Cox AD", "reference": { "type": "PubMed", "id": "20547754", "url": "https://pubmed.ncbi.nlm.nih.gov/20547754" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O00308-1", "protein_name": "NEDD4-like E3 ubiquitin-protein ligase WWP2", "gene_name": "WWP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75044-1", "protein_name": "SLIT-ROBO Rho GTPase-activating protein 2", "gene_name": "SRGAP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46940-1", "protein_name": "Ras GTPase-activating-like protein IQGAP1", "gene_name": "IQGAP1", "tax_name": "Human" }, { 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"Human" }, { "uniprot_canonical_ac": "Q9NZM3-1", "protein_name": "Intersectin-2", "gene_name": "ITSN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00610-1", "protein_name": "Clathrin heavy chain 1", "gene_name": "CLTC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P60953-2", "protein_name": "Cell division control protein 42 homolog", "gene_name": "CDC42", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14155-4", "protein_name": "Rho guanine nucleotide exchange factor 7", "gene_name": "ARHGEF7", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00459-1", "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit beta", "gene_name": "PIK3R2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14161-1", "protein_name": "ARF GTPase-activating protein GIT2", "gene_name": "GIT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NNW5-1", "protein_name": "tRNA (34-2'-O)-methyltransferase regulator WDR6", "gene_name": "WDR6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7Z6I6-1", "protein_name": "Rho GTPase-activating protein 30", "gene_name": "ARHGAP30", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q93008-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 9X", "gene_name": "USP9X", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43396-1", "protein_name": "Thioredoxin-like protein 1", "gene_name": "TXNL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O96013-1", "protein_name": "Serine/threonine-protein kinase PAK 4", "gene_name": "PAK4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13813-1", "protein_name": "Spectrin alpha chain, non-erythrocytic 1", "gene_name": "SPTAN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7L0Q8-1", "protein_name": "Rho-related GTP-binding protein RhoU", "gene_name": "RHOU", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14289-1", "protein_name": "Protein-tyrosine kinase 2-beta", "gene_name": "PTK2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27986-1", "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit alpha", "gene_name": "PIK3R1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12931-1", "protein_name": "Proto-oncogene tyrosine-protein kinase Src", "gene_name": "SRC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P16333-1", "protein_name": "SH2/SH3 adapter protein NCK1", "gene_name": "NCK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14964-1", "protein_name": "Hepatocyte growth factor-regulated tyrosine kinase substrate", "gene_name": "HGS", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43639-1", "protein_name": "Cytoplasmic protein NCK2", "gene_name": "NCK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75886-1", "protein_name": "Signal transducing adapter molecule 2", "gene_name": "STAM2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NPB6-1", "protein_name": "Partitioning defective 6 homolog alpha", "gene_name": "PARD6A", "tax_name": "Human" } ], "species": [ { "name": "Homo 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"title": "Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways.", "journal": "Mol. Cancer Res.", "date": "2010", "authors": "Gilmore-Hebert M, Ramabhadran R, Stern DF", "reference": { "type": "PubMed", "id": "20858735", "url": "https://pubmed.ncbi.nlm.nih.gov/20858735" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O00308-1", "protein_name": "NEDD4-like E3 ubiquitin-protein ligase WWP2", "gene_name": "WWP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P83876-1", "protein_name": "Thioredoxin-like protein 4A", "gene_name": "TXNL4A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15029-1", "protein_name": "116 kDa U5 small nuclear ribonucleoprotein component", "gene_name": "EFTUD2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00839-1", "protein_name": "Heterogeneous nuclear ribonucleoprotein U", "gene_name": "HNRNPU", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96J02-1", "protein_name": "E3 ubiquitin-protein ligase Itchy homolog", "gene_name": "ITCH", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13263-1", "protein_name": "Transcription intermediary factor 