[
    {
        "title": "Mutant epidermal growth factor receptor displays increased signaling through the phosphatidylinositol-3 kinase/AKT pathway and promotes radioresistance in cells of astrocytic origin.",
        "journal": "Oncogene",
        "date": "2004",
        "authors": "Li B, Yuan M, Kim IA, Chang CM, Bernhard EJ, Shu HK",
        "reference": {
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    {
        "title": "The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells.",
        "journal": "The Journal of biological chemistry",
        "date": "2004",
        "authors": "Maggiolini M, Vivacqua A, Fasanella G, Recchia AG, Sisci D, Pezzi V, Montanaro D, Musti AM, Picard D, Ando S",
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                "gene_name": "AKT3",
                "tax_name": "Human"
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    {
        "title": "Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations.",
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                "uniprot_canonical_ac": "P60953-2",
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                "protein_name": "RalBP1-associated Eps domain-containing protein 2",
                "gene_name": "REPS2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8NBV8-4",
                "protein_name": "Synaptotagmin-8",
                "gene_name": "SYT8",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8N9I0-1",
                "protein_name": "Synaptotagmin-2",
                "gene_name": "SYT2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q86SS6-1",
                "protein_name": "Synaptotagmin-9",
                "gene_name": "SYT9",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P51809-1",
                "protein_name": "Vesicle-associated membrane protein 7",
                "gene_name": "VAMP7",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P52594-1",
                "protein_name": "Arf-GAP domain and FG repeat-containing protein 1",
                "gene_name": "AGFG1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9BT88-1",
                "protein_name": "Synaptotagmin-11",
                "gene_name": "SYT11",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O60641-1",
                "protein_name": "Clathrin coat assembly protein AP180",
                "gene_name": "SNAP91",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O15145-1",
                "protein_name": "Actin-related protein 2/3 complex subunit 3",
                "gene_name": "ARPC3",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9Y5X1-1",
                "protein_name": "Sorting nexin-9",
                "gene_name": "SNX9",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q14247-1",
                "protein_name": "Src substrate cortactin",
                "gene_name": "CTTN",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P15514-1",
                "protein_name": "Amphiregulin",
                "gene_name": "AREG",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O95782-1",
                "protein_name": "AP-2 complex subunit alpha-1",
                "gene_name": "AP2A1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P04114-1",
                "protein_name": "Apolipoprotein B-100",
                "gene_name": "APOB",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P59998-1",
                "protein_name": "Actin-related protein 2/3 complex subunit 4",
                "gene_name": "ARPC4",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O15144-1",
                "protein_name": "Actin-related protein 2/3 complex subunit 2",
                "gene_name": "ARPC2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8N6T3-1",
                "protein_name": "ADP-ribosylation factor GTPase-activating protein 1",
                "gene_name": "ARFGAP1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P61158-1",
                "protein_name": "Actin-related protein 3",
                "gene_name": "ACTR3",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O15511-1",
                "protein_name": "Actin-related protein 2/3 complex subunit 5",
                "gene_name": "ARPC5",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P61160-1",
                "protein_name": "Actin-related protein 2",
                "gene_name": "ACTR2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O00401-1",
                "protein_name": "Actin nucleation-promoting factor WASL",
                "gene_name": "WASL",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P25103-1",
                "protein_name": "Substance-P receptor",
                "gene_name": "TACR1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q96D71-1",
                "protein_name": "RalBP1-associated Eps domain-containing protein 1",
                "gene_name": "REPS1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P53675-1",
                "protein_name": "Clathrin heavy chain 2",
                "gene_name": "CLTCL1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q5T0N5-1",
                "protein_name": "Formin-binding protein 1-like",
                "gene_name": "FNBP1L",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q80TY0-1",
                "protein_name": "Formin-binding protein 1",
                "gene_name": "Fnbp1",
                "tax_name": "Mouse"
            },
            {
                "uniprot_canonical_ac": "Q92783-1",
                "protein_name": "Signal transducing adapter molecule 1",
                "gene_name": "STAM",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P16871-1",
                "protein_name": "Interleukin-7 receptor subunit alpha",
                "gene_name": "IL7R",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P63027-1",
                "protein_name": "Vesicle-associated membrane protein 2",
                "gene_name": "VAMP2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q5VV43-1",
                "protein_name": "Dyslexia-associated protein KIAA0319",
                "gene_name": "KIAA0319",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O75146-1",
                "protein_name": "Huntingtin-interacting protein 1-related protein",
                "gene_name": "HIP1R",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O00291-1",
                "protein_name": "Huntingtin-interacting protein 1",
                "gene_name": "HIP1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P01185-1",
                "protein_name": "Vasopressin-neurophysin 2-copeptin",
                "gene_name": "AVP",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O00443-1",
                "protein_name": "Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha",
                "gene_name": "PIK3C2A",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9Y6Q2-1",
                "protein_name": "Stonin-1",
                "gene_name": "STON1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9BV40-1",
                "protein_name": "Vesicle-associated membrane protein 8",
                "gene_name": "VAMP8",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q96RU3-1",
                "protein_name": "Formin-binding protein 1",
                "gene_name": "FNBP1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P01135-1",
                "protein_name": "Protransforming growth factor alpha",
                "gene_name": "TGFA",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P61020-1",
                "protein_name": "Ras-related protein Rab-5B",
                "gene_name": "RAB5B",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q99963-1",
                "protein_name": "Endophilin-A3",
                "gene_name": "SH3GL3",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O14976-1",
                "protein_name": "Cyclin-G-associated kinase",
                "gene_name": "GAK",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q15836-1",
                "protein_name": "Vesicle-associated membrane protein 3",
                "gene_name": "VAMP3",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P30518-1",
                "protein_name": "Vasopressin V2 receptor",
                "gene_name": "AVPR2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P04234-1",
