[ { "title": "Heat shock factor 1, an inhibitor of non-homologous end joining repair.", "journal": "Oncotarget", "date": "2015", "authors": "Kang GY, Kim EH, Lee HJ, Gil NY, Cha HJ, Lee YS", "reference": { "type": "PubMed", "id": "26359349", "url": "https://pubmed.ncbi.nlm.nih.gov/26359349" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P12956-1", "protein_name": "DNA repair protein Ku70", "gene_name": "XRCC6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P13010-1", "protein_name": "DNA repair protein Ku80", "gene_name": "XRCC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00613-1", "protein_name": "Heat shock factor protein 1", "gene_name": "HSF1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P12956", "url": "https://www.uniprot.org/uniprotkb/P12956" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 216, "end_pos": 216, "sequence_org": "S", "sequence_mut": "A", "comment": "Does not change interaction with XRCC5 and XRCC6. No PLK1-induced phosphorylation in mitosis. Inhibits PLK1-stimulated ubiquitinylation. Increased protein stability.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "26359349", "url": "https://pubmed.ncbi.nlm.nih.gov/26359349" }, { "database": "PubMed", "id": "18794143", "url": "https://pubmed.ncbi.nlm.nih.gov/18794143" } ], "uniprot_canonical_ac": "Q00613-1" }, { "start_pos": 216, "end_pos": 216, "sequence_org": "S", "sequence_mut": "E", "comment": "Does not change interaction with XRCC5 and XRCC6. No change in spindle pole localization. Increases weakly PLK1-stimulated ubiquitinylation. No change in protein stability. Increased interaction with BTRC.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "26359349", "url": "https://pubmed.ncbi.nlm.nih.gov/26359349" }, { "database": "PubMed", "id": "18794143", "url": "https://pubmed.ncbi.nlm.nih.gov/18794143" } ], "uniprot_canonical_ac": "Q00613-1" }, { "start_pos": 298, "end_pos": 298, "sequence_org": "K", "sequence_mut": "R", "comment": "Abolishes sumoylation. No effect on phosphorylation of S-303 nor of S-307. No change in subcellular location to nuclear stress granules upon heat shock. Loss of colocalization with SUMO1 to nuclear stress granules upon heat shock. Does not change interaction with XRCC5 and XRCC6. No effect on binding to HSE nor on transactivation of HSP70. Increases transcriptional activity in a DAXX-dependent manner. No change in protein abundance.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "24581496", "url": "https://pubmed.ncbi.nlm.nih.gov/24581496" }, { "database": "PubMed", "id": "26359349", "url": "https://pubmed.ncbi.nlm.nih.gov/26359349" }, { "database": "PubMed", "id": "12665592", "url": "https://pubmed.ncbi.nlm.nih.gov/12665592" }, { "database": "PubMed", "id": "12646186", "url": "https://pubmed.ncbi.nlm.nih.gov/12646186" }, { "database": "PubMed", "id": "11514557", "url": "https://pubmed.ncbi.nlm.nih.gov/11514557" }, { "database": "PubMed", "id": "8946918", "url": "https://pubmed.ncbi.nlm.nih.gov/8946918" }, { "database": "PubMed", "id": "15016915", "url": "https://pubmed.ncbi.nlm.nih.gov/15016915" } ], "uniprot_canonical_ac": "Q00613-1" }, { "start_pos": 326, "end_pos": 326, "sequence_org": "S", "sequence_mut": "A", "comment": "No phosphorylation. Increased nuclear localization upon heat shock. No effect on oligomerization, DNA-binding activities and nuclear localization. Significant decrease in transcriptional activity by heat shock. Decreases transcriptional activity in a DAXX-dependent manner. Does not change interaction with XRCC5 and XRCC6. Weak decreased PLK1-induced phosphorylation.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "15016915", "url": "https://pubmed.ncbi.nlm.nih.gov/15016915" }, { "database": "PubMed", "id": "15760475", "url": "https://pubmed.ncbi.nlm.nih.gov/15760475" }, { "database": "PubMed", "id": "26359349", "url": "https://pubmed.ncbi.nlm.nih.gov/26359349" }, { "database": "PubMed", "id": "15661742", "url": "https://pubmed.ncbi.nlm.nih.gov/15661742" }, { "database": "PubMed", "id": "27354066", "url": "https://pubmed.ncbi.nlm.nih.gov/27354066" } ], "uniprot_canonical_ac": "Q00613-1" }, { "start_pos": 326, "end_pos": 326, "sequence_org": "S", "sequence_mut": "E", "comment": "Does not change interaction with XRCC5 and XRCC6.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "26359349", "url": "https://pubmed.ncbi.nlm.nih.gov/26359349" } ], "uniprot_canonical_ac": "Q00613-1" }, { "start_pos": 419, "end_pos": 419, "sequence_org": "S", "sequence_mut": "A", "comment": "Does not change interaction with XRCC5 and XRCC6. Decreased nuclear localization upon heat shock. Strongly decreases PLK1-induced phosphorylation. No change in PLK1-induced phosphorylation in mitosis.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "26359349", "url": "https://pubmed.ncbi.nlm.nih.gov/26359349" }, { "database": "PubMed", "id": "15661742", "url": "https://pubmed.ncbi.nlm.nih.gov/15661742" }, { "database": "PubMed", "id": "18794143", "url": "https://pubmed.ncbi.nlm.nih.gov/18794143" } ], "uniprot_canonical_ac": "Q00613-1" }, { "start_pos": 419, "end_pos": 419, "sequence_org": "S", "sequence_mut": "E", "comment": "Does not change interaction with XRCC5 and XRCC6.