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Invest.", "date": "2020", "authors": "Kalailingam P, Wang KQ, Toh XR, Nguyen TQ, Chandrakanthan M, Hasan Z, Habib C, Schif A, Radio FC, Dallapiccola B, Weiss K, Nguyen LN", "reference": { "type": "PubMed", "id": "32369449", "url": "https://pubmed.ncbi.nlm.nih.gov/32369449" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q91X85-1", "protein_name": "Choline/ethanolamine transporter FLVCR2", "gene_name": "Flvcr2", "tax_name": "Mouse" } ], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q91X85", "url": "https://www.uniprot.org/uniprotkb/Q91X85" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "record_id": "pubmed.32369449", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Lack of Flvcr2 impairs brain angiogenesis without affecting the blood-brain barrier.", "journal": "J. Clin. Invest.", "date": "2020", "authors": "Santander N, Lizama CO, Meky E, McKinsey GL, Jung B, Sheppard D, Betsholtz C, Arnold TD", "reference": { "type": "PubMed", "id": "32369453", "url": "https://pubmed.ncbi.nlm.nih.gov/32369453" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q91X85-1", "protein_name": "Choline/ethanolamine transporter FLVCR2", "gene_name": "Flvcr2", "tax_name": "Mouse" } ], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q91X85", "url": "https://www.uniprot.org/uniprotkb/Q91X85" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "record_id": "pubmed.32369453", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", 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Federation of American Societies for Experimental Biology", "date": "2023-08", "authors": "Li Zhitong, Hao Jiaojiao, Li Longkai, Shen Nan, Wang Dapeng, Wang Nan, Wen Xinyu, Wang Weidong, Qin Biaojie, Tang Qingzhu, Guo Xianan, Song Huiyi, Du Xiangning, Yang Fan, Lin Hongli", "reference": { "type": "PubMed", "id": "37432656", "url": "https://pubmed.ncbi.nlm.nih.gov/37432656" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9WTS2-1", "protein_name": "Alpha-(1,6)-fucosyltransferase", "gene_name": "Fut8", "tax_name": "Mouse" } ], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q9WTS2", "url": "https://www.uniprot.org/uniprotkb/Q9WTS2" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "record_id": "pubmed.37432656", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Comparative characterization of GPRC5B and GPRC5CLacZ knockin mice; behavioral abnormalities in GPRC5B-deficient mice.", "journal": "Biochemical and biophysical research communications", "date": "2011", "authors": "Sano T, Kim YJ, Oshima E, Shimizu C, Kiyonari H, Abe T, Higashi H, Yamada K, Hirabayashi Y", "reference": { "type": "PubMed", "id": "21840300", "url": "https://pubmed.ncbi.nlm.nih.gov/21840300" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8K3J9-1", "protein_name": "G protein-coupled receptor family C group 5 member C", "gene_name": "Gprc5c", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q923Z0-1", "protein_name": "G protein-coupled receptor family C group 5 member B", "gene_name": "Gprc5b", "tax_name": "Mouse" } ], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { 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localization and exploring a functional role for Gprc5c in the kidney.", "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology", "date": "2018", "authors": "Rajkumar P, Cha B, Yin J, Arend LJ, Paunescu TG, Hirabayashi Y, Donowitz M, Pluznick JL", "reference": { "type": "PubMed", "id": "29196502", "url": "https://pubmed.ncbi.nlm.nih.gov/29196502" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8K3J9-1", "protein_name": "G protein-coupled receptor family C group 5 member C", "gene_name": "Gprc5c", "tax_name": "Mouse" } ], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q8K3J9", "url": "https://www.uniprot.org/uniprotkb/Q8K3J9" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "record_id": "pubmed.29196502", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], 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"count": 0 } ], "sort_fields": [] } ] }, { "title": "GPRC5C regulates the composition of cilia in the olfactory