                "protein_name": "T-cell surface glycoprotein CD3 delta chain",
                "gene_name": "CD3D",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P09693-1",
                "protein_name": "T-cell surface glycoprotein CD3 gamma chain",
                "gene_name": "CD3G",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9UBC2-1",
                "protein_name": "Epidermal growth factor receptor substrate 15-like 1",
                "gene_name": "EPS15L1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P98082-1",
                "protein_name": "Disabled homolog 2",
                "gene_name": "DAB2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O43493-2",
                "protein_name": "Trans-Golgi network integral membrane protein 2",
                "gene_name": "TGOLN2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O75379-1",
                "protein_name": "Vesicle-associated membrane protein 4",
                "gene_name": "VAMP4",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q13492-1",
                "protein_name": "Phosphatidylinositol-binding clathrin assembly protein",
                "gene_name": "PICALM",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9BQI5-1",
                "protein_name": "SH3-containing GRB2-like protein 3-interacting protein 1",
                "gene_name": "SGIP1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q16572-1",
                "protein_name": "Vesicular acetylcholine transporter",
                "gene_name": "SLC18A3",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9NZM3-1",
                "protein_name": "Intersectin-2",
                "gene_name": "ITSN2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P98164-1",
                "protein_name": "Low-density lipoprotein receptor-related protein 2",
                "gene_name": "LRP2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9UNF0-1",
                "protein_name": "Protein kinase C and casein kinase substrate in neurons protein 2",
                "gene_name": "PACSIN2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O14526-1",
                "protein_name": "F-BAR domain only protein 1",
                "gene_name": "FCHO1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q99961-1",
                "protein_name": "Endophilin-A2",
                "gene_name": "SH3GL1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P30556-1",
                "protein_name": "Type-1 angiotensin II receptor",
                "gene_name": "AGTR1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q00610-1",
                "protein_name": "Clathrin heavy chain 1",
                "gene_name": "CLTC",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P07550-1",
                "protein_name": "Beta-2 adrenergic receptor",
                "gene_name": "ADRB2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P11142-1",
                "protein_name": "Heat shock cognate 71 kDa protein",
                "gene_name": "HSPA8",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q96B97-1",
                "protein_name": "SH3 domain-containing kinase-binding protein 1",
                "gene_name": "SH3KBP1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P63010-1",
                "protein_name": "AP-2 complex subunit beta",
                "gene_name": "AP2B1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P32121-1",
                "protein_name": "Beta-arrestin-2",
                "gene_name": "ARRB2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P63261-1",
                "protein_name": "Actin, cytoplasmic 2",
                "gene_name": "ACTG1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P50570-1",
                "protein_name": "Dynamin-2",
                "gene_name": "DNM2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P49407-1",
                "protein_name": "Beta-arrestin-1",
                "gene_name": "ARRB1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O14641-1",
                "protein_name": "Segment polarity protein dishevelled homolog DVL-2",
                "gene_name": "DVL2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q92747-1",
                "protein_name": "Actin-related protein 2/3 complex subunit 1A",
                "gene_name": "ARPC1A",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P62330-1",
                "protein_name": "ADP-ribosylation factor 6",
                "gene_name": "ARF6",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q5SW96-1",
                "protein_name": "Low density lipoprotein receptor adapter protein 1",
                "gene_name": "LDLRAP1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P01130-1",
                "protein_name": "Low-density lipoprotein receptor",
                "gene_name": "LDLR",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q96CW1-1",
                "protein_name": "AP-2 complex subunit mu",
                "gene_name": "AP2M1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P20339-1",
                "protein_name": "Ras-related protein Rab-5A",
                "gene_name": "RAB5A",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P49418-1",
                "protein_name": "Amphiphysin",
                "gene_name": "AMPH",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P02786-1",
                "protein_name": "Transferrin receptor protein 1",
                "gene_name": "TFRC",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q01968-1",
                "protein_name": "Inositol polyphosphate 5-phosphatase OCRL",
                "gene_name": "OCRL",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9ULV1-1",
                "protein_name": "Frizzled-4",
                "gene_name": "FZD4",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q14C86-1",
                "protein_name": "GTPase-activating protein and VPS9 domain-containing protein 1",
                "gene_name": "GAPVD1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O15056-1",
                "protein_name": "Polyphosphatidylinositol phosphatase SYNJ2",
                "gene_name": "SYNJ2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P02787-1",
                "protein_name": "Serotransferrin",
                "gene_name": "TF",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P41221-1",
                "protein_name": "Protein Wnt-5a",
                "gene_name": "WNT5A",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P62979-1",
                "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein",
                "gene_name": "RPS27A",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O00499-1",
                "protein_name": "Myc box-dependent-interacting protein 1",
                "gene_name": "BIN1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P13569-1",
                "protein_name": "Cystic fibrosis transmembrane conductance regulator",
                "gene_name": "CFTR",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P21579-1",
                "protein_name": "Synaptotagmin-1",
                "gene_name": "SYT1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P09496-1",
                "protein_name": "Clathrin light chain A",
                "gene_name": "CLTA",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q14108-1",
                "protein_name": "Lysosome membrane protein 2",
                "gene_name": "SCARB2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O60331-1",
                "protein_name": "Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma",
                "gene_name": "PIP5K1C",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9BY11-1",
                "protein_name": "Protein kinase C and casein kinase substrate in neurons protein 1",
                "gene_name": "PACSIN1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O43426-1",
                "protein_name": "Polyphosphatidylinositol phosphatase SYNJ1",
                "gene_name": "SYNJ1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P35070-1",
                "protein_name": "Probetacellulin",
                "gene_name": "BTC",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O75061-1",
                "protein_name": "Auxilin",
