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J. 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"uniprot_canonical_ac": "Q9JHZ2-1", "protein_name": "Mineralization regulator ANKH", "gene_name": "Ankh", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "P22413-1", "protein_name": "Ectonucleotide pyrophosphatase/phosphodiesterase family member 1", "gene_name": "ENPP1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9HCJ1", "url": "https://www.uniprot.org/uniprotkb/Q9HCJ1" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.35147247", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] 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"field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Genetic associations of brain structural networks in schizophrenia: a preliminary study.", "journal": "Biological psychiatry", "date": "2010", "authors": "Jagannathan K, Calhoun VD, Gelernter J, Stevens MC, Liu J, Bolognani F, Windemuth A, Ruano G, Assaf M, Pearlson GD", "reference": { "type": "PubMed", "id": "20691427", "url": "https://pubmed.ncbi.nlm.nih.gov/20691427" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9BWW9-1", "protein_name": "Apolipoprotein L5", "gene_name": "APOL5", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9BWW9", "url": "https://www.uniprot.org/uniprotkb/Q9BWW9" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.20691427", "abstract": "", 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"protein_name": "Glutamate receptor 1", "gene_name": "GRIA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBR2-1", "protein_name": "Cathepsin Z", "gene_name": "CTSZ", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95406-1", "protein_name": "Protein cornichon homolog 1", "gene_name": "CNIH1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75396-1", "protein_name": "Vesicle-trafficking protein SEC22b", "gene_name": "SEC22B", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95487-1", "protein_name": "Protein transport protein Sec24B", "gene_name": "SEC24B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6B6-1", "protein_name": "Small COPII coat GTPase SAR1B", "gene_name": "SAR1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01135-1", "protein_name": "Protransforming growth factor alpha", "gene_name": "TGFA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P53634-1", "protein_name": "Dipeptidyl peptidase 1", "gene_name": "CTSC", "tax_name": "Human" }, { 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"protein_name": "Alpha-1-antitrypsin", "gene_name": "SERPINA1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P15514", "url": "https://www.uniprot.org/uniprotkb/P15514" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.16129679", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 33 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Cargo selectivity of the ERGIC-53/MCFD2 transport receptor complex.", "journal": "Traffic (Copenhagen, Denmark)", "date": "2006", "authors": "Nyfeler B, Zhang B, Ginsburg D, Kaufman RJ, Hauri HP", "reference": { "type": "PubMed", "id": "17010120", "url": "https://pubmed.ncbi.nlm.nih.gov/17010120" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P15514-1", "protein_name": "Amphiregulin", "gene_name": "AREG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49257-1", "protein_name": "Protein ERGIC-53", "gene_name": "LMAN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42261-1", "protein_name": "Glutamate receptor 1", "gene_name": "GRIA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBR2-1", "protein_name": "Cathepsin Z", "gene_name": "CTSZ", "tax_name": "Human" }, { "uniprot_canonical_ac": 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"uniprot_canonical_ac": "Q13190-1", "protein_name": "Syntaxin-5", "gene_name": "STX5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5JRA6-1", "protein_name": "Transport and Golgi organization protein 1 homolog", "gene_name": "MIA3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q02388-1", "protein_name": "Collagen alpha-1(VII) chain", "gene_name": "COL7A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12259-1", "protein_name": "Coagulation factor V", "gene_name": "F5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15328-1", "protein_name": "Folate receptor alpha", "gene_name": "FOLR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P53992-1", "protein_name": "Protein transport protein Sec24C", "gene_name": "SEC24C", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96PC5-3", "protein_name": "Melanoma inhibitory activity protein 2", "gene_name": "MIA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HCU5-1", "protein_name": "Guanine nucleotide-exchange 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"referenced_proteins", "table_stats": [ { "field": "total", "count": 33 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", 