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    {
        "title": "An ERK2 docking site in the Pointed domain distinguishes a subset of ETS transcription factors.",
        "journal": "Genes &amp; development",
        "date": "2002",
        "authors": "Seidel JJ, Graves BJ",
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        "title": "Transcriptional regulation of the human tumor suppressor p14(ARF) by E2F1, E2F2, E2F3, and Sp1-like factors.",
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        "date": "2002",
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        "title": "Evidence of functional modulation of the MEKK/JNK/cJun signaling cascade by the low density lipoprotein receptor-related protein (LRP).",
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    {
        "title": "Acetylation of p53 inhibits its ubiquitination by Mdm2.",
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        "authors": "Li M, Luo J, Brooks CL, Gu W",
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        "abstract": "",
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    {
        "title": "Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein.",
        "journal": "Genes &amp; development",
        "date": "2002",
        "authors": "Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D",
        "reference": {
            "type": "PubMed",
            "id": "12435631",
            "url": "https://pubmed.ncbi.nlm.nih.gov/12435631"
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            {
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            {
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            {
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            {
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            {
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            {
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            {
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                "uniprot_canonical_ac": "Q8N257-1",
                "protein_name": "Histone H2B type 3-B",
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                "tax_name": "Human"
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            {
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                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "Q99878-1",
                "protein_name": "Histone H2A type 1-J",
                "gene_name": "H2AC14",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q99880-1",
                "protein_name": "Histone H2B type 1-L",
                "gene_name": "H2BC13",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q15759-1",
                "protein_name": "Mitogen-activated protein kinase 11",
                "gene_name": "MAPK11",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q15022-1",
                "protein_name": "Polycomb protein SUZ12",
                "gene_name": "SUZ12",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P01100-1",
                "protein_name": "Protein c-Fos",
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                "tax_name": "Human"
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                "protein_name": "Transcription factor Jun",
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                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "O15151-1",
                "protein_name": "Protein Mdm4",
                "gene_name": "MDM4",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O00257-1",
                "protein_name": "E3 SUMO-protein ligase CBX4",
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                "protein_name": "Mitogen-activated protein kinase kinase kinase 5",
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                "tax_name": "Human"
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                "protein_name": "Polyubiquitin-C",
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                "tax_name": "Human"
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                "protein_name": "Cellular tumor antigen p53",
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                "name": "Homo sapiens",
                "taxid": 9606,
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                        "url": "https://www.uniprot.org/uniprotkb/Q9HCK5"
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                "common_name": "Human",
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                "reference_species": "Homo sapiens [9606]"
            }
        ],
        "mutagenesis": [
            {
                "start_pos": 588,
                "end_pos": 588,
                "sequence_org": "C",
                "sequence_mut": "Y",
                "comment": "Strongly impairs methyltransferase activity towards 'Lys-27' of histone H3.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q15910",
                        "url": "https://www.uniprot.org/uniprotkb/Q15910"
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                    {
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                        "id": "12435631",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12435631"
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                "start_pos": 689,
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                "sequence_mut": "A",
                "comment": "Abrogates methyltransferase activity.",
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                        "id": "Q15910",
                        "url": "https://www.uniprot.org/uniprotkb/Q15910"
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                    {
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                        "id": "12435631",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12435631"
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                    {
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                        "id": "18285464",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/18285464"
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        ],
        "record_id": "pubmed.12435631",
        "abstract": "",
        "glycosylation": [],
        "snv": [],
        "phosphorylation": [],
        "glycation": [],
        "section_stats": [
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    {
        "title": "Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions.",
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    {
        "title": "Regulation of PRAK subcellular location by p38 MAP kinases.",
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        "authors": "New L, Jiang Y, Han J",
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        "title": "EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer.",
        "journal": "The EMBO journal",
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        "authors": "Bracken AP, Pasini D, Capra M, Prosperini E, Colli E, Helin K",
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        "title": "MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1.",
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    {
        "title": "Physical association of the patient-specific GATA1 mutants with RUNX1 in acute megakaryoblastic leukemia accompanying Down syndrome.",
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        "title": "Ubiquitination regulates PTEN nuclear import and tumor suppression.",
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    {
        "title": "Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus.",
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        "authors": "Dietrich N, Bracken AP, Trinh E, Schjerling CK, Koseki H, Rappsilber J, Helin K, Hansen KH",
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    {
        "title": "The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells.",
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        "authors": "Bracken AP, Kleine-Kohlbrecher D, Dietrich N, Pasini D, Gargiulo G, Beekman C, Theilgaard-Monch K, Minucci S, Porse BT, Marine JC, Hansen KH, Helin K",
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    {
        "title": "Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases.",
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        "date": "2007",
        "authors": "Lefort K, Mandinova A, Ostano P, Kolev V, Calpini V, Kolfschoten I, Devgan V, Lieb J, Raffoul W, Hohl D, Neel V, Garlick J, Chiorino G, Dotto GP",
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        "title": "Molecular basis of MAPK-activated protein kinase 2:p38 assembly.",
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        "title": "STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression.",
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        "title": "TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms.",
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        "title": "Systematic identification of mRNAs recruited to argonaute 2 by specific microRNAs and corresponding changes in transcript abundance.",
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        "title": "The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network.",
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    {
        "title": "NOTCH3 expression is induced in mural cells through an autoregulatory loop that requires endothelial-expressed JAGGED1.",
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        "date": "2009",
        "authors": "Liu H, Kennard S, Lilly B",
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    {
        "title": "Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS.",
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    {
        "title": "DeltaNp63alpha repression of the Notch1 gene supports the proliferative capacity of normal human keratinocytes and cervical cancer cells.",
        "journal": "Cancer research",
        "date": "2010",
        "authors": "Yugawa T, Narisawa-Saito M, Yoshimatsu Y, Haga K, Ohno S, Egawa N, Fujita M, Kiyono T",
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        "record_id": "pubmed.20442293",
        "abstract": "",
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