                "gene_name": "DNAJC6",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q15811-1",
                "protein_name": "Intersectin-1",
                "gene_name": "ITSN1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P01730-1",
                "protein_name": "T-cell surface glycoprotein CD4",
                "gene_name": "CD4",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P0CG47-1",
                "protein_name": "Polyubiquitin-B",
                "gene_name": "UBB",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P09497-1",
                "protein_name": "Clathrin light chain B",
                "gene_name": "CLTB",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P62987-1",
                "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein",
                "gene_name": "UBA52",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q05193-1",
                "protein_name": "Dynamin-1",
                "gene_name": "DNM1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9Y6I3-2",
                "protein_name": "Epsin-1",
                "gene_name": "EPN1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P51148-1",
                "protein_name": "Ras-related protein Rab-5C",
                "gene_name": "RAB5C",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q0JRZ9-1",
                "protein_name": "F-BAR domain only protein 2",
                "gene_name": "FCHO2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9UQ16-1",
                "protein_name": "Dynamin-3",
                "gene_name": "DNM3",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P42566-1",
                "protein_name": "Epidermal growth factor receptor substrate 15",
                "gene_name": "EPS15",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O95208-1",
                "protein_name": "Epsin-2",
                "gene_name": "EPN2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8WXE9-1",
                "protein_name": "Stonin-2",
                "gene_name": "STON2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P11717-1",
                "protein_name": "Cation-independent mannose-6-phosphate receptor",
                "gene_name": "IGF2R",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9NY64-1",
                "protein_name": "Solute carrier family 2, facilitated glucose transporter member 8",
                "gene_name": "SLC2A8",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q99075-1",
                "protein_name": "Proheparin-binding EGF-like growth factor",
                "gene_name": "HBEGF",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P20645-1",
                "protein_name": "Cation-dependent mannose-6-phosphate receptor",
                "gene_name": "M6PR",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9NVZ3-1",
                "protein_name": "Adaptin ear-binding coat-associated protein 2",
                "gene_name": "NECAP2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8NC96-1",
                "protein_name": "Adaptin ear-binding coat-associated protein 1",
                "gene_name": "NECAP1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q6UW88-1",
                "protein_name": "Epigen",
                "gene_name": "EPGN",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O14944-1",
                "protein_name": "Proepiregulin",
                "gene_name": "EREG",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P53680-1",
                "protein_name": "AP-2 complex subunit sigma",
                "gene_name": "AP2S1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O94973-1",
                "protein_name": "AP-2 complex subunit alpha-2",
                "gene_name": "AP2A2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q15642-1",
                "protein_name": "Cdc42-interacting protein 4",
                "gene_name": "TRIP10",
                "tax_name": "Human"
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    {
        "title": "Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells.",
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    {
        "title": "The stimulatory action of amphiphysin on dynamin function is dependent on lipid bilayer curvature.",
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        "date": "2004",
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        "record_id": "pubmed.15318165",
        "abstract": "",
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                        "field": "n_linked_glycans",
                        "count": 0
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    {
        "title": "A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains.",
        "journal": "Cell",
        "date": "1992",
        "authors": "Letourneur F, Klausner RD",
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    {
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        "journal": "Nature",
        "date": "2004",
        "authors": "Fotin A, Cheng Y, Sliz P, Grigorieff N, Harrison SC, Kirchhausen T, Walz T",
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        "title": "BAR domains and membrane curvature: bringing your curves to the BAR.",
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        "date": "2005",
        "authors": "Gallop JL, McMahon HT",
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                "name": "Homo sapiens",
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                "common_name": "Human",
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                "reference_species": "Homo sapiens [9606]"
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    {
        "title": "Functional dissection of an AP-2 beta2 appendage-binding sequence within the autosomal recessive hypercholesterolemia protein.",
        "journal": "The Journal of biological chemistry",
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        "authors": "Mishra SK, Keyel PA, Edeling MA, Dupin AL, Owen DJ, Traub LM",
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                    {
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        ]
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    {
        "title": "The small G-protein Arf6GTP recruits the AP-2 adaptor complex to membranes.",
        "journal": "The Journal of biological chemistry",
        "date": "2005",
        "authors": "Paleotti O, Macia E, Luton F, Klein S, Partisani M, Chardin P, Kirchhausen T, Franco M",
        "reference": {
            "type": "PubMed",
            "id": "15802264",
            "url": "https://pubmed.ncbi.nlm.nih.gov/15802264"
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    {
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    {
        "title": "Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction.",
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        "authors": "Regan-Klapisz E, Sorokina I, Voortman J, de Keizer P, Roovers RC, Verheesen P, Urbe S, Fallon L, Fon EA, Verkleij A, Benmerah A, van Bergen en Henegouwen PM",
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                "uniprot_canonical_ac": "P04114-1",
                "protein_name": "Apolipoprotein B-100",
                "gene_name": "APOB",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P59998-1",
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                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "O15144-1",
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                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "Q8N6T3-1",
                "protein_name": "ADP-ribosylation factor GTPase-activating protein 1",
                "gene_name": "ARFGAP1",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P61158-1",
                "protein_name": "Actin-related protein 3",
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                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "O15511-1",
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                "gene_name": "ARPC5",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P61160-1",
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                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "O00401-1",
