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        "record_id": "pubmed.11668633",
        "abstract": "",
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    {
        "title": "Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome.",
        "journal": "The Biochemical journal",
        "date": "2002",
        "authors": "Sapkota GP, Boudeau J, Deak M, Kieloch A, Morrice N, Alessi DR",
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            "type": "PubMed",
            "id": "11853558",
            "url": "https://pubmed.ncbi.nlm.nih.gov/11853558"
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        "referenced_glycans": [],
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            {
                "uniprot_canonical_ac": "Q15831-1",
                "protein_name": "Serine/threonine-protein kinase STK11",
                "gene_name": "STK11",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9WTK7-1",
                "protein_name": "Serine/threonine-protein kinase STK11",
                "gene_name": "Stk11",
                "tax_name": "Mouse"
            }
        ],
        "species": [
            {
                "name": "Homo sapiens",
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                    {
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                        "id": "Q15831",
                        "url": "https://www.uniprot.org/uniprotkb/Q15831"
                    }
                ],
                "common_name": "Human",
                "glygen_name": "Human",
                "reference_species": "Homo sapiens [9606]"
            }
        ],
        "phosphorylation": [
            {
                "start_pos": 189,
                "end_pos": 189,
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                "kinase_gene_name": "",
                "residue": "Thr",
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                    {
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                        "id": "Q15831",
                        "url": "https://www.uniprot.org/uniprotkb/Q15831"
                    },
                    {
                        "database": "iPTMnet",
                        "id": "Q15831",
                        "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q15831"
                    },
                    {
                        "database": "PubMed",
                        "id": "11853558",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11853558"
                    },
                    {
                        "database": "PubMed",
                        "id": "25005758",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/25005758"
                    }
                ],
                "site_lbl": "Thr189",
                "uniprot_canonical_ac": "Q15831-1"
            },
            {
                "start_pos": 31,
                "end_pos": 31,
                "kinase_uniprot_canonical_ac": "",
                "kinase_gene_name": "",
                "residue": "Ser",
                "comment": "Phosphoserine",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q15831",
                        "url": "https://www.uniprot.org/uniprotkb/Q15831"
                    },
                    {
                        "database": "PubMed",
                        "id": "23186163",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/23186163"
                    },
                    {
                        "database": "iPTMnet",
                        "id": "Q15831",
                        "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q15831"
                    },
                    {
                        "database": "PubMed",
                        "id": "11853558",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11853558"
                    },
                    {
                        "database": "PubMed",
                        "id": "20058876",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/20058876"
                    }
                ],
                "site_lbl": "Ser31",
                "uniprot_canonical_ac": "Q15831-1"
            },
            {
                "start_pos": 325,
                "end_pos": 325,
                "kinase_uniprot_canonical_ac": "",
                "kinase_gene_name": "",
                "residue": "Ser",
                "comment": "Phosphoserine",
                "evidence": [
                    {
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                        "id": "Q15831",
                        "url": "https://www.uniprot.org/uniprotkb/Q15831"
                    },
                    {
                        "database": "iPTMnet",
                        "id": "Q15831",
                        "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q15831"
                    },
                    {
                        "database": "PubMed",
                        "id": "11853558",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11853558"
                    }
                ],
                "site_lbl": "Ser325",
                "uniprot_canonical_ac": "Q15831-1"
            },
            {
                "start_pos": 336,
                "end_pos": 336,
                "kinase_uniprot_canonical_ac": "",
                "kinase_gene_name": "",
                "residue": "Thr",
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                    {
                        "database": "iPTMnet",
                        "id": "Q15831",
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                    },
                    {
                        "database": "PubMed",
                        "id": "11853558",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11853558"
                    },
                    {
                        "database": "PubMed",
                        "id": "12552571",
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                    {
                        "database": "PubMed",
                        "id": "22575644",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/22575644"
                    },
                    {
                        "database": "PubMed",
                        "id": "28708087",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/28708087"
                    }
                ],
                "site_lbl": "Thr336",
                "uniprot_canonical_ac": "Q15831-1"
            },
            {
                "start_pos": 363,
                "end_pos": 363,
                "kinase_uniprot_canonical_ac": "Q13315-1",
