[ { "title": "Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity.", "journal": "Molecular cell", "date": "2007", "authors": "Kim EJ, Kho JH, Kang MR, Um SJ", "reference": { "type": "PubMed", "id": "17964266", "url": "https://pubmed.ncbi.nlm.nih.gov/17964266" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q86WX3-1", "protein_name": "Active regulator of SIRT1", "gene_name": "RPS19BP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96EB6-1", "protein_name": "NAD-dependent protein deacetylase sirtuin-1", "gene_name": "SIRT1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q86WX3", "url": "https://www.uniprot.org/uniprotkb/Q86WX3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.17964266", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "PUMA, a novel proapoptotic gene, is induced by p53.", "journal": "Molecular cell", "date": "2001", "authors": "Nakano K, Vousden KH", "reference": { "type": "PubMed", "id": "11463392", "url": "https://pubmed.ncbi.nlm.nih.gov/11463392" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q96KQ4-1", "protein_name": "Apoptosis-stimulating of p53 protein 1", "gene_name": "PPP1R13B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q01094-1", "protein_name": "Transcription factor E2F1", "gene_name": "E2F1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q07817-1", "protein_name": "Bcl-2-like protein 1", "gene_name": "BCL2L1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43521-1", "protein_name": "Bcl-2-like protein 11", "gene_name": "BCL2L11", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15350-1", 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"n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2001", "authors": "Han J, Flemington C, Houghton AB, Gu Z, Zambetti GP, Lutz RJ, Zhu L, Chittenden T", "reference": { "type": "PubMed", "id": "11572983", "url": "https://pubmed.ncbi.nlm.nih.gov/11572983" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q96KQ4-1", "protein_name": "Apoptosis-stimulating of p53 protein 1", "gene_name": "PPP1R13B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q01094-1", "protein_name": "Transcription factor E2F1", "gene_name": "E2F1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15350-1", "protein_name": "Tumor protein p73", "gene_name": "TP73", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H3D4-1", "protein_name": "Tumor protein 63", "gene_name": "TP63", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14188-1", "protein_name": "Transcription factor Dp-2", "gene_name": "TFDP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14186-1", "protein_name": "Transcription factor Dp-1", "gene_name": "TFDP1", "tax_name": "Human" }, { 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"phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 14 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 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"uniprot_canonical_ac": "P41182-1", "protein_name": "B-cell lymphoma 6 protein", "gene_name": "BCL6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92597-1", "protein_name": "Protein NDRG1", "gene_name": "NDRG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BZR8-1", "protein_name": "Apoptosis facilitator Bcl-2-like protein 14", "gene_name": "BCL2L14", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96FX8-1", "protein_name": "p53 apoptosis effector related to PMP-22", "gene_name": "PERP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24386-1", "protein_name": "Rab proteins geranylgeranyltransferase component A 1", "gene_name": "CHM", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13625-1", "protein_name": "Apoptosis-stimulating of p53 protein 2", "gene_name": "TP53BP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04637-1", "protein_name": "Cellular tumor antigen p53", "gene_name": "TP53", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q96KQ4", "url": "https://www.uniprot.org/uniprotkb/Q96KQ4" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11919562", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 14 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys.", "journal": "The Journal of biological chemistry", "date": "1992", "authors": "Seabra MC, Goldstein JL, Sudhof TC, Brown MS", "reference": { "type": "PubMed", "id": "1321151", "url": "https://pubmed.ncbi.nlm.nih.gov/1321151" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q96KQ4-1", "protein_name": "Apoptosis-stimulating of p53 protein 1", "gene_name": "PPP1R13B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P53611-1", "protein_name": "Geranylgeranyl transferase type-2 subunit beta", "gene_name": "RABGGTB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92696-1", "protein_name": "Geranylgeranyl transferase type-2 subunit alpha", "gene_name": "RABGGTA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q53FA7-1", "protein_name": "Quinone oxidoreductase PIG3", "gene_name": "TP53I3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15392-1", 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"Q86X29-1", "protein_name": "Lipolysis-stimulated lipoprotein receptor", "gene_name": "LSR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38571-1", "protein_name": "Lysosomal acid lipase/cholesteryl ester hydrolase", "gene_name": "LIPA", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15118-1", "protein_name": "NPC intracellular cholesterol transporter 1", "gene_name": "NPC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PIU2-1", "protein_name": "Neutral cholesterol ester hydrolase 1", "gene_name": "NCEH1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75908-1", "protein_name": "Sterol O-acyltransferase 2", "gene_name": "SOAT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35610-1", "protein_name": "Sterol O-acyltransferase 1", "gene_name": "SOAT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00610-1", "protein_name": "Clathrin heavy chain 1", "gene_name": "CLTC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63010-1", "protein_name": "AP-2 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"tax_name": "Human" }, { "uniprot_canonical_ac": "P53680-1", "protein_name": "AP-2 complex subunit sigma", "gene_name": "AP2S1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94973-1", "protein_name": "AP-2 complex subunit alpha-2", "gene_name": "AP2A2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95782", "url": "https://www.uniprot.org/uniprotkb/O95782" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.12464675", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 19 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { 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"table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network.", "journal": "Cell structure and function", "date": "2003-10", "authors": "Nakatsu Fubito, Ohno Hiroshi", "reference": { "type": "PubMed", "id": "14745134", "url": "https://pubmed.ncbi.nlm.nih.gov/14745134" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O95782-1", "protein_name": "AP-2 complex subunit alpha-1", "gene_name": "AP2A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P17427-1", "protein_name": "AP-2 complex subunit alpha-2", "gene_name": "Ap2a2", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "P18484-1", "protein_name": "AP-2 complex subunit alpha-2", "gene_name": "Ap2a2", "tax_name": "Rat" }, { "uniprot_canonical_ac": "P62744-1", "protein_name": "AP-2 complex subunit sigma", "gene_name": "Ap2s1", "tax_name": "Rat" }, { "uniprot_canonical_ac": "P17426-1", "protein_name": "AP-2 complex subunit alpha-1", "gene_name": "Ap2a1", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "P84091-1", "protein_name": "AP-2 complex subunit mu", "gene_name": "Ap2m1", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "P62944-1", "protein_name": "AP-2 complex subunit beta", "gene_name": "Ap2b1", "tax_name": "Rat" }, { "uniprot_canonical_ac": "P84092-1", "protein_name": "AP-2 complex subunit mu", "gene_name": "Ap2m1", "tax_name": "Rat" }, { "uniprot_canonical_ac": "P63010-1", "protein_name": "AP-2 complex subunit beta", "gene_name": "AP2B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96CW1-1", "protein_name": "AP-2 complex subunit mu", "gene_name": "AP2M1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9DBG3-1", "protein_name": "AP-2 complex subunit beta", "gene_name": "Ap2b1", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "P62743-1", "protein_name": "AP-2 complex subunit sigma", "gene_name": "Ap2s1", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "P53680-1", "protein_name": "AP-2 complex subunit sigma", "gene_name": "AP2S1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94973-1", "protein_name": "AP-2 complex subunit alpha-2", "gene_name": "AP2A2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95782", "url": "https://www.uniprot.org/uniprotkb/O95782" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.14745134", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 14 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pits.