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"gene_name": "PRKCQ", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60725-1", "protein_name": "Protein-S-isoprenylcysteine O-methyltransferase", "gene_name": "ICMT", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01116-1", "protein_name": "GTPase KRas", "gene_name": "KRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6R6M4-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 17", "gene_name": "USP17L2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49356-1", "protein_name": "Protein farnesyltransferase subunit beta", "gene_name": "FNTB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y256-1", "protein_name": "CAAX prenyl protease 2", "gene_name": "RCE1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VST6-1", "protein_name": "Alpha/beta hydrolase domain-containing protein 17B", "gene_name": "ABHD17B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PCB6-1", "protein_name": "Alpha/beta hydrolase domain-containing protein 17C", "gene_name": "ABHD17C", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43924", "url": "https://www.uniprot.org/uniprotkb/O43924" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10667208", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 24 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", 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], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Human ras-converting enzyme (hRCE1) endoproteolytic activity on K-ras-derived peptides.", "journal": "Analytical biochemistry", "date": "2000", "authors": "Hollander I, Frommer E, Mallon R", "reference": { "type": "PubMed", "id": "11038283", "url": "https://pubmed.ncbi.nlm.nih.gov/11038283" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43924-1", "protein_name": "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "gene_name": "PDE6D", 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"gene_name": "ABHD17C", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43924", "url": "https://www.uniprot.org/uniprotkb/O43924" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11038283", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 24 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { 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}, { "uniprot_canonical_ac": "Q13237-1", "protein_name": "cGMP-dependent protein kinase 2", "gene_name": "PRKG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01111-1", "protein_name": "GTPase NRas", "gene_name": "NRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q07817-1", "protein_name": "Bcl-2-like protein 1", "gene_name": "BCL2L1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0DP23-1", "protein_name": "Calmodulin-1", "gene_name": "CALM1; CALM2; CALM3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75608-1", "protein_name": "Acyl-protein thioesterase 1", "gene_name": "LYPLA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y397-1", "protein_name": "Palmitoyltransferase ZDHHC9", "gene_name": "ZDHHC9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96GS6-1", "protein_name": "Alpha/beta hydrolase domain-containing protein 17A", "gene_name": "ABHD17A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7Z5G4-1", "protein_name": "Golgin subfamily A member 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"uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y256-1", "protein_name": "CAAX prenyl protease 2", "gene_name": "RCE1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VST6-1", "protein_name": "Alpha/beta hydrolase domain-containing protein 17B", "gene_name": "ABHD17B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PCB6-1", "protein_name": "Alpha/beta hydrolase domain-containing protein 17C", "gene_name": "ABHD17C", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43924", "url": "https://www.uniprot.org/uniprotkb/O43924" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11585916", 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"Carboxyl methylation of Ras regulates membrane targeting and effector engagement.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Chiu VK, Silletti J, Dinsell V, Wiener H, Loukeris K, Ou G, Philips MR, Pillinger MH", "reference": { "type": "PubMed", "id": "14660603", "url": "https://pubmed.ncbi.nlm.nih.gov/14660603" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43924-1", "protein_name": "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "gene_name": "PDE6D", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36404-1", "protein_name": "ADP-ribosylation factor-like protein 2", "gene_name": "ARL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49354-1", "protein_name": "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha", "gene_name": "FNTA", 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proper localization of Ras but not Rho GTPases.", "journal": "Molecular biology of the cell", "date": "2005", "authors": "Michaelson D, Ali W, Chiu VK, Bergo M, Silletti J, Wright L, Young SG, Philips M", "reference": { "type": "PubMed", "id": "15659645", "url": "https://pubmed.ncbi.nlm.nih.gov/15659645" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43924-1", "protein_name": "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "gene_name": "PDE6D", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36404-1", "protein_name": "ADP-ribosylation factor-like protein 2", "gene_name": "ARL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49354-1", "protein_name": "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha", "gene_name": "FNTA", "tax_name": "Human" }, { "uniprot_canonical_ac": 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"count": 0 } ], "sort_fields": [] } ] }, { "title": "Reversible intracellular translocation of KRas but not HRas in hippocampal neurons regulated by Ca2+/calmodulin.", "journal": "The Journal of cell biology", "date": "2005", "authors": "Fivaz M, Meyer T", "reference": { "type": "PubMed", "id": "16043511", "url": "https://pubmed.ncbi.nlm.nih.gov/16043511" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43924-1", "protein_name": "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "gene_name": "PDE6D", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36404-1", "protein_name": "ADP-ribosylation