[ { "title": "ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability.", "journal": "Molecular and cellular biology", "date": "2004", "authors": "Lang V, Symons A, Watton SJ, Janzen J, Soneji Y, Beinke S, Howell S, Ley SC", "reference": { "type": "PubMed", "id": "15169888", "url": "https://pubmed.ncbi.nlm.nih.gov/15169888" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13616-1", "protein_name": "Cullin-1", "gene_name": "CUL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19838-1", "protein_name": "Nuclear factor NF-kappa-B p105 subunit", "gene_name": "NFKB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14920-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit beta", "gene_name": "IKBKB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P45985-1", "protein_name": "Dual specificity mitogen-activated protein kinase kinase 4", "gene_name": "MAP2K4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFZ5-1", "protein_name": "TNFAIP3-interacting protein 2", "gene_name": "TNIP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y297-1", "protein_name": "F-box/WD repeat-containing protein 1A", "gene_name": "BTRC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UKB1-1", "protein_name": "F-box/WD repeat-containing protein 11", "gene_name": "FBXW11", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q02750-1", "protein_name": "Dual specificity mitogen-activated protein kinase kinase 1", "gene_name": "MAP2K1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99JG7-1", "protein_name": "TNFAIP3-interacting protein 2", "gene_name": "Tnip2", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "P41279-1", "protein_name": "Mitogen-activated protein kinase kinase kinase 8", "gene_name": "MAP3K8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6K9-1", "protein_name": "NF-kappa-B essential modulator", "gene_name": "IKBKG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63208-1", "protein_name": "S-phase kinase-associated protein 1", "gene_name": "SKP1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15111", "url": "https://www.uniprot.org/uniprotkb/O15111" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.15169888", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 17 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2004", "authors": "Witherow D Scott, Garrison Tiffany Runyan, Miller William E, Lefkowitz Robert J", "reference": { "type": "PubMed", "id": "15173580", "url": "https://pubmed.ncbi.nlm.nih.gov/15173580" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14920-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit beta", "gene_name": "IKBKB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P29067-1", "protein_name": "Beta-arrestin-2", "gene_name": "Arrb2", "tax_name": "Rat" }, { "uniprot_canonical_ac": "P29066-1", "protein_name": "Beta-arrestin-1", "gene_name": "Arrb1", "tax_name": "Rat" }, { "uniprot_canonical_ac": "Q99558-1", "protein_name": "Mitogen-activated protein kinase kinase kinase 14", "gene_name": "MAP3K14", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15111", "url": "https://www.uniprot.org/uniprotkb/O15111" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.15173580", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 5 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Molecular analysis of the genetic defect in a large cohort of IP patients and identification of novel NEMO mutations interfering with NF-kappaB activation.", "journal": "Human molecular genetics", "date": "2004", "authors": "Fusco F, Bardaro T, Fimiani G, Mercadante V, Miano MG, Falco G, Israel A, Courtois G, D'Urso M, Ursini MV", "reference": { "type": "PubMed", "id": "15229184", "url": "https://pubmed.ncbi.nlm.nih.gov/15229184" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14920-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit beta", "gene_name": "IKBKB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6K9-1", "protein_name": "NF-kappa-B essential modulator", "gene_name": "IKBKG", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15111", "url": "https://www.uniprot.org/uniprotkb/O15111" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.15229184", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", 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"o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The same IkappaBalpha mutation in two related individuals leads to completely different clinical syndromes.", "journal": "The Journal of experimental medicine", "date": "2004", "authors": "Janssen R, van Wengen A, Hoeve MA, ten Dam M, van der Burg M, van Dongen J, van de Vosse E, van Tol M, Bredius R, Ottenhoff TH, Weemaes C, van Dissel JT, Lankester A", "reference": { "type": "PubMed", "id": "15337789", "url": "https://pubmed.ncbi.nlm.nih.gov/15337789" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Human" }, { "uniprot_canonical_ac": "P25963-1", "protein_name": "NF-kappa-B inhibitor alpha", "gene_name": "NFKBIA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19838-1", "protein_name": "Nuclear factor NF-kappa-B p105 subunit", "gene_name": "NFKB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14920-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit beta", "gene_name": "IKBKB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00653-1", "protein_name": "Nuclear factor NF-kappa-B p100 subunit", "gene_name": "NFKB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6K9-1", "protein_name": "NF-kappa-B essential modulator", "gene_name": "IKBKG", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04206-1", "protein_name": "Transcription factor p65", "gene_name": "RELA", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15111", "url": "https://www.uniprot.org/uniprotkb/O15111" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.15337789", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": 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Biol. Chem.", "date": "2004", "authors": "Bruey JM, Bruey-Sedano N, Newman R, Chandler S, Stehlik C, Reed JC", "reference": { "type": "PubMed", "id": "15456791", "url": "https://pubmed.ncbi.nlm.nih.gov/15456791" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9ULZ3-1", "protein_name": "Apoptosis-associated speck-like protein containing a CARD", "gene_name": "PYCARD", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14920-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit beta", "gene_name": "IKBKB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NX02-1", "protein_name": "NACHT, LRR and PYD domains-containing protein 2", "gene_name": "NLRP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6K9-1", "protein_name": "NF-kappa-B essential modulator", "gene_name": "IKBKG", 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the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2005", "authors": "Kaiser WJ, Offermann MK", "reference": { "type": "PubMed", "id": "15814722", "url": "https://pubmed.ncbi.nlm.nih.gov/15814722" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15750-1", "protein_name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 1", "gene_name": "TAB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43187-1", "protein_name": "Interleukin-1 receptor-associated kinase-like 2", "gene_name": "IRAK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13546-1", "protein_name": "Receptor-interacting serine/threonine-protein kinase 1", "gene_name": "RIPK1", "tax_name": 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"Ubiquitin-conjugating enzyme E2 D2", "gene_name": "UBE2D2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13489-1", "protein_name": "Baculoviral IAP repeat-containing protein 3", "gene_name": "BIRC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15455-1", "protein_name": "Toll-like receptor 3", "gene_name": "TLR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08571-1", "protein_name": "Monocyte differentiation antigen CD14", "gene_name": "CD14", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13404-4", "protein_name": "Ubiquitin-conjugating enzyme E2 variant 