                "protein_name": "Actin nucleation-promoting factor WASL",
                "gene_name": "WASL",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P25103-1",
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                "tax_name": "Human"
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                "uniprot_canonical_ac": "Q96D71-1",
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                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P53675-1",
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                "uniprot_canonical_ac": "Q5T0N5-1",
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                "tax_name": "Human"
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            },
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                "uniprot_canonical_ac": "Q5VV43-1",
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                "uniprot_canonical_ac": "Q92747-1",
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        ],
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                ],
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        ],
        "mutagenesis": [
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                "start_pos": 1250,
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                "sequence_org": "D",
                "sequence_mut": "A",
                "comment": "Abolishes lipid kinase activity. Affects clathrin distribution when combined with a truncation encompassing the region of clathrin interaction.",
                "evidence": [
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        "title": "Molecular cloning and expression of human keratinocyte proline-rich protein (hKPRP), an epidermal marker isolated from calcium-induced differentiating keratinocytes.",
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    {
        "title": "Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix.",
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                "gene_name": "AVPR2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P04234-1",
                "protein_name": "T-cell surface glycoprotein CD3 delta chain",
                "gene_name": "CD3D",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P09693-1",
                "protein_name": "T-cell surface glycoprotein CD3 gamma chain",
                "gene_name": "CD3G",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8IUR0-1",
                "protein_name": "Trafficking protein particle complex subunit 5",
                "gene_name": "TRAPPC5",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9UBC2-1",
                "protein_name": "Epidermal growth factor receptor substrate 15-like 1",
                "gene_name": "EPS15L1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P98082-1",
                "protein_name": "Disabled homolog 2",
                "gene_name": "DAB2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8IV53-1",
                "protein_name": "DENN domain-containing protein 1C",
                "gene_name": "DENND1C",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8TEH3-1",
                "protein_name": "DENN domain-containing protein 1A",
                "gene_name": "DENND1A",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q13637-1",
                "protein_name": "Ras-related protein Rab-32",
                "gene_name": "RAB32",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O43493-2",
                "protein_name": "Trans-Golgi network integral membrane protein 2",
                "gene_name": "TGOLN2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q86WG5-1",
                "protein_name": "Myotubularin-related protein 13",
                "gene_name": "SBF2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O75379-1",
                "protein_name": "Vesicle-associated membrane protein 4",
                "gene_name": "VAMP4",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q13492-1",
                "protein_name": "Phosphatidylinositol-binding clathrin assembly protein",
                "gene_name": "PICALM",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P51151-1",
                "protein_name": "Ras-related protein Rab-9A",
                "gene_name": "RAB9A",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9BQI5-1",
                "protein_name": "SH3-containing GRB2-like protein 3-interacting protein 1",
                "gene_name": "SGIP1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q16572-1",
                "protein_name": "Vesicular acetylcholine transporter",
                "gene_name": "SLC18A3",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8TB24-1",
                "protein_name": "Ras and Rab interactor 3",
                "gene_name": "RIN3",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "A2RUS2-1",
                "protein_name": "DENN domain-containing protein 3",
                "gene_name": "DENND3",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9NZM3-1",
                "protein_name": "Intersectin-2",
                "gene_name": "ITSN2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P61006-1",
                "protein_name": "Ras-related protein Rab-8A",
                "gene_name": "RAB8A",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P61026-1",
                "protein_name": "Ras-related protein Rab-10",
                "gene_name": "RAB10",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q6IQ22-1",
                "protein_name": "Ras-related protein Rab-12",
                "gene_name": "RAB12",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P98164-1",
                "protein_name": "Low-density lipoprotein receptor-related protein 2",
                "gene_name": "LRP2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9H0U4-1",
                "protein_name": "Ras-related protein Rab-1B",
                "gene_name": "RAB1B",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P51153-1",
                "protein_name": "Ras-related protein Rab-13",
                "gene_name": "RAB13",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9UNF0-1",
                "protein_name": "Protein kinase C and casein kinase substrate in neurons protein 2",
                "gene_name": "PACSIN2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O14526-1",
                "protein_name": "F-BAR domain only protein 1",
                "gene_name": "FCHO1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q99961-1",
                "protein_name": "Endophilin-A2",
                "gene_name": "SH3GL1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P30556-1",
                "protein_name": "Type-1 angiotensin II receptor",
                "gene_name": "AGTR1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q00610-1",
                "protein_name": "Clathrin heavy chain 1",
                "gene_name": "CLTC",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P07550-1",
                "protein_name": "Beta-2 adrenergic receptor",
                "gene_name": "ADRB2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P11142-1",
                "protein_name": "Heat shock cognate 71 kDa protein",
                "gene_name": "HSPA8",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q96B97-1",
                "protein_name": "SH3 domain-containing kinase-binding protein 1",
                "gene_name": "SH3KBP1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P63010-1",
                "protein_name": "AP-2 complex subunit beta",
                "gene_name": "AP2B1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P32121-1",
                "protein_name": "Beta-arrestin-2",
                "gene_name": "ARRB2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P63261-1",
                "protein_name": "Actin, cytoplasmic 2",
                "gene_name": "ACTG1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P50570-1",
                "protein_name": "Dynamin-2",
                "gene_name": "DNM2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q96QF0-1",
                "protein_name": "Rab-3A-interacting protein",
                "gene_name": "RAB3IP",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P49407-1",