system.", "journal": "BMC biology", "date": "2023-12-18", "authors": "Bhat Sneha, Dietz Andr\u00e9, Senf Katja, Nietzsche Sandor, Hirabayashi Yoshio, Westermann Martin, Neuhaus Eva Maria", "reference": { "type": "PubMed", "id": "38110903", "url": "https://pubmed.ncbi.nlm.nih.gov/38110903" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8K3J9-1", "protein_name": "G protein-coupled receptor family C group 5 member C", "gene_name": "Gprc5c", "tax_name": "Mouse" } ], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q8K3J9", "url": "https://www.uniprot.org/uniprotkb/Q8K3J9" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "record_id": "pubmed.38110903", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], 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Chem.", "date": "2019", "authors": "Song C, Orlandi C, Sutton LP, Martemyanov KA", "reference": { "type": "PubMed", "id": "31311860", "url": "https://pubmed.ncbi.nlm.nih.gov/31311860" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P62881-1", "protein_name": "Guanine nucleotide-binding protein subunit beta-5", "gene_name": "Gnb5", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q8C419-1", "protein_name": "Metabotropic glycine receptor", "gene_name": "Gpr158", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "O54829-1", "protein_name": "Regulator of G protein signaling 7", "gene_name": "Rgs7", "tax_name": "Mouse" } ], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "P62881", "url": "https://www.uniprot.org/uniprotkb/P62881" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "record_id": "pubmed.31311860", "abstract": "", "glycosylation": [], 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Biol. Chem.", "date": "2001", "authors": "Goitsuka R, Tatsuno A, Ishiai M, Kurosaki T, Kitamura D", "reference": { "type": "PubMed", "id": "11463797", "url": "https://pubmed.ncbi.nlm.nih.gov/11463797" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q60631-1", "protein_name": "Growth factor receptor-bound protein 2", "gene_name": "Grb2", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q62077-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1", "gene_name": "Plcg1", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q9QZE2-1", "protein_name": "Cytokine-dependent hematopoietic cell linker", "gene_name": "Clnk", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "O54957-1", "protein_name": "Linker for activation of T-cells family member 1", "gene_name": "Lat", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "P27870-1", "protein_name": "Proto-oncogene vav", "gene_name": "Vav1", "tax_name": "Mouse" } ], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprotkb/Q60631" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "mutagenesis": [ { "start_pos": 101, "end_pos": 101, "sequence_org": "Y", "sequence_mut": "F", "comment": "Loss of phosphorylation and loss of interaction with PLCG1, PLCG2 and VAV. 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No effect on the suppression of natural killer cell activation and suppression of interferon-gamma production; when associated with F-69, F-101, F-153, F-174 and F-188.", "evidence": [ { "database": "UniProtKB", "id": "Q9QZE2", "url": "https://www.uniprot.org/uniprotkb/Q9QZE2" }, { "database": "PubMed", "id": "10744659", "url": "https://pubmed.ncbi.nlm.nih.gov/10744659" }, { "database": "PubMed", "id": "16439675", "url": "https://pubmed.ncbi.nlm.nih.gov/16439675" }, { "database": "PubMed", "id": "11463797", "url": "https://pubmed.ncbi.nlm.nih.gov/11463797" } ], "uniprot_canonical_ac": "Q9QZE2-1" } ], "phosphorylation": [ { "start_pos": 69, "end_pos": 69, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine; by LYN", "evidence": [ { "database": "UniProtKB", "id": "Q9QZE2", "url": "https://www.uniprot.org/uniprotkb/Q9QZE2" }, { "database": "iPTMnet", "id": "Q9QZE2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9QZE2" 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"n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Mouse alpha1-syntrophin binding to Grb2: further evidence of a role for syntrophin in cell signaling.", "journal": "Biochemistry", "date": "2001", "authors": "Oak