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"uniprot_canonical_ac": "O94855-1", "protein_name": "Protein transport protein Sec24D", "gene_name": "SEC24D", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95486-1", "protein_name": "Protein transport protein Sec24A", "gene_name": "SEC24A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01009-1", "protein_name": "Alpha-1-antitrypsin", "gene_name": "SERPINA1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P15514", "url": "https://www.uniprot.org/uniprotkb/P15514" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.18283111", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 33 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { 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"glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors.", "journal": "Science (New York, N.Y.)", "date": "2009", "authors": "Schwenk J, Harmel N, Zolles G, Bildl W, Kulik A, Heimrich B, Chisaka O, Jonas P, Schulte U, Fakler B, Klocker N", "reference": { "type": "PubMed", "id": "19265014", "url": "https://pubmed.ncbi.nlm.nih.gov/19265014" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P15514-1", "protein_name": "Amphiregulin", "gene_name": "AREG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19491-1", "protein_name": "Glutamate receptor 2", "gene_name": "Gria2", "tax_name": "Rat" }, { "uniprot_canonical_ac": "Q71RJ2-1", "protein_name": "Voltage-dependent calcium channel gamma-2 subunit", "gene_name": "Cacng2", "tax_name": "Rat" }, { "uniprot_canonical_ac": "D0Q0Y7-1", "protein_name": "Protein cornichon homolog 3", "gene_name": "Cnih3", "tax_name": "Rat" }, { "uniprot_canonical_ac": "P62957-1", "protein_name": "Voltage-dependent calcium channel gamma-7 subunit", "gene_name": "Cacng7", "tax_name": "Rat" }, { "uniprot_canonical_ac": "Q5BJU5-1", "protein_name": "Protein cornichon homolog 2", "gene_name": "Cnih2", "tax_name": "Rat" }, { "uniprot_canonical_ac": "P49257-1", "protein_name": "Protein ERGIC-53", "gene_name": "LMAN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42261-1", "protein_name": "Glutamate receptor 1", "gene_name": "GRIA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBR2-1", "protein_name": "Cathepsin Z", "gene_name": 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"Human" }, { "uniprot_canonical_ac": "P53634-1", "protein_name": "Dipeptidyl peptidase 1", "gene_name": "CTSC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PI25-1", "protein_name": "Protein cornichon homolog 2", "gene_name": "CNIH2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8TBE1-1", "protein_name": "Protein cornichon homolog 3", "gene_name": "CNIH3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HAT1-1", "protein_name": "Protein ERGIC-53-like", "gene_name": "LMAN1L", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H0V9-1", "protein_name": "VIP36-like protein", "gene_name": "LMAN2L", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q12907-1", "protein_name": "Vesicular integral-membrane protein VIP36", "gene_name": "LMAN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NI22-1", "protein_name": "Multiple coagulation factor deficiency protein 2", "gene_name": "MCFD2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49755-1", "protein_name": "Transmembrane emp24 domain-containing protein 10", "gene_name": "TMED10", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14653-1", "protein_name": "Golgi SNAP receptor complex member 2", "gene_name": "GOSR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00451-1", "protein_name": "Coagulation factor VIII", "gene_name": "F8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19492-1", "protein_name": "Glutamate receptor 3", "gene_name": "Gria3", "tax_name": "Rat" }, { "uniprot_canonical_ac": "Q8VHW5-1", "protein_name": "Voltage-dependent calcium channel gamma-8 subunit", "gene_name": "Cacng8", "tax_name": "Rat" }, { "uniprot_canonical_ac": "P19490-1", "protein_name": "Glutamate receptor 1", "gene_name": "Gria1", "tax_name": "Rat" }, { "uniprot_canonical_ac": "P19493-1", "protein_name": "Glutamate receptor 4", "gene_name": "Gria4", "tax_name": "Rat" }, { "uniprot_canonical_ac": "Q8VHX0-1", "protein_name": "Voltage-dependent calcium channel gamma-3 subunit", "gene_name": 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reticulum exit sites.", "journal": "Cell", "date": "2009", "authors": "Saito K, Chen M, Bard F, Chen S, Zhou H, Woodley D, Polischuk R, Schekman R, Malhotra V", "reference": { "type": "PubMed", "id": "19269366", "url": "https://pubmed.ncbi.nlm.nih.gov/19269366" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P15514-1", "protein_name": "Amphiregulin", "gene_name": "AREG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49257-1", "protein_name": "Protein ERGIC-53", "gene_name": "LMAN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42261-1", "protein_name": "Glutamate