[ { "uniprot_canonical_ac": "P52172-1", "uniprot_id": [ { "id": "SRP_DROME", "url": "https://www.uniprot.org/uniprot/P52172", "type": "external" } ], "mass": 134158.0, "length": 1264, "protein_name": "Box A-binding factor", "gene_name": "srp", "organism": "Fruit fly", "refseq_name": "serpent, isoform D", "refseq_ac": [ { "id": "NP_001027190", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027190", "type": "external" } ], "gene_names_uniprotkb": "srp; A7.1; ABF; Abf; CG3992; DmGATAb; Dmel\\CG3992; Dmel_CG3992; GATAb; GATA; SRP; Srp; abf; dGATAb; l(3)01549; l(3)89B2; l(3)neo45; spt; srpD", "gene_names_refseq": "A7.1; ABF; Abf; CG3992; DmGATAb; Dmel\\CG3992; GATAb; GATA; SRP; Srp; abf; dGATAb; l(3)01549; l(3)89B2; l(3)neo45; spt; srpD; srp", "protein_names_uniprotkb": "Box A-binding factor; ABF; GATA-binding factor B; Protein serpent; Transcription factor GATA-B; dGATA-B", "protein_names_refseq": "A-box-binding factor; CG3992-PD; serpent, isoform D; serpentD; serpent; srp-PD", "tax_id": 7227, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); congenital nonspherocytic hemolytic anemia 9 (Disease Ontology:DOID:0051008); transient myeloproliferative syndrome (Disease Ontology:DOID:0060888); myeloid leukemia associated with Down Syndrome (Disease Ontology:DOID:0080798); X-linked thrombocytopenia with beta-thalassemia (Disease Ontology:DOID:0111767); X-linked dyserythropoietic anemia (Disease Ontology:DOID:0112156); beta thalassemia (Disease Ontology:DOID:12241); lung cancer (Disease Ontology:DOID:1324); major depressive disorder (Disease Ontology:DOID:1470); thrombocytopenia (Disease Ontology:DOID:1588); depressive disorder (Disease Ontology:DOID:1596); colon adenocarcinoma (Disease Ontology:DOID:234); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); myelofibrosis (Disease Ontology:DOID:4971); polycythemia (Disease Ontology:DOID:8432); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dme:Dmel_CG3992); (R-DME-5689880); (R-DME-8939236); (R-DME-9018519); (R-DME-983231)", "pathway_count": 5, "publication_count": 16, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;34860835;8187633;9012522", "class_list": "", "function": "May function as a transcriptional activator protein and may play a key role in the organogenesis of the fat body. Binds a sequence element (5'-[TA]GATAA-3') found in the larval promoters of all known alcohol dehydrogenase (ADH) genes. Acts as a homeotic gene downstream of the terminal gap gene HKB to promote morphogenesis and differentiation of anterior and posterior midgut. Together with transcriptional cofactor Bfc directly binds the promoter of phagocytic receptor crq/croquemort to upregulate its expression and stimulate efferocytosis in response to apoptotic cells, including during embryogenesis (PubMed:34860835)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6NMW1;Q7K0H5;Q8INC6;Q94884;Q9VF01", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0001710 mesodermal cell fate commitment;GO:0035162 embryonic hemopoiesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P52172-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VHA0-1", "uniprot_id": [ { "id": "SCM_DROME", "url": "https://www.uniprot.org/uniprot/Q9VHA0", "type": "external" } ], "mass": 93551.0, "length": 877, "protein_name": "Polycomb protein Scm", "gene_name": "Scm", "organism": "Fruit fly", "refseq_name": "Sex comb on midleg, isoform B", "refseq_ac": [ { "id": "NP_001247006", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001247006", "type": "external" } ], "gene_names_uniprotkb": "Scm; CG9495; Dmel\\CG9495; Dmel_CG9495; SCM; Su(z)302; l(3)85Ef; scm", "gene_names_refseq": "CG9495; Dmel\\CG9495; SCM; Scm; Su(z)302; l(3)85Ef; scm", "protein_names_uniprotkb": "Polycomb protein Scm; Sex comb on midleg protein", "protein_names_refseq": "CG9495-PB; Scm-PB; Sex comb on midleg, isoform B; Sex comb on the midleg; Sex combs on midlegs; Sex combs on midleg; sex comb on midleg", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9495); (R-DME-2559580); (R-DME-3108214); (R-DME-3899300); (R-DME-4570464); (R-DME-8939243); (R-DME-8943724)", "pathway_count": 7, "publication_count": 18, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;12771214;15280237;15905166;16110336;17569856;17569867;18327897;25589440;26109356;26109357;8625848;9343432", "class_list": "", "function": "Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q24191", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042393 histone binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005700 polytene chromosome", "go_biological_process": "GO:0048749 compound eye development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007409 axonogenesis;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9VHA0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8MLY8-1", "uniprot_id": [ { "id": "RS8_DROME", "url": "https://www.uniprot.org/uniprot/Q8MLY8", "type": "external" } ], "mass": 23759.0, "length": 208, "protein_name": "Small ribosomal subunit protein eS8", "gene_name": "RpS8", "organism": "Fruit fly", "refseq_name": "ribosomal protein S8, isoform E", "refseq_ac": [ { "id": "NP_001247362", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001247362", "type": "external" } ], "gene_names_uniprotkb": "RpS8; BcDNA:RH06886; BcDNA:SD17528; CG7808; Dmel\\CG7808; Dmel_CG7808; RPS8; Rp S8; Rps8; S8e; S8; anon-EST:Liang-1.56; anon-EST:fe1A2; chr3R:25688477..25688608; clone 1.56", "gene_names_refseq": "BcDNA:RH06886; BcDNA:SD17528; CG7808; Dmel\\CG7808; RPS8; Rp S8; RpS8; Rps8; S8e; S8; anon-EST:Liang-1.56; anon-EST:fe1A2; chr3R:25688477..25688608; clone 1.56", "protein_names_uniprotkb": "Small ribosomal subunit protein eS8; 40S ribosomal protein S8", "protein_names_refseq": "CG7808-PE; RpS8-PE; anon-fast-evolving-1A2; ribosomal protein S8, isoform E", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7808); (R-DME-156827); (R-DME-1799339); (R-DME-6791226); (R-DME-72649); (R-DME-72689); (R-DME-72695); (R-DME-72702); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 13, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;23636399;25589440;26109356;26109357", "class_list": "", "function": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VAF1", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0016020 membrane;GO:0022626 cytosolic ribosome;GO:0032040 small-subunit processome;GO:0022627 cytosolic small ribosomal subunit;GO:0005840 ribosome", "go_biological_process": "GO:0006412 translation;GO:0002181 cytoplasmic translation;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8MLY8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IH24-1", "uniprot_id": [ { "id": "MED31_DROME", "url": "https://www.uniprot.org/uniprot/Q8IH24", "type": "external" } ], "mass": 23531.0, "length": 204, "protein_name": "Mediator of RNA polymerase II transcription subunit 31", "gene_name": "MED31", "organism": "Fruit fly", "refseq_name": "mediator complex subunit 31, isoform C", "refseq_ac": [ { "id": "NP_001246908", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246908", "type": "external" } ], "gene_names_uniprotkb": "MED31; BcDNA:GM28912; CG1057; Dmel\\CG1057; Dmel_CG1057; Med31; Trap18; dSOH1; dTRAP18; med31; p36", "gene_names_refseq": "BcDNA:GM28912; CG1057; Dmel\\CG1057; MED31; Med31; Trap18; dSOH1; dTRAP18; med31; p36", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 31; Mediator complex subunit 31; Protein SOH1; dSOH1", "protein_names_refseq": "CG1057-PC; MED31-PC; mediator complex subunit 31, isoform C; mediator", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1057); (R-DME-9841922)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;11259581;12537568;12537569;12537572;12537573;12537574;16110336;16751183;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V2E4;Q9VN40", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0008595 anterior/posterior axis specification, embryo;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8IH24-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V9S7-1", "uniprot_id": [ { "id": "SYDE_DROME", "url": "https://www.uniprot.org/uniprot/Q9V9S7", "type": "external" } ], "mass": 198298.0, "length": 1866, "protein_name": "Rho GTPase-activating protein 100F", "gene_name": "RhoGAP100F", "organism": "Fruit fly", "refseq_name": "Rho GTPase activating protein at 100F, isoform B", "refseq_ac": [ { "id": "NP_001163785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163785", "type": "external" } ], "gene_names_uniprotkb": "RhoGAP100F; 1976; CG1976; DSyd-1; DSyd1; DSyd; Dmel\\CG1976; Dmel_CG1976; Dsyd-1; RHOGAP100F; Syd-1; Syd1; dSyd-1; dsyd-1; syd-1; syd1", "gene_names_refseq": "1976; CG1976; DSyd-1; DSyd1; DSyd; Dmel\\CG1976; Dsyd-1; RHOGAP100F; RhoGAP100F; Syd-1; Syd1; dSyd-1; dsyd-1; syd-1; syd1", "protein_names_uniprotkb": "Rho GTPase-activating protein 100F; Protein syd-1 homolog; RhoGAP-100F; Synapse defective protein 1 homolog", "protein_names_refseq": "CG1976-PB; Rho GTPase activating protein at 100F, isoform B; RhoGAP100F-PB; synapse defective-1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1976); (R-DME-9013148); (R-DME-9013149); (R-DME-9013406); (R-DME-9013409); (R-DME-9013423); (R-DME-9035034)", "pathway_count": 7, "publication_count": 16, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;22864612;25589440;26109356;26109357;33925313;40245499", "class_list": "", "function": "GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity). Promotes the anchoring of Liprin-alpha clusters at synapses (PubMed:22864612). Recruits and keeps Nrx-1 levels high in active zones in the presynapse opposite the postsynaptic region (PubMed:22864612)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "C3KGQ2;E1JJ30;E1JJ31;Q8SWW5", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0098831 presynaptic active zone cytoplasmic component;GO:0031594 neuromuscular junction;GO:0048786 presynaptic active zone;GO:0097060 synaptic membrane", "go_biological_process": "GO:0048789 cytoskeletal matrix organization at active zone;GO:0048790 maintenance of presynaptic active zone structure;GO:1990709 presynaptic active zone organization;GO:0016477 cell migration;GO:0007266 Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q9V9S7-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000100000000000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7K0E3-1", "uniprot_id": [ { "id": "MOB4_DROME", "url": "https://www.uniprot.org/uniprot/Q7K0E3", "type": "external" } ], "mass": 25747.0, "length": 223, "protein_name": "MOB kinase activator-like 4", "gene_name": "Mob4", "organism": "Fruit fly", "refseq_name": "MOB kinase activator 4, isoform A", "refseq_ac": [ { "id": "NP_610229", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610229", "type": "external" } ], "gene_names_uniprotkb": "Mob4; CG3403; DMob4; Dmel\\CG3403; Dmel_CG3403; Dmob4; MOB4; dMob4; dmob4", "gene_names_refseq": "CG3403; DMob4; Dmel\\CG3403; Dmob4; MOB4; Mob4; dMob4; dmob4", "protein_names_uniprotkb": "MOB kinase activator-like 4; Dmob4; Mob as tumor suppressor protein 4; Mps one binder kinase activator-like 4", "protein_names_refseq": "CG3403-PA; MOB kinase activator 4, isoform A; Mob4-PA; Mps one binder kinase activator-like 4", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3403)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;15975907;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043195 terminal bouton;GO:0090443 FAR/SIN/STRIPAK complex", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0031670 cellular response to nutrient;GO:0035330 regulation of hippo signaling;GO:0008088 axo-dendritic transport;GO:0048812 neuron projection morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q7K0E3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24595-1", "uniprot_id": [ { "id": "XPC_DROME", "url": "https://www.uniprot.org/uniprot/Q24595", "type": "external" } ], "mass": 144224.0, "length": 1293, "protein_name": "DNA repair protein complementing XP-C cells homolog", "gene_name": "Xpc", "organism": "Fruit fly", "refseq_name": "xeroderma pigmentosum, complementation group C, isoform A", "refseq_ac": [ { "id": "NP_476861", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476861", "type": "external" } ], "gene_names_uniprotkb": "Xpc; CG8153; DhR4; DhXPC; DmXPC; Dmel\\CG8153; Dmel_CG8153; Mus 210; Mus210; XPC[DM]; XPC; Xpcc; mus(2)201G1; mus(2)201[GI]; mus(2)201; mus201[G1]; mus210; mus212", "gene_names_refseq": "CG8153; DhR4; DhXPC; DmXPC; Dmel\\CG8153; Mus 210; Mus210; XPC[DM]; XPC; Xpcc; Xpc; mus(2)201G1; mus(2)201[GI]; mus(2)201; mus201[G1]; mus210; mus212", "protein_names_uniprotkb": "DNA repair protein complementing XP-C cells homolog; Mutagen-sensitive 209 protein; XPCDM; Xeroderma pigmentosum group C-complementing protein homolog", "protein_names_refseq": "CG8153-PA; Xpc-PA; mus210; mutagen-sensitive 210; xeroderma pigmentosum group C complementing factor; xeroderma pigmentosum group C-like; xeroderma pigmentosum, complementation group C, isoform A", "tax_id": 7227, "disease": "xeroderma pigmentosum (Disease Ontology:DOID:0050427); xeroderma pigmentosum group C (Disease Ontology:DOID:0110844); lung cancer (Disease Ontology:DOID:1324); pancreatic cancer (Disease Ontology:DOID:1793); serous cystadenocarcinoma (Disease Ontology:DOID:3114)", "pathway": " (dme:Dmel_CG8153); (R-DME-5696394); (R-DME-5696395)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10731132;10812334;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;8127661", "class_list": "", "function": "Involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes (By similarity)., [UniProtKB]; Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7KJI5;Q8MLA1;Q8MLA2;Q9U3Z0;Q9U3Z1;Q9V7A8", "ec_number_list": [], "go_molecular_function": "GO:0003684 damaged DNA binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0071942 XPC complex;GO:0000111 nucleotide-excision repair factor 2 complex", "go_biological_process": "GO:0006298 mismatch repair;GO:0006289 nucleotide-excision repair;GO:0010777 meiotic mismatch repair involved in reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q24595-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q94913-1", "uniprot_id": [ { "id": "REG5_DROME", "url": "https://www.uniprot.org/uniprot/Q94913", "type": "external" } ], "mass": 31601.0, "length": 288, "protein_name": "Rhythmically expressed gene 5 protein", "gene_name": "Reg-5", "organism": "Fruit fly", "refseq_name": "rhythmically expressed gene 5, isoform B", "refseq_ac": [ { "id": "NP_001246504", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246504", "type": "external" } ], "gene_names_uniprotkb": "Reg-5; CG2928; DREG-5; Dmel\\CG2928; Dmel_CG2928; Dreg-5; Dreg5; Dreg; dreg-5; reg-5", "gene_names_refseq": "CG2928; DREG-5; Dmel\\CG2928; Dreg-5; Dreg5; Dreg; Reg-5; dreg-5; reg-5", "protein_names_uniprotkb": "Rhythmically expressed gene 5 protein; dReg-5", "protein_names_refseq": "CG2928-PB; Reg-5-PB; drosophila rhythmically expressed gene 5; rhythmically expressed gene 5, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2928)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8612586", "class_list": "", "function": "Involved in the generation of biological rhythms (Potential). In the head, oscillates in abundance with a daily peak during early night, even under constant darkness. Oscillation is dependent on period (per) function., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q95RZ9;Q9W104", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0048511 rhythmic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q94913-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52034-1", "uniprot_id": [ { "id": "PFKA_DROME", "url": "https://www.uniprot.org/uniprot/P52034", "type": "external" } ], "mass": 86648.0, "length": 788, "protein_name": "ATP-dependent 6-phosphofructokinase", "gene_name": "Pfk", "organism": "Fruit fly", "refseq_name": "phosphofructokinase, isoform A", "refseq_ac": [ { "id": "NP_523676", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523676", "type": "external" } ], "gene_names_uniprotkb": "Pfk; BcDNA.GH12192; BcDNA:GH12192; CG4001; Dmel\\CG4001; Dmel_CG4001; PFK1; PFK; l(2)06339; pfk", "gene_names_refseq": "BcDNA.GH12192; BcDNA:GH12192; CG4001; Dmel\\CG4001; PFK1; PFK; Pfk; l(2)06339; pfk", "protein_names_uniprotkb": "ATP-dependent 6-phosphofructokinase; 2.7.1.11; ATP-PFK; Phosphofructokinase; Phosphohexokinase", "protein_names_refseq": "6-phosphofructokinase; CG4001-PA; Pfk-PA; phosphofructokinase 1; phosphofructokinase, isoform A", "tax_id": 7227, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); glycogen storage disease VII (Disease Ontology:DOID:11721); glycogen storage disease (Disease Ontology:DOID:2747)", "pathway": " (dme:Dmel_CG4001); (R-DME-6798695); (R-DME-70171)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10731132;10731138;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;2935142;7929140", "class_list": "", "function": "Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis., [UniProtKB, HAMAP, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IH94;Q8MKV4;Q9V5G7;Q9Y100", "ec_number_list": [ { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "5.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.-", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "5.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "1.11.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.-", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" } ], "go_molecular_function": "GO:0070095 fructose-6-phosphate binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003872 6-phosphofructokinase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005945 6-phosphofructokinase complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0042593 glucose homeostasis;GO:0006096 glycolytic process;GO:0030388 fructose 1,6-bisphosphate metabolic process;GO:0061621 canonical glycolysis;GO:0009744 response to sucrose", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P52034-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VCX1-1", "uniprot_id": [ { "id": "RGS_DROME", "url": "https://www.uniprot.org/uniprot/Q9VCX1", "type": "external" } ], "mass": 167282.0, "length": 1541, "protein_name": "Regulator of G protein signaling loco", "gene_name": "loco", "organism": "Fruit fly", "refseq_name": "locomotion defects, isoform D", "refseq_ac": [ { "id": "NP_732773", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_732773", "type": "external" } ], "gene_names_uniprotkb": "loco; CG17229; CG5248; Dmel\\CG5248; Dmel_CG5248; LOCO; Loco; dLoco", "gene_names_refseq": "CG17229; CG5248; Dmel\\CG5248; LOCO; Loco; dLoco; loco", "protein_names_uniprotkb": "Regulator of G protein signaling loco; Locomotion defects protein; Loco; RGS", "protein_names_refseq": "CG5248-PD; loco-PD; locomotion defects, isoform D; locomotion defects", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5248); (R-DME-418594)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10079238;10731132;11731228;12537568;12537569;12537572;12537573;12537574;15937221;16110336;16213218;17569856;17569867;21255223;25589440;26109356;26109357", "class_list": "", "function": "Acts as a regulator of G protein signaling (RGS). Modulates G protein alpha subunits nucleotide exchange and hydrolysis activities by functioning either as a GTPase-activating protein (GAP), thereby driving G protein alpha subunits into their inactive GDP-bound form, or as a GDP-dissociation inhibitor (GDI). Confers GDI and GAP activities on G(i) alpha subunit Galphai. Confers GAP activity on G(o)-alpha subunit Galphao and G(i) alpha subunit Galphai. Involved in the dorsal-ventral axis formation of the egg. Acts as a G protein signaling for glial cell differentiation during embryogenesis; Galphai, Galphao and the G protein-coupled receptor, moody, are required in the surface glia to achieve effective insulation of the nerve cord. May be essential for nurse cell dumping during oogenesis. Required in neuroblast asymmetrical cell division. Plays a role in stress resistance and life span control., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9NGQ0;Q9UB06;Q9XYX8", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0001965 G-protein alpha-subunit binding;GO:0005092 GDP-dissociation inhibitor activity", "go_cellular_component": "GO:0045179 apical cortex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0009786 regulation of asymmetric cell division;GO:0000578 embryonic axis specification;GO:0006979 response to oxidative stress;GO:0007186 G protein-coupled receptor signaling pathway;GO:0042594 response to starvation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9VCX1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VCA9-1", "uniprot_id": [ { "id": "SPCS3_DROME", "url": "https://www.uniprot.org/uniprot/Q9VCA9", "type": "external" } ], "mass": 20304.0, "length": 179, "protein_name": "Signal peptidase complex subunit 3", "gene_name": "Spase22-23", "organism": "Fruit fly", "refseq_name": "spase 22/23-subunit, isoform B", "refseq_ac": [ { "id": "NP_001247279", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001247279", "type": "external" } ], "gene_names_uniprotkb": "Spase22-23; 23; CG5677; Dmel\\CG5677; Dmel_CG5677", "gene_names_refseq": "CG5677; Dmel\\CG5677; Spase22-23; Spase22/23", "protein_names_uniprotkb": "Signal peptidase complex subunit 3; Microsomal signal peptidase 22 kDa subunit; SPC22; SPase 22 kDa subunit", "protein_names_refseq": "CG5677-PB; Spase22-23-PB; Spase22/23-subunit; spase 22/23-subunit, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5677)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15901661;16110336;17569856;17569867;25589440;26109356;26109357;27383988", "class_list": "", "function": "(Microbial infection) Plays an important role in infection by flaviviruses such as West Nile virus and Dengue virus type 2., [UniProtKB, PubMed]; Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005787 signal peptidase complex", "go_biological_process": "GO:0045047 protein targeting to ER;GO:0006465 signal peptide processing", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VCA9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83098-1", "uniprot_id": [ { "id": "STRA_DROME", "url": "https://www.uniprot.org/uniprot/P83098", "type": "external" } ], "mass": 39895.0, "length": 346, "protein_name": "STE20-related kinase adapter protein stlk", "gene_name": "Stlk", "organism": "Fruit fly", "refseq_name": "Ste20-like kinase, isoform A", "refseq_ac": [ { "id": "NP_001036442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036442", "type": "external" } ], "gene_names_uniprotkb": "Stlk; BcDNA:LD05623; CG40293; DmSTRADalpha; Dmel\\CG40293; Dmel_CG40293; LD05623; STRADalpha; stlk", "gene_names_refseq": "BcDNA:LD05623; CG40293; DmSTRADalpha; Dmel\\CG40293; LD05623; STRADalpha; Stlk; stlk", "protein_names_uniprotkb": "STE20-related kinase adapter protein stlk; STRAD; Ste20-like kinase", "protein_names_refseq": "CG40293-PA; Ste20-like kinase, isoform A; Stlk-PA", "tax_id": 7227, "disease": "polyhydramnios, megalencephaly, and symptomatic epilepsy (Disease Ontology:DOID:0070511); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dme:Dmel_CG40293)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7PLH7;Q8T0F8", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P83098-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KNS3-1", "uniprot_id": [ { "id": "LIS1_DROME", "url": "https://www.uniprot.org/uniprot/Q7KNS3", "type": "external" } ], "mass": 46460.0, "length": 411, "protein_name": "Lissencephaly-1 homolog", "gene_name": "Lis-1", "organism": "Fruit fly", "refseq_name": "Lissencephaly-1, isoform G", "refseq_ac": [ { "id": "NP_001246361", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246361", "type": "external" } ], "gene_names_uniprotkb": "Lis-1; CG8440; D-Lis1; DLIS-1; DLIS1; DLis-1; DLis1; Dlis-1; Dlis1; DmLIS1; Dmel\\CG8440; Dmel_CG8440; LIS-1; Lis 1; Lis1; Lis; dLis1; l(2)k13209; l(2R)W8; lis-1; lis1; n(2)k11702", "gene_names_refseq": "CG8440; D-Lis1; DLIS-1; DLIS1; DLis-1; DLis1; Dlis-1; Dlis1; DmLIS1; Dmel\\CG8440; LIS-1; Lis 1; Lis-1; Lis1; Lis; dLis1; l(2)k13209; l(2R)W8; lis-1; lis1; n(2)k11702", "protein_names_uniprotkb": "Lissencephaly-1 homolog; DLis-1; Dlis1; Lissencephaly1", "protein_names_refseq": "CG8440-PG; Lis-1-PG; Lissencephaly-1, isoform G; Paf-AHbeta; lissencephaly-1; platelet-activating factor acetylhydrolase Ib beta-subunit homolog", "tax_id": 7227, "disease": "lissencephaly (Disease Ontology:DOID:0050453); Miller-Dieker lissencephaly syndrome (Disease Ontology:DOID:0060469); lissencephaly 1 (Disease Ontology:DOID:0112237); status epilepticus (Disease Ontology:DOID:1824); schizophrenia (Disease Ontology:DOID:5419); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dme:Dmel_CG8440); (R-DME-1169091); (R-DME-202424); (R-DME-2565942); (R-DME-2871837); (R-DME-5607761); (R-DME-5607764); (R-DME-5676590); (R-DME-6811436); (R-DME-69601); (R-DME-8951664); (R-DME-983168)", "pathway_count": 12, "publication_count": 19, "publication_id_list": "10498683;10559989;10731132;10737922;10993674;11056531;12537568;12537569;12537572;12537573;12537574;16105886;16107559;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as nuclear migration during cell division, mitotic spindle formation and the removal of mitotic checkpoint proteins from kinetochores at the metaphase to anaphase transition. Required for several aspects of neurogenesis including neuroblast proliferation, neuronal cell differentiation, dendritic growth, branching and maturation and axonal transport. Required for synchronized cell divisions in the germline, fusome integrity and oocyte differentiation. Acts together with BicD, Egl, dynein and microtubules to determine oocyte identity during oogenesis. Also required for nurse cell to oocyte transport during oocyte growth and for the positioning of the nucleus in the oocyte., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4UZJ3;O96698;Q5BI20;Q8SXJ6", "ec_number_list": [], "go_molecular_function": "GO:0051010 microtubule plus-end binding;GO:0070840 dynein complex binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005635 nuclear envelope;GO:0005813 centrosome;GO:0005938 cell cortex;GO:0030424 axon", "go_biological_process": "GO:0051383 kinetochore organization;GO:0008090 retrograde axonal transport;GO:0006886 intracellular protein transport;GO:0007283 spermatogenesis;GO:0008088 axo-dendritic transport", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q7KNS3-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9GYV5-1", "uniprot_id": [ { "id": "NEMO_DROME", "url": "https://www.uniprot.org/uniprot/Q9GYV5", "type": "external" } ], "mass": 43879.0, "length": 387, "protein_name": "NF-kappa-B essential modulator", "gene_name": "key", "organism": "Fruit fly", "refseq_name": "kenny, isoform A", "refseq_ac": [ { "id": "NP_523856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523856", "type": "external" } ], "gene_names_uniprotkb": "key; CG16910; DmIKK-gamma; DmIKKgamma; Dmel\\CG16910; Dmel_CG16910; Dmikkgamma; IKK-gamma; IKKGAMMA; IKKG; IKK[[gamma]]; IKKgamma; IKKg; IKK; Ikkgammabeta; KEY; Kenny; Key; dIKK-gamma; dIKKgamma; dIKK; dmIKKgamma", "gene_names_refseq": "CG16910; DmIKK-gamma; DmIKKgamma; Dmel\\CG16910; Dmikkgamma; IKK-gamma; IKKG; IKK[[gamma]]; IKKgamma; IKKg; IKK; Ikkgammabeta; KEY; Kenny; Key; dIKK-gamma; dIKKgamma; dIKK; dmIKKgamma; key", "protein_names_uniprotkb": "NF-kappa-B essential modulator; DmIKKgamma; Inhibitor of nuclear factor kappa B kinase subunit gamma; NEMO homolog", "protein_names_refseq": "CG16910-PA; kenney; kenny, isoform A; kenny; key-PA", "tax_id": 7227, "disease": "amyotrophic lateral sclerosis type 12 (Disease Ontology:DOID:0060203); ectodermal dysplasia and immunodeficiency 1 (Disease Ontology:DOID:0081078); neuronal intranuclear inclusion disease (Disease Ontology:DOID:0081294); immunodeficiency 33 (Disease Ontology:DOID:0112003); open-angle glaucoma (Disease Ontology:DOID:1067); primary open angle glaucoma (Disease Ontology:DOID:1070); Bloch-Sulzberger syndrome (Disease Ontology:DOID:12305); Huntington's disease (Disease Ontology:DOID:12858); Behcet's disease (Disease Ontology:DOID:13241); low tension glaucoma (Disease Ontology:DOID:13544); bladder neck obstruction (Disease Ontology:DOID:13948); Parkinson's disease (Disease Ontology:DOID:14330); glaucoma (Disease Ontology:DOID:1686); transient cerebral ischemia (Disease Ontology:DOID:224); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); liver cancer (Disease Ontology:DOID:3571); Paget's disease of bone (Disease Ontology:DOID:5408); proteinuria (Disease Ontology:DOID:576); hepatocellular carcinoma (Disease Ontology:DOID:684); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); progressive myoclonus epilepsy (Disease Ontology:DOID:891); learning disability (Disease Ontology:DOID:8927); acute myocardial infarction (Disease Ontology:DOID:9408); steatotic liver disease (Disease Ontology:DOID:9452); irritable bowel syndrome (Disease Ontology:DOID:9778)", "pathway": " (dme:Dmel_CG16910); (R-DME-1169091); (R-DME-1810476); (R-DME-202424); (R-DME-209447); (R-DME-214399); (R-DME-2565942); (R-DME-2871837); (R-DME-445989); (R-DME-5205685); (R-DME-5357905); (R-DME-5607764); (R-DME-5689880); (R-DME-8854214); (R-DME-9020702); (R-DME-933542); (R-DME-937039); (R-DME-975144); (R-DME-9758274); (R-DME-9833482); (R-DME-9860927); (R-DME-9909505)", "pathway_count": 22, "publication_count": 19, "publication_id_list": "10731132;11018014;12537568;12537569;12537572;12537573;12537574;12732719;14519762;16081424;16110336;16311020;16894030;17158449;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Essential signaling component in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation, which is required for NF-kappa-B (Rel) activation. Required for antibacterial immune response., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 25, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W105", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:2000647 negative regulation of stem cell proliferation;GO:0006955 immune response;GO:0045087 innate immune response;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050829 defense response