S A, Russo K, Petrucci T C, Jarrett H W", "reference": { "type": "PubMed", "id": "11551227", "url": "https://pubmed.ncbi.nlm.nih.gov/11551227" }, "referenced_glycans": 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"table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells.", "journal": "Nat. Immunol.", "date": "2006", "authors": "Upshaw JL, Arneson LN, Schoon RA, Dick CJ, Billadeau DD, Leibson PJ", "reference": { "type": "PubMed", "id": "16582911", "url": "https://pubmed.ncbi.nlm.nih.gov/16582911" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q60631-1", "protein_name": "Growth factor receptor-bound protein 2", "gene_name": "Grb2", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UBK5-1", "protein_name": "Hematopoietic cell signal transducer", "gene_name": "HCST", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62993-1", "protein_name": "Growth factor receptor-bound protein 2", "gene_name": "GRB2", "tax_name": "Human" } ], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprotkb/Q60631" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "mutagenesis": [ { "start_pos": 88, "end_pos": 88, "sequence_org": "N", "sequence_mut": "Q", "comment": "Abrogates cell killing and interaction with GRB2. No effect on interaction with PIK3R1.", "evidence": [ { "database": "UniProtKB", "id": "Q9UBK5", "url": "https://www.uniprot.org/uniprotkb/Q9UBK5" }, { "database": "PubMed", "id": "16582911", "url": "https://pubmed.ncbi.nlm.nih.gov/16582911" } ], "uniprot_canonical_ac": "Q9UBK5-1" }, { "start_pos": 89, "end_pos": 89, "sequence_org": "M", "sequence_mut": "Q", "comment": "Abrogates cell killing and interaction with PIK3R1. No effect on interaction with GRB2.", "evidence": [ { "database": "UniProtKB", "id": "Q9UBK5", "url": "https://www.uniprot.org/uniprotkb/Q9UBK5" }, { "database": "PubMed", "id": "16582911", "url": "https://pubmed.ncbi.nlm.nih.gov/16582911" } ], "uniprot_canonical_ac": "Q9UBK5-1" } ], "phosphorylation": [ { "start_pos": 86, "end_pos": 86, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q9UBK5", "url": "https://www.uniprot.org/uniprotkb/Q9UBK5" }, { "database": "PubMed", "id": "16582911", "url": "https://pubmed.ncbi.nlm.nih.gov/16582911" }, { "database": "iPTMnet", "id": "Q9UBK5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9UBK5" } ], "site_lbl": "Tyr86", "uniprot_canonical_ac": "Q9UBK5-1" } ], "record_id": "pubmed.16582911", "abstract": "", "glycosylation": [], "snv": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl", "uniprot_canonical_ac" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "DNAM-1 controls NK cell activation via an ITT-like motif.", "journal": "J. Exp. Med.", "date": "2015", "authors": "Zhang Zhanguang, Wu Ning, Lu Yan, Davidson Dominique, Colonna Marco, Veillette Andr\u00e9", "reference": { "type": "PubMed", "id": "26552706", "url": "https://pubmed.ncbi.nlm.nih.gov/26552706" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q60631-1", "protein_name": "Growth factor receptor-bound protein 2", "gene_name": "Grb2", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q8K4F0-1", "protein_name": "CD226 antigen", "gene_name": "Cd226", "tax_name": "Mouse" } ], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprotkb/Q60631" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "mutagenesis": [ { "start_pos": 319, "end_pos": 319, "sequence_org": "Y", "sequence_mut": "F", "comment": "Abrogates the ability to bind GRB2 and its capacity to signal and enhance cytotoxicity.", "evidence": [ { "database": "UniProtKB", "id": "Q8K4F0", "url": "https://www.uniprot.org/uniprotkb/Q8K4F0" }, { "database": "PubMed", "id": "26552706", "url": "https://pubmed.ncbi.nlm.nih.gov/26552706" } ], "uniprot_canonical_ac": "Q8K4F0-1" } ], "phosphorylation": [ { "start_pos": 319, "end_pos": 319, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q8K4F0", "url": "https://www.uniprot.org/uniprotkb/Q8K4F0" }, { "database": "PubMed", "id": "26552706", "url": "https://pubmed.ncbi.nlm.nih.gov/26552706" } ], "site_lbl": "Tyr319", "uniprot_canonical_ac": "Q8K4F0-1" } ], "record_id": "pubmed.26552706", "abstract": "", "glycosylation": [], "snv": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl", "uniprot_canonical_ac" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Development