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"uniprot_canonical_ac": "P68400-1", "protein_name": "Casein kinase II subunit alpha", "gene_name": "CSNK2A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P67870-1", "protein_name": "Casein kinase II subunit beta", "gene_name": "CSNK2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24941-1", "protein_name": "Cyclin-dependent kinase 2", "gene_name": "CDK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96A56-1", "protein_name": "Tumor protein p53-inducible nuclear protein 1", "gene_name": "TP53INP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60921-1", "protein_name": "Checkpoint protein HUS1", "gene_name": "HUS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60671-1", "protein_name": "Cell cycle checkpoint protein RAD1", "gene_name": "RAD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99638-1", "protein_name": "Cell cycle checkpoint control protein RAD9A", "gene_name": "RAD9A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5B9-1", "protein_name": "FACT complex subunit SPT16", "gene_name": "SUPT16H", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15759-1", "protein_name": "Mitogen-activated protein kinase 11", "gene_name": "MAPK11", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15542-1", "protein_name": "Transcription initiation factor TFIID subunit 5", "gene_name": "TAF5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5H9L4-1", "protein_name": "Transcription initiation factor TFIID subunit 7-like", "gene_name": "TAF7L", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15545-1", "protein_name": "Transcription initiation factor TFIID subunit 7", "gene_name": "TAF7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13526-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1", "gene_name": "PIN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38398-1", "protein_name": "Breast cancer type 1 susceptibility protein", "gene_name": "BRCA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15151-1", "protein_name": "Protein Mdm4", "gene_name": "MDM4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P54619-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-1", "gene_name": "PRKAG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43741-1", "protein_name": "5'-AMP-activated protein kinase subunit beta-2", "gene_name": "PRKAB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13131-1", "protein_name": "5'-AMP-activated protein kinase catalytic subunit alpha-1", "gene_name": "PRKAA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P54646-1", "protein_name": "5'-AMP-activated protein kinase catalytic subunit alpha-2", "gene_name": "PRKAA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UGJ0-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-2", "gene_name": "PRKAG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00987-1", "protein_name": "E3 ubiquitin-protein ligase Mdm2", "gene_name": "MDM2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O96017-1", "protein_name": "Serine/threonine-protein kinase Chk2", "gene_name": "CHEK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y478-1", "protein_name": "5'-AMP-activated protein kinase subunit beta-1", "gene_name": "PRKAB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13315-1", "protein_name": "Serine-protein kinase ATM", "gene_name": "ATM", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9WV70-1", "protein_name": "Nucleolar complex protein 2 homolog", "gene_name": "Noc2l", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "P04637-1", "protein_name": "Cellular tumor antigen p53", "gene_name": "TP53", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q7Z7C8", "url": "https://www.uniprot.org/uniprotkb/Q7Z7C8" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.16322561", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 94 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation.", "journal": "Cancer research", "date": "2006", "authors": "Zeng PY, Berger SL", "reference": { "type": "PubMed", "id": "17108107", "url": "https://pubmed.ncbi.nlm.nih.gov/17108107" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q7Z7C8-1", "protein_name": "Transcription initiation factor TFIID subunit 8", "gene_name": "TAF8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15544-1", "protein_name": "Transcription initiation factor TFIID subunit 11", "gene_name": "TAF11", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92547-1", "protein_name": "DNA topoisomerase 2-binding protein 1", "gene_name": "TOPBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14965-1", "protein_name": "Aurora kinase A", "gene_name": "AURKA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16539-1", "protein_name": "Mitogen-activated protein kinase 14", "gene_name": "MAPK14", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20248-1", "protein_name": "Cyclin-A2", "gene_name": "CCNA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92993-1", "protein_name": "Histone acetyltransferase KAT5", "gene_name": "KAT5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96E14-1", "protein_name": "RecQ-mediated genome instability protein 2", "gene_name": "RMI2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75943-1", "protein_name": "Cell cycle checkpoint protein RAD17", "gene_name": "RAD17", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BSD3-1", "protein_name": "RAD9, HUS1, RAD1-interacting nuclear orphan protein 1", "gene_name": "RHNO1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VWG9-1", "protein_name": "Transcription initiation factor TFIID subunit 3", "gene_name": "TAF3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IW41-1", "protein_name": "MAP kinase-activated protein kinase 5", "gene_name": "MAPKAPK5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q08945-1", "protein_name": "FACT complex subunit SSRP1", "gene_name": "SSRP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19784-1", "protein_name": "Casein kinase II subunit alpha'", "gene_name": "CSNK2A2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16594-1", "protein_name": "Transcription initiation factor TFIID subunit 9", "gene_name": "TAF9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15543-1", "protein_name": "Transcription initiation factor TFIID subunit 13", "gene_name": "TAF13", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H4B4-1", "protein_name": "Serine/threonine-protein kinase PLK3", "gene_name": "PLK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35249-1", "protein_name": "Replication factor C subunit 4", "gene_name": "RFC4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35244-1", "protein_name": "Replication protein A 14 kDa subunit", "gene_name": "RPA3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13472-1", "protein_name": "DNA topoisomerase 3-alpha", "gene_name": "TOP3A", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60934-1", "protein_name": "Nibrin", "gene_name": "NBN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9ULW0-1", "protein_name": "Targeting protein for Xklp2", "gene_name": "TPX2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15078-1", "protein_name": "Cyclin-dependent kinase 5 activator 1", "gene_name": "CDK5R1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P51530-1", "protein_name": "DNA replication ATP-dependent helicase/nuclease DNA2", "gene_name": "DNA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WXE1-1", "protein_name": "ATR-interacting protein", "gene_name": "ATRIP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27694-1", "protein_name": "Replication protein A 70 kDa DNA-binding subunit", "gene_name": "RPA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P54132-1", "protein_name": "RecQ-like