to Gram-negative bacterium", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9GYV5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9U1I1-1", "uniprot_id": [ { "id": "ESN_DROME", "url": "https://www.uniprot.org/uniprot/Q9U1I1", "type": "external" } ], "mass": 86608.0, "length": 785, "protein_name": "Protein espinas", "gene_name": "esn", "organism": "Fruit fly", "refseq_name": "espinas, isoform B", "refseq_ac": [ { "id": "NP_524990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524990", "type": "external" } ], "gene_names_uniprotkb": "esn; CG12833; CG12835; CG43722; Dm_2R:11728; Dmel\\CG43722; Dmel_CG43722; Esn", "gene_names_refseq": "CG12833; CG12835; CG43722; Dm_2R:11728; Dmel\\CG43722; Esn; esn", "protein_names_uniprotkb": "Protein espinas", "protein_names_refseq": "CG43722-PB; esn-PB; espinas, isoform B; espinas", "tax_id": 7227, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal recessive Robinow syndrome (Disease Ontology:DOID:0060764); progressive myoclonus epilepsy 1B (Disease Ontology:DOID:0111448); Leber plus disease (Disease Ontology:DOID:0111754); velocardiofacial syndrome (Disease Ontology:DOID:12583); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (dme:Dmel_CG43722)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10485852;10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A8E6H1;Q8SX20;Q9V4H9", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "GO:0070593 dendrite self-avoidance;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9U1I1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V3C1-1", "uniprot_id": [ { "id": "VHL_DROME", "url": "https://www.uniprot.org/uniprot/Q9V3C1", "type": "external" } ], "mass": 21240.0, "length": 178, "protein_name": "Protein Vhl", "gene_name": "Vhl", "organism": "Fruit fly", "refseq_name": "von Hippel-Lindau, isoform B", "refseq_ac": [ { "id": "NP_001260885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260885", "type": "external" } ], "gene_names_uniprotkb": "Vhl; BcDNA:RH61560; CG13221; DVhl; Dmel\\CG13221; Dmel_CG13221; Dvhl; VHL; d-VHL; d-vhl; dVHL; dmVHL; vhl", "gene_names_refseq": "BcDNA:RH61560; CG13221; DVhl; Dmel\\CG13221; Dvhl; VHL; Vhl; d-VHL; d-vhl; dVHL; dmVHL; vhl", "protein_names_uniprotkb": "Protein Vhl", "protein_names_refseq": "CG13221-PB; Vhl-PB; von Hippel-Lindau, isoform B; von hippel lindau protein; von hippel lindau", "tax_id": 7227, "disease": "pheochromocytoma (Disease Ontology:DOID:0050771); familial erythrocytosis 2 (Disease Ontology:DOID:0060474); Parkinsonism (Disease Ontology:DOID:0080855); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); von Hippel-Lindau disease (Disease Ontology:DOID:14175); pancreatic cancer (Disease Ontology:DOID:1793); nephroblastoma (Disease Ontology:DOID:2154); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); hepatocellular carcinoma (Disease Ontology:DOID:684); polycythemia (Disease Ontology:DOID:8432); sudden infant death syndrome (Disease Ontology:DOID:9007); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG13221); (R-DME-1234176); (R-DME-8951664); (R-DME-983168)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "10731132;10851083;11006129;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;22451918;25589440;26109356;26109357", "class_list": "", "function": "Involved in development of tracheal vasculature. Probably involved in halting cell migration at the end of vascular tube outgrowth. Possesses E3 ubiquitin ligase activity when in complex with Elongin BC complex, Cul2 and Rox1a/Rbx1, and can target sima/Hif1a for ubiquitination. May play a critical role in promoting microtubule stabilization when tubulins are correctly folded by the prefoldin complex. If tubulin is incorrectly folded, may promote its degradation., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0030891 VCB complex;GO:0005634 nucleus", "go_biological_process": "GO:0030154 cell differentiation;GO:0090307 mitotic spindle assembly;GO:0016567 protein ubiquitination;GO:0007026 negative regulation of microtubule depolymerization;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9V3C1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V637-1", "uniprot_id": [ { "id": "PSMF1_DROME", "url": "https://www.uniprot.org/uniprot/Q9V637", "type": "external" } ], "mass": 30088.0, "length": 270, "protein_name": "Proteasome inhibitor PI31 subunit", "gene_name": "PI31", "organism": "Fruit fly", "refseq_name": "proteasome inhibitor 31 kDa, isoform D", "refseq_ac": [ { "id": "NP_001260905", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260905", "type": "external" } ], "gene_names_uniprotkb": "PI31; 8979; CG8979; DmPI31; Dmel\\CG8979; Dmel_CG8979; cg8979; dmPI31", "gene_names_refseq": "8979; CG8979; DmPI31; Dmel\\CG8979; PI31; cg8979; dmPI31", "protein_names_uniprotkb": "Proteasome inhibitor PI31 subunit", "protein_names_refseq": "CG8979-PD; PI31-PD; proteasome inhibitor 31 kDa, isoform D", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8979)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17372656;17569856;17569867;18327897;21529711;23622245;25589440;26109356;26109357", "class_list": "", "function": "Plays an important role in the control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Enhances 26S proteasome function by promoting its assembly through the interaction with the assembly chaperones PSMD9 and PMSD5. Functions together with ntc to control non-apoptotic caspase activation during sperm individualization. In testis, is required for proper protein degradation and germline cell cycle progression., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4UZD9;Q0E9B8", "ec_number_list": [], "go_molecular_function": "GO:0004866 endopeptidase inhibitor activity;GO:0070628 proteasome binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000502 proteasome complex;GO:0070864 sperm individualization complex", "go_biological_process": "GO:0008584 male gonad development;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0007140 male meiotic nuclear division;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9V637-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8MSF5-1", "uniprot_id": [ { "id": "RNK_DROME", "url": "https://www.uniprot.org/uniprot/Q8MSF5", "type": "external" } ], "mass": 10763.0, "length": 95, "protein_name": "Ribonuclease kappa", "gene_name": "RNASEK", "organism": "Fruit fly", "refseq_name": "ribonuclease kappa, isoform A", "refseq_ac": [ { "id": "NP_001036433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036433", "type": "external" } ], "gene_names_uniprotkb": "RNASEK; BcDNA:GM16138; CG40127; Dmel\\CG40127; Dmel_CG40127; GM16138; NC110; anon-EST:Posey156; dRNASEK; l(2)NC110", "gene_names_refseq": "BcDNA:GM16138; CG40127; Dmel\\CG40127; GM16138; NC110; RNASEK; anon-EST:Posey156; dRNASEK; l(2)NC110", "protein_names_uniprotkb": "Ribonuclease kappa; 3.1.-.-; RNase K; RNase kappa", "protein_names_refseq": "CG40127-PA; RNASEK-PA; lethal (2) NC110; ribonuclease kappa, isoform A; ribonuclease kappa", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG40127)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26056282;26109356;26109357", "class_list": "", "function": "(Microbial infection) Required for the initial stages of clathrin-mediated endocytic uptake of a diverse set of flaviviruses, including dengue and West Nile (PubMed:26056282). Not required for clathrin-mediated endocytosis and macropinocytosis (PubMed:26056282)., [UniProtKB, PubMed]; Endoribonuclease., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0098586 cellular response to virus", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8MSF5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V730-1", "uniprot_id": [ { "id": "EXT1_DROME", "url": "https://www.uniprot.org/uniprot/Q9V730", "type": "external" } ], "mass": 87309.0, "length": 760, "protein_name": "Exostosin-1", "gene_name": "ttv", "organism": "Fruit fly", "refseq_name": "tout-velu, isoform B", "refseq_ac": [ { "id": "NP_001260971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260971", "type": "external" } ], "gene_names_uniprotkb": "ttv; CG10117; DEXT1; Dmel\\CG10117; Dmel_CG10117; EXT1; Ext1; P1.15; Ttv; dExt1; l(2)00681; l(2)05282; l(2)SH0631; l(2)SH2 0631; l(2)k00115; l(2)k03617", "gene_names_refseq": "CG10117; DEXT1; Dmel\\CG10117; EXT1; Ext1; P1.15; Ttv; dExt1; l(2)00681; l(2)05282; l(2)SH0631; l(2)SH2 0631; l(2)k00115; l(2)k03617; ttv", "protein_names_uniprotkb": "Exostosin-1; 2.4.1.224; 2.4.1.225; Protein tout-velu; TTV", "protein_names_refseq": "CG10117-PB; Tout-velu; lethal (2) SH0631; tout velour; tout velu; tout-velo; tout-velu, isoform B; toutvelu; ttv-PB", "tax_id": 7227, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); hereditary multiple exostoses (Disease Ontology:DOID:206); germ cell cancer (Disease Ontology:DOID:2994); chondrosarcoma (Disease Ontology:DOID:3371)", "pathway": " (dme:Dmel_CG10117); (R-DME-2022928)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "10549295;10644674;10731132;10806213;12537568;12537572;12537573;12537574;12586063;14645127;14729575;14998928;15056609;16110336;16303756;17569856;17569867;23720043;25589440;26109356;26109357;9665133", "class_list": "glycogene;glycosyltransferase", "function": "Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. Botv is the trigger of heparan sulfate chain initiation and polymerization takes place by a complex of ttv and sotv. Plays a central role in the diffusion of morphogens hedgehog (hh), wingless (wg) and decapentaplegic (dpp) via its role in heparan sulfate proteoglycans (HSPGs) biosynthesis which are required for movement of hh, dpp and wg morphogens., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O76796;Q5BI21", "ec_number_list": [ { "id": "2.4.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.17", "type": "external" }, { "id": "2.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.-.-", "type": "external" }, { "id": "2.4.1.224", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.224", "type": "external" }, { "id": "2.4.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.225", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008375 acetylglucosaminyltransferase activity;GO:0015020 glucuronosyltransferase activity;GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity;GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016055 Wnt signaling pathway;GO:0006024 glycosaminoglycan biosynthetic process;GO:0030210 heparin proteoglycan biosynthetic process;GO:0015012 heparan sulfate proteoglycan biosynthetic process;GO:0008354 germ cell migration", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9V730-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000011000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24459-1", "uniprot_id": [ { "id": "PCL_DROME", "url": "https://www.uniprot.org/uniprot/Q24459", "type": "external" } ], "mass": 114638.0, "length": 1043, "protein_name": "Polycomb protein Pcl", "gene_name": "Pcl", "organism": "Fruit fly", "refseq_name": "polycomblike, isoform B", "refseq_ac": [ { "id": "NP_001261067", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261067", "type": "external" } ], "gene_names_uniprotkb": "Pcl; CG5109; Dmel\\CG5109; Dmel_CG5109; PCL; dPcl; l(2)s1859; pcl", "gene_names_refseq": "CG5109; Dmel\\CG5109; PCL; Pcl; dPcl; l(2)s1859; pcl", "protein_names_uniprotkb": "Polycomb protein Pcl; Polycomblike protein", "protein_names_refseq": "CG5109-PB; Pcl-PB; Polycomb-like; polycomblike, isoform B; polycomblike", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5109)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10731132;11571280;12537568;12537569;12537572;12537573;12537574;12697833;16110336;17569856;17569867;18327897;23104054;23142980;25589440;26109356;26109357;7956837", "class_list": "", "function": "Polycomb group (PcG) protein. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. Component of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3, leading to transcriptional repression of the affected target gene. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required. Required for the correct spatial expression of the homeotic genes of the Antennapedia and Bithorax complexes., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8T8P9;Q9V8C2", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008017 microtubule binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048188 Set1C/COMPASS complex;GO:0005700 polytene chromosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q24459-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04448-1", "uniprot_id": [ { "id": "MTDC_DROME", "url": "https://www.uniprot.org/uniprot/Q04448", "type": "external" } ], "mass": 33551.0, "length": 309, "protein_name": "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial", "gene_name": "Nmdmc", "organism": "Fruit fly", "refseq_name": "NAD-dependent methylenetetrahydrofolate dehydrogenase, isoform C", "refseq_ac": [ { "id": "NP_001262398", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262398", "type": "external" } ], "gene_names_uniprotkb": "Nmdmc; 151767_at; CG18466; DNMDMC; Dmdmc; Dmel\\CG18466; Dmel_CG18466; Dnmdmc; Mthfd2; dNMDMC; nmdmc", "gene_names_refseq": "151767_at; CG18466; DNMDMC; Dmdmc; Dmel\\CG18466; Dnmdmc; Mthfd2; Nmdmc; dNMDMC; nmdmc", "protein_names_uniprotkb": "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; DNMDMC", "protein_names_refseq": "CG18466-PC; NAD dependent methylenetetrahydrofolate dehydrogenase; NAD-dependent methylenetetrahydrofolate dehydrogenase, isoform C; Nmdmc-PC", "tax_id": 7227, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dme:Dmel_CG18466); (R-DME-196757)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10619029;10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8485162", "class_list": "", "function": "May play a role in spermatogenesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7KSU1;Q9U6H6;Q9V3H4", "ec_number_list": [ { "id": "6.3.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.3", "type": "external" }, { "id": "1.5.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.5", "type": "external" }, { "id": "3.5.4.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.9", "type": "external" }, { "id": "1.5.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.15", "type": "external" } ], "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0000287 magnesium ion binding;GO:0004477 methenyltetrahydrofolate cyclohydrolase activity;GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity;GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0035999 tetrahydrofolate interconversion;GO:0046653 tetrahydrofolate metabolic process;GO:0006730 one-carbon metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q04448-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VHB3-1", "uniprot_id": [ { "id": "USB1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VHB3", "type": "external" } ], "mass": 28991.0, "length": 258, "protein_name": "U6 snRNA phosphodiesterase 1", "gene_name": "Dmel\\CG16790", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform A", "refseq_ac": [ { "id": "NP_649911", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649911", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG16790; CG16790; Dmel_CG16790", "gene_names_refseq": "CG16790; Dmel\\CG16790", "protein_names_uniprotkb": "U6 snRNA phosphodiesterase 1; 3'-5' RNA exonuclease USB1; 4.6.1.-", "protein_names_refseq": "CG16790-PA; uncharacterized protein, isoform A", "tax_id": 7227, "disease": "ablepharon macrostomia syndrome (Disease Ontology:DOID:0060550); poikiloderma with neutropenia (Disease Ontology:DOID:0060551)", "pathway": " (dme:Dmel_CG16790)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "3'-5' RNA exonuclease that trims the 3' end of oligo(U) tracts of the pre-U6 small nuclear RNA (snRNA) molecule, leading to the formation of a mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. Participates in the U6 snRNA 3' end processing that prevents U6 snRNA degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4QQ73;Q4QQ86", "ec_number_list": [ { "id": "4.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0016829 lyase activity;GO:0000175 3'-5'-RNA exonuclease activity;GO:1990838 poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0034477 U6 snRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VHB3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04164-1", "uniprot_id": [ { "id": "SAS_DROME", "url": "https://www.uniprot.org/uniprot/Q04164", "type": "external" } ], "mass": 185254.0, "length": 1693, "protein_name": "Putative epidermal cell surface receptor", "gene_name": "sas", "organism": "Fruit fly", "refseq_name": "stranded at second, isoform C", "refseq_ac": [ { "id": "NP_001262336", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262336", "type": "external" } ], "gene_names_uniprotkb": "sas; CG2507; Dmel\\CG2507; Dmel_CG2507; SAS; Sas; l(3)84Cd; rfd", "gene_names_refseq": "CG2507; Dmel\\CG2507; SAS; Sas; l(3)84Cd; rfd; sas", "protein_names_uniprotkb": "Putative epidermal cell surface receptor; Stranded at second protein", "protein_names_refseq": "CG2507-PC; responsible for dominant phenotype; sas-PC; stranded at second, isoform C; stranded at second; stranded-at-second", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2507)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;1339334;16110336;17569856;17569867;24718992;25589440;26109356;26109357", "class_list": "", "function": "Vital for larval development (PubMed:1339334). During salivary tube elongation, possibly modulates cellular adhesion between the apical surface and apical extracellular matrix, and acts as an apical membrane determinant that functions in apical membrane expansion independently of crb and Cad99C (PubMed:24718992)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 16, "predicted_n_glycosites": 14, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "Q960M6;Q9VI73", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005178 integrin binding;GO:0038023 signaling receptor activity;GO:0140177 membrane-membrane adaptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0070062 extracellular exosome;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0099156 cell-cell signaling via exosome;GO:0007155 cell adhesion;GO:0045597 positive regulation of cell differentiation;GO:0007411 axon guidance;GO:0002168 instar larval development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q04164-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V853-1", "uniprot_id": [ { "id": "SMUF1_DROME", "url": "https://www.uniprot.org/uniprot/Q9V853", "type": "external" } ], "mass": 115676.0, "length": 1061, "protein_name": "E3 ubiquitin-protein ligase Smurf1", "gene_name": "Smurf", "organism": "Fruit fly", "refseq_name": "SMAD specific E3 ubiquitin protein ligase, isoform B", "refseq_ac": [ { "id": "NP_001261061", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261061", "type": "external" } ], "gene_names_uniprotkb": "Smurf; CG4943; D-smurf; DSmurf; Dmel\\CG4943; Dmel_CG4943; Dsmurf; LACK; Lack; SMURF; Smurf ubiquitin ligase; Smurf1; d-smurf; dSmurf1; dSmurf; lack; smurf", "gene_names_refseq": "CG4943; D-smurf; DSmurf; Dmel\\CG4943; Dsmurf; LACK; Lack; SMURF; Smurf ubiquitin ligase; Smurf; d-smurf; dSmurf1; dSmurf; lack; smurf", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Smurf1; 2.3.2.26; DSmurf; HECT-type E3 ubiquitin transferase Smurf1; Lethal with a checkpoint kinase protein; SMAD ubiquitination regulatory factor 1 homolog", "protein_names_refseq": "CG4943-PB; SMAD specific E3 ubiquitin protein ligase, isoform B; Smurf-PB; Smurf1; lethal with a checkpoint kinase; smad ubiquitination regulatory factor; smurf E3 ligase; smurf", "tax_id": 7227, "disease": "diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745)", "pathway": " (dme:Dmel_CG4943); (R-DME-201451); (R-DME-2173788); (R-DME-2173791); (R-DME-2173795); (R-DME-4608870); (R-DME-4641257); (R-DME-5632684); (R-DME-5689880); (R-DME-8941858); (R-DME-983168)", "pathway_count": 11, "publication_count": 15, "publication_id_list": "10731132;11703946;12537568;12537572;12537573;12537574;12754252;16110336;17569856;17569867;18327897;24302888;25589440;26109356;26109357", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:11703946, PubMed:12754252, PubMed:24302888). Down-regulates Dpp signaling after gastrulation by promoting MAD ubiquitination and subsequent degradation (PubMed:12754252). Acts as a positive regulator of smoothened signaling pathway by mediating ubiquitination of patched (ptc), leading to ptc endocytosis and lysosomal degradation (PubMed:24302888)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 0, "predicted_o_glycosites": 8, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q9U3W2", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "5.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.5", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0048619 embryonic hindgut morphogenesis;GO:0040008 regulation of growth;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0030514 negative regulation of BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9V853-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8T0S6-1", "uniprot_id": [ { "id": "HIPPO_DROME", "url": "https://www.uniprot.org/uniprot/Q8T0S6", "type": "external" } ], "mass": 75110.0, "length": 669, "protein_name": "Serine/threonine-protein kinase hippo", "gene_name": "hpo", "organism": "Fruit fly", "refseq_name": "hippo, isoform B", "refseq_ac": [ { "id": "NP_001261092", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261092", "type": "external" } ], "gene_names_uniprotkb": "hpo; 2; CG11228; Dmel\\CG11228; Dmel_CG11228; HPO; Hippo; Hpo; MST2; MST; Wts; dMST; hipo", "gene_names_refseq": "CG11228; Dmel\\CG11228; HPO; Hippo; Hpo/Wts; Hpo; MST2; MST; Mst1/2; dMST; hipo; hpo", "protein_names_uniprotkb": "Serine/threonine-protein kinase hippo; 2.7.11.1; Drosophila homolog of MST1 and MST2; STE20-like kinase MST; dMST", "protein_names_refseq": "CG11228-PB; HIPPO; MST; hippo kinase; hippo, isoform B; hpo-PB", "tax_id": 7227, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); cancer (Disease Ontology:DOID:162); carcinoma (Disease Ontology:DOID:305); primary immunodeficiency disease (Disease Ontology:DOID:612); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG11228); (R-DME-2028269); (R-DME-390089); (R-DME-390098); (R-DME-390150); (R-DME-451806)", "pathway_count": 6, "publication_count": 37, "publication_id_list": "10731132;11900973;12091301;12202036;12223493;12537568;12537569;12537572;12537573;12537574;12941273;12941274;14502294;14502295;14561774;15766530;16096061;16110336;17174922;17347649;17569856;17569867;17889654;18256197;18327897;19289086;19330023;19710173;19733165;20159598;22075147;23940457;25589440;26109356;26109357;26954546;27462435", "class_list": "", "function": "Plays a key role in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Phosphorylates Sav, Wts and Th/DIAP1. Regulates the level of Th/DIAP1 apoptosis inhibitor., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9V8W4", "ec_number_list": [ { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "5.6.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.8", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0016324 apical plasma membrane;GO:0106037 apicomedial cortex", "go_biological_process": "GO:2001233 regulation of apoptotic signaling pathway;GO:1901526 positive regulation of mitophagy;GO:0006468 protein phosphorylation;GO:0008285 negative regulation of cell population proliferation;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "Q8T0S6-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VH20-1", "uniprot_id": [ { "id": "TAF1B_DROME", "url": "https://www.uniprot.org/uniprot/Q9VH20", "type": "external" } ], "mass": 101775.0, "length": 872, "protein_name": "TATA box-binding protein-associated factor RNA polymerase I subunit B", "gene_name": "TAF1B", "organism": "Fruit fly", "refseq_name": "TATA box-binding protein-associated factor RNA polymerase I subunit B, isoform C", "refseq_ac": [ { "id": "NP_001262451", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262451", "type": "external" } ], "gene_names_uniprotkb": "TAF1B; CG6241; Dmel\\CG6241; Dmel_CG6241; TAF1b; Taf1B", "gene_names_refseq": "CG6241; Dmel\\CG6241; TAF1B; TAF1b; Taf1B", "protein_names_uniprotkb": "TATA box-binding protein-associated factor RNA polymerase I subunit B; TATA box-binding protein-associated factor 1B; TBP-associated factor 1B", "protein_names_refseq": "CG6241-PC; TAF1B-PC; TATA box-binding protein-associated factor RNA polymerase I subunit B, isoform C", "tax_id": 7227, "disease": "mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); Lynch syndrome (Disease Ontology:DOID:3883)", "pathway": " (dme:Dmel_CG6241); (R-DME-73772)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q494H4;Q8MRI0", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding", "go_cellular_component": "GO:0005668 RNA polymerase transcription factor SL1 complex;GO:0005730 nucleolus;GO:0070860 RNA polymerase I core factor complex", "go_biological_process": "GO:0042790 nucleolar large rRNA transcription by RNA polymerase I;GO:0001188 RNA polymerase I preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VH20-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VET0-1", "uniprot_id": [ { "id": "NPF_DROME", "url": "https://www.uniprot.org/uniprot/Q9VET0", "type": "external" } ], "mass": 11465.0, "length": 102, "protein_name": "Neuropeptide F", "gene_name": "NPF", "organism": "Fruit fly", "refseq_name": "neuropeptide F, isoform B", "refseq_ac": [ { "id": "NP_001262642", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262642", "type": "external" } ], "gene_names_uniprotkb": "NPF; CG10342; Dm-NPF; DmNPF; Dmel\\CG10342; Dmel_CG10342; Drm-NPF; NP-PP; NPF-A1; NPF-A2; NPF89D3; NPY; Npf; dNPF; dnpf; npf; sNPF", "gene_names_refseq": "CG10342; Dm-NPF; DmNPF; Dmel\\CG10342; Drm-NPF; NP-PP; NPF-A1; NPF-A2; NPF/NPY; NPF89D3; NPF; Npf; dNPF; dnpf; npf; sNPF", "protein_names_uniprotkb": "Neuropeptide F; NPF; dNPF", "protein_names_refseq": "CG10342-PB; NPF-PB; NPY-like neuropeptide F; long neuropeptide F; neuropeptide F 1; neuropeptide F, isoform B; neuropeptide-F", "tax_id": 7227, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (dme:Dmel_CG10342)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10499420;10731132;11257610;12537568;12537572;12537573;12537574;12848939;15677721;16110336;17569856;17569867;19837040;20164335;22422983;25589440;26109356;26109357", "class_list": "", "function": "Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive effect on larval aversion to diverse stressful stimuli (chemical stress and noxious heat) through attenuation of TRP channel-induced neuronal excitation. NPF neural signaling system plays a physiological role in acute modulation of alcohol sensitivity in adults, rather than a general response to intoxication by sedative agents. Activation and inhibition of the NPF system reduces and enhances ethanol preference, respectively. Sexual experience, the NPF system activity and ethanol consumption are all linked; sexual deprivation is a major contributor to enhanced ethanol preference., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9Y1K3", "ec_number_list": [], "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0005184 neuropeptide hormone activity;GO:0071859 neuropeptide F receptor binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0008049 male courtship behavior;GO:0042048 olfactory behavior;GO:0032095 regulation of response to food;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9VET0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V813-1", "uniprot_id": [ { "id": "MTAP_DROME", "url": "https://www.uniprot.org/uniprot/Q9V813", "type": "external" } ], "mass": 32018.0, "length": 289, "protein_name": "S-methyl-5'-thioadenosine phosphorylase", "gene_name": "Mtap", "organism": "Fruit fly", "refseq_name": "methylthioadenosine phosphorylase, isoform C", "refseq_ac": [ { "id": "NP_001286525", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286525", "type": "external" } ], "gene_names_uniprotkb": "Mtap; CG4802; Dmel\\CG4802; Dmel_CG4802; MTAP", "gene_names_refseq": "CG4802; Dmel\\CG4802; MTAP; Mtap", "protein_names_uniprotkb": "S-methyl-5'-thioadenosine phosphorylase; 2.4.2.28; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAPase; MTAP", "protein_names_refseq": "CG4802-PC; Mtap-PC; methylthioadenosine phosphorylase ortholog; methylthioadenosine phosphorylase, isoform C", "tax_id": 7227, "disease": "biliary tract benign neoplasm (Disease Ontology:DOID:0050625); diaphyseal medullary stenosis with malignant fibrous histiocytoma (Disease Ontology:DOID:0080664); pancreatic cancer (Disease Ontology:DOID:1793); common bile duct neoplasm (Disease Ontology:DOID:4608)", "pathway": " (dme:Dmel_CG4802); (R-DME-1237112)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17534888;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Catalyzes the phosphorolytic cleavage of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates., [UniProtKB, HAMAP]; Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.2.28", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.28", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0017061 S-methyl-5-thioadenosine phosphorylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006166 purine ribonucleoside salvage;GO:0019509 L-methionine salvage from methylthioadenosine", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9V813-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24151-1", "uniprot_id": [ { "id": "STAT_DROME", "url": "https://www.uniprot.org/uniprot/Q24151", "type": "external" } ], "mass": 86415.0, "length": 761, "protein_name": "Signal transducer and transcription activator", "gene_name": "Stat92E", "organism": "Fruit fly", "refseq_name": "Signal-transducer and activator of transcription protein at 92E, isoform G", "refseq_ac": [ { "id": "NP_001014643", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014643", "type": "external" } ], "gene_names_uniprotkb": "Stat92E; CG4257; D-STAT; D-Stat; D-stat; DRODSRC; DSRC; DSTAT; DmSTAT; Dmel\\CG4257; Dmel_CG4257; Dstat 