1", "gene_name": "UBE2V1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86XR7-1", "protein_name": "TIR domain-containing adapter molecule 2", "gene_name": "TICAM2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IUC6-1", "protein_name": "TIR domain-containing adapter molecule 1", "gene_name": "TICAM1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14763-1", "protein_name": "Tumor necrosis factor receptor superfamily member 10B", "gene_name": "TNFRSF10B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q12933-1", "protein_name": "TNF receptor-associated factor 2", "gene_name": "TRAF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6K9-1", "protein_name": "NF-kappa-B essential modulator", "gene_name": "IKBKG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15111", "url": "https://www.uniprot.org/uniprotkb/O15111" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.15814722", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 37 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Cusson-Hermance N, Khurana S, Lee TH, Fitzgerald KA, Kelliher MA", "reference": { "type": "PubMed", "id": "16115877", "url": "https://pubmed.ncbi.nlm.nih.gov/16115877" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Human" }, { "uniprot_canonical_ac": "P25963-1", "protein_name": "NF-kappa-B inhibitor alpha", "gene_name": "NFKBIA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13546-1", "protein_name": "Receptor-interacting serine/threonine-protein kinase 1", "gene_name": "RIPK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y4K3-1", "protein_name": "TNF receptor-associated factor 6", "gene_name": "TRAF6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19838-1", "protein_name": "Nuclear factor NF-kappa-B p105 subunit", "gene_name": "NFKB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14920-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit beta", "gene_name": "IKBKB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61077-1", "protein_name": "Ubiquitin-conjugating enzyme E2 D3", "gene_name": "UBE2D3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P51668-1", "protein_name": "Ubiquitin-conjugating enzyme E2 D1", "gene_name": "UBE2D1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62985-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Chicken" }, { "uniprot_canonical_ac": "Q91974-1", "protein_name": "NF-kappa-B inhibitor alpha", "gene_name": "NFKBIA", "tax_name": "Chicken" }, { "uniprot_canonical_ac": "Q9NYS0-1", "protein_name": "NF-kappa-B inhibitor-interacting Ras-like protein 1", "gene_name": "NKIRAS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00206-1", "protein_name": "Toll-like receptor 4", "gene_name": "TLR4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6Y9-1", "protein_name": "Lymphocyte antigen 96", "gene_name": "LY96", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NYR9-1", "protein_name": "NF-kappa-B inhibitor-interacting Ras-like protein 2", "gene_name": "NKIRAS2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00653-1", "protein_name": "Nuclear factor NF-kappa-B p100 subunit", "gene_name": "NFKB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q08211-1", "protein_name": "ATP-dependent RNA helicase A", "gene_name": "DHX9", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG62-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Chicken" }, { "uniprot_canonical_ac": "Q13490-1", "protein_name": "Baculoviral IAP repeat-containing protein 2", "gene_name": "BIRC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61088-1", "protein_name": "Ubiquitin-conjugating enzyme E2 N", "gene_name": "UBE2N", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y572-1", "protein_name": "Receptor-interacting serine/threonine-protein kinase 3", "gene_name": "RIPK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62837-1", "protein_name": "Ubiquitin-conjugating enzyme E2 D2", "gene_name": "UBE2D2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13489-1", "protein_name": "Baculoviral IAP repeat-containing protein 3", "gene_name": "BIRC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15455-1", "protein_name": "Toll-like receptor 3", "gene_name": "TLR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "E1C626-1", "protein_name": "TNF receptor-associated factor", "gene_name": "TRAF6", "tax_name": "Chicken" }, { "uniprot_canonical_ac": "P79781-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Chicken" }, { "uniprot_canonical_ac": "P98152-1", "protein_name": "Transcription factor p65", "gene_name": "RELA", "tax_name": "Chicken" }, { "uniprot_canonical_ac": "Q04861-1", "protein_name": "Nuclear factor NF-kappa-B p105 subunit", "gene_name": "NFKB1", "tax_name": "Chicken" }, { "uniprot_canonical_ac": "Q5ZJB4-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Chicken" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08571-1", "protein_name": "Monocyte differentiation antigen CD14", "gene_name": "CD14", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99836-1", "protein_name": "Myeloid differentiation primary response protein MyD88", "gene_name": "MYD88", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13404-4", "protein_name": "Ubiquitin-conjugating enzyme E2 variant 1", "gene_name": "UBE2V1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H171-1", "protein_name": "Z-DNA-binding protein 1", "gene_name": "ZBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86XR7-1", "protein_name": "TIR domain-containing adapter molecule 2", "gene_name": "TICAM2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15653-1", "protein_name": "NF-kappa-B inhibitor beta", "gene_name": "NFKBIB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IUC6-1", "protein_name": "TIR domain-containing adapter molecule 1", "gene_name": "TICAM1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6K9-1", "protein_name": "NF-kappa-B essential modulator", "gene_name": "IKBKG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04206-1", "protein_name": "Transcription factor p65", "gene_name": "RELA", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15111", "url": "https://www.uniprot.org/uniprotkb/O15111" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.16115877", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 41 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Blonska M, Shambharkar PB, Kobayashi M, Zhang D, Sakurai H, Su B, Lin X", "reference": { "type": "PubMed", "id": "16260783", "url": "https://pubmed.ncbi.nlm.nih.gov/16260783" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15750-1", "protein_name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 1", "gene_name": "TAB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P98170-1", "protein_name": "E3 ubiquitin-protein ligase XIAP", "gene_name": "XIAP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13546-1", "protein_name": "Receptor-interacting serine/threonine-protein kinase 1", "gene_name": "RIPK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P21580-1", "protein_name": "Tumor necrosis factor alpha-induced protein 3", "gene_name": "TNFAIP3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19438-1", "protein_name": "Tumor necrosis factor receptor superfamily member 1A", "gene_name": "TNFRSF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UM82-1", "protein_name": "Spermatogenesis-associated protein 2", "gene_name": "SPATA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BYM8-1", "protein_name": "RanBP-type and C3HC4-type zinc finger-containing protein 1", "gene_name": "RBCK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96EP0-1", "protein_name": "E3 ubiquitin-protein ligase RNF31", "gene_name": "RNF31", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H0F6-1", "protein_name": "Sharpin", "gene_name": "SHARPIN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VV17-1", "protein_name": "OTU domain-containing protein 1", "gene_name": "OTUD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14920-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit beta", "gene_name": "IKBKB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6GQQ9-1", "protein_name": "OTU