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "26359349", "url": "https://pubmed.ncbi.nlm.nih.gov/26359349" } ], "uniprot_canonical_ac": "Q00613-1" }, { "start_pos": 80, "end_pos": 80, "sequence_org": "K", "sequence_mut": "R", "comment": "Does not change interaction with XRCC5 and XRCC6. Loss of nuclear stress bodies localization. Decreased nuclear stress bodies localization. Loss of DNA-binding and transcriptional activities upon heat shock.", "evidence": [ { "database": "UniProtKB", "id": "Q00613", "url": "https://www.uniprot.org/uniprotkb/Q00613" }, { "database": "PubMed", "id": "24581496", "url": "https://pubmed.ncbi.nlm.nih.gov/24581496" }, { "database": "PubMed", "id": "26359349", "url": "https://pubmed.ncbi.nlm.nih.gov/26359349" }, { "database": "PubMed", "id": "19229036", "url": "https://pubmed.ncbi.nlm.nih.gov/19229036" } ], "uniprot_canonical_ac": "Q00613-1" } ], "record_id": "pubmed.26359349", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins.", "journal": "Nat. Commun.", "date": "2016", "authors": "Grundy GJ, Rulten SL, Arribas-Bosacoma R, Davidson K, Kozik Z, Oliver AW, Pearl LH, Caldecott KW", "reference": { "type": "PubMed", "id": "27063109", "url": "https://pubmed.ncbi.nlm.nih.gov/27063109" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P12956-1", "protein_name": "DNA repair protein Ku70", "gene_name": "XRCC6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BUH6-1", "protein_name": "Protein PAXX", "gene_name": "PAXX", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14191-1", "protein_name": "Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN", "gene_name": "WRN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BWK5-1", "protein_name": "Cell cycle regulator of non-homologous end joining", "gene_name": "CYREN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IW19-1", "protein_name": "Aprataxin and PNK-like factor", "gene_name": "APLF", "tax_name": "Human" }, { "uniprot_canonical_ac": "P13010-1", "protein_name": "DNA repair protein Ku80", "gene_name": "XRCC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H9Q4-1", "protein_name": "Non-homologous end-joining factor 1", "gene_name": "NHEJ1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P12956", "url": "https://www.uniprot.org/uniprotkb/P12956" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 18, "end_pos": 18, "sequence_org": "W", "sequence_mut": "G", "comment": "Abolished interaction with XRCC5 and XRCC6.", "evidence": [ { "database": "UniProtKB", "id": "Q14191", "url": "https://www.uniprot.org/uniprotkb/Q14191" }, { "database": "PubMed", "id": "27063109", "url": "https://pubmed.ncbi.nlm.nih.gov/27063109" } ], "uniprot_canonical_ac": "Q14191-1" }, { "start_pos": 84, "end_pos": 84, "sequence_org": "E", "sequence_mut": "A", "comment": "Abolishes exonuclease activity. Restores chromosome stability in depletion experiments.", "evidence": [ { "database": "UniProtKB", "id": "Q14191", "url": "https://www.uniprot.org/uniprotkb/Q14191" }, { "database": "PubMed", "id": "16622405", "url": "https://pubmed.ncbi.nlm.nih.gov/16622405" }, { "database": "PubMed", "id": "11863428", "url": "https://pubmed.ncbi.nlm.nih.gov/11863428" }, { "database": "PubMed", "id": "27063109", "url": "https://pubmed.ncbi.nlm.nih.gov/27063109" }, { "database": "PubMed", "id": "33199508", "url": "https://pubmed.ncbi.nlm.nih.gov/33199508" } ], "uniprot_canonical_ac": "Q14191-1" }, { "start_pos": 16, "end_pos": 16, "sequence_org": "W", "sequence_mut": "A", "comment": "Abolishes interaction with XRCC5/Ku80 and XRCC6/Ku70 and ability to inhibit classical non-homologous end joining (NHEJ). Does not affect interaction with SF3B1.", "evidence": [ { "database": "UniProtKB", "id": "Q9BWK5", "url": "https://www.uniprot.org/uniprotkb/Q9BWK5" }, { "database": "PubMed", "id": "28959974", "url": "https://pubmed.ncbi.nlm.nih.gov/28959974" }, { "database": "PubMed", "id": "27063109", "url": "https://pubmed.ncbi.nlm.nih.gov/27063109" }, { "database": "PubMed", "id": "37813856", "url": "https://pubmed.ncbi.nlm.nih.gov/37813856" } ], "uniprot_canonical_ac": "Q9BWK5-1" } ], "record_id": "pubmed.27063109", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 7 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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"Homo sapiens [9606]" } ], "phosphorylation": [ { "start_pos": 2, "end_pos": 2, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P12956", "url": "https://www.uniprot.org/uniprotkb/P12956" }, { "database": "PubMed", "id": "23186163", "url": "https://pubmed.ncbi.nlm.nih.gov/23186163" }, { "database": "iPTMnet", "id": "P12956", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P12956" }, { "database": "PubMed", "id": "27402161", "url": "https://pubmed.ncbi.nlm.nih.gov/27402161" } ], "site_lbl": "Ser2", "uniprot_canonical_ac": "P12956-1" } ], "record_id": "pubmed.27402161", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": 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"referenced_proteins": [ { "uniprot_canonical_ac": "P12956-1", "protein_name": "DNA repair protein Ku70", "gene_name": "XRCC6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BUH6-1", "protein_name": "Protein