92E; Dstat92E; Dstat; Dst; MARE; SD-stat; STAT 92E; STAT92E; STAT92e; STAT92; STAT; Sta92E; Stat1alpha-like; Stat92e; Stat92; Stat9E; Stat; d-STAT; dSTAT92E; dSTAT; dstat; l(3)06346; l(3)j6C8; marelle; mrL; mrl stat92E; mrl; pSTAT92E; pSTAT; stat92E; stat92e; stat92; stat[92E]; stat", "gene_names_refseq": "CG4257; D-STAT; D-Stat; D-stat/stat92E; D-stat; DRODSRC; DSRC; DSTAT; DmSTAT; Dmel\\CG4257; Dstat 92E; Dstat92E; Dstat; Dst; SD-stat; STAT 92E; STAT92E; STAT92e; STAT92; STAT; Sta92E; Stat1alpha-like; Stat92E; Stat92e; Stat92; Stat9E; Stat; d-STAT; dSTAT92E/marelle; dSTAT92E; dSTAT; dstat; l(3)06346; l(3)j6C8; mrL; mrl stat92E; mrl; pSTAT92E; pSTAT; stat92E; stat92e; stat92; stat[92E]; stat", "protein_names_uniprotkb": "Signal transducer and transcription activator; Protein marelle; d-STAT", "protein_names_refseq": "CG4257-PG; Signal-transducer and activator of transcription protein at 92E, isoform G; Signal-transducer and activator of transcription protein; Stat92E-PG; marelle; signal transducer and activator of transcription; signal transducers and activator of transcription; stat92E", "tax_id": 7227, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); renal fibrosis (Disease Ontology:DOID:0050855); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); pre-malignant neoplasm (Disease Ontology:DOID:0060071); ductal carcinoma in situ (Disease Ontology:DOID:0060074); Zika fever (Disease Ontology:DOID:0060478); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); colorectal carcinoma (Disease Ontology:DOID:0080199); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); growth hormone insensitivity syndrome with immune dysregulation 1 (Disease Ontology:DOID:0080836); growth hormone insensitivity syndrome with immune dysregulation 2 (Disease Ontology:DOID:0080837); castration-resistant prostate carcinoma (Disease Ontology:DOID:0080909); immunodeficiency 44 (Disease Ontology:DOID:0111975); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); lipoid nephrosis (Disease Ontology:DOID:10966); heart disease (Disease Ontology:DOID:114); neutropenia (Disease Ontology:DOID:1227); urinary schistosomiasis (Disease Ontology:DOID:1394); breast cancer (Disease Ontology:DOID:1612); duodenal ulcer (Disease Ontology:DOID:1724); hepatitis C (Disease Ontology:DOID:1883); hyperuricemia (Disease Ontology:DOID:1920); atherosclerosis (Disease Ontology:DOID:1936); rectum adenocarcinoma (Disease Ontology:DOID:1996); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); colon adenocarcinoma (Disease Ontology:DOID:234); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); glioblastoma (Disease Ontology:DOID:3068); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); autosomal dominant hyper-IgE syndrome 1 with recurrent infections (Disease Ontology:DOID:3261); invasive lobular carcinoma (Disease Ontology:DOID:3457); gastric adenocarcinoma (Disease Ontology:DOID:3717); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); myocarditis (Disease Ontology:DOID:820); chronic myeloid leukemia (Disease Ontology:DOID:8552); psoriasis (Disease Ontology:DOID:8893); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); colorectal cancer (Disease Ontology:DOID:9256); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970); peripartum cardiomyopathy (Disease Ontology:DOID:9997)", "pathway": " (dme:Dmel_CG4257); (R-DME-1059683); (R-DME-1251985); (R-DME-186763); (R-DME-201556); (R-DME-209228); (R-DME-209394); (R-DME-209405); (R-DME-210671); (R-DME-210688); (R-DME-210693); (R-DME-3249367); (R-DME-6783783); (R-DME-6785807); (R-DME-877300); (R-DME-877312); (R-DME-8854691); (R-DME-8983432); (R-DME-8984722); (R-DME-8985947); (R-DME-9008059); (R-DME-9020591); (R-DME-9020933); (R-DME-9020956); (R-DME-909733); (R-DME-9701898); (R-DME-9833482); (R-DME-9860927)", "pathway_count": 28, "publication_count": 36, "publication_id_list": "10409696;10731132;10805787;10823841;11269501;11390354;11504941;11825879;12537568;12537569;12537572;12537573;12537574;12732719;15640802;15659391;16055650;16094372;16110336;16129580;16401426;16477645;17569856;17569867;17803358;18327897;25589440;26109356;26109357;34644293;8463208;8608595;8608596;9388184;9671298;9770450", "class_list": "", "function": "Might play a role in signal transduction and activation of transcription. Plays an important role in the segmental pattern formation in the early embryo by activating specific stripes of pair rule gene expression in early development as part of the Janus kinase-STAT pathway (PubMed:8608595). Might play a role in male germline stem cell maintenance (PubMed:34644293)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 48, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0KI43;Q24181;Q59DV7;Q5BIB0;Q8IN54;Q8SX55;Q9VDL8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0042393 histone binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0098592 cytoplasmic side of apical plasma membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007442 hindgut morphogenesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006952 defense response;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "Q24151-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9U6L5-1", "uniprot_id": [ { "id": "PEB1_DROME", "url": "https://www.uniprot.org/uniprot/Q9U6L5", "type": "external" } ], "mass": 37819.0, "length": 377, "protein_name": "Ejaculatory bulb-specific protein 1", "gene_name": "Ebp", "organism": "Fruit fly", "refseq_name": "ejaculatory bulb protein, isoform B", "refseq_ac": [ { "id": "NP_001261178", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261178", "type": "external" } ], "gene_names_uniprotkb": "Ebp; BcDNA:GH06048; CG2668; Dmel\\CG2668; Dmel_CG2668; EBP; FBgn0004181; P38; PEB-me; PEBme; PEB; Peb; anon-WO0140519.140; peb", "gene_names_refseq": "BcDNA:GH06048; CG2668; Dmel\\CG2668; EBP; Ebp; FBgn0004181; P38; PEB-me; PEBme; PEB; Peb; anon-WO0140519.140; peb", "protein_names_uniprotkb": "Ejaculatory bulb-specific protein 1; Ejaculatory bulb-specific protein I; PEB-me", "protein_names_refseq": "CG2668-PB; Ebp-PB; ejaculatory bulb protein, isoform B; ejaculatory bulb protein; protein ejaculatory bulb", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2668)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;10731138;11267893;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Major protein component of the posterior mating plug. Accessory gland proteins constitute, or are required for formation of the anterior mating plug. Posterior mating plug forms before sperm transfer and the anterior mating plug is formed after the start of mating., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W0W1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007320 insemination;GO:0042628 mating plug formation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9U6L5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q86NP2-1", "uniprot_id": [ { "id": "NELFA_DROME", "url": "https://www.uniprot.org/uniprot/Q86NP2", "type": "external" } ], "mass": 134949.0, "length": 1251, "protein_name": "Negative elongation factor A", "gene_name": "Nelf-A", "organism": "Fruit fly", "refseq_name": "negative elongation factor A, isoform A", "refseq_ac": [ { "id": "NP_650958", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650958", "type": "external" } ], "gene_names_uniprotkb": "Nelf-A; BcDNA:SD07139; CG5874; Dmel\\CG5874; Dmel_CG5874; NELF A; NELF-A; NELF; NelfA; nelf-A", "gene_names_refseq": "BcDNA:SD07139; CG5874; Dmel\\CG5874; NELF A; NELF-A; NELF; Nelf-A; NelfA; nelf-A", "protein_names_uniprotkb": "Negative elongation factor A", "protein_names_refseq": "CG5874-PA; NELF-A; Nelf-A-PA; negative elongation factor A, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5874); (R-DME-112382); (R-DME-113418); (R-DME-674695); (R-DME-6796648); (R-DME-75955)", "pathway_count": 6, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15741180;16110336;17569856;17569867;20634899;25589440;26109356;26109357;29281702", "class_list": "", "function": "Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. Has an essential role in postembryonic development., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9VDC7", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003723 RNA binding;GO:0003746 translation elongation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0017053 transcription repressor complex;GO:0005694 chromosome;GO:0032021 NELF complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0034244 negative regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q86NP2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27869-1", "uniprot_id": [ { "id": "PIMT_DROME", "url": "https://www.uniprot.org/uniprot/Q27869", "type": "external" } ], "mass": 24590.0, "length": 226, "protein_name": "Protein-L-isoaspartate(D-aspartate) O-methyltransferase", "gene_name": "Pcmt", "organism": "Fruit fly", "refseq_name": "Protein-L-isoaspartate (D-aspartate) O-methyltransferase, isoform A", "refseq_ac": [ { "id": "NP_536756", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536756", "type": "external" } ], "gene_names_uniprotkb": "Pcmt; CG2152; Dmel\\CG2152; Dmel_CG2152; PCMT; PIAM; PIMT; Pimt; dPIMT; pcmt", "gene_names_refseq": "CG2152; Dmel\\CG2152; PCMT; PIMT; Pcmt; Pimt; dPIMT; pcmt", "protein_names_uniprotkb": "Protein-L-isoaspartate(D-aspartate) O-methyltransferase; 2.1.1.77; L-isoaspartyl protein carboxyl methyltransferase; PIMT; Protein L-isoaspartyl/D-aspartyl methyltransferase; Protein-beta-aspartate methyltransferase; dPIMT", "protein_names_refseq": "CG2152-PA; Pcmt-PA; Protein-L-isoaspartate (D-aspartate) O-methyltransferase, isoform A; protein D-aspartyl, L-isoaspartyl O-methyltransferase; protein isoaspartyl methyltransferase", "tax_id": 7227, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070)", "pathway": " (dme:Dmel_CG2152); (R-DME-5676934)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;14596598;16110336;17569856;17569867;25589440;26109356;26109357;9061928", "class_list": "", "function": "Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VND1", "ec_number_list": [ { "id": "2.1.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.77", "type": "external" } ], "go_molecular_function": "GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0042742 defense response to bacterium;GO:0032259 methylation;GO:0006950 response to stress", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q27869-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q95RA8-1", "uniprot_id": [ { "id": "MOB1_DROME", "url": "https://www.uniprot.org/uniprot/Q95RA8", "type": "external" } ], "mass": 25229.0, "length": 219, "protein_name": "MOB kinase activator-like 1", "gene_name": "mats", "organism": "Fruit fly", "refseq_name": "mob as tumor suppressor, isoform B", "refseq_ac": [ { "id": "NP_001262835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262835", "type": "external" } ], "gene_names_uniprotkb": "mats; B; CG13852; DMob1; Dmel\\CG13852; Dmel_CG13852; Dmob1; MATS; Mats; Mob1; Mob; anon-WO0118547.303; dmob1", "gene_names_refseq": "CG13852; DMob1; Dmel\\CG13852; Dmob1; MATS; Mats; Mob1A/B; Mob1; Mob; anon-WO0118547.303; dmob1; mats", "protein_names_uniprotkb": "MOB kinase activator-like 1; Dmob1; Mob as tumor suppressor protein 1; Mps one binder kinase activator-like 1", "protein_names_refseq": "CG13852-PB; Mob as tumor suppressor; Mob as tumor suppresso; Mob-as-tumor-supressor; mats-PB; mob as tumor suppressor, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13852); (R-DME-2028269); (R-DME-390089); (R-DME-390098); (R-DME-390150)", "pathway_count": 5, "publication_count": 31, "publication_id_list": "10731132;12202036;12223493;12537568;12537569;12537572;12537573;12537574;12941273;12941274;14502294;14502295;14561774;15766530;15975907;16096061;16110336;17174922;17347649;17569856;17569867;17889654;18245354;18256197;19330023;19710173;19733165;19913529;25589440;26109356;26109357", "class_list": "", "function": "Coactivator of Warts (Wts) kinase in the Hippo/SWH (Sav/Wts/Hpo)signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki)oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Mats is essential for early development and is required for proper chromosomal segregation in developing embryos., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VD10", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0030295 protein kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007059 chromosome segregation;GO:0007165 signal transduction;GO:0008285 negative regulation of cell population proliferation;GO:0006915 apoptotic process;GO:0035329 hippo signaling", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q95RA8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VHB6-1", "uniprot_id": [ { "id": "MTX1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VHB6", "type": "external" } ], "mass": 37252.0, "length": 327, "protein_name": "Metaxin-1 homolog", "gene_name": "Dmel\\CG9393", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform A", "refseq_ac": [ { "id": "NP_649908", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649908", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG9393; CG9393; Dmel_CG9393", "gene_names_refseq": "CG9393; Dmel\\CG9393", "protein_names_uniprotkb": "Metaxin-1 homolog; Mitochondrial outer membrane import complex protein 1", "protein_names_refseq": "CG9393-PA; uncharacterized protein, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9393)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0001401 SAM complex;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0045040 protein insertion into mitochondrial outer membrane;GO:0015031 protein transport;GO:0070096 mitochondrial outer membrane translocase complex assembly;GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VHB6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VDD3-1", "uniprot_id": [ { "id": "SNMP1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VDD3", "type": "external" } ], "mass": 62117.0, "length": 551, "protein_name": "Sensory neuron membrane protein 1", "gene_name": "Snmp1", "organism": "Fruit fly", "refseq_name": "sensory neuron membrane protein 1, isoform B", "refseq_ac": [ { "id": "NP_001262803", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262803", "type": "external" } ], "gene_names_uniprotkb": "Snmp1; CG7000; Dmel\\CG7000; Dmel_CG7000; SNMP1; SNMP; Snmp; snmp1; snmp", "gene_names_refseq": "CG7000; Dmel\\CG7000; SNMP1; SNMP; Snmp1; Snmp; snmp1; snmp", "protein_names_uniprotkb": "Sensory neuron membrane protein 1; SNMP1Dmel", "protein_names_refseq": "CG7000-PB; Snmp1-PB; sensory neuron membrane protein 1, isoform B; sensory neuron membrane protein", "tax_id": 7227, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); atrial fibrillation (Disease Ontology:DOID:0060224); myeloid neoplasm (Disease Ontology:DOID:0070004); platelet-type bleeding disorder 10 (Disease Ontology:DOID:0111046); progressive myoclonus epilepsy 4 (Disease Ontology:DOID:0111444); dermatomyositis (Disease Ontology:DOID:10223); silicosis (Disease Ontology:DOID:10325); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); thrombotic thrombocytopenic purpura (Disease Ontology:DOID:10772); sickle cell anemia (Disease Ontology:DOID:10923); polycystic ovary syndrome (Disease Ontology:DOID:11612); morbid obesity (Disease Ontology:DOID:11981); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); granulomatosis with polyangiitis (Disease Ontology:DOID:12132); malaria (Disease Ontology:DOID:12365); hemolytic-uremic syndrome (Disease Ontology:DOID:12554); atherosclerosis (Disease Ontology:DOID:1936); blood platelet disease (Disease Ontology:DOID:2218); essential thrombocythemia (Disease Ontology:DOID:2224); arteriosclerosis (Disease Ontology:DOID:2349); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); nephrosis (Disease Ontology:DOID:2527); endometriosis (Disease Ontology:DOID:289); pulmonary tuberculosis (Disease Ontology:DOID:2957); inclusion body myositis (Disease Ontology:DOID:3429); pulmonary fibrosis (Disease Ontology:DOID:3770); macular degeneration (Disease Ontology:DOID:4448); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844); osteoarthritis (Disease Ontology:DOID:8398); chronic myeloid leukemia (Disease Ontology:DOID:8552); progressive myoclonus epilepsy (Disease Ontology:DOID:891); polycythemia vera (Disease Ontology:DOID:8997); pemphigus (Disease Ontology:DOID:9182); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG7000); (R-DME-114608); (R-DME-1236973); (R-DME-434313); (R-DME-6798695)", "pathway_count": 5, "publication_count": 15, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;17943085;18653762;19364529;21948708;25589440;26109356;26109357", "class_list": "", "function": "Plays an olfactory role that is not restricted to pheromone sensitivity. Has a role in detection and signal transduction of the fatty-acid-derived male pheromone 11-cis vaccenyl acetate (cVA). Not required for sensitivity to general odorants. Acts in concert with Or67d and lush to capture cVA molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex. Essential for the electrophysiological responses of these olfactory sensory neurons (OSNs) to cVA. Not required for the development of trichoid OSNs and support cells., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 37, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A5JS49;A5JS50;A5YWL9", "ec_number_list": [], "go_molecular_function": "GO:0005044 scavenger receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0016020 membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0055088 lipid homeostasis;GO:0019236 response to pheromone;GO:0050911 detection of chemical stimulus involved in sensory perception of smell;GO:0071444 cellular response to pheromone", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9VDD3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03720-1", "uniprot_id": [ { "id": "SLO_DROME", "url": "https://www.uniprot.org/uniprot/Q03720", "type": "external" } ], "mass": 133102.0, "length": 1200, "protein_name": "Calcium-activated potassium channel slowpoke", "gene_name": "slo", "organism": "Fruit fly", "refseq_name": "slowpoke, isoform Q", "refseq_ac": [ { "id": "NP_001014651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014651", "type": "external" } ], "gene_names_uniprotkb": "slo; BcDNA:GH10751; CG10693; Dmel\\CG10693; Dmel_CG10693; Dslo; SLO; Slo1; Slo; dSlo1; dSlo; dslo; fSlo", "gene_names_refseq": "BcDNA:GH10751; CG10693; Dmel\\CG10693; Dslo; SLO; Slo1; Slo; dSlo1; dSlo; dslo; fSlo; slo", "protein_names_uniprotkb": "Calcium-activated potassium channel slowpoke; BK channel; Maxi K channel; MaxiK; dSlo", "protein_names_refseq": "CG10693-PQ; slo-PQ; slowpoke, isoform Q; slowpoke", "tax_id": 7227, "disease": "withdrawal disorder (Disease Ontology:DOID:0060001); paroxysmal nonkinesigenic dyskinesia 3 (Disease Ontology:DOID:0070442); spermatogenic failure 79 (Disease Ontology:DOID:0070578); heart conduction disease (Disease Ontology:DOID:10273); Alzheimer's disease (Disease Ontology:DOID:10652); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); alcohol use disorder (Disease Ontology:DOID:1574); generalized epilepsy (Disease Ontology:DOID:1827); substance-related disorder (Disease Ontology:DOID:303)", "pathway": " (dme:Dmel_CG10693); (R-DME-1300642)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "10230800;10234050;10731132;11274367;12019304;12537568;12537569;12537572;12537573;12537574;1497890;16110336;17569856;17569867;1857984;25589440;26109356;26109357;7666207;8774450;9502797;9539129", "class_list": "", "function": "Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Kinetics are determined by alternative splicing, phosphorylation status and its combination interaction with Slob and 14-3-3-zeta. While the interaction with Slob1 alone increases its activity, its interaction with both Slob1 and 14-3-3-zeta decreases its activity., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V3D4;Q24369;Q24384;Q24385;Q59DU0;Q59DU1;Q59DU2;Q59DU3;Q59DU4;Q59DU5;Q59DU6;Q59DU7;Q59DU8;Q59DU9;Q59DV0;Q59DV1;Q59DV2;Q7JP74;Q7KS13;Q86NK5;Q8IMV9;Q9TWA1;Q9VC51", "ec_number_list": [], "go_molecular_function": "GO:0015269 calcium-activated potassium channel activity;GO:0060072 large conductance calcium-activated potassium channel activity;GO:0046872 metal ion binding;GO:0005267 potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043025 neuronal cell body;GO:0045211 postsynaptic membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007623 circadian rhythm;GO:0006813 potassium ion transport;GO:0009410 response to xenobiotic stimulus;GO:0071805 potassium ion transmembrane transport;GO:0048512 circadian behavior", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q03720-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01989-1", "uniprot_id": [ { "id": "MYS9_DROME", "url": "https://www.uniprot.org/uniprot/Q01989", "type": "external" } ], "mass": 143299.0, "length": 1253, "protein_name": "Myosin heavy chain 95F", "gene_name": "jar", "organism": "Fruit fly", "refseq_name": "jaguar, isoform K", "refseq_ac": [ { "id": "NP_001014647", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014647", "type": "external" } ], "gene_names_uniprotkb": "jar; 95F MHC; 95F; CG5695; Dm 95F; Dm95F; Dmel\\CG5695; Dmel_CG5695; Dro95F; JAG; Jaguar; Jar; M6; MHC95F; MYOVI; Mhc95F; Myo1A; MyoVI; Myosin VI; dMyo6; dMyoVI; jag; ms(3)06746; myo VI; myo6; myoVI; myosins VI", "gene_names_refseq": "95F MHC; 95F; CG5695; Dm 95F; Dm95F; Dmel\\CG5695; Dro95F; JAG; Jaguar; Jar; M6; MHC95F; MYOVI; Mhc95F; Myo1A; MyoVI; Myosin VI; dMyo6; dMyoVI; jag; jar; ms(3)06746; myo VI; myo6; myoVI; myosins VI", "protein_names_uniprotkb": "Myosin heavy chain 95F; 95F MHC; Protein jaguar", "protein_names_refseq": "95F myosin; 95F unconventional myosin; CG5695-PK; jaguar, isoform K; jaguar; jar-PK; myosin 95F; myosin VI; myosin heavy chain at 95F; myosin heavy chain; myosin-VI; unconventional myosin VI", "tax_id": 7227, "disease": "autosomal recessive nonsyndromic deafness 37 (Disease Ontology:DOID:0110495); autosomal dominant nonsyndromic deafness 22 (Disease Ontology:DOID:0110552); sensorineural hearing loss (Disease Ontology:DOID:10003); prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); ovarian cancer (Disease Ontology:DOID:2394)", "pathway": " (dme:Dmel_CG5695); (R-DME-190873); (R-DME-9013418); (R-DME-9013420); (R-DME-9013422)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;1429838;16110336;17569856;17569867;25589440;26109356;26109357;9472041", "class_list": "", "function": "Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. Together CLIP-190 and jar may coordinate the interaction between the actin and microtubule cytoskeleton. May link endocytic vesicles to microtubules and may be involved in transport in the early embryo and in the dynamic process of dorsal closure. It is believed that its function changes during the life cycle., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V3C6;Q59DV3;Q59DV4;Q9VCA4", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0015629 actin cytoskeleton;GO:0030426 growth cone", "go_biological_process": "GO:0047497 mitochondrion transport along microtubule;GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0032956 regulation of actin cytoskeleton organization;GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q01989-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VC35-1", "uniprot_id": [ { "id": "LILI_DROME", "url": "https://www.uniprot.org/uniprot/Q9VC35", "type": "external" } ], "mass": 59993.0, "length": 527, "protein_name": "Protein Lilipod", "gene_name": "lili", "organism": "Fruit fly", "refseq_name": "lilipod, isoform A", "refseq_ac": [ { "id": "NP_651290", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651290", "type": "external" } ], "gene_names_uniprotkb": "lili; BcDNA:GH12663; CG5807; Dmel\\CG5807; Dmel_CG5807; anon-WO0118547.355", "gene_names_refseq": "BcDNA:GH12663; CG5807; Dmel\\CG5807; anon-WO0118547.355; lili", "protein_names_uniprotkb": "Protein Lilipod", "protein_names_refseq": "CG5807-PA; LIMR-like promoter of ovarian dpp; lili-PA; lilipod, isoform A; lilipod", "tax_id": 7227, "disease": "acheiropody (Disease Ontology:DOID:0050603); preaxial polydactyly II (Disease Ontology:DOID:0060986); bone development disease (Disease Ontology:DOID:0080006); Laurin-Sandrow syndrome (Disease Ontology:DOID:0111350); hypoplastic or aplastic tibia with polydactyly (Disease Ontology:DOID:0111564); syndactyly type 4 (Disease Ontology:DOID:0111818)", "pathway": " (dme:Dmel_CG5807)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;10731138;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;26512105", "class_list": "", "function": "Required during oogenesis to promote self-renewal of germline stem cells, probably by enhancing BMP signaling activity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q86PC4;Q9XZ04", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0030513 positive regulation of BMP signaling pathway;GO:0048477 oogenesis;GO:0036099 female germ-line stem cell population maintenance", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VC35-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VEW2-1", "uniprot_id": [ { "id": "SERFL_DROME", "url": "https://www.uniprot.org/uniprot/Q9VEW2", "type": "external" } ], "mass": 6885.0, "length": 60, "protein_name": "Putative SERF-like protein", "gene_name": "BcDNA:AT19233", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform C", "refseq_ac": [ { "id": "NP_001262630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262630", "type": "external" } ], "gene_names_uniprotkb": "BcDNA:AT19233; CG17931; Dmel\\CG17931; Dmel_CG17931; Hero7", "gene_names_refseq": "BcDNA:AT19233; CG17931; Dmel\\CG17931; Hero7", "protein_names_uniprotkb": "Putative SERF-like protein", "protein_names_refseq": "CG17931-PC; uncharacterized protein, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17931)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8A432", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VEW2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VEK6-1", "uniprot_id": [ { "id": "SUR8_DROME", "url": "https://www.uniprot.org/uniprot/Q9VEK6", "type": "external" } ], "mass": 69372.0, "length": 641, "protein_name": "Leucine-rich repeat protein soc-2 homolog", "gene_name": "Sur-8", "organism": "Fruit fly", "refseq_name": "Sur-8, isoform F", "refseq_ac": [ { "id": "NP_001262664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262664", "type": "external" } ], "gene_names_uniprotkb": "Sur-8; CG5407; CT17146; Dmel\\CG5407; Dmel_CG5407; SUR-8; Sur8", "gene_names_refseq": "CG5407; CT17146; Dmel\\CG5407; SUR-8; Sur-8; Sur8", "protein_names_uniprotkb": "Leucine-rich repeat protein soc-2 homolog; Protein Sur-8 homolog; Protein soc-2 homolog", "protein_names_refseq": "CG5407-PF; Sur-8, isoform F; Sur-8-PF", "tax_id": 7227, "disease": "RASopathy (Disease Ontology:DOID:0080690); Noonan syndrome-like disorder with loose anagen hair (Disease Ontology:DOID:0080691); Noonan syndrome-like disorder with loose anagen hair 1 (Disease Ontology:DOID:0080692); atopic dermatitis (Disease Ontology:DOID:3310)", "pathway": " (dme:Dmel_CG5407); (R-DME-5223345)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10731132;11741918;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Acts as a Ras effector and participates in MAPK pathway activation. Probably acts as a regulatory subunit of protein phosphatase that specifically dephosphorylates Raf kinase and stimulate Raf activity at specialized signaling complexes upon Ras activation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q86PB5;Q8MQM0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VEK6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q95R48-1", "uniprot_id": [ { "id": "OCTL_DROME", "url": "https://www.uniprot.org/uniprot/Q95R48", "type": "external" } ], "mass": 63167.0, "length": 567, "protein_name": "Organic cation transporter-like protein", "gene_name": "Orct2", "organism": "Fruit fly", "refseq_name": "organic cation transporter 2, isoform B", "refseq_ac": [ { "id": "NP_001262907", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262907", "type": "external" } ], "gene_names_uniprotkb": "Orct2; CG13610; Dmel\\CG13610; Dmel_CG13610; EP(3)1072; EP1072; cald; orct2", "gene_names_refseq": "CG13610; Dmel\\CG13610; EP(3)1072; EP1072; Orct2; cald; orct2", "protein_names_uniprotkb": "Organic cation transporter-like protein", "protein_names_refseq": "CG13610-PB; EP1072; Orct2-PB; calderon; organic cation transporter 2, isoform B", "tax_id": 7227, "disease": "kidney failure (Disease Ontology:DOID:1074); extrahepatic cholestasis (Disease Ontology:DOID:13619); systemic primary carnitine deficiency disease (Disease Ontology:DOID:14365); intrahepatic cholestasis (Disease Ontology:DOID:1852); hyperuricemia (Disease Ontology:DOID:1920); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (dme:Dmel_CG13610); (R-DME-112311); (R-DME-181430); (R-DME-196807); (R-DME-200425); (R-DME-2161517); (R-DME-442660); (R-DME-549127); (R-DME-561048); (R-DME-917937); (R-DME-9749641); (R-DME-9793528)", "pathway_count": 12, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Probably transports organic cations., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9VCA3", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0015695 organic cation transport;GO:0006811 monoatomic ion transport;GO:0030307 positive regulation of cell growth;GO:0040018 positive regulation of multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q95R48-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V3P6-1", "uniprot_id": [ { "id": "PSMD1_DROME", "url": "https://www.uniprot.org/uniprot/Q9V3P6", "type": "external" } ], "mass": 113199.0, "length": 1020, "protein_name": "26S proteasome non-ATPase regulatory subunit 1", "gene_name": "Rpn2", "organism": "Fruit fly", "refseq_name": "regulatory particle non-ATPase 2, isoform C", "refseq_ac": [ { "id": "NP_001263058", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263058", "type": "external" } ], "gene_names_uniprotkb": "Rpn2; 11888; CG11888; Dmel\\CG11888; Dmel_CG11888; PSMC1; RPN2; S1; dRpn2; p110; rpn2", "gene_names_refseq": "11888; CG11888; Dmel\\CG11888; PSMC1; RPN2; Rpn2; S1; dRpn2; p110; rpn2", "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 