1-beta", "gene_name": "TRIM28", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19338-1", "protein_name": "Nucleolin", "gene_name": "NCL", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BUQ8-1", "protein_name": "Probable ATP-dependent RNA helicase DDX23", "gene_name": "DDX23", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BXP5-1", "protein_name": "Serrate RNA effector molecule homolog", "gene_name": "SRRT", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15042-1", "protein_name": "U2 snRNP-associated SURP motif-containing protein", "gene_name": "U2SURP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15303-1", "protein_name": "Receptor tyrosine-protein kinase erbB-4", "gene_name": "ERBB4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00987-1", "protein_name": "E3 ubiquitin-protein ligase Mdm2", "gene_name": "MDM2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O00308", "url": "https://www.uniprot.org/uniprotkb/O00308" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.20858735", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 12 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": 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"count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Multiple interactions between the ESCRT machinery and arrestin-related proteins: implications for PPXY-dependent budding.", "journal": "J. Virol.", "date": "2011", "authors": "Rauch S, Martin-Serrano J", "reference": { "type": "PubMed", "id": "21191027", "url": "https://pubmed.ncbi.nlm.nih.gov/21191027" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O00308-1", "protein_name": "NEDD4-like E3 ubiquitin-protein ligase WWP2", "gene_name": "WWP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46934-1", "protein_name": "E3 ubiquitin-protein ligase NEDD4", "gene_name": "NEDD4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N5I2-1", "protein_name": "Arrestin domain-containing protein 1", "gene_name": "ARRDC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8TBH0-1", "protein_name": "Arrestin domain-containing protein 2", "gene_name": "ARRDC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99816-1", "protein_name": "Tumor susceptibility gene 101 protein", "gene_name": "TSG101", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96J02-1", "protein_name": "E3 ubiquitin-protein ligase Itchy homolog", "gene_name": "ITCH", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WUM4-1", "protein_name": "Programmed cell death 6-interacting protein", "gene_name": "PDCD6IP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96B67-1", "protein_name": "Arrestin domain-containing protein 3", "gene_name": "ARRDC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H0M0-1", "protein_name": "NEDD4-like E3 ubiquitin-protein ligase WWP1", "gene_name": "WWP1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O00308", "url": "https://www.uniprot.org/uniprotkb/O00308" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.21191027", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 9 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { 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"count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "GRB2 couples RhoU to epidermal growth factor receptor signaling and cell migration.", "journal": "Molecular biology of the cell", "date": "2011", "authors": "Zhang JS, Koenig A, Young C, Billadeau DD", "reference": { "type": "PubMed", "id": "21508312", "url": "https://pubmed.ncbi.nlm.nih.gov/21508312" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O00308-1", "protein_name": "NEDD4-like E3 ubiquitin-protein ligase WWP2", "gene_name": "WWP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75044-1", "protein_name": "SLIT-ROBO Rho GTPase-activating protein 2", "gene_name": "SRGAP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46940-1", "protein_name": "Ras GTPase-activating-like protein IQGAP1", "gene_name": "IQGAP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13153-1", 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"Q9NZM3-1", "protein_name": "Intersectin-2", "gene_name": "ITSN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00610-1", "protein_name": "Clathrin heavy chain 1", "gene_name": "CLTC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P60953-2", "protein_name": "Cell division control protein 42 homolog", "gene_name": "CDC42", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14155-4", "protein_name": "Rho guanine nucleotide exchange factor 7", "gene_name": "ARHGEF7", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00459-1", "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit beta", "gene_name": "PIK3R2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14161-1", "protein_name": "ARF