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Michaely P, Li WP, Anderson RG, Cohen JC, Hobbs HH", "reference": { "type": "PubMed", "id": "15166224", "url": "https://pubmed.ncbi.nlm.nih.gov/15166224" }, "referenced_glycans": 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"tax_name": "Human" }, { "uniprot_canonical_ac": "O75908-1", "protein_name": "Sterol O-acyltransferase 2", "gene_name": "SOAT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35610-1", "protein_name": "Sterol O-acyltransferase 1", "gene_name": "SOAT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00610-1", "protein_name": "Clathrin heavy chain 1", "gene_name": "CLTC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63010-1", "protein_name": "AP-2 complex subunit beta", "gene_name": "AP2B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NBP7-1", "protein_name": "Proprotein convertase subtilisin/kexin type 9", "gene_name": "PCSK9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5SW96-1", "protein_name": "Low density lipoprotein receptor adapter protein 1", "gene_name": "LDLRAP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01130-1", "protein_name": "Low-density lipoprotein receptor", "gene_name": "LDLR", "tax_name": "Human" }, { "uniprot_canonical_ac": 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[9606]" } ], "record_id": "pubmed.15166224", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 20 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "ARF1 regulates Nef-induced CD4 degradation.", "journal": "Current biology : CB", "date": "2004", "authors": "Faure J, Stalder R, Borel C, Sobo K, Piguet V, Demaurex N, Gruenberg J, Trono D", "reference": { "type": "PubMed", "id": "15202998", "url": "https://pubmed.ncbi.nlm.nih.gov/15202998" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O95782-1", "protein_name": "AP-2 complex subunit alpha-1", "gene_name": "AP2A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P84077-1", "protein_name": "ADP-ribosylation factor 1", "gene_name": "ARF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63010-1", "protein_name": "AP-2 complex subunit beta", "gene_name": "AP2B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96CW1-1", "protein_name": "AP-2 complex subunit mu", "gene_name": "AP2M1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P06239-1", "protein_name": "Tyrosine-protein kinase Lck", "gene_name": "LCK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UI12-1", "protein_name": "V-type proton ATPase subunit H", "gene_name": "ATP6V1H", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01730-1", "protein_name": "T-cell surface glycoprotein 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Jones C, Li WP, Michaely P, Herz J, Gerard RD, Cohen JC, Hobbs HH", "reference": { "type": "PubMed", "id": "16179341", "url": "https://pubmed.ncbi.nlm.nih.gov/16179341" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O95782-1", "protein_name": "AP-2 complex subunit alpha-1", "gene_name": "AP2A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04114-1", "protein_name": "Apolipoprotein B-100", "gene_name": "APOB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86X29-1", "protein_name": "Lipolysis-stimulated lipoprotein receptor", "gene_name": "LSR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38571-1", "protein_name": "Lysosomal acid lipase/cholesteryl ester hydrolase", "gene_name": "LIPA", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15118-1", "protein_name": "NPC intracellular cholesterol transporter 1", "gene_name": "NPC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PIU2-1", "protein_name": "Neutral cholesterol ester 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Effect of clathrin assembly lymphoid myeloid leukemia protein depletion on clathrin coat formation.", "journal": "Traffic", "date": "2005", "authors": "Meyerholz Anika, Hinrichsen Lars, Groos Stephanie, Esk Peter-Christopher, Brandes Gudrun, Ungewickell Ernst J", "reference": { "type": "PubMed", "id": "16262731", "url": "https://pubmed.ncbi.nlm.nih.gov/16262731" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O95782-1", "protein_name": "AP-2 complex subunit alpha-1", "gene_name": "AP2A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13492-1", "protein_name": "Phosphatidylinositol-binding clathrin assembly protein", "gene_name": "PICALM", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95782", "url": "https://www.uniprot.org/uniprotkb/O95782" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.16262731", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Liou HL, Dixit SS, Xu S, Tint GS, Stock AM, Lobel P", "reference": { "type": "PubMed", "id": "17018531", "url": "https://pubmed.ncbi.nlm.nih.gov/17018531" }, 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"protein_name": "Carboxylesterase 3", "gene_name": "CES3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09496-1", "protein_name": "Clathrin light chain A", "gene_name": "CLTA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61916-1", "protein_name": "NPC intracellular cholesterol transporter 2", "gene_name": "NPC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Z0J0-1", "protein_name": "NPC intracellular cholesterol transporter 2", "gene_name": "Npc2", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "P53680-1", "protein_name": "AP-2 complex subunit sigma", "gene_name": "AP2S1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94973-1", "protein_name": "AP-2 complex subunit alpha-2", "gene_name": "AP2A2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95782", "url": "https://www.uniprot.org/uniprotkb/O95782" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "reported", "site_category_dict": { "reported": true, "automatic_literature_mining": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": { "label": "iCn3D", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?bcifid=5KWY&bu=0&command=select+.D:135;+center+selection;+zoom+selection" }, "start_pos": 135, "start_aa": "Asn", "end_pos": 135, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn135", "evidence": [ { "id": "P61916", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61916#ptm_processing" }, { "id": "19159218", "database": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/19159218" }, { "id": "27551080", "database": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/27551080" }, { "id": "5KWY", "database": "PDB", "url": "https://www.rcsb.org/sequence/5KWY" }, { 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"Asn", "end_pos": 58, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn58", "evidence": [ { "id": "P61916", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61916#ptm_processing" }, { "id": "27551080", "database": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/27551080" }, { "id": "5KWY", "database": "PDB", "url": "https://www.rcsb.org/sequence/5KWY" }, { "id": "17018531", "database": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/17018531" }, { "id": "23090970", "database": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/23090970" }, { "id": "GLY_000143", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000143" }, { "id": "15542393", "database": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/15542393" }, { "id": "GLY_000481", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000481" } ], "mining_tool": "RLIMS-G_1.0;GlycoSiteMiner_1.0", "mining_tool_list": [ { "label": "RLIMS-G_1.0" }, { "label": "GlycoSiteMiner_1.0" } ], "filter_code": "001000000000000000000.00010000000000.00.01000", "uniprot_canonical_ac": "P61916-1" } ], "record_id": "pubmed.17018531", "abstract": "", "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 20 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "icn3d_view.label", "icn3d_view.url", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl", "mining_tool", "filter_code", "uniprot_canonical_ac" ] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "icn3d_view.label", "icn3d_view.url", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl", "mining_tool", "filter_code", "uniprot_canonical_ac" ] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "icn3d_view.label", "icn3d_view.url", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl", "mining_tool", "filter_code", "uniprot_canonical_ac" ] } ] }, { "title": "Cloning and expression of cDNA encoding human lysosomal acid lipase/cholesteryl ester hydrolase. Similarities to gastric and lingual lipases.", "journal": "The Journal of biological chemistry", "date": "1991", "authors": "Anderson RA, Sando GN", "reference": { "type": "PubMed", "id": "1718995", "url": "https://pubmed.ncbi.nlm.nih.gov/1718995" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O95782-1", "protein_name": "AP-2 complex subunit alpha-1", "gene_name": "AP2A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04114-1", "protein_name": "Apolipoprotein B-100", "gene_name": "APOB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86X29-1", "protein_name": "Lipolysis-stimulated lipoprotein receptor", "gene_name": "LSR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38571-1", "protein_name": "Lysosomal acid lipase/cholesteryl ester hydrolase", "gene_name": "LIPA", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15118-1", "protein_name": "NPC intracellular cholesterol transporter 1", "gene_name": "NPC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PIU2-1", "protein_name": "Neutral cholesterol ester hydrolase 1", "gene_name": "NCEH1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75908-1", "protein_name": "Sterol O-acyltransferase 2", "gene_name": "SOAT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35610-1", "protein_name": "Sterol O-acyltransferase 1", "gene_name": "SOAT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00610-1", "protein_name": "Clathrin heavy chain 1", "gene_name": "CLTC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63010-1", "protein_name": "AP-2 complex subunit beta", "gene_name": "AP2B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NBP7-1", "protein_name": "Proprotein convertase subtilisin/kexin type 9", "gene_name": "PCSK9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5SW96-1", "protein_name": "Low density lipoprotein receptor adapter protein 1", "gene_name": "LDLRAP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01130-1", "protein_name": "Low-density lipoprotein receptor", "gene_name": "LDLR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96CW1-1", "protein_name": "AP-2 complex subunit mu", "gene_name": "AP2M1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UWW8-1", "protein_name": "Carboxylesterase 3", "gene_name": "CES3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09496-1", "protein_name": "Clathrin light chain A", "gene_name": "CLTA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61916-1", "protein_name": "NPC intracellular cholesterol transporter 2", "gene_name": "NPC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P53680-1", "protein_name": "AP-2 complex subunit sigma", "gene_name": "AP2S1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94973-1", "protein_name": "AP-2 complex subunit alpha-2", "gene_name": "AP2A2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95782", "url": "https://www.uniprot.org/uniprotkb/O95782" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.1718995", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 19 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Zhang DW, Lagace TA, Garuti R, Zhao Z, McDonald M, Horton JD, Cohen JC, Hobbs HH", "reference": { "type": "PubMed", "id": "17452316", "url": "https://pubmed.ncbi.nlm.nih.gov/17452316" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O95782-1", "protein_name": "AP-2 complex subunit alpha-1", "gene_name": "AP2A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04114-1", "protein_name": "Apolipoprotein B-100", "gene_name": "APOB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P98155-1", "protein_name": "Very low-density lipoprotein receptor", "gene_name": "VLDLR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86X29-1", "protein_name": "Lipolysis-stimulated lipoprotein receptor", "gene_name": "LSR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38571-1", "protein_name": "Lysosomal acid lipase/cholesteryl ester hydrolase", "gene_name": "LIPA", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15118-1", "protein_name": "NPC intracellular cholesterol transporter 1", "gene_name": "NPC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PIU2-1", "protein_name": "Neutral cholesterol ester hydrolase 1", "gene_name": "NCEH1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75908-1", "protein_name": "Sterol O-acyltransferase 2", "gene_name": "SOAT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35610-1", "protein_name": "Sterol O-acyltransferase 1", "gene_name": "SOAT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WY64-1", "protein_name": "E3 ubiquitin-protein ligase MYLIP", "gene_name": "MYLIP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13133-1", "protein_name": "Oxysterols receptor LXR-alpha", "gene_name": "NR1H3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00610-1", "protein_name": "Clathrin heavy chain 1", "gene_name": "CLTC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55055-1", "protein_name": "Oxysterols receptor LXR-beta", "gene_name": "NR1H2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63010-1", "protein_name": "AP-2 complex subunit beta", "gene_name": "AP2B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NBP7-1", "protein_name": "Proprotein convertase subtilisin/kexin type 9", "gene_name": "PCSK9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5SW96-1", "protein_name": "Low density lipoprotein receptor adapter protein 1", "gene_name": "LDLRAP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01130-1", "protein_name": "Low-density lipoprotein receptor", "gene_name": "LDLR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96CW1-1", "protein_name": "AP-2 complex subunit mu", "gene_name": "AP2M1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UWW8-1", "protein_name": "Carboxylesterase 3", "gene_name": "CES3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09496-1", "protein_name": "Clathrin light chain A", "gene_name": "CLTA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61916-1", "protein_name": "NPC intracellular cholesterol transporter 2", "gene_name": "NPC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P53680-1", "protein_name": "AP-2 complex subunit sigma", "gene_name": "AP2S1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94973-1", "protein_name": "AP-2 complex subunit alpha-2", "gene_name": "AP2A2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95782", "url": "https://www.uniprot.org/uniprotkb/O95782" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.17452316", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 27 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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"Lipolysis stimulated lipoprotein receptor: a novel molecular link between hyperlipidemia, weight gain, and atherosclerosis in mice.