1; 26S proteasome regulatory complex subunit p110; 26S proteasome regulatory subunit RPN2", "protein_names_refseq": "CG11888-PC; Rpn2-PC; regulatory particle non-ATPase 2, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11888); (R-DME-1169091); (R-DME-1234176); (R-DME-1236978); (R-DME-174084); (R-DME-174154); (R-DME-174178); (R-DME-174184); (R-DME-187577); (R-DME-195253); (R-DME-202424); (R-DME-209360); (R-DME-209406); (R-DME-209461); (R-DME-216167); (R-DME-2467813); (R-DME-2871837); (R-DME-350562); (R-DME-382556); (R-DME-432395); (R-DME-432524); (R-DME-432626); (R-DME-450408); (R-DME-4608870); (R-DME-4641257); (R-DME-4641258); (R-DME-5358346); (R-DME-538864); (R-DME-5607761); (R-DME-5607764); (R-DME-5610780); (R-DME-5610785); (R-DME-5632684); (R-DME-5658442); (R-DME-5676590); (R-DME-5689603); (R-DME-5689880); (R-DME-6798695); (R-DME-68867); (R-DME-68949); (R-DME-69017); (R-DME-69601); (R-DME-75815); (R-DME-8854050); (R-DME-8939236); (R-DME-8939902); (R-DME-8941858); (R-DME-8948751); (R-DME-8951664); (R-DME-9020702); (R-DME-9755511); (R-DME-9762114); (R-DME-983168); (R-DME-9907900); (R-DME-9929491); (R-DME-9932298); (R-DME-9954709)", "pathway_count": 57, "publication_count": 47, "publication_id_list": "10102270;10417378;10458606;10481010;10731132;10893261;11157774;11585911;12231619;12432393;12442174;12537568;12537569;12537572;12537573;12537574;12973300;15178801;15258584;15331761;16110336;16139204;16299518;16326393;16386907;16543224;16603629;16651542;16740475;16794082;17102630;17569856;17569867;17925225;18327897;18519643;18593878;19185492;25589440;26109356;26109357;7705656;8948598;9025065;9215627;9553105;9990853", "class_list": "", "function": "Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins., [UniProtKB, PubMed]; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B5RIH8;Q8IGU4;Q8T075;Q9GSE5;Q9GU70", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0034515 proteasome storage granule;GO:0008540 proteasome regulatory particle, base subcomplex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0042176 regulation of protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 4.8, "record_id": "Q9V3P6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VC27-1", "uniprot_id": [ { "id": "NICA_DROME", "url": "https://www.uniprot.org/uniprot/Q9VC27", "type": "external" } ], "mass": 77993.0, "length": 695, "protein_name": "Nicastrin", "gene_name": "Nct", "organism": "Fruit fly", "refseq_name": "nicastrin, isoform C", "refseq_ac": [ { "id": "NP_001163713", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163713", "type": "external" } ], "gene_names_uniprotkb": "Nct; CG7012; Dmel\\CG7012; Dmel_CG7012; NCSTN; Nic; S5A; ST96B; agro; dNct; nct; nic", "gene_names_refseq": "CG7012; Dmel\\CG7012; Nct; Nic; S5A; ST96B; agro; dNct; nct; nic", "protein_names_uniprotkb": "Nicastrin", "protein_names_refseq": "CG7012-PC; Nct-PC; agoraphobic; dNicastrin; nicastrin, isoform C; nicastrin", "tax_id": 7227, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); vitiligo (Disease Ontology:DOID:12306); alcohol use disorder (Disease Ontology:DOID:1574); hidradenitis suppurativa (Disease Ontology:DOID:2280); schizophrenia (Disease Ontology:DOID:5419); chronic myeloid leukemia (Disease Ontology:DOID:8552)", "pathway": " (dme:Dmel_CG7012); (R-DME-1251985); (R-DME-3928665); (R-DME-6798695)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "10731132;10993067;11781576;11782315;11782316;12537568;12537572;12537573;12537574;12660785;16110336;17569856;17569867;25589440;26109356;26109357;40245499", "class_list": "", "function": "Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0055037 recycling endosome;GO:0005770 late endosome;GO:0070765 gamma-secretase complex", "go_biological_process": "GO:0046331 lateral inhibition;GO:0035333 Notch receptor processing, ligand-dependent;GO:0006509 membrane protein ectodomain proteolysis;GO:0007219 Notch signaling pathway;GO:0007220 Notch receptor processing", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9VC27-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24167-1", "uniprot_id": [ { "id": "SIMA_DROME", "url": "https://www.uniprot.org/uniprot/Q24167", "type": "external" } ], "mass": 165824.0, "length": 1507, "protein_name": "Protein similar", "gene_name": "sima", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_524584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524584", "type": "external" } ], "gene_names_uniprotkb": "sima; 7951; CG31031; CG45051; CG7951; DMU43090; Dmel\\CG45051; Dmel_CG45051; HIF alpha; HIF-1alpha; HIF-1a; HIF-1; HIF1A; HIF1alpha; HIF1; HIFalpha; Hif-1A; Hif1alpha; Hifalpha; SIMA; Sima; bHLHe56; dHIF-1alpha; dHIF-alpha; hif; l(3)j11B7; sima", "gene_names_refseq": "7951; CG31031; CG45051; CG7951; DMU43090; Dmel\\CG45051; HIF alpha; HIF-1alpha; HIF-1a; HIF-1; HIF-alpha/sima; HIF1A; HIF1alpha; HIF1; HIFalpha; Hif-1A; Hif1alpha; Hifalpha; SIMA; Sima; bHLHe56; dHIF-1alpha; dHIF-alpha; hif; l(3)j11B7; sima", "protein_names_uniprotkb": "Protein similar", "protein_names_refseq": "uncharacterized protein", "tax_id": 7227, "disease": "limb ischemia (Disease Ontology:DOID:0050852); ductal carcinoma in situ (Disease Ontology:DOID:0060074); atrial fibrillation (Disease Ontology:DOID:0060224); alcohol-associated liver disease (Disease Ontology:DOID:0070658); polycystic kidney disease (Disease Ontology:DOID:0080322); familial erythrocytosis 4 (Disease Ontology:DOID:0080339); osteonecrosis (Disease Ontology:DOID:10159); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); kidney failure (Disease Ontology:DOID:1074); hypertension (Disease Ontology:DOID:10763); cholesteatoma of middle ear (Disease Ontology:DOID:10964); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); glycogen storage disease VII (Disease Ontology:DOID:11721); morbid obesity (Disease Ontology:DOID:11981); varicocele (Disease Ontology:DOID:12337); retinal ischemia (Disease Ontology:DOID:12510); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); hepatic encephalopathy (Disease Ontology:DOID:13413); bladder neck obstruction (Disease Ontology:DOID:13948); interstitial cystitis (Disease Ontology:DOID:13949); von Hippel-Lindau disease (Disease Ontology:DOID:14175); cancer (Disease Ontology:DOID:162); nephroblastoma (Disease Ontology:DOID:2154); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); glycogen storage disease V (Disease Ontology:DOID:2746); invasive ductal carcinoma (Disease Ontology:DOID:3008); acute kidney failure (Disease Ontology:DOID:3021); brain infarction (Disease Ontology:DOID:3454); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); intermittent claudication (Disease Ontology:DOID:3669); olfactory neuroblastoma (Disease Ontology:DOID:369); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hyperglycemia (Disease Ontology:DOID:4195); macular retinal edema (Disease Ontology:DOID:4449); renal cell carcinoma (Disease Ontology:DOID:4450); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); osteoarthritis (Disease Ontology:DOID:8398); polycythemia (Disease Ontology:DOID:8432); mycosis fungoides (Disease Ontology:DOID:8691); decubitus ulcer (Disease Ontology:DOID:8717); psoriasis (Disease Ontology:DOID:8893); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG45051); (R-DME-1234158); (R-DME-1234176); (R-DME-8951664)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "10731132;11006129;12215541;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8682312;9731218", "class_list": "", "function": "Functions as a transcriptional regulator of the adaptive response to hypoxia. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 56, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9VAA5", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005667 transcription regulator complex;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0032869 cellular response to insulin stimulus;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q24167-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05652-1", "uniprot_id": [ { "id": "KPEL_DROME", "url": "https://www.uniprot.org/uniprot/Q05652", "type": "external" } ], "mass": 56160.0, "length": 501, "protein_name": "Serine/threonine-protein kinase pelle", "gene_name": "pll", "organism": "Fruit fly", "refseq_name": "pelle, isoform B", "refseq_ac": [ { "id": "NP_001263008", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263008", "type": "external" } ], "gene_names_uniprotkb": "pll; CG5974; Dmel\\CG5974; Dmel_CG5974; IL-1; IRAK1; PELLE; Pelle; Pll; p11", "gene_names_refseq": "CG5974; Dmel\\CG5974; PELLE/IL-1; PELLE; Pelle; Pll; p11; pll/IRAK1; pll", "protein_names_uniprotkb": "Serine/threonine-protein kinase pelle; 2.7.11.1", "protein_names_refseq": "CG5974-PB; Serine/threonine-protein kinase pelle; pelle, isoform B; pll-PB", "tax_id": 7227, "disease": "osteoporosis (Disease Ontology:DOID:11476); cognitive disorder (Disease Ontology:DOID:1561); diffuse scleroderma (Disease Ontology:DOID:1580); squamous cell carcinoma (Disease Ontology:DOID:1749); maxillary sinusitis (Disease Ontology:DOID:2051); brain ischemia (Disease Ontology:DOID:2316); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); tuberculosis (Disease Ontology:DOID:399); allergic rhinitis (Disease Ontology:DOID:4481); melioidosis (Disease Ontology:DOID:5052); primary immunodeficiency disease (Disease Ontology:DOID:612); ankylosing spondylitis (Disease Ontology:DOID:7147); psoriasis (Disease Ontology:DOID:8893); psoriatic arthritis (Disease Ontology:DOID:9008); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dme:Dmel_CG5974); (R-DME-214842); (R-DME-214844); (R-DME-214862); (R-DME-214869); (R-DME-214874); (R-DME-445989); (R-DME-450302); (R-DME-450321); (R-DME-9020702); (R-DME-937039); (R-DME-937042); (R-DME-937072); (R-DME-975144); (R-DME-975163)", "pathway_count": 15, "publication_count": 27, "publication_id_list": "10072384;10330490;10589682;10660298;10731132;11532919;11934858;12537568;12537569;12537572;12537573;12537574;14685264;16110336;16782008;17569856;17569867;25589440;26109356;26109357;7527496;7635064;8440018;8948598;9367441;9405646;9806920", "class_list": "", "function": "Plays an essential role in the Tl receptor signaling pathway that establishes embryonic dorsoventral polarity; the signal directs import of dl into ventral and ventrolateral nuclei, thereby establishing dorsoventral polarity. Tub recruits pll to the plasma membrane and protein-protein interaction activates pll., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8A3X2;Q8T005;Q9VB57", "ec_number_list": [ { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "5.6.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.8", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019904 protein domain specific binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0045087 innate immune response;GO:0006915 apoptotic process;GO:0045732 positive regulation of protein catabolic process;GO:0009953 dorsal/ventral pattern formation", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q05652-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VDG2-1", "uniprot_id": [ { "id": "RLIP_DROME", "url": "https://www.uniprot.org/uniprot/Q9VDG2", "type": "external" } ], "mass": 71896.0, "length": 625, "protein_name": "RalA-binding protein 1", "gene_name": "Rlip", "organism": "Fruit fly", "refseq_name": "Ral interacting protein, isoform A", "refseq_ac": [ { "id": "NP_650933", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650933", "type": "external" } ], "gene_names_uniprotkb": "Rlip; CG11622; D-RLIP; DRLIP; Dmel\\CG11622; Dmel_CG11622; RLIP1; RLIP; RalBP1; RhoGAP-93B3; dRLIP; dRalBP; dRlip", "gene_names_refseq": "CG11622; D-RLIP; DRLIP; Dmel\\CG11622; RLIP1; RLIP; RalBP1; RhoGAP-93B3; Rlip; dRLIP; dRalBP; dRlip", "protein_names_uniprotkb": "RalA-binding protein 1; Ral-interacting protein 1; RalBP1", "protein_names_refseq": "CG11622-PA; Ral interacting protein, isoform A; Rlip-PA", "tax_id": 7227, "disease": "microphthalmia (Disease Ontology:DOID:10629); urinary bladder cancer (Disease Ontology:DOID:11054); pancreatic adenocarcinoma (Disease Ontology:DOID:4074)", "pathway": " (dme:Dmel_CG11622); (R-DME-9013148); (R-DME-9013149)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;12775724;16110336;17018572;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Participates in receptor endocytosis during interphase, is also involved in mitotic processes when endocytosis is switched off., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O96392;Q8MZ58", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction;GO:0006898 receptor-mediated endocytosis;GO:0046578 regulation of Ras protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9VDG2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VD28-1", "uniprot_id": [ { "id": "JMJD6_DROME", "url": "https://www.uniprot.org/uniprot/Q9VD28", "type": "external" } ], "mass": 47006.0, "length": 408, "protein_name": "Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6", "gene_name": "JMJD6", "organism": "Fruit fly", "refseq_name": "jumonji domain containing 6, isoform A", "refseq_ac": [ { "id": "NP_651026", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651026", "type": "external" } ], "gene_names_uniprotkb": "JMJD6; BEST:LD22859; CG5383; Dmel\\CG5383; Dmel_CG5383; L0022859; PSR; PS; Psr; dPSR; psr", "gene_names_refseq": "BEST:LD22859; CG5383; Dmel\\CG5383; JMJD6; L0022859; PSR; PS; Psr; dPSR; psr", "protein_names_uniprotkb": "Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; 1.14.11.-; Jumonji domain-containing protein 6; Phosphatidylserine receptor; dPSR", "protein_names_refseq": "CG5383-PA; JMJD6-PA; jumonji domain containing 6, isoform A; phosphatidyl-serine receptor; phosphatidylserine receptor", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5383); (R-DME-3214842); (R-DME-9629569)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17522160;17569856;17569867;25589440;26109356;26109357;28701701;29339751", "class_list": "", "function": "Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase (By similarity). Negative regulator of apoptosis; functions upstream of hid possibly by acting on the JNK signaling pathway (PubMed:17522160). Not required for apoptotic cell clearance by macrophages in the developing embryo (PubMed:17522160). May be involved in regulation of chromatin structure, promoting expansion of euchromatin (PubMed:28701701). May be involved in regulation of behavior and circadian rhythms (PubMed:29339751)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" } ], "go_molecular_function": "GO:0033746 histone H3R2 demethylase activity;GO:0033749 histone H4R3 demethylase activity;GO:0070815 peptidyl-lysine 5-dioxygenase activity;GO:0046872 metal ion binding;GO:0106140 P-TEFb complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0018395 peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine;GO:0006351 DNA-templated transcription;GO:0043066 negative regulation of apoptotic process;GO:0006909 phagocytosis;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9VD28-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V9V9-1", "uniprot_id": [ { "id": "NAT9_DROME", "url": "https://www.uniprot.org/uniprot/Q9V9V9", "type": "external" } ], "mass": 23629.0, "length": 200, "protein_name": "Alpha/beta-tubulin-N-acetyltransferase 9", "gene_name": "Mnat9", "organism": "Fruit fly", "refseq_name": "microtubule-associated Nat9, isoform B", "refseq_ac": [ { "id": "NP_001263148", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263148", "type": "external" } ], "gene_names_uniprotkb": "Mnat9; CG11539; Dmel\\CG11539; Dmel_CG11539; NAT9", "gene_names_refseq": "CG11539; Dmel\\CG11539; Mnat9; NAT9", "protein_names_uniprotkb": "Alpha/beta-tubulin-N-acetyltransferase 9; 2.3.1.308; Microtubule-associated Nat9", "protein_names_refseq": "CG11539-PB; Mnat9-PB; microtubule-associated Nat9, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11539)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;33479178", "class_list": "", "function": "N-acetyltransferase that mediates the acetylation of the N-terminal residues of alpha- and beta-tubulin (PubMed:33479178). Required for microtubule stability and inhibition of JNK signaling to promote cell survival during development, possibly acting independently of its N-acetyltransferase activity (PubMed:33479178). Necessary for the stabilization of spindle microtubules and for mitosis progression (PubMed:33479178). Regulates microtubule stability by inhibiting Spastin-mediated depolymerization and promoting Eb1-mediated polymerization (PubMed:33479178)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.255", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.255", "type": "external" }, { "id": "2.3.1.308", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.308", "type": "external" } ], "go_molecular_function": "GO:0008017 microtubule binding;GO:0120519 tubulin N-terminal-methionine acetyltransferase activity;GO:0004596 protein-N-terminal amino-acid acetyltransferase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus", "go_biological_process": "GO:0007026 negative regulation of microtubule depolymerization;GO:0031116 positive regulation of microtubule polymerization;GO:0046329 negative regulation of JNK cascade;GO:0035331 negative regulation of hippo signaling;GO:1901673 regulation of mitotic spindle assembly", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9V9V9-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VBP3-1", "uniprot_id": [ { "id": "TNKS_DROME", "url": "https://www.uniprot.org/uniprot/Q9VBP3", "type": "external" } ], "mass": 127945.0, "length": 1181, "protein_name": "Poly [ADP-ribose] polymerase tankyrase", "gene_name": "Tnks", "organism": "Fruit fly", "refseq_name": "tankyrase, isoform A", "refseq_ac": [ { "id": "NP_651410", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651410", "type": "external" } ], "gene_names_uniprotkb": "Tnks; BcDNA:LD22548; CG17487; CG4719; DTNKS; Dm.pARTb; Dmel\\CG4719; Dmel_CG4719; TNKS; Tankyrase; TkrsIR; dARTD5; dTANK; dTNKS; tankyrase", "gene_names_refseq": "BcDNA:LD22548; CG17487; CG4719; DTNKS; Dm.pARTb; Dmel\\CG4719; TNKS; Tankyrase; TkrsIR; Tnks; dARTD5; dTANK; dTNKS", "protein_names_uniprotkb": "Poly [ADP-ribose] polymerase tankyrase; 2.4.2.-; 2.4.2.30; Poly [ADP-ribose] polymerase; Protein poly-ADP-ribosyltransferase tankyrase; dTNKS", "protein_names_refseq": "CG4719-PA; Tnks-PA; dTankyrase; tankyrase, isoform A; tankyrase", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4719); (R-DME-4641257); (R-DME-8948751)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10731132;10731138;12537568;12537572;12537573;12537574;16110336;17569856;17569867;23622245;25589440;26109356;26109357", "class_list": "", "function": "Stimulates proteasome activity, probably by ADP-ribosylation of PI31 (PubMed:23622245). Modulates 26S proteasome assembly (PubMed:23622245)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9XZ37", "ec_number_list": [ { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "5.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.5", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity;GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity;GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046330 positive regulation of JNK cascade;GO:0070198 protein localization to chromosome, telomeric region;GO:0045732 positive regulation of protein catabolic process;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VBP3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V9Y9-1", "uniprot_id": [ { "id": "SPNF_DROME", "url": "https://www.uniprot.org/uniprot/Q9V9Y9", "type": "external" } ], "mass": 40907.0, "length": 364, "protein_name": "Protein spindle-F", "gene_name": "spn-F", "organism": "Fruit fly", "refseq_name": "spn-F, isoform A", "refseq_ac": [ { "id": "NP_651858", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651858", "type": "external" } ], "gene_names_uniprotkb": "spn-F; 03; CG12114; Dmel\\CG12114; Dmel_CG12114; Spn-F; SpnF; l(3)S113003b", "gene_names_refseq": "1130/03; CG12114; Dmel\\CG12114; Spn-F; SpnF; l(3)S113003b; spn-F", "protein_names_uniprotkb": "Protein spindle-F", "protein_names_refseq": "CG12114-PA; Spindle-F; lethal (3) S113003b; spindle F; spn-F, isoform A; spn-F-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12114)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;16540510;17569856;17569867;18796167;19917727;24019068;25589440;26092846;26109356;26109357;26540204", "class_list": "", "function": "Plays a role in oocyte axis determination and microtubule organization during oogenesis (PubMed:16540510, PubMed:24019068). Also required for polarized organization of the bristle (PubMed:19917727). Required, with jvl, for activation of the kinase IKKepsilon in the germ line (PubMed:24019068). Also required for localization of IKKepsilon to the distal tip of elongating bristles by acting as an adapter linking IKKepsilon and cytoplasmic dynein (PubMed:26092846). Involved in dendrite pruning in larval sensory neurons during metamorphosis (PubMed:26540204)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005856 cytoskeleton;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0007399 nervous system development;GO:0008104 intracellular protein localization;GO:0007309 oocyte axis specification;GO:0007314 oocyte anterior/posterior axis specification;GO:0007317 regulation of pole plasm oskar mRNA localization", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9V9Y9-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0E9F2-1", "uniprot_id": [ { "id": "Q0E9F2_DROME", "url": "https://www.uniprot.org/uniprot/Q0E9F2", "type": "external" } ], "mass": 168236.0, "length": 1542, "protein_name": "Sticks and stones, isoform B", "gene_name": "sns", "organism": "Fruit fly", "refseq_name": "sticks and stones, isoform B", "refseq_ac": [ { "id": "NP_001036532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036532", "type": "external" } ], "gene_names_uniprotkb": "sns; 43-49; CG12495; CG13752; CG13753; CG13754; CG13755; CG18464; CG2385; CG33141; CG8278; CT33230; CT33232; Dmel\\CG33141; Dmel_CG33141; SNS; SnS; Sns; rost; sns20", "gene_names_refseq": "43-49; CG12495; CG13752; CG13753; CG13754; CG13755; CG18464; CG2385; CG33141; CG8278; CT33230; CT33232; Dmel\\CG33141; SNS; SnS; Sns; rost; sns20; sns", "protein_names_uniprotkb": "Sticks and stones, isoform B", "protein_names_refseq": "CG33141-PB; nephrin; sns-PB; stick-and-stones; sticks and stones, isoform B; sticks and stones; sticks and stone; sticks-and-stones", "tax_id": 7227, "disease": "nephrotic syndrome type 1 (Disease Ontology:DOID:0080390); kidney failure (Disease Ontology:DOID:1074); membranous glomerulonephritis (Disease Ontology:DOID:10976); nephrotic syndrome (Disease Ontology:DOID:1184); kidney disease (Disease Ontology:DOID:557); proteinuria (Disease Ontology:DOID:576); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (dme:Dmel_CG33141); (R-DME-373753)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050839 cell adhesion molecule binding;GO:0098631 cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005917 nephrocyte diaphragm;GO:0005911 cell-cell junction;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0007286 spermatid development;GO:0030036 actin cytoskeleton organization;GO:0007520 myoblast fusion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q0E9F2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V9E3-1", "uniprot_id": [ { "id": "PREP_DROME", "url": "https://www.uniprot.org/uniprot/Q9V9E3", "type": "external" } ], "mass": 119324.0, "length": 1034, "protein_name": "Presequence protease, mitochondrial", "gene_name": "Dmel\\CG3107", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform C", "refseq_ac": [ { "id": "NP_001036470", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036470", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG3107; CG3107; Dmel_CG3107", "gene_names_refseq": "CG3107; Dmel\\CG3107", "protein_names_uniprotkb": "Presequence protease, mitochondrial; 3.4.24.-", "protein_names_refseq": "CG3107-PC; uncharacterized protein, isoform C", "tax_id": 7227, "disease": "hereditary ataxia (Disease Ontology:DOID:0050951); autosomal recessive spinocerebellar ataxia 30 (Disease Ontology:DOID:0070411); Alzheimer's disease (Disease Ontology:DOID:10652); primary cerebellar degeneration (Disease Ontology:DOID:9277)", "pathway": " (dme:Dmel_CG3107); (R-DME-1268020)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4UZ44;B7YZR1;Q0E9P8", "ec_number_list": [ { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.5.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.39", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0008237 metallopeptidase activity", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0005739 mitochondrion", "go_biological_process": "GO:0006508 proteolysis;GO:0051603 proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9V9E3-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q94518-1", "uniprot_id": [ { "id": "NACA_DROME", "url": "https://www.uniprot.org/uniprot/Q94518", "type": "external" } ], "mass": 23021.0, "length": 217, "protein_name": "Nascent polypeptide-associated complex subunit alpha", "gene_name": "Nacalpha", "organism": "Fruit fly", "refseq_name": "nascent polypeptide associated complex protein alpha subunit, isoform D", "refseq_ac": [ { "id": "NP_001286363", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286363", "type": "external" } ], "gene_names_uniprotkb": "Nacalpha; CG8759; Dmel\\CG8759; Dmel_CG8759; NAC-alpha; NACalpha; NAC; aic; alpha-NAC; alphaNAC; l(2)04329; ubNACalpha", "gene_names_refseq": "CG8759; Dmel\\CG8759; NAC-alpha; NACalpha; NAC; Nacalpha; aic; alpha-NAC; alphaNAC; l(2)04329; ubNACalpha", "protein_names_uniprotkb": "Nascent polypeptide-associated complex subunit alpha; Alpha-NAC; NAC-alpha", "protein_names_refseq": "CG8759-PD; NAC protein alpha subunit; Nacalpha-PD; alpha NAC; lethal (2) 04329; nascent polypeptide associated complex protein alpha subunit, isoform D; ubiquitous NAC-alpha; ubiquitous NACalpha", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8759)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10071211;10731132;11102369;12537568;12537569;12537572;12537573;12537574;15239960;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "May promote appropriate targeting of ribosome-nascent polypeptide complexes (By similarity). Required for correct localization of the osk/oskar protein to the posterior pole during embryonic development. The osk protein directs the recruitment of molecules responsible for posterior body patterning and germline formation in the embryo., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4UZF1;O16813;Q0E999", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005854 nascent polypeptide-associated complex", "go_biological_process": "GO:0015031 protein transport;GO:0006612 protein targeting to membrane", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q94518-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01820-1", "uniprot_id": [ { "id": "GCL_DROME", "url": "https://www.uniprot.org/uniprot/Q01820", "type": "external" } ], "mass": 65152.0, "length": 569, "protein_name": "Protein germ cell-less", "gene_name": "gcl", "organism": "Fruit fly", "refseq_name": "germ cell-less, isoform A", "refseq_ac": [ { "id": "NP_724708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_724708", "type": "external" } ], "gene_names_uniprotkb": "gcl; CG8411; Dmel\\CG8411; Dmel_CG8411; GCL; Gcl; gcl-1", "gene_names_refseq": "CG8411; Dmel\\CG8411; GCL; Gcl; gcl-1; gcl", "protein_names_uniprotkb": "Protein germ cell-less", "protein_names_refseq": "CG8411-PA; gcl-PA; germ cell less; germ cell-less, isoform A; germ-cell-less", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8411)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;1380406;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Required for the specification of pole cells and germ cell formation. Mothers with reduced glc function give rise to sterile adult progeny that lack germ cells., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9V4X5", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005643 nuclear pore;GO:0005938 cell cortex;GO:0034399 nuclear periphery;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0045892 negative regulation of DNA-templated transcription;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0007281 germ cell development;GO:0000209 protein polyubiquitination;GO:0016480 negative regulation of transcription by RNA polymerase III", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q01820-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V411-1", "uniprot_id": [ { "id": "NOG1_DROME", "url": "https://www.uniprot.org/uniprot/Q9V411", "type": "external" } ], "mass": 75351.0, "length": 652, "protein_name": "Nucleolar GTP-binding protein 1", "gene_name": "Non1", "organism": "Fruit fly", "refseq_name": "putative nucleolar protein 1, isoform B", "refseq_ac": [ { "id": "NP_001286247", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286247", "type": "external" } ], "gene_names_uniprotkb": "Non1; BcDNA:LD23830; CG30341; CG8801; Dmel\\CG8801; Dmel_CG8801; LD23830", "gene_names_refseq": "BcDNA:LD23830; CG30341; CG8801; Dmel\\CG8801; LD23830; Non1", "protein_names_uniprotkb": "Nucleolar GTP-binding protein 1; Novel nucleolar protein 1", "protein_names_refseq": "CG8801-PB; Non1-PB; putative nucleolar protein 1, isoform B", "tax_id": 7227, "disease": "end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (dme:Dmel_CG8801)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;20308539;24255106;25589440;26109356;26109357;35413237;40245499", "class_list": "", "function": "Involved in the biogenesis of the 60S ribosomal subunit (By similarity). Required for normal assembly of the mitotic spindle (PubMed:24255106). May be involved in both centrosome-dependent and centrosome-independent spindle assembly programs (PubMed:24255106). Acts as a TP53 repressor, preventing TP53 stabilization and cell cycle arrest (PubMed:20308539, PubMed:35413237)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Involved in the biogenesis of the 60S ribosomal subunit., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0051301 cell division;GO:0042273 ribosomal large subunit biogenesis;GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9V411-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AWJ9-1", "uniprot_id": [ { "id": "PTK7_DROME", "url": "https://www.uniprot.org/uniprot/Q6AWJ9", "type": "external" } ], "mass": 114267.0, "length": 1033, "protein_name": "Tyrosine-protein kinase-like otk", "gene_name": "otk", "organism": "Fruit fly", "refseq_name": "off-track, isoform A", "refseq_ac": [ { "id": "NP_523705", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523705", "type": "external" } ], "gene_names_uniprotkb": "otk; CG8967; CT25769; DTKR; DTrk; Dmel\\CG8967; Dmel_CG8967; Dtkr; Dtrk; IGGtyk; OTK; Otk; TRK; Tk48D; Trk48D; anon-WO2004063362.81; dTrk", "gene_names_refseq": "CG8967; CT25769; DTKR; DTrk; Dmel\\CG8967; Dtkr; Dtrk; IGGtyk; OFT/TRK; OTK; Otk; Tk48D; Trk48D; anon-WO2004063362.81; dTrk; otk", "protein_names_uniprotkb": "Tyrosine-protein kinase-like otk; Dtrk; Gp160-Dtrk; Off-track; Tyrosine-protein kinase-like 7 homolog", "protein_names_refseq": "CG8967-PA; Off-track; off track; off-track, isoform A; offtrack; otk-PA; tyrosine kinase at 48D", "tax_id": 7227, "disease": "scoliosis (Disease Ontology:DOID:0060249); idiopathic scoliosis (Disease Ontology:DOID:0060250)", "pathway": " (dme:Dmel_CG8967); (R-DME-1474228); (R-DME-210991); (R-DME-216083); (R-DME-428542); (R-DME-433692); (R-DME-9749641)", "pathway_count": 7, "publication_count": 16, "publication_id_list": "10731132;11604138;12537568;12537572;12537573;12537574;1371458;15456725;16110336;17569856;17569867;18327897;19349973;25589440;26109356;26109357", "class_list": "", "function": "Acts as a calcium-dependent, homophilic cell adhesion molecule that regulates neural recognition during the development of the nervous system. Component of the repulsive Plexin signaling response to regulate motor axon guidance at the embryonic stage. Also component of a receptor complex that is required in the adult visual system to innervate the lamina layer; specific targeting of R1-R6 axons., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "C4IXZ4;Q24327", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0005524 ATP binding;GO:0030215 semaphorin receptor binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0007155 cell adhesion;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0060828 regulation of canonical Wnt signaling pathway;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q6AWJ9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V6K1-1", "uniprot_id": [ { "id": "TPP2_DROME", "url": "https://www.uniprot.org/uniprot/Q9V6K1", "type": "external" } ], "mass": 158737.0, "length": 1441, "protein_name": "Tripeptidyl-peptidase 2", "gene_name": "TppII", "organism": "Fruit fly", "refseq_name": "Tripeptidyl-peptidase II, isoform F", "refseq_ac": [ { "id": "NP_001286376", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286376", "type": "external" } ], "gene_names_uniprotkb": "TppII; CG3991; Dmel\\CG3991; Dmel_CG3991; TPP II; TPP2; TPPII; anon-WO0118547.127; dTPP II; dTPPII; l(2)k14301", "gene_names_refseq": "CG3991; Dmel\\CG3991; TPP II; TPP2; TPPII; TppII; anon-WO0118547.127; dTPP II; dTPPII; l(2)k14301", "protein_names_uniprotkb": "Tripeptidyl-peptidase 2; 3.4.14.10; TPP-2; TPP-II; Tripeptidyl aminopeptidase; Tripeptidyl-peptidase II; dTPP II", "protein_names_refseq": "CG3991-PF; TppII-PF; Tripeptidyl-peptidase II, isoform F; tripeptidyl peptidase II; tripeptidyl-peptidase II; tripeptidylpeptidase II", "tax_id": 7227, "disease": "primary immunodeficiency disease (Disease Ontology:DOID:612)", "pathway": " (dme:Dmel_CG3991); (R-DME-983168)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10731132;12426370;12537568;12537569;12537572;12537573;12537574;16006508;16110336;17569856;17569867;18327897;20676100;25589440;26109356;26109357;9668104", "class_list": "", "function": "Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway (By similarity). Efficiently cleaves Ala-Ala-Ala-polypeptide and Pro-Pro-Ala-polypeptide, Val-Leu-Lys-polypeptide only at high concentration. Does not cleave Ala-Phe-Pro-polypeptide nor Pro-Leu-Gly-polypeptide., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B5RJ14;O76251;Q8IH59;Q8ML58", "ec_number_list": [ { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "3.4.11.