factor-like protein 2", "gene_name": "ARL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49354-1", "protein_name": "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha", "gene_name": 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"protein_name": "Protein kinase C theta type", "gene_name": "PRKCQ", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60725-1", "protein_name": "Protein-S-isoprenylcysteine O-methyltransferase", "gene_name": "ICMT", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01116-1", "protein_name": "GTPase KRas", "gene_name": "KRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6R6M4-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 17", "gene_name": "USP17L2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49356-1", "protein_name": "Protein farnesyltransferase subunit beta", "gene_name": "FNTB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y256-1", "protein_name": "CAAX prenyl protease 2", "gene_name": 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isoprenylcysteine carboxylmethyltransferase induces autophagic-dependent apoptosis and impairs tumor growth.", "journal": "Oncogene", "date": "2010", "authors": "Wang M, Hossain MS, Tan W, Coolman B, Zhou J, Liu S, Casey PJ", "reference": { "type": "PubMed", "id": "20622895", "url": "https://pubmed.ncbi.nlm.nih.gov/20622895" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43924-1", "protein_name": "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "gene_name": "PDE6D", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36404-1", "protein_name": "ADP-ribosylation factor-like protein 2", "gene_name": "ARL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49354-1", "protein_name": "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha", "gene_name": "FNTA", "tax_name": "Human" }, { 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"RCE1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VST6-1", "protein_name": "Alpha/beta hydrolase domain-containing protein 17B", "gene_name": "ABHD17B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PCB6-1", "protein_name": "Alpha/beta hydrolase domain-containing protein 17C", "gene_name": "ABHD17C", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43924", "url": "https://www.uniprot.org/uniprotkb/O43924" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.20802526", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 24 } ], "sort_fields": [ 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"name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43924", "url": "https://www.uniprot.org/uniprotkb/O43924" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.21905185", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 24 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, 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"count": 0 } ], "sort_fields": [] } ] }, { "title": "Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2011", "authors": "Rusch M, Zimmermann TJ, Burger M, Dekker FJ, Gormer K, Triola G, Brockmeyer A, Janning P, Bottcher T, Sieber SA, Vetter IR, Hedberg C, Waldmann H", "reference": { "type": "PubMed", "id": "21905186", "url": "https://pubmed.ncbi.nlm.nih.gov/21905186" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43924-1", "protein_name": "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "gene_name": "PDE6D", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36404-1", "protein_name": "ADP-ribosylation factor-like protein 2", "gene_name": "ARL2", 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cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras.", "journal": "Blood", "date": "2012", "authors": "Xu J, Hedberg C, Dekker FJ, Li Q, Haigis KM, Hwang E, Waldmann H, Shannon K", "reference": { "type": "PubMed", "id": "22144181", "url": "https://pubmed.ncbi.nlm.nih.gov/22144181" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43924-1", "protein_name": "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "gene_name": "PDE6D", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36404-1", "protein_name": "ADP-ribosylation factor-like protein 2", "gene_name": "ARL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49354-1", "protein_name": "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha", "gene_name": "FNTA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13237-1", "protein_name": "cGMP-dependent protein kinase 2", "gene_name": "PRKG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01111-1", "protein_name": "GTPase NRas", "gene_name": "NRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q07817-1", "protein_name": "Bcl-2-like protein 1", "gene_name": "BCL2L1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0DP23-1", "protein_name": "Calmodulin-1", "gene_name": "CALM1; CALM2; CALM3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75608-1", "protein_name": "Acyl-protein thioesterase 1", "gene_name": "LYPLA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y397-1", "protein_name": "Palmitoyltransferase ZDHHC9", "gene_name": "ZDHHC9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96GS6-1", "protein_name": "Alpha/beta hydrolase domain-containing protein 17A", "gene_name": "ABHD17A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7Z5G4-1", "protein_name": "Golgin subfamily A member 7", "gene_name": "GOLGA7", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04759-1", "protein_name": "Protein kinase C theta type", "gene_name": "PRKCQ", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60725-1", "protein_name": "Protein-S-isoprenylcysteine O-methyltransferase", "gene_name": "ICMT", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01116-1", "protein_name": "GTPase KRas", "gene_name": "KRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6R6M4-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 17", "gene_name": "USP17L2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49356-1", "protein_name": "Protein farnesyltransferase subunit beta", "gene_name": "FNTB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y256-1", "protein_name": "CAAX