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Cell Biol.", "date": "1996", "authors": "Charnock-Jones D S, Day K, Smith S K", "reference": { "type": "PubMed", "id": "8624847", "url": "https://pubmed.ncbi.nlm.nih.gov/8624847" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P30101-1", "protein_name": "Protein disulfide-isomerase A3", "gene_name": "PDIA3", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P30101", "url": "https://www.uniprot.org/uniprotkb/P30101" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.8624847", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "ERp60 does not substitute for protein disulphide isomerase as the beta-subunit of prolyl 4-hydroxylase.", "journal": "Biochem. J.", "date": "1996", "authors": "Koivunen P, Helaakoski T, Annunen P, Veijola J, R\u00e4is\u00e4nen S, Pihlajaniemi T, Kivirikko K I", "reference": { "type": "PubMed", "id": "8687406", "url": "https://pubmed.ncbi.nlm.nih.gov/8687406" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P30101-1", "protein_name": "Protein disulfide-isomerase A3", "gene_name": "PDIA3", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P30101", "url": "https://www.uniprot.org/uniprotkb/P30101" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.8687406", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", 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"count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation.", "journal": "Molecular and cellular biology", "date": "2005", "authors": "Bossis G, Malnou CE, Farras R, Andermarcher E, Hipskind R, Rodriguez M, Schmidt D, Muller S, Jariel-Encontre I, Piechaczyk M", "reference": { "type": "PubMed", "id": "16055710", "url": "https://pubmed.ncbi.nlm.nih.gov/16055710" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P01100-1", "protein_name": "Protein c-Fos", "gene_name": "FOS", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P01100", "url": 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levels.", "evidence": [ { "database": "UniProtKB", "id": "P01100", "url": "https://www.uniprot.org/uniprotkb/P01100" }, { "database": "PubMed", "id": "16055710", "url": "https://pubmed.ncbi.nlm.nih.gov/16055710" } ], "uniprot_canonical_ac": "P01100-1" }, { "start_pos": 265, "end_pos": 265, "sequence_org": "K", "sequence_mut": "R", "comment": "Abolishes sumoylation. No change in nuclear location nor on protein stability. 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Localizes to the endoplasmic reticulum in quiescent cells. Activates phospholipid synthesis in growing cells.", "evidence": [ { "database": "UniProtKB", "id": "P01100", "url": "https://www.uniprot.org/uniprotkb/P01100" }, { "database": "PubMed", "id": "22105363", "url": "https://pubmed.ncbi.nlm.nih.gov/22105363" }, { "database": "PubMed", "id": "17160021", "url": "https://pubmed.ncbi.nlm.nih.gov/17160021" } ], "uniprot_canonical_ac": "P01100-1" }, { "start_pos": 30, "end_pos": 30, "sequence_org": "Y", "sequence_mut": "E", "comment": "Loss of activation of phospholipid synthesis; when associated with E-10.", "evidence": [ { "database": "UniProtKB", "id": "P01100", "url": "https://www.uniprot.org/uniprotkb/P01100" }, { "database": "PubMed", "id": "22105363", "url": "https://pubmed.ncbi.nlm.nih.gov/22105363" }, { "database": "PubMed", "id": "17160021", "url": "https://pubmed.ncbi.nlm.nih.gov/17160021" } ], "uniprot_canonical_ac": "P01100-1" }, { "start_pos": 30, "end_pos": 30, "sequence_org": "Y", "sequence_mut": "F", "comment": "Overall loss of Tyr-phosphorylation, including that of Y-10 phosphorylation. 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of America", "date": "2002", "authors": "Moehlmann T, Winkler E, Xia X, Edbauer D, Murrell J, Capell A, Kaether C, Zheng H, Ghetti B, Haass C, Steiner H", "reference": { "type": "PubMed", "id": "12048239", "url": "https://pubmed.ncbi.nlm.nih.gov/12048239" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P49768-1", "protein_name": "Presenilin-1", "gene_name": "PSEN1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P49768", "url": "https://www.uniprot.org/uniprotkb/P49768" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.12048239", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", 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No detectable amyloid-beta.", "evidence": [ { "database": "UniProtKB", "id": "P49768", "url": "https://www.uniprot.org/uniprotkb/P49768" }, { "database": "PubMed", "id": "16305624", "url": "https://pubmed.ncbi.nlm.nih.gov/16305624" }, { "database": "PubMed", "id": "20460383", "url": "https://pubmed.ncbi.nlm.nih.gov/20460383" } ], "uniprot_canonical_ac": "P49768-1" }, { "start_pos": 433, "end_pos": 433, "sequence_org": "P", "sequence_mut": "G", "comment": "Very little endoproteolysis. Little APP processing. No NOTCH1 processing. 