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.14", "type": "external" }, { "id": "3.4.14.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.10", "type": "external" }, { "id": "3.4.22.40", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.40", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0008240 tripeptidyl-peptidase activity;GO:0017171 serine hydrolase activity;GO:0004177 aminopeptidase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9V6K1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8T3U2-1", "uniprot_id": [ { "id": "RS23_DROME", "url": "https://www.uniprot.org/uniprot/Q8T3U2", "type": "external" } ], "mass": 16017.0, "length": 143, "protein_name": "Small ribosomal subunit protein uS12", "gene_name": "RpS23", "organism": "Fruit fly", "refseq_name": "ribosomal protein S23, isoform B", "refseq_ac": [ { "id": "NP_001286410", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286410", "type": "external" } ], "gene_names_uniprotkb": "RpS23; CG8415; CT24703; Dmel\\CG8415; Dmel_CG8415; RPS23; Rp S23; Rps23; S12; anon-EST:Posey158; anon-EST:Posey63", "gene_names_refseq": "CG8415; CT24703; Dmel\\CG8415; RPS23; Rp S23; RpS23; Rps23; S12; anon-EST:Posey158; anon-EST:Posey63", "protein_names_uniprotkb": "Small ribosomal subunit protein uS12; 40S ribosomal protein S23", "protein_names_refseq": "CG8415-PB; RpS23-PB; ribosomal protein S23, isoform B; ribosomal protein S23", "tax_id": 7227, "disease": "brachycephaly, trichomegaly, and developmental delay (Disease Ontology:DOID:0070415)", "pathway": " (dme:Dmel_CG8415); (R-DME-156827); (R-DME-1799339); (R-DME-6791226); (R-DME-72649); (R-DME-72689); (R-DME-72695); (R-DME-72702); (R-DME-72706); (R-DME-9629569); (R-DME-975956); (R-DME-975957); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 14, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;23636399;24550463;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9V6Z0", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005791 rough endoplasmic reticulum;GO:0005829 cytosol;GO:0005840 ribosome;GO:0022626 cytosolic ribosome;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0006412 translation;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8T3U2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q95TU8-1", "uniprot_id": [ { "id": "UNC5_DROME", "url": "https://www.uniprot.org/uniprot/Q95TU8", "type": "external" } ], "mass": 116418.0, "length": 1072, "protein_name": "Netrin receptor unc-5", "gene_name": "unc-5", "organism": "Fruit fly", "refseq_name": "unc-5, isoform B", "refseq_ac": [ { "id": "NP_001286450", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286450", "type": "external" } ], "gene_names_uniprotkb": "unc-5; AAF7419; CG8166; CG8168; CT20824; Dmel\\CG8166; Dmel_CG8166; Dunc5; UNC-5; UNC5D; UNC5; Unc-5; Unc5d; Unc5; dUnc5; unc5", "gene_names_refseq": "AAF7419; CG8166; CG8168; CT20824; Dmel\\CG8166; Dunc5; UNC-5; UNC5D; UNC5; Unc-5; Unc5d; Unc5; dUnc5; unc-5; unc5", "protein_names_uniprotkb": "Netrin receptor unc-5; Unc5 netrin receptor", "protein_names_refseq": "CG8166-PB; UNC5 protein; Unc-5; Uncoordinated5; unc-5, isoform B; unc-5-PB; unc-5-like; uncoordinated 5", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8166); (R-DME-373752)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;11719202;12537568;12537569;12537572;12537573;12537574;12765609;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding., [UniProtKB, UniProtKB]; Receptor for netrin required for motor axon guidance. Mediates both short- and long-range axon motor repulsion in the developing nervous system upon ligand binding. Also involved in glial migration. While short-range repulsion requires both fra and unc-5, long-range repulsion only requires unc-5., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9NBL0;Q9V7B5", "ec_number_list": [], "go_molecular_function": "GO:0005043 netrin receptor activity involved in chemorepulsion;GO:0005042 netrin receptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0007411 axon guidance;GO:0008045 motor neuron axon guidance;GO:0008347 glial cell migration;GO:0007432 salivary gland boundary specification", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q95TU8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V7S5-1", "uniprot_id": [ { "id": "PICO_DROME", "url": "https://www.uniprot.org/uniprot/Q9V7S5", "type": "external" } ], "mass": 58372.0, "length": 529, "protein_name": "Putative inorganic phosphate cotransporter", "gene_name": "Picot", "organism": "Fruit fly", "refseq_name": "picot, isoform C", "refseq_ac": [ { "id": "NP_001286496", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286496", "type": "external" } ], "gene_names_uniprotkb": "Picot; CG8098; Dmel\\CG8098; Dmel_CG8098; MFS8; picot", "gene_names_refseq": "CG8098; Dmel\\CG8098; MFS8; Picot; picot", "protein_names_uniprotkb": "Putative inorganic phosphate cotransporter", "protein_names_refseq": "CG8098-PC; Picot-PC; picot, isoform C; putative inorganic phosphate cotransporter", "tax_id": 7227, "disease": "lysosomal storage disease (Disease Ontology:DOID:3211); sialuria (Disease Ontology:DOID:3659)", "pathway": " (dme:Dmel_CG8098); (R-DME-2672351); (R-DME-427652)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "May be an inorganic phosphate cotransporter., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O61364;Q8T077;Q9V7S6", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015293 symporter activity;GO:0005315 phosphate transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006814 sodium ion transport;GO:0035435 phosphate ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9V7S5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V818-1", "uniprot_id": [ { "id": "MTH3_DROME", "url": "https://www.uniprot.org/uniprot/Q9V818", "type": "external" } ], "mass": 58757.0, "length": 511, "protein_name": "Probable G protein-coupled receptor Mth-like 3", "gene_name": "mthl3", "organism": "Fruit fly", "refseq_name": "methuselah-like 3, isoform B", "refseq_ac": [ { "id": "NP_001286526", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286526", "type": "external" } ], "gene_names_uniprotkb": "mthl3; 8; BEST:GM02553; CG6530; Dmel\\CG6530; Dmel_CG6530; GENE 1; Mth-3; Mthl3; anon-WO0170980.52; anon-WO0170980.53; gene 1; l(2)k10408; mthl-3", "gene_names_refseq": "104/8; BEST:GM02553; CG6530; Dmel\\CG6530; GENE 1; Mth-3; Mthl3; anon-WO0170980.52; anon-WO0170980.53; gene 1; l(2)k10408; mthl-3; mthl3", "protein_names_uniprotkb": "Probable G protein-coupled receptor Mth-like 3; Protein methuselah-like 3", "protein_names_refseq": "CG6530-PB; Methuselah-like 3; Mth-like 3; methuselah-like 3, isoform B; mthl3-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6530)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;10908591;12537568;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008528 G protein-coupled peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0042594 response to starvation;GO:0008340 determination of adult lifespan", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9V818-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KN62-1", "uniprot_id": [ { "id": "TERA_DROME", "url": "https://www.uniprot.org/uniprot/Q7KN62", "type": "external" } ], "mass": 88859.0, "length": 801, "protein_name": "Transitional endoplasmic reticulum ATPase TER94", "gene_name": "TER94", "organism": "Fruit fly", "refseq_name": "transitional endoplasmic reticulum 94, isoform C", "refseq_ac": [ { "id": "NP_001097249", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097249", "type": "external" } ], "gene_names_uniprotkb": "TER94; 22.26; 7.12; Apple; BcDNA.GM02885; BcDNA:GM02885; CDC48; CG2331; DmTER94; Dmel\\CG2331; Dmel_CG2331; I; Q7KN62; Ter 94; Ter94; Tera; VCP ATPase; VCP1; VCP; VIII; Vcp; anon-WO2004063362.65; anon-WO2004063362.67; cdc48; dTERA; dVCP; dmTERA; dvcp; l(2)03775; l(2)46CFf; l(2)46CFs; l(2)46Ch; l(2)46Db; p97; pTER94; ter94; vcp", "gene_names_refseq": "(VCP)/p97; 22.26; 7.12; Apple; BcDNA.GM02885; BcDNA:GM02885; CDC48; CG2331; DmTER94; Dmel\\CG2331; I; Q7KN62; TER94; Ter 94; Ter94; Tera; VCP ATPase; VCP/p97; VCP1; VCP; VIII; Vcp; anon-WO2004063362.65; anon-WO2004063362.67; cdc48; dTERA; dVCP; dmTERA; dvcp; l(2)03775; l(2)46CFf; l(2)46CFs; l(2)46Ch; l(2)46Db; p97; pTER94; ter94; vcp", "protein_names_uniprotkb": "Transitional endoplasmic reticulum ATPase TER94; 3.6.4.6; Valosin-containing protein homolog", "protein_names_refseq": "CG2331-PC; TER94-PC; TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE TER94; Ter94; VCP; Valosin-Containing protein; complementation group I; group VIII; lethal (2) 46Db; p97 ATPase; p97; transitional endoplasmic reticulum 94, isoform C; transitional endoplasmic reticulum 94; transitional endoplasmic reticulum ATPase; valosin containing protein", "tax_id": 7227, "disease": "inclusion body myopathy with Paget disease of bone and frontotemporal dementia (Disease Ontology:DOID:0050881); frontotemporal dementia and/or amyotrophic lateral sclerosis 6 (Disease Ontology:DOID:0060205); Charcot-Marie-Tooth disease type 2Y (Disease Ontology:DOID:0110168); inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1 (Disease Ontology:DOID:0111385); neurodegenerative disease (Disease Ontology:DOID:1289); dementia (Disease Ontology:DOID:1307); inclusion body myositis (Disease Ontology:DOID:3429); Paget's disease of bone (Disease Ontology:DOID:5408); primary ovarian insufficiency (Disease Ontology:DOID:5426); frontotemporal dementia (Disease Ontology:DOID:9255)", "pathway": " (dme:Dmel_CG2331); (R-DME-110320); (R-DME-3371511); (R-DME-382556); (R-DME-532668); (R-DME-5358346); (R-DME-5689896); (R-DME-6798695); (R-DME-8951664); (R-DME-9013407); (R-DME-9755511)", "pathway_count": 11, "publication_count": 21, "publication_id_list": "10564274;10656772;10731132;10731138;12537568;12537572;12537573;12537574;14657277;15952742;16110336;17372656;17569856;17569867;18590813;21447556;25589440;26109356;26109357;26471729;9639875", "class_list": "", "function": "Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Involved in the ubiquitin-proteasome system. Important for oskar mRNA localization and/or anchoring during oogenesis. Involved in germ cell formation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8DY85;A8DY86;O76279;Q9U463", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "5.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.-", "type": "external" }, { "id": "3.5.2.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.17", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.5.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.52", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "5.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.5", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.-.-.-", "type": "external" }, { "id": "5.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.1", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "1.11.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0016887 ATP hydrolysis activity;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0006508 proteolysis;GO:0046716 muscle cell cellular homeostasis;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q7KN62-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8MKJ4-1", "uniprot_id": [ { "id": "OB57B_DROME", "url": "https://www.uniprot.org/uniprot/Q8MKJ4", "type": "external" } ], "mass": 16663.0, "length": 141, "protein_name": "General odorant-binding protein 57b", "gene_name": "Obp57b", "organism": "Fruit fly", "refseq_name": "Odorant-binding protein 57b, isoform B", "refseq_ac": [ { "id": "NP_001286632", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286632", "type": "external" } ], "gene_names_uniprotkb": "Obp57b; 57b; CG30142; DmelObp57b; Dmel\\CG30142; Dmel_CG30142; OBP57b; Obp-e; anon-AE003792.2; obp57b", "gene_names_refseq": "57b; CG30142; DmelObp57b; Dmel\\CG30142; OBP57b; Obp-e; Obp57b; anon-AE003792.2; obp57b", "protein_names_uniprotkb": "General odorant-binding protein 57b", "protein_names_refseq": "CG30142-PB; Obp57b-PB; Odorant-binding protein 57b, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG30142)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12119098;12213773;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005549 odorant binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007608 sensory perception of smell;GO:0007606 sensory perception of chemical stimulus;GO:1990834 response to odorant", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8MKJ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24141-1", "uniprot_id": [ { "id": "SGO1_DROME", "url": "https://www.uniprot.org/uniprot/Q24141", "type": "external" } ], "mass": 44402.0, "length": 401, "protein_name": "Shugoshin", "gene_name": "mei-S332", "organism": "Fruit fly", "refseq_name": "meiotic from via salaria 332, isoform B", "refseq_ac": [ { "id": "NP_001286705", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286705", "type": "external" } ], "gene_names_uniprotkb": "mei-S332; BEST:LD13774; CG5303; Dmel\\CG5303; Dmel_CG5303; MEI-S322; MEI-S332; Mei-S332; MeiS332; Shugoshin; mei-S322; mei-s332; meiS322; meiS332", "gene_names_refseq": "BEST:LD13774; CG5303; Dmel\\CG5303; MEI-S322; MEI-S332; Mei-S332/Shugoshin; Mei-S332; MeiS332; mei-S322; mei-S332; mei-s332; meiS322; meiS332", "protein_names_uniprotkb": "Shugoshin; Meiotic protein S332", "protein_names_refseq": "CG5303-PB; Mei-S332; MeiS332; mei-S332-PB; meiotic from salaria 332; meiotic from via salaria 332, isoform B; shugoshin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5303)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10654079;10731132;10985388;12537568;12537569;12537572;12537573;12537574;15268859;15621529;16110336;16824953;17569856;17569867;25589440;26109356;26109357;7585942;9490715;9869638", "class_list": "", "function": "Plays a central role in chromosome cohesion during meiosis and mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by protecting or Rad21 from cleavage by Sse/separase. Required during meiosis in both males and females., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0000775 chromosome, centromeric region;GO:0005694 chromosome;GO:0000779 condensed chromosome, centromeric region;GO:0005721 pericentric heterochromatin", "go_biological_process": "GO:0051301 cell division;GO:0007143 female meiotic nuclear division;GO:0007140 male meiotic nuclear division;GO:0045132 meiotic chromosome segregation;GO:0007062 sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q24141-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82701-1", "uniprot_id": [ { "id": "IM18_DROME", "url": "https://www.uniprot.org/uniprot/P82701", "type": "external" } ], "mass": 7205.0, "length": 71, "protein_name": "Immune-induced peptide 18", "gene_name": "IM18; Pai", "organism": "Fruit fly", "refseq_name": "immune induced molecule 18, isoform A", "refseq_ac": [ { "id": "NP_001027447", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027447", "type": "external" } ], "gene_names_uniprotkb": "IM18; Pai; BcDNA:AT19986; CG33706; DIM 18; Dmel\\CG33706; Dmel_CG33706; IM18; anon-WO0153538.56; anon-WO0153538.57; anon-WO0153538.58", "gene_names_refseq": "BcDNA:AT19986; CG33706; DIM 18; Dmel\\CG33706; IM18; anon-WO0153538.56; anon-WO0153538.57; anon-WO0153538.58", "protein_names_uniprotkb": "Immune-induced peptide 18; DIM-18", "protein_names_refseq": "CG33706-PA; IM18-PA; immune induced molecule 18, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33706)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;9736738", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C4IXR8;Q59E66", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0098542 defense response to other organism;GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P82701-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V3H8-1", "uniprot_id": [ { "id": "NXT1_DROME", "url": "https://www.uniprot.org/uniprot/Q9V3H8", "type": "external" } ], "mass": 15181.0, "length": 133, "protein_name": "NTF2-related export protein", "gene_name": "Nxt1", "organism": "Fruit fly", "refseq_name": "NTF2-related export protein 1, isoform A", "refseq_ac": [ { "id": "NP_611833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611833", "type": "external" } ], "gene_names_uniprotkb": "Nxt1; CG12752; DmNXT1; Dmel\\CG12752; Dmel_CG12752; NXT1; Nxt-1; Nxt; dNxt1; dNxt; dmNXT1; dmNXT; dmP15; nxt1; p15", "gene_names_refseq": "CG12752; DmNXT1; Dmel\\CG12752; NXT1; Nxt-1; Nxt1; Nxt; dNxt1; dNxt; dmNXT1; dmNXT; dmP15; nxt1; p15", "protein_names_uniprotkb": "NTF2-related export protein; p15", "protein_names_refseq": "CG12752-PA; NTF2-related export protein 1, isoform A; Nxt1-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12752); (R-DME-159236)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10567585;10731132;12537568;12537569;12537572;12537573;12537574;14729961;16110336;17569856;17569867;25589440;26109356;26109357;31219034;31368590;31384064;31570835;33856346", "class_list": "", "function": "Stimulator of protein export for NES-containing proteins (By similarity). Plays a role in the nuclear export of mRNA (PubMed:14729961). Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (By similarity). In ovaries, plays a role in transposable element silencing regulation (PubMed:31219034, PubMed:31368590, PubMed:31384064, PubMed:31570835, PubMed:33856346). Forms a complex with nxf2, Panx and piwi which acts as effector of cotranscriptional transposon silencing (PubMed:31219034, PubMed:31368590, PubMed:31384064, PubMed:31570835). In ovarian follicle cells, enables the nuclear export of flamenco (flam) transcripts and subsequent piRNA biogenesis (PubMed:33856346)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0017053 transcription repressor complex", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0006406 mRNA export from nucleus;GO:0015031 protein transport;GO:0050829 defense response to Gram-negative bacterium;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9V3H8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24535-1", "uniprot_id": [ { "id": "SRF_DROME", "url": "https://www.uniprot.org/uniprot/Q24535", "type": "external" } ], "mass": 47621.0, "length": 449, "protein_name": "Serum response factor homolog", "gene_name": "bs", "organism": "Fruit fly", "refseq_name": "blistered, isoform C", "refseq_ac": [ { "id": "NP_001286837", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286837", "type": "external" } ], "gene_names_uniprotkb": "bs; BS; Bs; CG3411; D-SRF; DSRF; DSrf; DmSRF; Dmel\\CG3411; Dmel_CG3411; Drf; Dsrf; Group IIc; Mal; SRF; Serf; Srf; ba; bs; dSRF; dsrf; l(2)03267; px; srf", "gene_names_refseq": "BS; Bs; CG3411; D-SRF; DSRF; DSrf/bs; DSrf; DmSRF; Dmel\\CG3411; Drf; Group IIc; Mal; SRF; Serf; Srf; ba; bs/DSRF; bs/Dsrf; bs; dSRF; dsrf; l(2)03267; pruned/DSRF; px; srf", "protein_names_uniprotkb": "Serum response factor homolog; Protein blistered; dSRF", "protein_names_refseq": "CG3411-PC; SRF; balloon; blistered, isoform C; blistered/DSRF; blistered/Drosophila serum response factor; bs-PC; drosophila serum response factor; pruned", "tax_id": 7227, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); hypertension (Disease Ontology:DOID:10763); dilated cardiomyopathy (Disease Ontology:DOID:12930); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dme:Dmel_CG3411); (R-DME-5663220)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10731132;10940622;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;7600954;8787734", "class_list": "", "function": "Required for the formation of intervein tissue of the wing. Acts in a dosage-dependent manner to suppress wing vein formation and promote development of intervein cells. Might play a role in the proper formation and maintenance of the trachea., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W182", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0140297 DNA-binding transcription factor binding;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007614 short-term memory;GO:0030431 sleep", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q24535-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VGG8-1", "uniprot_id": [ { "id": "MTH5_DROME", "url": "https://www.uniprot.org/uniprot/Q9VGG8", "type": "external" } ], "mass": 56351.0, "length": 496, "protein_name": "Probable G protein-coupled receptor Mth-like 5", "gene_name": "mthl5", "organism": "Fruit fly", "refseq_name": "methuselah-like 5, isoform A", "refseq_ac": [ { "id": "NP_650126", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650126", "type": "external" } ], "gene_names_uniprotkb": "mthl5; CG6965; Dmel\\CG6965; Dmel_CG6965; Gia; Mth-5; Mthl5; anon-WO0170980.70; anon-WO0170980.71; mth15", "gene_names_refseq": "CG6965; Dmel\\CG6965; Gia; Mth-5; Mthl5; anon-WO0170980.70; anon-WO0170980.71; mth15; mthl5", "protein_names_uniprotkb": "Probable G protein-coupled receptor Mth-like 5; Protein methuselah-like 5", "protein_names_refseq": "CG6965-PA; GPCR in aorta; Methuselah-like 5; Mth-like 5; methuselah-like 5, isoform A; mthl5-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6965)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;10908591;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8MRB8", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0042594 response to starvation;GO:0003007 heart morphogenesis;GO:0008340 determination of adult lifespan", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VGG8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8I0P1-1", "uniprot_id": [ { "id": "SPAST_DROME", "url": "https://www.uniprot.org/uniprot/Q8I0P1", "type": "external" } ], "mass": 82749.0, "length": 758, "protein_name": "Spastin", "gene_name": "spas", "organism": "Fruit fly", "refseq_name": "spastin, isoform E", "refseq_ac": [ { "id": "NP_001303438", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303438", "type": "external" } ], "gene_names_uniprotkb": "spas; CG5977; D-spastin; Dmel\\CG5977; Dmel_CG5977; Dspastin; SPAST; SPAS; Spastin; Spas", "gene_names_refseq": "CG5977; D-spastin; Dmel\\CG5977; Dspastin; SPAST; SPAS; Spastin; Spas; spas", "protein_names_uniprotkb": "Spastin; 5.6.1.1; D-Spastin; Dm-Spastin; Dspastin", "protein_names_refseq": "CG5977-PE; D-spastin; Dm-Spastin; dspastin; spas-PE; spasin; spastin, isoform E", "tax_id": 7227, "disease": "hereditary spastic paraplegia 4 (Disease Ontology:DOID:0110792); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (dme:Dmel_CG5977); (R-DME-9668328)", "pathway_count": 2, "publication_count": 25, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;12908108;15242610;15562320;15823537;16110336;16276413;17452528;17569856;17569867;18202664;18327897;19341724;23122959;25589440;25875445;26109356;26109357;26744324;31285604", "class_list": "", "function": "ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 44, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IMX5;Q8T066", "ec_number_list": [ { "id": "5.