{ "glytoucan_ac": "G84224TW", "number_monosaccharides": 2, "mass": 342.12, "mass_pme": 454.24, "fully_determined": "yes", "iupac": "beta-D-Galp-(1->4)-beta-D-Glcp-(1->", "wurcs": "WURCS=2.0/2,2,1/[a2122h-1b_1-5][a2112h-1b_1-5]/1-2/a4-b1", "glycoct": "RES 1b:b-dglc-HEX-1:5 2b:b-dgal-HEX-1:5 LIN 1:1o(4+1)2d", "inchi": "InChI=1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5+,6+,7-,8-,9-,10-,11-,12+/m1/s1", "glycam": "DGalpb1-4DGlcpb1-OH", "smiles_isomeric": "C([C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2O)O)O)CO)O)O)O)O", "inchi_key": { "key": "GUBGYTABKSRVRQ-DCSYEGIMSA-N", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/GUBGYTABKSRVRQ-DCSYEGIMSA-N" }, "crossref": [ { "id": "G84224TW", "database": "GlyTouCan", "url": "https://glytoucan.org/Structures/Glycans/G84224TW", "categories": [ "Glycomics" ] }, { "id": "GSD000116", "url": "https://wiki.glygen.org/Glycan_structure_dictionary#GSD000116", "database": "Glycan Structure Dictionary", "categories": [ "Ontology and Dictionary" ] } ], "publication": [ { "title": "Monoclonal antibody specific for lactosylceramide.", "journal": "The Journal of biological chemistry", "date": "1984", "authors": "Symington FW, Bernstein ID, Hakomori S", "evidence": [ { "database": "Glycan Motif", "id": "GGM.000064", "url": "https://glycomotif.glyomics.org/glycomotif/GGM.000064" } ], "reference": [ { "type": "PubMed", "id": "6585365", "url": "https://glygen.org/publication/PubMed/6585365" } ] }, { "title": "The repertoire of glycan determinants in the human glycome.", "journal": "Molecular bioSystems", "date": "2009", "authors": "Cummings RD", "evidence": [ { "database": "Glycan Motif", "id": "GGM.000064", "url": "https://glycomotif.glyomics.org/glycomotif/GGM.000064" } ], "reference": [ { "type": "PubMed", "id": "19756298", "url": "https://glygen.org/publication/PubMed/19756298" } ] }, { "title": "Structures Common to Different Glycans", "journal": "missing tag=JT", "date": "2015", "authors": "Stanley P, Cummings RD", "evidence": [ { "database": "Glycan Motif", "id": "GGM.000064", "url": "https://glycomotif.glyomics.org/glycomotif/GGM.000064" } ], "reference": [ { "type": "PubMed", "id": "28876849", "url": "https://glygen.org/publication/PubMed/28876849" } ] } ], "residues": [ { "id": "OC3", "name": "O-glycan_core_x-D-Glcx_C3", "attachedby": "rxn.Q8BYB9-1", "detachedby": "", "parentid": "0" }, { "id": "OC3", "name": "O-glycan_core_x-D-Glcx_C3", "attachedby": "rxn.Q8NBL1-1", "detachedby": "", "parentid": "0" }, { "id": "OC3", "name": "O-glycan_core_x-D-Glcx_C3", "attachedby": "rxn.Q9JHP7-1", "detachedby": "", "parentid": "0" }, { "id": "OC3", "name": "O-glycan_core_x-D-Glcx_C3", "attachedby": "rxn.Q6UW63-1", "detachedby": "", "parentid": "0" }, { "id": "OC3", "name": "O-glycan_core_x-D-Glcx_C3", "attachedby": "rxn.G5E897-1", "detachedby": "", "parentid": "0" }, { "id": "OC3", "name": "O-glycan_core_x-D-Glcx_C3", "attachedby": 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"parentid": "0" } ], "composition": [ { "name": "6-Deoxy-Hexose", "residue": "dhex", "count": 0, "cid": "840", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/840" }, { "name": "Hexose", "residue": "hex", "count": 2, "cid": "206", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/206" }, { "name": "N-Acetylhexosamine", "residue": "hexnac", "count": 0, "cid": "899", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/899" }, { "name": "Hexuronic Acid", "residue": "hexa", "count": 