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Yen FT, Roitel O, Bonnard L, Notet V, Pratte D, Stenger C, Magueur E, Bihain BE", "reference": { "type": "PubMed", "id": "18644789", "url": "https://pubmed.ncbi.nlm.nih.gov/18644789" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O95782-1", "protein_name": "AP-2 complex subunit alpha-1", "gene_name": "AP2A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04114-1", "protein_name": "Apolipoprotein B-100", "gene_name": "APOB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P98155-1", "protein_name": "Very low-density lipoprotein receptor", "gene_name": "VLDLR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q0VD83-4", "protein_name": "Apolipoprotein B receptor", "gene_name": "APOBR", "tax_name": "Human" }, { "uniprot_canonical_ac": 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"uniprot_canonical_ac": "P09496-1", "protein_name": "Clathrin light chain A", "gene_name": "CLTA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61916-1", "protein_name": "NPC intracellular cholesterol transporter 2", "gene_name": "NPC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P53680-1", "protein_name": "AP-2 complex subunit sigma", "gene_name": "AP2S1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94973-1", "protein_name": "AP-2 complex subunit alpha-2", "gene_name": "AP2A2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95782", "url": "https://www.uniprot.org/uniprotkb/O95782" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.18644789", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": 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Yahagi N, Ohashi K, Amemiya-Kudo M, Nakagawa Y, Nagai R, Kadowaki T, Osuga J, Ishibashi S", "reference": { "type": "PubMed", "id": "18782767", "url": "https://pubmed.ncbi.nlm.nih.gov/18782767" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O95782-1", "protein_name": "AP-2 complex subunit alpha-1", "gene_name": "AP2A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04114-1", "protein_name": "Apolipoprotein B-100", "gene_name": "APOB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8BLF1-1", "protein_name": "Neutral cholesterol ester hydrolase 1", "gene_name": "Nceh1", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q86X29-1", "protein_name": "Lipolysis-stimulated lipoprotein receptor", "gene_name": "LSR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38571-1", "protein_name": "Lysosomal acid lipase/cholesteryl ester hydrolase", "gene_name": "LIPA", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15118-1", "protein_name": "NPC 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"gene_name": "LDLRAP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01130-1", "protein_name": "Low-density lipoprotein receptor", "gene_name": "LDLR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96CW1-1", "protein_name": "AP-2 complex subunit mu", "gene_name": "AP2M1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UWW8-1", "protein_name": "Carboxylesterase 3", "gene_name": "CES3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09496-1", "protein_name": "Clathrin light chain A", "gene_name": "CLTA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61916-1", "protein_name": "NPC intracellular cholesterol transporter 2", "gene_name": "NPC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P53680-1", "protein_name": "AP-2 complex subunit sigma", "gene_name": "AP2S1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94973-1", "protein_name": "AP-2 complex subunit alpha-2", "gene_name": "AP2A2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", 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[] } ] }, { "title": "The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway.", "journal": "Journal of cell science", "date": "2008-12-15", "authors": "Lau Alan W, Chou Margaret M", "reference": { "type": "PubMed", "id": "19033387", "url": "https://pubmed.ncbi.nlm.nih.gov/19033387" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O95782-1", "protein_name": "AP-2 complex subunit alpha-1", "gene_name": "AP2A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63010-1", "protein_name": "AP-2 complex subunit beta", "gene_name": "AP2B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96CW1-1", "protein_name": "AP-2 complex subunit mu", "gene_name": "AP2M1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P53680-1", "protein_name": "AP-2 complex subunit sigma", "gene_name": "AP2S1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94973-1", "protein_name": "AP-2 complex subunit 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"count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { 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Endocrinology and metabolism", "date": "2009", "authors": "Chang TY, Li BL, Chang CC, Urano Y", "reference": { "type": "PubMed", "id": "19141679", "url": "https://pubmed.ncbi.nlm.nih.gov/19141679" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O95782-1", "protein_name": "AP-2 complex subunit alpha-1", "gene_name": "AP2A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04114-1", "protein_name": "Apolipoprotein B-100", "gene_name": "APOB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86X29-1", "protein_name": "Lipolysis-stimulated lipoprotein receptor", "gene_name": "LSR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38571-1", "protein_name": "Lysosomal acid lipase/cholesteryl ester hydrolase", "gene_name": "LIPA", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15118-1", "protein_name": "NPC intracellular cholesterol transporter 1", "gene_name": "NPC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PIU2-1", "protein_name": "Neutral cholesterol ester hydrolase 1", "gene_name": "NCEH1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75908-1", "protein_name": "Sterol O-acyltransferase 2", "gene_name": "SOAT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35610-1", "protein_name": "Sterol O-acyltransferase 1", "gene_name": "SOAT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00610-1", "protein_name": "Clathrin heavy chain 1", "gene_name": "CLTC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63010-1", "protein_name": "AP-2 complex subunit beta", "gene_name": "AP2B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NBP7-1", "protein_name": "Proprotein convertase subtilisin/kexin type 9", "gene_name": "PCSK9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5SW96-1", "protein_name": "Low density lipoprotein receptor adapter protein 1", "gene_name": "LDLRAP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01130-1", "protein_name": "Low-density lipoprotein receptor", "gene_name": "LDLR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96CW1-1", "protein_name": "AP-2 complex subunit mu", "gene_name": "AP2M1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UWW8-1", "protein_name": "Carboxylesterase 3", "gene_name": "CES3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09496-1", "protein_name": "Clathrin light chain A", "gene_name": "CLTA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61916-1", "protein_name": "NPC intracellular cholesterol transporter 2", "gene_name": "NPC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P53680-1", "protein_name": "AP-2 