[
    {
        "title": "Molecular cloning and functional characterization of human lymphotactin.",
        "journal": "Journal of immunology (Baltimore, Md. : 1950)",
        "date": "1995",
        "authors": "Kennedy J, Kelner GS, Kleyensteuber S, Schall TJ, Weiss MC, Yssel H, Schneider PV, Cocks BG, Bacon KB, Zlotnik A",
        "reference": {
            "type": "PubMed",
            "id": "7602097",
            "url": "https://pubmed.ncbi.nlm.nih.gov/7602097"
        },
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                "protein_name": "C-C chemokine receptor type 1",
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                "protein_name": "C-C motif chemokine 19",
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                "uniprot_canonical_ac": "Q9Y4X3-1",
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            },
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                "protein_name": "C-C motif chemokine 7",
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                "uniprot_canonical_ac": "Q9UBD3-1",
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                "protein_name": "Atypical chemokine receptor 4",
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                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P49682-1",
                "protein_name": "C-X-C chemokine receptor type 3",
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                "tax_name": "Human"
            },
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                "gene_name": "CXCL1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P47992-1",
                "protein_name": "Lymphotactin",
                "gene_name": "XCL1",
                "tax_name": "Human"
            },
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                "gene_name": "CCL25",
                "tax_name": "Human"
            },
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                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P51686-1",
                "protein_name": "C-C chemokine receptor type 9",
                "gene_name": "CCR9",
                "tax_name": "Human"
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            },
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                "uniprot_canonical_ac": "Q92583-1",
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                "uniprot_canonical_ac": "P32248-1",
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                "gene_name": "CCR7",
                "tax_name": "Human"
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                "uniprot_canonical_ac": "O00626-1",
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                "tax_name": "Human"
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                "protein_name": "Eotaxin",
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                "tax_name": "Human"
            },
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                "name": "Homo sapiens",
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        "abstract": "",
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    {
        "title": "Cloning and functional expression of a human eosinophil CC chemokine receptor.",
        "journal": "The Journal of biological chemistry",
        "date": "1995",
        "authors": "Combadiere C, Ahuja SK, Murphy PM",
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                "uniprot_canonical_ac": "P02775-1",
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            {
                "uniprot_canonical_ac": "P19876-1",
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        "title": "Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor.",
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    {
        "title": "Molecular cloning of a novel C or gamma type chemokine, SCM-1.",
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        "authors": "Yoshida T, Imai T, Kakizaki M, Nishimura M, Yoshie O",
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    {
        "title": "A new class of membrane-bound chemokine with a CX3C motif.",
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        "title": "Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion.",
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        "title": "The xeroderma pigmentosum group C protein complex XPC-HR23B plays an important role in the recruitment of transcription factor IIH to damaged DNA.",
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        "date": "2000",
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        "title": "SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting.",
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        "authors": "Rodriguez MS, Dargemont C, Hay RT",
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                "comment": "Little change in Tax-stimulated transactivation. No sumoylation. Greatly reduced Tax- or cytokine-stimulated transactivation and decrease in ubiquitination and degradation; when associated with R-22. Does not affect activation by FK506.",
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    {
        "title": "Novel functional interactions between nucleotide excision DNA repair proteins influencing the enzymatic activities of TFIIH, XPG, and ERCC1-XPF.",
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        "authors": "Winkler GS, Sugasawa K, Eker AP, de Laat WL, Hoeijmakers JH",
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    {
        "title": "Nucleolar delocalization of human topoisomerase I in response to topotecan correlates with sumoylation of the protein.",
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        "title": "The nucleoporin RanBP2 has SUMO1 E3 ligase activity.",
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    {
        "title": "The insulin-sensitive glucose transporter, GLUT4, interacts physically with Daxx. Two proteins with capacity to bind Ubc9 and conjugated to SUMO1.",
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        "date": "2002",
        "authors": "Lalioti VS, Vergarajauregui S, Pulido D, Sandoval IV",
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        "title": "Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover.",
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    {
        "title": "The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase.",
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        "date": "2002",
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                "gene_name": "NR2C1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P43354-1",
                "protein_name": "Nuclear receptor subfamily 4 group A member 2",
                "gene_name": "NR4A2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8C5D8-1",
                "protein_name": "E3 SUMO-protein ligase PIAS2",
                "gene_name": "Pias2",
                "tax_name": "Mouse"
            },
            {
