[ { "title": "Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.", "journal": "FEBS Lett.", "date": "1990", "authors": "Hessing M, van 't Veer C, Hackeng TM, Bouma BN, Iwanaga S", "reference": { "type": "PubMed", "id": "1699796", "url": "https://pubmed.ncbi.nlm.nih.gov/1699796" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P0C0L5-1", "protein_name": "Complement C4-B", "gene_name": "C4B_2; C4B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0C0L4-1", "protein_name": "Complement C4-A", "gene_name": "C4A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P0C0L5", "url": "https://www.uniprot.org/uniprotkb/P0C0L5" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.1699796", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European Americans.", "journal": "Am. J. Hum. Genet.", "date": "2007", "authors": "Yang Yan, Chung Erwin K, Wu Yee Ling, Savelli Stephanie L, Nagaraja Haikady N, Zhou Bi, Hebert Maddie, Jones Karla N, Shu Yaoling, Kitzmiller Kathryn, Blanchong Carol A, McBride Kim L, Higgins Gloria C, Rennebohm Robert M, Rice Robert R, Hackshaw Kevin V, Roubey Robert A S, Grossman Jennifer M, Tsao Betty P, Birmingham Daniel J, Rovin Brad H, Hebert Lee A, Yu C Yung", "reference": { "type": "PubMed", "id": "17503323", "url": "https://pubmed.ncbi.nlm.nih.gov/17503323" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P0C0L5-1", "protein_name": "Complement C4-B", "gene_name": "C4B_2; C4B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0C0L4-1", "protein_name": "Complement C4-A", "gene_name": "C4A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P0C0L5", "url": "https://www.uniprot.org/uniprotkb/P0C0L5" } ], "common_name": "Human", 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"Proceedings of the National Academy of Sciences of the United States of America", "date": "1990", "authors": "Carroll MC, Fathallah DM, Bergamaschini L, Alicot EM, Isenman DE", "reference": { "type": "PubMed", "id": "2395880", "url": "https://pubmed.ncbi.nlm.nih.gov/2395880" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P0C0L5-1", "protein_name": "Complement C4-B", "gene_name": "C4B_2; C4B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0C0L4-1", "protein_name": "Complement C4-A", "gene_name": "C4A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P0C0L5", "url": "https://www.uniprot.org/uniprotkb/P0C0L5" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 1120, "end_pos": 1120, "sequence_org": "L", "sequence_mut": "P", "comment": "No effect on hemolytic activity, nor on C1-dependent binding to IgG.", "evidence": [ { "database": "UniProtKB", "id": "P0C0L5", "url": "https://www.uniprot.org/uniprotkb/P0C0L5" }, { "database": "PubMed", "id": "2395880", "url": "https://pubmed.ncbi.nlm.nih.gov/2395880" } ], "uniprot_canonical_ac": "P0C0L5-1" }, { "start_pos": 1121, "end_pos": 1121, "sequence_org": "S", "sequence_mut": "C", "comment": "30-40% decrease in hemolytic activity and C1-dependent binding to IgG.", "evidence": [ { "database": "UniProtKB", "id": "P0C0L5", "url": "https://www.uniprot.org/uniprotkb/P0C0L5" }, { "database": "PubMed", "id": "2395880", "url": "https://pubmed.ncbi.nlm.nih.gov/2395880" } ], "uniprot_canonical_ac": "P0C0L5-1" }, { "start_pos": 1124, "end_pos": 1124, "sequence_org": "I", "sequence_mut": "A", "comment": "50-60% decrease in hemolytic activity and C1-dependent binding to IgG.", "evidence": [ { "database": "UniProtKB", "id": "P0C0L5", "url": "https://www.uniprot.org/uniprotkb/P0C0L5" }, { "database": "PubMed", "id": "2395880", "url": 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Med.", "date": "1988", "authors": "Klickstein L B, Bartow T J, Miletic V, Rabson L D, Smith J A, Fearon D T", "reference": { "type": "PubMed", "id": "2972794", "url": "https://pubmed.ncbi.nlm.nih.gov/2972794" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P0C0L5-1", "protein_name": "Complement C4-B", "gene_name": "C4B_2; C4B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P17927-1", "protein_name": "Complement receptor type 1", "gene_name": "CR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01024-1", "protein_name": "Complement C3", "gene_name": "C3", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P0C0L5", "url": "https://www.uniprot.org/uniprotkb/P0C0L5" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.2972794", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Complete C4B deficiency in black