complex subunit sigma", "gene_name": "AP2S1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94973-1", "protein_name": "AP-2 complex subunit alpha-2", "gene_name": "AP2A2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95782", "url": "https://www.uniprot.org/uniprotkb/O95782" } ], 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"The Biochemical journal", "date": "2009", "authors": "Duff CJ, Scott MJ, Kirby IT, Hutchinson SE, Martin SL, Hooper NM", "reference": { "type": "PubMed", "id": "19196236", "url": "https://pubmed.ncbi.nlm.nih.gov/19196236" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O95782-1", "protein_name": "AP-2 complex subunit alpha-1", "gene_name": "AP2A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04114-1", "protein_name": "Apolipoprotein B-100", "gene_name": "APOB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86X29-1", "protein_name": "Lipolysis-stimulated lipoprotein receptor", "gene_name": "LSR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38571-1", "protein_name": "Lysosomal acid lipase/cholesteryl ester hydrolase", "gene_name": "LIPA", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15118-1", "protein_name": "NPC intracellular cholesterol transporter 1", "gene_name": "NPC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PIU2-1", "protein_name": "Neutral cholesterol ester hydrolase 1", "gene_name": "NCEH1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75908-1", "protein_name": "Sterol O-acyltransferase 2", "gene_name": "SOAT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35610-1", "protein_name": "Sterol O-acyltransferase 1", "gene_name": "SOAT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00610-1", "protein_name": "Clathrin heavy chain 1", "gene_name": "CLTC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63010-1", "protein_name": "AP-2 complex subunit beta", "gene_name": "AP2B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NBP7-1", "protein_name": "Proprotein convertase subtilisin/kexin type 9", "gene_name": "PCSK9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5SW96-1", "protein_name": "Low density lipoprotein receptor adapter protein 1", "gene_name": "LDLRAP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01130-1", "protein_name": "Low-density 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"https://www.uniprot.org/uniprotkb/O95782" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.19196236", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 19 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], 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"o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor.", "journal": "Science (New York, N.Y.)", "date": "2009", "authors": "Zelcer N, Hong C, Boyadjian R, Tontonoz P", "reference": { "type": "PubMed", "id": "19520913", "url": "https://pubmed.ncbi.nlm.nih.gov/19520913" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O95782-1", "protein_name": "AP-2 complex subunit alpha-1", "gene_name": "AP2A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P98155-1", "protein_name": "Very low-density lipoprotein receptor", "gene_name": "VLDLR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19793-1", "protein_name": "Retinoic acid receptor RXR-alpha", "gene_name": "RXRA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P28702-1", "protein_name": "Retinoic acid receptor RXR-beta", "gene_name": "RXRB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WY64-1", "protein_name": "E3 ubiquitin-protein ligase MYLIP", "gene_name": "MYLIP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13133-1", "protein_name": "Oxysterols receptor LXR-alpha", "gene_name": "NR1H3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00610-1", "protein_name": "Clathrin heavy chain 1", "gene_name": "CLTC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55055-1", "protein_name": "Oxysterols receptor LXR-beta", "gene_name": "NR1H2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63010-1", "protein_name": "AP-2 complex subunit beta", "gene_name": "AP2B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NBP7-1", "protein_name": "Proprotein convertase subtilisin/kexin type 9", "gene_name": "PCSK9", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01130-1", "protein_name": "Low-density lipoprotein receptor", "gene_name": "LDLR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96CW1-1", "protein_name": "AP-2 complex subunit mu", "gene_name": "AP2M1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal 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Insensitive to MYLIP-triggered degradation; when associated with R-811; R-816 and A-839.", "evidence": [ { "database": "UniProtKB", "id": "P01130", "url": "https://www.uniprot.org/uniprotkb/P01130" }, { "database": "PubMed", "id": "19520913", "url": "https://pubmed.ncbi.nlm.nih.gov/19520913" } ], "uniprot_canonical_ac": "P01130-1" }, { "start_pos": 839, "end_pos": 839, "sequence_org": "C", "sequence_mut": "A", "comment": "No change. Insensitive to MYLIP-triggered degradation; when associated with R-830. Insensitive to MYLIP-triggered degradation; when associated with R-816 and R-830. 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"count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol.", "journal": "Cell", "date": "2009", "authors": "Kwon HJ, Abi-Mosleh L, Wang ML, Deisenhofer J, Goldstein JL, Brown MS, Infante RE", "reference": { "type": 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"count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl", "mining_tool", "filter_code", "uniprot_canonical_ac" ] } ] }, { "title": "Wnt5a regulates distinct signalling pathways by binding to Frizzled2.", "journal": "The EMBO journal", "date": "2010", "authors": "Sato A, Yamamoto H, Sakane H, Koyama H, Kikuchi A", "reference": { "type": "PubMed", "id": "19910923", "url": "https://pubmed.ncbi.nlm.nih.gov/19910923" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O95782-1", "protein_name": "AP-2 complex subunit alpha-1", "gene_name": "AP2A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q01973-1", "protein_name": "Inactive tyrosine-protein kinase 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"count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages.", "journal": "Circulation research", "date": "2010", "authors": "Igarashi M, Osuga J, Uozaki H, Sekiya M, Nagashima S, Takahashi M, Takase S, Takanashi M, Li Y, Ohta K, Kumagai M, Nishi M, Hosokawa M, Fledelius C, Jacobsen P, Yagyu H, Fukayama M, Nagai R, Kadowaki T, Ohashi K, Ishibashi S", "reference": { "type": "PubMed", "id": "20947831", "url": "https://pubmed.ncbi.nlm.nih.gov/20947831" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O95782-1", "protein_name": "AP-2 complex subunit alpha-1", "gene_name": "AP2A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04114-1", "protein_name": "Apolipoprotein B-100", "gene_name": "APOB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86X29-1", "protein_name": "Lipolysis-stimulated lipoprotein 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degradation of the low density lipoprotein receptor (LDLR) by the E3 ubiquitin ligase inducible Degrader of the LDLR (IDOL).", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Sorrentino V, Scheer L, Santos A, Reits E, Bleijlevens B, Zelcer N", "reference": { "type": "PubMed", "id": "21734303", "url": "https://pubmed.ncbi.nlm.nih.gov/21734303" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O95782-1", "protein_name": "AP-2 complex subunit alpha-1", "gene_name": "AP2A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P98155-1", "protein_name": "Very low-density lipoprotein receptor", "gene_name": "VLDLR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WY64-1", "protein_name": "E3 ubiquitin-protein ligase