domain-containing protein 7B", "gene_name": "OTUD7B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQC7-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase CYLD", "gene_name": "CYLD", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UK80-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 21", "gene_name": "USP21", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43318-1", "protein_name": "Mitogen-activated protein kinase kinase kinase 7", "gene_name": "MAP3K7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96CV9-1", "protein_name": "Optineurin", "gene_name": "OPTN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13077-1", "protein_name": "TNF receptor-associated factor 1", "gene_name": "TRAF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15628-1", "protein_name": "Tumor necrosis factor receptor type 1-associated DEATH domain protein", "gene_name": "TRADD", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N5C8-1", "protein_name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 3", "gene_name": "TAB3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13490-1", "protein_name": "Baculoviral IAP repeat-containing protein 2", "gene_name": "BIRC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NYJ8-1", "protein_name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2", "gene_name": "TAB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13489-1", "protein_name": "Baculoviral IAP repeat-containing protein 3", "gene_name": "BIRC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01375-1", "protein_name": "Tumor necrosis factor", "gene_name": "TNF", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q12933-1", "protein_name": "TNF receptor-associated factor 2", "gene_name": "TRAF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6K9-1", "protein_name": "NF-kappa-B essential modulator", "gene_name": "IKBKG", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13107-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 4", "gene_name": "USP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63244-1", "protein_name": "Small ribosomal subunit protein RACK1", "gene_name": "RACK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75604-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 2", "gene_name": "USP2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15111", "url": "https://www.uniprot.org/uniprotkb/O15111" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.16260783", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 33 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], 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"uniprot_canonical_ac": "Q92851-1", "protein_name": "Caspase-10", "gene_name": "CASP10", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13158-1", "protein_name": "FAS-associated death domain protein", "gene_name": "FADD", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95786-1", "protein_name": "Antiviral innate immune response receptor RIG-I", "gene_name": "DDX58; RIGI", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9C037-1", "protein_name": "E3 ubiquitin-protein ligase TRIM4", "gene_name": "TRIM4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7Z434-1", "protein_name": "Mitochondrial antiviral-signaling protein", "gene_name": "MAVS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14790-1", "protein_name": "Caspase-8", "gene_name": "CASP8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IUD6-1", "protein_name": "E3 ubiquitin-protein ligase RNF135", "gene_name": "RNF135", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BYX4-1", "protein_name": 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO.", "journal": "Molecular cell", "date": "2006", "authors": "Ea CK, Deng L, Xia ZP, Pineda G, Chen ZJ", "reference": { "type": "PubMed", "id": "16603398", "url": "https://pubmed.ncbi.nlm.nih.gov/16603398" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15750-1", "protein_name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 1", "gene_name": "TAB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P98170-1", "protein_name": "E3 ubiquitin-protein ligase XIAP", "gene_name": "XIAP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13546-1", "protein_name": "Receptor-interacting serine/threonine-protein kinase 1", "gene_name": "RIPK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y4K3-1", "protein_name": "TNF receptor-associated factor 6", "gene_name": "TRAF6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P21580-1", "protein_name": "Tumor necrosis factor alpha-induced protein 3", "gene_name": "TNFAIP3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19438-1", "protein_name": "Tumor necrosis factor receptor superfamily member 1A", "gene_name": "TNFRSF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UM82-1", "protein_name": "Spermatogenesis-associated protein 2", "gene_name": "SPATA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BYM8-1", "protein_name": "RanBP-type and C3HC4-type zinc finger-containing protein 1", "gene_name": "RBCK1", "tax_name": 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"protein_name": "Ubiquitin carboxyl-terminal hydrolase CYLD", "gene_name": "CYLD", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UK80-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 21", "gene_name": "USP21", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00206-1", "protein_name": "Toll-like receptor 4", "gene_name": "TLR4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6Y9-1", "protein_name": "Lymphocyte antigen 96", "gene_name": "LY96", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43318-1", "protein_name": "Mitogen-activated protein kinase kinase kinase 7", "gene_name": "MAP3K7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96CV9-1", "protein_name": "Optineurin", "gene_name": "OPTN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13077-1", "protein_name": "TNF receptor-associated factor 1", "gene_name": "TRAF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15628-1", "protein_name": "Tumor necrosis factor receptor type 1-associated 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"Human" }, { "uniprot_canonical_ac": "O75604-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 2", "gene_name": "USP2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15111", "url": "https://www.uniprot.org/uniprotkb/O15111" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 377, "end_pos": 377, "sequence_org": "K", "sequence_mut": "R", "comment": "Abolishes RIP-mediated NF-Kappa-B activation.", "evidence": [ { "database": "UniProtKB", "id": "Q13546", "url": "https://www.uniprot.org/uniprotkb/Q13546" }, { "database": "PubMed", "id": "16603398", "url": "https://pubmed.ncbi.nlm.nih.gov/16603398" } ], "uniprot_canonical_ac": "Q13546-1" } ], "record_id": "pubmed.16603398", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", 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"uniprot_canonical_ac": "Q9C037-1", "protein_name": "E3 ubiquitin-protein ligase TRIM4", "gene_name": "TRIM4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7Z434-1", "protein_name": "Mitochondrial antiviral-signaling protein", "gene_name": "MAVS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14790-1", "protein_name": "Caspase-8", "gene_name": "CASP8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IUD6-1", "protein_name": "E3 ubiquitin-protein ligase RNF135", "gene_name": "RNF135", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BYX4-1", "protein_name": "Interferon-induced helicase C domain-containing protein 1", "gene_name": "IFIH1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6K9-1", "protein_name": "NF-kappa-B essential modulator", "gene_name": "IKBKG", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15111", "url": "https://www.uniprot.org/uniprotkb/O15111" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.16618810", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 13 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", 