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    },
    {
        "title": "The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation.",
        "journal": "Nature communications",
        "date": "2018",
        "authors": "Nechama M, Kwon J, Wei S, Kyi AT, Welner RS, Ben-Dov IZ, Arredouani MS, Asara JM, Chen CH, Tsai CY, Nelson KF, Kobayashi KS, Israel E, Zhou XZ, Nicholson LK, Lu KP",
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            "type": "PubMed",
            "id": "29686383",
            "url": "https://pubmed.ncbi.nlm.nih.gov/29686383"
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            {
                "uniprot_canonical_ac": "Q8K4B2-1",
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                "tax_name": "Mouse"
            },
            {
                "uniprot_canonical_ac": "Q9Y616-1",
                "protein_name": "Interleukin-1 receptor-associated kinase 3",
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                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q13526-1",
                "protein_name": "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1",
                "gene_name": "PIN1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9QUR7-1",
                "protein_name": "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1",
                "gene_name": "Pin1",
                "tax_name": "Mouse"
            }
        ],
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            {
                "name": "Mus musculus",
                "taxid": 10090,
                "evidence": [
                    {
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                        "id": "Q8K4B2",
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                    }
                ],
                "common_name": "Mouse",
                "glygen_name": "Mouse",
                "reference_species": "Mus musculus [10090]"
            }
        ],
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            {
                "start_pos": 110,
                "end_pos": 110,
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                "sequence_mut": "A",
                "comment": "Abolishes phosphorylation. Abolishes interaction with PIN1. Reduces protein stability.",
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                    {
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                        "id": "Q9Y616",
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                        "id": "29686383",
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            },
            {
                "start_pos": 110,
                "end_pos": 110,
                "sequence_org": "S",
                "sequence_mut": "E",
                "comment": "Phosphomimic. Slight decrease in the interaction with PIN1. Weak interaction with PIN1 in absence of IL33-mediated dendritic cell stimulation. Increases resistant to degradation. Localizes to the nucleus in absence of stimulus. Does not affect isomerization of Pro-111 peptide bond.",
                "evidence": [
                    {
                        "database": "UniProtKB",
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                    {
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                        "id": "29686383",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/29686383"
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                ],
                "uniprot_canonical_ac": "Q9Y616-1"
            },
            {
                "start_pos": 467,
                "end_pos": 467,
                "sequence_org": "S",
                "sequence_mut": "A",
                "comment": "No effect on the interaction with PIN1.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q9Y616",
                        "url": "https://www.uniprot.org/uniprotkb/Q9Y616"
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                    {
                        "database": "PubMed",
                        "id": "29686383",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/29686383"
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                ],
                "uniprot_canonical_ac": "Q9Y616-1"
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            {
                "start_pos": 34,
                "end_pos": 34,
                "sequence_org": "W",
                "sequence_mut": "A",
                "comment": "Loss of binding to phosphorylated target proteins, including to phosphorylated RBBP8/CtIP; decrease in DNA repair of double-strand breaks by homologous recombination less efficient than that observed with wild-type protein. Abolishes interaction with IRAK3/IRAK-M. Abolishes IL33-mediated increase of IRAK3/IRAK-M protein levels.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q13526",
                        "url": "https://www.uniprot.org/uniprotkb/Q13526"
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                    {
                        "database": "PubMed",
                        "id": "22608923",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/22608923"
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                        "id": "23623683",
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                        "id": "29686383",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/29686383"
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                ],
                "uniprot_canonical_ac": "Q13526-1"
            },
            {
                "start_pos": 63,
                "end_pos": 63,
                "sequence_org": "K",
                "sequence_mut": "A",
                "comment": "Loss of peptidyl-prolyl cis/trans isomerase activity. No effect on the interaction with IRAK3/IRAK-M. Abolishes IL33-mediated increase of IRAK3/IRAK-M protein levels.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q13526",
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                    {
                        "database": "PubMed",
                        "id": "22608923",
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                "start_pos": 110,
                "end_pos": 110,
                "kinase_uniprot_canonical_ac": "",
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                "residue": "Ser",
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                "start_pos": 71,
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                        "id": "25849135",
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                        "id": "29665256",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/29665256"
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                    {
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                        "id": "35002518",
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                        "id": "29686383",
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                ],
                "site_lbl": "Ser71",
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            {
                "start_pos": 73,
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                "kinase_uniprot_canonical_ac": "",
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                        "id": "32448390",
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    {
        "title": "IRAK3-mediated suppression of pro-inflammatory MyD88/IRAK signaling affects disease severity in acute pancreatitis.",
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        "date": "2023-07-04",
        "authors": "Thiel Franziska G, Asgarbeik Saeedeh, Glaubitz Juliane, Wilden Anika, Lerch Markus M, Weiss Frank Ulrich, Sendler Matthias",
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    {
        "title": "Replenishing IRAK-M expression in retinal pigment epithelium attenuates outer retinal degeneration.",
        "journal": "Science translational medicine",
        "date": "2024-06-05",
        "authors": "Liu Jian, Copland David A, Clare Alison J, Gorski Mathias, Richards Burt T, Scott Louis, Theodoropoulou Sofia, Greferath Ursula, Cox Katherine, Shi Gongyu, Bell Oliver H, Ou Kepeng, Powell Jenna Le Brun, Wu Jiahui, Robles Luis Martinez, Li Yingxin, Nicholson Lindsay B, Coffey Peter J, Fletcher Erica L, Guymer Robyn, Radeke Monte J, Heid Iris M, Hageman Gregory S, Chan Ying Kai, Dick Andrew D",
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