                "uniprot_canonical_ac": "Q6AZ28-1",
                "protein_name": "E3 SUMO-protein ligase PIAS2",
                "gene_name": "Pias2",
                "tax_name": "Rat"
            },
            {
                "uniprot_canonical_ac": "P56524-1",
                "protein_name": "Histone deacetylase 4",
                "gene_name": "HDAC4",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P10275-1",
                "protein_name": "Androgen receptor",
                "gene_name": "AR",
                "tax_name": "Human"
            }
        ],
        "species": [
            {
                "name": "Homo sapiens",
                "taxid": 9606,
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P55854",
                        "url": "https://www.uniprot.org/uniprotkb/P55854"
                    }
                ],
                "common_name": "Human",
                "glygen_name": "Human",
                "reference_species": "Homo sapiens [9606]"
            }
        ],
        "mutagenesis": [
            {
                "start_pos": 372,
                "end_pos": 372,
                "sequence_org": "W",
                "sequence_mut": "A",
                "comment": "Loss of promotion of NCOA2 sumoylation. No effect on interaction with MSX1 or localization of either protein at the nuclear periphery.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "O88907",
                        "url": "https://www.uniprot.org/uniprotkb/O88907"
                    },
                    {
                        "database": "PubMed",
                        "id": "12077349",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12077349"
                    },
                    {
                        "database": "PubMed",
                        "id": "16600910",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/16600910"
                    }
                ],
                "uniprot_canonical_ac": "O88907-1"
            },
            {
                "start_pos": 324,
                "end_pos": 324,
                "sequence_org": "K",
                "sequence_mut": "R",
                "comment": "No effect on auto-sumoylation; when associated with R-326.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q6AZ28",
                        "url": "https://www.uniprot.org/uniprotkb/Q6AZ28"
                    },
                    {
                        "database": "PubMed",
                        "id": "12077349",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12077349"
                    }
                ],
                "uniprot_canonical_ac": "Q6AZ28-1"
            },
            {
                "start_pos": 326,
                "end_pos": 326,
                "sequence_org": "K",
                "sequence_mut": "R",
                "comment": "No effect on auto-sumoylation; when associated with R-324.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q6AZ28",
                        "url": "https://www.uniprot.org/uniprotkb/Q6AZ28"
                    },
                    {
                        "database": "PubMed",
                        "id": "12077349",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12077349"
                    }
                ],
                "uniprot_canonical_ac": "Q6AZ28-1"
            },
            {
                "start_pos": 379,
                "end_pos": 379,
                "sequence_org": "K",
                "sequence_mut": "R",
                "comment": "No effect on auto-sumoylation; when associated with R-380.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q6AZ28",
                        "url": "https://www.uniprot.org/uniprotkb/Q6AZ28"
                    },
                    {
                        "database": "PubMed",
                        "id": "12077349",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12077349"
                    }
                ],
                "uniprot_canonical_ac": "Q6AZ28-1"
            },
            {
                "start_pos": 380,
                "end_pos": 380,
                "sequence_org": "K",
                "sequence_mut": "R",
                "comment": "No effect on auto-sumoylation; when associated with R-379.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q6AZ28",
                        "url": "https://www.uniprot.org/uniprotkb/Q6AZ28"
                    },
                    {
                        "database": "PubMed",
                        "id": "12077349",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12077349"
                    }
                ],
                "uniprot_canonical_ac": "Q6AZ28-1"
            },
            {
                "start_pos": 383,
                "end_pos": 383,
                "sequence_org": "W",
                "sequence_mut": "A",
                "comment": "Loss of promotion of JUN sumoylation; no loss of interaction with SUMO1 and UBE2I.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q6AZ28",
                        "url": "https://www.uniprot.org/uniprotkb/Q6AZ28"
                    },
                    {
                        "database": "PubMed",
                        "id": "12077349",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12077349"
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                ],
                "uniprot_canonical_ac": "Q6AZ28-1"
            },
            {
                "start_pos": 390,
                "end_pos": 390,
                "sequence_org": "K",
                "sequence_mut": "R",
                "comment": "No effect on auto-sumoylation; when associated with R-391.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q6AZ28",
                        "url": "https://www.uniprot.org/uniprotkb/Q6AZ28"
                    },
                    {
                        "database": "PubMed",
                        "id": "12077349",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12077349"
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                ],
                "uniprot_canonical_ac": "Q6AZ28-1"
            },
            {
                "start_pos": 391,
                "end_pos": 391,
                "sequence_org": "K",
                "sequence_mut": "R",
                "comment": "No effect on auto-sumoylation; when associated with R-390.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q6AZ28",
                        "url": "https://www.uniprot.org/uniprotkb/Q6AZ28"
                    },
                    {
                        "database": "PubMed",
                        "id": "12077349",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12077349"
                    }
                ],
                "uniprot_canonical_ac": "Q6AZ28-1"
            },
            {
                "start_pos": 430,
                "end_pos": 430,
                "sequence_org": "K",
                "sequence_mut": "R",
                "comment": "No effect on auto-sumoylation; when associated with R-431.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q6AZ28",
