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ligand selectivity and agonist activation in the PPAR family.", "journal": "Structure", "date": "2001", "authors": "Cronet P, Petersen J F, Folmer R, Blomberg N, Sj\u00f6blom K, Karlsson U, Lindstedt E L, Bamberg K", "reference": { "type": "PubMed", "id": "11587644", "url": "https://pubmed.ncbi.nlm.nih.gov/11587644" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P37231-1", "protein_name": "Peroxisome proliferator-activated receptor gamma", "gene_name": "PPARG", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q07869-1", "protein_name": "Peroxisome proliferator-activated receptor alpha", "gene_name": "PPARA", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P37231", "url": "https://www.uniprot.org/uniprotkb/P37231" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11587644", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors.", "journal": "Proc. 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U.S.A.", "date": "2001", "authors": "Xu H E, Lambert M H, Montana V G, Plunket K D, Moore L B, Collins J L, Oplinger J A, Kliewer S A, Gampe R T, McKee D D, Moore J T, Willson T M", "reference": { "type": "PubMed", "id": "11698662", "url": "https://pubmed.ncbi.nlm.nih.gov/11698662" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P37231-1", "protein_name": "Peroxisome proliferator-activated receptor gamma", "gene_name": "PPARG", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q07869-1", "protein_name": "Peroxisome proliferator-activated receptor alpha", "gene_name": "PPARA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19793-1", "protein_name": "Retinoic acid receptor RXR-alpha", "gene_name": "RXRA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15788-1", "protein_name": "Nuclear receptor coactivator 1", "gene_name": "NCOA1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": 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Biophys. Res. Commun.", "date": "2004", "authors": "Bu H, Kashireddy P, Chang J, Zhu YT, Zhang Z, Zheng W, Rao SM, Zhu YJ", "reference": { "type": "PubMed", "id": "15047147", "url": "https://pubmed.ncbi.nlm.nih.gov/15047147" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P37231-1", "protein_name": "Peroxisome proliferator-activated receptor gamma", "gene_name": "PPARG", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92731-1", "protein_name": "Estrogen receptor beta", "gene_name": "ESR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19793-1", "protein_name": "Retinoic acid receptor RXR-alpha", "gene_name": "RXRA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P03372-1", "protein_name": "Estrogen receptor", "gene_name": "ESR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5QJE6-1", "protein_name": "Deoxynucleotidyltransferase terminal-interacting protein 2", "gene_name": "DNTTIP2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P37231", "url": "https://www.uniprot.org/uniprotkb/P37231" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.15047147", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 5 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Structure-based design of potent retinoid X receptor alpha agonists.", "journal": "J. Med. Chem.", "date": "2004", "authors": "Haffner Curt D, Lenhard James M, Miller Aaron B, McDougald Darryl L, Dwornik Kate, Ittoop Olivia R, Gampe Robert T, Xu H Eric, Blanchard Steve, Montana Valerie G, Consler Tom G, Bledsoe Randy K, Ayscue Andrea, Croom Dallas", "reference": { "type": "PubMed", "id": "15056000", "url": "https://pubmed.ncbi.nlm.nih.gov/15056000" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P37231-1", "protein_name": "Peroxisome proliferator-activated receptor gamma", "gene_name": "PPARG", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P37231", "url": "https://www.uniprot.org/uniprotkb/P37231" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.15056000", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "A new class of peroxisome proliferator-activated receptor agonists with a novel binding epitope shows antidiabetic effects.", "journal": "J. Biol. Chem.", "date": "2004", "authors": "Ostberg Tove, Svensson Stefan, Sel\u00e9n G\u00f6ran, Uppenberg Jonas, Thor Markus, Sundbom Maj, Sydow-B\u00e4ckman Mona, Gustavsson Anna-Lena, Jendeberg Lena", "reference": { "type": "PubMed", "id": "15258145", "url": "https://pubmed.ncbi.nlm.nih.gov/15258145" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P37231-1", "protein_name": "Peroxisome proliferator-activated receptor gamma", "gene_name": "PPARG", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P37231", "url": "https://www.uniprot.org/uniprotkb/P37231" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.15258145", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", 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Med. Chem.", "date": "2005", "authors": "Shi Guo Q, Dropinski James F, McKeever Brian M, Xu Shihua, Becker Joseph W, Berger Joel P, MacNaul Karen L, Elbrecht Alex, Zhou Gaochao, Doebber Thomas W, Wang Peiran, Chao Yu-Sheng, Forrest Mike, Heck James V, Moller David E, Jones A Brian", "reference": { "type": "PubMed", "id": "15974597", "url": "https://pubmed.ncbi.nlm.nih.gov/15974597" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P37231-1", "protein_name": "Peroxisome proliferator-activated receptor