DNA helicase BLM", "gene_name": "BLM", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13535-1", "protein_name": "Serine/threonine-protein kinase ATR", "gene_name": "ATR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14191-1", "protein_name": "Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN", "gene_name": "WRN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P78396-1", "protein_name": "Cyclin-A1", "gene_name": "CCNA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H9A7-1", "protein_name": "RecQ-mediated genome instability protein 1", "gene_name": "RMI1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H2X6-1", "protein_name": "Homeodomain-interacting protein kinase 2", "gene_name": "HIPK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60285-1", "protein_name": "NUAK family SNF1-like kinase 1", "gene_name": "NUAK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35250-1", "protein_name": "Replication factor C subunit 2", "gene_name": "RFC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92750-1", "protein_name": "Transcription initiation factor TFIID subunit 4B", "gene_name": "TAF4B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49848-1", "protein_name": "Transcription initiation factor TFIID subunit 6", "gene_name": "TAF6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6P1X5-1", "protein_name": "Transcription initiation factor TFIID subunit 2", "gene_name": "TAF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00268-1", "protein_name": "Transcription initiation factor TFIID subunit 4", "gene_name": "TAF4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20226-1", "protein_name": "TATA-box-binding protein", "gene_name": "TBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92630-1", "protein_name": "Dual specificity tyrosine-phosphorylation-regulated kinase 2", "gene_name": "DYRK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15831-1", "protein_name": "Serine/threonine-protein kinase STK11", "gene_name": "STK11", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14757-1", "protein_name": "Serine/threonine-protein kinase Chk1", "gene_name": "CHEK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96GD4-1", "protein_name": "Aurora kinase B", "gene_name": "AURKB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UGI9-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-3", "gene_name": "PRKAG3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15927-1", "protein_name": "Replication protein A 32 kDa subunit", "gene_name": "RPA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P40938-1", "protein_name": "Replication factor C subunit 3", "gene_name": "RFC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49959-1", "protein_name": "Double-strand break repair protein MRE11", "gene_name": "MRE11", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UQ84-1", "protein_name": "Exonuclease 1", "gene_name": "EXO1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86Z02-1", "protein_name": "Homeodomain-interacting protein kinase 1", "gene_name": "HIPK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92804-1", "protein_name": "TATA-binding protein-associated factor 2N", "gene_name": "TAF15", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99728-1", "protein_name": "BRCA1-associated RING domain protein 1", "gene_name": "BARD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00535-1", "protein_name": "Cyclin-dependent kinase 5", "gene_name": "CDK5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99708-1", "protein_name": "DNA endonuclease RBBP8", "gene_name": "RBBP8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BX63-1", "protein_name": "Fanconi anemia group J protein", "gene_name": "BRIP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96S44-1", "protein_name": "EKC/KEOPS complex subunit TP53RK", "gene_name": "TP53RK", "tax_name": "Human" }, { "uniprot_canonical_ac": "P40937-1", "protein_name": "Replication factor C subunit 5", "gene_name": "RFC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6WBX8-5", "protein_name": "Cell cycle checkpoint control protein RAD9B", "gene_name": "RAD9B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16514-1", "protein_name": "Transcription initiation factor TFIID subunit 12", "gene_name": "TAF12", "tax_name": "Human" }, { "uniprot_canonical_ac": "P21675-2", "protein_name": "Transcription initiation factor TFIID subunit 1", "gene_name": "TAF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IZX4-1", "protein_name": "Transcription initiation factor TFIID subunit 1-like", "gene_name": "TAF1L", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HBM6-1", "protein_name": "Transcription initiation factor TFIID subunit 9B", "gene_name": "TAF9B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92878-1", "protein_name": "DNA repair protein RAD50", "gene_name": "RAD50", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q12962-1", "protein_name": "Transcription initiation factor TFIID subunit 10", "gene_name": "TAF10", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y3T9-1", "protein_name": "Nucleolar complex protein 2 homolog", "gene_name": "NOC2L", "tax_name": "Human" }, { "uniprot_canonical_ac": "P68400-1", "protein_name": "Casein kinase II subunit alpha", "gene_name": "CSNK2A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P67870-1", "protein_name": "Casein kinase II subunit beta", "gene_name": "CSNK2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24941-1", "protein_name": "Cyclin-dependent kinase 2", "gene_name": "CDK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": 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"uniprot_canonical_ac": "O75943-1", "protein_name": "Cell cycle checkpoint protein RAD17", "gene_name": "RAD17", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BSD3-1", "protein_name": "RAD9, HUS1, RAD1-interacting nuclear orphan protein 1", "gene_name": "RHNO1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VWG9-1", "protein_name": "Transcription initiation factor TFIID subunit 3", "gene_name": "TAF3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IW41-1", "protein_name": "MAP kinase-activated protein kinase 5", "gene_name": "MAPKAPK5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q08945-1", "protein_name": "FACT complex subunit SSRP1", "gene_name": "SSRP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19784-1", "protein_name": "Casein kinase II subunit alpha'", "gene_name": "CSNK2A2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16594-1", "protein_name": "Transcription initiation factor TFIID subunit 9", "gene_name": "TAF9", "tax_name": "Human" }, { 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"gene_name": "TAF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00268-1", "protein_name": "Transcription initiation factor TFIID subunit 4", "gene_name": "TAF4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20226-1", "protein_name": "TATA-box-binding protein", "gene_name": "TBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92630-1", "protein_name": "Dual specificity tyrosine-phosphorylation-regulated kinase 2", "gene_name": "DYRK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15831-1", "protein_name": "Serine/threonine-protein kinase STK11", "gene_name": "STK11", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14757-1", "protein_name": "Serine/threonine-protein kinase Chk1", "gene_name": "CHEK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96GD4-1", "protein_name": "Aurora kinase B", "gene_name": "AURKB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UGI9-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-3", "gene_name": "PRKAG3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15927-1", "protein_name": "Replication