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    {
        "title": "Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET.",
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    {
        "title": "TIF1beta regulates the pluripotency of embryonic stem cells in a phosphorylation-dependent manner.",
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        "date": "2010",
        "authors": "Seki Y, Kurisaki A, Watanabe-Susaki K, Nakajima Y, Nakanishi M, Arai Y, Shiota K, Sugino H, Asashima M",
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    {
        "title": "TRIM28 is required by the mouse KRAB domain protein ZFP568 to control convergent extension and morphogenesis of extra-embryonic tissues.",
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        "authors": "Shibata M, Blauvelt KE, Liem KF Jr, Garcia-Garcia MJ",
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                "comment": "In chato; probable null mutation. Almost abolishes transcriptional repression. No effect on interaction with THRIM28. Embryonic development arrests at stage 9 dpc. Widespread morphogenetic defects are found in all germ layers, associated with defective convergent extension movements. The anterior-posterior axis is abnormally shortened, somites are mediolaterally expanded, and the neural tube fails to close normally. Morphogenesis of most mesodermal tissues is also defective. The definitive endoderm fails to narrow and elongate leading to an open gut tube. Extraembryonic tissues are also abnormal with bubble-like protrusions in the yolk sac, aberrant migration of extraembryonic mesoderm, and incomplete placental development. Abolishes interaction with TRIM28; when associated with P-154.",
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        "title": "SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age.",
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    {
        "title": "The Transcriptional Repressive Activity of KRAB Zinc Finger Proteins Does Not Correlate with Their Ability to Recruit TRIM28.",
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        "date": "2016",
        "authors": "Murphy KE, Shylo NA, Alexander KA, Churchill AJ, Copperman C, Garcia-Garcia MJ",
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                "protein_name": "Transcription intermediary factor 1-beta",
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            {
                "uniprot_canonical_ac": "E9PYI1-1",
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        ],
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                "name": "Mus musculus",
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                "evidence": [
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                        "database": "UniProtKB",
                        "id": "Q62318",
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                ],
                "common_name": "Mouse",
                "glygen_name": "Mouse",
                "reference_species": "Mus musculus [10090]"
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        ],
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            {
                "start_pos": 128,
                "end_pos": 129,
                "sequence_org": "DV",
                "sequence_mut": "AA",
                "comment": "No effect on transcriptional repression. No effect on interaction with THRIM28.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "E9PYI1",
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            {
                "start_pos": 154,
                "end_pos": 154,
                "sequence_org": "L",
                "sequence_mut": "P",
                "comment": "No effect on transcriptional repression. Abolishes interaction with TRIM28; when associated with P-64.",
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                    {
                        "database": "UniProtKB",
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            {
                "start_pos": 37,
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            {
                "start_pos": 38,
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                "comment": "In chato; probable null mutation. Almost abolishes transcriptional repression. No effect on interaction with THRIM28. Embryonic development arrests at stage 9 dpc. Widespread morphogenetic defects are found in all germ layers, associated with defective convergent extension movements. The anterior-posterior axis is abnormally shortened, somites are mediolaterally expanded, and the neural tube fails to close normally. Morphogenesis of most mesodermal tissues is also defective. The definitive endoderm fails to narrow and elongate leading to an open gut tube. Extraembryonic tissues are also abnormal with bubble-like protrusions in the yolk sac, aberrant migration of extraembryonic mesoderm, and incomplete placental development. Abolishes interaction with TRIM28; when associated with P-154.",
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        "species": [
            {
                "name": "Mus musculus",
                "taxid": 10090,
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q9QUK6",
                        "url": "https://www.uniprot.org/uniprotkb/Q9QUK6"
                    }
                ],
                "common_name": "Mouse",
                "glygen_name": "Mouse",
                "reference_species": "Mus musculus [10090]"
            }
        ],
        "mutagenesis": [
            {
                "start_pos": 120,
                "end_pos": 120,
                "sequence_org": "Y",
                "sequence_mut": "F",
                "comment": "Inhibits interaction with BLNK. No effect on interactions with TLR4, GRB2 and CSK.",
                "evidence": [
                    {
                        "database": "UniProtKB",
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                        "url": "https://www.uniprot.org/uniprotkb/Q3UU41"
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                    {
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                    {
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                "uniprot_canonical_ac": "Q3UU41-1"
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                "start_pos": 58,
                "end_pos": 58,
                "sequence_org": "Y",
                "sequence_mut": "F",
                "comment": "Inhibits interaction with BLNK. Slightly inhibits interaction with GRB2. No effect on interactions with TLR4 and CSK.",
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                    {
                        "database": "UniProtKB",
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            },
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                "start_pos": 95,
                "end_pos": 95,
                "sequence_org": "W",
                "sequence_mut": "A",
                "comment": "Inhibits interaction with TLR4. Inhibits IL12B expression after TLR4 activation by lipopolysaccharide. No effect on interaction with LYN.",
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                    {
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                "end_pos": 96,
                "sequence_org": "Y",
                "sequence_mut": "F",
                "comment": "Inhibits interaction with TLR4. Decreases IL12B expression after TLR4 activation by lipopolysaccharide. Inhibits interaction with CSK. No effect on interactions with LYN, GRB2, and BLNK.",
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                    {
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            },
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                "start_pos": 97,
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                "sequence_org": "S",
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                "comment": "No effect on interaction with TLR4.",
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                "sequence_org": "S",
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                "comment": "No effect on interaction with TLR4.",
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            },
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                "start_pos": 99,
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                "sequence_org": "V",
                "sequence_mut": "A",
                "comment": "No effect on interaction with TLR4.",
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                        "id": "Q3UU41",
                        "url": "https://www.uniprot.org/uniprotkb/Q3UU41"
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                "end_pos": 96,
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                    {
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                "site_lbl": "Tyr96",
                "uniprot_canonical_ac": "Q3UU41-1"
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        "record_id": "pubmed.28098138",
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                "table_id": "glycosylation_reported_with_glycan",
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    {
        "title": "The lectin-specific activity of Toxoplasma gondii microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune priming.",
        "journal": "PLoS pathogens",
        "date": "2019-06",
        "authors": "Sardinha-Silva Aline, Mendon\u00e7a-Natividade Fl\u00e1via C, Pinzan Camila F, Lopes Carla D, Costa Diego L, Jacot Damien, Fernandes Fabricio F, Zorzetto-Fernandes Andr\u00e9 L V, Gay Nicholas J, Sher Alan, Jankovic Dragana, Soldati-Favre Dominique, Grigg Michael E, Roque-Barreira Maria Cristina",
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        ],
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    {
        "title": "Microneme Proteins 1 and 4 From Toxoplasma gondii Induce IL-10 Production by Macrophages Through TLR4 Endocytosis.",
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        "date": "2021",
        "authors": "Ricci-Azevedo Rafael, Mendon\u00e7a-Natividade Flavia Costa, Santana Ana Carolina, Alcoforado Diniz Juliana, Roque-Barreira Maria Cristina",
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