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" } ], "go_molecular_function": "GO:0008568 microtubule severing ATPase activity;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005813 centrosome;GO:0005819 spindle;GO:0005874 microtubule", "go_biological_process": "GO:0007079 mitotic chromosome movement towards spindle pole;GO:0045834 positive regulation of lipid metabolic process;GO:0051013 microtubule severing;GO:0031117 positive regulation of microtubule depolymerization;GO:2000331 regulation of terminal button organization", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q8I0P1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51905-1", "uniprot_id": [ { "id": "SC6A4_DROME", "url": "https://www.uniprot.org/uniprot/P51905", "type": "external" } ], "mass": 69326.0, "length": 622, "protein_name": "Sodium-dependent serotonin transporter", "gene_name": "SerT", "organism": "Fruit fly", "refseq_name": "serotonin transporter, isoform B", "refseq_ac": [ { "id": "NP_001286839", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286839", "type": "external" } ], "gene_names_uniprotkb": "SerT; CG4545; DmSERT; DmSerT; Dmel\\CG4545; Dmel_CG4545; SERT; Sert; dSERT1; dSERT; dSerT; dSert; dmSERT; dsert; serT", "gene_names_refseq": "CG4545; DmSERT; DmSerT; Dmel\\CG4545; SERT; SerT; Sert; dSERT1; dSERT; dSerT; dSert; dmSERT; dsert; serT", "protein_names_uniprotkb": "Sodium-dependent serotonin transporter; 5HT transporter; 5HTT; Cocaine-sensitive serotonin transporter; dSERT1", "protein_names_refseq": "CG4545-PB; SerT-PB; cocaine-sensitive serotonin transporter; drosophila serotonin transporter; serotonin transporter, isoform B", "tax_id": 7227, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); obstructive sleep apnea (Disease Ontology:DOID:0050848); autism spectrum disorder (Disease Ontology:DOID:0060041); alexithymia (Disease Ontology:DOID:0060131); Parkinsonism (Disease Ontology:DOID:0080855); obsessive-compulsive disorder (Disease Ontology:DOID:10933); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); heart disease (Disease Ontology:DOID:114); dengue hemorrhagic fever (Disease Ontology:DOID:12206); autistic disorder (Disease Ontology:DOID:12849); generalized anxiety disorder (Disease Ontology:DOID:14320); major depressive disorder (Disease Ontology:DOID:1470); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); anxiety disorder (Disease Ontology:DOID:2030); asthma (Disease Ontology:DOID:2841); substance abuse (Disease Ontology:DOID:302); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); bipolar disorder (Disease Ontology:DOID:3312); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); liver cirrhosis (Disease Ontology:DOID:5082); borna disease (Disease Ontology:DOID:5154); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); diverticulitis (Disease Ontology:DOID:7475); cocaine abuse (Disease Ontology:DOID:809); chronic fatigue syndrome (Disease Ontology:DOID:8544); sudden infant death syndrome (Disease Ontology:DOID:9007); leishmaniasis (Disease Ontology:DOID:9065); brain disease (Disease Ontology:DOID:936)", "pathway": " (dme:Dmel_CG4545); (R-DME-380615); (R-DME-442660)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8197200;8302852", "class_list": "", "function": "Terminates the action of serotonin by its high affinity sodium-dependent reuptake into presynaptic terminals., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 31, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q23969;Q9W177", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051378 serotonin binding;GO:0008504 monoamine transmembrane transporter activity;GO:0005335 serotonin:sodium:chloride symporter activity;GO:0015293 symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0043679 axon terminus;GO:0045202 synapse;GO:0043005 neuron projection", "go_biological_process": "GO:0015844 monoamine transport;GO:0006865 amino acid transport;GO:0035725 sodium ion transmembrane transport;GO:0006837 serotonin transport;GO:0051610 serotonin uptake", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P51905-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27575-1", "uniprot_id": [ { "id": "PSA73_DROME", "url": "https://www.uniprot.org/uniprot/Q27575", "type": "external" } ], "mass": 28720.0, "length": 252, "protein_name": "Proteasome subunit alpha type-7-1B", "gene_name": "Prosalpha4T2", "organism": "Fruit fly", "refseq_name": "proteasome alpha4 subunit, Testis-specific 2, isoform B", "refseq_ac": [ { "id": "NP_001286844", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286844", "type": "external" } ], "gene_names_uniprotkb": "Prosalpha4T2; CG4569; Dmel\\CG4569; Dmel_CG4569; Pros28.1B; a4-t2; alpha4T2; alpha4t2_dm; alpha4t2; dalpha7; pros28.1B", "gene_names_refseq": "CG4569; Dmel\\CG4569; Pros28.1B; Prosalpha4T2; a4-t2; alpha4T2; alpha4t2_dm; alpha4t2; dalpha7; pros28.1B", "protein_names_uniprotkb": "Proteasome subunit alpha type-7-1B; Testis-specific alpha4-t2 proteasome subunit; Testis-specific proteasome 28 kDa subunit 1B", "protein_names_refseq": "20s proteasome; CG4569-PB; Pros28.1B; Prosalpha4T2-PB; proteasome 28kD subunit 1B; proteasome alpha 4 subunit, Testis-specific 2; proteasome alpha4 subunit, Testis-specific 2, isoform B; testes-specific proteasome subunit", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4569); (R-DME-1169091); (R-DME-1234176); (R-DME-1236974); (R-DME-1236978); (R-DME-174084); (R-DME-174154); (R-DME-174178); (R-DME-174184); (R-DME-187577); (R-DME-195253); (R-DME-202424); (R-DME-2467813); (R-DME-2871837); (R-DME-350562); (R-DME-382556); (R-DME-450408); (R-DME-4608870); (R-DME-4641257); (R-DME-4641258); (R-DME-5358346); (R-DME-5607761); (R-DME-5607764); (R-DME-5610780); (R-DME-5610785); (R-DME-5632684); (R-DME-5658442); (R-DME-5676590); (R-DME-5689603); (R-DME-5689880); (R-DME-68867); (R-DME-68949); (R-DME-69017); (R-DME-69601); (R-DME-75815); (R-DME-8854050); (R-DME-8939236); (R-DME-8939902); (R-DME-8941858); (R-DME-8948751); (R-DME-8951664); (R-DME-9020702); (R-DME-9755511); (R-DME-9762114); (R-DME-983168); (R-DME-9907900); (R-DME-9912633); (R-DME-9929491); (R-DME-9932298); (R-DME-9954709)", "pathway_count": 50, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15579695;16110336;17569856;17569867;25589440;26109356;26109357;8878681", "class_list": "", "function": "The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6QH11;Q8T3X2;Q9W162", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0019773 proteasome core complex, alpha-subunit complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q27575-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VHV8-1", "uniprot_id": [ { "id": "Q9VHV8_DROME", "url": "https://www.uniprot.org/uniprot/Q9VHV8", "type": "external" } ], "mass": 51271.0, "length": 476, "protein_name": "protein-tyrosine-phosphatase", "gene_name": "puc", "organism": "Fruit fly", "refseq_name": "puckered, isoform A", "refseq_ac": [ { "id": "NP_524273", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524273", "type": "external" } ], "gene_names_uniprotkb": "puc; 03; 08; CG7850; Dmel\\CG7850; Dmel_CG7850; JNK-DSP; MKP; PUC; Puc; dPuc; hrt; l(3)84Eh; l(3)A251.1; l(3)j4E1; vco", "gene_names_refseq": "0238/03; 1351/08; CG7850; Dmel\\CG7850; JNK-DSP; PUC/MKP; PUC; Puc; dPuc; hrt; l(3)84Eh; l(3)A251.1; l(3)j4E1; puc; vco", "protein_names_uniprotkb": "protein-tyrosine-phosphatase; 3.1.3.48", "protein_names_refseq": "CG7850-PA; Jun N-terminal kinase dual-specificity phosphatase; hearty; lethal (3) j4E1; puc-PA; puckered, isoform A; puckered; velcro", "tax_id": 7227, "disease": "carcinoma (Disease Ontology:DOID:305); pancreatitis (Disease Ontology:DOID:4989)", "pathway": " (dme:Dmel_CG7850); (R-DME-112409); (R-DME-5675221)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;19818708;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" } ], "go_molecular_function": "GO:0008579 JUN kinase phosphatase activity;GO:0004721 phosphoprotein phosphatase activity;GO:0004725 protein tyrosine phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0008330 protein tyrosine/threonine phosphatase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0048749 compound eye development;GO:0006979 response to oxidative stress;GO:0043066 negative regulation of apoptotic process;GO:0007254 JNK cascade;GO:0008544 epidermis development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VHV8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VCX4-1", "uniprot_id": [ { "id": "RRF2M_DROME", "url": "https://www.uniprot.org/uniprot/Q9VCX4", "type": "external" } ], "mass": 81961.0, "length": 740, "protein_name": "Ribosome-releasing factor 2, mitochondrial", "gene_name": "mRRF2", "organism": "Fruit fly", "refseq_name": "mitochondrial ribosome recycling factor 2, isoform A", "refseq_ac": [ { "id": "NP_732771", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_732771", "type": "external" } ], "gene_names_uniprotkb": "mRRF2; CG31159; CG6943; Dmel\\CG31159; Dmel_CG31159; EF-G2; dEF-G2", "gene_names_refseq": "CG31159; CG6943; Dmel\\CG31159; EF-G2; dEF-G2; mRRF2", "protein_names_uniprotkb": "Ribosome-releasing factor 2, mitochondrial; EF-G2mt; Elongation factor G 2, mitochondrial; Elongation factor G2; RRF2mt; Ribosome-recycling factor 2, mitochondrial; mEF-G 2", "protein_names_refseq": "CG31159-PA; elongation factor G2; mRRF2-PA; mitochondrial ribosome recycling factor 2, isoform A", "tax_id": 7227, "disease": "combined oxidative phosphorylation deficiency 39 (Disease Ontology:DOID:0111475)", "pathway": " (dme:Dmel_CG31159); (R-DME-5419276)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;20132446;21364917;25589440;26109356;26109357", "class_list": "", "function": "Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3KU70;F1JZV4", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0032790 ribosome disassembly;GO:0032543 mitochondrial translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VCX4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q45VV3-1", "uniprot_id": [ { "id": "YAP1_DROME", "url": "https://www.uniprot.org/uniprot/Q45VV3", "type": "external" } ], "mass": 43594.0, "length": 395, "protein_name": "Transcriptional coactivator yorkie", "gene_name": "yki", "organism": "Fruit fly", "refseq_name": "yorkie, isoform F", "refseq_ac": [ { "id": "NP_001036568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036568", "type": "external" } ], "gene_names_uniprotkb": "yki; CG4005; Dmel\\CG4005; Dmel_CG4005; Taz; YAP; YKI; Yap; Yki; Yorkie; yap", "gene_names_refseq": "CG4005; Dmel\\CG4005; YAP; YKI; Yap/Taz; Yap; Yki; Yorkie; yap; yki", "protein_names_uniprotkb": "Transcriptional coactivator yorkie; Protein yorkie; Transcriptional coactivator YAP1 homolog", "protein_names_refseq": "CG4005-PF; yki-PF; yorkie, isoform F; yorkie; yorki", "tax_id": 7227, "disease": "cone dystrophy (Disease Ontology:DOID:0050795); uveal coloboma-cleft lip and palate-intellectual disability (Disease Ontology:DOID:0111249); intestinal cancer (Disease Ontology:DOID:10155); heart disease (Disease Ontology:DOID:114); coloboma (Disease Ontology:DOID:12270); nephronophthisis (Disease Ontology:DOID:12712); neurodegenerative disease (Disease Ontology:DOID:1289); cancer (Disease Ontology:DOID:162); ovarian cancer (Disease Ontology:DOID:2394); carcinoma (Disease Ontology:DOID:305); nephrolithiasis (Disease Ontology:DOID:585); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dme:Dmel_CG4005); (R-DME-1251985); (R-DME-2028269); (R-DME-2032785); (R-DME-2173796); (R-DME-390098); (R-DME-390193); (R-DME-451806); (R-DME-8939236); (R-DME-8951671); (R-DME-9860927)", "pathway_count": 11, "publication_count": 29, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16096061;16110336;17372656;17569856;17569867;17889654;18256197;18258485;18258486;18313299;18327897;19289086;19330023;19733165;19762509;19900439;22615583;25589440;26109356;26109357;26954546;27462444;31857346", "class_list": "", "function": "Transcriptional coactivator which is the critical downstream regulatory target in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:16096061, PubMed:18313299, PubMed:22615583, PubMed:27462444). The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein (PubMed:16096061, PubMed:19900439). The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam (PubMed:16096061, PubMed:18313299). Regulates the expression of G1/S-specific CycE and diap1, thereby promoting cell proliferation and inhibiting apoptosis (PubMed:18313299). Required for transcriptional activity of sd in wing imaginal disks (PubMed:18313299). Induces expression of expression of vestigial (vg) in wing and haltere disks and the expression of transcription factor E2f (E2f) (PubMed:18313299)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RVH0;A2RVH4;Q0E8X1;Q7KVG6;Q95TU5;Q9W1B6", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019900 kinase binding;GO:0071889 14-3-3 protein binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005911 cell-cell junction", "go_biological_process": "GO:0001708 cell fate specification;GO:0060252 positive regulation of glial cell proliferation;GO:0006351 DNA-templated transcription;GO:0008283 cell population proliferation;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q45VV3-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VFS5-1", "uniprot_id": [ { "id": "PP4R3_DROME", "url": "https://www.uniprot.org/uniprot/Q9VFS5", "type": "external" } ], "mass": 109295.0, "length": 980, "protein_name": "Serine/threonine-protein phosphatase 4 regulatory subunit 3", "gene_name": "flfl", "organism": "Fruit fly", "refseq_name": "falafel, isoform D", "refseq_ac": [ { "id": "NP_650304", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650304", "type": "external" } ], "gene_names_uniprotkb": "flfl; CG9351; Dmel\\CG9351; Dmel_CG9351; Flfl; PP4R3; Ppp4R3; l(3)L4179", "gene_names_refseq": "CG9351; Dmel\\CG9351; Flfl; PP4R3; Ppp4R3; flfl; l(3)L4179", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 4 regulatory subunit 3; PP4R3; Protein falafel", "protein_names_refseq": "CG9351-PD; falafel, isoform D; falafel; flfl-PD", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9351)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16085932;16110336;17569856;17569867;18487071;19204120;25589440;26109356;26109357", "class_list": "", "function": "Regulatory subunit of serine/threonine-protein phosphatase 4. The probable PP4 complex Pp4-19C-PPP4R2r-flfl (PPP4C-PPP4R2-PPP4R3) is required to prevent caspase induced cell death (in vitro). May be involved in DNA damage repair. Key mediator specific for the localization of mira and associated cell fate determinants during both interphase and mitosis. Nuclear Flfl is required to exclude mira/pros from the nucleus when inefficiently bound to the cytoskeleton/cortex, whereas cytosolic or membrane-associated flfl is required for the cortical association and asymmetric localization of mira/pros/brat/stau at metaphase and anaphase., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8MSX6", "ec_number_list": [], "go_molecular_function": "GO:0072542 protein phosphatase activator activity;GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0055059 asymmetric neuroblast division;GO:2000779 regulation of double-strand break repair;GO:0045175 basal protein localization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9VFS5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9GNK5-1", "uniprot_id": [ { "id": "PGPLC_DROME", "url": "https://www.uniprot.org/uniprot/Q9GNK5", "type": "external" } ], "mass": 56046.0, "length": 520, "protein_name": "Peptidoglycan-recognition protein LC", "gene_name": "PGRP-LC", "organism": "Fruit fly", "refseq_name": "peptidoglycan recognition protein LC, isoform D", "refseq_ac": [ { "id": "NP_001163396", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163396", "type": "external" } ], "gene_names_uniprotkb": "PGRP-LC; (PGRP)-LC; CG4432; Dm PGRP-LC; Dmel\\CG4432; Dmel_CG4432; PGRP-LCa; PGRP-LCd; PGRP-LCx; PGRPLC; Pgrp-LC; ird7; pgrp lc; pgrp-lc; pgrp; tot", "gene_names_refseq": "(PGRP)-LC; CG4432; Dm PGRP-LC; Dmel\\CG4432; PGRP-LCa; PGRP-LCd; PGRP-LCx; PGRP-LC; PGRPLC; Pgrp-LC; ird7; pgrp lc; pgrp-lc; pgrp; tot", "protein_names_uniprotkb": "Peptidoglycan-recognition protein LC; Immune response deficient 7 protein", "protein_names_refseq": "CG4432-PD; PG recognition receptor-LC; PGRP-LC-PD; Peptidoglycan-recognition protein-LC; immune response deficient 7; peptidoglycan recognition protein LC, isoform D; peptidoglycan recognition protein LC; peptidoglycan recognition protein-LC; totem", "tax_id": 7227, "disease": "lower respiratory tract disease (Disease Ontology:DOID:0050161)", "pathway": " (dme:Dmel_CG4432)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10731132;11106397;11872802;12537568;12537569;12537572;12537573;12537574;12777387;16006509;16110336;16556841;17569856;17569867;22022271;22496930;25589440;26109356;26109357;31350199", "class_list": "", "function": "Major activator of the imd/Relish pathway and is likely to encode a pattern recognition molecule for the humoral immune response (PubMed:11872802, PubMed:22022271). Required for Relish processing and nuclear translocation following proteolytic cleavage (PubMed:11872802). Involved in the response to lipopolysaccharide (LPS) and peptidoglycan of Gram-negative bacteria (PubMed:11872802). The different isoforms probably display different recognition capabilities to various microbial patterns (PubMed:12777387, PubMed:16006509)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Mediates the response to LPS and Gram-negative bacteria., [UniProtKB, PubMed, PubMed]; Mediates the response to LPS, peptidoglycan and Gram-negative bacteria., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q1EBX6;Q7YW58;Q8T5Q2;Q9VSV9", "ec_number_list": [], "go_molecular_function": "GO:0042834 peptidoglycan binding;GO:0008270 zinc ion binding;GO:0016019 peptidoglycan immune receptor activity;GO:0001875 lipopolysaccharide immune receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031410 cytoplasmic vesicle;GO:0098793 presynapse", "go_biological_process": "GO:0006955 immune response;GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9GNK5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4LBB9-1", "uniprot_id": [ { "id": "OCTB2_DROME", "url": "https://www.uniprot.org/uniprot/Q4LBB9", "type": "external" } ], "mass": 60379.0, "length": 536, "protein_name": "Octopamine receptor beta-2R", "gene_name": "Octbeta2R", "organism": "Fruit fly", "refseq_name": "octopamine beta2 receptor, isoform A", "refseq_ac": [ { "id": "NP_001034049", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034049", "type": "external" } ], "gene_names_uniprotkb": "Octbeta2R; CG18553; CG33976; CG6989; DmCG6989; DmOctbeta2R; Dm_3R:45121; Dmel\\CG33976; Dmel_CG33976; OCTbeta2R; OctB2R; OctBeta2; Octb2R; Octbeta-like; Octbeta2r; Octbeta2; anon-WO0170980.184; anon-WO0170980.185; octb2R; octbeta2R; octbeta2r", "gene_names_refseq": "CG18553; CG33976; CG6989; DmCG6989; DmOctbeta2R; Dm_3R:45121; Dmel\\CG33976; OCTbeta2R; OctB2R; OctBeta2; Octb2R; Octbeta-like; Octbeta2R; Octbeta2r; anon-WO0170980.184; anon-WO0170980.185; octb2R; octbeta2R; octbeta2r", "protein_names_uniprotkb": "Octopamine receptor beta-2R; DmOct-beta-12; DmOct-beta-2R", "protein_names_refseq": "CG33976-PA; OctBeta2R; Octbeta2R-PA; octopamine beta receptor; octopamine beta2 receptor, isoform A; octopamine receptor", "tax_id": 7227, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); obstructive sleep apnea (Disease Ontology:DOID:0050848); colitis (Disease Ontology:DOID:0060180); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); childhood-onset asthma (Disease Ontology:DOID:0080815); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); Alzheimer's disease (Disease Ontology:DOID:10652); open-angle glaucoma (Disease Ontology:DOID:1067); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); pulmonary edema (Disease Ontology:DOID:11396); polycystic ovary syndrome (Disease Ontology:DOID:11612); nephrosclerosis (Disease Ontology:DOID:11664); Graves' disease (Disease Ontology:DOID:12361); dilated cardiomyopathy (Disease Ontology:DOID:12930); gout (Disease Ontology:DOID:13189); low tension glaucoma (Disease Ontology:DOID:13544); endometrial cancer (Disease Ontology:DOID:1380); familial hypercholesterolemia (Disease Ontology:DOID:13810); interstitial cystitis (Disease Ontology:DOID:13949); toxic shock syndrome (Disease Ontology:DOID:14115); hypothyroidism (Disease Ontology:DOID:1459); cystic fibrosis (Disease Ontology:DOID:1485); urticaria (Disease Ontology:DOID:1555); renovascular hypertension (Disease Ontology:DOID:1591); aortic valve stenosis (Disease Ontology:DOID:1712); dermatitis (Disease Ontology:DOID:2723); asthma (Disease Ontology:DOID:2841); bronchiolitis (Disease Ontology:DOID:2942); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); hyperglycemia (Disease Ontology:DOID:4195); myasthenia gravis (Disease Ontology:DOID:437); cholangiocarcinoma (Disease Ontology:DOID:4947); pneumonia (Disease Ontology:DOID:552); kidney disease (Disease Ontology:DOID:557); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); myocarditis (Disease Ontology:DOID:820); periodontitis (Disease Ontology:DOID:824); ulcerative colitis (Disease Ontology:DOID:8577); anorexia nervosa (Disease Ontology:DOID:8689); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG33976); (R-DME-390651); (R-DME-390696); (R-DME-418555); (R-DME-5689880); (R-DME-8856825); (R-DME-8856828)", "pathway_count": 7, "publication_count": 17, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;15998303;16110336;17569856;17569867;21186359;22303848;22553037;25099506;25353988;25589440;26109356;26109357", "class_list": "", "function": "Autoreceptor for octopamine (OA), which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates (PubMed:15998303, PubMed:21186359). Essential for ovulation and fertilization (PubMed:25099506, PubMed:25353988). During ovulation it mediates the OA-induced relaxation of the oviduct visceral muscles, by increasing cAMP levels and activating effectors such as calmodulin-dependent kinase II (CaMKII) and cAMP-dependent protein kinase A (PKA) pathways (PubMed:25353988). Positively regulates synaptic growth; an action that is antagonized by Octbeta1R (PubMed:21186359, PubMed:22553037)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 51, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B7FNM5;Q9VG53;Q9VG54", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008227 G protein-coupled amine receptor activity;GO:0004989 octopamine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0009566 fertilization;GO:0043410 positive regulation of MAPK cascade;GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q4LBB9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P91938-1", "uniprot_id": [ { "id": "TRXR1_DROME", "url": "https://www.uniprot.org/uniprot/P91938", "type": "external" } ], "mass": 64322.0, "length": 596, "protein_name": "Thioredoxin reductase 1, mitochondrial", "gene_name": "Trxr1", "organism": "Fruit fly", "refseq_name": "thioredoxin reductase 1, isoform A", "refseq_ac": [ { "id": "NP_511082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_511082", "type": "external" } ], "gene_names_uniprotkb": "Trxr1; 2151; CG2151; DTR; Dm-TrxR; DmTR; DmTrxR-1; DmTrxR; DmTrx; Dmel\\CG2151; Dmel_CG2151; GR; Gr; TH; TRR; TRXR1; TrxR-1; TrxR1; TrxR; Trxr-1; Trxr; Trx; anon-WO03040301.185; anon-WO03040301.187; dTXNRD2; dTXNRD; dTrxR; dmtrxr-1; gr; l(1)G0154; l(1)G0379; l(1)G0477; l(1)G0481; trxr-1; trxr1", "gene_names_refseq": "2151; CG2151; DTR; Dm-TrxR; DmTR; DmTrxR-1; DmTrxR; DmTrx; Dmel\\CG2151; GR; Gr; TH; TRR; TRXR1; TrxR-1; TrxR1; TrxR; Trxr-1; Trxr1; Trxr; Trx; anon-WO03040301.185; anon-WO03040301.187; dTXNRD2; dTXNRD; dTrxR; dmtrxr-1; gr; l(1)G0154; l(1)G0379; l(1)G0477; l(1)G0481; trxr-1; trxr1", "protein_names_uniprotkb": "Thioredoxin reductase 1, mitochondrial; 1.8.1.9", "protein_names_refseq": "CG2151-PA; Trxr1-PA; disulfide reductase; glutathione reductase; thioredoxin reductase 1, isoform A; thioredoxin reductase-1; thioredoxin reductase", "tax_id": 7227, "disease": "chromosome 22q11.2 deletion syndrome, distal (Disease Ontology:DOID:0060413); familial glucocorticoid deficiency (Disease Ontology:DOID:0080620); limb-girdle muscular dystrophy (Disease Ontology:DOID:11724); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (dme:Dmel_CG2151); (R-DME-3299685); (R-DME-499943); (R-DME-5263617); (R-DME-5628897)", "pathway_count": 5, "publication_count": 21, "publication_id_list": "10731132;11158675;11525742;11782468;11796729;11877442;12537568;12537569;12537572;12537573;12537574;16110336;17385893;17569856;17569867;18211101;18991392;25589440;26109356;26109357;9056265", "class_list": "", "function": "Thioredoxin system is a major player in glutathione metabolism, due to the demonstrated absence of a glutathione reductase. Functionally interacts with the Sod/Cat reactive oxidation species (ROS) defense system and thereby has a role in preadult development and life span. Lack of a glutathione reductase suggests antioxidant defense in Drosophila, and probably in related insects, differs fundamentally from that in other organisms., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q1RKZ0;Q53YG2;Q961E3;Q9W3H2;Q9W3H3", "ec_number_list": [ { "id": "1.8.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.9", "type": "external" } ], "go_molecular_function": "GO:0004791 thioredoxin-disulfide reductase (NADPH) activity;GO:0042803 protein homodimerization activity;GO:0050660 flavin adenine dinucleotide binding;GO:0016209 antioxidant activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0045454 cell redox homeostasis;GO:0008340 determination of adult lifespan", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P91938-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IDD9-1", "uniprot_id": [ { "id": "SARM1_DROME", "url": "https://www.uniprot.org/uniprot/Q6IDD9", "type": "external" } ], "mass": 147884.0, "length": 1360, "protein_name": "NAD(+) hydrolase sarm1", "gene_name": "Sarm", "organism": "Fruit fly", "refseq_name": "sterile alpha and armadillo motif, isoform F", "refseq_ac": [ { "id": "NP_001036594", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036594", "type": "external" } ], "gene_names_uniprotkb": "Sarm; CG13680; CG13681; CG34373; CG43119; CG7905; CG7915; Dmel\\CG43119; Dmel_CG43119; ECT4; Ect4; Edis; SARM1; SARM; anon-WO0118547.272; circRNA Edis; circ_1705; circ_Ect4; dSARM1; dSARM; dSarm1; dSarm; dsarm; ect4; sarm", "gene_names_refseq": "CG13680; CG13681; CG34373; CG43119; CG7905; CG7915; Dmel\\CG43119; ECT4; Ect4/SARM; Ect4; Edis; SARM1; SARM; Sarm; anon-WO0118547.272; circRNA Edis; circ_1705; circ_Ect4; dSARM1; dSARM; dSarm1; dSarm; dsarm; ect4; sarm", "protein_names_uniprotkb": "NAD(+) hydrolase sarm1; 3.2.2.6; NADase sarm1; Sterile alpha and TIR motif-containing protein 1; Tir-1 homolog", "protein_names_refseq": "CG43119-PF; Ect4-derived immune suppressor; Ectoderm-expressed 4; SARM1; Sarm-PF; drosophila sterile alpha and armadillo motif; sterile alpha and armadillo motif, isoform F; sterile alpha, ARM, and TIR domain protein", "tax_id": 7227, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (dme:Dmel_CG43119)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;22022271;22678360;22837513;25589440;26109356;26109357;28334607;31439792", "class_list": "", "function": "NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (PubMed:22678360, PubMed:28334607). Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (PubMed:22678360). Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, it is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting axon destruction (PubMed:22678360, PubMed:28334607, PubMed:31439792). Involved in the down-regulation of the tracheal immune response to Gram-negative bacteria (PubMed:22022271). This is likely by mediating Tollo signaling in the tracheal epithelium (PubMed:22022271)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0E8H1;Q7KUA2;Q8SY48;Q9VSD2", "ec_number_list": [ { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" } ], "go_molecular_function": "GO:0097677 STAT family protein binding;GO:0035591 signaling adaptor activity;GO:0003953 NAD+ nucleosidase activity;GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0019677 NAD+ catabolic process;GO:0007165 signal transduction;GO:0051607 defense response to virus;GO:0048678 response to axon injury;GO:1904894 positive regulation of receptor signaling pathway via STAT", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q6IDD9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V9J3-1", "uniprot_id": [ { "id": "SRC42_DROME", "url": "https://www.uniprot.org/uniprot/Q9V9J3", "type": "external" } ], "mass": 59069.0, "length": 517, "protein_name": "Tyrosine-protein kinase Src42A", "gene_name": "Src42A", "organism": "Fruit fly", "refseq_name": "Src oncogene at 42A, isoform A", "refseq_ac": [ { "id": "NP_476849", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476849", "type": "external" } ], "gene_names_uniprotkb": "Src42A; CG14471; CG44128; CG7873; DSrc42A; Dm SRC41; DmHD-29; Dmel\\CG44128; Dmel_CG44128; Dsrc41; Dsrc42A; Dtk5; HD-29; SK2-4; SRC 42A; SRC42A; SRC; Src41; Src42a; Src42; Src; Su(D-raf)1; Su(Raf)1; Su(phl)1; Su1; TK5; Tk5; dSrc42A; dSrc; dtk-5; dtk5; l(2)k10108; pSrc; src42A; src42a; src42; src", "gene_names_refseq": "CG14471; CG44128; CG7873; DSrc42A; Dm SRC41; DmHD-29; Dmel\\CG44128; Dsrc41; Dsrc42A; Dtk5; HD-29; SK2-4; SRC 42A; SRC42A; SRC; Src41; Src42A; Src42a; Src42; Src; Su(D-raf)1; Su(Raf)1; Su(phl)1; Su1; Tk5; dSrc42A; dSrc; dtk-5; dtk5; l(2)k10108; pSrc; src42A; src42a; src42; src", "protein_names_uniprotkb": "Tyrosine-protein kinase Src42A; 2.7.10.2; Dsrc41; Tyrosine-protein kinase Src41", "protein_names_refseq": "CG44128-PA; Src oncogene at 42A, isoform A; Src42A-PA; src oncogene at 42A; suppressor of pole hole; suppressor of raf-like-oncogene; tyrosine kinase 5", "tax_id": 7227, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); stroke (Disease Ontology:DOID:0051061); ductal carcinoma in situ (Disease Ontology:DOID:0060074); colorectal carcinoma (Disease Ontology:DOID:0080199); Parkinsonism (Disease Ontology:DOID:0080855); maturity-onset diabetes of the young type 11 (Disease Ontology:DOID:0111109); immunodeficiency 22 (Disease Ontology:DOID:0111937); intestinal cancer (Disease Ontology:DOID:10155); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); allergic conjunctivitis (Disease Ontology:DOID:11204); lesion of sciatic nerve (Disease Ontology:DOID:12528); colon carcinoma (Disease Ontology:DOID:1520); thrombocytopenia (Disease Ontology:DOID:1588); status epilepticus (Disease Ontology:DOID:1824); Williams-Beuren syndrome (Disease Ontology:DOID:1928); colon cancer (Disease Ontology:DOID:219); brain ischemia (Disease Ontology:DOID:2316); colon adenocarcinoma (Disease Ontology:DOID:234); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); Goldenhar syndrome (Disease Ontology:DOID:2907); skin squamous cell carcinoma (Disease Ontology:DOID:3151); temporal lobe epilepsy (Disease Ontology:DOID:3328); skin disease (Disease Ontology:DOID:37); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung adenocarcinoma (Disease Ontology:DOID:3910); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); schizophrenia (Disease Ontology:DOID:5419); pancreatic acinar cell adenocarcinoma (Disease Ontology:DOID:5742); hepatocellular carcinoma (Disease Ontology:DOID:684); retinal degeneration (Disease Ontology:DOID:8466); systemic lupus erythematosus (Disease Ontology:DOID:9074); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dme:Dmel_CG44128); (R-DME-432553); (R-DME-6798695); (R-DME-8948751)", "pathway_count": 4, "publication_count": 38, "publication_id_list": "10731132;11430804;11440719;12014990;12122057;12432393;12442174;12447397;12537568;12537569;12537572;12537573;12537574;12563262;12944510;14759367;16110336;16319317;16410523;16831834;17418796;17569856;17569867;18432193;18593878;18815259;1915852;25589440;26028435;26109356;26109357;7481773;8596938;8600384;8682295;8938123;9674431;9731193", "class_list": "", "function": "Required directly or indirectly for the phosphorylation of drpr which is necessary for the interaction of drpr with shark and subsequent glial phagocytic activity (PubMed:18432193). Together with drpr and shark, promotes the migration of macrophages to sites of wounding as part of a signaling cascade where Src42A detects production of hydrogen peroxide at wound sites which triggers phosphorylation of drpr and subsequent recruitment and activation of shark (PubMed:26028435). Essential for correct eye morphogenesis (ommatidial R7 neuron formation) which requires the Ras1/MAPK signal transduction pathway (PubMed:8682295). May be involved in the regulation of cytoskeleton organization and cell-cell contacts in developing ommatidia (PubMed:8682295). Involved in phosphorylation of Dscam1, a cell surface receptor involved in targeting of growing axons during eye morphogenesis, and its interaction partner the SH2/SH3 adapter protein dock/dreadlocks (PubMed:12014990). During embryogenesis, involved in regulation of dorsal closure where it may have a role in activating the JNK pathway in leading edge cells during this process (PubMed:16831834)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 38, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O18369;Q0E9P0;Q26297;Q94879", "ec_number_list": [ { "id": "3.5.2.