[
    {
        "title": "vtRNA2-1/nc886 Produces a Small RNA That Contributes to Its Tumor Suppression Action through the microRNA Pathway in Prostate Cancer.",
        "journal": "Non-coding RNA",
        "date": "2020-02-20",
        "authors": "Fort Rafael Sebasti\u00e1n, Garat Beatriz, Sotelo-Silveira Jos\u00e9 Roberto, Duhagon Mar\u00eda Ana",
        "reference": {
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    {
        "title": "PKR kinase directly regulates tau expression and Alzheimer's disease-related tau phosphorylation.",
        "journal": "Brain pathology (Zurich, Switzerland)",
        "date": "2021-01",
        "authors": "Reimer Lasse, Betzer Cristine, Kofoed Rikke Hahn, Volbracht Christiane, Fog Karina, Kurhade Chaitanya, Nilsson Emma, \u00d6verby Anna K, Jensen Poul Henning",
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    {
        "title": "Cell fate determined by the activation balance between PKR and SPHK1.",
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        "date": "2021-01",
        "authors": "Qiao Han, Jiang Tianqing, Mu Peiqiang, Chen Xiaoxuan, Wen Xianhui, Hu Zhangsheng, Tang Shulin, Wen Jikai, Deng Yiqun",
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        "title": "Regulation of PKR activation and apoptosis during oxidative stress by TRBP phosphorylation.",
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        "date": "2022-02",
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    {
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        "authors": "Kim Sujin, Lee Keonyong, Choi Yong Seok, Ku Jayoung, Kim Hyeonkyeong, Kharbash Raisa, Yoon Jimin, Lee Yong Seuk, Kim Jin-Hong, Lee Yun Jong, Kim Yoosik",
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        "title": "Protein kinase R dependent phosphorylation of \u03b1-synuclein regulates its membrane binding and aggregation.",
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        "authors": "Reimer Lasse, Gram Hjalte, Jensen Nanna M\u00f8ller, Betzer Cristine, Yang Li, Jin Lorrain, Shi Min, Boudeffa Driss, Fusco Giuliana, De Simone Alfonso, Kirik Deniz, Lashuel Hilal A, Zhang Jing, Jensen Poul Henning",
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    {
        "title": "PACT inhibits the replication of SARS-CoV-2 through the blockage of GSK-3\u03b2-N-nsp3 cascade.",
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        "title": "Nuclear localization of the interferon-inducible protein kinase PKR in human cells and transfected mouse cells.",
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    {
        "title": "Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2.",
        "journal": "Molecular and cellular biology",
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    {
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        "authors": "Harty RN, Brown ME, Wang G, Huibregtse J, Hayes FP",
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        "title": "Ubiquitination of HIV-1 and MuLV Gag.",
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        "date": "2000",
        "authors": "Ott DE, Coren LV, Chertova EN, Gagliardi TD, Schubert U",
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        "title": "Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein.",
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    {
        "title": "The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein.",
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        "title": "Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation.",
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        "date": "2004",
        "authors": "Kim KI, Giannakopoulos NV, Virgin HW, Zhang DE",
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    {
        "title": "An unconventional NLS is critical for the nuclear import of the influenza A virus nucleoprotein and ribonucleoprotein.",
        "journal": "Traffic (Copenhagen, Denmark)",
        "date": "2005",
        "authors": "Cros JF, Garcia-Sastre A, Palese P",
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        "title": "Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.",
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                "protein_name": "E3 ubiquitin-protein ligase NEDD4",
                "gene_name": "NEDD4",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9Y6K5-1",
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                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P78344-1",
                "protein_name": "Eukaryotic translation initiation factor 4 gamma 2",
                "gene_name": "EIF4G2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q02556-1",
                "protein_name": "Interferon regulatory factor 8",
                "gene_name": "IRF8",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q96AZ6-1",
                "protein_name": "Interferon-stimulated gene 20 kDa protein",
                "gene_name": "ISG20",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "O14896-1",
                "protein_name": "Interferon regulatory factor 6",
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                "tax_name": "Human"
            },
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                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P30511-1",
                "protein_name": "HLA class I histocompatibility antigen, alpha chain F",
                "gene_name": "HLA-F",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P13747-1",
                "protein_name": "HLA class I histocompatibility antigen, alpha chain E",
                "gene_name": "HLA-E",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P17693-1",
                "protein_name": "HLA class I histocompatibility antigen, alpha chain G",
                "gene_name": "HLA-G",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P60842-1",
                "protein_name": "Eukaryotic initiation factor 4A-I",
                "gene_name": "EIF4A1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O15504-1",
                "protein_name": "Nucleoporin NUP42",
                "gene_name": "NUP42",
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            },
            {
                "uniprot_canonical_ac": "P01563-1",
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                "gene_name": "IFNA2",
                "tax_name": "Human"
            },
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                "protein_name": "Interferon alpha-7",
                "gene_name": "IFNA7",
                "tax_name": "Human"