                "kinase_gene_name": "ATM",
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                        "database": "PubMed",
                        "id": "11853558",
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                    {
                        "database": "PubMed",
                        "id": "12234250",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12234250"
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                ],
                "site_lbl": "Thr363",
                "uniprot_canonical_ac": "Q15831-1"
            },
            {
                "start_pos": 428,
                "end_pos": 428,
                "kinase_uniprot_canonical_ac": "P17612-1",
                "kinase_gene_name": "PRKACA",
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                "comment": "",
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                    {
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                    {
                        "database": "PubMed",
                        "id": "11297520",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11297520"
                    },
                    {
                        "database": "PubMed",
                        "id": "11853558",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11853558"
                    }
                ],
                "site_lbl": "Ser428",
                "uniprot_canonical_ac": "Q15831-1"
            },
            {
                "start_pos": 428,
                "end_pos": 428,
                "kinase_uniprot_canonical_ac": "P23443-1",
                "kinase_gene_name": "RPS6KB1",
                "residue": "Ser",
                "comment": "",
                "evidence": [
                    {
                        "database": "iPTMnet",
                        "id": "Q15831",
                        "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q15831"
                    },
                    {
                        "database": "PubMed",
                        "id": "11297520",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11297520"
                    },
                    {
                        "database": "PubMed",
                        "id": "11853558",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11853558"
                    }
                ],
                "site_lbl": "Ser428",
                "uniprot_canonical_ac": "Q15831-1"
            },
            {
                "start_pos": 428,
                "end_pos": 428,
                "kinase_uniprot_canonical_ac": "P51812-1",
                "kinase_gene_name": "RPS6KA3",
                "residue": "Ser",
                "comment": "",
                "evidence": [
                    {
                        "database": "iPTMnet",
                        "id": "Q15831",
                        "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q15831"
                    },
                    {
                        "database": "PubMed",
                        "id": "11297520",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11297520"
                    },
                    {
                        "database": "PubMed",
                        "id": "11853558",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11853558"
                    }
                ],
                "site_lbl": "Ser428",
                "uniprot_canonical_ac": "Q15831-1"
            },
            {
                "start_pos": 31,
                "end_pos": 31,
                "kinase_uniprot_canonical_ac": "",
                "kinase_gene_name": "",
                "residue": "Ser",
                "comment": "Phosphoserine",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q9WTK7",
                        "url": "https://www.uniprot.org/uniprotkb/Q9WTK7"
                    },
                    {
                        "database": "PubMed",
                        "id": "21183079",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/21183079"
                    },
                    {
                        "database": "PubMed",
                        "id": "11853558",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11853558"
                    },
                    {
                        "database": "iPTMnet",
                        "id": "Q9WTK7",
                        "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9WTK7"
                    },
                    {
                        "database": "PubMed",
                        "id": "32841502",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/32841502"
                    }
                ],
                "site_lbl": "Ser31",
                "uniprot_canonical_ac": "Q9WTK7-1"
            },
            {
                "start_pos": 325,
                "end_pos": 325,
                "kinase_uniprot_canonical_ac": "",
                "kinase_gene_name": "",
                "residue": "Ser",
                "comment": "Phosphoserine",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q9WTK7",
                        "url": "https://www.uniprot.org/uniprotkb/Q9WTK7"
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                    {
                        "database": "PubMed",
                        "id": "11853558",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11853558"
                    },
                    {
                        "database": "iPTMnet",
                        "id": "Q9WTK7",
                        "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9WTK7"
                    }
                ],
                "site_lbl": "Ser325",
                "uniprot_canonical_ac": "Q9WTK7-1"
            },
            {
                "start_pos": 336,
                "end_pos": 336,
                "kinase_uniprot_canonical_ac": "Q9WTK7-1",
                "kinase_gene_name": "Stk11",
                "residue": "Thr",
                "comment": "",
                "evidence": [
                    {
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                        "id": "Q9WTK7",
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                    {
                        "database": "iPTMnet",
                        "id": "Q9WTK7",
                        "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9WTK7"
                    },
                    {
                        "database": "PubMed",
                        "id": "11853558",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11853558"
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                ],