                "protein_name": "Beta-arrestin-1",
                "gene_name": "ARRB1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P31749-1",
                "protein_name": "RAC-alpha serine/threonine-protein kinase",
                "gene_name": "AKT1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O14641-1",
                "protein_name": "Segment polarity protein dishevelled homolog DVL-2",
                "gene_name": "DVL2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q60I27-1",
                "protein_name": "ALS2 C-terminal-like protein",
                "gene_name": "ALS2CL",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q92747-1",
                "protein_name": "Actin-related protein 2/3 complex subunit 1A",
                "gene_name": "ARPC1A",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P62330-1",
                "protein_name": "ADP-ribosylation factor 6",
                "gene_name": "ARF6",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q5SW96-1",
                "protein_name": "Low density lipoprotein receptor adapter protein 1",
                "gene_name": "LDLRAP1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P01130-1",
                "protein_name": "Low-density lipoprotein receptor",
                "gene_name": "LDLR",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q96CW1-1",
                "protein_name": "AP-2 complex subunit mu",
                "gene_name": "AP2M1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P31751-1",
                "protein_name": "RAC-beta serine/threonine-protein kinase",
                "gene_name": "AKT2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P20339-1",
                "protein_name": "Ras-related protein Rab-5A",
                "gene_name": "RAB5A",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P49418-1",
                "protein_name": "Amphiphysin",
                "gene_name": "AMPH",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P02786-1",
                "protein_name": "Transferrin receptor protein 1",
                "gene_name": "TFRC",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q01968-1",
                "protein_name": "Inositol polyphosphate 5-phosphatase OCRL",
                "gene_name": "OCRL",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P61106-1",
                "protein_name": "Ras-related protein Rab-14",
                "gene_name": "RAB14",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9ULV1-1",
                "protein_name": "Frizzled-4",
                "gene_name": "FZD4",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q14C86-1",
                "protein_name": "GTPase-activating protein and VPS9 domain-containing protein 1",
                "gene_name": "GAPVD1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O15056-1",
                "protein_name": "Polyphosphatidylinositol phosphatase SYNJ2",
                "gene_name": "SYNJ2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P62820-1",
                "protein_name": "Ras-related protein Rab-1A",
                "gene_name": "RAB1A",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P02787-1",
                "protein_name": "Serotransferrin",
                "gene_name": "TF",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P31150-1",
                "protein_name": "Rab GDP dissociation inhibitor alpha",
                "gene_name": "GDI1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P41221-1",
                "protein_name": "Protein Wnt-5a",
                "gene_name": "WNT5A",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q14964-1",
                "protein_name": "Ras-related protein Rab-39A",
                "gene_name": "RAB39A",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P62979-1",
                "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein",
                "gene_name": "RPS27A",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O00499-1",
                "protein_name": "Myc box-dependent-interacting protein 1",
                "gene_name": "BIN1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P13569-1",
                "protein_name": "Cystic fibrosis transmembrane conductance regulator",
                "gene_name": "CFTR",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P21579-1",
                "protein_name": "Synaptotagmin-1",
                "gene_name": "SYT1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P09496-1",
                "protein_name": "Clathrin light chain A",
                "gene_name": "CLTA",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q6ZUT9-1",
                "protein_name": "DENN domain-containing protein 5B",
                "gene_name": "DENND5B",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8NEG7-1",
                "protein_name": "Protein DENND6B",
                "gene_name": "DENND6B",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q5VZ89-1",
                "protein_name": "DENN domain-containing protein 4C",
                "gene_name": "DENND4C",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O75064-1",
                "protein_name": "DENN domain-containing protein 4B",
                "gene_name": "DENND4B",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q68D51-1",
                "protein_name": "DENN domain-containing protein 2C",
                "gene_name": "DENND2C",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9H6A0-1",
                "protein_name": "DENN domain-containing protein 2D",
                "gene_name": "DENND2D",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q14108-1",
                "protein_name": "Lysosome membrane protein 2",
                "gene_name": "SCARB2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O60331-1",
                "protein_name": "Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma",
                "gene_name": "PIP5K1C",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O43617-1",
                "protein_name": "Trafficking protein particle complex subunit 3",
                "gene_name": "TRAPPC3",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P26374-1",
                "protein_name": "Rab proteins geranylgeranyltransferase component A 2",
                "gene_name": "CHML",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P24386-1",
                "protein_name": "Rab proteins geranylgeranyltransferase component A 1",
                "gene_name": "CHM",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q15042-1",
                "protein_name": "Rab3 GTPase-activating protein catalytic subunit",
                "gene_name": "RAB3GAP1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9BY11-1",
                "protein_name": "Protein kinase C and casein kinase substrate in neurons protein 1",
                "gene_name": "PACSIN1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P51149-1",
                "protein_name": "Ras-related protein Rab-7a",
                "gene_name": "RAB7A",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O75865-1",
                "protein_name": "Trafficking protein particle complex subunit 6A",
                "gene_name": "TRAPPC6A",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9NP72-1",
                "protein_name": "Ras-related protein Rab-18",
                "gene_name": "RAB18",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9H2M9-1",
                "protein_name": "Rab3 GTPase-activating protein non-catalytic subunit",
                "gene_name": "RAB3GAP2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9NP90-1",
                "protein_name": "Ras-related protein Rab-9B",
                "gene_name": "RAB9B",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P78524-1",
                "protein_name": "DENN domain-containing protein 2B",
                "gene_name": "DENND2B",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O43426-1",
                "protein_name": "Polyphosphatidylinositol phosphatase SYNJ1",
                "gene_name": "SYNJ1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P35070-1",
                "protein_name": "Probetacellulin",
                "gene_name": "BTC",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O75061-1",