gamma", "gene_name": "PPARG", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P37231", "url": "https://www.uniprot.org/uniprotkb/P37231" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.15974597", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], 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Chem.", "date": "2006", "authors": "Mahindroo Neeraj, Wang Chiung-Chiu, Liao Chun-Chen, Huang Chien-Fu, Lu I-Lin, Lien Tzu-Wen, Peng Yi-Huei, Huang Wei-Jan, Lin Ying-Ting, Hsu Ming-Chen, Lin Chia-Hui, Tsai Chia-Hua, Hsu John T-A, Chen Xin, Lyu Ping-Chiang, Chao Yu-Sheng, Wu Su-Ying, Hsieh Hsing-Pang", "reference": { "type": "PubMed", "id": "16451087", "url": "https://pubmed.ncbi.nlm.nih.gov/16451087" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P37231-1", "protein_name": "Peroxisome proliferator-activated receptor gamma", "gene_name": "PPARG", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P37231", "url": "https://www.uniprot.org/uniprotkb/P37231" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.16451087", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], 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Biophys. Res. 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"count": 0 } ], "sort_fields": [] } ] }, { "title": "Bifidobacterium bifidum Strain BB1 Inhibits Tumor Necrosis Factor-\u03b1-Induced Increase in Intestinal Epithelial Tight Junction Permeability via Toll-Like Receptor-2/Toll-Like Receptor-6 Receptor Complex-Dependent Stimulation of Peroxisome Proliferator-Activated Receptor \u03b3 and Suppression of NF-\u03baB p65.", "journal": "The American journal of pathology", "date": "2024-09", "authors": "Abdulqadir Raz, Al-Sadi Rana, Haque Mohammad, Gupta Yash, Rawat Manmeet, Ma Thomas Y", "reference": { "type": "PubMed", "id": "38885924", "url": "https://pubmed.ncbi.nlm.nih.gov/38885924" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P37231-1", "protein_name": "Peroxisome proliferator-activated receptor gamma", "gene_name": "PPARG", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y2C9-1", "protein_name": "Toll-like receptor 6", "gene_name": "TLR6", "tax_name": "Human" } ], "species": [ { "name": "Homo 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"count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Cloning, expression, and alternative splicing of the novel isoform of hTCP11 gene.", "journal": "Zhongguo Yi Xue Ke Xue Yuan Xue Bao", "date": "2003", "authors": "Ma Yong-xin, Zhang Si-zhong, Wu Qia-qing, Sun Yan, Qiu Wei-min, Xu Wen-ming", "reference": { "type": "PubMed", "id": "12905703", "url": "https://pubmed.ncbi.nlm.nih.gov/12905703" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8WWU5-1", "protein_name": "T-complex protein 11 homolog", "gene_name": "TCP11", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8WWU5", "url": "https://www.uniprot.org/uniprotkb/Q8WWU5" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.12905703", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], 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Med.", "date": "2011", "authors": "Liu Yanyan, Jiang Min, Li Chao, Yang Ping, Sun Huaqin, Tao Dachang, Zhang Sizhong, Ma Yongxin", "reference": { "type": "PubMed", "id": "21597245", "url": "https://pubmed.ncbi.nlm.nih.gov/21597245" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8WWU5-1", "protein_name": "T-complex protein 11 homolog", "gene_name": "TCP11", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14990-1", "protein_name": "Outer dense fiber protein 1", "gene_name": "ODF1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8WWU5", "url": "https://www.uniprot.org/uniprotkb/Q8WWU5" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.21597245", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": 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Med. Chem.", "date": "2011", "authors": "Debdab Mansour, Carreaux Fran\u00e7ois, Renault Steven, Soundararajan Meera, Fedorov Oleg, Filippakopoulos Panagis, Lozach Olivier, Babault Lucie, Tahtouh Tania, Baratte Blandine, Ogawa Yasushi, Hagiwara Masatoshi, Eisenreich Andreas, Rauch Ursula, Knapp Stefan, Meijer Laurent, Bazureau Jean-Pierre", "reference": { "type": "PubMed", "id": "21615147", "url": "https://pubmed.ncbi.nlm.nih.gov/21615147" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P49761-1", "protein_name": "Dual specificity protein kinase CLK3", "gene_name": "CLK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22518-1", "protein_name": "Dual specificity protein kinase CLK1", "gene_name": "Clk1", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "O35492-1", "protein_name": "Dual specificity protein kinase CLK3", "gene_name": "Clk3", "tax_name": "Mouse" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": 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promoted colorectal cancer proliferation by activating IL-6/STAT3 signaling.", "journal": "Experimental cell research", "date": "2024-07-01", "authors": "Ma Yulin, Gao Fei, Liu Yang", "reference": { "type": "PubMed", "id": "38885806", "url": "https://pubmed.ncbi.nlm.nih.gov/38885806" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P49761-1", "protein_name": "Dual specificity protein kinase CLK3", "gene_name": "CLK3", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P49761", "url": "https://www.uniprot.org/uniprotkb/P49761" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.38885806", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], 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