protein A 32 kDa subunit", "gene_name": "RPA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P40938-1", "protein_name": "Replication factor C subunit 3", "gene_name": "RFC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49959-1", "protein_name": "Double-strand break repair protein MRE11", "gene_name": "MRE11", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UQ84-1", "protein_name": "Exonuclease 1", "gene_name": "EXO1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86Z02-1", "protein_name": "Homeodomain-interacting protein kinase 1", "gene_name": "HIPK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92804-1", "protein_name": "TATA-binding protein-associated factor 2N", "gene_name": "TAF15", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99728-1", "protein_name": "BRCA1-associated RING domain protein 1", "gene_name": "BARD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00535-1", "protein_name": "Cyclin-dependent kinase 5", "gene_name": "CDK5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99708-1", "protein_name": "DNA endonuclease RBBP8", "gene_name": "RBBP8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BX63-1", "protein_name": "Fanconi anemia group J protein", "gene_name": "BRIP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96S44-1", "protein_name": "EKC/KEOPS complex subunit TP53RK", "gene_name": "TP53RK", "tax_name": "Human" }, { "uniprot_canonical_ac": "P40937-1", "protein_name": "Replication factor C subunit 5", "gene_name": "RFC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6WBX8-5", "protein_name": "Cell cycle checkpoint control protein RAD9B", "gene_name": "RAD9B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16514-1", "protein_name": "Transcription initiation factor TFIID subunit 12", "gene_name": "TAF12", "tax_name": "Human" }, { "uniprot_canonical_ac": "P21675-2", "protein_name": "Transcription initiation factor TFIID subunit 1", "gene_name": "TAF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IZX4-1", "protein_name": "Transcription initiation factor TFIID subunit 1-like", "gene_name": "TAF1L", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HBM6-1", "protein_name": "Transcription initiation factor TFIID subunit 9B", "gene_name": "TAF9B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92878-1", "protein_name": "DNA repair protein RAD50", "gene_name": "RAD50", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q12962-1", "protein_name": "Transcription initiation factor TFIID subunit 10", "gene_name": "TAF10", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y3T9-1", "protein_name": "Nucleolar complex protein 2 homolog", "gene_name": "NOC2L", "tax_name": "Human" }, { "uniprot_canonical_ac": "P68400-1", "protein_name": "Casein kinase II subunit alpha", "gene_name": "CSNK2A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P67870-1", "protein_name": "Casein kinase II subunit beta", "gene_name": "CSNK2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24941-1", "protein_name": "Cyclin-dependent kinase 2", "gene_name": "CDK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96A56-1", "protein_name": "Tumor protein p53-inducible nuclear protein 1", "gene_name": "TP53INP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60921-1", "protein_name": "Checkpoint protein HUS1", "gene_name": "HUS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60671-1", "protein_name": "Cell cycle checkpoint protein RAD1", "gene_name": "RAD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99638-1", "protein_name": "Cell cycle checkpoint control protein RAD9A", "gene_name": "RAD9A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5B9-1", "protein_name": "FACT complex subunit SPT16", "gene_name": "SUPT16H", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15759-1", "protein_name": "Mitogen-activated protein kinase 11", "gene_name": "MAPK11", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15542-1", "protein_name": "Transcription initiation factor TFIID subunit 5", "gene_name": "TAF5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5H9L4-1", "protein_name": "Transcription initiation factor TFIID subunit 7-like", "gene_name": "TAF7L", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15545-1", "protein_name": "Transcription initiation factor TFIID subunit 7", "gene_name": "TAF7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13526-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1", "gene_name": "PIN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38398-1", "protein_name": "Breast cancer type 1 susceptibility protein", "gene_name": "BRCA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15151-1", "protein_name": "Protein Mdm4", "gene_name": "MDM4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P54619-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-1", "gene_name": "PRKAG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43741-1", "protein_name": "5'-AMP-activated protein kinase subunit beta-2", "gene_name": "PRKAB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13131-1", "protein_name": "5'-AMP-activated protein kinase catalytic subunit alpha-1", "gene_name": "PRKAA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P54646-1", "protein_name": "5'-AMP-activated protein kinase catalytic subunit alpha-2", "gene_name": "PRKAA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UGJ0-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-2", "gene_name": "PRKAG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00987-1", "protein_name": "E3 ubiquitin-protein ligase Mdm2", "gene_name": "MDM2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O96017-1", "protein_name": "Serine/threonine-protein kinase Chk2", "gene_name": "CHEK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y478-1", "protein_name": "5'-AMP-activated protein kinase subunit beta-1", "gene_name": "PRKAB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13315-1", "protein_name": "Serine-protein kinase ATM", "gene_name": "ATM", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04637-1", "protein_name": "Cellular tumor antigen p53", "gene_name": "TP53", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q7Z7C8", "url": "https://www.uniprot.org/uniprotkb/Q7Z7C8" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.19121998", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 93 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage.", "journal": "The Journal of biological chemistry", "date": "2010", "authors": "Taira N, Yamamoto H, Yamaguchi T, Miki Y, Yoshida K", "reference": { "type": "PubMed", "id": "19965871", "url": "https://pubmed.ncbi.nlm.nih.gov/19965871" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q7Z7C8-1", "protein_name": "Transcription initiation factor TFIID subunit 8", "gene_name": "TAF8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15544-1", "protein_name": "Transcription initiation factor TFIID subunit 11", "gene_name": "TAF11", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92547-1", "protein_name": "DNA topoisomerase 2-binding protein 1", "gene_name": "TOPBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14965-1", "protein_name": "Aurora kinase A", "gene_name": "AURKA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16539-1", "protein_name": "Mitogen-activated protein kinase 14", "gene_name": "MAPK14", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20248-1", "protein_name": "Cyclin-A2", "gene_name": "CCNA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92993-1", "protein_name": "Histone acetyltransferase KAT5", "gene_name": "KAT5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96E14-1", "protein_name": "RecQ-mediated