                "site_lbl": "Thr336",
                "uniprot_canonical_ac": "Q9WTK7-1"
            },
            {
                "start_pos": 366,
                "end_pos": 366,
                "kinase_uniprot_canonical_ac": "Q9WTK7-1",
                "kinase_gene_name": "Stk11",
                "residue": "Thr",
                "comment": "",
                "evidence": [
                    {
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                        "id": "Q9WTK7",
                        "url": "https://www.uniprot.org/uniprotkb/Q9WTK7"
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                    {
                        "database": "iPTMnet",
                        "id": "Q9WTK7",
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                    {
                        "database": "PubMed",
                        "id": "11853558",
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                ],
                "site_lbl": "Thr366",
                "uniprot_canonical_ac": "Q9WTK7-1"
            },
            {
                "start_pos": 366,
                "end_pos": 366,
                "kinase_uniprot_canonical_ac": "",
                "kinase_gene_name": "",
                "residue": "Thr",
                "comment": "Phosphothreonine; by ATM and autocatalysis",
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                    {
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                        "id": "Q9WTK7",
                        "url": "https://www.uniprot.org/uniprotkb/Q9WTK7"
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                    {
                        "database": "iPTMnet",
                        "id": "Q9WTK7",
                        "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9WTK7"
                    },
                    {
                        "database": "PubMed",
                        "id": "12234250",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12234250"
                    },
                    {
                        "database": "PubMed",
                        "id": "20864035",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/20864035"
                    },
                    {
                        "database": "PubMed",
                        "id": "25329316",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/25329316"
                    },
                    {
                        "database": "PubMed",
                        "id": "11853558",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11853558"
                    }
                ],
                "site_lbl": "Thr366",
                "uniprot_canonical_ac": "Q9WTK7-1"
            }
        ],
        "mutagenesis": [
            {
                "start_pos": 194,
                "end_pos": 194,
                "sequence_org": "D",
                "sequence_mut": "A",
                "comment": "Loss of kinase activity and descreased phosphorylation.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q9WTK7",
                        "url": "https://www.uniprot.org/uniprotkb/Q9WTK7"
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                    {
                        "database": "PubMed",
                        "id": "11853558",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11853558"
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                ],
                "uniprot_canonical_ac": "Q9WTK7-1"
            },
            {
                "start_pos": 31,
                "end_pos": 31,
                "sequence_org": "S",
                "sequence_mut": "A",
                "comment": "No change in kinase activity; when associated with A-325; A-336 and A-366.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q9WTK7",
                        "url": "https://www.uniprot.org/uniprotkb/Q9WTK7"
                    },
                    {
                        "database": "PubMed",
                        "id": "11853558",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11853558"
                    }
                ],
                "uniprot_canonical_ac": "Q9WTK7-1"
            },
            {
                "start_pos": 325,
                "end_pos": 325,
                "sequence_org": "S",
                "sequence_mut": "A",
                "comment": "No change in kinase activity; when associated with A-31; A-336 and A-366.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q9WTK7",
                        "url": "https://www.uniprot.org/uniprotkb/Q9WTK7"
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                    {
                        "database": "PubMed",
                        "id": "11853558",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11853558"
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                "uniprot_canonical_ac": "Q9WTK7-1"
            },
            {
                "start_pos": 336,
                "end_pos": 336,
                "sequence_org": "T",
                "sequence_mut": "A",
                "comment": "Abolishes ability to suppress cell growth. Decreased phosphorylation; when associated with A-366. No change in kinase activity; when associated with A-31; A-325 and A-366.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q9WTK7",
                        "url": "https://www.uniprot.org/uniprotkb/Q9WTK7"
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                "uniprot_canonical_ac": "Q9WTK7-1"
            },
            {
                "start_pos": 366,
                "end_pos": 366,
                "sequence_org": "T",
                "sequence_mut": "A",
                "comment": "Diminished interaction with CDKN1A and impaired ability to repair UV-induced DNA damage by affecting CDKN1AUV-induced degradation. Decreased phosphorylation; when associated with A-336. No change in kinase activity; when associated with A-31; A-325 and A-336.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q9WTK7",
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                    {
                        "database": "PubMed",
                        "id": "20864035",
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                        "database": "PubMed",
                        "id": "12234250",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12234250"
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                "uniprot_canonical_ac": "Q9WTK7-1"
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            {
                "start_pos": 433,
                "end_pos": 433,
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