PAXX", "gene_name": "PAXX", "tax_name": "Human" }, { "uniprot_canonical_ac": "P13010-1", "protein_name": "DNA repair protein Ku80", "gene_name": "XRCC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8K0Y7-1", "protein_name": "Protein PAXX", "gene_name": "Paxx", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q3KNJ2-1", "protein_name": "Non-homologous end-joining factor 1", "gene_name": "Nhej1", "tax_name": "Mouse" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P12956", "url": "https://www.uniprot.org/uniprotkb/P12956" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 184, "end_pos": 184, "sequence_org": "S", "sequence_mut": 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Molecular cell research", "date": "2024-10", "authors": "Bayat Laila, Abbasi Sanna, Balasuriya Nileeka, Schild-Poulter Caroline", "reference": { "type": "PubMed", "id": "39151475", "url": "https://pubmed.ncbi.nlm.nih.gov/39151475" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P12956-1", "protein_name": "DNA repair protein Ku70", "gene_name": "XRCC6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13426-1", "protein_name": "DNA repair protein XRCC4", "gene_name": "XRCC4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49917-1", "protein_name": "DNA ligase 4", "gene_name": "LIG4", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P12956", "url": "https://www.uniprot.org/uniprotkb/P12956" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.39151475", "abstract": "", "glycosylation": [], "mutagenesis": 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calcium.", "journal": "The Journal of biological chemistry", "date": "1996", "authors": "Chung U, Igarashi T, Nishishita T, Iwanari H, Iwamatsu A, Suwa A, Mimori T, Hata K, Ebisu S, Ogata E, Fujita T, Okazaki T", "reference": { "type": "PubMed", "id": "8621488", "url": "https://pubmed.ncbi.nlm.nih.gov/8621488" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P12956-1", "protein_name": "DNA repair protein Ku70", "gene_name": "XRCC6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27695-1", "protein_name": "DNA repair nuclease/redox regulator APEX1", "gene_name": "APEX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P13010-1", "protein_name": "DNA repair protein Ku80", "gene_name": "XRCC5", "tax_name": 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor.", "journal": "Biochem. J.", "date": "2000", "authors": "Vitale G, Bernardi L, Napolitani G, Mock M, Montecucco C", "reference": { "type": "PubMed", "id": "11104681", "url": "https://pubmed.ncbi.nlm.nih.gov/11104681" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P36507-1", "protein_name": "Dual specificity mitogen-activated protein kinase kinase 2", "gene_name": "MAP2K2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P52564-1", "protein_name": "Dual specificity mitogen-activated protein kinase kinase 6", "gene_name": "MAP2K6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09958-1", "protein_name": "Furin", "gene_name": "FURIN", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14733-1", "protein_name": "Dual specificity mitogen-activated protein kinase kinase 7", "gene_name": "MAP2K7", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0DP23-1", "protein_name": "Calmodulin-1", "gene_name": "CALM1; CALM2; CALM3", "tax_name": "Human" }, { "uniprot_canonical_ac": 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"PDCD6IP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P45985-1", "protein_name": "Dual specificity mitogen-activated protein kinase kinase 4", "gene_name": "MAP2K4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q02750-1", "protein_name": "Dual specificity mitogen-activated protein kinase kinase 1", "gene_name": "MAP2K1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P36507", "url": "https://www.uniprot.org/uniprotkb/P36507" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.25974265", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 7 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", 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"Q02750-1" }, { "start_pos": 222, "end_pos": 222, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by BRAF and RAF1", "evidence": [ { "database": "UniProtKB", "id": "Q02750", "url": "https://www.uniprot.org/uniprotkb/Q02750" }, { "database": "iPTMnet", "id": "Q02750", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q02750" }, { "database": "PubMed", "id": "15466214", "url": "https://pubmed.ncbi.nlm.nih.gov/15466214" }, { "database": "PRO", "id": "Q02750", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=Q02750" }, { "database": "PubMed", "id": "8131746", "url": "https://pubmed.ncbi.nlm.nih.gov/8131746" }, { "database": "PubMed", "id": "10037701", "url": "https://pubmed.ncbi.nlm.nih.gov/10037701" }, { "database": "PubMed", "id": "14993270", "url": "https://pubmed.ncbi.nlm.nih.gov/14993270" }, { "database": "PubMed", "id": "21793567", "url": "https://pubmed.ncbi.nlm.nih.gov/21793567" }, { "database": "PubMed", 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No effect on BRAF-KSR1 dimerization; when associated with A-222.", "evidence": [ { "database": "UniProtKB", "id": "Q02750", "url": "https://www.uniprot.org/uniprotkb/Q02750" }, { "database": "PubMed", "id": "29433126", "url": "https://pubmed.ncbi.nlm.nih.gov/29433126" }, { "database": "PubMed", "id": "8131746", "url": "https://pubmed.ncbi.nlm.nih.gov/8131746" } ], "uniprot_canonical_ac": "Q02750-1" }, { "start_pos": 218, "end_pos": 218, "sequence_org": "S", "sequence_mut": "D", "comment": "No effect on BRAF-KSR1 dimerization; when associated with D-222.", "evidence": [ { "database": "UniProtKB", "id": "Q02750", "url": "https://www.uniprot.org/uniprotkb/Q02750" }, { "database": "PubMed", "id": "29433126", "url": "https://pubmed.ncbi.nlm.nih.gov/29433126" } ], "uniprot_canonical_ac": "Q02750-1" }, { "start_pos": 219, "end_pos": 219, "sequence_org": "M", "sequence_mut": "V", "comment": "Increases interaction with KSR1 and BRAF.", "evidence": [ { "database": "UniProtKB", "id": "Q02750", "url": "https://www.uniprot.org/uniprotkb/Q02750" }, { "database": "PubMed", "id": "29433126", "url": "https://pubmed.ncbi.nlm.nih.gov/29433126" } ], "uniprot_canonical_ac": "Q02750-1" }, { "start_pos": 219, "end_pos": 219, "sequence_org": "M", "sequence_mut": "W", "comment": "Increases interaction with KSR1 and BRAF; when associated with L-220.", "evidence": [ { "database": "UniProtKB", "id": "Q02750", "url": "https://www.uniprot.org/uniprotkb/Q02750" }, { "database": "PubMed", "id": "29433126", "url": "https://pubmed.ncbi.nlm.nih.gov/29433126" } ], "uniprot_canonical_ac": "Q02750-1" }, { "start_pos": 220, "end_pos": 220, "sequence_org": "A", "sequence_mut": "L", "comment": "Increases interaction with KSR1 and BRAF; when associated with w-219.", "evidence": [ { "database": "UniProtKB", "id": "Q02750", "url": "https://www.uniprot.org/uniprotkb/Q02750" }, { "database": "PubMed", "id": "29433126", "url": "https://pubmed.ncbi.nlm.nih.gov/29433126" } ], "uniprot_canonical_ac": "Q02750-1" }, { "start_pos": 221, "end_pos": 221, "sequence_org": "N", "sequence_mut": "Y", "comment": "Increases interaction with KSR1 and BRAF.", "evidence": [ { "database": "UniProtKB", "id": "Q02750", "url": "https://www.uniprot.org/uniprotkb/Q02750" }, { "database": "PubMed", "id": "29433126", "url": "https://pubmed.ncbi.nlm.nih.gov/29433126" } ], "uniprot_canonical_ac": "Q02750-1" }, { "start_pos": 222, "end_pos": 222, "sequence_org": "S", "sequence_mut": "A", "comment": "Loss of catalytic activity. No effect on BRAF-KSR1 dimerization; when associated with A-218.", "evidence": [ { "database": "UniProtKB", "id": "Q02750", "url": "https://www.uniprot.org/uniprotkb/Q02750" }, { "database": "PubMed", "id": "29433126", "url": "https://pubmed.ncbi.nlm.nih.gov/29433126" }, { "database": "PubMed", "id": "8131746", "url": "https://pubmed.ncbi.nlm.nih.gov/8131746" } ], "uniprot_canonical_ac": "Q02750-1" }, { "start_pos": 222, "end_pos": 222, "sequence_org": "S", "sequence_mut": "D", "comment": "No effect on BRAF-KSR1 dimerization; when associated with D-218.", "evidence": [ { "database": "UniProtKB", "id": "Q02750", "url": "https://www.uniprot.org/uniprotkb/Q02750" }, { "database": "PubMed", "id": "29433126", "url": "https://pubmed.ncbi.nlm.nih.gov/29433126" } ], "uniprot_canonical_ac": "Q02750-1" }, { "start_pos": 311, "end_pos": 311, "sequence_org": "F", "sequence_mut": "S", "comment": "Loss of interaction with BRAF and KSR1. Loss of BRAF-KSR1 dimerization.", "evidence": [ { "database": "UniProtKB", "id": "Q02750", "url": "https://www.uniprot.org/uniprotkb/Q02750" }, { "database": "PubMed", "id": "29433126", "url": "https://pubmed.ncbi.nlm.nih.gov/29433126" } ], "uniprot_canonical_ac": "Q02750-1" }, { "start_pos": 97, "end_pos": 97, "sequence_org": "K", "sequence_mut": "R", "comment": "Loss of catalytic activity. No effect on BRAF-KSR1 or BRAF-KSR2 dimerization.", "evidence": [ { "database": "UniProtKB", "id": "Q02750", "url": "https://www.uniprot.org/uniprotkb/Q02750" }, { "database": "PubMed", "id": "29433126", "url": "https://pubmed.ncbi.nlm.nih.gov/29433126" }, { "database": "PubMed", "id": "8131746", "url": "https://pubmed.ncbi.nlm.nih.gov/8131746" } ], "uniprot_canonical_ac": "Q02750-1" }, { "start_pos": 47, "end_pos": 47, "sequence_org": "L", "sequence_mut": "D", "comment": "Reduces interaction with BRAF and MAP2K1 and thus phosphorylation of MAP2K1.", "evidence": [ { "database": "UniProtKB", "id": "Q8IVT5", "url": "https://www.uniprot.org/uniprotkb/Q8IVT5" }, { "database": "PubMed", "id": "29433126", "url": "https://pubmed.ncbi.nlm.nih.gov/29433126" } ], "uniprot_canonical_ac": "Q8IVT5-1" }, { "start_pos": 602, "end_pos": 604, "sequence_org": "YLQ", "sequence_mut": "DDE", "comment": "No effect on MAP2K1- or MAP2K2-mediated-BRAF-KSR1 dimerization and BRAF activation.", "evidence": [ { "database": "UniProtKB", "id": "Q8IVT5", "url": "https://www.uniprot.org/uniprotkb/Q8IVT5" }, { "database": "PubMed", "id": "29433126", "url": "https://pubmed.ncbi.nlm.nih.gov/29433126" } ], "uniprot_canonical_ac": "Q8IVT5-1" }, { "start_pos": 62, "end_pos": 62, "sequence_org": "C", "sequence_mut": "D", "comment": "Reduces interaction with BRAF and MAP2K1 and thus phosphorylation of MAP2K1.", "evidence": [ { "database": "UniProtKB", "id": "Q8IVT5", "url": "https://www.uniprot.org/uniprotkb/Q8IVT5" }, { "database": "PubMed", "id": "29433126", "url": "https://pubmed.ncbi.nlm.nih.gov/29433126" } ], "uniprot_canonical_ac": "Q8IVT5-1" }, { "start_pos": 