Americans with systemic lupus erythematosus.", "journal": "J. Rheumatol.", "date": "1988", "authors": "Wilson W A, Perez M C", "reference": { "type": "PubMed", "id": "3265961", "url": "https://pubmed.ncbi.nlm.nih.gov/3265961" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P0C0L5-1", "protein_name": "Complement C4-B", "gene_name": "C4B_2; C4B", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P0C0L5", "url": "https://www.uniprot.org/uniprotkb/P0C0L5" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.3265961", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "An ultrahigh-affinity complement C4b-specific nanobody inhibits in vivo assembly of the classical pathway proconvertase.", "journal": "J. Immunol.", "date": "2020", "authors": "Zarantonello Alessandra, Presumey Jessy, Simoni L\u00e9a, Yalcin Esra, Fox Rachel, Hansen Annette, Olesen Heidi Gytz, Thiel Steffen, Johnson Matthew B, Stevens Beth, Laursen Nick Stub, Carroll Michael C, Andersen Gregers R", "reference": { "type": "PubMed", "id": "32769120", "url": "https://pubmed.ncbi.nlm.nih.gov/32769120" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P0C0L5-1", "protein_name": "Complement C4-B", "gene_name": "C4B_2; C4B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0C0L4-1", "protein_name": "Complement C4-A", "gene_name": "C4A", "tax_name": "Human" }, { "uniprot_canonical_ac": "A0AAQ4VMX2-1", "protein_name": "Complement C4-A", "gene_name": "C4a", "tax_name": "Mouse" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P0C0L5", "url": "https://www.uniprot.org/uniprotkb/P0C0L5" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.32769120", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Serum complement component 3, complement component 4 and complement component 1q levels predict progressive visual field loss in older women with primary angle closure glaucoma.", "journal": "The British journal of ophthalmology", "date": "2022-01-11", "authors": "Li Shengjie, Qiu Yichao, Yu Jian, Shao Mingxi, Li Yingzhu, Cao Wenjun, Sun Xinghuai", "reference": { "type": "PubMed", "id": "35017157", "url": "https://pubmed.ncbi.nlm.nih.gov/35017157" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P0C0L5-1", "protein_name": "Complement C4-B", "gene_name": "C4B_2; 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U.S.A.", "date": "1981", "authors": "Harrison R A, Thomas M L, Tack B F", "reference": { "type": "PubMed", "id": "6950384", "url": "https://pubmed.ncbi.nlm.nih.gov/6950384" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P0C0L5-1", "protein_name": "Complement C4-B", "gene_name": "C4B_2; C4B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0C0L4-1", "protein_name": "Complement C4-A", "gene_name": "C4A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P0C0L5", "url": "https://www.uniprot.org/uniprotkb/P0C0L5" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.6950384", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.", "journal": "Biochem. J.", "date": "1981", "authors": "Campbell R D, Gagnon J, Porter R R", "reference": { "type": "PubMed", "id": "6978711", "url": "https://pubmed.ncbi.nlm.nih.gov/6978711" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P0C0L5-1", "protein_name": "Complement C4-B", "gene_name": "C4B_2; C4B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0C0L4-1", "protein_name": "Complement C4-A", "gene_name": "C4A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P0C0L5", "url": "https://www.uniprot.org/uniprotkb/P0C0L5" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.6978711", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Analysis of the functional domains of complement receptor type 1 (C3b/C4b receptor; CD35) by substitution mutagenesis.", "journal": "J. Biol. Chem.", "date": "1994", "authors": "Krych M, Clemenza L, Howdeshell D, Hauhart R, Hourcade D, Atkinson J P", "reference": { "type": "PubMed", "id": "8175757", "url": "https://pubmed.ncbi.nlm.nih.gov/8175757" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P0C0L5-1", "protein_name": "Complement C4-B", "gene_name": "C4B_2; C4B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P17927-1", "protein_name": "Complement receptor type 1", "gene_name": "CR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01024-1", "protein_name": "Complement