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"gene_name": "H2AJ", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60814-1", "protein_name": "Histone H2B type 1-K", "gene_name": "H2BC12", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q93077-1", "protein_name": "Histone H2A type 1-C", "gene_name": "H2AC6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q93079-1", "protein_name": "Histone H2B type 1-H", "gene_name": "H2BC9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99879-1", "protein_name": "Histone H2B type 1-M", "gene_name": "H2BC14", "tax_name": "Human" }, { "uniprot_canonical_ac": "P11802-1", "protein_name": "Cyclin-dependent kinase 4", "gene_name": "CDK4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00534-1", "protein_name": "Cyclin-dependent kinase 6", "gene_name": "CDK6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42773-1", "protein_name": "Cyclin-dependent kinase 4 inhibitor C", "gene_name": "CDKN2C", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27361-1", "protein_name": "Mitogen-activated protein kinase 3", "gene_name": "MAPK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14186-1", "protein_name": "Transcription factor Dp-1", "gene_name": "TFDP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00716-1", "protein_name": "Transcription factor E2F3", "gene_name": "E2F3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14209-1", "protein_name": "Transcription factor E2F2", "gene_name": "E2F2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15054-2", "protein_name": "Lysine-specific demethylase 6B", "gene_name": "KDM6B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q71UI9-1", "protein_name": "Histone H2A.V", "gene_name": "H2AZ2", "tax_name": "Human" }, { 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No effect on PDGF-stimulated enhancement of transcriptional activity. Completely abolishes PDGF-stimulated enhancement of transcriptional activity; when associated with A-232; A-331 and A-374.", "evidence": [ { "database": "UniProtKB", "id": "P01101", "url": "https://www.uniprot.org/uniprotkb/P01101" }, { "database": "PubMed", "id": "12134156", "url": "https://pubmed.ncbi.nlm.nih.gov/12134156" }, { "database": "PubMed", "id": "12972619", "url": "https://pubmed.ncbi.nlm.nih.gov/12972619" } ], "uniprot_canonical_ac": "P01101-1" }, { "start_pos": 331, "end_pos": 331, "sequence_org": "T", "sequence_mut": "A", "comment": "Almost no EGF-mediated phosphorylation, greatly reduced cellular transformation, and reduced AP1 activity by 20%; when associated with A-325. No effect on PDGF-stimulated enhancement of transcriptional activity. 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Reduced AP1 activity by 65%.", "evidence": [ { "database": "UniProtKB", "id": "P01101", "url": "https://www.uniprot.org/uniprotkb/P01101" }, { "database": "PubMed", "id": "12134156", "url": "https://pubmed.ncbi.nlm.nih.gov/12134156" } ], "uniprot_canonical_ac": "P01101-1" }, { "start_pos": 345, "end_pos": 345, "sequence_org": "Y", "sequence_mut": "A", "comment": "Reduced phosphorylation by ERK.", "evidence": [ { "database": "UniProtKB", "id": "P01101", "url": "https://www.uniprot.org/uniprotkb/P01101" }, { "database": "PubMed", "id": "12134156", "url": "https://pubmed.ncbi.nlm.nih.gov/12134156" } ], "uniprot_canonical_ac": "P01101-1" }, { "start_pos": 362, "end_pos": 362, "sequence_org": "S", "sequence_mut": "D", "comment": "Enhanced EGF- and RSK-mediated transformation; when associated with D-374.", "evidence": [ { "database": "UniProtKB", "id": "P01101", "url": "https://www.uniprot.org/uniprotkb/P01101" }, { "database": "PubMed", "id": "12134156", "url": "https://pubmed.ncbi.nlm.nih.gov/12134156" } ], "uniprot_canonical_ac": "P01101-1" }, { "start_pos": 362, "end_pos": 362, "sequence_org": "S", "sequence_mut": "E", "comment": "Increased enhancement of EGF- and RSK-mediated transformation; when associated with E-374.", "evidence": [ { "database": "UniProtKB", "id": "P01101", "url": "https://www.uniprot.org/uniprotkb/P01101" }, { "database": "PubMed", "id": "12134156", "url": "https://pubmed.ncbi.nlm.nih.gov/12134156" } ], "uniprot_canonical_ac": "P01101-1" }, { "start_pos": 374, "end_pos": 374, "sequence_org": "S", "sequence_mut": "A", "comment": "No effect on PDGF-stimulated enhancement of transcriptional activity. 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"end_pos": 374, "sequence_org": "S", "sequence_mut": "E", "comment": "Enhanced EGF- and RSK-mediated transformation; when associated with E-362.", "evidence": [ { "database": "UniProtKB", "id": "P01101", "url": "https://www.uniprot.org/uniprotkb/P01101" }, { "database": "PubMed", "id": "12134156", "url": "https://pubmed.ncbi.nlm.nih.gov/12134156" }, { "database": "PubMed", "id": "12972619", "url": "https://pubmed.ncbi.nlm.nih.gov/12972619" } ], "uniprot_canonical_ac": "P01101-1" } ], "phosphorylation": [ { "start_pos": 325, "end_pos": 325, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine; by MAPK1 and MAPK3", "evidence": [ { "database": "UniProtKB", "id": "P01101", "url": "https://www.uniprot.org/uniprotkb/P01101" }, { "database": "PRO", "id": "P01101", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=P01101" }, { "database": "iPTMnet", "id": "P01101", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P01101" }, 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"kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine; by MAPK1 and MAPK3", "evidence": [ { "database": "UniProtKB", "id": "P01100", "url": "https://www.uniprot.org/uniprotkb/P01100" }, { "database": "PRO", "id": "P01100", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=P01100" }, { "database": "iPTMnet", "id": "P01100", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P01100" }, { "database": "PubMed", "id": "12134156", "url": "https://pubmed.ncbi.nlm.nih.gov/12134156" }, { "database": "PubMed", "id": "18822310", "url": "https://pubmed.ncbi.nlm.nih.gov/18822310" }, { "database": "PubMed", "id": "21552553", "url": "https://pubmed.ncbi.nlm.nih.gov/21552553" }, { "database": "PubMed", "id": "23667255", "url": "https://pubmed.ncbi.nlm.nih.gov/23667255" }, { "database": "PubMed", "id": "29422527", "url": "https://pubmed.ncbi.nlm.nih.gov/29422527" }, { "database": "PubMed", "id": "29535732", "url": "https://pubmed.ncbi.nlm.nih.gov/29535732" } ], 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