GTPase-activating protein GIT2", "gene_name": "GIT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NNW5-1", "protein_name": "tRNA (34-2'-O)-methyltransferase regulator WDR6", "gene_name": "WDR6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7Z6I6-1", "protein_name": "Rho GTPase-activating protein 30", "gene_name": "ARHGAP30", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q93008-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 9X", "gene_name": "USP9X", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43396-1", "protein_name": "Thioredoxin-like protein 1", "gene_name": "TXNL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O96013-1", "protein_name": "Serine/threonine-protein kinase PAK 4", "gene_name": "PAK4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13813-1", "protein_name": "Spectrin alpha chain, non-erythrocytic 1", "gene_name": "SPTAN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7L0Q8-1", "protein_name": "Rho-related GTP-binding protein RhoU", "gene_name": "RHOU", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14289-1", "protein_name": "Protein-tyrosine kinase 2-beta", "gene_name": "PTK2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27986-1", "protein_name": "Phosphatidylinositol 3-kinase 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regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.", "journal": "The EMBO journal", "date": "2011", "authors": "Cui Y, He S, Xing C, Lu K, Wang J, Xing G, Meng A, Jia S, He F, Zhang L", "reference": { "type": "PubMed", "id": "21572392", "url": "https://pubmed.ncbi.nlm.nih.gov/21572392" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O00308-1", "protein_name": "NEDD4-like E3 ubiquitin-protein ligase WWP2", "gene_name": "WWP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "D4ABB4-1", "protein_name": "F-box/LRR-repeat protein 15", "gene_name": "Fbxl15", "tax_name": "Rat" }, { "uniprot_canonical_ac": "Q9HCE7-1", "protein_name": "E3 ubiquitin-protein ligase SMURF1", "gene_name": "SMURF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H469-1", "protein_name": "F-box/LRR-repeat protein 15", "gene_name": "FBXL15", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HAU4-1", "protein_name": "E3 ubiquitin-protein 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"start_pos": 500, "end_pos": 500, "sequence_org": "H", "sequence_mut": "K", "comment": "Does not affect FBXL15-mediated ubiquitination.", "evidence": [ { "database": "UniProtKB", "id": "O00308", "url": "https://www.uniprot.org/uniprotkb/O00308" }, { "database": "PubMed", "id": "21572392", "url": "https://pubmed.ncbi.nlm.nih.gov/21572392" } ], "uniprot_canonical_ac": "O00308-1" }, { "start_pos": 350, "end_pos": 350, "sequence_org": "K", "sequence_mut": "R", "comment": "Abolishes FBXL15-mediated ubiquitination and degradation; when associated with R-381 and R-381.", "evidence": [ { "database": "UniProtKB", "id": "Q9HCE7", "url": "https://www.uniprot.org/uniprotkb/Q9HCE7" }, { "database": "PubMed", "id": "21572392", "url": "https://pubmed.ncbi.nlm.nih.gov/21572392" } ], "uniprot_canonical_ac": "Q9HCE7-1" }, { "start_pos": 381, "end_pos": 381, "sequence_org": "K", "sequence_mut": "R", "comment": "Abolishes FBXL15-mediated ubiquitination and degradation; when associated with R-350 and 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Abolishes FBXL15-mediated ubiquitination and degradation; when associated with R-381.", "evidence": [ { "database": "UniProtKB", "id": "Q9HCE7", "url": "https://www.uniprot.org/uniprotkb/Q9HCE7" }, { "database": "PubMed", "id": "21572392", "url": "https://pubmed.ncbi.nlm.nih.gov/21572392" } ], "uniprot_canonical_ac": "Q9HCE7-1" }, { "start_pos": 725, "end_pos": 725, "sequence_org": "C", "sequence_mut": "A", "comment": "Loss of enzyme activity, without abolishing FBXL15-mediated ubiquitination.", "evidence": [ { "database": "UniProtKB", "id": "Q9HCE7", "url": "https://www.uniprot.org/uniprotkb/Q9HCE7" }, { "database": "PubMed", "id": "19937093", "url": "https://pubmed.ncbi.nlm.nih.gov/19937093" }, { "database": "PubMed", "id": "21572392", "url": "https://pubmed.ncbi.nlm.nih.gov/21572392" } ], "uniprot_canonical_ac": "Q9HCE7-1" } ], "record_id": "pubmed.21572392", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 7 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2012", "authors": "Nabhan JF, Hu R, Oh RS, Cohen SN, Lu Q", "reference": { "type": "PubMed", "id": "22315426", "url": "https://pubmed.ncbi.nlm.nih.gov/22315426" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O00308-1", "protein_name": "NEDD4-like E3 ubiquitin-protein ligase WWP2", "gene_name": "WWP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N5I2-1", "protein_name": "Arrestin domain-containing protein 