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"glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Interleukin-1 stimulated activation of the COT catalytic subunit through the phosphorylation of Thr290 and Ser62.", "journal": "FEBS letters", "date": "2006", "authors": "Stafford MJ, Morrice NA, Peggie MW, Cohen P", "reference": { "type": "PubMed", "id": "16806191", "url": "https://pubmed.ncbi.nlm.nih.gov/16806191" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13616-1", "protein_name": "Cullin-1", "gene_name": "CUL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19838-1", "protein_name": "Nuclear factor NF-kappa-B p105 subunit", "gene_name": "NFKB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14920-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit beta", "gene_name": "IKBKB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P45985-1", "protein_name": "Dual specificity mitogen-activated protein kinase kinase 4", "gene_name": "MAP2K4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFZ5-1", "protein_name": "TNFAIP3-interacting protein 2", "gene_name": "TNIP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y297-1", "protein_name": "F-box/WD repeat-containing protein 1A", "gene_name": "BTRC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UKB1-1", "protein_name": "F-box/WD repeat-containing protein 11", "gene_name": "FBXW11", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q02750-1", "protein_name": "Dual specificity mitogen-activated protein kinase kinase 1", "gene_name": "MAP2K1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P41279-1", "protein_name": "Mitogen-activated protein kinase kinase kinase 8", "gene_name": "MAP3K8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6K9-1", "protein_name": "NF-kappa-B essential modulator", "gene_name": "IKBKG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63208-1", "protein_name": "S-phase kinase-associated protein 1", "gene_name": "SKP1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15111", "url": "https://www.uniprot.org/uniprotkb/O15111" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "phosphorylation": [ { "start_pos": 290, "end_pos": 290, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P41279", "url": "https://www.uniprot.org/uniprotkb/P41279" }, { "database": "PubMed", "id": "15699325", "url": "https://pubmed.ncbi.nlm.nih.gov/15699325" }, { "database": "PubMed", "id": "15466476", "url": "https://pubmed.ncbi.nlm.nih.gov/15466476" }, { "database": "PRO", "id": "P41279", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=P41279" }, { "database": "iPTMnet", "id": "P41279", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P41279" }, { "database": "PubMed", "id": "16806191", "url": "https://pubmed.ncbi.nlm.nih.gov/16806191" }, { "database": "PubMed", "id": "19754427", "url": "https://pubmed.ncbi.nlm.nih.gov/19754427" }, { "database": "PubMed", "id": "26456302", "url": "https://pubmed.ncbi.nlm.nih.gov/26456302" }, { "database": "PubMed", "id": "33488582", "url": "https://pubmed.ncbi.nlm.nih.gov/33488582" } ], "site_lbl": "Thr290", "uniprot_canonical_ac": "P41279-1" }, { "start_pos": 62, "end_pos": 62, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P41279", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P41279" }, { "database": "PubMed", "id": "16806191", "url": "https://pubmed.ncbi.nlm.nih.gov/16806191" }, { "database": "PubMed", "id": "19754427", "url": "https://pubmed.ncbi.nlm.nih.gov/19754427" } ], "site_lbl": "Ser62", "uniprot_canonical_ac": "P41279-1" } ], "record_id": "pubmed.16806191", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 16 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": 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"total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases.", "journal": "FEBS letters", "date": "2006", "authors": "Schauvliege R, Janssens S, Beyaert R", "reference": { "type": "PubMed", "id": "16884718", "url": "https://pubmed.ncbi.nlm.nih.gov/16884718" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y4K3-1", "protein_name": "TNF receptor-associated factor 6", "gene_name": "TRAF6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96FA3-1", "protein_name": "E3 ubiquitin-protein ligase pellino homolog 1", "gene_name": "PELI1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HAT8-1", "protein_name": "E3 ubiquitin-protein ligase pellino homolog 2", "gene_name": "PELI2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14920-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit beta", "gene_name": "IKBKB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61088-1", "protein_name": "Ubiquitin-conjugating enzyme E2 N", "gene_name": "UBE2N", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N2H9-1", "protein_name": "E3 ubiquitin-protein ligase pellino homolog 3", "gene_name": "PELI3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P51617-1", "protein_name": "Interleukin-1 receptor-associated kinase 1", "gene_name": "IRAK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13404-4", "protein_name": "Ubiquitin-conjugating enzyme E2 variant 1", "gene_name": "UBE2V1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6K9-1", "protein_name": "NF-kappa-B essential modulator", "gene_name": "IKBKG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15111", "url": "https://www.uniprot.org/uniprotkb/O15111" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.16884718", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 14 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma.", "journal": "Oncogene", "date": "2007", "authors": "Jackson-Bernitsas DG, Ichikawa H, Takada Y, Myers JN, Lin XL, Darnay BG, Chaturvedi MM, Aggarwal BB", "reference": { "type": "PubMed", "id": "16953224", "url": "https://pubmed.ncbi.nlm.nih.gov/16953224" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15750-1", "protein_name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 1", "gene_name": "TAB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P98170-1", "protein_name": "E3 ubiquitin-protein ligase XIAP", "gene_name": "XIAP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13546-1", "protein_name": "Receptor-interacting serine/threonine-protein kinase 1", "gene_name": "RIPK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P21580-1", "protein_name": "Tumor necrosis factor alpha-induced protein 3", "gene_name": "TNFAIP3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19438-1", "protein_name": "Tumor necrosis factor receptor superfamily member 1A", "gene_name": "TNFRSF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UM82-1", "protein_name": "Spermatogenesis-associated protein 2", "gene_name": "SPATA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BYM8-1", "protein_name": "RanBP-type and C3HC4-type zinc finger-containing protein 1", "gene_name": "RBCK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96EP0-1", "protein_name": "E3 ubiquitin-protein ligase RNF31", "gene_name": "RNF31", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H0F6-1", "protein_name": "Sharpin", "gene_name": "SHARPIN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VV17-1", "protein_name": "OTU domain-containing protein 1", "gene_name": "OTUD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14920-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit beta", "gene_name": "IKBKB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6GQQ9-1", "protein_name": "OTU domain-containing protein 7B", "gene_name": "OTUD7B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQC7-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase CYLD", "gene_name": "CYLD", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UK80-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 21", "gene_name": "USP21", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43318-1", "protein_name": "Mitogen-activated protein kinase kinase kinase 7", "gene_name": "MAP3K7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96CV9-1", "protein_name": "Optineurin", "gene_name": "OPTN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13077-1", "protein_name": "TNF receptor-associated