MYLIP", "gene_name": "MYLIP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13133-1", "protein_name": "Oxysterols receptor LXR-alpha", "gene_name": "NR1H3", "tax_name": "Human" }, { "uniprot_canonical_ac": 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"count": 0 } ], "sort_fields": [] } ] }, { "title": "Post-transcriptional regulation of lipoprotein receptors by the E3-ubiquitin ligase inducible degrader of the low-density lipoprotein receptor.", "journal": "Current opinion in lipidology", "date": "2012", "authors": "Sorrentino V, Zelcer N", "reference": { "type": "PubMed", "id": "22510808", "url": "https://pubmed.ncbi.nlm.nih.gov/22510808" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O95782-1", "protein_name": "AP-2 complex subunit alpha-1", "gene_name": "AP2A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P98155-1", "protein_name": "Very low-density lipoprotein receptor", "gene_name": "VLDLR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WY64-1", "protein_name": "E3 ubiquitin-protein ligase MYLIP", "gene_name": "MYLIP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13133-1", "protein_name": "Oxysterols receptor LXR-alpha", "gene_name": "NR1H3", "tax_name": "Human" }, { 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"uniprot_canonical_ac": "O95782-1", "protein_name": "AP-2 complex subunit alpha-1", "gene_name": "AP2A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04114-1", "protein_name": "Apolipoprotein B-100", "gene_name": "APOB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86X29-1", "protein_name": "Lipolysis-stimulated lipoprotein receptor", "gene_name": "LSR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38571-1", "protein_name": "Lysosomal acid lipase/cholesteryl ester hydrolase", "gene_name": "LIPA", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15118-1", "protein_name": "NPC intracellular cholesterol transporter 1", "gene_name": "NPC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PIU2-1", "protein_name": "Neutral cholesterol ester hydrolase 1", "gene_name": "NCEH1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75908-1", "protein_name": "Sterol O-acyltransferase 2", "gene_name": "SOAT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35610-1", "protein_name": "Sterol O-acyltransferase 1", "gene_name": "SOAT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00610-1", "protein_name": "Clathrin heavy chain 1", "gene_name": "CLTC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63010-1", "protein_name": "AP-2 complex subunit beta", "gene_name": "AP2B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NBP7-1", "protein_name": "Proprotein convertase subtilisin/kexin type 9", "gene_name": "PCSK9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5SW96-1", "protein_name": "Low density lipoprotein receptor adapter protein 1", "gene_name": "LDLRAP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01130-1", "protein_name": "Low-density lipoprotein receptor", "gene_name": "LDLR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96CW1-1", "protein_name": "AP-2 complex subunit mu", "gene_name": "AP2M1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UWW8-1", "protein_name": "Carboxylesterase 3", "gene_name": "CES3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09496-1", "protein_name": "Clathrin light chain A", "gene_name": "CLTA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61916-1", "protein_name": "NPC intracellular cholesterol transporter 2", "gene_name": "NPC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P53680-1", "protein_name": "AP-2 complex subunit sigma", "gene_name": "AP2S1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94973-1", "protein_name": "AP-2 complex subunit alpha-2", "gene_name": "AP2A2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95782", "url": "https://www.uniprot.org/uniprotkb/O95782" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.26474739", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 19 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Raftlin controls lipopolysaccharide-induced TLR4 internalization and TICAM-1 signaling in a cell type-specific manner.", "journal": "J. Immunol.", "date": "2016", "authors": "Tatematsu M, Yoshida R, Morioka Y, Ishii N, Funami K, Watanabe A, Saeki K, Seya T, Matsumoto M", "reference": { "type": "PubMed", "id": "27022195", "url": "https://pubmed.ncbi.nlm.nih.gov/27022195" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O95782-1", "protein_name": "AP-2 complex subunit alpha-1", "gene_name": "AP2A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14699-1", "protein_name": "Raftlin", "gene_name": "RFTN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00206-1", "protein_name": "Toll-like receptor 4", "gene_name": "TLR4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00610-1", "protein_name": "Clathrin heavy chain 1", "gene_name": "CLTC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63010-1", "protein_name": "AP-2 complex subunit beta", "gene_name": "AP2B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6A0D4-1", "protein_name": "Raftlin", "gene_name": "Rftn1", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q8CHX7-1", "protein_name": "Raftlin-2", "gene_name": "Rftn2", "tax_name": "Mouse" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95782", "url": "https://www.uniprot.org/uniprotkb/O95782" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.27022195", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 7 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Stoichiometric binding of low density lipoprotein (LDL) and monoclonal antibodies to LDL receptors in a solid phase assay.", "journal": "The Journal of biological chemistry", "date": "1989", "authors": "Van Driel IR, Brown MS, Goldstein JL", "reference": { "type": "PubMed", "id": "2722848", "url": "https://pubmed.ncbi.nlm.nih.gov/2722848" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O95782-1", "protein_name": "AP-2 complex subunit alpha-1", "gene_name": "AP2A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04114-1", "protein_name": "Apolipoprotein B-100", "gene_name": "APOB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86X29-1", "protein_name": "Lipolysis-stimulated lipoprotein receptor", "gene_name": "LSR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38571-1", "protein_name": "Lysosomal acid lipase/cholesteryl ester hydrolase", "gene_name": "LIPA", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15118-1", "protein_name": "NPC intracellular cholesterol transporter 1", "gene_name": "NPC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PIU2-1", "protein_name": "Neutral cholesterol ester hydrolase 1", "gene_name": "NCEH1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75908-1", "protein_name": "Sterol O-acyltransferase 2", "gene_name": "SOAT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35610-1", "protein_name": "Sterol O-acyltransferase 1", "gene_name": "SOAT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00610-1", "protein_name": "Clathrin heavy chain 1", "gene_name": "CLTC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63010-1", "protein_name": "AP-2 complex subunit beta", "gene_name": "AP2B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NBP7-1", "protein_name": "Proprotein convertase subtilisin/kexin type 9", "gene_name": "PCSK9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5SW96-1", "protein_name": "Low density lipoprotein receptor adapter protein 1", "gene_name": "LDLRAP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01130-1", "protein_name": "Low-density lipoprotein receptor", "gene_name": "LDLR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96CW1-1", "protein_name": "AP-2 complex subunit mu", "gene_name": "AP2M1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UWW8-1", "protein_name": "Carboxylesterase 