1", "gene_name": "ARRDC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99816-1", "protein_name": "Tumor susceptibility gene 101 protein", "gene_name": "TSG101", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O00308", "url": "https://www.uniprot.org/uniprotkb/O00308" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 180, "end_pos": 180, "sequence_org": "G", "sequence_mut": "A", "comment": "Decreased localization to the cell membrane and extracellular vesicles.", "evidence": [ { "database": "UniProtKB", "id": "Q8N5I2", "url": "https://www.uniprot.org/uniprotkb/Q8N5I2" }, { "database": "PubMed", "id": "22315426", "url": "https://pubmed.ncbi.nlm.nih.gov/22315426" } ], "uniprot_canonical_ac": "Q8N5I2-1" }, { "start_pos": 191, "end_pos": 191, "sequence_org": "N", "sequence_mut": "D", "comment": "Decreased localization to the cell membrane and extracellular vesicles.", "evidence": [ { "database": "UniProtKB", "id": "Q8N5I2", "url": "https://www.uniprot.org/uniprotkb/Q8N5I2" }, { "database": "PubMed", "id": "22315426", "url": "https://pubmed.ncbi.nlm.nih.gov/22315426" } ], "uniprot_canonical_ac": "Q8N5I2-1" }, { "start_pos": 310, "end_pos": 310, "sequence_org": "S", "sequence_mut": "A", "comment": "Decreased interaction with TSG101. 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"NEDD4-like E3 ubiquitin-protein ligase WWP2", "gene_name": "WWP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96J02-1", "protein_name": "E3 ubiquitin-protein ligase Itchy homolog", "gene_name": "ITCH", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30518-1", "protein_name": "Vasopressin V2 receptor", "gene_name": "AVPR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NCT1-1", "protein_name": "Arrestin domain-containing protein 4", "gene_name": "ARRDC4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96PU5-1", "protein_name": "E3 ubiquitin-protein ligase NEDD4-like", "gene_name": "NEDD4L", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14964-1", "protein_name": "Hepatocyte growth factor-regulated tyrosine kinase substrate", "gene_name": "HGS", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O00308", "url": "https://www.uniprot.org/uniprotkb/O00308" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.23236378", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 6 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Structure of the HECT domain of human WWP2.", "journal": "Acta Crystallogr. F", "date": "2015", "authors": "Gong Wei, Zhang Xiaodan, Zhang Wen, Li Jie, Li Ze", "reference": { "type": "PubMed", "id": "26457515", "url": "https://pubmed.ncbi.nlm.nih.gov/26457515" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O00308-1", "protein_name": "NEDD4-like E3 ubiquitin-protein ligase WWP2", "gene_name": "WWP2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O00308", "url": "https://www.uniprot.org/uniprotkb/O00308" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.26457515", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": 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"glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The atypical Rho GTPase RhoU interacts with intersectin-2 to regulate endosomal recycling pathways.", "journal": "Journal of cell science", "date": "2020", "authors": "Gubar O, Croise P, Kropyvko S, Gryaznova T, Toth P, Blangy A, Vitale N, Rynditch A, Gasman S, Ory S", "reference": { "type": "PubMed", "id": "32737221", "url": "https://pubmed.ncbi.nlm.nih.gov/32737221" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O00308-1", "protein_name": "NEDD4-like E3 ubiquitin-protein ligase WWP2", "gene_name": "WWP2", 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"Human" }, { "uniprot_canonical_ac": "Q92783-1", "protein_name": "Signal transducing adapter molecule 1", "gene_name": "STAM", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q2M1Z3-1", "protein_name": "Rho GTPase-activating protein 31", "gene_name": "ARHGAP31", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H792-1", "protein_name": "Inactive tyrosine-protein kinase PEAK1", "gene_name": "PEAK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q03001-7", "protein_name": "Dystonin", "gene_name": "DST", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8TDM6-1", "protein_name": "Disks large homolog 5", "gene_name": "DLG5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8TAA9-1", "protein_name": "Vang-like protein 1", "gene_name": "VANGL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q01082-1", "protein_name": "Spectrin beta chain, non-erythrocytic 1", "gene_name": "SPTBN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75914-1", "protein_name": "Serine/threonine-protein kinase PAK 3", "gene_name": "PAK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P29317-1", "protein_name": "Ephrin