factor 1", "gene_name": "TRAF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15628-1", "protein_name": "Tumor necrosis factor receptor type 1-associated DEATH domain protein", "gene_name": "TRADD", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N5C8-1", "protein_name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 3", "gene_name": "TAB3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13490-1", "protein_name": "Baculoviral IAP repeat-containing protein 2", "gene_name": "BIRC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NYJ8-1", "protein_name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2", "gene_name": "TAB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13489-1", "protein_name": "Baculoviral IAP repeat-containing protein 3", "gene_name": "BIRC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01375-1", "protein_name": "Tumor necrosis factor", "gene_name": "TNF", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q12933-1", "protein_name": "TNF receptor-associated factor 2", "gene_name": "TRAF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6K9-1", "protein_name": "NF-kappa-B essential modulator", "gene_name": "IKBKG", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13107-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 4", "gene_name": "USP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63244-1", "protein_name": "Small ribosomal subunit protein RACK1", "gene_name": "RACK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75604-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 2", "gene_name": "USP2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IkappaB kinase alpha pathway targeting activator protein-1.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Cahill CM, Rogers JT", "reference": { "type": "PubMed", "id": "18515365", "url": "https://pubmed.ncbi.nlm.nih.gov/18515365" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15111", "url": "https://www.uniprot.org/uniprotkb/O15111" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], 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"tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y4K3-1", "protein_name": "TNF receptor-associated factor 6", "gene_name": "TRAF6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96FA3-1", "protein_name": "E3 ubiquitin-protein ligase pellino homolog 1", "gene_name": "PELI1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HAT8-1", "protein_name": "E3 ubiquitin-protein ligase pellino homolog 2", "gene_name": "PELI2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14920-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit beta", "gene_name": "IKBKB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61088-1", "protein_name": "Ubiquitin-conjugating enzyme E2 N", "gene_name": "UBE2N", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N2H9-1", "protein_name": "E3 ubiquitin-protein ligase pellino homolog 3", "gene_name": "PELI3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P51617-1", "protein_name": "Interleukin-1 receptor-associated kinase 1", "gene_name": "IRAK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13404-4", "protein_name": "Ubiquitin-conjugating enzyme E2 variant 1", "gene_name": "UBE2V1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6K9-1", "protein_name": "NF-kappa-B essential modulator", "gene_name": "IKBKG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15111", "url": "https://www.uniprot.org/uniprotkb/O15111" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.18724939", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 14 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Non-apoptotic functions of caspase-8.", "journal": "Biochemical pharmacology", "date": "2008", "authors": "Maelfait J, Beyaert R", "reference": { "type": "PubMed", "id": "18761323", "url": "https://pubmed.ncbi.nlm.nih.gov/18761323" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13546-1", "protein_name": "Receptor-interacting serine/threonine-protein kinase 1", "gene_name": "RIPK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14920-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit beta", "gene_name": "IKBKB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14258-1", "protein_name": "E3 ubiquitin/ISG15 ligase TRIM25", "gene_name": "TRIM25", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92851-1", "protein_name": "Caspase-10", "gene_name": "CASP10", "tax_name": "Human" }, { "uniprot_canonical_ac": 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0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": 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"count": 0 } ], "sort_fields": [] } ] }, { "title": "The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling.", "journal": "Trends in immunology", "date": "2009", "authors": "Moynagh PN", "reference": { "type": "PubMed", "id": "19022706", "url": "https://pubmed.ncbi.nlm.nih.gov/19022706" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y4K3-1", "protein_name": "TNF receptor-associated factor 6", "gene_name": "TRAF6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96FA3-1", "protein_name": "E3 ubiquitin-protein ligase pellino homolog 1", "gene_name": "PELI1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HAT8-1", "protein_name": "E3 ubiquitin-protein ligase pellino homolog 2", "gene_name": "PELI2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14920-1", 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"n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction.", "journal": "Molecular cell", "date": "2009", "authors": "Haas TL, Emmerich CH, Gerlach B, Schmukle AC, Cordier SM, Rieser E, Feltham R, Vince J, Warnken U, Wenger T, Koschny R, Komander D, Silke J, Walczak H", "reference": { "type": "PubMed", "id": "20005846", "url": "https://pubmed.ncbi.nlm.nih.gov/20005846" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15750-1", "protein_name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 1", "gene_name": "TAB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P98170-1", "protein_name": "E3 ubiquitin-protein ligase XIAP", "gene_name": "XIAP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13546-1", "protein_name": "Receptor-interacting serine/threonine-protein kinase 1", "gene_name": "RIPK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P21580-1", "protein_name": "Tumor necrosis factor alpha-induced protein 3", "gene_name": "TNFAIP3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19438-1", "protein_name": "Tumor necrosis factor receptor superfamily member 1A", "gene_name": "TNFRSF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UM82-1", "protein_name": "Spermatogenesis-associated protein 2", "gene_name": "SPATA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BYM8-1", "protein_name": "RanBP-type and C3HC4-type zinc finger-containing protein 1", "gene_name": "RBCK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96EP0-1", "protein_name": "E3 ubiquitin-protein ligase RNF31", "gene_name": "RNF31", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H0F6-1", "protein_name": "Sharpin", "gene_name": "SHARPIN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VV17-1", "protein_name": "OTU domain-containing protein 1", "gene_name": "OTUD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14920-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit beta", "gene_name": "IKBKB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6GQQ9-1", "protein_name": "OTU domain-containing protein 7B", "gene_name": "OTUD7B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQC7-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase CYLD", "gene_name": "CYLD", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UK80-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 21", "gene_name": "USP21", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43318-1", "protein_name": "Mitogen-activated protein kinase kinase kinase 7", "gene_name": "MAP3K7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96CV9-1", "protein_name": "Optineurin", "gene_name": "OPTN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13077-1", "protein_name": "TNF