receptor 1", "gene_name": "GRIA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBR2-1", "protein_name": "Cathepsin Z", "gene_name": "CTSZ", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95406-1", "protein_name": "Protein cornichon homolog 1", "gene_name": "CNIH1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75396-1", "protein_name": "Vesicle-trafficking protein 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"uniprot_canonical_ac": "Q15436-1", "protein_name": "Protein transport protein Sec23A", "gene_name": "SEC23A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15363-1", "protein_name": "Transmembrane emp24 domain-containing protein 2", "gene_name": "TMED2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94855-1", "protein_name": "Protein transport protein Sec24D", "gene_name": "SEC24D", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95486-1", "protein_name": "Protein transport protein Sec24A", "gene_name": "SEC24A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01009-1", "protein_name": "Alpha-1-antitrypsin", "gene_name": "SERPINA1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P15514", "url": "https://www.uniprot.org/uniprotkb/P15514" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.19269366", "abstract": "", 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Cell. Biol.", "date": "1991", "authors": "Cook P W, Mattox P A, Keeble W W, Pittelkow M R, Plowman G D, Shoyab M, Adelman J P, Shipley G D", "reference": { "type": "PubMed", "id": "2017164", "url": "https://pubmed.ncbi.nlm.nih.gov/2017164" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P15514-1", "protein_name": "Amphiregulin", "gene_name": "AREG", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P15514", "url": "https://www.uniprot.org/uniprotkb/P15514" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.2017164", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { 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"tax_name": "Human" }, { "uniprot_canonical_ac": "O14653-1", "protein_name": "Golgi SNAP receptor complex member 2", "gene_name": "GOSR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00451-1", "protein_name": "Coagulation factor VIII", "gene_name": "F8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13190-1", "protein_name": "Syntaxin-5", "gene_name": "STX5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5JRA6-1", "protein_name": "Transport and Golgi organization protein 1 homolog", "gene_name": "MIA3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q02388-1", "protein_name": "Collagen alpha-1(VII) chain", "gene_name": "COL7A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12259-1", "protein_name": "Coagulation factor V", "gene_name": "F5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15328-1", "protein_name": "Folate receptor alpha", "gene_name": "FOLR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P53992-1", "protein_name": "Protein transport 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"tax_name": "Human" }, { "uniprot_canonical_ac": "P01009-1", "protein_name": "Alpha-1-antitrypsin", "gene_name": "SERPINA1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P15514", "url": "https://www.uniprot.org/uniprotkb/P15514" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.20477988", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 33 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": 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"protein_name": "Protransforming growth factor alpha", "gene_name": "TGFA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P53634-1", "protein_name": "Dipeptidyl peptidase 1", "gene_name": "CTSC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PI25-1", "protein_name": "Protein cornichon homolog 2", "gene_name": "CNIH2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8TBE1-1", "protein_name": "Protein cornichon homolog 3", "gene_name": "CNIH3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y698-1", "protein_name": "Voltage-dependent calcium channel gamma-2 subunit", "gene_name": "CACNG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HAT1-1", "protein_name": "Protein ERGIC-53-like", "gene_name": "LMAN1L", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H0V9-1", "protein_name": "VIP36-like protein", "gene_name": "LMAN2L", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q12907-1", "protein_name": "Vesicular integral-membrane protein VIP36", "gene_name": 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"protein_name": "Transport and Golgi organization protein 1 homolog", "gene_name": "MIA3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q02388-1", "protein_name": "Collagen alpha-1(VII) chain", "gene_name": "COL7A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12259-1", "protein_name": "Coagulation factor