[
    {
        "title": "Covalent modifications of the ebola virus glycoprotein.",
        "journal": "Journal of virology",
        "date": "2002-12",
        "authors": "Jeffers Scott A, Sanders David Avram, Sanchez Anthony",
        "reference": {
            "type": "PubMed",
            "id": "12438572",
            "url": "https://pubmed.ncbi.nlm.nih.gov/12438572"
        },
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                "uniprot_canonical_ac": "Q05320-1",
                "protein_name": "Envelope glycoprotein",
                "gene_name": "GP",
                "tax_name": "Zaire ebolavirus"
            }
        ],
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                "name": "Zaire ebolavirus (strain Mayinga-76)",
                "taxid": 128952,
                "evidence": [
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                        "id": "Q05320",
                        "url": "https://www.uniprot.org/uniprotkb/Q05320"
                    }
                ],
                "common_name": "Zaire ebolavirus",
                "glygen_name": "Ebola (EBOV)",
                "reference_species": "Zaire ebolavirus (strain Mayinga-76) [128952]"
            }
        ],
        "mutagenesis": [
            {
                "start_pos": 108,
                "end_pos": 108,
                "sequence_org": "C",
                "sequence_mut": "G",
                "comment": "Almost complete loss of expression of GP1 and GP2. Almost complete loss of virus capability to enter into host cell.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q05320",
                        "url": "https://www.uniprot.org/uniprotkb/Q05320"
                    },
                    {
                        "database": "PubMed",
                        "id": "12438572",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12438572"
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                ],
                "uniprot_canonical_ac": "Q05320-1"
            },
            {
                "start_pos": 121,
                "end_pos": 121,
                "sequence_org": "C",
                "sequence_mut": "G",
                "comment": "Reduced levels of expression of GP1 and GP2. 50% loss of virus capability to enter into host cell.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q05320",
                        "url": "https://www.uniprot.org/uniprotkb/Q05320"
                    },
                    {
                        "database": "PubMed",
                        "id": "12438572",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12438572"
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                ],
                "uniprot_canonical_ac": "Q05320-1"
            },
            {
                "start_pos": 135,
                "end_pos": 135,
                "sequence_org": "C",
                "sequence_mut": "S",
                "comment": "Almost complete loss of expression of GP1 and GP2. Complete loss of virus capability to enter into host cell.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q05320",
                        "url": "https://www.uniprot.org/uniprotkb/Q05320"
                    },
                    {
                        "database": "PubMed",
                        "id": "12438572",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12438572"
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                ],
                "uniprot_canonical_ac": "Q05320-1"
            },
            {
                "start_pos": 147,
                "end_pos": 147,
                "sequence_org": "C",
                "sequence_mut": "S",
                "comment": "Reduced levels of expression of GP1 and GP2. Almost complete loss of virus capability to enter into host cell.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q05320",
                        "url": "https://www.uniprot.org/uniprotkb/Q05320"
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                    {
                        "database": "PubMed",
                        "id": "12438572",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12438572"
                    }
                ],
                "uniprot_canonical_ac": "Q05320-1"
            },
            {
                "start_pos": 204,
                "end_pos": 204,
                "sequence_org": "N",
                "sequence_mut": "D",
                "comment": "No effect on GP1 and GP2 expression. No loss of virus capability to enter into host cell.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q05320",
                        "url": "https://www.uniprot.org/uniprotkb/Q05320"
                    },
                    {
                        "database": "PubMed",
                        "id": "12438572",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12438572"
                    }
                ],
                "uniprot_canonical_ac": "Q05320-1"
            },
            {
                "start_pos": 238,
                "end_pos": 238,
                "sequence_org": "N",
                "sequence_mut": "Y",
                "comment": "No effect on GP1 and GP2 expression. 12% loss of virus capability to enter into host cell.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q05320",
                        "url": "https://www.uniprot.org/uniprotkb/Q05320"
                    },
                    {
                        "database": "PubMed",
                        "id": "12438572",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12438572"
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                ],
                "uniprot_canonical_ac": "Q05320-1"
            },
            {
                "start_pos": 257,
                "end_pos": 257,
                "sequence_org": "N",
                "sequence_mut": "D",
                "comment": "No effect on GP1 and GP2 expression. 12% loss of virus capability to enter into host cell.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q05320",
                        "url": "https://www.uniprot.org/uniprotkb/Q05320"
                    },
                    {
                        "database": "PubMed",
                        "id": "12438572",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12438572"
                    }
                ],
                "uniprot_canonical_ac": "Q05320-1"
            },
            {
                "start_pos": 296,
                "end_pos": 296,
                "sequence_org": "N",
                "sequence_mut": "D",
                "comment": "No effect on GP1 and GP2 expression. 18% loss of virus capability to enter into host cell.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q05320",
                        "url": "https://www.uniprot.org/uniprotkb/Q05320"
                    },
                    {
                        "database": "PubMed",
                        "id": "12438572",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12438572"
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                "uniprot_canonical_ac": "Q05320-1"
            },
            {
                "start_pos": 40,
                "end_pos": 40,
                "sequence_org": "N",
                "sequence_mut": "D",
                "comment": "Induces GP1 secretion. Complete loss of virus capability to enter into host cell.",
                "evidence": [
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                        "database": "UniProtKB",
                        "id": "Q05320",
                        "url": "https://www.uniprot.org/uniprotkb/Q05320"
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                        "database": "PubMed",