prenyl protease 2", "gene_name": "RCE1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VST6-1", "protein_name": "Alpha/beta hydrolase domain-containing protein 17B", "gene_name": "ABHD17B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PCB6-1", "protein_name": "Alpha/beta hydrolase domain-containing protein 17C", "gene_name": "ABHD17C", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43924", "url": "https://www.uniprot.org/uniprotkb/O43924" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.22144181", 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Ismail SA, Hedberg C, Hanzal-Bayer M, Venkitaraman AR, Wittinghofer A, Bastiaens PI", "reference": { "type": "PubMed", "id": "22179043", "url": "https://pubmed.ncbi.nlm.nih.gov/22179043" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43924-1", "protein_name": "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "gene_name": "PDE6D", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36404-1", "protein_name": "ADP-ribosylation factor-like protein 2", "gene_name": "ARL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O55057-1", "protein_name": "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "gene_name": "Pde6d", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "P49354-1", "protein_name": "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha", 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[9606]" } ], "record_id": "pubmed.22179043", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 25 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 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Manolaridis I, Zhang Z, Dodd RB, Mas-Droux C, Barford D", "reference": { "type": "PubMed", "id": "22195972", "url": "https://pubmed.ncbi.nlm.nih.gov/22195972" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43924-1", "protein_name": "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "gene_name": "PDE6D", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36404-1", "protein_name": "ADP-ribosylation factor-like protein 2", "gene_name": "ARL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49354-1", "protein_name": "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha", "gene_name": "FNTA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H479-1", "protein_name": "Fructosamine-3-kinase", "gene_name": "FN3K", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13237-1", "protein_name": "cGMP-dependent protein kinase 2", "gene_name": "PRKG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01111-1", "protein_name": "GTPase NRas", "gene_name": "NRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q07817-1", "protein_name": "Bcl-2-like protein 1", "gene_name": "BCL2L1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0DP23-1", "protein_name": "Calmodulin-1", "gene_name": "CALM1; CALM2; CALM3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75608-1", "protein_name": "Acyl-protein thioesterase 1", "gene_name": "LYPLA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y397-1", "protein_name": "Palmitoyltransferase ZDHHC9", "gene_name": "ZDHHC9", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00451-1", "protein_name": "Coagulation factor VIII", "gene_name": "F8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96GS6-1", "protein_name": "Alpha/beta hydrolase domain-containing protein 17A", "gene_name": "ABHD17A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7Z5G4-1", "protein_name": "Golgin subfamily A member 7", "gene_name": "GOLGA7", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04759-1", "protein_name": "Protein kinase C theta type", "gene_name": "PRKCQ", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HA64-1", "protein_name": "Ketosamine-3-kinase", "gene_name": "FN3KRP", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60725-1", "protein_name": "Protein-S-isoprenylcysteine O-methyltransferase", "gene_name": "ICMT", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01116-1", "protein_name": "GTPase KRas", "gene_name": "KRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60507-1", "protein_name": "Protein-tyrosine sulfotransferase 1", "gene_name": "TPST1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6R6M4-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 17", "gene_name": "USP17L2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49356-1", "protein_name": "Protein farnesyltransferase subunit beta", "gene_name": "FNTB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y256-1", "protein_name": "CAAX prenyl protease 2", "gene_name": "RCE1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60704-1", "protein_name": "Protein-tyrosine sulfotransferase 2", "gene_name": "TPST2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VST6-1", "protein_name": "Alpha/beta hydrolase domain-containing protein 17B", "gene_name": "ABHD17B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PCB6-1", "protein_name": "Alpha/beta hydrolase 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"protein_name": "Palmitoyltransferase ZDHHC9", "gene_name": "ZDHHC9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96GS6-1", "protein_name": "Alpha/beta hydrolase domain-containing protein 17A", "gene_name": "ABHD17A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7Z5G4-1", "protein_name": "Golgin subfamily A member 7", "gene_name": "GOLGA7", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04759-1", "protein_name": "Protein kinase C theta type", "gene_name": "PRKCQ", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60725-1", "protein_name": "Protein-S-isoprenylcysteine O-methyltransferase", "gene_name": "ICMT", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01116-1", "protein_name": "GTPase KRas", "gene_name": "KRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6R6M4-1", "protein_name": "Ubiquitin 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"gene_name": "UBC", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43924", "url": "https://www.uniprot.org/uniprotkb/O43924" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.22721555", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 