V", "gene_name": "F5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15328-1", "protein_name": "Folate receptor alpha", "gene_name": "FOLR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P53992-1", "protein_name": "Protein transport protein Sec24C", "gene_name": "SEC24C", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96PC5-3", "protein_name": "Melanoma inhibitory activity protein 2", "gene_name": "MIA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HCU5-1", "protein_name": "Guanine nucleotide-exchange factor SEC12", "gene_name": "PREB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P13987-1", "protein_name": "CD59 glycoprotein", "gene_name": 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"sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": 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interaction with TANGO1 at endoplasmic reticulum exit sites.", "journal": "Molecular biology of the cell", "date": "2011", "authors": "Saito K, Yamashiro K, Ichikawa Y, Erlmann P, Kontani K, Malhotra V, Katada T", "reference": { "type": "PubMed", "id": "21525241", "url": "https://pubmed.ncbi.nlm.nih.gov/21525241" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P15514-1", "protein_name": "Amphiregulin", "gene_name": "AREG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49257-1", "protein_name": "Protein ERGIC-53", "gene_name": "LMAN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42261-1", "protein_name": "Glutamate receptor 1", "gene_name": "GRIA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBR2-1", "protein_name": "Cathepsin Z", "gene_name": "CTSZ", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95406-1", "protein_name": "Protein cornichon homolog 1", "gene_name": "CNIH1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75396-1", "protein_name": "Vesicle-trafficking protein SEC22b", "gene_name": "SEC22B", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95487-1", "protein_name": "Protein transport protein Sec24B", "gene_name": "SEC24B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6B6-1", "protein_name": "Small COPII coat GTPase SAR1B", "gene_name": "SAR1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01135-1", "protein_name": "Protransforming growth factor alpha", "gene_name": "TGFA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P53634-1", "protein_name": "Dipeptidyl peptidase 1", "gene_name": "CTSC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PI25-1", "protein_name": "Protein cornichon homolog 2", "gene_name": "CNIH2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8TBE1-1", "protein_name": "Protein cornichon homolog 3", "gene_name": "CNIH3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HAT1-1", "protein_name": "Protein ERGIC-53-like", "gene_name": 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"CD59 glycoprotein", "gene_name": "CD59", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15436-1", "protein_name": "Protein transport protein Sec23A", "gene_name": "SEC23A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15363-1", "protein_name": "Transmembrane emp24 domain-containing protein 2", "gene_name": "TMED2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94855-1", "protein_name": "Protein transport protein Sec24D", "gene_name": "SEC24D", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95486-1", "protein_name": "Protein transport protein Sec24A", "gene_name": "SEC24A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01009-1", "protein_name": "Alpha-1-antitrypsin", "gene_name": "SERPINA1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P15514", "url": "https://www.uniprot.org/uniprotkb/P15514" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens 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U.S.A.", "date": "1988", "authors": "Shoyab M, McDonald V L, Bradley J G, Todaro G J", "reference": { "type": "PubMed", "id": "3413110", "url": "https://pubmed.ncbi.nlm.nih.gov/3413110" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P15514-1", "protein_name": "Amphiregulin", "gene_name": "AREG", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P15514", "url": "https://www.uniprot.org/uniprotkb/P15514" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.3413110", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", 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Evidence that amphiregulin acts exclusively through the epidermal growth factor receptor at the surface of human epithelial cells.", "journal": "J. Biol. Chem.", "date": "1993", "authors": "Johnson G R, Kannan B, Shoyab M, Stromberg K", "reference": { "type": "PubMed", "id": "7679104", "url": "https://pubmed.ncbi.nlm.nih.gov/7679104" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P15514-1", "protein_name": "Amphiregulin", "gene_name": "AREG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00533-1", "protein_name": "Epidermal growth