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syndrome.", "journal": "European heart journal", "date": "2019", "authors": "Belbachir N, Portero V, Al Sayed ZR, Gourraud JB, Dilasser F, Jesel L, Guo H, Wu H, Gaborit N, Guilluy C, Girardeau A, Bonnaud S, Simonet F, Karakachoff M, Pattier S, Scott C, Burel S, Marionneau C, Chariau C, Gaignerie A, David L, Genin E, Deleuze JF, Dina C, Sauzeau V, Loirand G, Baro I, Schott JJ, Probst V, Wu JC, Redon R, Charpentier F, Le Scouarnec S", "reference": { "type": "PubMed", "id": "31114854", "url": "https://pubmed.ncbi.nlm.nih.gov/31114854" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P55042-1", "protein_name": "GTP-binding protein RAD", "gene_name": "RRAD", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P55042", "url": "https://www.uniprot.org/uniprotkb/P55042" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": 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Complete cDNA sequence of the BF*S allele.", "journal": "Human immunology", "date": "1994", "authors": "Mejia JE, Jahn I, de la Salle H, Hauptmann G", "reference": { "type": "PubMed", "id": "8181962", "url": "https://pubmed.ncbi.nlm.nih.gov/8181962" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P00751-1", "protein_name": "Complement factor B", "gene_name": "CFB", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P00751", "url": "https://www.uniprot.org/uniprotkb/P00751" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.8181962", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", 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MB, Le Beau MM, Rosner MR", "reference": { "type": "PubMed", "id": "11875070", "url": "https://pubmed.ncbi.nlm.nih.gov/11875070" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8TD08-1", "protein_name": "Mitogen-activated protein kinase 15", "gene_name": "MAPK15", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Z2A6-1", "protein_name": "Mitogen-activated protein kinase 15", "gene_name": "Mapk15", "tax_name": "Rat" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8TD08", "url": "https://www.uniprot.org/uniprotkb/Q8TD08" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 175, "end_pos": 175, "sequence_org": "T", "sequence_mut": "A", "comment": "Loss of autophosphorylation and activity. Still heavily phosphorylated at Tyr-177. Does not rescues inhibition of O-glycosylation in MAPK15-depleted cells; when associated with F-177.", "evidence": [ { "database": "UniProtKB", "id": "Q8TD08", "url": "https://www.uniprot.org/uniprotkb/Q8TD08" }, { "database": "PubMed", "id": "24618899", "url": "https://pubmed.ncbi.nlm.nih.gov/24618899" }, { "database": "PubMed", "id": "11875070", "url": "https://pubmed.ncbi.nlm.nih.gov/11875070" }, { "database": "PubMed", "id": "16336213", "url": "https://pubmed.ncbi.nlm.nih.gov/16336213" } ], "uniprot_canonical_ac": "Q8TD08-1" }, { "start_pos": 177, "end_pos": 177, "sequence_org": "Y", "sequence_mut": "A", "comment": "Loss of autophosphorylation and activity. 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"field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Characterization of the reversible phosphorylation and activation of ERK8.", "journal": "The Biochemical journal", "date": "2006", "authors": "Klevernic IV, Stafford MJ, Morrice N, Peggie M, Morton S, Cohen P", "reference": { "type": "PubMed", "id": "16336213", "url": "https://pubmed.ncbi.nlm.nih.gov/16336213" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8TD08-1", "protein_name": "Mitogen-activated protein kinase 15", "gene_name": "MAPK15", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8TD08", "url": "https://www.uniprot.org/uniprotkb/Q8TD08" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 155, "end_pos": 155, "sequence_org": "D", "sequence_mut": "A", "comment": "Unable to induce the formation of autophagosomal structures. Is able to bind to MAP1LC3B and to colocalize with this protein to autophagosomal structures. Does not induce phosphorylation by methyl methanesulfonate. Loas of phosphorylation. Dominant negative mutant. Not phosphorylated at Thr-175 and Tyr-177.", "evidence": [ { "database": "UniProtKB", "id": "Q8TD08", "url": "https://www.uniprot.org/uniprotkb/Q8TD08" }, { "database": "PubMed", "id": "22948227", "url": "https://pubmed.ncbi.nlm.nih.gov/22948227" }, { "database": "PubMed", "id": "16336213", "url": "https://pubmed.ncbi.nlm.nih.gov/16336213" }, { "database": "PubMed", "id": "19166846", "url": "https://pubmed.ncbi.nlm.nih.gov/19166846" } ], "uniprot_canonical_ac": "Q8TD08-1" }, { "start_pos": 175, "end_pos": 175, "sequence_org": "T", "sequence_mut": "A", "comment": "Loss of autophosphorylation and activity. Still heavily phosphorylated at Tyr-177. Does not rescues inhibition of O-glycosylation in MAPK15-depleted cells; when associated with F-177.", "evidence": [ { "database": "UniProtKB", "id": "Q8TD08", "url": "https://www.uniprot.org/uniprotkb/Q8TD08" }, { "database": "PubMed", "id": "24618899", "url": "https://pubmed.ncbi.nlm.nih.gov/24618899" }, { "database": "PubMed", "id": "11875070", "url": "https://pubmed.ncbi.nlm.nih.gov/11875070" }, { "database": "PubMed", "id": "16336213", "url": "https://pubmed.ncbi.nlm.nih.gov/16336213" } ], "uniprot_canonical_ac": "Q8TD08-1" }, { "start_pos": 177, "end_pos": 177, "sequence_org": "Y", "sequence_mut": "A", "comment": "Loss of autophosphorylation and activity. Heavily phosphorylated at Thr-175.", "evidence": [ { "database": "UniProtKB", "id": "Q8TD08", "url": "https://www.uniprot.org/uniprotkb/Q8TD08" }, { "database": "PubMed", "id": "11875070", "url": "https://pubmed.ncbi.nlm.nih.gov/11875070" }, { "database": "PubMed", "id": "16336213", "url": "https://pubmed.ncbi.nlm.nih.gov/16336213" } ], "uniprot_canonical_ac": "Q8TD08-1" }, { "start_pos": 42, "end_pos": 42, "sequence_org": "K", "sequence_mut": "A", "comment": "Not phosphorylated at Thr-175 and Tyr-177.", "evidence": [ { "database": "UniProtKB", "id": "Q8TD08", "url": "https://www.uniprot.org/uniprotkb/Q8TD08" }, { "database": "PubMed", "id": "16336213", "url": "https://pubmed.ncbi.nlm.nih.gov/16336213" } ], "uniprot_canonical_ac": "Q8TD08-1" } ], "phosphorylation": [ { "start_pos": 175, "end_pos": 175, "kinase_uniprot_canonical_ac": "Q8TD08-1", "kinase_gene_name": "MAPK15", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q8TD08", "url": 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"title": "Ligand interaction scan (LIScan) in the study of ERK8.", "journal": "Biochemical and biophysical research communications", "date": "2010-08-13", "authors": "Erster Oran, Seger Rony, Liscovitch Mordechai", "reference": { "type": "PubMed", "id": "20638370", "url": "https://pubmed.ncbi.nlm.nih.gov/20638370" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8TD08-1", "protein_name": "Mitogen-activated protein kinase 15", "gene_name": "MAPK15", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8TD08", "url": "https://www.uniprot.org/uniprotkb/Q8TD08" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.20638370", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": 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