637, "end_pos": 637, "sequence_org": "A", "sequence_mut": "F", "comment": "No effect on MAP2K1 or MAP2K2 mediated-BRAF-KSR1 dimerization and BRAF activation.", "evidence": [ { "database": "UniProtKB", "id": "Q8IVT5", "url": "https://www.uniprot.org/uniprotkb/Q8IVT5" }, { "database": "PubMed", "id": "29433126", "url": "https://pubmed.ncbi.nlm.nih.gov/29433126" } ], "uniprot_canonical_ac": "Q8IVT5-1" }, { "start_pos": 639, "end_pos": 639, "sequence_org": "R", "sequence_mut": "M", "comment": "No effect on MAP2K1 mediated-BRAF-KSR1 dimerization and BRAF activation.", "evidence": [ { "database": "UniProtKB", "id": "Q8IVT5", "url": "https://www.uniprot.org/uniprotkb/Q8IVT5" }, { "database": "PubMed", "id": "29433126", "url": "https://pubmed.ncbi.nlm.nih.gov/29433126" } ], "uniprot_canonical_ac": "Q8IVT5-1" }, { "start_pos": 665, "end_pos": 665, "sequence_org": "R", "sequence_mut": "H", "comment": "Loss of MAP2K1 mediated-BRAF-KSR1 dimerization.", "evidence": [ { "database": "UniProtKB", "id": "Q8IVT5", "url": "https://www.uniprot.org/uniprotkb/Q8IVT5" }, { "database": "PubMed", "id": "29433126", "url": "https://pubmed.ncbi.nlm.nih.gov/29433126" } ], "uniprot_canonical_ac": "Q8IVT5-1" }, { "start_pos": 72, "end_pos": 72, "sequence_org": "E", "sequence_mut": "K", "comment": "Loss of interaction with BRAF and MAP2K1 and severe decrease in MAP2K1 phosphorylation levels.", "evidence": [ { "database": "UniProtKB", "id": "Q8IVT5", "url": "https://www.uniprot.org/uniprotkb/Q8IVT5" }, { "database": "PubMed", "id": "29433126", "url": "https://pubmed.ncbi.nlm.nih.gov/29433126" } ], "uniprot_canonical_ac": "Q8IVT5-1" }, { "start_pos": 831, "end_pos": 831, "sequence_org": "W", "sequence_mut": "R", "comment": "Loss of the interaction with MAP2K1 resulting in loss of BRAF-KSR1 dimerization and BRAF activation. 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Cell-derived Extracellular Vesicles Partially Through MEK2-dependent Macropinocytosis.", "journal": "Cancer research communications", "date": "2024-01-22", "authors": "Wan Yuhao, Zhao Yue, Cao Minghui, Wang Jingyi, Tran Sheila V, Song Zhixuan, Hsueh Brent W, Wang Shizhen Emily", "reference": { "type": "PubMed", "id": "38259097", "url": "https://pubmed.ncbi.nlm.nih.gov/38259097" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P36507-1", "protein_name": "Dual specificity mitogen-activated protein kinase kinase 2", "gene_name": "MAP2K2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P36507", "url": "https://www.uniprot.org/uniprotkb/P36507" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.38259097", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], 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cultured macrophages.", "journal": "Biochemical and biophysical research communications", "date": "1998", "authors": "Vitale G, Pellizzari R, Recchi C, Napolitani G, Mock M, Montecucco C", "reference": { "type": "PubMed", "id": "9703991", "url": "https://pubmed.ncbi.nlm.nih.gov/9703991" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P36507-1", "protein_name": "Dual specificity mitogen-activated protein kinase kinase 2", "gene_name": "MAP2K2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09958-1", "protein_name": "Furin", "gene_name": "FURIN", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14733-1", "protein_name": "Dual specificity mitogen-activated protein kinase kinase 7", "gene_name": "MAP2K7", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0DP23-1", "protein_name": "Calmodulin-1", "gene_name": "CALM1; CALM2; CALM3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WUM4-1", "protein_name": "Programmed cell death 6-interacting 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Genet.", "date": "1995", "authors": "Quan F, Janas J, Popovich B W", "reference": { "type": "PubMed", "id": "8634720", "url": "https://pubmed.ncbi.nlm.nih.gov/8634720" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P54253-1", "protein_name": "Ataxin-1", "gene_name": "ATXN1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P54253", "url": "https://www.uniprot.org/uniprotkb/P54253" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.8634720", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Identification of a self-association region within the SCA1 gene product, ataxin-1.", "journal": "Hum. 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"TP53", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P99999", "url": "https://www.uniprot.org/uniprotkb/P99999" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.19859801", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 27 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { 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"count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes.", "journal": "Nature communications", "date": "2015", "authors": "Vigano E, Diamond CE, Spreafico R, Balachander A, Sobota RM, Mortellaro A", "reference": { "type": "PubMed", "id": "26508369", "url": "https://pubmed.ncbi.nlm.nih.gov/26508369" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P99999-1", "protein_name": "Cytochrome