24 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", 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"count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt).", "journal": "European journal of medicinal chemistry", "date": "2013", "authors": "Ramanujulu PM, Yang T, Yap SQ, Wong FC, Casey PJ, Wang M, Go ML", "reference": { "type": "PubMed", "id": "23514631", "url": "https://pubmed.ncbi.nlm.nih.gov/23514631" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43924-1", "protein_name": "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "gene_name": "PDE6D", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36404-1", "protein_name": "ADP-ribosylation factor-like protein 2", "gene_name": "ARL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49354-1", 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"uniprot_canonical_ac": "Q04759-1", "protein_name": "Protein kinase C theta type", "gene_name": "PRKCQ", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HA64-1", "protein_name": "Ketosamine-3-kinase", "gene_name": "FN3KRP", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60725-1", "protein_name": "Protein-S-isoprenylcysteine O-methyltransferase", "gene_name": "ICMT", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01116-1", "protein_name": "GTPase KRas", "gene_name": "KRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60507-1", "protein_name": "Protein-tyrosine sulfotransferase 1", "gene_name": "TPST1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6R6M4-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 17", "gene_name": "USP17L2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49356-1", "protein_name": "Protein farnesyltransferase subunit beta", "gene_name": "FNTB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y256-1", "protein_name": "CAAX prenyl protease 2", "gene_name": "RCE1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60704-1", "protein_name": "Protein-tyrosine sulfotransferase 2", "gene_name": "TPST2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VST6-1", "protein_name": "Alpha/beta hydrolase domain-containing protein 17B", "gene_name": "ABHD17B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PCB6-1", "protein_name": "Alpha/beta hydrolase domain-containing protein 17C", "gene_name": "ABHD17C", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43924", "url": "https://www.uniprot.org/uniprotkb/O43924" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.24971579", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 29 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 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the function of PDEdelta: the Proctor lecture.", "journal": "Investigative ophthalmology & visual science", "date": "2014", "authors": "Baehr W", "reference": { "type": "PubMed", "id": "25550383", "url": "https://pubmed.ncbi.nlm.nih.gov/25550383" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43924-1", "protein_name": "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "gene_name": "PDE6D", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36404-1", "protein_name": "ADP-ribosylation factor-like protein 2", "gene_name": "ARL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49354-1", "protein_name": "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha", "gene_name": "FNTA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13237-1", "protein_name": "cGMP-dependent protein kinase 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"uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43924", "url": "https://www.uniprot.org/uniprotkb/O43924" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.25759176", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 24 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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"glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization.", "journal": "eLife", "date": "2015", "authors": "Lin DT, Conibear E", "reference": { "type": "PubMed", "id": "26701913", "url": "https://pubmed.ncbi.nlm.nih.gov/26701913" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43924-1", "protein_name": "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "gene_name": "PDE6D", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36404-1", "protein_name": "ADP-ribosylation factor-like protein 2", "gene_name": "ARL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49354-1", "protein_name": "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha", "gene_name": "FNTA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13237-1", "protein_name": "cGMP-dependent protein kinase 2", "gene_name": "PRKG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01111-1", "protein_name": "GTPase NRas", "gene_name": "NRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q07817-1", "protein_name": "Bcl-2-like protein 1", "gene_name": "BCL2L1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0DP23-1", "protein_name": "Calmodulin-1", "gene_name": "CALM1; CALM2; CALM3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75608-1", "protein_name": "Acyl-protein thioesterase 1", "gene_name": "LYPLA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P78352-1", "protein_name": "Disks large homolog 4", "gene_name": "DLG4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y397-1", "protein_name": "Palmitoyltransferase ZDHHC9", "gene_name": "ZDHHC9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96GS6-1", "protein_name": "Alpha/beta hydrolase domain-containing protein 17A", "gene_name": "ABHD17A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7Z5G4-1", "protein_name": "Golgin subfamily A member 7", "gene_name": "GOLGA7", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04759-1", "protein_name": "Protein kinase C theta type", "gene_name": "PRKCQ", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60725-1", "protein_name": "Protein-S-isoprenylcysteine O-methyltransferase", "gene_name": "ICMT", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01116-1", "protein_name": "GTPase KRas", "gene_name": "KRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6R6M4-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 