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        ],
        "species": [
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                "name": "Homo sapiens",
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                "reference_species": "Homo sapiens [9606]"
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                "comment": "Abolishes neuroprotective activity.",
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            {
                "start_pos": 13,
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                "sequence_org": "T",
                "sequence_mut": "A",
                "comment": "Abolishes neuroprotective activity.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q8IVG9",
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                    {
                        "database": "PubMed",
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                    {
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                "uniprot_canonical_ac": "A0A3G1DJQ2-1"
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            {
                "start_pos": 14,
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                "sequence_org": "I",
                "sequence_mut": "A",
                "comment": "Abolishes neuroprotective activity.",
                "evidence": [
                    {
                        "database": "UniProtKB",
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                    {
                        "database": "PubMed",
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                    {
                        "database": "PubMed",
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                ],
                "uniprot_canonical_ac": "A0A3G1DJQ2-1"
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            {
                "start_pos": 14,
                "end_pos": 14,
                "sequence_org": "I",
                "sequence_mut": "E",
                "comment": "Abolishes neuroprotective activity.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q8IVG9",
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                    {
                        "database": "PubMed",
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                    {
                        "database": "PubMed",
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                "uniprot_canonical_ac": "A0A3G1DJQ2-1"
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            {
                "start_pos": 14,
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                "sequence_org": "I",
                "sequence_mut": "G",
                "comment": "Potentiates neuroprotective activity. Increased inhibition of amyloid-beta protein 40 fibril formation. Reduced levels of amyloid-beta 42 protein. Affects fiber formation with BAX with fewer fibers running in parallel. Affects fiber formation with BID with formation of shorter fibers. No effect on binding to BID or on BID-induced caspase activation and mitochondrial release of SMAC. Does not affect interaction with FPR2 or FPR3.",
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                    {
                        "database": "UniProtKB",
                        "id": "Q8IVG9",
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                    {
                        "database": "PubMed",
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                    {
                        "database": "PubMed",
                        "id": "15661737",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/15661737"
                    },
                    {
                        "database": "PubMed",
                        "id": "28282805",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/28282805"
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                    {
                        "database": "PubMed",
                        "id": "31690630",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/31690630"
                    },
                    {
                        "database": "PubMed",
                        "id": "27349871",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/27349871"
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                    {
                        "database": "PubMed",
                        "id": "15465011",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/15465011"
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                    {
                        "database": "PubMed",
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                        "url": "https://pubmed.ncbi.nlm.nih.gov/11717357"
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                "uniprot_canonical_ac": "A0A3G1DJQ2-1"
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            {
                "start_pos": 14,
                "end_pos": 14,
                "sequence_org": "I",
                "sequence_mut": "P",
                "comment": "Abolishes neuroprotective activity.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q8IVG9",
                        "url": "https://www.uniprot.org/uniprotkb/Q8IVG9"
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                    {
                        "database": "PubMed",
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                    {
                        "database": "PubMed",
                        "id": "12787071",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12787071"
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                    {
                        "database": "PubMed",
                        "id": "11717357",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11717357"
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                "uniprot_canonical_ac": "A0A3G1DJQ2-1"
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            {
                "start_pos": 14,
                "end_pos": 14,
                "sequence_org": "I",
                "sequence_mut": "R",
                "comment": "Abolishes neuroprotective activity.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q8IVG9",
                        "url": "https://www.uniprot.org/uniprotkb/Q8IVG9"
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                    {
                        "database": "PubMed",
                        "id": "12860203",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12860203"
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                    {
                        "database": "PubMed",
                        "id": "12787071",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12787071"
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                    {
                        "database": "PubMed",
                        "id": "11717357",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11717357"
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                "uniprot_canonical_ac": "A0A3G1DJQ2-1"
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            {
                "start_pos": 14,
                "end_pos": 14,
                "sequence_org": "I",
                "sequence_mut": "W",
                "comment": "Abolishes neuroprotective activity.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q8IVG9",
                        "url": "https://www.uniprot.org/uniprotkb/Q8IVG9"
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                    {
                        "database": "PubMed",
                        "id": "12860203",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12860203"
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                    {
                        "database": "PubMed",
                        "id": "12787071",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12787071"
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                    {
                        "database": "PubMed",
                        "id": "11717357",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11717357"
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                ],
                "uniprot_canonical_ac": "A0A3G1DJQ2-1"
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            {
                "start_pos": 19,
                "end_pos": 19,
                "sequence_org": "G",