of SH2 probes and pull-down assays to detect pathogen-induced, site-specific tyrosine phosphorylation of the TLR adaptor SCIMP.", "journal": "Immunol. Cell Biol.", "date": "2017", "authors": "Luo L, Tong SJ, Wall AA, Khromykh T, Sweet MJ, Stow JL", "reference": { "type": "PubMed", "id": "28290451", "url": "https://pubmed.ncbi.nlm.nih.gov/28290451" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q60631-1", "protein_name": "Growth factor receptor-bound protein 2", "gene_name": "Grb2", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "P41241-1", "protein_name": "Tyrosine-protein kinase CSK", "gene_name": "Csk", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q3UU41-1", "protein_name": "SLP adapter and CSK-interacting membrane protein", "gene_name": "Scimp", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q9QUN3-1", "protein_name": "B-cell linker protein", "gene_name": "Blnk", "tax_name": "Mouse" } ], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprotkb/Q60631" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "mutagenesis": [ { "start_pos": 120, "end_pos": 120, "sequence_org": "Y", "sequence_mut": "F", "comment": "Inhibits interaction with BLNK. No effect on interactions with TLR4, GRB2 and CSK.", "evidence": [ { "database": "UniProtKB", "id": "Q3UU41", "url": "https://www.uniprot.org/uniprotkb/Q3UU41" }, { "database": "PubMed", "id": "28290451", "url": "https://pubmed.ncbi.nlm.nih.gov/28290451" }, { "database": "PubMed", "id": "28098138", "url": "https://pubmed.ncbi.nlm.nih.gov/28098138" } ], "uniprot_canonical_ac": "Q3UU41-1" }, { "start_pos": 58, "end_pos": 58, "sequence_org": "Y", "sequence_mut": "F", "comment": "Inhibits interaction with BLNK. Slightly inhibits interaction with GRB2. No effect on interactions with TLR4 and CSK.", "evidence": [ { "database": "UniProtKB", "id": "Q3UU41", "url": "https://www.uniprot.org/uniprotkb/Q3UU41" }, { "database": "PubMed", "id": "28290451", "url": "https://pubmed.ncbi.nlm.nih.gov/28290451" }, { "database": "PubMed", "id": "28098138", "url": "https://pubmed.ncbi.nlm.nih.gov/28098138" } ], "uniprot_canonical_ac": "Q3UU41-1" }, { "start_pos": 96, "end_pos": 96, "sequence_org": "Y", "sequence_mut": "F", "comment": "Inhibits interaction with TLR4. Decreases IL12B expression after TLR4 activation by lipopolysaccharide. Inhibits interaction with CSK. 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Biol.", "date": "1997", "authors": "Wittekind M, Mapelli C, Lee V, Goldfarb V, Friedrichs M S, Meyers C A, Mueller L", "reference": { "type": "PubMed", "id": "9135122", "url": "https://pubmed.ncbi.nlm.nih.gov/9135122" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q60631-1", "protein_name": "Growth factor receptor-bound protein 2", "gene_name": "Grb2", "tax_name": "Mouse" } ], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprotkb/Q60631" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "record_id": "pubmed.9135122", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", 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alleviates hyperphosphorylation of Tau in Alzheimer's disease and vascular dementia.", "journal": "Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology", "date": "2023-06", "authors": "Zhang Heping, Lu Fan, Liu Panhong, Qiu Zhaohui, Li Jianling, Wang Xiaotong, Xu Hui, Zhao Yandong, Li Xuemin, Wang Huadong, Lu Daxiang, Qi Renbin", "reference": { "type": "PubMed", "id": "35080740", "url": "https://pubmed.ncbi.nlm.nih.gov/35080740" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q99PT1-1", "protein_name": "Rho GDP-dissociation inhibitor 1", "gene_name": "Arhgdia", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q5XI73-1", "protein_name": "Rho GDP-dissociation inhibitor 1", "gene_name": "Arhgdia", "tax_name": "Rat" } ], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q99PT1", "url": "https://www.uniprot.org/uniprotkb/Q99PT1" } ], "common_name": "Mouse", 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