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.17", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.5.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.28", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.2.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.14", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "3.4.17.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.13", "type": "external" }, { "id": "1.11.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.-", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" } ], "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0048749 compound eye development;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0016477 cell migration;GO:0030154 cell differentiation;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "Q9V9J3-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7JR71-1", "uniprot_id": [ { "id": "SODE_DROME", "url": "https://www.uniprot.org/uniprot/Q7JR71", "type": "external" } ], "mass": 19221.0, "length": 181, "protein_name": "Extracellular superoxide dismutase [Cu-Zn]", "gene_name": "Sod3", "organism": "Fruit fly", "refseq_name": "superoxide dismutase 3, isoform D", "refseq_ac": [ { "id": "NP_001036536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036536", "type": "external" } ], "gene_names_uniprotkb": "Sod3; CG13200; CG9027; CT25938; Dmel\\CG9027; Dmel_CG9027; SOD3; dSOD3; dSod3; sod-3", "gene_names_refseq": "CG13200; CG9027; CT25938; Dmel/CG9027; Dmel\\CG9027; SOD3; Sod3; dSOD3; dSod3; sod-3", "protein_names_uniprotkb": "Extracellular superoxide dismutase [Cu-Zn]; 1.15.1.1", "protein_names_refseq": "CG9027-PD; Sod3-PD; superoxide dismutase 3, isoform D", "tax_id": 7227, "disease": "amyotrophic lateral sclerosis type 1 (Disease Ontology:DOID:0060193); atrial fibrillation (Disease Ontology:DOID:0060224); alcohol-associated liver disease (Disease Ontology:DOID:0070658); polycystic kidney disease (Disease Ontology:DOID:0080322); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); dry eye syndrome (Disease Ontology:DOID:10140); retinitis pigmentosa (Disease Ontology:DOID:10584); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); diabetic angiopathy (Disease Ontology:DOID:11713); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); retinopathy of prematurity (Disease Ontology:DOID:13025); Behcet's disease (Disease Ontology:DOID:13241); low tension glaucoma (Disease Ontology:DOID:13544); Down syndrome (Disease Ontology:DOID:14250); Parkinson's disease (Disease Ontology:DOID:14330); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); cystitis (Disease Ontology:DOID:1679); pancreatic cancer (Disease Ontology:DOID:1793); transient cerebral ischemia (Disease Ontology:DOID:224); motor neuron disease (Disease Ontology:DOID:231); renal artery obstruction (Disease Ontology:DOID:2972); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); hyperglycemia (Disease Ontology:DOID:4195); macular degeneration (Disease Ontology:DOID:4448); nutritional deficiency disease (Disease Ontology:DOID:5113); myocardial infarction (Disease Ontology:DOID:5844); prion disease (Disease Ontology:DOID:649); progressive supranuclear palsy (Disease Ontology:DOID:678); hyperthyroidism (Disease Ontology:DOID:7998); cataract (Disease Ontology:DOID:83); diabetic retinopathy (Disease Ontology:DOID:8947); cutaneous leishmaniasis (Disease Ontology:DOID:9111); ocular hypertension (Disease Ontology:DOID:9282); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dme:Dmel_CG9027); (R-DME-114608); (R-DME-3299685)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;21635891;25339624;25589440;26109356;26109357;33925313", "class_list": "", "function": "Protects the extracellular space from the toxic effects of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 41, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D8FT33;Q0E9C3;Q5U195;Q95T42", "ec_number_list": [ { "id": "1.15.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" } ], "go_molecular_function": "GO:0005507 copper ion binding;GO:0004784 superoxide dismutase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0019430 removal of superoxide radicals;GO:0009650 UV protection", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q7JR71-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0E9B6-1", "uniprot_id": [ { "id": "RS11_DROME", "url": "https://www.uniprot.org/uniprot/Q0E9B6", "type": "external" } ], "mass": 18105.0, "length": 155, "protein_name": "Small ribosomal subunit protein uS17", "gene_name": "RpS11", "organism": "Fruit fly", "refseq_name": "ribosomal protein S11, isoform C", "refseq_ac": [ { "id": "NP_725114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_725114", "type": "external" } ], "gene_names_uniprotkb": "RpS11; CG8857; Dmel\\CG8857; Dmel_CG8857; M(2)48E; RPS11; S11; S17; anon-EST:fe1D2; anon-MMS23; clone 23", "gene_names_refseq": "CG8857; Dmel\\CG8857; M(2)48E; RPS11; RpS11; S11; S17; anon-EST:fe1D2; anon-MMS23; clone 23", "protein_names_uniprotkb": "Small ribosomal subunit protein uS17; 40S ribosomal protein S11", "protein_names_refseq": "CG8857-PC; RpS11-PC; anon-fast-evolving-1D2; ribosomal protein S11, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8857); (R-DME-156827); (R-DME-1799339); (R-DME-6791226); (R-DME-72649); (R-DME-72689); (R-DME-72695); (R-DME-72702); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 13, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;23636399;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C4JD62;E2QC50", "ec_number_list": [], "go_molecular_function": "GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome;GO:0003723 RNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0022626 cytosolic ribosome;GO:0022627 cytosolic small ribosomal subunit;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q0E9B6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24560-1", "uniprot_id": [ { "id": "TBB1_DROME", "url": "https://www.uniprot.org/uniprot/Q24560", "type": "external" } ], "mass": 50147.0, "length": 447, "protein_name": "Tubulin beta-1 chain", "gene_name": "betaTub56D", "organism": "Fruit fly", "refseq_name": "beta-Tubulin at 56D, isoform B", "refseq_ac": [ { "id": "NP_523795", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523795", "type": "external" } ], "gene_names_uniprotkb": "betaTub56D; 1t; A1ZBL0_DROME; B1t; BETA 56D; BetaTub56D; CG9277; DTB2; Dmbeta1; Dmel\\CG9277; Dmel_CG9277; TBB1_DROME; TUB56D; Tub2D; Tub56D; Tubulin; Tub; T; beta tubulin; beta-Tub56D; beta-Tub; beta-tub 56D; beta-tub56D; beta-tubulin56D; beta-tubulin; beta-tub; beta1-Tubulin; beta1-tub; beta1Tub; beta1tub; beta1t; beta1; beta56D; betaTub1; betaTub56; betaTub; beta[[1]] tubulin; beta[[1]]-tubulin; betatub(56D); betatub56D; betatubulin; beta; l(2)k00705; tub56D; tubulin", "gene_names_refseq": "1t; A1ZBL0_DROME; B1t; BETA 56D; BetaTub56D; CG9277; DTB2; Dmbeta1; Dmel\\CG9277; TBB1_DROME; TUB56D; Tub2D; Tub56D; Tubulin; Tub; T; beta tubulin; beta-Tub56D; beta-Tub; beta-tub 56D; beta-tub56D; beta-tubulin56D; beta-tubulin; beta-tub; beta1-Tubulin; beta1-tub; beta1Tub; beta1tub; beta1t; beta1; beta56D; betaTub1; betaTub56D; betaTub56; betaTub; beta[[1]] tubulin; beta[[1]]-tubulin; betatub(56D); betatub56D; betatubulin; beta; l(2)k00705; tub56D; tubulin", "protein_names_uniprotkb": "Tubulin beta-1 chain; Beta-1-tubulin", "protein_names_refseq": "CG9277-PB; TUBULIN B-1 CHAIN; b-tubulin56D; beta tubulin; beta-1 tubulin; beta-1-tubulin; beta-Tubulin 56D; beta-Tubulin at 56 D; beta-Tubulin at 56D, isoform B; beta-tubulin-56D; beta1 tubulin; beta1-Tubulin; betaTub56D-PB; betatubulin; lethal (2) k00705; tubulin beta-1 chain; tubulin beta1-chain", "tax_id": 7227, "disease": "cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome (Disease Ontology:DOID:0050997); ptosis (Disease Ontology:DOID:0060260); hypomyelinating leukodystrophy 6 (Disease Ontology:DOID:0060798); torsion dystonia 4 (Disease Ontology:DOID:0090041); complex cortical dysplasia with other brain malformations 7 (Disease Ontology:DOID:0090132); complex cortical dysplasia with other brain malformations 5 (Disease Ontology:DOID:0090135); complex cortical dysplasia with other brain malformations 6 (Disease Ontology:DOID:0090136); tubulinopathy (Disease Ontology:DOID:0112227); Leber congenital amaurosis with early-onset deafness (Disease Ontology:DOID:0112240); congenital symmetric circumferential skin creases 1 (Disease Ontology:DOID:0112242); microcephaly (Disease Ontology:DOID:10907); facial paralysis (Disease Ontology:DOID:13934); demyelinating disease (Disease Ontology:DOID:3213)", "pathway": " (dme:Dmel_CG9277); (R-DME-3371497); (R-DME-6798695); (R-DME-6807878); (R-DME-6811436)", "pathway_count": 5, "publication_count": 15, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;18327897;22451918;25589440;26109356;26109357;3119300;32066907", "class_list": "", "function": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q53YG6;Q9V8V4", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0000226 microtubule cytoskeleton organization;GO:0007017 microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q24560-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9NLA6-1", "uniprot_id": [ { "id": "OAF_DROME", "url": "https://www.uniprot.org/uniprot/Q9NLA6", "type": "external" } ], "mass": 53730.0, "length": 487, "protein_name": "Out at first protein", "gene_name": "oaf", "organism": "Fruit fly", "refseq_name": "out at first, isoform A", "refseq_ac": [ { "id": "NP_477040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477040", "type": "external" } ], "gene_names_uniprotkb": "oaf; CG9884; Dmel\\CG9884; Dmel_CG9884; l(2)22Fb; l(2)ND1; tnd", "gene_names_refseq": "CG9884; Dmel\\CG9884; l(2)22Fb; l(2)ND1; oaf; tnd", "protein_names_uniprotkb": "Out at first protein", "protein_names_refseq": "CG9884-PA; near dpp complementation group 1; oaf-PA; out at first, isoform A; transcript near decapentaplegic; transcript-near-decapentaplegic", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9884)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;7768442;8675012", "class_list": "", "function": "Vital for proper neuronal development and hatching., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q24556;Q86CS3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9NLA6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50534-1", "uniprot_id": [ { "id": "MSL2_DROME", "url": "https://www.uniprot.org/uniprot/P50534", "type": "external" } ], "mass": 84856.0, "length": 773, "protein_name": "E3 ubiquitin-protein ligase msl-2", "gene_name": "msl-2", "organism": "Fruit fly", "refseq_name": "male-specific lethal 2, isoform A", "refseq_ac": [ { "id": "NP_523467", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523467", "type": "external" } ], "gene_names_uniprotkb": "msl-2; CG3241; Dmel\\CG3241; Dmel_CG3241; MSL-2; MSL2; MSL; Msl 1-3; Msl-2; Msl2; km(2)A; kmA; msl2; msl", "gene_names_refseq": "CG3241; Dmel\\CG3241; MSL-2; MSL2; MSL; Msl 1-3; Msl-2; Msl2; km(2)A; kmA; msl-2; msl2; msl", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase msl-2; 2.3.2.27; Protein male-specific lethal-2", "protein_names_refseq": "CG3241-PA; Male-Specific lethal 2; killer of males; killer-of-males-A; male specifc lethal; male specific lethal 2; male specific-lethal 2; male-specific lethal 2, isoform A; male-specific-lethal 2; male-specific-lethal-2; males specific lethal 2; msl-2-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3241); (R-DME-3214847)", "pathway_count": 2, "publication_count": 37, "publication_id_list": "10617208;10679323;10731132;11014199;12537568;12537569;12537572;12537573;12537574;16110336;16543150;17569856;17569867;18086881;18724933;20139418;21551218;21726816;23029009;23084834;23084835;23870142;25452275;25589440;26109356;26109357;27580037;28510597;31320325;33208948;35648444;37602401;7588059;7781064;7796814;9144292;9182767", "class_list": "", "function": "Limiting component of the male-specific lethal (MSL) histone acetyltransferase complex, a multiprotein complex essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation) (PubMed:18724933, PubMed:23084835, PubMed:23870142, PubMed:27580037, PubMed:31320325, PubMed:33208948, PubMed:7588059, PubMed:7781064, PubMed:7796814). The MSL complex specifically associates with the single X chromosome in males and mediates formation of H4K16ac, promoting a two-fold activation of X chromosome (PubMed:16543150). Msl-2 is only produced in males, constituting the limiting component of the MSL complex (PubMed:7781064). Within the MSL complex, msl-2 mediates the selective binding to the X chromosome and recruitment of the MSL complex via two different mechanisms (PubMed:18724933, PubMed:20139418, PubMed:25452275, PubMed:27580037, PubMed:31320325, PubMed:33208948, PubMed:37602401). Recognizes DNA motifs that are enriched on X chromosome, named PionX sites, which are characterized by sequence features and distinct DNA conformation (base roll) (PubMed:18724933, PubMed:25452275, PubMed:27580037, PubMed:31320325, PubMed:37602401). Specific recognition of the X chromosome is also mediated by the formation of a gel-like state: msl-2 undergoes liquid-liquid phase separation upon binding to roX1 and roX2 non-coding RNAs, leading to nucleate the MSL complex on the X chromosome (PubMed:33208948). Msl-2 is also required for translation and/or stability of msl-1 in males (PubMed:7588059, PubMed:7781064, PubMed:7796814). Also acts as an E3 ubiquitin ligase: in complex with msl-1, mediates ubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816). Also catalyzes ubiquitination of msl-1, msl-3 and mof components of the MSL complex (PubMed:23084834, PubMed:28510597)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 17, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VQR1", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005694 chromosome;GO:0000228 nuclear chromosome;GO:0072487 MSL complex;GO:0000805 X chromosome;GO:0046536 dosage compensation complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination;GO:0071168 protein localization to chromatin;GO:0009047 dosage compensation by hyperactivation of X chromosome", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "P50534-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V3U9-1", "uniprot_id": [ { "id": "SLMO_DROME", "url": "https://www.uniprot.org/uniprot/Q9V3U9", "type": "external" } ], "mass": 24305.0, "length": 215, "protein_name": "Protein slowmo", "gene_name": "slmo", "organism": "Fruit fly", "refseq_name": "slowmo, isoform C", "refseq_ac": [ { "id": "NP_001097094", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097094", "type": "external" } ], "gene_names_uniprotkb": "slmo; CG9131; CT26166; Dmel\\CG9131; Dmel_CG9131; kisir", "gene_names_refseq": "CG9131; CT26166; Dmel\\CG9131; kisir; slmo", "protein_names_uniprotkb": "Protein slowmo", "protein_names_refseq": "CG9131-PC; kisir; slmo-PC; slowmo, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9131); (R-DME-6803204)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;14673704;16110336;17245774;17569856;17569867;25589440;26109356;26109357;40245499", "class_list": "", "function": "Required to regulate peristaltic movement and also for germline proliferation in males and females., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q058T1", "ec_number_list": [], "go_molecular_function": "GO:1990050 phosphatidic acid transfer activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0030432 peristalsis;GO:0007283 spermatogenesis;GO:0015914 phospholipid transport;GO:0008345 larval locomotory behavior;GO:0030706 germarium-derived oocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9V3U9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IPH9-1", "uniprot_id": [ { "id": "SLOB_DROME", "url": "https://www.uniprot.org/uniprot/Q8IPH9", "type": "external" } ], "mass": 57924.0, "length": 515, "protein_name": "Slowpoke-binding protein", "gene_name": "Slob", "organism": "Fruit fly", "refseq_name": "slowpoke binding protein, isoform D", "refseq_ac": [ { "id": "NP_001033881", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033881", "type": "external" } ], "gene_names_uniprotkb": "Slob; CG13792; CG43756; CG6772; Dmel\\CG43756; Dmel_CG43756; SLOB; slob", "gene_names_refseq": "CG13792; CG43756; CG6772; Dmel\\CG43756; SLOB; Slob; slob", "protein_names_uniprotkb": "Slowpoke-binding protein", "protein_names_refseq": "CG43756-PD; SLO-binding protein; SLOWPOKE-binding protein; Slob-PD; giant slob; slowpoke binding protein, isoform D; slowpoke channel binding protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG43756)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10230800;10731132;11719206;12537568;12537569;12537572;12537573;12537574;14529710;15234468;16110336;17569856;17569867;25589440;26109356;26109357;9539129", "class_list": "", "function": "Regulator of calcium-activated channel Slo. Increases or decreases the voltage sensitivity of Slo, depending on the absence or presence of 14-3-3-zeta in the complex, respectively., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O61564;Q5BIJ6;Q95SL3;Q9VLZ4", "ec_number_list": [], "go_molecular_function": "GO:0004672 protein kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045202 synapse", "go_biological_process": "GO:0007274 neuromuscular synaptic transmission;GO:0042391 regulation of membrane potential;GO:0042594 response to starvation;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8IPH9-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24509-1", "uniprot_id": [ { "id": "STX5_DROME", "url": "https://www.uniprot.org/uniprot/Q24509", "type": "external" } ], "mass": 51850.0, "length": 467, "protein_name": "Syntaxin-5", "gene_name": "Syx5", "organism": "Fruit fly", "refseq_name": "syntaxin 5, isoform B", "refseq_ac": [ { "id": "NP_523582", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523582", "type": "external" } ], "gene_names_uniprotkb": "Syx5; BG:DS02740.12; CG4214; DmSyx5; Dmel\\CG4214; Dmel_CG4214; II; SED5; STX5; SYN5; Sed5; Synx5; Syx5A; Syx; anon-35Fb; anon-35Fd; dSed5p; dSed5; dSyx5; dsed5; l(2)35Ff; sed5; syn5; syx5", "gene_names_refseq": "BG:DS02740.12; CG4214; DmSyx5; Dmel\\CG4214; II; SED5; STX5; SYN5; Sed5; Synx5; Syx5A; Syx5; Syx; anon-35Fb; anon-35Fd; dSed5p; dSed5; dSyx5; dsed5; l(2)35Ff; sed5; syn5; syx5", "protein_names_uniprotkb": "Syntaxin-5; Sed5 protein; dSed5", "protein_names_refseq": "CG4214-PB; Syntaxin5; Syx5-PB; dSyntaxin5; lethal(2)35Ff; syntaxin 5, isoform B; syntaxin 5; syntaxin", "tax_id": 7227, "disease": "congenital disorder of glycosylation type II (Disease Ontology:DOID:0050571)", "pathway": " (dme:Dmel_CG4214); (R-DME-204005); (R-DME-5694530); (R-DME-6807878); (R-DME-6811438); (R-DME-9609523)", "pathway_count": 6, "publication_count": 14, "publication_id_list": "10471707;10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;7929581", "class_list": "", "function": "Mediates endoplasmic reticulum to Golgi transport., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7KW50;Q8T9C1", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0012505 endomembrane system;GO:0005801 cis-Golgi network;GO:0031201 SNARE complex", "go_biological_process": "GO:0006878 intracellular copper ion homeostasis;GO:0006886 intracellular protein transport;GO:0007283 spermatogenesis;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q24509-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8T6B9-1", "uniprot_id": [ { "id": "PUF68_DROME", "url": "https://www.uniprot.org/uniprot/Q8T6B9", "type": "external" } ], "mass": 67940.0, "length": 637, "protein_name": "Poly(U)-binding-splicing factor hfp", "gene_name": "hfp", "organism": "Fruit fly", "refseq_name": "half pint, isoform E", "refseq_ac": [ { "id": "NP_001163315", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163315", "type": "external" } ], "gene_names_uniprotkb": "hfp; CG12085; DPUF68; Dmel\\CG12085; Dmel_CG12085; Fir; HFP; Hfp; PUF60; PUF68; Puf60; Puf68; anon-WO0118547.408; dFIR; pUF68; pUbsf; pUf68; puf68", "gene_names_refseq": "CG12085; DPUF68; Dmel\\CG12085; Fir; HFP; Hfp; PUF60; PUF68; Puf60; Puf68; anon-WO0118547.408; dFIR; hfp; pUF68; pUbsf; pUf68; puf68", "protein_names_uniprotkb": "Poly(U)-binding-splicing factor hfp; 68 kDa poly(U)-binding-splicing factor; PUF60 homolog; Protein half pint", "protein_names_refseq": "CG12085-PE; half pint, isoform E; half pint; half-pint; hfp-PE; poly U binding factor 68kD; polyU binding splicing factor", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12085); (R-DME-72163); (R-DME-9770562); (R-DME-9943411)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "10606266;10731132;11879639;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;37027460", "class_list": "", "function": "Splicing factor that regulates oogenesis and controls both mitosis and mRNA localization in the germline by regulating mRNA splicing of a subset of genes within the ovary (PubMed:11879639). Probably acts by regulating the alternative splice site selection of the otu transcript (PubMed:11879639). Also regulates the alternative splicing of eIF4E1 and grk, while it is not involved in the splicing of par-1, sqd or psq (PubMed:11879639). Involved in the alternative splicing of the bicistronic pre-mRNA encoding Kdm3 and CG8176; required for the efficient production of mRNA encoding Kdm3 and Kdm3-mediated regulation of rhino-dependent piRNA production (PubMed:37027460)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0E8J8;Q95S11;Q9U696;Q9W0E6;Q9W0E7", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0071013 catalytic step 2 spliceosome;GO:0032991 protein-containing complex;GO:0071011 precatalytic spliceosome", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0001558 regulation of cell growth;GO:0000398 mRNA splicing, via spliceosome;GO:0048477 oogenesis;GO:0006376 mRNA splice site recognition", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8T6B9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P91929-1", "uniprot_id": [ { "id": "NDUAA_DROME", "url": "https://www.uniprot.org/uniprot/P91929", "type": "external" } ], "mass": 46898.0, "length": 407, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial", "gene_name": "ND-42", "organism": "Fruit fly", "refseq_name": "NADH dehydrogenase (ubiquinone) 42 kDa subunit, isoform C", "refseq_ac": [ { "id": "NP_001262821", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262821", "type": "external" } ], "gene_names_uniprotkb": "ND-42; A10; CG6343; Dmel\\CG6343; Dmel_CG6343; ND42; NDUFA10; NUDM; NdufA10; dNDUFA10", "gene_names_refseq": "A10; CG6343; Dmel\\CG6343; ND-42; ND42; NDUFA10; NUDM; NdufA10; dNDUFA10", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial; CI-42kD; Complex I-42kD; NADH-ubiquinone oxidoreductase 42 kDa subunit", "protein_names_refseq": "CG6343-PC; NADH dehydrogenase (ubiquinone) 42 kDa subunit, isoform C; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10; NADH ubiquinone oxidoreductase 42 kDa; NADH-ubiquinone oxidoreductase 42 kDa subunit; NADH-ubiquinone oxidoreductase subunit; NADH: UBIQUINONE REDUCTASE 42 KD SUBUNIT PRECURSOR; NADH:ubiquinone oxidoreductase 42 kDa subunit; NADH:ubiquinone reductase 42 kD; NADH:ubiquinone reductase 42kD subunit precursor; ND-42-PC", "tax_id": 7227, "disease": "nuclear type mitochondrial complex I deficiency 22 (Disease Ontology:DOID:0112069)", "pathway": " (dme:Dmel_CG6343); (R-DME-611105); (R-DME-6799198)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "10071211;10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;23509070;24652937;25412178;25589440;25594180;26109356;26109357;28683319", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VD54", "ec_number_list": [], "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P91929-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KRY6-1", "uniprot_id": [ { "id": "NHK1_DROME", "url": "https://www.uniprot.org/uniprot/Q7KRY6", "type": "external" } ], "mass": 65994.0, "length": 599, "protein_name": "Nucleosomal histone kinase 1", "gene_name": "ball", "organism": "Fruit fly", "refseq_name": "ballchen, isoform A", "refseq_ac": [ { "id": "NP_651508", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651508", "type": "external" } ], "gene_names_uniprotkb": "ball; BALL; Ball; BcDNA:LD09009; CG6386; Dmel\\CG6386; Dmel_CG6386; NHK-1; NHK1; VRK; ballchen; nhk-1; trip", "gene_names_refseq": "BALL; Ball; BcDNA:LD09009; CG6386; Dmel\\CG6386; NHK-1; NHK1; VRK; ball; nhk-1; trip", "protein_names_uniprotkb": "Nucleosomal histone kinase 1; 2.7.11.1; Protein baellchen", "protein_names_refseq": "CG6386-PA; ball-PA; ballchen, isoform A; ballchen; nuclear histone kinase-1; nucleosomal histone kinase-1; triplet", "tax_id": 7227, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); pontocerebellar hypoplasia type 1A (Disease Ontology:DOID:0060265); autosomal recessive distal hereditary motor neuronopathy 10 (Disease Ontology:DOID:0081429)", "pathway": " (dme:Dmel_CG6386); (R-DME-2995383)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15078818;16110336;16230526;16301329;17569856;17569867;18327897;25589440;26109356;26109357;26251439;31735666", "class_list": "", "function": "Serine/threonine-protein kinase involved in somatic mitosis and female meiosis (PubMed:16230526). Required for spindle organization in mitosis, and for the establishment or maintenance of meiosis-specific chromosomal configurations, including the prophase I karyosome and the metaphase I spindle (PubMed:15078818, PubMed:16301329). Specifically phosphorylates nucleosomal H2A on 'Thr-119' (PubMed:15078818). Required for the development and organization of indirect flight muscle sarcomeres by regulating the formation of M line and H zone and the correct assembly of thick and thin filaments in the sarcomere (PubMed:26251439)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9U9Q0;Q9VBB2", "ec_number_list": [ { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "5.6.