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        "title": "Drosophila dicer-2 cleavage is mediated by helicase- and dsRNA termini-dependent states that are modulated by Loquacious-PD.",
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        "authors": "Jakob Leonhard, Treiber Thomas, Treiber Nora, Gust Alexander, Kramm Kevin, Hansen Kerrin, Stotz Mathias, Wankerl Ludwig, Herzog Franz, Hannus Stefan, Grohmann Dina, Meister Gunter",
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        "title": "The Drosophila Dicer-1 Partner Loquacious Enhances miRNA Processing from Hairpins with Unstable Structures at the Dicing Site.",
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    {
        "title": "DSF nuclear receptor acts as a repressor in culture and in vivo.",
        "journal": "Developmental biology",
        "date": "2002",
        "authors": "Pitman JL, Tsai CC, Edeen PT, Finley KD, Evans RM, McKeown M",
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            "type": "PubMed",
            "id": "11977984",
            "url": "https://pubmed.ncbi.nlm.nih.gov/11977984"
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            }
        ],
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                "name": "Drosophila melanogaster",
                "taxid": 7227,
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                        "id": "Q9VML1",
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                ],
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                "reference_species": "Drosophila melanogaster [7227]"
            }
        ],
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                "start_pos": 102,
                "end_pos": 322,
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                "sequence_mut": "",
                "comment": "Strong increase in DNA binding.",
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                    {
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                "start_pos": 103,
                "end_pos": 691,
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                "sequence_mut": "",
                "comment": "Very strong increase in DNA binding.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q9VML1",
                        "url": "https://www.uniprot.org/uniprotkb/Q9VML1"
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                        "id": "11977984",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11977984"
                    }
                ],
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            {
                "start_pos": 172,
                "end_pos": 322,
                "sequence_org": "TQHISTHPPAPAAPPSGFHLTASGAQQGPAPPAGHLHHGGAGHQHATAFHHPGHGHALPAPHGGVVSNPGGNSSAISGSGPGSTLPFPSHLLHHNLIAEAASKLPGITATAVAAVVSSTSTPYASAAQTSSPSSNNHNYSSPSPSNSIQSI",
                "sequence_mut": "",
                "comment": "Slight increase in DNA binding.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q9VML1",
                        "url": "https://www.uniprot.org/uniprotkb/Q9VML1"
                    },
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                        "database": "PubMed",
                        "id": "11977984",
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                "start_pos": 173,
                "end_pos": 691,
                "sequence_org": "QHISTHPPAPAAPPSGFHLTASGAQQGPAPPAGHLHHGGAGHQHATAFHHPGHGHALPAPHGGVVSNPGGNSSAISGSGPGSTLPFPSHLLHHNLIAEAASKLPGITATAVAAVVSSTSTPYASAAQTSSPSSNNHNYSSPSPSNSIQSISSIGSRSGGGEEGLSLGSESPRVNVETETPSPSNSPPLSAGSISPAPTLTTSSGSPQHRQMSRHSLSEATTPPSHASLMICASNNNNNNNNNNNNGEHKQSSYTSGSPTPTTPTPPPPRSGVGSTCNTASSSSGFLELLLSPDKCQELIQYQVQHNTLLFPQQLLDSRLLSWEMLQETTARLLFMAVRWVKCLMPFQTLSKNDQHLLLQESWKELFLLNLAQWTIPLDLTPILESPLIRERVLQDEATQTEMKTIQEILCRFRQITPDGSEVGCMKAIALFAPETAGLCDVQPVEMLQDQAQCILSDHVRLRYPRQATRFGRLLLLLPSLRTIRAATIEALFFKETIGNVPIARLLRDMYTMEPAQVDK",
                "sequence_mut": "",
                "comment": "Increased DNA binding.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q9VML1",
                        "url": "https://www.uniprot.org/uniprotkb/Q9VML1"
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                        "id": "11977984",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11977984"
                    }
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                "start_pos": 244,
                "end_pos": 691,
                "sequence_org": "SSAISGSGPGSTLPFPSHLLHHNLIAEAASKLPGITATAVAAVVSSTSTPYASAAQTSSPSSNNHNYSSPSPSNSIQSISSIGSRSGGGEEGLSLGSESPRVNVETETPSPSNSPPLSAGSISPAPTLTTSSGSPQHRQMSRHSLSEATTPPSHASLMICASNNNNNNNNNNNNGEHKQSSYTSGSPTPTTPTPPPPRSGVGSTCNTASSSSGFLELLLSPDKCQELIQYQVQHNTLLFPQQLLDSRLLSWEMLQETTARLLFMAVRWVKCLMPFQTLSKNDQHLLLQESWKELFLLNLAQWTIPLDLTPILESPLIRERVLQDEATQTEMKTIQEILCRFRQITPDGSEVGCMKAIALFAPETAGLCDVQPVEMLQDQAQCILSDHVRLRYPRQATRFGRLLLLLPSLRTIRAATIEALFFKETIGNVPIARLLRDMYTMEPAQVDK",
                "sequence_mut": "",
                "comment": "Slight increase in DNA binding.",
                "evidence": [
                    {
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                        "id": "Q9VML1",
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                "start_pos": 24,
                "end_pos": 24,
                "sequence_org": "H",
                "sequence_mut": "Y",
                "comment": "In dsf7, greatly decreased DNA binding of fragment 1-102.",
                "evidence": [
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                        "id": "Q9VML1",
                        "url": "https://www.uniprot.org/uniprotkb/Q9VML1"
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                "sequence_mut": "",
                "comment": "Reduced DNA binding and weakly represses DNA transcription.",
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                "sequence_mut": "",
                "comment": "Reduced DNA binding.",
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    {
        "title": "dissatisfaction, a gene involved in sex-specific behavior and neural development of Drosophila melanogaster.",
        "journal": "Proceedings of the National Academy of Sciences of the United States of America",
        "date": "1997",
        "authors": "Finley KD, Taylor BJ, Milstein M, McKeown M",
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            }
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                "name": "Drosophila melanogaster",
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                "sequence_mut": "",
                "comment": "In dsf1; males and females are sterile due to abnormal courtship behaviors and defects in their sex-specific nervous system. Females display active resistance and rejection behaviors during courtship and copulation. Synapses are also absent on the circumferential muscles of the uterus which likely results in the observed egg-laying defect in which the mature eggs reach the uterus but females are unable to lay them. Males actively court both females and males, and during the final step of courtship display defects in abdominal curling which is required to make genital-genital contact with females. The observed slow abdominal bends during mating is likely due, at least in part, to abnormal innervation of the ventral longitudinal muscles of abdominal segment 5 (A5).",
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        "authors": "Finley KD, Edeen PT, Foss M, Gross E, Ghbeish N, Palmer RH, Taylor BJ, McKeown M",
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                "comment": "In dsf1; males and females are sterile due to abnormal courtship behaviors and defects in their sex-specific nervous system. Females display active resistance and rejection behaviors during courtship and copulation. Synapses are also absent on the circumferential muscles of the uterus which likely results in the observed egg-laying defect in which the mature eggs reach the uterus but females are unable to lay them. Males actively court both females and males, and during the final step of courtship display defects in abdominal curling which is required to make genital-genital contact with females. The observed slow abdominal bends during mating is likely due, at least in part, to abnormal innervation of the ventral longitudinal muscles of abdominal segment 5 (A5).",
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