type-A receptor 2", "gene_name": "EPHA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UM54-3", "protein_name": "Unconventional myosin-VI", "gene_name": "MYO6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NZM3-1", "protein_name": "Intersectin-2", "gene_name": "ITSN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00610-1", "protein_name": "Clathrin heavy chain 1", "gene_name": "CLTC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P60953-2", "protein_name": "Cell division control protein 42 homolog", "gene_name": "CDC42", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14155-4", "protein_name": "Rho guanine nucleotide exchange factor 7", "gene_name": "ARHGEF7", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00459-1", "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit beta", "gene_name": "PIK3R2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14161-1", "protein_name": "ARF GTPase-activating protein GIT2", "gene_name": "GIT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NNW5-1", "protein_name": "tRNA (34-2'-O)-methyltransferase regulator WDR6", "gene_name": "WDR6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7Z6I6-1", "protein_name": "Rho GTPase-activating protein 30", "gene_name": "ARHGAP30", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q93008-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 9X", "gene_name": "USP9X", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43396-1", "protein_name": "Thioredoxin-like protein 1", "gene_name": "TXNL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O96013-1", "protein_name": "Serine/threonine-protein kinase PAK 4", "gene_name": "PAK4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13813-1", "protein_name": "Spectrin alpha chain, non-erythrocytic 1", "gene_name": "SPTAN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7L0Q8-1", "protein_name": "Rho-related GTP-binding protein RhoU", "gene_name": "RHOU", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14289-1", "protein_name": "Protein-tyrosine kinase 2-beta", "gene_name": "PTK2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27986-1", "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit alpha", "gene_name": "PIK3R1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12931-1", "protein_name": "Proto-oncogene tyrosine-protein kinase Src", "gene_name": "SRC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P16333-1", "protein_name": "SH2/SH3 adapter protein NCK1", "gene_name": "NCK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14964-1", "protein_name": "Hepatocyte growth factor-regulated tyrosine kinase substrate", "gene_name": "HGS", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43639-1", "protein_name": "Cytoplasmic protein NCK2", "gene_name": "NCK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75886-1", "protein_name": "Signal transducing adapter molecule 2", "gene_name": "STAM2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NPB6-1", "protein_name": "Partitioning defective 6 homolog alpha", "gene_name": "PARD6A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O00308", "url": "https://www.uniprot.org/uniprotkb/O00308" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.32737221", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 39 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { 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"table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Enzymatic analysis of WWP2 E3 ubiquitin ligase using protein microarrays identifies autophagy-related substrates.", "journal": "The Journal of biological chemistry", "date": "2022", "authors": "Jiang H, Chiang CY, Chen Z, Nathan S, D'Agostino G, Paulo JA, Song G, Zhu H, Gabelli SB, Cole PA", "reference": { "type": "PubMed", "id": "35331737", "url": "https://pubmed.ncbi.nlm.nih.gov/35331737" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O00308-1", "protein_name": "NEDD4-like E3 ubiquitin-protein ligase WWP2", "gene_name": "WWP2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O00308", "url": "https://www.uniprot.org/uniprotkb/O00308" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "phosphorylation": [ { "start_pos": 369, "end_pos": 369, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O00308", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00308" }, { "database": "PubMed", "id": "35331737", "url": "https://pubmed.ncbi.nlm.nih.gov/35331737" } ], "site_lbl": "Tyr369", "uniprot_canonical_ac": "O00308-1" } ], "record_id": "pubmed.35331737", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", 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"field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] } ]