                "protein_name": "Auxilin",
                "gene_name": "DNAJC6",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q15811-1",
                "protein_name": "Intersectin-1",
                "gene_name": "ITSN1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9UJ41-2",
                "protein_name": "Rab5 GDP/GTP exchange factor",
                "gene_name": "RABGEF1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P01730-1",
                "protein_name": "T-cell surface glycoprotein CD4",
                "gene_name": "CD4",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P0CG47-1",
                "protein_name": "Polyubiquitin-B",
                "gene_name": "UBB",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8TBN0-1",
                "protein_name": "Guanine nucleotide exchange factor for Rab-3A",
                "gene_name": "RAB3IL1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P86790-1",
                "protein_name": "Vacuolar fusion protein CCZ1 homolog B",
                "gene_name": "CCZ1B; CCZ1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P09497-1",
                "protein_name": "Clathrin light chain B",
                "gene_name": "CLTB",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q6IQ26-1",
                "protein_name": "DENN domain-containing protein 5A",
                "gene_name": "DENND5A",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q6P3S1-1",
                "protein_name": "DENN domain-containing protein 1B",
                "gene_name": "DENND1B",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8IWF6-1",
                "protein_name": "Protein DENND6A",
                "gene_name": "DENND6A",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9UL33-1",
                "protein_name": "Trafficking protein particle complex subunit 2-like protein",
                "gene_name": "TRAPPC2L",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P62987-1",
                "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein",
                "gene_name": "UBA52",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q05193-1",
                "protein_name": "Dynamin-1",
                "gene_name": "DNM1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9ULE3-1",
                "protein_name": "DENN domain-containing protein 2A",
                "gene_name": "DENND2A",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9Y6I3-2",
                "protein_name": "Epsin-1",
                "gene_name": "EPN1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P51148-1",
                "protein_name": "Ras-related protein Rab-5C",
                "gene_name": "RAB5C",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q0JRZ9-1",
                "protein_name": "F-BAR domain only protein 2",
                "gene_name": "FCHO2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9UQ16-1",
                "protein_name": "Dynamin-3",
                "gene_name": "DNM3",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P42566-1",
                "protein_name": "Epidermal growth factor receptor substrate 15",
                "gene_name": "EPS15",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O95208-1",
                "protein_name": "Epsin-2",
                "gene_name": "EPN2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P0DI81-1",
                "protein_name": "Trafficking protein particle complex subunit 2",
                "gene_name": "TRAPPC2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8WXE9-1",
                "protein_name": "Stonin-2",
                "gene_name": "STON2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P50395-1",
                "protein_name": "Rab GDP dissociation inhibitor beta",
                "gene_name": "GDI2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P11717-1",
                "protein_name": "Cation-independent mannose-6-phosphate receptor",
                "gene_name": "IGF2R",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9NY64-1",
                "protein_name": "Solute carrier family 2, facilitated glucose transporter member 8",
                "gene_name": "SLC2A8",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q99075-1",
                "protein_name": "Proheparin-binding EGF-like growth factor",
                "gene_name": "HBEGF",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P20645-1",
                "protein_name": "Cation-dependent mannose-6-phosphate receptor",
                "gene_name": "M6PR",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P20336-1",
                "protein_name": "Ras-related protein Rab-3A",
                "gene_name": "RAB3A",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "Q7L1V2-1",
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    {
        "title": "B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK.",
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    {
        "title": "Stonin 2 is an AP-2-dependent endocytic sorting adaptor for synaptotagmin internalization and recycling.",
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    {
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        "title": "Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly.",
        "journal": "Developmental cell",
        "date": "2006",
        "authors": "Edeling MA, Mishra SK, Keyel PA, Steinhauser AL, Collins BM, Roth R, Heuser JE, Owen DJ, Traub LM",
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        "title": "A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling.",
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        "record_id": "pubmed.16798879",
        "abstract": "",
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        "title": "HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors.",
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        "record_id": "pubmed.16880396",
        "abstract": "",
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        "referenced_proteins": [
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                "uniprot_canonical_ac": "P01133-1",
                "protein_name": "Pro-epidermal growth factor",
                "gene_name": "EGF",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q96RF0-1",
                "protein_name": "Sorting nexin-18",
                "gene_name": "SNX18",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8NFH8-1",
                "protein_name": "RalBP1-associated Eps domain-containing protein 2",
                "gene_name": "REPS2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8NBV8-4",
                "protein_name": "Synaptotagmin-8",
                "gene_name": "SYT8",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8N9I0-1",
                "protein_name": "Synaptotagmin-2",
                "gene_name": "SYT2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q86SS6-1",
                "protein_name": "Synaptotagmin-9",
                "gene_name": "SYT9",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P51809-1",
                "protein_name": "Vesicle-associated membrane protein 7",
                "gene_name": "VAMP7",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P52594-1",
                "protein_name": "Arf-GAP domain and FG repeat-containing protein 1",
                "gene_name": "AGFG1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9BT88-1",
                "protein_name": "Synaptotagmin-11",
                "gene_name": "SYT11",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O60641-1",
                "protein_name": "Clathrin coat assembly protein AP180",
                "gene_name": "SNAP91",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O15145-1",
                "protein_name": "Actin-related protein 2/3 complex subunit 3",
                "gene_name": "ARPC3",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9Y5X1-1",
                "protein_name": "Sorting nexin-9",
                "gene_name": "SNX9",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q14247-1",
                "protein_name": "Src substrate cortactin",
                "gene_name": "CTTN",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P15514-1",
                "protein_name": "Amphiregulin",