factor receptor", "gene_name": "EGFR", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P15514", "url": "https://www.uniprot.org/uniprotkb/P15514" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.7679104", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The recycling of ERGIC-53 in the early secretory pathway. ERGIC-53 carries a cytosolic endoplasmic reticulum-exit determinant interacting with COPII.", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Kappeler F, Klopfenstein DR, Foguet M, Paccaud JP, Hauri HP", "reference": { "type": "PubMed", "id": "9395526", "url": "https://pubmed.ncbi.nlm.nih.gov/9395526" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P15514-1", "protein_name": "Amphiregulin", "gene_name": "AREG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49257-1", "protein_name": "Protein ERGIC-53", "gene_name": "LMAN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42261-1", "protein_name": "Glutamate receptor 1", "gene_name": "GRIA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBR2-1", "protein_name": "Cathepsin Z", "gene_name": "CTSZ", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95406-1", "protein_name": "Protein cornichon homolog 1", "gene_name": "CNIH1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75396-1", "protein_name": "Vesicle-trafficking protein SEC22b", "gene_name": "SEC22B", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95487-1", "protein_name": "Protein transport protein Sec24B", "gene_name": "SEC24B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6B6-1", "protein_name": "Small COPII coat GTPase SAR1B", "gene_name": "SAR1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01135-1", "protein_name": "Protransforming growth factor alpha", "gene_name": "TGFA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P53634-1", "protein_name": "Dipeptidyl peptidase 1", "gene_name": "CTSC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PI25-1", "protein_name": "Protein cornichon homolog 2", "gene_name": "CNIH2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8TBE1-1", "protein_name": "Protein cornichon homolog 3", "gene_name": "CNIH3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HAT1-1", "protein_name": "Protein 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"protein_name": "CD59 glycoprotein", "gene_name": "CD59", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15436-1", "protein_name": "Protein transport protein Sec23A", "gene_name": "SEC23A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15363-1", "protein_name": "Transmembrane emp24 domain-containing protein 2", "gene_name": "TMED2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94855-1", "protein_name": "Protein transport protein Sec24D", "gene_name": "SEC24D", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95486-1", "protein_name": "Protein transport protein Sec24A", "gene_name": "SEC24A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01009-1", "protein_name": "Alpha-1-antitrypsin", "gene_name": "SERPINA1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P15514", "url": "https://www.uniprot.org/uniprotkb/P15514" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": 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"uniprot_canonical_ac": "Q6PI25-1", "protein_name": "Protein cornichon homolog 2", "gene_name": "CNIH2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8TBE1-1", "protein_name": "Protein cornichon homolog 3", "gene_name": "CNIH3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HAT1-1", "protein_name": "Protein ERGIC-53-like", "gene_name": "LMAN1L", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H0V9-1", "protein_name": "VIP36-like protein", "gene_name": "LMAN2L", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q12907-1", "protein_name": "Vesicular integral-membrane protein VIP36", "gene_name": "LMAN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NI22-1", "protein_name": "Multiple coagulation factor deficiency protein 2", "gene_name": "MCFD2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49755-1", "protein_name": "Transmembrane emp24 domain-containing protein 10", "gene_name": "TMED10", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14653-1", 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Disrupts interaction with SEC23A. Disrupts interaction with COPG1 and association with coatomer; when associated with 215-A-A-216.", "evidence": [ { "database": "UniProtKB", "id": "P49755", "url": "https://www.uniprot.org/uniprotkb/P49755" }, { "database": "PubMed", "id": "9472029", "url": "https://pubmed.ncbi.nlm.nih.gov/9472029" }, { "database": "PubMed", "id": "11056392", "url": "https://pubmed.ncbi.nlm.nih.gov/11056392" }, { "database": "PubMed", "id": "10761932", "url": "https://pubmed.ncbi.nlm.nih.gov/10761932" } ], "uniprot_canonical_ac": "P49755-1" }, { "start_pos": 215, "end_pos": 216, "sequence_org": "KK", "sequence_mut": "AA", "comment": "Significant reduction in binding to COPG1. 