17", "gene_name": "USP17L2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49356-1", "protein_name": "Protein farnesyltransferase subunit beta", "gene_name": "FNTB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y256-1", "protein_name": "CAAX prenyl protease 2", "gene_name": "RCE1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VST6-1", "protein_name": "Alpha/beta hydrolase domain-containing protein 17B", "gene_name": "ABHD17B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PCB6-1", "protein_name": "Alpha/beta hydrolase domain-containing protein 17C", "gene_name": "ABHD17C", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43924", "url": "https://www.uniprot.org/uniprotkb/O43924" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 181, "end_pos": 181, "sequence_org": "C", "sequence_mut": "S", "comment": "Loss of plasma membrane localization.", "evidence": [ { "database": "UniProtKB", "id": "P01111", "url": "https://www.uniprot.org/uniprotkb/P01111" }, { "database": "PubMed", "id": "26701913", "url": "https://pubmed.ncbi.nlm.nih.gov/26701913" } ], "uniprot_canonical_ac": "P01111-1" }, { "start_pos": 190, "end_pos": 190, "sequence_org": "S", "sequence_mut": "A", "comment": "Loss of catalytic activity. No effect on its localization. No effect on NRAS plasma membrane localization.", "evidence": [ { "database": "UniProtKB", "id": "Q96GS6", "url": "https://www.uniprot.org/uniprotkb/Q96GS6" }, { "database": "PubMed", "id": "26701913", "url": "https://pubmed.ncbi.nlm.nih.gov/26701913" } ], "uniprot_canonical_ac": "Q96GS6-1" }, { "start_pos": 1, "end_pos": 19, "sequence_org": "MNGLSLSELCCLFCCPPCP", "sequence_mut": "", "comment": "Reduces catalytic activity. Loss of membrane localization. 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"o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Inhibition of isoprenylcysteine carboxylmethyltransferase augments BCR-ABL1 tyrosine kinase inhibition-induced apoptosis in chronic myeloid leukemia.", "journal": "Experimental hematology", "date": "2016", "authors": "Sun WT, Xiang W, Ng BL, Asari K, Bunte RM, Casey PJ, Wang M, Chuah C", "reference": { "type": "PubMed", "id": "26706195", "url": "https://pubmed.ncbi.nlm.nih.gov/26706195" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43924-1", "protein_name": "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "gene_name": "PDE6D", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36404-1", "protein_name": "ADP-ribosylation factor-like protein 2", "gene_name": "ARL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49354-1", 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APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells.", "journal": "Oncotarget", "date": "2016", "authors": "Vujic I, Sanlorenzo M, Esteve-Puig R, Vujic M, Kwong A, Tsumura A, Murphy R, Moy A, Posch C, Monshi B, Rappersberger K, Ortiz-Urda S", "reference": { "type": "PubMed", "id": "26771141", "url": "https://pubmed.ncbi.nlm.nih.gov/26771141" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43924-1", "protein_name": "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "gene_name": "PDE6D", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36404-1", "protein_name": "ADP-ribosylation factor-like protein 2", "gene_name": "ARL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49354-1", "protein_name": "Protein farnesyltransferase/geranylgeranyltransferase type-1 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"authors": "Casey PJ, Solski PA, Der CJ, Buss JE", "reference": { "type": "PubMed", "id": "2682646", "url": "https://pubmed.ncbi.nlm.nih.gov/2682646" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43924-1", "protein_name": "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "gene_name": "PDE6D", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36404-1", "protein_name": "ADP-ribosylation factor-like protein 2", "gene_name": "ARL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49354-1", "protein_name": "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha", "gene_name": "FNTA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13237-1", "protein_name": "cGMP-dependent protein kinase 2", "gene_name": "PRKG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01111-1", 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"AMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions via Cyclic GMP-Dependent Protein Kinase 2.", "journal": "Molecular and cellular biology", "date": "2016", "authors": "Cho KJ, Casteel DE, Prakash P, Tan L, van der Hoeven D, Salim AA, Kim C, Capon RJ, Lacey E, Cunha SR, Gorfe AA, Hancock JF", "reference": { "type": "PubMed", "id": "27697864", "url": "https://pubmed.ncbi.nlm.nih.gov/27697864" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43924-1", "protein_name": "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "gene_name": "PDE6D", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36404-1", "protein_name": "ADP-ribosylation factor-like protein 2", "gene_name": "ARL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49354-1", "protein_name": "Protein 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National Academy of Sciences of the United States of America", "date": "2016", "authors": "Dharmaiah S, Bindu L, Tran TH, Gillette WK, Frank PH, Ghirlando R, Nissley DV, Esposito D, McCormick F, Stephen AG, Simanshu DK", "reference": { "type": "PubMed", "id": "27791178", "url": "https://pubmed.ncbi.nlm.nih.gov/27791178" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43924-1", "protein_name": "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "gene_name": "PDE6D", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36404-1", "protein_name": "ADP-ribosylation factor-like protein 2", "gene_name": "ARL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49354-1", "protein_name": "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha", "gene_name": "FNTA", "tax_name": "Human" }, { 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"count": 0 } ], "sort_fields": [] } ] }, { "title": "Rce1: mechanism and inhibition.", "journal": "Critical reviews in biochemistry and molecular