                "gene_name": "AREG",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O95782-1",
                "protein_name": "AP-2 complex subunit alpha-1",
                "gene_name": "AP2A1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P04114-1",
                "protein_name": "Apolipoprotein B-100",
                "gene_name": "APOB",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P59998-1",
                "protein_name": "Actin-related protein 2/3 complex subunit 4",
                "gene_name": "ARPC4",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O15144-1",
                "protein_name": "Actin-related protein 2/3 complex subunit 2",
                "gene_name": "ARPC2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8N6T3-1",
                "protein_name": "ADP-ribosylation factor GTPase-activating protein 1",
                "gene_name": "ARFGAP1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P61158-1",
                "protein_name": "Actin-related protein 3",
                "gene_name": "ACTR3",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O15511-1",
                "protein_name": "Actin-related protein 2/3 complex subunit 5",
                "gene_name": "ARPC5",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P61160-1",
                "protein_name": "Actin-related protein 2",
                "gene_name": "ACTR2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O00401-1",
                "protein_name": "Actin nucleation-promoting factor WASL",
                "gene_name": "WASL",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P25103-1",
                "protein_name": "Substance-P receptor",
                "gene_name": "TACR1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q96D71-1",
                "protein_name": "RalBP1-associated Eps domain-containing protein 1",
                "gene_name": "REPS1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P53675-1",
                "protein_name": "Clathrin heavy chain 2",
                "gene_name": "CLTCL1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q5T0N5-1",
                "protein_name": "Formin-binding protein 1-like",
                "gene_name": "FNBP1L",
                "tax_name": "Human"
            },
            {
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                "protein_name": "Signal transducing adapter molecule 1",
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                "tax_name": "Human"
            },
            {
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                "protein_name": "Interleukin-7 receptor subunit alpha",
                "gene_name": "IL7R",
                "tax_name": "Human"
            },
            {
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                "protein_name": "Vesicle-associated membrane protein 2",
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                "tax_name": "Human"
            },
            {
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                "protein_name": "Dyslexia-associated protein KIAA0319",
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                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O75146-1",
                "protein_name": "Huntingtin-interacting protein 1-related protein",
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                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O00291-1",
                "protein_name": "Huntingtin-interacting protein 1",
                "gene_name": "HIP1",
                "tax_name": "Human"
            },
            {
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                "protein_name": "Vasopressin-neurophysin 2-copeptin",
                "gene_name": "AVP",
                "tax_name": "Human"
            },
            {
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                "protein_name": "Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha",
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                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9Y6Q2-1",
                "protein_name": "Stonin-1",
                "gene_name": "STON1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9BV40-1",
                "protein_name": "Vesicle-associated membrane protein 8",
                "gene_name": "VAMP8",
                "tax_name": "Human"
            },
            {
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                "protein_name": "Formin-binding protein 1",
                "gene_name": "FNBP1",
                "tax_name": "Human"
            },
            {
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                "protein_name": "Protransforming growth factor alpha",
                "gene_name": "TGFA",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P61020-1",
                "protein_name": "Ras-related protein Rab-5B",
                "gene_name": "RAB5B",
                "tax_name": "Human"
            },
            {
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                "tax_name": "Human"
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            },
            {
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            },
            {
                "uniprot_canonical_ac": "P30518-1",
                "protein_name": "Vasopressin V2 receptor",
                "gene_name": "AVPR2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P04234-1",
                "protein_name": "T-cell surface glycoprotein CD3 delta chain",
                "gene_name": "CD3D",
                "tax_name": "Human"
            },
            {
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                "protein_name": "T-cell surface glycoprotein CD3 gamma chain",
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            },
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                "protein_name": "Epidermal growth factor receptor substrate 15-like 1",
                "gene_name": "EPS15L1",
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            },
            {
                "uniprot_canonical_ac": "P98082-1",
                "protein_name": "Disabled homolog 2",
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                "tax_name": "Human"
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            {
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                "protein_name": "Trans-Golgi network integral membrane protein 2",
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                "tax_name": "Human"
            },
            {
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                "protein_name": "SH3-containing GRB2-like protein 3-interacting protein 1",
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            {
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                "protein_name": "Vesicular acetylcholine transporter",
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            {
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                "tax_name": "Human"
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            {
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                "protein_name": "Low-density lipoprotein receptor-related protein 2",
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                "tax_name": "Human"
            },
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                "gene_name": "PACSIN2",
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                "protein_name": "Type-1 angiotensin II receptor",
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                "protein_name": "Clathrin heavy chain 1",
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            {
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                "protein_name": "Beta-2 adrenergic receptor",
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            {
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                "protein_name": "Heat shock cognate 71 kDa protein",
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                "gene_name": "SH3KBP1",
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            {
