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        "title": "Identification of core alpha 1,3-fucosylated glycans and cloning of the requisite fucosyltransferase cDNA from Drosophila melanogaster. Potential basis of the neural anti-horseadish peroxidase epitope.",
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    {
        "title": "The PINK1/Parkin pathway regulates mitochondrial morphology.",
        "journal": "Proceedings of the National Academy of Sciences of the United States of America",
        "date": "2008-02-05",
        "authors": "Poole Angela C, Thomas Ruth E, Andrews Laurie A, McBride Heidi M, Whitworth Alexander J, Pallanck Leo J",
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        ],
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            {
                "name": "Drosophila melanogaster",
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                    {
                        "database": "UniProtKB",
                        "id": "Q0KHV6",
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                ],
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        ],
        "record_id": "pubmed.18230723",
        "abstract": "",
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        "section_stats": [
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            {
                "table_id": "glycosylation",
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                        "field": "n_linked_glycans",
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                        "field": "o_linked_glycans",
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                ],
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                        "field": "o_linked_glycan_sites",
                        "count": 0
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                    {
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                    {
                        "field": "o_linked_glycans",
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                ],
                "sort_fields": []
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        ]
    },
    {
        "title": "PINK1 controls mitochondrial localization of Parkin through direct phosphorylation.",
        "journal": "Biochemical and biophysical research communications",
        "date": "2008",
        "authors": "Kim Y, Park J, Kim S, Song S, Kwon SK, Lee SH, Kitada T, Kim JM, Chung J",
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            "id": "18957282",
            "url": "https://pubmed.ncbi.nlm.nih.gov/18957282"
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                "tax_name": "Fruit fly"
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            {
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                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9BXM7-1",
                "protein_name": "Serine/threonine-protein kinase PINK1, mitochondrial",
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                "tax_name": "Human"
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        ],
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            {
                "name": "Drosophila melanogaster",
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                ],
                "common_name": "Fruit fly",
                "glygen_name": "Fruit fly",
                "reference_species": "Drosophila melanogaster [7227]"
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        ],
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                "end_pos": 337,
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                "sequence_mut": "R",
                "comment": "Loss of kinase activity resulting in impaired mitochondrial integrity and function; when associated with A-479 and A-501.",
                "evidence": [
                    {
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                        "id": "Q0KHV6",
                        "url": "https://www.uniprot.org/uniprotkb/Q0KHV6"
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                    {
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                        "id": "18957282",
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                ],
                "uniprot_canonical_ac": "Q0KHV6-1"
            },
            {
                "start_pos": 479,
                "end_pos": 479,
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                "comment": "Loss of kinase activity and impaired recruitment of park to mitochondria. Loss of kinase activity resulting in impaired mitochondrial integrity and function; when associated with R-337 and A-501.",
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                        "database": "UniProtKB",
                        "id": "Q0KHV6",
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                    {
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                    {
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                        "id": "18957282",
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                    {
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                ],
                "uniprot_canonical_ac": "Q0KHV6-1"
            },
            {
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                "sequence_org": "D",
                "sequence_mut": "A",
                "comment": "Loss of kinase activity. Loss of kinase activity resulting in impaired mitochondrial integrity and function; when associated with R-337 and A-479.",
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                    {
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                        "id": "Q0KHV6",
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                    {
                        "database": "PubMed",
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                        "url": "https://pubmed.ncbi.nlm.nih.gov/30772175"
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                    {
                        "database": "PubMed",
                        "id": "22645651",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/22645651"
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                    {
                        "database": "PubMed",
                        "id": "18957282",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/18957282"
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                ],
                "uniprot_canonical_ac": "Q0KHV6-1"
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            {
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                "end_pos": 187,
                "sequence_org": "T",
                "sequence_mut": "A",
                "comment": "Reduced mitochondrial localization in the presence of Pink1. Reduced rescue of mitochondrial defects when expressed in null mutants.",
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                    {
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                        "id": "18957282",
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            {
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                "end_pos": 175,
                "sequence_org": "T",
                "sequence_mut": "A",
                "comment": "Loss of phosphorylation. Reduced mitochondrial localization; when associated with A-217.",
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                    {