c", "gene_name": "CYCS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P29466-1", "protein_name": "Caspase-1", "gene_name": "CASP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q07812-1", "protein_name": "Apoptosis regulator BAX", "gene_name": "BAX", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09429-1", "protein_name": "High mobility group protein B1", "gene_name": "HMGB1", "tax_name": "Human" }, { 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"Pore-forming activity and structural autoinhibition of the gasdermin family.", "journal": "Nature", "date": "2016", "authors": "Ding J, Wang K, Liu W, She Y, Sun Q, Shi J, Sun H, Wang DC, Shao F", "reference": { "type": "PubMed", "id": "27281216", "url": "https://pubmed.ncbi.nlm.nih.gov/27281216" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P99999-1", "protein_name": "Cytochrome c", "gene_name": "CYCS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P29466-1", "protein_name": "Caspase-1", "gene_name": "CASP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q07812-1", "protein_name": "Apoptosis regulator BAX", "gene_name": "BAX", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09429-1", "protein_name": "High mobility group protein B1", "gene_name": "HMGB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96FZ7-1", "protein_name": "Charged multivesicular body protein 6", "gene_name": "CHMP6", "tax_name": "Human" }, { 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"field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 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factor 1", "gene_name": "IRF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P32455-1", "protein_name": "Guanylate-binding protein 1", "gene_name": "GBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96PP9-1", "protein_name": "Guanylate-binding protein 4", "gene_name": "GBP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14116-1", "protein_name": "Interleukin-18", "gene_name": "IL18", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42574-1", "protein_name": "Caspase-3", "gene_name": "CASP3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H0R5-1", "protein_name": "Guanylate-binding protein 3", "gene_name": "GBP3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H444-1", "protein_name": "Charged multivesicular body protein 4b", "gene_name": "CHMP4B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P32456-1", "protein_name": "Guanylate-binding protein 2", "gene_name": "GBP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P10144-1", "protein_name": "Granzyme B", "gene_name": "GZMB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04637-1", "protein_name": "Cellular tumor antigen p53", "gene_name": "TP53", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P99999", "url": "https://www.uniprot.org/uniprotkb/P99999" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.29177860", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 35 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": 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"BAX", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09429-1", "protein_name": "High mobility group protein B1", "gene_name": "HMGB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96FZ7-1", "protein_name": "Charged multivesicular body protein 6", "gene_name": "CHMP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08246-1", "protein_name": "Neutrophil elastase", "gene_name": "ELANE", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WUX9-1", "protein_name": "Charged multivesicular body protein 7", "gene_name": "CHMP7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BY43-1", "protein_name": "Charged multivesicular body protein 4a", "gene_name": "CHMP4A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y3E7-1", "protein_name": "Charged multivesicular body protein 3", "gene_name": "CHMP3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43633-1", "protein_name": "Charged multivesicular body protein 2a", "gene_name": "CHMP2A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UQN3-1", "protein_name": "Charged multivesicular body protein 2b", "gene_name": "CHMP2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01584-1", "protein_name": "Interleukin-1 beta", "gene_name": "IL1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14316-1", "protein_name": "Interferon regulatory factor 2", "gene_name": "IRF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H3D4-1", "protein_name": "Tumor protein 63", "gene_name": "TP63", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16611-1", "protein_name": "Bcl-2 homologous antagonist/killer", "gene_name": "BAK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01583-1", "protein_name": "Interleukin-1 alpha", "gene_name": "IL1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49662-1", "protein_name": "Caspase-4", "gene_name": "CASP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96CF2-1", "protein_name": "Charged multivesicular body protein 