biology", "date": "2018", "authors": "Hampton SE, Dore TM, Schmidt WK", "reference": { "type": "PubMed", "id": "29424242", "url": "https://pubmed.ncbi.nlm.nih.gov/29424242" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43924-1", "protein_name": "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "gene_name": "PDE6D", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36404-1", "protein_name": "ADP-ribosylation factor-like protein 2", "gene_name": "ARL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49354-1", "protein_name": "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha", "gene_name": "FNTA", "tax_name": "Human" }, { 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"uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y256-1", "protein_name": "CAAX prenyl protease 2", "gene_name": "RCE1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VST6-1", "protein_name": "Alpha/beta hydrolase domain-containing protein 17B", "gene_name": "ABHD17B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PCB6-1", "protein_name": "Alpha/beta hydrolase domain-containing protein 17C", "gene_name": "ABHD17C", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43924", "url": "https://www.uniprot.org/uniprotkb/O43924" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.29424242", 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"uniprot_canonical_ac": "P01111-1", "protein_name": "GTPase NRas", "gene_name": "NRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q460N5-6", "protein_name": "Protein mono-ADP-ribosyltransferase PARP14", "gene_name": "PARP14", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UKK3-1", "protein_name": "Protein mono-ADP-ribosyltransferase PARP4", "gene_name": "PARP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N5Y8-1", "protein_name": "Protein mono-ADP-ribosyltransferase PARP16", "gene_name": "PARP16", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q07817-1", "protein_name": "Bcl-2-like protein 1", "gene_name": "BCL2L1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0DP23-1", "protein_name": "Calmodulin-1", "gene_name": "CALM1; CALM2; CALM3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75608-1", "protein_name": "Acyl-protein thioesterase 1", "gene_name": "LYPLA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y397-1", "protein_name": "Palmitoyltransferase ZDHHC9", "gene_name": "ZDHHC9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q2NL67-1", "protein_name": "Protein mono-ADP-ribosyltransferase PARP6", "gene_name": "PARP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N3A8-1", "protein_name": "Protein mono-ADP-ribosyltransferase PARP8", "gene_name": "PARP8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IXQ6-1", "protein_name": "Protein mono-ADP-ribosyltransferase PARP9", "gene_name": "PARP9", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49841-1", "protein_name": "Glycogen synthase kinase-3 beta", "gene_name": "GSK3B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96GS6-1", "protein_name": "Alpha/beta hydrolase domain-containing protein 17A", "gene_name": "ABHD17A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63279-1", "protein_name": "SUMO-conjugating enzyme UBC9", "gene_name": "UBE2I", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99873-1", "protein_name": "Protein arginine N-methyltransferase 1", "gene_name": "PRMT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7Z5G4-1", "protein_name": "Golgin subfamily A member 7", "gene_name": "GOLGA7", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63165-1", "protein_name": "Small ubiquitin-related modifier 1", "gene_name": "SUMO1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04759-1", "protein_name": "Protein kinase C theta type", "gene_name": "PRKCQ", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49840-1", "protein_name": "Glycogen synthase kinase-3 alpha", "gene_name": "GSK3A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96SB4-2", "protein_name": "SRSF protein kinase 1", "gene_name": "SRPK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60725-1", "protein_name": "Protein-S-isoprenylcysteine O-methyltransferase", "gene_name": 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{ "field": "total", "count": 39 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Validation of a small molecule inhibitor of PDE6D-RAS interaction with favorable anti-leukemic effects.", "journal": "Blood cancer journal", "date": "2022", "authors": "Canovas Nunes S, De Vita S, Anighoro A, Autelitano F, Beaumont E, Klingbeil P, McGuinness M, Duvert B, Harris C, Yang L, Pokharel SP, Chen CW, Ermann M, Williams DA, Xu H", "reference": { "type": "PubMed", "id": "35422065", "url": 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"uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36404-1", "protein_name": "ADP-ribosylation factor-like protein 2", "gene_name": "ARL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49354-1", "protein_name": "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha", "gene_name": "FNTA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13237-1", "protein_name": "cGMP-dependent protein kinase 2", "gene_name": "PRKG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01111-1", "protein_name": "GTPase NRas", "gene_name": "NRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q07817-1", "protein_name": "Bcl-2-like protein 1", "gene_name": "BCL2L1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0DP23-1", "protein_name": "Calmodulin-1", "gene_name": "CALM1; CALM2; CALM3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75608-1", "protein_name": "Acyl-protein thioesterase 1", "gene_name": "LYPLA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y397-1", "protein_name": "Palmitoyltransferase ZDHHC9", "gene_name": "ZDHHC9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96GS6-1", "protein_name": "Alpha/beta hydrolase domain-containing protein 17A", "gene_name": "ABHD17A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7Z5G4-1", "protein_name": "Golgin subfamily A member 7", "gene_name": "GOLGA7", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04759-1", "protein_name": "Protein