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"end_pos": 103, "sequence_org": "W", "sequence_mut": "A", "comment": "In WQH to A mutant: Increased NAD(+)-binding to ARM repeats, leading to decreased NAD(+) hydrolase activity; when associated with A-150 and A-190.", "evidence": [ { "database": "UniProtKB", "id": "Q6SZW1", "url": "https://www.uniprot.org/uniprotkb/Q6SZW1" }, { "database": "PubMed", "id": "33053563", "url": "https://pubmed.ncbi.nlm.nih.gov/33053563" } ], "uniprot_canonical_ac": "Q6SZW1-1" }, { "start_pos": 110, "end_pos": 110, "sequence_org": "R", "sequence_mut": "A", "comment": "In RRK to A mutant: Slightly reduced NAD(+)-binding to ARM repeats; when associated with A-157 and A-193.", "evidence": [ { "database": "UniProtKB", "id": "Q6SZW1", "url": "https://www.uniprot.org/uniprotkb/Q6SZW1" }, { "database": "PubMed", "id": "33053563", "url": "https://pubmed.ncbi.nlm.nih.gov/33053563" } ], "uniprot_canonical_ac": "Q6SZW1-1" }, { "start_pos": 110, "end_pos": 110, "sequence_org": "R", "sequence_mut": "E", "comment": "In 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caused by disrupted interaction between the TIR domain and ARM repeats.", "evidence": [ { "database": "UniProtKB", "id": "Q6SZW1", "url": "https://www.uniprot.org/uniprotkb/Q6SZW1" }, { "database": "PubMed", "id": "33053563", "url": "https://pubmed.ncbi.nlm.nih.gov/33053563" } ], "uniprot_canonical_ac": "Q6SZW1-1" }, { "start_pos": 259, "end_pos": 259, "sequence_org": "F", "sequence_mut": "A", "comment": "No effect on octamer formation. 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"glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The SARM1 TIR domain produces glycocyclic ADPR molecules as minor products.", "journal": "PloS one", "date": "2024", "authors": "Garb Jeremy, Amitai Gil, Lu Allen, Ofir Gal, Brandis Alexander, Mehlman Tevie, Kranzusch Philip J, Sorek Rotem", "reference": { "type": "PubMed", "id": "38635746", "url": "https://pubmed.ncbi.nlm.nih.gov/38635746" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q6SZW1-1", "protein_name": "NAD(+) hydrolase SARM1", "gene_name": "SARM1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q6SZW1", "url": "https://www.uniprot.org/uniprotkb/Q6SZW1" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.38635746", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] 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Biol. Chem.", "date": "2001", "authors": "Briknarov\u00e1 K, Gehrmann M, B\u00e1nyai L, Tordai H, Patthy L, Llin\u00e1s M", "reference": { "type": "PubMed", "id": "11320090", "url": "https://pubmed.ncbi.nlm.nih.gov/11320090" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P08253-1", "protein_name": "72 kDa type IV collagenase", "gene_name": "MMP2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P08253", "url": "https://www.uniprot.org/uniprotkb/P08253" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11320090", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { 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Binding properties of recombinant gelatinase A C domain to extracellular matrix and basement membrane components.", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Wallon UM, Overall CM", "reference": { "type": "PubMed", "id": "9054449", "url": "https://pubmed.ncbi.nlm.nih.gov/9054449" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P08253-1", "protein_name": "72 kDa type IV collagenase", "gene_name": "MMP2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P08253", "url": "https://www.uniprot.org/uniprotkb/P08253" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.9054449", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", 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11q13.", "journal": "Genomics", "date": "1992", "authors": "Spencer S R, Taylor J B, Cowell I G, Xia C L, Pemble S E, Ketterer B", "reference": { "type": "PubMed", "id": "1478657", "url": "https://pubmed.ncbi.nlm.nih.gov/1478657" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P49821-1", "protein_name": "NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial", "gene_name": "NDUFV1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P49821", "url": "https://www.uniprot.org/uniprotkb/P49821" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.1478657", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", 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Proliferation and Restrains Apoptosis in Osteosarcoma by Regulating p38alphaMAPK Pathway.", "journal": "Technology in cancer research & treatment", "date": "2021", "authors": "Li T, Li N, Wang L, Li J, Zhang X", "reference": { "type": "PubMed", "id": "33596786", "url": "https://pubmed.ncbi.nlm.nih.gov/33596786" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q99549-1", "protein_name": "M-phase phosphoprotein 8", "gene_name": "MPHOSPH8", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q99549", "url": "https://www.uniprot.org/uniprotkb/Q99549" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.33596786", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", 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sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P50226", "url": "https://www.uniprot.org/uniprotkb/P50226" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.9119390", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": 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