                        "id": "12438572",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12438572"
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                ],
                "uniprot_canonical_ac": "Q05320-1"
            },
            {
                "start_pos": 511,
                "end_pos": 511,
                "sequence_org": "C",
                "sequence_mut": "G",
                "comment": "Induces GP1 secretion. Complete loss of virus capability to enter into host cell.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q05320",
                        "url": "https://www.uniprot.org/uniprotkb/Q05320"
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                        "database": "PubMed",
                        "id": "12438572",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12438572"
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                ],
                "uniprot_canonical_ac": "Q05320-1"
            },
            {
                "start_pos": 53,
                "end_pos": 53,
                "sequence_org": "C",
                "sequence_mut": "G",
                "comment": "Induces GP1 secretion. Complete loss of virus capability to enter into host cell.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q05320",
                        "url": "https://www.uniprot.org/uniprotkb/Q05320"
                    },
                    {
                        "database": "PubMed",
                        "id": "12438572",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12438572"
                    }
                ],
                "uniprot_canonical_ac": "Q05320-1"
            },
            {
                "start_pos": 556,
                "end_pos": 556,
                "sequence_org": "C",
                "sequence_mut": "S",
                "comment": "Induces GP1 secretion. Complete loss of virus capability to enter into host cell.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q05320",
                        "url": "https://www.uniprot.org/uniprotkb/Q05320"
                    },
                    {
                        "database": "PubMed",
                        "id": "12438572",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12438572"
                    }
                ],
                "uniprot_canonical_ac": "Q05320-1"
            },
            {
                "start_pos": 563,
                "end_pos": 563,
                "sequence_org": "N",
                "sequence_mut": "D",
                "comment": "Reduced levels of expression of GP, GP1 and GP2. 20% loss of virus capability to enter into host cell.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q05320",
                        "url": "https://www.uniprot.org/uniprotkb/Q05320"
                    },
                    {
                        "database": "PubMed",
                        "id": "12438572",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12438572"
                    }
                ],
                "uniprot_canonical_ac": "Q05320-1"
            },
            {
                "start_pos": 601,
                "end_pos": 601,
                "sequence_org": "C",
                "sequence_mut": "S",
                "comment": "Induces GP1 secretion. Complete loss of virus capability to enter into host cell.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q05320",
                        "url": "https://www.uniprot.org/uniprotkb/Q05320"
                    },
                    {
                        "database": "PubMed",
                        "id": "12438572",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12438572"
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                ],
                "uniprot_canonical_ac": "Q05320-1"
            },
            {
                "start_pos": 608,
                "end_pos": 608,
                "sequence_org": "C",
                "sequence_mut": "G",
                "comment": "Induces GP1 secretion. Complete loss of virus capability to enter into host cell.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q05320",
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                        "database": "PubMed",
                        "id": "12438572",
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                ],
                "uniprot_canonical_ac": "Q05320-1"
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            {
                "start_pos": 609,
                "end_pos": 609,
                "sequence_org": "C",
                "sequence_mut": "G",
                "comment": "Induces GP1 secretion. Complete loss of virus capability to enter into host cell.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q05320",
                        "url": "https://www.uniprot.org/uniprotkb/Q05320"
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                    {
                        "database": "PubMed",
                        "id": "12438572",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12438572"
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                ],
                "uniprot_canonical_ac": "Q05320-1"
            },
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                "start_pos": 618,
                "end_pos": 618,
                "sequence_org": "N",
                "sequence_mut": "D",
                "comment": "Slightly reduced levels of expression of GP1 and GP2. No loss of virus capability to enter into host cell.",
                "evidence": [
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                        "id": "Q05320",
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                "start_pos": 670,
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                "sequence_org": "C",
                "sequence_mut": "A",
                "comment": "Reduced palmitoylation. No effect on GP processing and association with retrovirus particle. No loss of virus capability to enter into host cell. Loss of localization to the rafts; when associated with A-670.",
                "evidence": [
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                "comment": "Slightly reduced levels of expression of GP1 and GP2. Greatly reduced GP processing and association with retrovirus particle. 43% loss of virus capability to enter into host cell. Loss of localization to the rafts; when associated with A-672.",
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                "comment": "Reduced palmitoylation. No effect on GP processing and association with retrovirus particle. No loss of virus capability to enter into host cell.",
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                "comment": "Slightly reduced levels of expression of GP1 and GP2. Almost no effect on GP processing and association with retrovirus particle. 24% loss of virus capability to enter into host cell.",
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    {
        "title": "DC-SIGN and DC-SIGNR bind ebola glycoproteins and enhance infection of macrophages and endothelial cells.",
        "journal": "Virology",
        "date": "2003",
        "authors": "Simmons Graham, Reeves Jacqueline D, Grogan Case C, Vandenberghe Luk H, Baribaud Fr\u00e9d\u00e9ric, Whitbeck J Charles, Burke Emily, Buchmeier Michael J, Soilleux Elizabeth J, Riley James L, Doms Robert W, Bates Paul, P\u00f6hlmann Stefan",
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                        "field": "n_linked_glycans",
                        "count": 0
                    },
                    {
                        "field": "o_linked_glycans",
                        "count": 0
                    }
                ],
                "sort_fields": []
            }
        ]
    }
]