genome instability protein 2", "gene_name": "RMI2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75943-1", "protein_name": "Cell cycle checkpoint protein RAD17", "gene_name": "RAD17", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BSD3-1", "protein_name": "RAD9, HUS1, RAD1-interacting nuclear orphan protein 1", "gene_name": "RHNO1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VWG9-1", "protein_name": "Transcription initiation factor TFIID subunit 3", "gene_name": "TAF3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IW41-1", "protein_name": "MAP 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"n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Wu L, Ma CA, Zhao Y, Jain A", "reference": { "type": "PubMed", "id": "20959462", "url": "https://pubmed.ncbi.nlm.nih.gov/20959462" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q7Z7C8-1", "protein_name": "Transcription initiation factor TFIID subunit 8", "gene_name": "TAF8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15544-1", "protein_name": "Transcription initiation factor TFIID subunit 11", "gene_name": "TAF11", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92547-1", "protein_name": "DNA topoisomerase 2-binding protein 1", "gene_name": "TOPBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14965-1", "protein_name": "Aurora kinase A", "gene_name": "AURKA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16539-1", "protein_name": "Mitogen-activated protein kinase 14", "gene_name": "MAPK14", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20248-1", "protein_name": "Cyclin-A2", "gene_name": "CCNA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92993-1", "protein_name": "Histone acetyltransferase KAT5", "gene_name": "KAT5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96E14-1", "protein_name": "RecQ-mediated genome instability protein 2", "gene_name": "RMI2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75943-1", "protein_name": "Cell cycle checkpoint protein RAD17", "gene_name": "RAD17", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BSD3-1", "protein_name": "RAD9, HUS1, RAD1-interacting nuclear orphan protein 1", "gene_name": "RHNO1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VWG9-1", "protein_name": "Transcription initiation factor TFIID subunit 3", "gene_name": "TAF3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IW41-1", "protein_name": "MAP kinase-activated protein kinase 5", "gene_name": "MAPKAPK5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q08945-1", "protein_name": "FACT complex subunit SSRP1", "gene_name": "SSRP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19784-1", "protein_name": "Casein kinase II subunit alpha'", "gene_name": "CSNK2A2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16594-1", "protein_name": "Transcription initiation factor TFIID subunit 9", "gene_name": "TAF9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15543-1", "protein_name": "Transcription initiation factor TFIID subunit 13", "gene_name": "TAF13", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H4B4-1", "protein_name": "Serine/threonine-protein kinase PLK3", "gene_name": "PLK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35249-1", "protein_name": "Replication factor C subunit 4", "gene_name": "RFC4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35244-1", "protein_name": "Replication protein A 14 kDa subunit", "gene_name": "RPA3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13472-1", "protein_name": "DNA topoisomerase 3-alpha", "gene_name": "TOP3A", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60934-1", "protein_name": "Nibrin", "gene_name": "NBN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9ULW0-1", "protein_name": "Targeting protein for Xklp2", "gene_name": "TPX2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15078-1", "protein_name": "Cyclin-dependent kinase 5 activator 1", "gene_name": "CDK5R1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P51530-1", "protein_name": "DNA replication ATP-dependent helicase/nuclease DNA2", "gene_name": "DNA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WXE1-1", "protein_name": "ATR-interacting protein", "gene_name": "ATRIP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27694-1", "protein_name": "Replication protein A 70 kDa DNA-binding subunit", "gene_name": "RPA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P54132-1", "protein_name": "RecQ-like DNA helicase BLM", "gene_name": "BLM", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13535-1", "protein_name": "Serine/threonine-protein kinase ATR", "gene_name": "ATR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14191-1", "protein_name": "Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN", "gene_name": "WRN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P78396-1", "protein_name": "Cyclin-A1", "gene_name": "CCNA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H9A7-1", "protein_name": "RecQ-mediated genome instability protein 1", "gene_name": "RMI1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H2X6-1", "protein_name": "Homeodomain-interacting protein kinase 2", "gene_name": "HIPK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60285-1", "protein_name": "NUAK family SNF1-like kinase 1", "gene_name": "NUAK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35250-1", "protein_name": "Replication factor C subunit 2", "gene_name": "RFC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92750-1", "protein_name": "Transcription initiation factor TFIID subunit 4B", "gene_name": "TAF4B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49848-1", "protein_name": "Transcription initiation factor TFIID subunit 6", "gene_name": "TAF6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6P1X5-1", "protein_name": "Transcription initiation factor TFIID subunit 2", "gene_name": "TAF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00268-1", "protein_name": "Transcription initiation factor TFIID subunit 4", "gene_name": "TAF4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20226-1", "protein_name": "TATA-box-binding protein", "gene_name": "TBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92630-1", "protein_name": "Dual specificity tyrosine-phosphorylation-regulated kinase 2", "gene_name": "DYRK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15831-1", "protein_name": "Serine/threonine-protein kinase STK11", "gene_name": "STK11", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14757-1", "protein_name": "Serine/threonine-protein kinase Chk1", "gene_name": "CHEK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96GD4-1", "protein_name": "Aurora kinase B", "gene_name": "AURKB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UGI9-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-3", "gene_name": "PRKAG3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15927-1", "protein_name": "Replication protein A 32 kDa subunit", "gene_name": "RPA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P40938-1", "protein_name": "Replication factor C subunit 3", "gene_name": "RFC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49959-1", "protein_name": "Double-strand break repair protein MRE11", "gene_name": "MRE11", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UQ84-1", "protein_name": "Exonuclease 1", "gene_name": "EXO1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86Z02-1", "protein_name": "Homeodomain-interacting protein kinase 1", "gene_name": "HIPK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92804-1", "protein_name": "TATA-binding protein-associated factor 