0, "cid": "610", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/610" }, { "name": "2-Amino-2-Deoxy-Hexose", "residue": "hexn", "count": 0, "cid": "739", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/739" }, { "name": "N-Acetyl-Neuraminic Acid", "residue": "neuac", "count": 0, "cid": "439197", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/439197" }, { "name": "N-Glycolyl-Neuraminic Acid", "residue": "neugc", "count": 0, "cid": "440001", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/440001" }, { "name": "Phosphate", "residue": "p", "count": 0, "cid": "1061", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/1061" }, { "name": "Pentose", "residue": "pent", "count": 0, "cid": "229", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/229" }, { "name": "Sulfate", "residue": "s", "count": 0, "cid": "1117", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/1117" }, { "name": "Other", "residue": "other", "count": 0 } ], "composition_expanded": [ { "name": "Alditol", "residue": "aldi", "count": 0 }, { "name": "6-Deoxy-Hexose", "residue": "dhex", "count": 0, "cid": "840", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/840" }, { "name": "6-Deoxy-Hexitol", "residue": "dhex+aldi", "count": 0 }, { "name": "L-Fucose", "residue": "fuc", "count": 0, "cid": "17106", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/17106" }, { "name": "L-Fucitol", "residue": "fuc+aldi", "count": 0, "cid": "445724", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/445724" }, { "name": "D-Galactose", "residue": "gal", "count": 1, "cid": "6036", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/6036" }, { "name": "D-Galactitol", "residue": "gal+aldi", "count": 0, "cid": "11850", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/11850" }, { "name": "N-Acetyl-D-galactosamine", "residue": "galnac", "count": 0, "cid": "35717", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/35717" }, { "name": "N-Acetylgalactosaminitol", "residue": "galnac+aldi", "count": 0, "cid": "165880", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/165880" }, { "name": "D-Galacturonic Acid", "residue": "gala", "count": 0, "cid": "439215", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/439215" }, { "name": "D-Glucose", "residue": "glc", "count": 1, "cid": "5793", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/5793" }, { "name": "D-Glucitol", "residue": "glc+aldi", "count": 0, "cid": "5780", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/5780" }, { "name": "D-Glucuronic acid", "residue": "glca", "count": 0, "cid": "94715", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/94715" }, { "name": "D-Glucosamine", "residue": "glcn", "count": 0, "cid": "439213", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/439213" }, { "name": "N-Acetyl-D-Glucosamine", "residue": "glcnac", "count": 0, "cid": "439174", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/439174" }, { "name": "N-Acetyl-D-glucosaminitol", "residue": "glcnac+aldi", "count": 0, "cid": "165206", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/165206" }, { "name": "Hexose", "residue": "hex", "count": 2, "cid": "206", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/206" }, { "name": "N-Acetylhexosamine", "residue": "hexnac", "count": 0, "cid": "899", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/899" }, { "name": "Hexuronic Acid", "residue": "hexa", "count": 0, "cid": "610", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/610" }, { "name": "2-Amino-2-Deoxy-Hexose", "residue": "hexn", "count": 