            },
            {
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                "protein_name": "Interferon alpha-21",
                "gene_name": "IFNA21",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P01569-1",
                "protein_name": "Interferon alpha-5",
                "gene_name": "IFNA5",
                "tax_name": "Human"
            },
            {
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                "protein_name": "Interferon alpha-14",
                "gene_name": "IFNA14",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P09914-1",
                "protein_name": "Antiviral innate immune response effector IFIT1",
                "gene_name": "IFIT1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P32881-1",
                "protein_name": "Interferon alpha-8",
                "gene_name": "IFNA8",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8N5X7-1",
                "protein_name": "Eukaryotic translation initiation factor 4E type 3",
                "gene_name": "EIF4E3",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9UHH9-1",
                "protein_name": "Inositol hexakisphosphate kinase 2",
                "gene_name": "IP6K2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P05013-1",
                "protein_name": "Interferon alpha-6",
                "gene_name": "IFNA6",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9UKX7-1",
                "protein_name": "Nuclear pore complex protein Nup50",
                "gene_name": "NUP50",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P57740-1",
                "protein_name": "Nuclear pore complex protein Nup107",
                "gene_name": "NUP107",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P09913-1",
                "protein_name": "Interferon-induced protein with tetratricopeptide repeats 2",
                "gene_name": "IFIT2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8WUM0-1",
                "protein_name": "Nuclear pore complex protein Nup133",
                "gene_name": "NUP133",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8WXG1-1",
                "protein_name": "S-adenosylmethionine-dependent nucleotide dehydratase RSAD2",
                "gene_name": "RSAD2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9BTX1-1",
                "protein_name": "Nucleoporin NDC1",
                "gene_name": "NDC1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8NFH3-1",
                "protein_name": "Nucleoporin Nup43",
                "gene_name": "NUP43",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8TEM1-1",
                "protein_name": "Nuclear pore membrane glycoprotein 210",
                "gene_name": "NUP210",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P55735-1",
                "protein_name": "Protein SEC13 homolog",
                "gene_name": "SEC13",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O75694-1",
                "protein_name": "Nuclear pore complex protein Nup155",
                "gene_name": "NUP155",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q14258-1",
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                "gene_name": "TRIM25",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P20592-1",
                "protein_name": "Interferon-induced GTP-binding protein Mx2",
                "gene_name": "MX2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P14316-1",
                "protein_name": "Interferon regulatory factor 2",
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                "tax_name": "Human"
            },
            {
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                "protein_name": "Tyrosine-protein phosphatase non-receptor type 6",
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                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "Q14653-1",
                "protein_name": "Interferon regulatory factor 3",
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                "tax_name": "Human"
            },
            {
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                "protein_name": "Interferon-induced GTP-binding protein Mx1",
                "gene_name": "MX1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q13568-1",
                "protein_name": "Interferon regulatory factor 5",
                "gene_name": "IRF5",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P38919-1",
                "protein_name": "Eukaryotic initiation factor 4A-III",
                "gene_name": "EIF4A3",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O14879-1",
                "protein_name": "Interferon-induced protein with tetratricopeptide repeats 3",
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                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O00629-1",
                "protein_name": "Importin subunit alpha-3",
                "gene_name": "KPNA4",
                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "O95786-1",
                "protein_name": "Antiviral innate immune response receptor RIG-I",
                "gene_name": "DDX58; RIGI",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q05823-1",
                "protein_name": "2-5A-dependent ribonuclease",
                "gene_name": "RNASEL",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "Q8NFH5-1",
                "protein_name": "Nucleoporin NUP35",
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                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P10914-1",
                "protein_name": "Interferon regulatory factor 1",
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            },
            {
                "uniprot_canonical_ac": "Q6GPH4-1",
                "protein_name": "XIAP-associated factor 1",
                "gene_name": "XAF1",
                "tax_name": "Human"
            },
            {
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                "protein_name": "Signal transducer and activator of transcription 2",
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            },
            {
                "uniprot_canonical_ac": "O43432-1",
                "protein_name": "Eukaryotic translation initiation factor 4 gamma 3",
                "gene_name": "EIF4G3",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9UMW8-1",
                "protein_name": "Ubl carboxyl-terminal hydrolase 18",
                "gene_name": "USP18",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P41226-1",