                "sequence_mut": "A",
                "comment": "Abolishes neuroprotective activity.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q8IVG9",
                        "url": "https://www.uniprot.org/uniprotkb/Q8IVG9"
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                    {
                        "database": "PubMed",
                        "id": "12860203",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12860203"
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                    {
                        "database": "PubMed",
                        "id": "11717357",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11717357"
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                ],
                "uniprot_canonical_ac": "A0A3G1DJQ2-1"
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            {
                "start_pos": 19,
                "end_pos": 24,
                "sequence_org": "GFNFYR",
                "sequence_mut": "",
                "comment": "Abolishes neuroprotective activity.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q8IVG9",
                        "url": "https://www.uniprot.org/uniprotkb/Q8IVG9"
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                    {
                        "database": "PubMed",
                        "id": "11717357",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11717357"
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                ],
                "uniprot_canonical_ac": "A0A3G1DJQ2-1"
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            {
                "start_pos": 1,
                "end_pos": 2,
                "sequence_org": "ML",
                "sequence_mut": "",
                "comment": "No effect on neuroprotective activity.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q8IVG9",
                        "url": "https://www.uniprot.org/uniprotkb/Q8IVG9"
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                    {
                        "database": "PubMed",
                        "id": "11717357",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11717357"
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                ],
                "uniprot_canonical_ac": "A0A3G1DJQ2-1"
            },
            {
                "start_pos": 1,
                "end_pos": 3,
                "sequence_org": "MLG",
                "sequence_mut": "",
                "comment": "Abolishes neuroprotective activity.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q8IVG9",
                        "url": "https://www.uniprot.org/uniprotkb/Q8IVG9"
                    },
                    {
                        "database": "PubMed",
                        "id": "11717357",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11717357"
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                ],
                "uniprot_canonical_ac": "A0A3G1DJQ2-1"
            },
            {
                "start_pos": 20,
                "end_pos": 24,
                "sequence_org": "FNFYR",
                "sequence_mut": "",
                "comment": "No effect on neuroprotective activity.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q8IVG9",
                        "url": "https://www.uniprot.org/uniprotkb/Q8IVG9"
                    },
                    {
                        "database": "PubMed",
                        "id": "11717357",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11717357"
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                ],
                "uniprot_canonical_ac": "A0A3G1DJQ2-1"
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            {
                "start_pos": 3,
                "end_pos": 3,
                "sequence_org": "G",
                "sequence_mut": "A",
                "comment": "Abolishes neuroprotective activity.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q8IVG9",
                        "url": "https://www.uniprot.org/uniprotkb/Q8IVG9"
                    },
                    {
                        "database": "PubMed",
                        "id": "12860203",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12860203"
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                    {
                        "database": "PubMed",
                        "id": "11717357",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11717357"
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                ],
                "uniprot_canonical_ac": "A0A3G1DJQ2-1"
            },
            {
                "start_pos": 4,
                "end_pos": 6,
                "sequence_org": "YNF",
                "sequence_mut": "AGA",
                "comment": "Potentiates neuroprotective activity.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q8IVG9",
                        "url": "https://www.uniprot.org/uniprotkb/Q8IVG9"
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                    {
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                        "id": "11717357",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11717357"
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                ],
                "uniprot_canonical_ac": "A0A3G1DJQ2-1"
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            {
                "start_pos": 8,
                "end_pos": 8,
                "sequence_org": "S",
                "sequence_mut": "A",
                "comment": "Abolishes neuroprotective activity. Formation of short irregularly shaped fibers with BAX with fibers showing non-uniform diameters. Formation of thin irregularly kinked fibers with BID.",
                "evidence": [
                    {
                        "database": "UniProtKB",
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                        "url": "https://www.uniprot.org/uniprotkb/Q8IVG9"
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                        "database": "PubMed",
                        "id": "12732850",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12732850"
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                    {
                        "database": "PubMed",
                        "id": "33106313",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/33106313"
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                    {
                        "database": "PubMed",
                        "id": "31690630",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/31690630"
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                    {
                        "database": "PubMed",
                        "id": "12860203",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12860203"
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                    {
                        "database": "PubMed",
                        "id": "11717357",
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                "uniprot_canonical_ac": "A0A3G1DJQ2-1"
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            {
                "start_pos": 8,
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                "sequence_org": "S",
                "sequence_mut": "D",
                "comment": "Abolishes neuroprotective activity.",
                "evidence": [
                    {
                        "database": "UniProtKB",
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                    {
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                        "url": "https://pubmed.ncbi.nlm.nih.gov/11717357"
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                ],
                "uniprot_canonical_ac": "A0A3G1DJQ2-1"
            },
            {
                "start_pos": 8,
                "end_pos": 8,
                "sequence_org": "S",
                "sequence_mut": "E",
                "comment": "Abolishes neuroprotective activity.",
                "evidence": [
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                        "database": "UniProtKB",
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                    {
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                "uniprot_canonical_ac": "A0A3G1DJQ2-1"
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            {
                "start_pos": 8,