0, "cid": "739", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/739" }, { "name": "Hexitol", "residue": "hex+aldi", "count": 0, "cid": "453", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/453" }, { "name": "N-Acetylhexosaminitol", "residue": "hexnac+aldi", "count": 0 }, { "name": "L-Iduronic acid", "residue": "idoa", "count": 0, "cid": "441039", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/441039" }, { "name": "D-Mannose", "residue": "man", "count": 0, "cid": "18950", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/18950" }, { "name": "D-Mannitol", "residue": "man+aldi", "count": 0, "cid": "6251", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/6251" }, { "name": "N-Acetyl-D-mannosamine", "residue": "mannac", "count": 0, "cid": "439281", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/439281" }, { "name": "Methyl", "residue": "me", "count": 0 }, { "name": "N-Acetyl-Neuraminic Acid", "residue": "neuac", "count": 0, "cid": "439197", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/439197" }, { "name": "N-Glycolyl-Neuraminic Acid", "residue": "neugc", "count": 0, "cid": "440001", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/440001" }, { "name": "Phosphate", "residue": "p", "count": 0, "cid": "1061", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/1061" }, { "name": "Pentose", "residue": "pent", "count": 0, "cid": "229", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/229" }, { "name": "Sulfate", "residue": "s", "count": 0, "cid": "1117", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/1117" }, { "name": "Sialic acid", "residue": "sia", "count": 0 }, { "name": "Other", "residue": "other", "count": 0 }, { "name": "Floating substituent", "residue": "x", "count": 0 }, { "name": "D-Xylose", "residue": "xyl", "count": 0, "cid": "135191", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/135191" }, { "name": "Ketodeoxynononic acid", "residue": "kdn", "count": 0, "cid": "13991616", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/13991616" } ], "glycans": [ { "glytoucan_ac": "G04093XE", "url": "https://glytoucan.org/Structures/Glycans/G04093XE" }, { "glytoucan_ac": "G10794OA", "url": "https://glytoucan.org/Structures/Glycans/G10794OA" }, { "glytoucan_ac": "G15541SE", "url": "https://glytoucan.org/Structures/Glycans/G15541SE" }, { "glytoucan_ac": "G33765XW", "url": "https://glytoucan.org/Structures/Glycans/G33765XW" }, { "glytoucan_ac": "G45323ZF", "url": "https://glytoucan.org/Structures/Glycans/G45323ZF" }, { "glytoucan_ac": "G64014BL", "url": "https://glytoucan.org/Structures/Glycans/G64014BL" }, { "glytoucan_ac": "G72163XD", "url": "https://glytoucan.org/Structures/Glycans/G72163XD" }, { "glytoucan_ac": "G74621DY", "url": "https://glytoucan.org/Structures/Glycans/G74621DY" }, { "glytoucan_ac": "G78508BQ", "url": "https://glytoucan.org/Structures/Glycans/G78508BQ" }, { "glytoucan_ac": "G79249LD", "url": "https://glytoucan.org/Structures/Glycans/G79249LD" }, { "glytoucan_ac": "G84224TW", "url": "https://glytoucan.org/Structures/Glycans/G84224TW" } ], "subsumption": [ { "id": "G04093XE", "type": "Saccharide" }, { "id": "G04473OS", "type": "Saccharide" }, { "id": "G06348JD", "type": "Saccharide" }, { "id": "G07133YY", "type": "BaseComposition" }, { "id": "G10794OA", "type": "Saccharide" }, { "id": "G12365LP", "type": "Composition" }, { "id": "G15541SE", "type": "Saccharide" }, { "id": "G24870GJ", "type": "Saccharide" }, { "id": "G33588RF", "type": "Topology" }, { "id": "G33765XW", "type": "Saccharide" }, { "id": "G43850JD", "type": "Composition" }, { "id": "G45116DB", "type": "Composition" }, { "id": "G45323ZF", "type": "Topology" }, { "id": "G45916AH", "type": "Saccharide" }, { "id": "G46263LW", "type": "Topology" }, { "id": "G46621QD", "type": "Composition" }, { "id": "G57355GZ", "type": "Topology" }, { "id": "G58408UN", "type": "Composition" }, { "id": "G64014BL", "type": "Topology" }, { "id": "G64081IB", "type": "Saccharide" }, { "id": "G72163XD", "type": "Saccharide" }, { "id": "G74621DY", "type": "Saccharide" }, { "id": "G75958RL", "type": "Topology" }, { "id": "G78508BQ", "type": "Topology" }, { "id": "G79249LD", "type": "Saccharide" }, { "id": "G90627TW", "type": "BaseComposition" }, { "id": "G93573CR", "type": "Saccharide" }, { "id": "G93775QP", "type": "Topology" }, { "id": "G95010WC", "type": "Topology" }, { "id": "G95251JJ", "type": "Topology" }, { "id": "G99425TA", "type": "Composition" } ], "names": [ { "name": "Lactosylceramide", "domain": "Semantic Name" }, { "name": "Lactosylceramide", "domain": "motifname" } ], "synonym": [], "keywords": [ { "label": "Glycolipid", "url": "https://glycomotif.glyomics.org/glycomotif/Glycolipid" } ], "reducing_end": "true", "aglycon": "Cer", "alignment_method": "Whole-Glycan", "dictionary": { "term": "Lactosylceramide", "term_in_sentence": "In the 1970s, a neutral glycosphingolipid lactosylceramide (LacCer) was found to bind specifically to several kinds of microorganisms.[PMID:30175814]", "publication": "30175814|26900161|30502090|29624959|28444900|25408340|31801289|29099167|25595946|32592089|27729551|24658420|25216636|25638276|9499377|17986153|8143857|23801329|18077097|32708181|15346887|19015977|18393821|25279740|21057870|11915327|25212460|23882130|11915329|8195125|8808768|3396945|22128256|6733104|24968752|32518749|30688114|7666005|8200356|24718572|6193809|25781947|12383912|26086247|30606995|12419803", "definition": "Glycosphingolipids which contain as their polar head group a lactose moiety bound in glycosidic linkage to the hydroxyl group of ceramide. Their accumulation in tissue, due to a defect in lactosylceramide beta-galactosidase, is the cause of lactosylceramidosis.[MeSH:D007790]", "term_xref": "GTC:G84224TW|MeSH:D007790|GlycoMotif:GGM.000064|GlycoEpitope:EP0078|SugarBind_Ligand:3", "synonymns": [ "LacCer", "Lc2", "CDH" ], "function": "mammalian cell receptors for Neisseria gonorrhoeae recognized by Helicobacter pylori[GlycoEpitope:EP0078]", "disease_associations": "chronic gastritis[GlycoEpitope:EP0078,SugarBind_Ligand:3]|duodenal ulcers[GlycoEpitope:EP0078]|gastric adenocarcinoma[GlycoEpitope:EP0078,SugarBind_Ligand:3]|gastric ulcers[GlycoEpitope:EP0078]|Pleuropneumonia[SugarBind_Ligand:3]|Porcine fibrinohemorrhagic necrotizing pleuropneumonia[SugarBind_Ligand:3]|Actinomycosis[SugarBind_Ligand:3]|Pertussis[SugarBind_Ligand:3]|Candidiasis[SugarBind_Ligand:3]|Cryptococcosis[SugarBind_Ligand:3]|Hemorrhagic colitis[SugarBind_Ligand:3]|Peptic ulcers[SugarBind_Ligand:3]|Histoplasmosis[SugarBind_Ligand:3]|Pharyngitis[SugarBind_Ligand:3]|Tracheobronchitis[SugarBind_Ligand:3]|Gonorrhea[SugarBind_Ligand:3]|Sporotrichosis[SugarBind_Ligand:3]|Plague[SugarBind_Ligand:3]|Diarrhea[SugarBind_Ligand:3]", "wikipedia": "", "essentials_of_glycobiology": "Chapter 17", "evidence": [ { "id": "GSD000116", "url": "https://wiki.glygen.org/Glycan_structure_dictionary#GSD000116", "database": "Glycan Structure Dictionary" } ] }, "biomarkers": [], "motif_ac": "GGM.000064", "section_stats": [ { "table_id": "results", "table_stats": [ { "field": "total", "count": 11 } ], "sort_fields": [ "glytoucan_ac", "url" ] } ] }