kinase C theta type", "gene_name": "PRKCQ", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60725-1", "protein_name": "Protein-S-isoprenylcysteine O-methyltransferase", "gene_name": "ICMT", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01116-1", "protein_name": "GTPase KRas", "gene_name": "KRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6R6M4-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 17", "gene_name": "USP17L2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49356-1", "protein_name": "Protein farnesyltransferase subunit beta", "gene_name": "FNTB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y256-1", "protein_name": "CAAX prenyl protease 2", "gene_name": "RCE1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VST6-1", "protein_name": "Alpha/beta hydrolase domain-containing protein 17B", "gene_name": "ABHD17B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PCB6-1", "protein_name": "Alpha/beta hydrolase domain-containing protein 17C", "gene_name": "ABHD17C", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43924", "url": "https://www.uniprot.org/uniprotkb/O43924" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.9436858", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 24 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": 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Cell Genet.", "date": "1997", "authors": "Ershova G, Derr\u00e9 J, Ch\u00e9telin S, Nancy V, Berger R, Kaplan J, Munnich A, de Gunzburg J", "reference": { "type": "PubMed", "id": "9533031", "url": "https://pubmed.ncbi.nlm.nih.gov/9533031" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43924-1", "protein_name": "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "gene_name": "PDE6D", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43924", "url": "https://www.uniprot.org/uniprotkb/O43924" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.9533031", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], 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"count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Characterization of human and mouse rod cGMP phosphodiesterase delta subunit (PDE6D) and chromosomal localization of the human gene.", "journal": "Genomics", "date": "1998", "authors": "Li N, Florio S K, Pettenati M J, Rao P N, Beavo J A, Baehr W", "reference": { "type": "PubMed", "id": "9570951", "url": "https://pubmed.ncbi.nlm.nih.gov/9570951" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43924-1", 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"Ras-related protein Rab-13", "gene_name": "RAB13", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43924", "url": "https://www.uniprot.org/uniprotkb/O43924" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.9712853", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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"count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Cloning and gene structure of the rod cGMP phosphodiesterase delta subunit gene (PDED) in man and mouse.", "journal": "Eur. J. Hum. Genet.", "date": "1998", "authors": "Lorenz B, Migliaccio C, Lichtner P, Meyer C, Strom TM, D'Urso M, Becker J, Ciccodicola A, Meitinger T", "reference": { "type": "PubMed", "id": "9781033", "url": "https://pubmed.ncbi.nlm.nih.gov/9781033" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43924-1", "protein_name": "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "gene_name": "PDE6D", "tax_name": "Human" }, { "uniprot_canonical_ac": "O55057-1", "protein_name": "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "gene_name": "Pde6d", "tax_name": "Mouse" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43924", "url": "https://www.uniprot.org/uniprotkb/O43924" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.9781033", "abstract": "", "glycosylation": [], 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"o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice.", "journal": "Cancer research", "date": "1998", "authors": "Liu M, Bryant MS, Chen J, Lee S, Yaremko B, Lipari P, Malkowski M, Ferrari E, Nielsen L, Prioli N, Dell J, Sinha D, Syed J, Korfmacher WA, Nomeir AA, Lin CC, Wang L, Taveras AG, Doll RJ, Njoroge FG, Mallams AK, Remiszewski S, Catino JJ, Girijavallabhan VM, Bishop WR, et al.", "reference": { "type": "PubMed", "id": "9810004", "url": "https://pubmed.ncbi.nlm.nih.gov/9810004" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43924-1", "protein_name": "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "gene_name": "PDE6D", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36404-1", "protein_name": "ADP-ribosylation factor-like protein 2", "gene_name": "ARL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49354-1", "protein_name": "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha", "gene_name": "FNTA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13237-1", "protein_name": "cGMP-dependent protein kinase 2", "gene_name": "PRKG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01111-1", "protein_name": "GTPase NRas", "gene_name": "NRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q07817-1", "protein_name": "Bcl-2-like protein 1", "gene_name": "BCL2L1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0DP23-1", "protein_name": "Calmodulin-1", "gene_name": "CALM1; CALM2; CALM3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75608-1", "protein_name": "Acyl-protein thioesterase 1", "gene_name": "LYPLA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y397-1", "protein_name": "Palmitoyltransferase ZDHHC9", "gene_name": "ZDHHC9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96GS6-1", "protein_name": "Alpha/beta hydrolase domain-containing protein 17A", "gene_name": "ABHD17A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7Z5G4-1", "protein_name": "Golgin subfamily A member 7", "gene_name": "GOLGA7", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04759-1", "protein_name": "Protein kinase C theta type", "gene_name": "PRKCQ", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60725-1", "protein_name": "Protein-S-isoprenylcysteine