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"type": "PubMed", "id": "15448698", "url": "https://pubmed.ncbi.nlm.nih.gov/15448698" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P49841-1", "protein_name": "Glycogen synthase kinase-3 beta", "gene_name": "GSK3B", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95863-1", "protein_name": "Zinc finger protein SNAI1", "gene_name": "SNAI1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y297-1", "protein_name": "F-box/WD repeat-containing protein 1A", "gene_name": "BTRC", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P49841", "url": "https://www.uniprot.org/uniprotkb/P49841" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 100, "end_pos": 100, "sequence_org": "S", "sequence_mut": "A", "comment": "Lower sensitivity to BTRC-triggered degradation and impaired phosphorylation by GSK3B; 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Lower sensitivity to BTRC-triggered degradation, impaired phosphorylation by GSK3B and loss of cytoplasmic localization; when associated with A-96; A-100; A-107; A-115 and A-119.", "evidence": [ { "database": "UniProtKB", "id": "O95863", "url": "https://www.uniprot.org/uniprotkb/O95863" }, { "database": "PubMed", "id": "15448698", "url": "https://pubmed.ncbi.nlm.nih.gov/15448698" }, { "database": "PubMed", "id": "29059170", "url": "https://pubmed.ncbi.nlm.nih.gov/29059170" }, { "database": "PubMed", "id": "25827072", "url": "https://pubmed.ncbi.nlm.nih.gov/25827072" } ], "uniprot_canonical_ac": "O95863-1" }, { "start_pos": 111, "end_pos": 111, "sequence_org": "S", "sequence_mut": "E", "comment": "Predominantly localized to the cytoplasm; when associated with E-107; E-115 and E-119.", "evidence": [ { "database": "UniProtKB", "id": "O95863", "url": "https://www.uniprot.org/uniprotkb/O95863" }, { "database": "PubMed", "id": "15448698", "url": "https://pubmed.ncbi.nlm.nih.gov/15448698" } ], "uniprot_canonical_ac": "O95863-1" }, { "start_pos": 115, "end_pos": 115, "sequence_org": "S", "sequence_mut": "A", "comment": "Lower sensitivity to BTRC-triggered degradation, impaired phosphorylation by GSK3B and loss of cytoplasmic localization; when associated with A-107; A-111 and A-119. 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Lower sensitivity to BTRC-triggered degradation, impaired phosphorylation by GSK3B and loss of cytoplasmic localization; when associated with A-96; A-100; A-107; A-111 and A-115.", "evidence": [ { "database": "UniProtKB", "id": "O95863", "url": "https://www.uniprot.org/uniprotkb/O95863" }, { "database": "PubMed", "id": "15448698", "url": "https://pubmed.ncbi.nlm.nih.gov/15448698" } ], "uniprot_canonical_ac": "O95863-1" }, { "start_pos": 119, "end_pos": 119, "sequence_org": "S", "sequence_mut": "E", "comment": "Predominantly localized to the cytoplasm; when associated with E-107; E-111 and E-115.", "evidence": [ { "database": "UniProtKB", "id": "O95863", "url": "https://www.uniprot.org/uniprotkb/O95863" }, { "database": "PubMed", "id": "15448698", "url": "https://pubmed.ncbi.nlm.nih.gov/15448698" }, { "database": "PubMed", "id": "29059170", "url": "https://pubmed.ncbi.nlm.nih.gov/29059170" }, { "database": "PubMed", "id": "25827072", "url": "https://pubmed.ncbi.nlm.nih.gov/25827072" } ], "uniprot_canonical_ac": "O95863-1" }, { "start_pos": 96, "end_pos": 96, "sequence_org": "S", "sequence_mut": "A", "comment": "Abolishes recognition and ubiquitination by BTRC which increases steady state level and half-life. Preferentially localizes to the nucleus. Induces a more aggressive tissue invasion program. Lower sensitivity to BTRC-triggered degradation, impairs phosphorylation by GSK3B and does not affect NOTCH1-induced degradation; when associated with A-100. 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