                "uniprot_canonical_ac": "P63010-1",
                "protein_name": "AP-2 complex subunit beta",
                "gene_name": "AP2B1",
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            {
                "uniprot_canonical_ac": "P32121-1",
                "protein_name": "Beta-arrestin-2",
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                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "P63261-1",
                "protein_name": "Actin, cytoplasmic 2",
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                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "P49407-1",
                "protein_name": "Beta-arrestin-1",
                "gene_name": "ARRB1",
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                "protein_name": "Segment polarity protein dishevelled homolog DVL-2",
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            {
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                "protein_name": "ADP-ribosylation factor 6",
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            {
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                "protein_name": "Low density lipoprotein receptor adapter protein 1",
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            {
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                "protein_name": "Low-density lipoprotein receptor",
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                "tax_name": "Human"
            },
            {
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                "protein_name": "Ras-related protein Rab-5A",
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            {
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                "protein_name": "Transferrin receptor protein 1",
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                "protein_name": "Inositol polyphosphate 5-phosphatase OCRL",
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                "protein_name": "GTPase-activating protein and VPS9 domain-containing protein 1",
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            {
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            {
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                "protein_name": "Serotransferrin",
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            },
            {
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                "protein_name": "Protein Wnt-5a",
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            },
            {
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                "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein",
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                "protein_name": "Cystic fibrosis transmembrane conductance regulator",
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                "protein_name": "Synaptotagmin-1",
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                "protein_name": "Clathrin light chain A",
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            },
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                "protein_name": "Lysosome membrane protein 2",
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            {
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                "protein_name": "Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma",
                "gene_name": "PIP5K1C",
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            {
                "uniprot_canonical_ac": "Q9BY11-1",
                "protein_name": "Protein kinase C and casein kinase substrate in neurons protein 1",
                "gene_name": "PACSIN1",
                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "O43426-1",
                "protein_name": "Polyphosphatidylinositol phosphatase SYNJ1",
                "gene_name": "SYNJ1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P35070-1",
                "protein_name": "Probetacellulin",
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                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O75061-1",
                "protein_name": "Auxilin",
                "gene_name": "DNAJC6",
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            },
            {
                "uniprot_canonical_ac": "Q15811-1",
                "protein_name": "Intersectin-1",
                "gene_name": "ITSN1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P01730-1",
                "protein_name": "T-cell surface glycoprotein CD4",
                "gene_name": "CD4",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P0CG47-1",
                "protein_name": "Polyubiquitin-B",
                "gene_name": "UBB",
                "tax_name": "Human"
            },
            {
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                "protein_name": "Clathrin light chain B",
                "gene_name": "CLTB",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P62987-1",
                "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein",
                "gene_name": "UBA52",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q05193-1",
                "protein_name": "Dynamin-1",
                "gene_name": "DNM1",
                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "Q9Y6I3-2",
                "protein_name": "Epsin-1",
                "gene_name": "EPN1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P51148-1",
                "protein_name": "Ras-related protein Rab-5C",
                "gene_name": "RAB5C",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q0JRZ9-1",
                "protein_name": "F-BAR domain only protein 2",
                "gene_name": "FCHO2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9UQ16-1",
                "protein_name": "Dynamin-3",
                "gene_name": "DNM3",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P42566-1",
                "protein_name": "Epidermal growth factor receptor substrate 15",
                "gene_name": "EPS15",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O95208-1",
                "protein_name": "Epsin-2",
                "gene_name": "EPN2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8WXE9-1",
                "protein_name": "Stonin-2",
                "gene_name": "STON2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P11717-1",
                "protein_name": "Cation-independent mannose-6-phosphate receptor",
                "gene_name": "IGF2R",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9NY64-1",
                "protein_name": "Solute carrier family 2, facilitated glucose transporter member 8",
                "gene_name": "SLC2A8",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q99075-1",
                "protein_name": "Proheparin-binding EGF-like growth factor",
                "gene_name": "HBEGF",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P20645-1",
                "protein_name": "Cation-dependent mannose-6-phosphate receptor",
                "gene_name": "M6PR",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9NVZ3-1",
                "protein_name": "Adaptin ear-binding coat-associated protein 2",
                "gene_name": "NECAP2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8NC96-1",
                "protein_name": "Adaptin ear-binding coat-associated protein 1",
                "gene_name": "NECAP1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q6UW88-1",
                "protein_name": "Epigen",
                "gene_name": "EPGN",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O14944-1",
                "protein_name": "Proepiregulin",
                "gene_name": "EREG",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P53680-1",
                "protein_name": "AP-2 complex subunit sigma",
                "gene_name": "AP2S1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O94973-1",
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    {
        "title": "Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor.",
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]