receptor-associated factor 1", "gene_name": "TRAF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15628-1", "protein_name": "Tumor necrosis factor receptor type 1-associated DEATH domain protein", "gene_name": "TRADD", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N5C8-1", "protein_name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 3", "gene_name": "TAB3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13490-1", "protein_name": "Baculoviral IAP repeat-containing protein 2", "gene_name": "BIRC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NYJ8-1", "protein_name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2", "gene_name": "TAB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13489-1", "protein_name": "Baculoviral IAP repeat-containing protein 3", "gene_name": "BIRC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01375-1", "protein_name": "Tumor necrosis factor", "gene_name": "TNF", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q12933-1", "protein_name": "TNF receptor-associated factor 2", "gene_name": "TRAF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6K9-1", "protein_name": "NF-kappa-B essential modulator", "gene_name": "IKBKG", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13107-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 4", "gene_name": "USP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63244-1", "protein_name": "Small ribosomal subunit protein RACK1", "gene_name": "RACK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75604-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 2", "gene_name": "USP2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15111", "url": "https://www.uniprot.org/uniprotkb/O15111" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.20005846", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 33 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation.", "journal": "Science signaling", "date": "2010", "authors": "Razani B, Zarnegar B, Ytterberg AJ, Shiba T, Dempsey PW, Ware CF, Loo JA, Cheng G", "reference": { "type": "PubMed", "id": "20501937", "url": "https://pubmed.ncbi.nlm.nih.gov/20501937" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99558-1", "protein_name": "Mitogen-activated protein kinase kinase kinase 14", "gene_name": "MAP3K14", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15111", "url": "https://www.uniprot.org/uniprotkb/O15111" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "phosphorylation": [ { "start_pos": 559, "end_pos": 559, "kinase_uniprot_canonical_ac": "O15111-1", "kinase_gene_name": "CHUK", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q99558", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q99558" }, { "database": "PubMed", "id": "20501937", "url": "https://pubmed.ncbi.nlm.nih.gov/20501937" } ], "site_lbl": "Thr559", "uniprot_canonical_ac": "Q99558-1" } ], "record_id": "pubmed.20501937", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl", "uniprot_canonical_ac" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2010", "authors": "Kim T, Pazhoor S, Bao M, Zhang Z, Hanabuchi S, Facchinetti V, Bover L, Plumas J, Chaperot L, Qin J, Liu YJ", "reference": { "type": "PubMed", "id": "20696886", "url": "https://pubmed.ncbi.nlm.nih.gov/20696886" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Human" }, { "uniprot_canonical_ac": "P25963-1", "protein_name": "NF-kappa-B inhibitor alpha", "gene_name": "NFKBIA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13546-1", "protein_name": "Receptor-interacting serine/threonine-protein kinase 1", "gene_name": "RIPK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19838-1", "protein_name": "Nuclear factor NF-kappa-B p105 subunit", "gene_name": "NFKB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14920-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit beta", "gene_name": "IKBKB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H2U1-1", "protein_name": "ATP-dependent DNA/RNA helicase DHX36", "gene_name": "DHX36", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NYS0-1", "protein_name": "NF-kappa-B inhibitor-interacting Ras-like protein 1", "gene_name": "NKIRAS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NYR9-1", "protein_name": "NF-kappa-B inhibitor-interacting Ras-like protein 2", "gene_name": "NKIRAS2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00653-1", "protein_name": "Nuclear factor NF-kappa-B p100 subunit", "gene_name": "NFKB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92985-1", "protein_name": "Interferon regulatory factor 7", "gene_name": "IRF7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q08211-1", "protein_name": "ATP-dependent RNA helicase A", "gene_name": "DHX9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y572-1", "protein_name": "Receptor-interacting serine/threonine-protein kinase 3", "gene_name": "RIPK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15455-1", "protein_name": "Toll-like receptor 3", "gene_name": "TLR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99836-1", "protein_name": "Myeloid differentiation primary response protein MyD88", "gene_name": "MYD88", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H171-1", "protein_name": "Z-DNA-binding protein 1", "gene_name": "ZBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15653-1", "protein_name": "NF-kappa-B inhibitor beta", "gene_name": "NFKBIB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IUC6-1", "protein_name": "TIR domain-containing adapter molecule 1", "gene_name": "TICAM1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6K9-1", "protein_name": "NF-kappa-B essential modulator", "gene_name": "IKBKG", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04206-1", "protein_name": "Transcription factor p65", "gene_name": "RELA", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15111", "url": "https://www.uniprot.org/uniprotkb/O15111" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.20696886", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 19 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", 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Natl. Acad. Sci. U.S.A.", "date": "2010", "authors": "Gouin Edith, Adib-Conquy Minou, Balestrino Damien, Nahori Marie-Anne, Villiers V\u00e9ronique, Colland Fr\u00e9d\u00e9ric, Dramsi Shaynoor, Dussurget Olivier, Cossart Pascale", "reference": { "type": "PubMed", "id": "20855622", "url": "https://pubmed.ncbi.nlm.nih.gov/20855622" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04206-1", "protein_name": "Transcription factor p65", "gene_name": "RELA", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15111", "url": "https://www.uniprot.org/uniprotkb/O15111" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.20855622", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Mutant CHUK and severe fetal encasement malformation.", "journal": "N. 