4c", "gene_name": "CHMP4C", "tax_name": "Human" }, { "uniprot_canonical_ac": "P51878-1", "protein_name": "Caspase-5", "gene_name": "CASP5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P57764-1", "protein_name": "Gasdermin-D", "gene_name": "GSDMD", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60443-1", "protein_name": "Gasdermin-E", "gene_name": "GSDME", "tax_name": "Human" }, { "uniprot_canonical_ac": "P10914-1", "protein_name": "Interferon regulatory factor 1", "gene_name": "IRF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14116-1", "protein_name": "Interleukin-18", "gene_name": "IL18", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42574-1", "protein_name": "Caspase-3", "gene_name": "CASP3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H444-1", "protein_name": "Charged multivesicular body protein 4b", "gene_name": "CHMP4B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P10144-1", "protein_name": "Granzyme B", "gene_name": "GZMB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04637-1", "protein_name": "Cellular tumor antigen p53", "gene_name": "TP53", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P99999", "url": "https://www.uniprot.org/uniprotkb/P99999" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.29539421", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 27 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, 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"gene_name": "BAX", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09429-1", "protein_name": "High mobility group protein B1", "gene_name": "HMGB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96FZ7-1", "protein_name": "Charged multivesicular body protein 6", "gene_name": "CHMP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08246-1", "protein_name": "Neutrophil elastase", "gene_name": "ELANE", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WUX9-1", "protein_name": "Charged multivesicular body protein 7", "gene_name": "CHMP7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BY43-1", "protein_name": "Charged multivesicular body protein 4a", "gene_name": "CHMP4A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y3E7-1", "protein_name": "Charged multivesicular body protein 3", "gene_name": "CHMP3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43633-1", "protein_name": "Charged multivesicular body protein 2a", "gene_name": "CHMP2A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UQN3-1", "protein_name": "Charged multivesicular body protein 2b", "gene_name": "CHMP2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01584-1", "protein_name": "Interleukin-1 beta", "gene_name": "IL1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14316-1", "protein_name": "Interferon regulatory factor 2", "gene_name": "IRF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H3D4-1", "protein_name": "Tumor protein 63", "gene_name": "TP63", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16611-1", "protein_name": "Bcl-2 homologous antagonist/killer", "gene_name": "BAK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01583-1", "protein_name": "Interleukin-1 alpha", "gene_name": "IL1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49662-1", "protein_name": "Caspase-4", "gene_name": "CASP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96CF2-1", "protein_name": "Charged multivesicular body protein 4c", "gene_name": 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"uniprot_canonical_ac": "P04637-1", "protein_name": "Cellular tumor antigen p53", "gene_name": "TP53", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P99999", "url": "https://www.uniprot.org/uniprotkb/P99999" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.29891674", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 27 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, 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[] } ] }, { "title": "Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death.", "journal": "Journal of molecular biology", "date": "2018", "authors": "Feng S, Fox D, Man SM", "reference": { "type": "PubMed", "id": "29990470", "url": "https://pubmed.ncbi.nlm.nih.gov/29990470" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P99999-1", "protein_name": "Cytochrome c", "gene_name": "CYCS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P29466-1", "protein_name": "Caspase-1", "gene_name": "CASP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q07812-1", "protein_name": "Apoptosis regulator BAX", "gene_name": "BAX", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09429-1", "protein_name": "High mobility group protein B1", "gene_name": "HMGB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96FZ7-1", "protein_name": "Charged multivesicular body protein 6", "gene_name": "CHMP6", "tax_name": "Human" }, { 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"glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.29990470", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 27 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": 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"protein_name": "Interleukin-18", "gene_name": "IL18", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42574-1", "protein_name": "Caspase-3", "gene_name": "CASP3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H444-1", "protein_name": "Charged multivesicular