                "protein_name": "Ubiquitin-like modifier-activating enzyme 7",
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                "tax_name": "Human"
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                "protein_name": "Interferon alpha-inducible protein 6",
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            },
            {
                "uniprot_canonical_ac": "P10321-1",
                "protein_name": "HLA class I histocompatibility antigen, C alpha chain",
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                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "P04439-1",
                "protein_name": "HLA class I histocompatibility antigen, A alpha chain",
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            },
            {
                "uniprot_canonical_ac": "Q92985-1",
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                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P61221-1",
                "protein_name": "ATP-binding cassette sub-family E member 1",
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            },
            {
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                "protein_name": "Nuclear envelope pore membrane protein POM 121",
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                "protein_name": "Eukaryotic translation initiation factor 4E",
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                "uniprot_canonical_ac": "O60573-1",
                "protein_name": "Eukaryotic translation initiation factor 4E type 2",
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                "uniprot_canonical_ac": "P00973-1",
                "protein_name": "2'-5'-oligoadenylate synthase 1",
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                "protein_name": "Tyrosine-protein phosphatase non-receptor type 11",
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                "protein_name": "Nuclear pore complex protein Nup153",
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            {
                "uniprot_canonical_ac": "Q12769-1",
                "protein_name": "Nuclear pore complex protein Nup160",
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                "protein_name": "Suppressor of cytokine signaling 3",
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                "uniprot_canonical_ac": "P49792-1",
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            {
                "uniprot_canonical_ac": "P62979-1",
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            {
                "uniprot_canonical_ac": "P61088-1",
                "protein_name": "Ubiquitin-conjugating enzyme E2 N",
                "gene_name": "UBE2N",
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            {
                "uniprot_canonical_ac": "P51965-1",
                "protein_name": "Ubiquitin-conjugating enzyme E2 E1",
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                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q10589-1",
                "protein_name": "Bone marrow stromal antigen 2",
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            {
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            {
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                "protein_name": "Double-stranded RNA-specific adenosine deaminase",
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            {
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                "protein_name": "Interferon-induced transmembrane protein 1",
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            {
                "uniprot_canonical_ac": "Q9UII4-1",
                "protein_name": "E3 ISG15--protein ligase HERC5",
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                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P40305-2",
                "protein_name": "Interferon alpha-inducible protein 27, mitochondrial",
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                "tax_name": "Human"
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            {
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                "protein_name": "Interferon-induced transmembrane protein 2",
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            {
                "uniprot_canonical_ac": "P01566-1",
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                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "P01571-1",
                "protein_name": "Interferon alpha-17",
                "gene_name": "IFNA17",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P01574-1",
                "protein_name": "Interferon beta",
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                "tax_name": "Human"
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            {
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                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "Q99567-1",
                "protein_name": "Nuclear pore complex protein Nup88",
                "gene_name": "NUP88",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P28062-1",
                "protein_name": "Proteasome subunit beta type-8",
                "gene_name": "PSMB8",
                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "Q13325-1",
                "protein_name": "Interferon-induced protein with tetratricopeptide repeats 5",
                "gene_name": "IFIT5",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P78406-1",
                "protein_name": "mRNA export factor RAE1",
                "gene_name": "RAE1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8NFH4-1",
                "protein_name": "Nucleoporin Nup37",
                "gene_name": "NUP37",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8N1F7-1",
                "protein_name": "Nuclear pore complex protein Nup93",
                "gene_name": "NUP93",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P19525-1",
                "protein_name": "Interferon-induced, double-stranded RNA-activated protein kinase",
                "gene_name": "EIF2AK2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P0CG47-1",
                "protein_name": "Polyubiquitin-B",
                "gene_name": "UBB",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P42224-1",
                "protein_name": "Signal transducer and activator of transcription 1-alpha/beta",
                "gene_name": "STAT1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q7Z3B4-1",