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Med.", "date": "2010", "authors": "Lahtela Jenni, Nousiainen Heidi O, Stefanovic Vedran, Tallila Jonna, Viskari Heli, Karikoski Riitta, Gentile Massimiliano, Saloranta Carola, Varilo Teppo, Salonen Riitta, Kestil\u00e4 Marjo", "reference": { "type": "PubMed", "id": "20961246", "url": "https://pubmed.ncbi.nlm.nih.gov/20961246" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15111", "url": "https://www.uniprot.org/uniprotkb/O15111" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.20961246", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", 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by targeting TAK1 and NEMO for deubiquitination through distinct mechanisms.", "journal": "Scientific reports", "date": "2015", "authors": "Yang Z, Xian H, Hu J, Tian S, Qin Y, Wang RF, Cui J", "reference": { "type": "PubMed", "id": "26240016", "url": "https://pubmed.ncbi.nlm.nih.gov/26240016" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y4K3-1", "protein_name": "TNF receptor-associated factor 6", "gene_name": "TRAF6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14920-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit beta", "gene_name": "IKBKB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86WI3-1", "protein_name": "Protein NLRC5", "gene_name": "NLRC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P54578-1", "protein_name": "Ubiquitin carboxyl-terminal 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"total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "IFIT5 positively regulates NF-kappaB signaling through synergizing the recruitment of IkappaB kinase (IKK) to TGF-beta-activated kinase 1 (TAK1).", "journal": "Cell. Signal.", "date": "2015", "authors": "Zheng C, Zheng Z, Zhang Z, Meng J, Liu Y, Ke X, Hu Q, Wang H", "reference": { "type": "PubMed", "id": "26334375", "url": "https://pubmed.ncbi.nlm.nih.gov/26334375" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14920-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit beta", "gene_name": "IKBKB", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43318-1", "protein_name": "Mitogen-activated protein kinase kinase kinase 7", "gene_name": "MAP3K7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13325-1", "protein_name": "Interferon-induced protein with tetratricopeptide repeats 5", "gene_name": "IFIT5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6K9-1", "protein_name": "NF-kappa-B essential modulator", "gene_name": "IKBKG", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15111", "url": "https://www.uniprot.org/uniprotkb/O15111" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.26334375", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 5 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Reversible ubiquitination shapes NLRC5 function and modulates NF-kappaB activation switch.", "journal": "The Journal of cell biology", "date": "2015", "authors": "Meng Q, Cai C, Sun T, Wang Q, Xie W, Wang R, Cui J", "reference": { "type": "PubMed", "id": "26620909", "url": "https://pubmed.ncbi.nlm.nih.gov/26620909" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y4K3-1", "protein_name": "TNF receptor-associated factor 6", "gene_name": "TRAF6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14920-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit beta", "gene_name": "IKBKB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86WI3-1", "protein_name": "Protein NLRC5", "gene_name": "NLRC5", "tax_name": 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} ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": 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"count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl", "uniprot_canonical_ac" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "DDX3 directly facilitates IKKalpha activation and regulates downstream signalling pathways.", "journal": "Biochem. J.", "date": "2018", "authors": "Fullam A, Gu L, Hohn Y, Schroder M", "reference": { "type": "PubMed", "id": "30341167", "url": "https://pubmed.ncbi.nlm.nih.gov/30341167" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00571-1", "protein_name": "ATP-dependent RNA helicase DDX3X", "gene_name": "DDX3X", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99558-1", "protein_name": "Mitogen-activated protein kinase kinase kinase 14", "gene_name": "MAP3K14", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15111", "url": "https://www.uniprot.org/uniprotkb/O15111" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.30341167", "abstract": "", "glycosylation": 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"count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "TRIM56 positively regulates TNF\u03b1-induced NF-\u03baB signaling by enhancing the ubiquitination of TAK1.", "journal": "International journal of biological macromolecules", "date": "2022-10-31", "authors": "Liu Yuchun, Chen Yang, Ding Cong, Zhu Xiangzhan, Song Xiaorui, Ren Yanhong, Wang Qionglin, Zhang Yaodong, Sun Xiaomin", "reference": { "type": "PubMed", "id": "35952808", "url": "https://pubmed.ncbi.nlm.nih.gov/35952808" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BRZ2-1", "protein_name": "E3 ubiquitin-protein ligase TRIM56", "gene_name": "TRIM56", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15111", "url": "https://www.uniprot.org/uniprotkb/O15111" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.35952808", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", 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"IL-1\u03b2 stimulates a novel, IKK\u03b1 -dependent, NIK -independent activation of non-canonical NF\u03baB signalling.", "journal": "Cellular signalling", "date": "2023-04-18", "authors": "McIntosh Kathryn, Khalaf Yousif H, Craig Rachel, West Christopher, McCulloch Ashley, Waghmare Ajay, Lawson Christopher, Chan Edmond Y W, Mackay Simon, Paul Andrew, Plevin Robin", "reference": { "type": "PubMed", "id": "37080443", "url": "https://pubmed.ncbi.nlm.nih.gov/37080443" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15111", "url": "https://www.uniprot.org/uniprotkb/O15111" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.37080443", "abstract": "", 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"n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The host antiviral protein SAMHD1 suppresses NF-\u03baB activation by interacting with the IKK complex during inflammatory responses and viral infection.", "journal": "The Journal of biological chemistry", "date": "2023-06", "authors": "Yang Hua, Espada Constanza E, Phillips Stacia, Martinez Nicholas, Kenney Adam D, Yount Jacob S, Xiong Yong, Wu Li", "reference": { "type": "PubMed", "id": "37100289", "url": "https://pubmed.ncbi.nlm.nih.gov/37100289" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15111", "url": "https://www.uniprot.org/uniprotkb/O15111" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.37100289", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", 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{ "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling.", "journal": "Nature communications", "date": "2023-10-20", "authors": "Chen Xudong, Xie Min, Zhang Sensen, Mongui\u00f3-Tortajada Marta, Yin Jian, Liu Chang, Zhang Youqi, Delacr\u00e9taz Maeva, Song Mingyue, Wang Yixue, Dong Lin, Ding Qiang, Zhou Boda, Tian Xiaolin, Deng Haiteng, Xu Lina, Liu Xiaohui, Yang Zi, Chang Qing, Na Jie, Zeng Wenwen, Superti-Furga Giulio, Rebsamen Manuele, Yang Maojun", "reference": { "type": "PubMed", "id": "37863913", "url": "https://pubmed.ncbi.nlm.nih.gov/37863913" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14920-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit beta", "gene_name": "IKBKB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13568-1", "protein_name": "Interferon regulatory factor 5", "gene_name": "IRF5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HAI6-1", "protein_name": "TLR adapter interacting with SLC15A4 on the lysosome", "gene_name": "TASL", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N697-1", "protein_name": "Solute carrier family 15 member 4", "gene_name": "SLC15A4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6K9-1", "protein_name": "NF-kappa-B essential modulator", "gene_name": "IKBKG", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15111", "url": "https://www.uniprot.org/uniprotkb/O15111" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.37863913", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 6 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Cytokines-activated nuclear IKK\u03b1-FAT10 pathway induces breast cancer tamoxifen-resistance.", "journal": "Science China. 