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Biol. Chem.", "date": "1999", "authors": "Oppermann M, Mack M, Proudfoot AE, Olbrich H", "reference": { "type": "PubMed", "id": "10085131", "url": "https://pubmed.ncbi.nlm.nih.gov/10085131" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P25098-1", "protein_name": "G protein-coupled receptor kinase 2", "gene_name": "GRK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P51681-1", "protein_name": "C-C chemokine receptor type 5", "gene_name": "CCR5", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P25098", "url": "https://www.uniprot.org/uniprotkb/P25098" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 336, "end_pos": 336, "sequence_org": "S", "sequence_mut": "A", "comment": "APO-RANTES-stimulated phosphorylation reduced by 15%; APO-RANTES-stimulated phosphorylation reduced by 30-50%; when associated with A-337 or A-342 or A-349; APO-RANTES-stimulated phosphorylation reduced by 80%; when associated with A-337 and A-342 or A-349; No APO-RANTES-stimulated phosphorylation; when associated with A-337; A-342 and A349; abolishes interaction with ARRB2; when associated with S-337; S-342 and S-349.", "evidence": [ { "database": "UniProtKB", "id": "P51681", "url": "https://www.uniprot.org/uniprotkb/P51681" }, { "database": "PubMed", "id": "10085131", "url": "https://pubmed.ncbi.nlm.nih.gov/10085131" }, { "database": "PubMed", "id": "11448957", "url": "https://pubmed.ncbi.nlm.nih.gov/11448957" } ], "uniprot_canonical_ac": "P51681-1" }, { "start_pos": 337, "end_pos": 337, "sequence_org": "S", "sequence_mut": "A", "comment": "APO-RANTES-stimulated phosphorylation reduced by 18%; APO-RANTES-stimulated phosphorylation reduced by 30-50% on APO-RANTES stimulation; when associated with A-336 or A-342 or A-349; APO-RANTES-stimulated phosphorylation reduced by 80%; when associated with A-336 and A-342 or A-349; No APO-RANTES-stimulated phosphorylation; when associated with A-336; A-342 and A349; abolishes interaction with ARRB2; when associated with S-336; S-342 and S-349.", "evidence": [ { "database": "UniProtKB", "id": "P51681", "url": "https://www.uniprot.org/uniprotkb/P51681" }, { "database": "PubMed", "id": "10085131", "url": "https://pubmed.ncbi.nlm.nih.gov/10085131" }, { "database": "PubMed", "id": "11448957", "url": "https://pubmed.ncbi.nlm.nih.gov/11448957" } ], "uniprot_canonical_ac": "P51681-1" }, { "start_pos": 342, "end_pos": 342, "sequence_org": "S", "sequence_mut": "A", "comment": "APO-RANTES-stimulated phosphorylation reduced by 42%. 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extracellular signal-regulated kinases.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Pitcher JA, Tesmer JJ, Freeman JL, Capel WD, Stone WC, Lefkowitz RJ", "reference": { "type": "PubMed", "id": "10574913", "url": "https://pubmed.ncbi.nlm.nih.gov/10574913" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P25098-1", "protein_name": "G protein-coupled receptor kinase 2", "gene_name": "GRK2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P25098", "url": "https://www.uniprot.org/uniprotkb/P25098" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "phosphorylation": [ { "start_pos": 670, "end_pos": 670, "kinase_uniprot_canonical_ac": "P27361-1", "kinase_gene_name": "MAPK3", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P25098", "url": 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"count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { 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Cell physiology", "date": "2008", "authors": "Murthy KS, Mahavadi S, Huang J, Zhou H, Sriwai W", "reference": { "type": "PubMed", "id": "18077607", "url": "https://pubmed.ncbi.nlm.nih.gov/18077607" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P25098-1", "protein_name": "G protein-coupled receptor kinase 2", "gene_name": "GRK2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P25098", "url": "https://www.uniprot.org/uniprotkb/P25098" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "phosphorylation": [ { "start_pos": 685, "end_pos": 685, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P25098", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P25098" }, { "database": "PubMed", "id": "11278469", "url": 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"n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "EGF transregulates opioid receptors through EGFR-mediated GRK2 phosphorylation and activation.", "journal": "Molecular biology of the cell", "date": "2008", "authors": "Chen Y, Long H, Wu Z, Jiang X, Ma L", "reference": { "type": "PubMed", "id": "18463167", "url": "https://pubmed.ncbi.nlm.nih.gov/18463167" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P25098-1", "protein_name": "G protein-coupled receptor kinase 