                "protein_name": "Nucleoporin p54",
                "gene_name": "NUP54",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P27361-1",
                "protein_name": "Mitogen-activated protein kinase 3",
                "gene_name": "MAPK3",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P80217-1",
                "protein_name": "Interferon-induced 35 kDa protein",
                "gene_name": "IFI35",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P62987-1",
                "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein",
                "gene_name": "UBA52",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q01628-1",
                "protein_name": "Interferon-induced transmembrane protein 3",
                "gene_name": "IFITM3",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9Y3Z3-1",
                "protein_name": "Deoxynucleoside triphosphate triphosphohydrolase SAMHD1",
                "gene_name": "SAMHD1",
                "tax_name": "Human"
            },
            {
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                "protein_name": "Guanylate-binding protein 2",
                "gene_name": "GBP2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q00978-1",
                "protein_name": "Interferon regulatory factor 9",
                "gene_name": "IRF9",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P01893-1",
                "protein_name": "Putative HLA class I histocompatibility antigen, alpha chain H",
                "gene_name": "HLA-H",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P12270-1",
                "protein_name": "Nucleoprotein TPR",
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                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P05161-1",
                "protein_name": "Ubiquitin-like protein ISG15",
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                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q14974-1",
                "protein_name": "Importin subunit beta-1",
                "gene_name": "KPNB1",
                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "P23458-1",
                "protein_name": "Tyrosine-protein kinase JAK1",
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                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "P17181-1",
                "protein_name": "Interferon alpha/beta receptor 1",
                "gene_name": "IFNAR1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P19174-1",
                "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1",
                "gene_name": "PLCG1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q13526-1",
                "protein_name": "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1",
                "gene_name": "PIN1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9NRG9-1",
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                "gene_name": "AAAS",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P0CG48-1",
                "protein_name": "Polyubiquitin-C",
                "gene_name": "UBC",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P01889-1",
                "protein_name": "HLA class I histocompatibility antigen, B alpha chain",
                "gene_name": "HLA-B",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P37198-1",
                "protein_name": "Nuclear pore glycoprotein p62",
                "gene_name": "NUP62",
                "tax_name": "Human"
            }
        ],
        "species": [
            {
                "name": "Homo sapiens",
                "taxid": 9606,
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "O15131",
                        "url": "https://www.uniprot.org/uniprotkb/O15131"
                    }
                ],
                "common_name": "Human",
                "glygen_name": "Human",
                "reference_species": "Homo sapiens [9606]"
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    {
        "title": "ISG15 modification of Ubc13 suppresses its ubiquitin-conjugating activity.",
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    {
        "title": "ISG15 modification of ubiquitin E2 Ubc13 disrupts its ability to form thioester bond with ubiquitin.",
        "journal": "Biochemical and biophysical research communications",
        "date": "2005",
        "authors": "Zou W, Papov V, Malakhova O, Kim KI, Dao C, Li J, Zhang DE",
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            {
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        "title": "The interferon-inducible ubiquitin-protein isopeptide ligase (E3) EFP also functions as an ISG15 E3 ligase.",
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        "date": "2006",
        "authors": "Zou W, Zhang DE",
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    {
        "title": "Herc5, an interferon-induced HECT E3 enzyme, is required for conjugation of ISG15 in human cells.",
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    {
        "title": "Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme.",
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        "authors": "Takeuchi T, Iwahara S, Saeki Y, Sasajima H, Yokosawa H",
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    {
        "title": "Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1.",
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    {
        "title": "Cumulative mutations of ubiquitin acceptor sites in human immunodeficiency virus type 1 gag cause a late budding defect.",
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    {
        "title": "HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets.",
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        "date": "2006",
        "authors": "Wong JJ, Pung YF, Sze NS, Chin KC",
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        "title": "Negative regulation of protein phosphatase 2Cbeta by ISG15 conjugation.",
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    {
        "title": "ISG15 enhances the innate antiviral response by inhibition of IRF-3 degradation.",
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        "title": "Inhibition of IRF3-dependent antiviral responses by cellular and viral proteins.",
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        "date": "2009",
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    {
        "title": "Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification.",
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