body protein 4b", "gene_name": "CHMP4B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P10144-1", "protein_name": "Granzyme B", "gene_name": "GZMB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04637-1", "protein_name": "Cellular tumor antigen p53", "gene_name": "TP53", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P99999", "url": "https://www.uniprot.org/uniprotkb/P99999" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.32367036", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 27 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": 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"field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Effects of naturally occurring S47F/A mutations on the structure and function of human cytochrome c.", "journal": "Journal of inorganic biochemistry", "date": "2023-09", "authors": "Li Yan-Yan, Long Shuang-Shuang, Yu Lu, Liu Ao-Kun, Gao Shu-Qin, Tan Xiangshi, Lin Ying-Wu", "reference": { "type": "PubMed", "id": "37356378", "url": "https://pubmed.ncbi.nlm.nih.gov/37356378" 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"taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P99999", "url": "https://www.uniprot.org/uniprotkb/P99999" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.38472487", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The Y49H cytochrome c variant enhances megakaryocytic maturation of K-562 cells.", "journal": "Biochimica et biophysica acta. Molecular basis of disease", "date": "2024-06", "authors": "Shafaei Pishabad Zahra, Ledgerwood Elizabeth C", "reference": { "type": "PubMed", "id": "38531481", "url": "https://pubmed.ncbi.nlm.nih.gov/38531481" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P99999-1", "protein_name": "Cytochrome c", "gene_name": "CYCS", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P99999", "url": "https://www.uniprot.org/uniprotkb/P99999" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.38531481", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": 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"id": "9515723", "url": "https://pubmed.ncbi.nlm.nih.gov/9515723" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P99999-1", "protein_name": "Cytochrome c", "gene_name": "CYCS", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P99999", "url": "https://www.uniprot.org/uniprotkb/P99999" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.9515723", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", 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Invest. Dermatol.", "date": "2004", "authors": "Rogers Michael A, Langbein Lutz, Winter Hermelita, Beckmann Iris, Praetzel Silke, Schweizer J\u00fcrgen", "reference": { "type": "PubMed", "id": "14962103", "url": "https://pubmed.ncbi.nlm.nih.gov/14962103" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P59991-1", "protein_name": "Keratin-associated protein 12-2", "gene_name": "KRTAP12-2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P60331-1", "protein_name": "Keratin-associated protein 10-1", "gene_name": "KRTAP10-1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P60328-1", "protein_name": "Keratin-associated protein 12-3", "gene_name": "KRTAP12-3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P60329-1", "protein_name": "Keratin-associated protein 12-4", "gene_name": "KRTAP12-4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P60413-1", "protein_name": "Keratin-associated protein 10-12", "gene_name": "KRTAP10-12", "tax_name": "Human" }, { "uniprot_canonical_ac": "P60014-1", "protein_name": "Keratin-associated protein 10-10", "gene_name": "KRTAP10-10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P60368-1", "protein_name": "Keratin-associated protein 10-2", "gene_name": "KRTAP10-2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P60369-1", "protein_name": "Keratin-associated protein 10-3", "gene_name": "KRTAP10-3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P59990-1", "protein_name": "Keratin-associated protein 12-1", "gene_name": "KRTAP12-1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P60412-1", "protein_name": "Keratin-associated protein 10-11", "gene_name": "KRTAP10-11", "tax_name": "Human" }, { "uniprot_canonical_ac": "P60371-1", "protein_name": "Keratin-associated protein 10-6", "gene_name": "KRTAP10-6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P60370-1", "protein_name": "Keratin-associated protein 10-5", "gene_name": "KRTAP10-5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P60409-1", "protein_name": "Keratin-associated protein 10-7", "gene_name": "KRTAP10-7", "tax_name": "Human" }, { "uniprot_canonical_ac": "P60410-1", "protein_name": "Keratin-associated protein 10-8", "gene_name": "KRTAP10-8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P60411-1", "protein_name": "Keratin-associated protein 10-9", "gene_name": "KRTAP10-9", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P59991", "url": "https://www.uniprot.org/uniprotkb/P59991" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.14962103", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 15 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": 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