                        "database": "UniProtKB",
                        "id": "O60260",
                        "url": "https://www.uniprot.org/uniprotkb/O60260"
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                    {
                        "database": "PubMed",
                        "id": "18957282",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/18957282"
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                ],
                "uniprot_canonical_ac": "O60260-1"
            },
            {
                "start_pos": 175,
                "end_pos": 175,
                "sequence_org": "T",
                "sequence_mut": "E",
                "comment": "Phosphomimetic mutant. Mostly localizes to the mitochondria; when associated with E-217.",
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                        "database": "PubMed",
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                        "url": "https://pubmed.ncbi.nlm.nih.gov/18957282"
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            {
                "start_pos": 217,
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                "sequence_org": "T",
                "sequence_mut": "A",
                "comment": "Loss of phosphorylation. Reduced mitochondrial localization; when associated with A-175.",
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                        "database": "UniProtKB",
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                "comment": "Phosphomimetic mutant. Mostly localizes to the mitochondria; when associated with E-175.",
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                        "database": "UniProtKB",
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                        "database": "UniProtKB",
                        "id": "O60260",
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    {
        "title": "PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila.",
        "journal": "PLoS genetics",
        "date": "2014",
        "authors": "Shiba-Fukushima K, Inoshita T, Hattori N, Imai Y",
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            "type": "PubMed",
            "id": "24901221",
            "url": "https://pubmed.ncbi.nlm.nih.gov/24901221"
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                "tax_name": "Fruit fly"
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            {
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                "protein_name": "E3 ubiquitin-protein ligase parkin",
                "gene_name": "park",
                "tax_name": "Fruit fly"
            }
        ],
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            {
                "name": "Drosophila melanogaster",
                "taxid": 7227,
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                        "id": "Q0KHV6",
                        "url": "https://www.uniprot.org/uniprotkb/Q0KHV6"
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                ],
                "common_name": "Fruit fly",
                "glygen_name": "Fruit fly",
                "reference_species": "Drosophila melanogaster [7227]"
            }
        ],
        "mutagenesis": [
            {
                "start_pos": 94,
                "end_pos": 94,
                "sequence_org": "S",
                "sequence_mut": "A",
                "comment": "Abolishes phosphorylation by Pink1 and reduces enzyme activity. Mitochondrial morphology and function is relatively normal however, expression in TH-neurons results in impaired flying ability, impaired dopamine release and an age-dependent loss of DA neurons, spherical clustering of mitochondria in DA neurons and disturbed mitochondrial transport. Able to rescue all mitochondrial and behavioral defects caused by the loss of Pink1. Partially rescues mitochondrial morphology and abnormal wing posture caused by loss of park. No effect on translocation to mitochondria.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q7KTX7",
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                    {
                        "database": "PubMed",
                        "id": "27906179",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/27906179"
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                    {
                        "database": "PubMed",
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                        "url": "https://pubmed.ncbi.nlm.nih.gov/24901221"
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                "sequence_mut": "G",
                "comment": "Phosphomimetic mutant with increased enzyme activity. Lethal when ubiquitously expressed. Constitutive phosphorylation results in impaired motor activity and fragmented mitochondria, likely due to reduced levels of the outer mitochondrial membrane proteins Marf and Miro. Expression in TH-neurons results in impaired flying ability, impaired dopamine release and substantial loss of DA neurons in very young adults (5-day old), single large mitochondria in each DA neuronal cell and loss of mitochondrial transport. Able to rescue reduced adult survival caused by loss of Pink1.",
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    },
    {
        "title": "PINK1-dependent phosphorylation of PINK1 and Parkin is essential for mitochondrial quality control.",
        "journal": "Cell death & disease",
        "date": "2016",
        "authors": "Zhuang N, Li L, Chen S, Wang T",
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            "id": "27906179",
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                "tax_name": "Fruit fly"
            },
            {
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                "protein_name": "E3 ubiquitin-protein ligase parkin",
                "gene_name": "park",
                "tax_name": "Fruit fly"
            }
        ],
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                "name": "Drosophila melanogaster",
                "taxid": 7227,
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                        "database": "UniProtKB",
                        "id": "Q0KHV6",
                        "url": "https://www.uniprot.org/uniprotkb/Q0KHV6"
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                ],
                "common_name": "Fruit fly",
                "glygen_name": "Fruit fly",
                "reference_species": "Drosophila melanogaster [7227]"
            }
        ],
        "mutagenesis": [
            {
                "start_pos": 346,
                "end_pos": 346,
                "sequence_org": "S",
                "sequence_mut": "A",
                "comment": "Abolishes activity and autophosphorylation. Fails to recruit park to mitochondria.",
                "evidence": [
                    {
                        "database": "UniProtKB",
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            },
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                "start_pos": 346,
                "end_pos": 346,
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                "comment": "Phosphomimetic mutant; no effect on activity and promotes translocation of park to mitochondria.",
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                "start_pos": 479,
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        "title": "Phosphorylation of MCAD selectively rescues PINK1 deficiencies in behavior and metabolism.",
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]