3", "gene_name": "CES3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09496-1", "protein_name": "Clathrin light chain A", "gene_name": "CLTA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61916-1", "protein_name": "NPC intracellular cholesterol transporter 2", "gene_name": "NPC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P53680-1", "protein_name": "AP-2 complex subunit sigma", "gene_name": "AP2S1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94973-1", "protein_name": "AP-2 complex subunit alpha-2", "gene_name": "AP2A2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95782", "url": "https://www.uniprot.org/uniprotkb/O95782" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.2722848", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 19 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": 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"protein_name": "BTB/POZ domain-containing protein 8", "gene_name": "Btbd8", "tax_name": "Rat" }, { "uniprot_canonical_ac": "P17426-1", "protein_name": "AP-2 complex subunit alpha-1", "gene_name": "Ap2a1", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "P63010-1", "protein_name": "AP-2 complex subunit beta", "gene_name": "AP2B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9DBG3-1", "protein_name": "AP-2 complex subunit beta", "gene_name": "Ap2b1", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q5XKL5-3", "protein_name": "BTB/POZ domain-containing protein 8", "gene_name": "BTBD8", "tax_name": "Human" }, { "uniprot_canonical_ac": "D3YUB6-2", "protein_name": "BTB/POZ domain-containing protein 8", "gene_name": "Btbd8", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "O94973-1", "protein_name": "AP-2 complex subunit alpha-2", "gene_name": "AP2A2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95782", "url": "https://www.uniprot.org/uniprotkb/O95782" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.29262337", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 9 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 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"o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Molecular cloning of novel transcripts of the adaptor-related protein complex 2 alpha 1 subunit (AP2A1) gene, using Next-Generation Sequencing.", "journal": "Gene", "date": "2018", "authors": "Adamopoulos PG, Kontos CK, Diamantopoulos MA, Scorilas A", "reference": { "type": "PubMed", "id": "30081190", "url": "https://pubmed.ncbi.nlm.nih.gov/30081190" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O95782-1", "protein_name": "AP-2 complex subunit alpha-1", "gene_name": "AP2A1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95782", "url": "https://www.uniprot.org/uniprotkb/O95782" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.30081190", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } 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"count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Role of PCSK9 Inhibitors in Patients with Familial Hypercholesterolemia.", "journal": "Endocrinology and metabolism (Seoul, Korea)", "date": "2021", "authors": "Tomlinson B, Patil NG, Fok M, Lam CWK", "reference": { "type": "PubMed", "id": "33866776", "url": "https://pubmed.ncbi.nlm.nih.gov/33866776" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O95782-1", "protein_name": "AP-2 complex subunit alpha-1", 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"Clathrin light chain A", "gene_name": "CLTA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61916-1", "protein_name": "NPC intracellular cholesterol transporter 2", "gene_name": "NPC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P53680-1", "protein_name": "AP-2 complex subunit sigma", "gene_name": "AP2S1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94973-1", "protein_name": "AP-2 complex subunit alpha-2", "gene_name": "AP2A2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95782", "url": "https://www.uniprot.org/uniprotkb/O95782" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.33866776", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 19 } ], 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Cheng Donghui, Lee Alex H, Kadash-Edmondson Kathryn E, Champhekar Ameya, Puig-Saus Cristina, Ribas Antoni, Prins Robert M, Seet Christopher S, Crooks Gay M, Witte Owen N, Xing Yi", "reference": { "type": "PubMed", "id": "37192158", "url": "https://pubmed.ncbi.nlm.nih.gov/37192158" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O95782-1", "protein_name": "AP-2 complex subunit alpha-1", "gene_name": "AP2A1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95782", "url": "https://www.uniprot.org/uniprotkb/O95782" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.37192158", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ 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Death usually occurs within the first year of life." }, "synonyms": [ { "id": "DOID:14497", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:14497", "name": "Acid esterase deficiency", "description": "" }, { "id": "DOID:14497", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:14497", "name": "Acid lipase deficiency", "description": "" }, { "id": "DOID:14497", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:14497", "name": "Wolman xanthomatosis", "description": "" }, { "id": "DOID:14497", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:14497", "name": "Wolman's disease", "description": "" }, { "id": "DOID:14497", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:14497", "name": "Wolman's or triglyceride storage type III disease", "description": "" }, { "id": "DOID:14497", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:14497", "name": "Xanthomatosis, familial", "description": "" }, { "id": "DOID:14497", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:14497", "name": "acute infantile lysosomal acid lipase deficiency", "description": "" }, { "id": "DOID:14497", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:14497", "name": "complete LAL deficiency", "description": "" }, { "id": "DOID:14497", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:14497", "name": "complete LIPA deficiency", "description": "" }, { "id": "DOID:14497", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:14497", "name": "complete cholesterol ester hydrolase deficiency", "description": "" }, { "id": "DOID:14497", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:14497", "name": "complete lysosomal acid lipase deficiency", "description": "" }, { "id": "MONDO:0019148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019148", "name": "Wolman disease", "description": "Wolman disease represents the most severe manifestation of lysosomal acid lipase deficiency. Milder phenotypes as a whole are referred to as cholesterol ester storage disease. The acid lipase enzyme plays an essential role in lysosomal hydrolysis of both esterified cholesterol and triglycerides of lipoproteic origin. In Wolman disease, the rarest form of acid lipase deficiency, these lipids accumulate in most tissues." }, { "id": "MONDO:0019148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019148", "name": "lysosomal acid lipase deficiency", "description": "" }, { "id": "MONDO:0019148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019148", "name": "Wolman disease with hypolipoproteinemia and acanthocytosis", "description": "" }, { "id": "MONDO:0019148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019148", "name": "Wolman's disease", "description": "" }, { "id": "MONDO:0019148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019148", "name": "familial xanthomatosis", "description": "" }, { "id": "MONDO:0019148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019148", "name": "liposomal acid lipase deficiency, Wolman type", "description": "" }, { "id": 