C3", "gene_name": "C3", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P0C0L5", "url": "https://www.uniprot.org/uniprotkb/P0C0L5" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.8175757", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Complete sequence of the complement C4 gene from the HLA-A1, B8, C4AQ0, C4B1, DR3 haplotype.", "journal": "Immunogenetics", "date": "1996", "authors": "Ulgiati D, Townend DC, Christiansen FT, Dawkins RL, Abraham LJ", "reference": { "type": "PubMed", "id": "8575831", "url": "https://pubmed.ncbi.nlm.nih.gov/8575831" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P0C0L5-1", "protein_name": "Complement C4-B", "gene_name": "C4B_2; 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J. Haematol.", "date": "2009", "authors": "Arseneau Jean-Ren\u00e9, Laflamme Mark, Lewis Stephen M, Ma\u00efcas Emmanuel, Ouellette Rodney J", "reference": { "type": "PubMed", "id": "19725825", "url": "https://pubmed.ncbi.nlm.nih.gov/19725825" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q02548-1", "protein_name": "Paired box protein Pax-5", "gene_name": "PAX5", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q02548", "url": "https://www.uniprot.org/uniprotkb/Q02548" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.19725825", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", 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screening and RNA analyses.", "journal": "Journal of human genetics", "date": "2021", "authors": "Hammarsjo A, Pettersson M, Chitayat D, Handa A, Anderlid BM, Bartocci M, Basel D, Batkovskyte D, Beleza-Meireles A, Conner P, Eisfeldt J, Girisha KM, Chung BH, Horemuzova E, Hyodo H, Kornejeva L, Lagerstedt-Robinson K, Lin AE, Magnusson M, Moosa S, Nayak SS, Nilsson D, Ohashi H, Ohashi-Fukuda N, Stranneheim H, Taylan F, Traberg R, Voss U, Wirta V, Nordgren A, Nishimura G, Lindstrand A, Grigelioniene G", "reference": { "type": "PubMed", "id": "33875766", "url": "https://pubmed.ncbi.nlm.nih.gov/33875766" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q2KHM9-1", "protein_name": "Protein moonraker", "gene_name": "KIAA0753", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q2KHM9", "url": "https://www.uniprot.org/uniprotkb/Q2KHM9" } ], "common_name": "Human", "glygen_name": "Human", 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"field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "A ciliopathy complex builds distal appendages to initiate ciliogenesis.", "journal": "The Journal of cell biology", "date": "2021", "authors": "Kumar D, Rains A, Herranz-Perez V, Lu Q, Shi X, Swaney DL, Stevenson E, Krogan NJ, Huang B, Westlake C, Garcia-Verdugo JM, Yoder BK, Reiter JF", "reference": { "type": "PubMed", "id": "34241634", "url": "https://pubmed.ncbi.nlm.nih.gov/34241634" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q2KHM9-1", "protein_name": "Protein moonraker", "gene_name": "KIAA0753", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WXW3-1", "protein_name": "Progesterone-induced-blocking factor 1", "gene_name": "PIBF1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q2KHM9", "url": "https://www.uniprot.org/uniprotkb/Q2KHM9" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.34241634", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": 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Immunol.", "date": "2000", "authors": "Goitsuka R, Kanazashi H, Sasanuma H, Fujimura Y, Hidaka Y, Tatsuno A, Ra C, Hayashi K, Kitamura D", "reference": { "type": "PubMed", "id": "10744659", "url": "https://pubmed.ncbi.nlm.nih.gov/10744659" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q7Z7G1-1", "protein_name": "Cytokine-dependent hematopoietic cell linker", "gene_name": "CLNK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9QZE2-1", "protein_name": "Cytokine-dependent hematopoietic cell linker", "gene_name": "Clnk", "tax_name": "Mouse" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q7Z7G1", "url": "https://www.uniprot.org/uniprotkb/Q7Z7G1" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 101, "end_pos": 101, "sequence_org": "Y", "sequence_mut": "F", "comment": "Loss of phosphorylation and loss of interaction with PLCG1, PLCG2 and VAV. No effect on the suppression of natural killer cell activation and suppression of interferon-gamma production; when associated with F-69, F-96, F-153, F-174 and F-188.", "evidence": [ { "database": "UniProtKB", "id": "Q9QZE2", "url": "https://www.uniprot.org/uniprotkb/Q9QZE2" }, { "database": "PubMed", "id": "10744659", "url": "https://pubmed.ncbi.nlm.nih.gov/10744659" }, { "database": "PubMed", "id": "11463797", "url": "https://pubmed.ncbi.nlm.nih.gov/11463797" }, { "database": "PubMed", "id": "16439675", "url": "https://pubmed.ncbi.nlm.nih.gov/16439675" } ], "uniprot_canonical_ac": "Q9QZE2-1" }, { "start_pos": 153, "end_pos": 153, "sequence_org": "Y", "sequence_mut": "F", "comment": "Loss of phosphorylation and loss of interaction with PLCG1, PLCG2 and VAV. 