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No effect on APP nor NOTCH1 processing. Reduced amyloid-beta protein 42/40 ratio.", "evidence": [ { "database": "UniProtKB", "id": "P49768", "url": "https://www.uniprot.org/uniprotkb/P49768" }, { "database": "PubMed", "id": "16305624", "url": "https://pubmed.ncbi.nlm.nih.gov/16305624" } ], "uniprot_canonical_ac": "P49768-1" }, { "start_pos": 434, "end_pos": 434, "sequence_org": "A", "sequence_mut": "I", "comment": "No endoproteolytic cleavage. No APP nor NOTCH1 processing. No detectable amyloid-beta.", "evidence": [ { "database": "UniProtKB", "id": "P49768", "url": "https://www.uniprot.org/uniprotkb/P49768" }, { "database": "PubMed", "id": "16305624", "url": "https://pubmed.ncbi.nlm.nih.gov/16305624" } ], "uniprot_canonical_ac": "P49768-1" }, { "start_pos": 434, "end_pos": 434, "sequence_org": "A", "sequence_mut": "L", "comment": "No endoproteolytic cleavage. No APP nor NOTCH1 processing. No detectable amyloid-beta.", "evidence": [ { "database": "UniProtKB", "id": "P49768", "url": "https://www.uniprot.org/uniprotkb/P49768" }, { "database": "PubMed", "id": "16305624", "url": "https://pubmed.ncbi.nlm.nih.gov/16305624" } ], "uniprot_canonical_ac": "P49768-1" }, { "start_pos": 434, "end_pos": 434, "sequence_org": "A", "sequence_mut": "V", "comment": "No endoproteolytic cleavage. No APP nor NOTCH1 processing. No detectable amyloid-beta.", "evidence": [ { "database": "UniProtKB", "id": "P49768", "url": "https://www.uniprot.org/uniprotkb/P49768" }, { "database": "PubMed", "id": "16305624", "url": "https://pubmed.ncbi.nlm.nih.gov/16305624" } ], "uniprot_canonical_ac": "P49768-1" }, { "start_pos": 435, "end_pos": 435, "sequence_org": "L", "sequence_mut": "A", "comment": "No effect on endoproteolytic cleavage. No effect on APP processing. Impaired NOTCH1 processing. 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"count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Chinese Presenilin-1 V97L mutation enhanced Abeta42 levels in SH-SY5Y neuroblastoma cells.", "journal": "Neuroscience letters", "date": "2006", "authors": "Fang B, Jia L, Jia J", "reference": { "type": "PubMed", "id": "16916581", "url": "https://pubmed.ncbi.nlm.nih.gov/16916581" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P49768-1", "protein_name": "Presenilin-1", "gene_name": "PSEN1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P49768", "url": "https://www.uniprot.org/uniprotkb/P49768" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.16916581", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", 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0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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Traykov L, Mehrabian S, Van den Broeck M, Radoslavova Raycheva M, Cruts M, Kirilova Jordanova A, Van Broeckhoven C", "reference": { "type": "PubMed", "id": "19797784", "url": "https://pubmed.ncbi.nlm.nih.gov/19797784" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P49768-1", "protein_name": "Presenilin-1", "gene_name": "PSEN1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P49768", "url": "https://www.uniprot.org/uniprotkb/P49768" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.19797784", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": 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No detectable amyloid-beta.", "evidence": [ { "database": "UniProtKB", "id": "P49768", "url": "https://www.uniprot.org/uniprotkb/P49768" }, { "database": "PubMed", "id": "16305624", "url": "https://pubmed.ncbi.nlm.nih.gov/16305624" }, { "database": "PubMed", "id": "20460383", "url": "https://pubmed.ncbi.nlm.nih.gov/20460383" } ], "uniprot_canonical_ac": "P49768-1" }, { "start_pos": 433, "end_pos": 433, "sequence_org": "P", "sequence_mut": "V", "comment": "No endoproteolytic cleavage; no APP, nor NOTCH1 processing. No detectable amyloid-beta.", "evidence": [ { "database": "UniProtKB", "id": "P49768", "url": "https://www.uniprot.org/uniprotkb/P49768" }, { "database": "PubMed", "id": "16305624", "url": "https://pubmed.ncbi.nlm.nih.gov/16305624" }, { "database": "PubMed", "id": "20460383", "url": "https://pubmed.ncbi.nlm.nih.gov/20460383" } ], "uniprot_canonical_ac": "P49768-1" }, { "start_pos": 435, "end_pos": 435, "sequence_org": "L", "sequence_mut": "R", "comment": "No endoproteolytic cleavage; no APP, nor NOTCH1 processing. No detectable amyloid-beta.", "evidence": [ { "database": "UniProtKB", "id": "P49768", "url": "https://www.uniprot.org/uniprotkb/P49768" }, { "database": "PubMed", "id": "20460383", "url": "https://pubmed.ncbi.nlm.nih.gov/20460383" } ], "uniprot_canonical_ac": "P49768-1" } ], "record_id": "pubmed.20460383", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation.", "journal": "Traffic", "date": "2011", "authors": "Viswanathan Jayashree, Haapasalo Annakaisa, B\u00f6ttcher Claudia, Miettinen Riitta, Kurkinen Kaisa M A, Lu Alice, Thomas Anne, Maynard Christa J, Romano Donna, Hyman Bradley T, Berezovska Oksana, Bertram Lars, Soininen Hilkka, Dantuma Nico P, Tanzi Rudolph E, Hiltunen Mikko", "reference": { "type": "PubMed", "id": "21143716", "url": "https://pubmed.ncbi.nlm.nih.gov/21143716" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P49768-1", "protein_name": "Presenilin-1", "gene_name": "PSEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UMX0-1", "protein_name": "Ubiquilin-1", "gene_name": "UBQLN1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P49768", "url": "https://www.uniprot.org/uniprotkb/P49768" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.21143716", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], 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