2N", "gene_name": "TAF15", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99728-1", "protein_name": "BRCA1-associated RING domain protein 1", "gene_name": "BARD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00535-1", "protein_name": "Cyclin-dependent kinase 5", "gene_name": "CDK5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99708-1", "protein_name": "DNA endonuclease RBBP8", "gene_name": "RBBP8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BX63-1", "protein_name": "Fanconi anemia group J protein", "gene_name": "BRIP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96S44-1", "protein_name": "EKC/KEOPS complex subunit TP53RK", "gene_name": "TP53RK", "tax_name": "Human" }, { "uniprot_canonical_ac": "P40937-1", "protein_name": "Replication factor C subunit 5", "gene_name": "RFC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6WBX8-5", "protein_name": "Cell cycle checkpoint control protein RAD9B", "gene_name": "RAD9B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16514-1", "protein_name": "Transcription initiation factor TFIID subunit 12", "gene_name": "TAF12", "tax_name": "Human" }, { "uniprot_canonical_ac": "P21675-2", "protein_name": "Transcription initiation factor TFIID subunit 1", "gene_name": "TAF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IZX4-1", "protein_name": "Transcription initiation factor TFIID subunit 1-like", "gene_name": "TAF1L", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HBM6-1", "protein_name": "Transcription initiation factor TFIID subunit 9B", "gene_name": "TAF9B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92878-1", "protein_name": "DNA repair protein RAD50", "gene_name": "RAD50", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q12962-1", "protein_name": "Transcription initiation factor TFIID subunit 10", "gene_name": "TAF10", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y3T9-1", "protein_name": "Nucleolar complex protein 2 homolog", "gene_name": "NOC2L", "tax_name": "Human" }, { "uniprot_canonical_ac": "P68400-1", "protein_name": "Casein kinase II subunit alpha", "gene_name": "CSNK2A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P67870-1", "protein_name": "Casein kinase II subunit beta", "gene_name": "CSNK2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24941-1", "protein_name": "Cyclin-dependent kinase 2", "gene_name": "CDK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96A56-1", "protein_name": "Tumor protein p53-inducible nuclear protein 1", "gene_name": "TP53INP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60921-1", "protein_name": "Checkpoint protein HUS1", "gene_name": "HUS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60671-1", "protein_name": "Cell cycle checkpoint protein RAD1", "gene_name": "RAD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99638-1", "protein_name": "Cell cycle checkpoint control protein RAD9A", "gene_name": "RAD9A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5B9-1", "protein_name": "FACT complex subunit SPT16", "gene_name": "SUPT16H", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15759-1", "protein_name": "Mitogen-activated protein kinase 11", "gene_name": "MAPK11", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15542-1", "protein_name": "Transcription initiation factor TFIID subunit 5", "gene_name": "TAF5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5H9L4-1", "protein_name": "Transcription initiation factor TFIID subunit 7-like", "gene_name": "TAF7L", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15545-1", "protein_name": "Transcription initiation factor TFIID subunit 7", "gene_name": "TAF7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13526-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1", "gene_name": "PIN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38398-1", "protein_name": "Breast cancer type 1 susceptibility protein", "gene_name": "BRCA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15151-1", "protein_name": "Protein Mdm4", "gene_name": "MDM4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P54619-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-1", "gene_name": "PRKAG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43741-1", "protein_name": "5'-AMP-activated protein kinase subunit beta-2", "gene_name": "PRKAB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13131-1", "protein_name": "5'-AMP-activated protein kinase catalytic subunit alpha-1", "gene_name": "PRKAA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P54646-1", "protein_name": "5'-AMP-activated protein kinase catalytic subunit alpha-2", "gene_name": "PRKAA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UGJ0-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-2", "gene_name": "PRKAG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00987-1", "protein_name": "E3 ubiquitin-protein ligase Mdm2", "gene_name": "MDM2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O96017-1", "protein_name": "Serine/threonine-protein kinase Chk2", "gene_name": "CHEK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y478-1", "protein_name": "5'-AMP-activated protein kinase subunit beta-1", "gene_name": "PRKAB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13315-1", "protein_name": "Serine-protein kinase ATM", "gene_name": "ATM", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04637-1", "protein_name": "Cellular tumor antigen p53", "gene_name": "TP53", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q7Z7C8", "url": "https://www.uniprot.org/uniprotkb/Q7Z7C8" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 183, "end_pos": 183, "sequence_org": "S", "sequence_mut": "A", "comment": "Abolishes strongly phosphorylation.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprotkb/P04637" }, { "database": "PubMed", "id": "20959462", "url": "https://pubmed.ncbi.nlm.nih.gov/20959462" } ], "uniprot_canonical_ac": "P04637-1" }, { "start_pos": 183, "end_pos": 183, "sequence_org": "S", "sequence_mut": "E", "comment": "Inhibits slightly its transcriptional activity.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": 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"sequence_mut": "E", "comment": "Inhibits strongly its transcriptional activity.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprotkb/P04637" }, { "database": "PubMed", "id": "20959462", "url": "https://pubmed.ncbi.nlm.nih.gov/20959462" } ], "uniprot_canonical_ac": "P04637-1" }, { "start_pos": 183, "end_pos": 183, "sequence_org": "S", "sequence_mut": "A", "comment": "Abolishes strongly phosphorylation.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprotkb/P04637" }, { "database": "PubMed", "id": "20959462", "url": "https://pubmed.ncbi.nlm.nih.gov/20959462" } ], "uniprot_canonical_ac": "P04637-1" }, { "start_pos": 183, "end_pos": 183, "sequence_org": "S", "sequence_mut": "E", "comment": "Inhibits slightly its transcriptional activity.