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                "sequence_org": "S",
                "sequence_mut": "F",
                "comment": "Abolishes neuroprotective activity.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q8IVG9",
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                    {
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                "uniprot_canonical_ac": "A0A3G1DJQ2-1"
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            {
                "start_pos": 8,
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                "sequence_org": "S",
                "sequence_mut": "G",
                "comment": "Abolishes neuroprotective activity.",
                "evidence": [
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                        "database": "UniProtKB",
                        "id": "Q8IVG9",
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                    {
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                ],
                "uniprot_canonical_ac": "A0A3G1DJQ2-1"
            },
            {
                "start_pos": 8,
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                "sequence_org": "S",
                "sequence_mut": "H",
                "comment": "Significantly reduces neuroprotective activity.",
                "evidence": [
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                        "database": "UniProtKB",
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                    {
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                "uniprot_canonical_ac": "A0A3G1DJQ2-1"
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            {
                "start_pos": 8,
                "end_pos": 8,
                "sequence_org": "S",
                "sequence_mut": "I",
                "comment": "Abolishes neuroprotective activity.",
                "evidence": [
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                        "database": "UniProtKB",
                        "id": "Q8IVG9",
                        "url": "https://www.uniprot.org/uniprotkb/Q8IVG9"
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                    {
                        "database": "PubMed",
                        "id": "12732850",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12732850"
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                    {
                        "database": "PubMed",
                        "id": "11717357",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11717357"
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                ],
                "uniprot_canonical_ac": "A0A3G1DJQ2-1"
            },
            {
                "start_pos": 8,
                "end_pos": 8,
                "sequence_org": "S",
                "sequence_mut": "K",
                "comment": "No effect on neuroprotective activity.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q8IVG9",
                        "url": "https://www.uniprot.org/uniprotkb/Q8IVG9"
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                    {
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                        "id": "12732850",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12732850"
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                    {
                        "database": "PubMed",
                        "id": "11717357",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11717357"
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                ],
                "uniprot_canonical_ac": "A0A3G1DJQ2-1"
            },
            {
                "start_pos": 8,
                "end_pos": 8,
                "sequence_org": "S",
                "sequence_mut": "L",
                "comment": "Abolishes neuroprotective activity.",
                "evidence": [
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                        "database": "UniProtKB",
                        "id": "Q8IVG9",
                        "url": "https://www.uniprot.org/uniprotkb/Q8IVG9"
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                    {
                        "database": "PubMed",
                        "id": "12732850",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12732850"
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                    {
                        "database": "PubMed",
                        "id": "11717357",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11717357"
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                ],
                "uniprot_canonical_ac": "A0A3G1DJQ2-1"
            },
            {
                "start_pos": 8,
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                "sequence_org": "S",
                "sequence_mut": "M",
                "comment": "Abolishes neuroprotective activity.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q8IVG9",
                        "url": "https://www.uniprot.org/uniprotkb/Q8IVG9"
                    },
                    {
                        "database": "PubMed",
                        "id": "12732850",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12732850"
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                    {
                        "database": "PubMed",
                        "id": "11717357",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11717357"
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                ],
                "uniprot_canonical_ac": "A0A3G1DJQ2-1"
            },
            {
                "start_pos": 8,
                "end_pos": 8,
                "sequence_org": "S",
                "sequence_mut": "N",
                "comment": "Abolishes neuroprotective activity.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q8IVG9",
                        "url": "https://www.uniprot.org/uniprotkb/Q8IVG9"
                    },
                    {
                        "database": "PubMed",
                        "id": "12732850",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12732850"
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                    {
                        "database": "PubMed",
                        "id": "11717357",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11717357"
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                ],
                "uniprot_canonical_ac": "A0A3G1DJQ2-1"
            },
            {
                "start_pos": 8,
                "end_pos": 8,
                "sequence_org": "S",
                "sequence_mut": "P",
                "comment": "Abolishes neuroprotective activity and interaction with BAX and BID. Abolishes BID-induced caspase activation and mitochondrial release of SMAC. Greatly reduced interaction with BIM. Abolishes BIM-induced caspase activation and apoptosis.",
                "evidence": [
                    {
                        "database": "UniProtKB",
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                        "url": "https://www.uniprot.org/uniprotkb/Q8IVG9"
                    },
                    {
                        "database": "PubMed",
                        "id": "12732850",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12732850"
                    },
                    {
                        "database": "PubMed",
                        "id": "15661737",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/15661737"
                    },
                    {
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                        "id": "15661735",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/15661735"
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                    {
                        "database": "PubMed",
                        "id": "11717357",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11717357"
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                ],
                "uniprot_canonical_ac": "A0A3G1DJQ2-1"
            },
            {
                "start_pos": 8,
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                "sequence_org": "S",
                "sequence_mut": "Q",
                "comment": "Abolishes neuroprotective activity.",
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