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], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "IKAP is a scaffold protein of the IkappaB kinase complex.", "journal": "Nature", "date": "1998", "authors": "Cohen L, Henzel WJ, Baeuerle PA", "reference": { "type": "PubMed", "id": "9751059", "url": "https://pubmed.ncbi.nlm.nih.gov/9751059" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Human" }, { "uniprot_canonical_ac": "P25963-1", "protein_name": "NF-kappa-B inhibitor alpha", "gene_name": "NFKBIA", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14920-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit beta", "gene_name": "IKBKB", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95163-1", "protein_name": "Elongator complex protein 1", "gene_name": "ELP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04206-1", "protein_name": "Transcription factor p65", "gene_name": "RELA", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15111", "url": "https://www.uniprot.org/uniprotkb/O15111" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.9751059", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 5 } ], 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"count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes.", "journal": "Gene", "date": "1998", "authors": "Hu MC, Wang Y", "reference": { "type": "PubMed", "id": "9813230", "url": "https://pubmed.ncbi.nlm.nih.gov/9813230" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit 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"field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase.", "journal": "Mol. Cell. Biol.", "date": "1998", "authors": "Nemoto S, DiDonato JA, Lin A", "reference": { "type": "PubMed", "id": "9819420", "url": "https://pubmed.ncbi.nlm.nih.gov/9819420" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q60680-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "Chuk", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "O88351-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit beta", "gene_name": "Ikbkb", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "O14920-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit beta", "gene_name": "IKBKB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9QY78-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit beta", "gene_name": "Ikbkb", "tax_name": "Rat" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15111", "url": "https://www.uniprot.org/uniprotkb/O15111" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "phosphorylation": [ { "start_pos": 176, "end_pos": 176, "kinase_uniprot_canonical_ac": "Q99558-1", "kinase_gene_name": "MAP3K14", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O15111", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15111" }, { "database": "PubMed", "id": "16286467", "url": "https://pubmed.ncbi.nlm.nih.gov/16286467" }, { "database": "PubMed", "id": "9520446", "url": "https://pubmed.ncbi.nlm.nih.gov/9520446" }, { "database": "PubMed", "id": "9819420", "url": "https://pubmed.ncbi.nlm.nih.gov/9819420" } ], "site_lbl": "Ser176", "uniprot_canonical_ac": "O15111-1" }, { "start_pos": 180, "end_pos": 180, "kinase_uniprot_canonical_ac": "Q99558-1", "kinase_gene_name": "MAP3K14", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O15111", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15111" }, { "database": "PubMed", "id": "16286467", "url": "https://pubmed.ncbi.nlm.nih.gov/16286467" }, { "database": "PubMed", "id": "9819420", "url": "https://pubmed.ncbi.nlm.nih.gov/9819420" }, { "database": "PubMed", "id": "9520446", "url": "https://pubmed.ncbi.nlm.nih.gov/9520446" } ], "site_lbl": "Ser180", "uniprot_canonical_ac": "O15111-1" } ], "record_id": "pubmed.9819420", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 5 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl", "uniprot_canonical_ac" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105.", "journal": "Nature", "date": "1999", "authors": "Belich MP, Salmeron A, Johnston LH, Ley SC", "reference": { "type": "PubMed", "id": "9950430", "url": "https://pubmed.ncbi.nlm.nih.gov/9950430" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O15111-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13616-1", "protein_name": "Cullin-1", "gene_name": "CUL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19838-1", "protein_name": "Nuclear factor NF-kappa-B p105 subunit", "gene_name": "NFKB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q63562-1", "protein_name": "Mitogen-activated protein kinase kinase kinase 8", "gene_name": "Map3k8", "tax_name": "Rat" }, { "uniprot_canonical_ac": "O14920-1", "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit beta", "gene_name": "IKBKB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P45985-1", "protein_name": "Dual specificity mitogen-activated protein kinase kinase 4", "gene_name": "MAP2K4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFZ5-1", "protein_name": "TNFAIP3-interacting protein 2", "gene_name": "TNIP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y297-1", "protein_name": "F-box/WD repeat-containing protein 1A", "gene_name": "BTRC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UKB1-1", "protein_name": "F-box/WD repeat-containing protein 11", "gene_name": "FBXW11", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q02750-1", "protein_name": "Dual specificity mitogen-activated protein kinase kinase 1", "gene_name": "MAP2K1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P41279-1", "protein_name": "Mitogen-activated protein kinase kinase kinase 8", "gene_name": "MAP3K8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6K9-1", "protein_name": "NF-kappa-B essential modulator", "gene_name": "IKBKG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63208-1", "protein_name": "S-phase kinase-associated protein 1", "gene_name": "SKP1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15111", "url": "https://www.uniprot.org/uniprotkb/O15111" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.9950430", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 17 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", 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Sciences of the United States of America", "date": "2007-12-18", "authors": "Weiske J\u00f6rg, Albring Kai Frederik, Huber Otmar", "reference": { "type": "PubMed", "id": "18077326", "url": "https://pubmed.ncbi.nlm.nih.gov/18077326" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P49789-1", "protein_name": "Bis(5'-adenosyl)-triphosphatase", "gene_name": "FHIT", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35222-1", "protein_name": "Catenin beta-1", "gene_name": "CTNNB1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P49789", "url": "https://www.uniprot.org/uniprotkb/P49789" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.18077326", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", 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"Bioscience reports", "date": "2015-06-25", "authors": "Wojdy\u0142a-Mamo\u0144 Anna M, Guranowski Andrzej", "reference": { "type": "PubMed", "id": "26181368", "url": "https://pubmed.ncbi.nlm.nih.gov/26181368" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P49789-1", "protein_name": "Bis(5'-adenosyl)-triphosphatase", "gene_name": "FHIT", "tax_name": "Human" }, { "uniprot_canonical_ac": "F4KEV7-1", "protein_name": "Bifunctional bis(5'-adenosyl)-triphosphatase/adenylylsulfatase FHIT", "gene_name": "FHIT", "tax_name": "Mouse-ear cress" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P49789", "url": "https://www.uniprot.org/uniprotkb/P49789" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.26181368", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { 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"count": 0 } ], "sort_fields": [] } ] }, { "title": "Integrated analysis of FHIT gene alterations in cancer.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2024-01-18", "authors": "Sim\u00f3n-Carrasco Luc\u00eda, Pietrini Elena, L\u00f3pez-Contreras Andr\u00e9s J", "reference": { "type": "PubMed", "id": "38234243", "url": "https://pubmed.ncbi.nlm.nih.gov/38234243" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P49789-1", "protein_name": "Bis(5'-adenosyl)-triphosphatase", "gene_name": "FHIT", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P49789", "url": "https://www.uniprot.org/uniprotkb/P49789" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.38234243", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", 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