2", "gene_name": "GRK2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P25098", "url": "https://www.uniprot.org/uniprotkb/P25098" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "phosphorylation": [ { "start_pos": 13, "end_pos": 13, "kinase_uniprot_canonical_ac": "P00533-1", "kinase_gene_name": 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0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Role of the amino terminus of G protein-coupled receptor kinase 2 in receptor phosphorylation.", "journal": "Biochemistry", "date": "2009", "authors": "Pao CS, Barker BL, Benovic JL", "reference": { "type": "PubMed", "id": "19715378", "url": "https://pubmed.ncbi.nlm.nih.gov/19715378" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P25098-1", "protein_name": "G protein-coupled receptor kinase 2", "gene_name": "GRK2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P25098", "url": "https://www.uniprot.org/uniprotkb/P25098" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 10, "end_pos": 10, "sequence_org": "D", "sequence_mut": "A", "comment": "95% reduction in phosphorylation of G protein coupled receptor rhodopsin and beta-2 adrenergic receptor ADRB2. Does not affect binding to ADRB2. Not activated by receptor binding. No effect on phosphorylation of the non-receptor substrate tubulin.", "evidence": [ { "database": "UniProtKB", "id": "P25098", "url": "https://www.uniprot.org/uniprotkb/P25098" }, { "database": "PubMed", "id": "19715378", "url": "https://pubmed.ncbi.nlm.nih.gov/19715378" } ], "uniprot_canonical_ac": "P25098-1" }, { "start_pos": 3, "end_pos": 3, "sequence_org": "D", "sequence_mut": "A", "comment": "85% reduction in phosphorylation of G protein coupled receptor rhodopsin.", "evidence": [ { "database": "UniProtKB", "id": "P25098", "url": "https://www.uniprot.org/uniprotkb/P25098" }, { "database": "PubMed", "id": "19715378", "url": "https://pubmed.ncbi.nlm.nih.gov/19715378" } ], "uniprot_canonical_ac": "P25098-1" }, { "start_pos": 3, "end_pos": 3, "sequence_org": "D", "sequence_mut": "K", "comment": "95% reduction in phosphorylation of G protein coupled receptor rhodopsin. 60% reduction in phosphorylation of beta-2 adrenergic receptor ADRB2. Does not affect binding to ADRB2. Not activated by receptor binding. No effect on phosphorylation of the non-receptor substrate tubulin.", "evidence": [ { "database": "UniProtKB", "id": "P25098", "url": "https://www.uniprot.org/uniprotkb/P25098" }, { "database": "PubMed", "id": "19715378", "url": "https://pubmed.ncbi.nlm.nih.gov/19715378" } ], "uniprot_canonical_ac": "P25098-1" }, { "start_pos": 3, "end_pos": 3, "sequence_org": "D", "sequence_mut": "N", "comment": "60% reduction in phosphorylation of G protein coupled receptor rhodopsin.", "evidence": [ { "database": "UniProtKB", "id": "P25098", "url": "https://www.uniprot.org/uniprotkb/P25098" }, { "database": "PubMed", "id": "19715378", "url": "https://pubmed.ncbi.nlm.nih.gov/19715378" } ], "uniprot_canonical_ac": "P25098-1" }, { "start_pos": 4, "end_pos": 4, "sequence_org": "L", "sequence_mut": "A", "comment": "95% reduction in phosphorylation of G protein coupled receptor rhodopsin. 90% reduction in phosphorylation of beta-2 adrenergic receptor ADRB2. 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Raphael S, Free R Benjamin, Hoffman Carsten, Sibley David R", "reference": { "type": "PubMed", "id": "37892234", "url": "https://pubmed.ncbi.nlm.nih.gov/37892234" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P25098-1", "protein_name": "G protein-coupled receptor kinase 2", "gene_name": "GRK2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P25098", "url": "https://www.uniprot.org/uniprotkb/P25098" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.37892234", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", 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William, Ku Pei-I, Zhu Ju-Fen, Michaelson Zachary, Yen Yu-Chen, Lee Annabel, Long Alyssa B, Casey Mattie J, Poddar Abhishek, Nelson Isaac B, Arveseth Corvin D, Nagel Falko, Clough Ryan, LaPotin Sarah, Kwan Kristen M, Schulz Stefan, Stewart Rodney A, Tesmer John J G, Caspary Tamara, Subramanian Radhika, Ge Xuecai, Myers Benjamin R", "reference": { "type": "PubMed", "id": "39138140", "url": "https://pubmed.ncbi.nlm.nih.gov/39138140" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P25098-1", "protein_name": "G protein-coupled receptor kinase 2", "gene_name": "GRK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5RH73-1", "protein_name": "Protein smoothened", "gene_name": "smo", "tax_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q99MK8-1", "protein_name": "G protein-coupled receptor kinase 2", "gene_name": "Grk2", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q99835-1", "protein_name": "Protein smoothened", "gene_name": "SMO", "tax_name": 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