O-methyltransferase", "gene_name": "ICMT", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01116-1", "protein_name": "GTPase KRas", "gene_name": "KRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6R6M4-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 17", "gene_name": "USP17L2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49356-1", "protein_name": "Protein farnesyltransferase subunit beta", "gene_name": "FNTB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y256-1", "protein_name": "CAAX prenyl protease 2", "gene_name": "RCE1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VST6-1", "protein_name": "Alpha/beta hydrolase domain-containing protein 17B", "gene_name": "ABHD17B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PCB6-1", "protein_name": "Alpha/beta hydrolase domain-containing protein 17C", "gene_name": "ABHD17C", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43924", "url": "https://www.uniprot.org/uniprotkb/O43924" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.9810004", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 24 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "(+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5, 6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamid e (SCH-66336): a very potent farnesyl protein transferase inhibitor as a novel antitumor agent.", "journal": "Journal of medicinal chemistry", "date": "1998", "authors": "Njoroge FG, Taveras AG, Kelly J, Remiszewski S, Mallams AK, Wolin R, Afonso A, Cooper AB, Rane DF, Liu YT, Wong J, Vibulbhan B, Pinto P, Deskus J, Alvarez CS, del Rosario J, Connolly M, Wang J, Desai J, Rossman RR, Bishop WR, Patton R, Wang L, Kirschmeier P, Ganguly AK, et al.", "reference": { "type": "PubMed", "id": "9822558", "url": "https://pubmed.ncbi.nlm.nih.gov/9822558" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43924-1", "protein_name": "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "gene_name": "PDE6D", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01112-1", "protein_name": "GTPase HRas", "gene_name": "HRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36404-1", "protein_name": "ADP-ribosylation factor-like protein 2", "gene_name": "ARL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49354-1", "protein_name": "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha", "gene_name": "FNTA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13237-1", "protein_name": "cGMP-dependent protein kinase 2", "gene_name": "PRKG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01111-1", "protein_name": "GTPase NRas", "gene_name": "NRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q07817-1", "protein_name": "Bcl-2-like protein 1", "gene_name": "BCL2L1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0DP23-1", "protein_name": "Calmodulin-1", "gene_name": "CALM1; CALM2; CALM3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75608-1", "protein_name": "Acyl-protein thioesterase 1", "gene_name": "LYPLA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y397-1", "protein_name": "Palmitoyltransferase ZDHHC9", "gene_name": "ZDHHC9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96GS6-1", "protein_name": "Alpha/beta hydrolase domain-containing protein 17A", "gene_name": "ABHD17A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7Z5G4-1", "protein_name": "Golgin subfamily A member 7", "gene_name": "GOLGA7", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04759-1", "protein_name": "Protein kinase C theta type", "gene_name": "PRKCQ", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60725-1", "protein_name": "Protein-S-isoprenylcysteine O-methyltransferase", "gene_name": "ICMT", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01116-1", "protein_name": "GTPase KRas", "gene_name": "KRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6R6M4-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 17", "gene_name": "USP17L2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49356-1", "protein_name": "Protein farnesyltransferase subunit beta", "gene_name": "FNTB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y256-1", "protein_name": "CAAX prenyl protease 2", "gene_name": "RCE1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VST6-1", "protein_name": "Alpha/beta hydrolase domain-containing protein 17B", "gene_name": "ABHD17B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PCB6-1", "protein_name": "Alpha/beta hydrolase domain-containing protein 17C", "gene_name": "ABHD17C", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43924", "url": 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"uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04759-1", "protein_name": "Protein kinase C theta type", "gene_name": "PRKCQ", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60725-1", "protein_name": "Protein-S-isoprenylcysteine O-methyltransferase", "gene_name": "ICMT", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01116-1", "protein_name": "GTPase KRas", "gene_name": "KRAS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6R6M4-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 17", "gene_name": "USP17L2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49356-1", "protein_name": "Protein farnesyltransferase subunit beta", "gene_name": "FNTB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": 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Cancer Res.", "date": "2000", "authors": "Denko N, Schindler C, Koong A, Laderoute K, Green C, Giaccia A", "reference": { "type": "PubMed", "id": "10690527", "url": "https://pubmed.ncbi.nlm.nih.gov/10690527" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9Y5L2-1", "protein_name": "Hypoxia-inducible lipid droplet-associated protein", "gene_name": "HILPDA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y241-1", "protein_name": "HIG1 domain family member 1A, mitochondrial", "gene_name": "HIGD1A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9Y5L2", "url": "https://www.uniprot.org/uniprotkb/Q9Y5L2" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10690527", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": 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