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprotkb/P04637" }, { "database": "PubMed", "id": "20959462", "url": 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"sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "HIPK2 catalytic activity and subcellular localization are regulated by activation-loop Y354 autophosphorylation.", "journal": "Biochimica et biophysica acta", "date": "2013", "authors": "Siepi F, Gatti V, Camerini S, Crescenzi M, Soddu S", "reference": { "type": "PubMed", "id": "23485397", "url": "https://pubmed.ncbi.nlm.nih.gov/23485397" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q7Z7C8-1", "protein_name": "Transcription initiation factor TFIID subunit 8", "gene_name": "TAF8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15544-1", "protein_name": "Transcription initiation factor TFIID subunit 11", "gene_name": "TAF11", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92547-1", "protein_name": "DNA topoisomerase 2-binding protein 1", "gene_name": "TOPBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14965-1", "protein_name": "Aurora kinase A", "gene_name": "AURKA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16539-1", "protein_name": "Mitogen-activated protein kinase 14", "gene_name": "MAPK14", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20248-1", "protein_name": "Cyclin-A2", "gene_name": "CCNA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92993-1", "protein_name": "Histone acetyltransferase KAT5", "gene_name": "KAT5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96E14-1", "protein_name": "RecQ-mediated genome instability protein 2", "gene_name": "RMI2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75943-1", "protein_name": "Cell cycle checkpoint protein RAD17", "gene_name": "RAD17", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9QZR5-1", "protein_name": "Homeodomain-interacting protein kinase 2", "gene_name": "Hipk2", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BSD3-1", "protein_name": "RAD9, HUS1, RAD1-interacting nuclear orphan protein 1", "gene_name": "RHNO1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VWG9-1", "protein_name": "Transcription initiation factor TFIID subunit 3", "gene_name": 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tyrosine-phosphorylation-regulated kinase 2", "gene_name": "DYRK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15831-1", "protein_name": "Serine/threonine-protein kinase STK11", "gene_name": "STK11", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14757-1", "protein_name": "Serine/threonine-protein kinase Chk1", "gene_name": "CHEK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96GD4-1", "protein_name": "Aurora kinase B", "gene_name": "AURKB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UGI9-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-3", "gene_name": "PRKAG3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15927-1", "protein_name": "Replication protein A 32 kDa subunit", "gene_name": "RPA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P40938-1", "protein_name": "Replication factor C subunit 3", "gene_name": "RFC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49959-1", "protein_name": "Double-strand break repair protein 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"sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "AMPK couples p73 with p53 in cell fate decision.", "journal": "Cell death and differentiation", "date": "2014", "authors": "Adamovich Y, Adler J, Meltser V, Reuven N, Shaul Y", "reference": { "type": "PubMed", "id": "24874608", "url": "https://pubmed.ncbi.nlm.nih.gov/24874608" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q7Z7C8-1", "protein_name": "Transcription initiation factor TFIID subunit 8", "gene_name": "TAF8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15544-1", "protein_name": "Transcription initiation factor TFIID subunit 11", "gene_name": "TAF11", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92547-1", "protein_name": "DNA topoisomerase 2-binding protein 1", "gene_name": "TOPBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14965-1", "protein_name": "Aurora kinase A", "gene_name": "AURKA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16539-1", "protein_name": "Mitogen-activated protein kinase 14", "gene_name": "MAPK14", "tax_name": "Human" }, { 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"uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96A56-1", "protein_name": "Tumor protein p53-inducible nuclear protein 1", "gene_name": "TP53INP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60921-1", "protein_name": "Checkpoint protein HUS1", "gene_name": "HUS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60671-1", "protein_name": "Cell cycle checkpoint protein RAD1", "gene_name": "RAD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99638-1", "protein_name": "Cell cycle checkpoint control protein RAD9A", "gene_name": "RAD9A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5B9-1", "protein_name": "FACT complex subunit SPT16", "gene_name": "SUPT16H", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15759-1", "protein_name": "Mitogen-activated protein kinase 11", "gene_name": "MAPK11", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15542-1", "protein_name": "Transcription initiation factor TFIID subunit 5", "gene_name": "TAF5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5H9L4-1", "protein_name": "Transcription initiation factor TFIID subunit 7-like", "gene_name": "TAF7L", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15545-1", "protein_name": "Transcription initiation factor TFIID subunit 7", "gene_name": "TAF7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13526-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1", "gene_name": "PIN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38398-1", "protein_name": "Breast cancer type 1 susceptibility protein", "gene_name": "BRCA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15151-1", "protein_name": "Protein Mdm4", "gene_name": "MDM4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P54619-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-1", "gene_name": "PRKAG1", 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"count": 0 } ], "sort_fields": [] } ] }, { "title": "Homozygous TAF8 mutation in a patient with intellectual disability results in undetectable TAF8 protein, but preserved RNA polymerase II transcription.", "journal": "Hum. Mol. 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[] } ] }, { "title": "A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse beta-cells.", "journal": "Diabetes", "date": "2002", "authors": "Barg S, Eliasson L, Renstrom E, Rorsman P", "reference": { "type": "PubMed", "id": "11815462", "url": "https://pubmed.ncbi.nlm.nih.gov/11815462" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O00445-1", "protein_name": "Synaptotagmin-5", "gene_name": "SYT5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22694-1", "protein_name": "cAMP-dependent protein kinase catalytic subunit beta", "gene_name": "PRKACB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14643-1", "protein_name": "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1", "gene_name": "ITPR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63027-1", "protein_name": "Vesicle-associated membrane protein 2", "gene_name": "VAMP2", "tax_name": "Human" }, { 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"uniprot_canonical_ac": "P63096-1", "protein_name": "Guanine nucleotide-binding protein G(i) subunit alpha-1", "gene_name": "GNAI1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00555-8", "protein_name": "Voltage-dependent P/Q-type calcium channel subunit alpha-1A", "gene_name": "CACNA1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q09428-1", "protein_name": "ATP-binding cassette sub-family C member 8", "gene_name": "ABCC8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14654-1", "protein_name": "ATP-sensitive inward rectifier potassium channel 11", "gene_name": "KCNJ11", "tax_name": "Human" }, { "uniprot_canonical_ac": "P17612-1", "protein_name": "cAMP-dependent protein kinase catalytic subunit alpha", "gene_name": "PRKACA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04899-1", "protein_name": "Guanine nucleotide-binding protein G(i) subunit alpha-2", "gene_name": "GNAI2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43865-1", "protein_name": 