                        "url": "https://www.uniprot.org/uniprotkb/Q6AZ28"
                    },
                    {
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                        "id": "12077349",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12077349"
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                ],
                "uniprot_canonical_ac": "Q6AZ28-1"
            },
            {
                "start_pos": 431,
                "end_pos": 431,
                "sequence_org": "K",
                "sequence_mut": "R",
                "comment": "No effect on auto-sumoylation; when associated with R-430.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q6AZ28",
                        "url": "https://www.uniprot.org/uniprotkb/Q6AZ28"
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                    {
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                        "id": "12077349",
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        "abstract": "",
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        ]
    },
    {
        "title": "p52 Mediates XPB function within the transcription/repair factor TFIIH.",
        "journal": "The Journal of biological chemistry",
        "date": "2002",
        "authors": "Jawhari A, Laine JP, Dubaele S, Lamour V, Poterszman A, Coin F, Moras D, Egly JM",
        "reference": {
            "type": "PubMed",
            "id": "12080057",
            "url": "https://pubmed.ncbi.nlm.nih.gov/12080057"
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        "referenced_glycans": [],
        "referenced_proteins": [
            {
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                "tax_name": "Human"
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                "protein_name": "Lysine-specific demethylase RAD23B",
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                "tax_name": "Human"
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                "protein_name": "General transcription factor IIH subunit 2",
                "gene_name": "GTF2H2C_2; GTF2H2C; GTF2H2",
                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "Q92759-1",
                "protein_name": "General transcription factor IIH subunit 4",
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                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "P19447-1",
                "protein_name": "General transcription and DNA repair factor IIH helicase/translocase subunit XPB",
                "gene_name": "ERCC3",
                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "P28715-1",
                "protein_name": "DNA excision repair protein ERCC-5",
                "gene_name": "ERCC5",
                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "Q9UGN5-1",
                "protein_name": "Poly [ADP-ribose] polymerase 2",
                "gene_name": "PARP2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q6ZYL4-1",
                "protein_name": "General transcription factor IIH subunit 5",
                "gene_name": "GTF2H5",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P35244-1",
                "protein_name": "Replication protein A 14 kDa subunit",
                "gene_name": "RPA3",
                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "P07992-1",
                "protein_name": "DNA excision repair protein ERCC-1",
                "gene_name": "ERCC1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q16531-1",
                "protein_name": "DNA damage-binding protein 1",
                "gene_name": "DDB1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P27694-1",
                "protein_name": "Replication protein A 70 kDa DNA-binding subunit",
                "gene_name": "RPA1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P41208-1",
                "protein_name": "Centrin-2",
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                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "Q01831-1",
                "protein_name": "DNA repair protein complementing XP-C cells",
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                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q86WJ1-1",
                "protein_name": "ATP-dependent chromatin remodeler CHD1L",
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                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "P32780-1",
                "protein_name": "General transcription factor IIH subunit 1",
                "gene_name": "GTF2H1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q13889-1",
                "protein_name": "General transcription factor IIH subunit 3",
                "gene_name": "GTF2H3",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q92466-1",
                "protein_name": "DNA damage-binding protein 2",
                "gene_name": "DDB2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P62877-1",
                "protein_name": "E3 ubiquitin-protein ligase RBX1",
                "gene_name": "RBX1",
                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "P18074-1",
                "protein_name": "General transcription and DNA repair factor IIH helicase subunit XPD",
                "gene_name": "ERCC2",
                "tax_name": "Human"
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            {
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        "title": "Small ubiquitin-related modifier-1 (SUMO-1) modification of the glucocorticoid receptor.",
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        "authors": "Tian S, Poukka H, Palvimo JJ, Janne OA",
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        "title": "Sumoylation of topoisomerase I is involved in its partitioning between nucleoli and nucleoplasm and its clearing from nucleoli in response to camptothecin.",
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    {
        "title": "Modification of Daxx by small ubiquitin-related modifier-1.",
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        "authors": "Jang MS, Ryu SW, Kim E",
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    {
        "title": "The polycomb protein Pc2 is a SUMO E3.",
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        "authors": "Kagey MH, Melhuish TA, Wotton D",
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    {
        "title": "A proteomic study of SUMO-2 target proteins.",
        "journal": "The Journal of biological chemistry",
        "date": "2004",
        "authors": "Vertegaal AC, Ogg SC, Jaffray E, Rodriguez MS, Hay RT, Andersen JS, Mann M, Lamond AI",
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        "title": "Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1.",
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        "title": "Sumoylation of internally initiated Sp3 isoforms regulates transcriptional repression via a Trichostatin A-insensitive mechanism.",
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