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], "unlinked_id_list": [], "evidence": [ { "id": "0080217", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080217" }, { "id": "0080217", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080217" } ] }, { "disease_id": "DOID:14502", "recommended_name": { "id": "DOID:14502", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:14502", "name": "cholesterol ester storage disease", "description": "A lysosomal acid lipase deficiency characterized by onset in childhood or later of progressive accumulation of cholesteryl esters and triglycerides primarily in the liver and spleen." }, "synonyms": [ { "id": "DOID:14502", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:14502", "name": "CESD", "description": "" }, { "id": "DOID:14502", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:14502", "name": "partial LAL deficiency", "description": "" }, { "id": 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"MIM", "url": "https://www.omim.org/entry/278000", "name": "Cholesteryl ester storage disease", "description": "Cholesteryl ester storage disease" } ], "unlinked_id_list": [], "evidence": [ { "id": "14502", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:14502" }, { "id": "14502", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:14502" } ] }, { "disease_id": "DOID:14497", "recommended_name": { "id": "DOID:14497", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:14497", "name": "Wolman disease", "description": "A lysosomal acid lipase deficiency characterized by infantile onset of rapidly progressive accumulation of cholesteryl esters and triglycerides throughout the body, resulting in hepatosplenomegaly, severe malnutrition, jaundice, vomiting, diarrhea, steatorrhea. Death usually occurs within the first year of life." }, "synonyms": [ { "id": "DOID:14497", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:14497", "name": "Acid esterase deficiency", "description": "" }, { "id": "DOID:14497", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:14497", "name": "Acid lipase deficiency", "description": "" }, { "id": "DOID:14497", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:14497", "name": "Wolman xanthomatosis", "description": "" }, { "id": "DOID:14497", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:14497", "name": "Wolman's disease", "description": "" }, { "id": "DOID:14497", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:14497", "name": "Wolman's or triglyceride storage type III disease", "description": "" }, { "id": "DOID:14497", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:14497", "name": "Xanthomatosis, familial", "description": "" }, { "id": "DOID:14497", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:14497", "name": "acute infantile lysosomal acid lipase deficiency", "description": "" }, { "id": "DOID:14497", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:14497", "name": "complete LAL deficiency", "description": "" }, { "id": "DOID:14497", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:14497", "name": "complete LIPA deficiency", "description": "" }, { "id": "DOID:14497", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:14497", "name": "complete cholesterol ester hydrolase deficiency", "description": "" }, { "id": "DOID:14497", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:14497", "name": "complete lysosomal acid lipase deficiency", "description": "" }, { "id": "MONDO:0019148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019148", "name": "Wolman disease", "description": "Wolman disease represents the most severe manifestation of lysosomal acid lipase deficiency. Milder phenotypes as a whole are referred to as cholesterol ester storage disease. The acid lipase enzyme plays an essential role in lysosomal hydrolysis of both esterified cholesterol and triglycerides of lipoproteic origin. In Wolman disease, the rarest form of acid lipase deficiency, these lipids accumulate in most tissues." }, { "id": "MONDO:0019148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019148", "name": "lysosomal acid lipase deficiency", "description": "" }, { "id": "MONDO:0019148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019148", "name": "Wolman disease with hypolipoproteinemia and acanthocytosis", "description": "" }, { "id": "MONDO:0019148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019148", "name": "Wolman's disease", "description": "" }, { "id": "MONDO:0019148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019148", "name": "familial xanthomatosis", "description": "" }, { "id": "MONDO:0019148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019148", "name": "liposomal acid lipase deficiency, Wolman type", "description": "" }, { "id": "MIM:620151", "resource": "MIM", "url": "https://www.omim.org/entry/620151", "name": "Wolman disease", "description": "Wolman disease" } ], "unlinked_id_list": [], "evidence": [ { "id": "14497", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:14497" }, { "id": "14497", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:14497" } ] } ], "keywords": [ "ebi", "germline", "disease" ], "filter_code": "000000000010000000000.00000000000000.000000000001000000.00001.10.000.000", "uniprot_canonical_ac": "P38571-1" } ], "record_id": "pubmed.8146180", "abstract": "", "glycosylation": [], "mutagenesis": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 19 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { 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light chain A", "gene_name": "CLTA", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75907-1", "protein_name": "Diacylglycerol O-acyltransferase 1", "gene_name": "DGAT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6ZPD8-1", "protein_name": "Diacylglycerol O-acyltransferase 2-like protein 6", "gene_name": "DGAT2L6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NST1-1", "protein_name": "1-acylglycerol-3-phosphate O-acyltransferase PNPLA3", "gene_name": "PNPLA3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96AD5-1", "protein_name": "Patatin-like phospholipase domain-containing protein 2", "gene_name": "PNPLA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6E213-1", "protein_name": "Acyl-CoA wax alcohol acyltransferase 2", "gene_name": "AWAT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61916-1", "protein_name": "NPC intracellular cholesterol transporter 2", "gene_name": "NPC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P53680-1", "protein_name": "AP-2 complex subunit sigma", "gene_name": "AP2S1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94973-1", "protein_name": "AP-2 complex subunit alpha-2", "gene_name": "AP2A2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99685-1", "protein_name": "Monoglyceride lipase", "gene_name": "MGLL", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95782", "url": "https://www.uniprot.org/uniprotkb/O95782" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.9756920", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 26 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { 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variants.", "journal": "Molecular genetics & genomic medicine", "date": "2023-02", "authors": "Daou Melissa, Souaid Mirna, Yammine Tony, Khneisser Issam, Mansour Hicham, Salem Nabiha, Nemr Antony, Awwad Johnny, Moukarzel Adib, Farra Chantal", "reference": { "type": "PubMed", "id": "36680390", "url": "https://pubmed.ncbi.nlm.nih.gov/36680390" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P00966-1", "protein_name": "Argininosuccinate synthase", "gene_name": "ASS1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P00966", "url": "https://www.uniprot.org/uniprotkb/P00966" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.36680390", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": 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