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"glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.12196472", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 28 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Synaptosome-associated protein of 25 kilodaltons modulates Kv2.1 voltage-dependent K(+) channels in neuroendocrine islet beta-cells through an interaction with the channel N terminus.", "journal": "Molecular endocrinology (Baltimore, Md.)", "date": "2002", "authors": "MacDonald PE, Wang G, Tsuk S, Dodo C, Kang Y, Tang L, Wheeler MB, Cattral MS, Lakey JR, Salapatek AM, Lotan I, Gaisano HY", "reference": { "type": "PubMed", "id": "12403834", "url": "https://pubmed.ncbi.nlm.nih.gov/12403834" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O00445-1", "protein_name": "Synaptotagmin-5", "gene_name": "SYT5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22694-1", "protein_name": "cAMP-dependent protein kinase catalytic subunit beta", "gene_name": "PRKACB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14643-1", "protein_name": "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1", "gene_name": "ITPR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63027-1", "protein_name": "Vesicle-associated membrane protein 2", "gene_name": "VAMP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14721-1", "protein_name": "Potassium voltage-gated channel subfamily B member 1", "gene_name": "KCNB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14571-1", "protein_name": "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2", "gene_name": "ITPR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q01668-1", "protein_name": "Voltage-dependent L-type calcium channel subunit alpha-1D", "gene_name": "CACNA1D", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15878-1", "protein_name": "Voltage-dependent R-type calcium channel subunit alpha-1E", "gene_name": "CACNA1E", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NY47-1", "protein_name": "Voltage-dependent calcium channel subunit alpha-2/delta-2", "gene_name": "CACNA2D2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WZA2-1", "protein_name": "Rap guanine nucleotide exchange factor 4", "gene_name": "RAPGEF4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61764-1", "protein_name": 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[] } ] }, { "title": "GUIDE study: double-blind comparison of once-daily gliclazide MR and glimepiride in type 2 diabetic patients.", "journal": "European journal of clinical investigation", "date": "2004", "authors": "Schernthaner G, Grimaldi A, Di Mario U, Drzewoski J, Kempler P, Kvapil M, Novials A, Rottiers R, Rutten GE, Shaw KM", "reference": { "type": "PubMed", "id": "15305887", "url": "https://pubmed.ncbi.nlm.nih.gov/15305887" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O00445-1", "protein_name": "Synaptotagmin-5", "gene_name": "SYT5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22694-1", "protein_name": "cAMP-dependent protein kinase catalytic subunit beta", "gene_name": "PRKACB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14643-1", "protein_name": "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1", "gene_name": "ITPR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63027-1", "protein_name": "Vesicle-associated 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Endocrinology and metabolism", "date": "2005", "authors": "Yang SN, Berggren PO", "reference": { "type": "PubMed", "id": "15585596", "url": "https://pubmed.ncbi.nlm.nih.gov/15585596" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O00445-1", "protein_name": "Synaptotagmin-5", "gene_name": "SYT5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22694-1", "protein_name": "cAMP-dependent protein kinase catalytic subunit beta", "gene_name": "PRKACB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14643-1", "protein_name": "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1", "gene_name": "ITPR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63027-1", "protein_name": "Vesicle-associated membrane protein 2", "gene_name": "VAMP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14571-1", "protein_name": "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2", "gene_name": "ITPR2", "tax_name": "Human" }, { "uniprot_canonical_ac": 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"journal": "The Journal of biological chemistry", "date": "2006", "authors": "Lin YW, MacMullen C, Ganguly A, Stanley CA, Shyng SL", "reference": { "type": "PubMed", "id": "16332676", "url": "https://pubmed.ncbi.nlm.nih.gov/16332676" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O00445-1", "protein_name": "Synaptotagmin-5", "gene_name": "SYT5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22694-1", "protein_name": "cAMP-dependent protein kinase catalytic subunit beta", "gene_name": "PRKACB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14643-1", "protein_name": "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1", "gene_name": "ITPR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63027-1", "protein_name": "Vesicle-associated membrane protein 2", "gene_name": "VAMP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14571-1", "protein_name": "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2", "gene_name": "ITPR2", 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susceptibility gene variants KCNJ11 E23K and ABCC8 S1369A alter the ATP and sulfonylurea sensitivities of the ATP-sensitive K(+) channel.", "journal": "Diabetes", "date": "2009", "authors": "Hamming KS, Soliman D, Matemisz LC, Niazi O, Lang Y, Gloyn AL, Light PE", "reference": { "type": "PubMed", "id": "19587354", "url": "https://pubmed.ncbi.nlm.nih.gov/19587354" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O00445-1", "protein_name": "Synaptotagmin-5", "gene_name": "SYT5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22694-1", "protein_name": "cAMP-dependent protein kinase catalytic subunit beta", "gene_name": "PRKACB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14643-1", "protein_name": "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1", "gene_name": "ITPR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63027-1", "protein_name": "Vesicle-associated membrane protein 2", "gene_name": "VAMP2", "tax_name": "Human" }, { 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}, { "uniprot_canonical_ac": "O14610-1", "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2", "gene_name": "GNGT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01308-1", "protein_name": "Insulin", "gene_name": "INS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14573-1", "protein_name": "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3", "gene_name": "ITPR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43306-1", "protein_name": "Adenylate cyclase type 6", "gene_name": "ADCY6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18825-1", "protein_name": "Alpha-2C adrenergic receptor", "gene_name": "ADRA2C", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08913-1", "protein_name": "Alpha-2A adrenergic receptor", "gene_name": "ADRA2A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O00445", "url": "https://www.uniprot.org/uniprotkb/O00445" } ], 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phosphorylation determine glucose utilization.", "journal": "The Journal of clinical investigation", "date": "1994", "authors": "Morita H, Yano Y, Niswender KD, May JM, Whitesell RR, Wu L, Printz RL, Granner DK, Magnuson MA, Powers AC", "reference": { "type": "PubMed", "id": "7929812", "url": "https://pubmed.ncbi.nlm.nih.gov/7929812" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O00445-1", "protein_name": "Synaptotagmin-5", "gene_name": "SYT5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22694-1", "protein_name": "cAMP-dependent protein kinase catalytic subunit beta", "gene_name": "PRKACB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14643-1", "protein_name": "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1", "gene_name": "ITPR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63027-1", "protein_name": "Vesicle-associated membrane protein 2", "gene_name": "VAMP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14571-1", 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Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. 