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No effect on the suppression of natural killer cell activation and suppression of interferon-gamma production; when associated with F-69, F-96, F-101, F-153 and F-174.", "evidence": [ { "database": "UniProtKB", "id": "Q9QZE2", "url": "https://www.uniprot.org/uniprotkb/Q9QZE2" }, { "database": "PubMed", "id": "10744659", "url": "https://pubmed.ncbi.nlm.nih.gov/10744659" }, { "database": "PubMed", "id": "16439675", "url": "https://pubmed.ncbi.nlm.nih.gov/16439675" }, { "database": "PubMed", "id": "11463797", "url": "https://pubmed.ncbi.nlm.nih.gov/11463797" } ], "uniprot_canonical_ac": "Q9QZE2-1" }, { "start_pos": 69, "end_pos": 69, "sequence_org": "Y", "sequence_mut": "F", "comment": "Loss of phosphorylation and loss of interaction with PLCG1, PLCG2 and VAV. 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No effect on the suppression of natural killer cell activation and suppression of interferon-gamma production; when associated with F-69, F-101, F-153, F-174 and F-188.", "evidence": [ { "database": "UniProtKB", "id": "Q9QZE2", "url": "https://www.uniprot.org/uniprotkb/Q9QZE2" }, { "database": "PubMed", "id": "10744659", "url": "https://pubmed.ncbi.nlm.nih.gov/10744659" }, { "database": "PubMed", "id": "16439675", "url": "https://pubmed.ncbi.nlm.nih.gov/16439675" }, { "database": "PubMed", "id": "11463797", "url": "https://pubmed.ncbi.nlm.nih.gov/11463797" } ], "uniprot_canonical_ac": "Q9QZE2-1" } ], "record_id": "pubmed.10744659", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", 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J. 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"authors": "Zhang RL, Yang JP, Peng LX, Zheng LS, Xie P, Wang MY, Cao Y, Zhang ZL, Zhou FJ, Qian CN, Bao YX", "reference": { "type": "PubMed", "id": "27767378", "url": "https://pubmed.ncbi.nlm.nih.gov/27767378" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q96PU8-1", "protein_name": "KH domain-containing RNA-binding protein QKI", "gene_name": "QKI", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q96PU8", "url": "https://www.uniprot.org/uniprotkb/Q96PU8" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "biomarkers": [ { "best_biomarker_role": [ "prognostic" ], "biomarker_canonical_id": "AN6695", "assessed_biomarker_entity": [ "KH domain-containing RNA-binding protein QKI" ], "biomarker_id": "AN6695-1", "biomarker": [ "decreased QKI level" ], "condition": { "id": "DOID:263", "recommended_name": { "id": "DOID:263", 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Rep.", "date": "2011", "authors": "Shen YM, He X, Deng HX, Xie YP, Wang CT, Wei YQ, Zhao X", "reference": { "type": "PubMed", "id": "21109960", "url": "https://pubmed.ncbi.nlm.nih.gov/21109960" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q96M83-1", "protein_name": "Coiled-coil domain-containing protein 7", "gene_name": "CCDC7", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q96M83", "url": "https://www.uniprot.org/uniprotkb/Q96M83" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.21109960", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { 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Dyn.", "date": "1998", "authors": "Zhou J., Basora N., Herring-Gillam F.E., Perreault N., Vachon P.H., Beaulieu J.F., Bouatrouss Y., Pageot L.P., Simoneau A.", "reference": { "type": "PubMed", "id": "9671947", "url": "https://pubmed.ncbi.nlm.nih.gov/9671947" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q14031-1", "protein_name": "Collagen alpha-6(IV) chain", "gene_name": "COL4A6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P29400-1", "protein_name": "Collagen alpha-5(IV) chain", "gene_name": "COL4A5", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q14031", "url": "https://www.uniprot.org/uniprotkb/Q14031" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.9671947", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { 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