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"https://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ], "unlinked_id_list": [ "DOID:9460", "DOID:5166", "DOID:2021", "DOID:4114" ], "evidence": [ { "id": "363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:363" } ] }, { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate 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"" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": 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"MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] }, { "disease_id": "DOID:0070562", "recommended_name": { "id": "DOID:0070562", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0070562", "name": "Fanconi-Bickel syndrome", "description": "A glucose metabolism disease characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose that has_material_basis_in homozygous or compound heterozygous mutations in the SLC2A2 gene on chromosome 3q26.2." }, "synonyms": [ { "id": "DOID:0070562", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0070562", "name": "FBS", "description": "" }, { "id": "DOID:0070562", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0070562", "name": "glycogen storage disease XI", "description": "" }, { "id": "DOID:0070562", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0070562", "name": "glycogenosis type XI", "description": "" }, { "id": "DOID:0070562", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0070562", "name": "glycogenosis, Fanconi type", "description": "" }, { "id": "MONDO:0009216", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009216", "name": "glycogen storage disease due to GLUT2 deficiency", "description": "Fanconi-Bickel glycogenosis (FBG) is a rare glycogen storage disease characterized by hepatorenal glycogen accumulation, severe renal tubular dysfunction and impaired glucose and galactose metabolism." }, { "id": "MONDO:0009216", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009216", "name": "Bickel-Fanconi glycogenosis", "description": "" }, { "id": "MONDO:0009216", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009216", "name": "FBS", "description": "" }, { "id": "MONDO:0009216", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009216", "name": "Fanconi Bickel syndrome", "description": "" }, { "id": "MONDO:0009216", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009216", "name": "Fanconi syndrome with intestinal malabsorption and galactose intolerance", "description": "" }, { "id": "MONDO:0009216", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009216", "name": "Fanconi-Bickel disease", "description": "" }, { "id": "MONDO:0009216", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009216", "name": "Fanconi-Bickel syndrome", "description": "" }, { "id": "MONDO:0009216", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009216", "name": "GSD due to GLUT2 deficiency", "description": "" }, { "id": "MONDO:0009216", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009216", "name": "glycogen storage disease due to GLUT2 deficiency", "description": "" }, { "id": "MONDO:0009216", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009216", "name": "glycogenosis due to GLUT2 deficiency", "description": "" }, { "id": "MONDO:0009216", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009216", "name": "GLUT2 deficiency", "description": "" }, { "id": "MONDO:0009216", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009216", "name": "GSD type 11", "description": "" }, { "id": "MONDO:0009216", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009216", "name": "GSD type XI", "description": "" }, { "id": "MONDO:0009216", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009216", "name": "glycogen storage disease 11", "description": "" }, { "id": "MONDO:0009216", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009216", "name": "glycogen storage disease XI", "description": "" }, { "id": "MONDO:0009216", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009216", "name": "glycogen storage disease type 11", "description": "" }, { "id": "MONDO:0009216", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009216", "name": "glycogen storage disease type XI", "description": "" }, { "id": "MONDO:0009216", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009216", "name": "glycogenosis Fanconi EXACT", "description": "" }, { "id": "MONDO:0009216", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009216", "name": "hepatic glycogenosis with amino aciduria and glucosuria", "description": "" }, { "id": "MONDO:0009216", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009216", "name": "hepatorenal glycogenosis with renal Fanconi syndrome", "description": "" }, { "id": "MONDO:0009216", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009216", "name": "hepatorenal glycogenosis with renal fanconi syndrome", "description": "" }, { "id": "MONDO:0009216", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009216", "name": "pseudo-phlorizin diabetes", "description": "" }, { "id": "MIM:227810", "resource": "MIM", "url": "https://www.omim.org/entry/227810", "name": "Fanconi-Bickel syndrome", "description": "Fanconi-Bickel syndrome" } ], "unlinked_id_list": [], "evidence": [ { "id": "0070562", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0070562" }, { "id": "0070562", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0070562" } ] }, { "disease_id": "DOID:9352", "recommended_name": { "id": "DOID:9352", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9352", "name": "type 2 diabetes mellitus", "description": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin." }, "synonyms": [ { "id": "DOID:9352", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9352", "name": "NIDDM", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9352", "name": "non-insulin-dependent diabetes mellitus", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9352", "name": "type 2 diabetes", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9352", "name": "type II diabetes mellitus", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:9352", "name": "insulin resistance", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus", "description": "A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity." }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "NIDDM", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "T2D", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "T2DM", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "T2DM - type 2 diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "adult onset diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "adult-onset diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitis type 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitis type II", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, association with", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, late onset", 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"total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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