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.8", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0030017 sarcomere;GO:0030018 Z disc", "go_biological_process": "GO:0007165 signal transduction;GO:0043687 post-translational protein modification;GO:0051301 cell division;GO:0006974 DNA damage response;GO:0007143 female meiotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q7KRY6-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02926-1", "uniprot_id": [ { "id": "RB97D_DROME", "url": "https://www.uniprot.org/uniprot/Q02926", "type": "external" } ], "mass": 51476.0, "length": 471, "protein_name": "Ribonucleoprotein RB97D", "gene_name": "Rb97D", "organism": "Fruit fly", "refseq_name": "ribonuclear protein at 97D, isoform I", "refseq_ac": [ { "id": "NP_001014671", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014671", "type": "external" } ], "gene_names_uniprotkb": "Rb97D; CG6354; Dmel\\CG6354; Dmel_CG6354; Hrb97D; R16; RBP97D; Rb97D1; ms(3)03445; rb97d; rbf", "gene_names_refseq": "CG6354; Dmel\\CG6354; Hrb97D; R16; RBP97D; Rb97D1; Rb97D; ms(3)03445; rb97d; rbf", "protein_names_uniprotkb": "Ribonucleoprotein RB97D", "protein_names_refseq": "CG6354-PI; Rb97D-PI; ribonuclear protein at 97D, isoform I", "tax_id": 7227, "disease": "gastric adenocarcinoma (Disease Ontology:DOID:3717)", "pathway": " (dme:Dmel_CG6354)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8502565", "class_list": "", "function": "Required for spermatogenesis. Could be required to process a specific transcript essential for spermatogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8IHB8;Q9VBA9", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0098687 chromosomal region", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q02926-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KRW1-1", "uniprot_id": [ { "id": "TRC8_DROME", "url": "https://www.uniprot.org/uniprot/Q7KRW1", "type": "external" } ], "mass": 89235.0, "length": 809, "protein_name": "Protein TRC8 homolog", "gene_name": "Trc8", "organism": "Fruit fly", "refseq_name": "TRC8 ring finger protein, isoform E", "refseq_ac": [ { "id": "NP_001263070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263070", "type": "external" } ], "gene_names_uniprotkb": "Trc8; CG2304; DTrc8; Dmel\\CG2304; Dmel_CG2304; Dtrc8; TRC8; trc8", "gene_names_refseq": "CG2304; DTrc8; Dmel\\CG2304; Dtrc8; TRC8; Trc8; trc8", "protein_names_uniprotkb": "Protein TRC8 homolog", "protein_names_refseq": "CG2304-PE; TRC8 ortholog; TRC8 ring finger protein, isoform E; Trc8-PE", "tax_id": 7227, "disease": "renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (dme:Dmel_CG2304)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;12032852;12537568;12537569;12537572;12537573;12537574;15735686;16110336;17569856;17569867;20068067;25589440;26109356;26109357", "class_list": "", "function": "Plays a role in growth inhibition that is dependent upon COP9 signalosome subunits CSN5 and CSN6. May modulate signalosome levels or compartmentalization. Probably functions in the same or a related pathway to VHL during early midline development., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7KRW0;Q8IHG9;Q8MQX1;Q8T0E3;Q8WRY2;Q9VAK6", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0012505 endomembrane system;GO:0036513 Derlin-1 retrotranslocation complex;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007418 ventral midline development;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0036503 ERAD pathway;GO:0045926 negative regulation of growth", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q7KRW1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VAF0-1", "uniprot_id": [ { "id": "S39AD_DROME", "url": "https://www.uniprot.org/uniprot/Q9VAF0", "type": "external" } ], "mass": 38870.0, "length": 355, "protein_name": "Zinc transporter ZIP13 homolog", "gene_name": "Zip99C", "organism": "Fruit fly", "refseq_name": "Zinc/iron regulated transporter-related protein 99C, isoform H", "refseq_ac": [ { "id": "NP_001189313", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001189313", "type": "external" } ], "gene_names_uniprotkb": "Zip99C; CG7816; Dmel\\CG7816; Dmel_CG7816; ZIP13; ZIP99C; Zip13; cg7816; dZIP13; dZip13; dZip99C", "gene_names_refseq": "CG7816; Dmel\\CG7816; ZIP13; ZIP99C; Zip13; Zip99C; cg7816; dZIP13; dZip13; dZip99C", "protein_names_uniprotkb": "Zinc transporter ZIP13 homolog; Zinc/iron regulated transporter-related protein 99C", "protein_names_refseq": "CG7816-PH; Zinc/iron regulated transporter-related protein 99C, isoform H; Zip99C-PH", "tax_id": 7227, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); Ehlers-Danlos syndrome spondylodysplastic type 3 (Disease Ontology:DOID:0080739); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359)", "pathway": " (dme:Dmel_CG7816)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;23322169;25589440;26109356;26109357", "class_list": "", "function": "Involved in zinc transport and homeostasis., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q53YH2", "ec_number_list": [], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0005506 iron ion binding;GO:0005381 iron ion transmembrane transporter activity;GO:0046873 metal ion transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016323 basolateral plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0010312 detoxification of zinc ion;GO:0071577 zinc ion transmembrane transport;GO:0006882 intracellular zinc ion homeostasis;GO:0006826 iron ion transport;GO:0060586 multicellular organismal-level iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VAF0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24524-1", "uniprot_id": [ { "id": "SING_DROME", "url": "https://www.uniprot.org/uniprot/Q24524", "type": "external" } ], "mass": 57279.0, "length": 512, "protein_name": "Protein singed", "gene_name": "sn", "organism": "Fruit fly", "refseq_name": "singed, isoform E", "refseq_ac": [ { "id": "NP_001162697", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162697", "type": "external" } ], "gene_names_uniprotkb": "sn; CG15331; CG1536; CG32858; Dmel\\CG32858; Dmel_CG32858; Fascin; Fscn; SN; Singed; Sn; fascin; fs(1)A1057; fs(1)K1421; fs(1)K418; fs(1)K473; fs(1)K743; fs(1)M45; fscn", "gene_names_refseq": "CG15331; CG1536; CG32858; Dmel\\CG32858; Fascin; Fscn; SN; Singed; Sn; fascin; fs(1)A1057; fs(1)K1421; fs(1)K418; fs(1)K473; fs(1)K743; fs(1)M45; fscn; sn", "protein_names_uniprotkb": "Protein singed", "protein_names_refseq": "CG32858-PE; fascin; singed, isoform E; singed; sn-PE", "tax_id": 7227, "disease": "retinitis pigmentosa 30 (Disease Ontology:DOID:0110406); retinitis pigmentosa (Disease Ontology:DOID:10584); pancreatic cancer (Disease Ontology:DOID:1793); auditory system disease (Disease Ontology:DOID:2742); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); common bile duct neoplasm (Disease Ontology:DOID:4608); cholangiocarcinoma (Disease Ontology:DOID:4947); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (dme:Dmel_CG32858)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;1723709;17569856;17569867;19729655;25589440;26109356;26109357;27578797", "class_list": "", "function": "Acts as an actin bundling protein (PubMed:1723709, PubMed:19729655). May have a role in the asymmetric organization and/or movement of cytoplasmic components (PubMed:1723709). It has a role in somatic cells during the formation of adult bristles and hairs, and in the female germline during oogenesis (PubMed:1723709, PubMed:19729655)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W3L8", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0030674 protein-macromolecule adaptor activity;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0043025 neuronal cell body;GO:0043005 neuron projection;GO:0005856 cytoskeleton", "go_biological_process": "GO:0009913 epidermal cell differentiation;GO:0016358 dendrite development;GO:0016477 cell migration;GO:0046847 filopodium assembly;GO:0048812 neuron projection morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q24524-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04499-1", "uniprot_id": [ { "id": "PROD_DROME", "url": "https://www.uniprot.org/uniprot/Q04499", "type": "external" } ], "mass": 77153.0, "length": 681, "protein_name": "Proline dehydrogenase 1, mitochondrial", "gene_name": "slgA", "organism": "Fruit fly", "refseq_name": "sluggish A, isoform I", "refseq_ac": [ { "id": "NP_001245791", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245791", "type": "external" } ], "gene_names_uniprotkb": "slgA; CG1417; Dmel\\CG1417; Dmel_CG1417; EE85; PRODH; slg; sl; tu3", "gene_names_refseq": "CG1417; Dmel\\CG1417; EE85; PRODH; slgA; slg; sl; tu3", "protein_names_uniprotkb": "Proline dehydrogenase 1, mitochondrial; 1.5.5.2; Proline oxidase; Protein sluggish-A", "protein_names_refseq": "CG1417-PI; proline dehydrogenase; slgA-PI; sluggish A, isoform I; sluggish-A; sluggishA", "tax_id": 7227, "disease": "chromosome 22q11.2 deletion syndrome, distal (Disease Ontology:DOID:0060413); schizophrenia 4 (Disease Ontology:DOID:0070080); hyperprolinemia type 1 (Disease Ontology:DOID:0080542); schizophrenia (Disease Ontology:DOID:5419); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (dme:Dmel_CG1417); (R-DME-389661); (R-DME-70688)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8096642;9520435", "class_list": "", "function": "Converts proline to delta-1-pyrroline-5-carboxylate (PubMed:8096642). Involved in the conversion of proline to glutamate, which functions as a transmitter at neuromuscular junctions (PubMed:8096642). Glutamate deficiency could possibly account for reduced motor activity (PubMed:8096642)., [UniProtKB, PubMed]; Converts proline to delta-1-pyrroline-5-carboxylate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O61349;Q8IQ45;Q8IQ46;Q8T0C7;Q9VRH7;Q9VRH8;Q9VRH9;Q9VRI2", "ec_number_list": [ { "id": "1.5.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.5.2", "type": "external" } ], "go_molecular_function": "GO:0071949 FAD binding;GO:0004657 proline dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0007626 locomotory behavior;GO:0006562 L-proline catabolic process;GO:0010133 L-proline catabolic process to L-glutamate;GO:0002118 aggressive behavior;GO:0042331 phototaxis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q04499-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24211-1", "uniprot_id": [ { "id": "STNA_DROME", "url": "https://www.uniprot.org/uniprot/Q24211", "type": "external" } ], "mass": 93109.0, "length": 850, "protein_name": "Protein stoned-A", "gene_name": "stnA", "organism": "Fruit fly", "refseq_name": "stoned A, isoform C", "refseq_ac": [ { "id": "NP_001036316", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036316", "type": "external" } ], "gene_names_uniprotkb": "stnA; 20; 31; 32; 8P1; CG12500; CG40306; Dmel\\CG12500; Dmel_CG12500; ORF1; STNA; StnA; X-3; X-43; X3; l(1)13-20; l(1)20Bc; l(1)X-3; l8P1; lR9-10; sesC; stn-A; stn; x-3", "gene_names_refseq": "20; 31; 32; 8P1; CG12500; CG40306; Dmel\\CG12500; ORF1; STNA; StnA; X-3; X-43; X3; l(1)13-20; l(1)20Bc; l(1)X-3; l8P1; lR9-10; sesC; stn-A; stnA; stn; x-3", "protein_names_uniprotkb": "Protein stoned-A; Stn-A; StonedA", "protein_names_refseq": "CG12500-PC; section 20; section 31; section 32; stnA-PC; stoned A, isoform C; stonedA; stress-sensitive-C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12500)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10407025;10731132;11069931;11160392;11312288;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8844157;9822725", "class_list": "", "function": "Adapter protein involved in endocytic recycling of synaptic vesicles membranes. May act by mediating the retrieval of synaptotagmin protein Syt from the plasma membrane, thereby facilitating the internalization of multiple synaptic vesicles from the plasma membrane., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7PLF2;Q9W5M8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0030139 endocytic vesicle;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0048488 synaptic vesicle endocytosis;GO:0048489 synaptic vesicle transport", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q24211-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V3X5-1", "uniprot_id": [ { "id": "TMTC2_DROME", "url": "https://www.uniprot.org/uniprot/Q9V3X5", "type": "external" } ], "mass": 103091.0, "length": 938, "protein_name": "Protein O-mannosyl-transferase Tmtc2", "gene_name": "Tmtc2", "organism": "Fruit fly", "refseq_name": "transmembrane O-mannosyltransferase targeting cadherins 2, isoform A", "refseq_ac": [ { "id": "NP_608558", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608558", "type": "external" } ], "gene_names_uniprotkb": "Tmtc2; BcDNA:GH12144; CG4341; Dmel\\CG4341; Dmel_CG4341; TMTC2", "gene_names_refseq": "BcDNA:GH12144; CG4341; Dmel\\CG4341; TMTC2; Tmtc2", "protein_names_uniprotkb": "Protein O-mannosyl-transferase Tmtc2; 2.4.1.109; Transmembrane O-mannosyltransferase targeting cadherins 2; Transmembrane and tetratricopeptide repeat-containing 2", "protein_names_refseq": "CG4341-PA; Tmtc2-PA; transmembrane O-mannosyltransferase targeting cadherins 2, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4341)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Transfers mannosyl residues to the hydroxyl group of serine or threonine residues., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.109", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.109", "type": "external" } ], "go_molecular_function": "GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0000030 mannosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0035269 protein O-linked glycosylation via mannose", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9V3X5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q95RR8-1", "uniprot_id": [ { "id": "PAN3_DROME", "url": "https://www.uniprot.org/uniprot/Q95RR8", "type": "external" } ], "mass": 85391.0, "length": 790, "protein_name": "PAN2-PAN3 deadenylation complex subunit PAN3", "gene_name": "PAN3", "organism": "Fruit fly", "refseq_name": "Poly(A) specific ribonuclease subunit PAN3, isoform G", "refseq_ac": [ { "id": "NP_647767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647767", "type": "external" } ], "gene_names_uniprotkb": "PAN3; CG11486; Dmel\\CG11486; Dmel_CG11486; Pan3; pan3", "gene_names_refseq": "CG11486; Dmel\\CG11486; PAN3; Pan3; pan3", "protein_names_uniprotkb": "PAN2-PAN3 deadenylation complex subunit PAN3; PAB1P-dependent poly(A)-specific ribonuclease; PAN deadenylation complex subunit 3; Poly(A)-nuclease deadenylation complex subunit 3", "protein_names_refseq": "CG11486-PG; PAN3-PG; Poly(A) specific ribonuclease subunit PAN3, isoform G; polyA-nuclease related", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11486); (R-DME-429947)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;21981923;23172285;23932717;25589440;26109356;26109357;31114929;33925313", "class_list": "", "function": "Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008143 poly(A) binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000932 P-body;GO:0031251 PAN complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly;GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q95RR8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KTX8-1", "uniprot_id": [ { "id": "MED13_DROME", "url": "https://www.uniprot.org/uniprot/Q7KTX8", "type": "external" } ], "mass": 280024.0, "length": 2618, "protein_name": "Mediator of RNA polymerase II transcription subunit 13", "gene_name": "skd", "organism": "Fruit fly", "refseq_name": "skuld, isoform D", "refseq_ac": [ { "id": "NP_524653", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524653", "type": "external" } ], "gene_names_uniprotkb": "skd; Bli; CG9936; Dmel\\CG9936; Dmel_CG9936; LD28662; MED13; Med13; Pap; SKD; SPH203; Scad78; Skd; TRAP240; Trap240; Trap; bli; bls; dMED13; dTRAP240; dTrap240; dmMED13; l(3)L7062; l(3)rK760; pap; siren9", "gene_names_refseq": "CG9936; Dmel\\CG9936; LD28662; MED13; Med13; Pap/Trap; Pap; SKD; SPH203; Scad78; Skd/Med13; Skd/Pap/Bli; Skd; Srb9/AMIB/PAP/TRAP240; TRAP240; Trap240; bli; bls; dMED13; dTRAP240; dTrap240; dmMED13; l(3)L7062; l(3)rK760; pap/dTRAP240; pap; siren9; skd/MED13; skd", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 13; Mediator complex subunit 13; Mediator complex subunit Skuld; Protein blind spot; Protein poils aux pattes; dTRAP240", "protein_names_refseq": "CG9936-PD; blind spot; flytrap; mediator complex subunit 13; poils aux pattes; skd-PD; skuld, isoform D; skuld; suppressor of constitutively activated Dpp signaling 78", "tax_id": 7227, "disease": "dextro-looped transposition of the great arteries (Disease Ontology:DOID:0060770); autosomal dominant intellectual developmental disorder 61 (Disease Ontology:DOID:0061034); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG9936); (R-DME-9841922)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10731132;11090137;11171343;12537568;12537569;12537572;12537573;12537574;12835386;16110336;16751183;17290221;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors., [UniProtKB, UniProtKB, UniProtKB]; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for leg and eye development and macrochaete specification or differentiation. Negatively regulates sex comb development. Required for activated transcription of the MtnB and MtnD genes., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q95RI1", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016592 mediator complex;GO:0070847 core mediator complex;GO:1990508 CKM complex", "go_biological_process": "GO:0048749 compound eye development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q7KTX8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q95YI5-1", "uniprot_id": [ { "id": "US74C_DROME", "url": "https://www.uniprot.org/uniprot/Q95YI5", "type": "external" } ], "mass": 41182.0, "length": 373, "protein_name": "UDP-sugar transporter UST74c", "gene_name": "frc", "organism": "Fruit fly", "refseq_name": "fringe connection, isoform B", "refseq_ac": [ { "id": "NP_001137962", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137962", "type": "external" } ], "gene_names_uniprotkb": "frc; CG3874; Dmel\\CG3874; Dmel_CG3874; FRC; Frc; UDP-GlcUA; UST74C; anon-WO0172774.5; anon-WO0172774.7; dFRC; l(3)00073; l(3)02619; l(3)10098; l(3)L6750; l(3)S070006; l(3)j2E3; ust74C", "gene_names_refseq": "CG3874; Dmel\\CG3874; FRC; Frc; UDP-GlcNAc/UDP-GlcUA; UST74C; anon-WO0172774.5; anon-WO0172774.7; dFRC; frc; l(3)00073; l(3)02619; l(3)10098; l(3)L6750; l(3)S070006; l(3)j2E3; ust74C", "protein_names_uniprotkb": "UDP-sugar transporter UST74c; Protein fringe connection", "protein_names_refseq": "CG3874-PB; Fringe-connection; UDP-sugar transporter in 74C; frc-PB; fringe connection, isoform B; fringe connection", "tax_id": 7227, "disease": "schneckenbecken dysplasia (Disease Ontology:DOID:0050775); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (dme:Dmel_CG3874); (R-DME-173599); (R-DME-2022854); (R-DME-2022928); (R-DME-727802)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "10731132;11533661;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Involved in the import of UDP-sugars from the cytoplasm into the Golgi lumen., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VVG8", "ec_number_list": [], "go_molecular_function": "GO:0015297 antiporter activity;GO:0005461 UDP-glucuronate transmembrane transporter activity;GO:0005459 UDP-galactose transmembrane transporter activity;GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity;GO:0005464 UDP-xylose transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005797 Golgi medial cisterna;GO:0016020 membrane", "go_biological_process": "GO:0015786 UDP-glucose transmembrane transport;GO:0015790 UDP-xylose transmembrane transport;GO:0009880 embryonic pattern specification;GO:0007423 sensory organ development;GO:0072334 UDP-galactose transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q95YI5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9GN97-1", "uniprot_id": [ { "id": "PGPLD_DROME", "url": "https://www.uniprot.org/uniprot/Q9GN97", "type": "external" } ], "mass": 31104.0, "length": 282, "protein_name": "Peptidoglycan-recognition protein LD", "gene_name": "PGRP-LD", "organism": "Fruit fly", "refseq_name": "peptidoglycan recognition protein LD, isoform C", "refseq_ac": [ { "id": "NP_001027111", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027111", "type": "external" } ], "gene_names_uniprotkb": "PGRP-LD; CG32912; CG33717; CG5523; Dmel\\CG33717; Dmel_CG33717", "gene_names_refseq": "CG32912; CG33717; CG5523; Dmel\\CG33717; PGRP-LD", "protein_names_uniprotkb": "Peptidoglycan-recognition protein LD", "protein_names_refseq": "CG33717-PC; PGRP-LD-PC; peptidoglycan recognition protein LD, isoform C; peptidoglycan recognition protein-LD", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33717); (R-DME-6798695); (R-DME-6803157)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10731132;11106397;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Peptidoglycan-recognition protein probably involved in innate immunity by binding to peptidoglycans (PGN) of bacteria and activating the immune response., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4V1I9", "ec_number_list": [], "go_molecular_function": "GO:0042834 peptidoglycan binding;GO:0008270 zinc ion binding;GO:0016019 peptidoglycan immune receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0045087 innate immune response;GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9GN97-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NNF2-1", "uniprot_id": [ { "id": "PDE8_DROME", "url": "https://www.uniprot.org/uniprot/Q6NNF2", "type": "external" } ], "mass": 102052.0, "length": 914, "protein_name": "High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8", "gene_name": "Pde8", "organism": "Fruit fly", "refseq_name": "phosphodiesterase 8, isoform I", "refseq_ac": [ { "id": "NP_001163274", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163274", "type": "external" } ], "gene_names_uniprotkb": "Pde8; CG42241; CG45019; CG5411; Dmel\\CG45019; Dmel_CG45019; PDE8; pde8", "gene_names_refseq": "CG42241; CG45019; CG5411; Dmel\\CG45019; PDE8; Pde8; pde8", "protein_names_uniprotkb": "High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8; 3.1.4.53; Phosphodiesterase 8", "protein_names_refseq": "CG45019-PI; Pde8-PI; phosphodiesterase 8, isoform I", "tax_id": 7227, "disease": "primary pigmented nodular adrenocortical disease 3 (Disease Ontology:DOID:0070548)", "pathway": " (dme:Dmel_CG45019); (R-DME-418555)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15673286;16110336;17569856;17569867;23509299;25589440;26109356;26109357", "class_list": "", "function": "Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Involved in the positive regulation of MAP kinase signaling and in inhibiting oxidative stress-induced cell death (PubMed:23509299)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E1JGU3;Q5BI98;Q8MLR0;Q95T53;Q9W1L9", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "", "go_biological_process": "GO:0046058 cAMP metabolic process;GO:0007165 signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0006355 regulation of DNA-templated transcription;GO:0007498 mesoderm development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q6NNF2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48809-1", "uniprot_id": [ { "id": "RB27C_DROME", "url": "https://www.uniprot.org/uniprot/P48809", "type": "external" } ], "mass": 44770.0, "length": 421, "protein_name": "Heterogeneous nuclear ribonucleoprotein 27C", "gene_name": "Hrb27C", "organism": "Fruit fly", "refseq_name": "heterogeneous nuclear ribonucleoprotein at 27C, isoform D", "refseq_ac": [ { "id": "NP_001162897", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162897", "type": "external" } ], "gene_names_uniprotkb": "Hrb27C; 10280; CG10377; Dmel\\CG10377; Dmel_CG10377; HRB27C; HRP48; Hrb27-C; Hrb27C; Hrb27c; Hrb48; Hrp48; Ov5; RRM7; Rbp7; hnRNP-C; hnRNP27C; hnRNP48; hrb27C; hrb27c; hrb27; hrp48; l(2)02647; l(2)10280; l(2)2647; linha; p50; rrm7", "gene_names_refseq": "10280; CG10377; Dmel\\CG10377; HRB27C; HRP48; Hrb27-C; Hrb27C/Hrp48; Hrb27C; Hrb27c; Hrb48; Hrp48/Hrb27C; Hrp48; Ov5; RRM7; Rbp7; hnRNP-C; hnRNP27C; hnRNP48; hrb27C; hrb27c; hrb27; hrp48; l(2)02647; l(2)10280; l(2)2647; linha; p50; rrm7", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein 27C; HRP48.1; Hrb27-C; hnRNP 48", "protein_names_refseq": "CG10377-PD; Hrb27C-PD; RNA-binding protein 7; heterogeneous nuclear ribonucleoprotein at 27C, isoform D; heterogeneous nuclear ribonucleoprotein; linha", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10377)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15056611;15917496;16110336;1730754;17569856;17569867;18327897;25589440;26109356;26109357;8417324;9372958", "class_list": "", "function": "This protein is a component of ribonucleosomes. Could be needed to organize a concentration gradient of a dorsalizing morphogen (Dm) originating in the germinal vesicle. Interacts with grk mRNA (via 3' UTR) and involved in its localization to the dorsal anterior region of the oocyte during dorsal-ventral axis determination; may function as a ribonuclear protein complex together with sqd and otu (PubMed:15056611). Required for polytene chromosome dispersal in nurse cells during oogenesis (PubMed:15056611). May be involved in the regulation of splicing (PubMed:9372958)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4V0B8;Q7JPT5;Q9TY67;Q9VM68", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0030371 translation repressor activity;GO:0003730 mRNA 3'-UTR binding;GO:0003697 single-stranded DNA binding;GO:0048027 mRNA 5'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0007283 spermatogenesis;GO:0045727 positive regulation of translation;GO:0048024 regulation of mRNA splicing, via spliceosome;GO:0007319 negative regulation of oskar mRNA translation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P48809-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V3L1-1", "uniprot_id": [ { "id": "NDST_DROME", "url": "https://www.uniprot.org/uniprot/Q9V3L1", "type": "external" } ], "mass": 118590.0, "length": 1048, "protein_name": "Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase", "gene_name": "sfl", "organism": "Fruit fly", "refseq_name": "sulfateless, isoform B", "refseq_ac": [ { "id": "NP_001163354", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163354", "type": "external" } ], "gene_names_uniprotkb": "sfl; CG8339; CT24567; Dmel\\CG8339; Dmel_CG8339; NDST; Ndst; SFL; Sfl; dw; l(3)03844; lincRNA.S4253", "gene_names_refseq": "CG8339; CT24567; Dmel\\CG8339; NDST; Ndst; SFL; Sfl; dw; l(3)03844; lincRNA.S4253; sfl", "protein_names_uniprotkb": "Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase; 2.8.2.8; Glucosaminyl N-deacetylase/N-sulfotransferase; Sulfateless", "protein_names_refseq": "CG8339-PB; HS N-deacetylase/N-sulfotransferase; diet-wingless; sfl-PB; sulfateless, isoform B; sulfateless", "tax_id": 7227, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal recessive intellectual developmental disorder 46 (Disease Ontology:DOID:0081210); intellectual disability (Disease Ontology:DOID:1059); DiGeorge syndrome (Disease Ontology:DOID:11198); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); azoospermia (Disease Ontology:DOID:14227); germ cell cancer (Disease Ontology:DOID:2994); congenital diaphragmatic hernia (Disease Ontology:DOID:3827)", "pathway": " (dme:Dmel_CG8339); (R-DME-2022928)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10421372;10433902;10644674;10731132;12537568;12537572;12537573;12537574;15531366;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in diffusion of morphogen wingless (wg) via its role in heparan sulfate proteoglycans (HSPGs) biosynthesis, HSPGs being required for movement of wg morphogens. Required for wg signaling during both embryonic and imaginal disk development. Also required for FGF receptor signaling., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" }, { "id": "3.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.-.-.-", "type": "external" }, { "id": "2.8.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.8", "type": "external" } ], "go_molecular_function": "GO:0019213 deacetylase activity;GO:0015016 heparan sulfate N-sulfotransferase activity;GO:0102140 heparan sulfate N-deacetylase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0000137 Golgi cis cisterna", "go_biological_process": "GO:0007283 spermatogenesis;GO:0016055 Wnt signaling pathway;GO:0006024 glycosaminoglycan biosynthetic process;GO:0030210 heparin proteoglycan biosynthetic process;GO:0006790 sulfur compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9V3L1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8MSX2-1", "uniprot_id": [ { "id": "MED6_DROME", "url": "https://www.uniprot.org/uniprot/Q8MSX2", "type": "external" } ], "mass": 28374.0, "length": 249, "protein_name": "Mediator of RNA polymerase II transcription subunit 6", "gene_name": "MED6", "organism": "Fruit fly", "refseq_name": "mediator complex subunit 6, isoform C", "refseq_ac": [ { "id": "NP_001163577", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163577", "type": "external" } ], "gene_names_uniprotkb": "MED6; BcDNA:LD15729; CG9473; Dmel\\CG9473; Dmel_CG9473; Med6; Trap32; anon-EST:Posey279; dMED6; dMed6; dTRAP32; med6; p35", "gene_names_refseq": "BcDNA:LD15729; CG9473; Dmel\\CG9473; MED6; Med6; Trap32; anon-EST:Posey279; dMED6; dMed6; dTRAP32; med6; p35", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 6; Mediator complex subunit 6; dMED6", "protein_names_refseq": "CG9473-PC; MED6-PC; mediator complex subunit 6, isoform C; mediator", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9473); (R-DME-9841922)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10731132;11259581;11511356;12021283;12537568;12537569;12537572;12537573;12537574;16110336;16751183;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VH74", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0050829 defense response to Gram-negative bacterium;GO:0045893 positive regulation of DNA-templated transcription;GO:0045824 negative regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8MSX2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0KI85-1", "uniprot_id": [ { "id": "Q0KI85_DROME", "url": "https://www.uniprot.org/uniprot/Q0KI85", "type": "external" } ], "mass": 118797.0, "length": 1087, "protein_name": "Sidestep VI, isoform B", "gene_name": "side-VI", "organism": "Fruit fly", "refseq_name": "sidestep VI, isoform B", "refseq_ac": [ { "id": "NP_001036705", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036705", "type": "external" } ], "gene_names_uniprotkb": "side-VI; 34114; CG14698; CG34114; CG4695; Dmel\\CG34114; Dmel_CG34114", "gene_names_refseq": "34114; CG14698; CG34114; CG4695; Dmel\\CG34114; side-VI", "protein_names_uniprotkb": "Sidestep VI, isoform B", "protein_names_refseq": "CG34114-PB; side-VI-PB; sidestep VI, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG34114)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q0KI85-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.1000000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48810-1", "uniprot_id": [ { "id": "RB87F_DROME", "url": "https://www.uniprot.org/uniprot/P48810", "type": "external" } ], "mass": 39499.0, "length": 385, "protein_name": "Heterogeneous nuclear ribonucleoprotein 87F", "gene_name": "Hrb87F", "organism": "Fruit fly", "refseq_name": "heterogeneous nuclear ribonucleoprotein at 87F, isoform C", "refseq_ac": [ { "id": "NP_001163602", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163602", "type": "external" } ], "gene_names_uniprotkb": "Hrb87F; A2; B1; CG12749; Dmel\\CG12749; Dmel_CG12749; HRB87F; HRP36; Hrb2; Hrb85CD; Hrb87Fa; Hrb87F; Hrb87f; Hrp36; P11; Q14; Q16; hnRNP36; hnRNPA1; hnRNPA2; hrb87f; hrp36; p38", "gene_names_refseq": "CG12749; Dmel\\CG12749; HRB87F/hrp36; HRB87F; HRP36; Hrb2; Hrb85CD; Hrb87Fa; Hrb87F; Hrb87f; Hrp36; P11/Hrb87F; P11; Q14; Q16; hnRNP A2/B1; hnRNP36; hnRNPA1/A2; hnRNPA1; hnRNPA2/B1; hnRNPA2; hrb87f; hrp36; p38", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein 87F; HRP36.1 protein; Protein P11", "protein_names_refseq": "CG12749-PC; Hrb87F-PC; heterogeneous nuclear ribonucleoprotein at 85CD; heterogeneous nuclear ribonucleoprotein at 87F, isoform C; hnRNA-binding protein 2", "tax_id": 7227, "disease": "inclusion body myopathy with Paget disease of bone and frontotemporal dementia (Disease Ontology:DOID:0050881); amyotrophic lateral sclerosis type 20 (Disease Ontology:DOID:0060211); distal myopathy 3 (Disease Ontology:DOID:0111189); inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 2 (Disease Ontology:DOID:0111384); inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3 (Disease Ontology:DOID:0111386); silicosis (Disease Ontology:DOID:10325); Alzheimer's disease (Disease Ontology:DOID:10652); transient cerebral ischemia (Disease Ontology:DOID:224); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); lung non-small cell carcinoma (Disease Ontology:DOID:3908); pancreatic carcinoma (Disease Ontology:DOID:4905); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (dme:Dmel_CG12749)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;1717937;1730754;17569856;17569867;1849257;25589440;26109356;26109357", "class_list": "", "function": "This protein is a component of ribonucleosomes. Could be needed to organize a concentration gradient of a dorsalizing morphogen (Dm) originating in the germinal vesicle., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24486;Q8INH0;Q9VFT2", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0043565 sequence-specific DNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0034046 poly(G) binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0000785 chromatin;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0000278 mitotic cell cycle;GO:0042594 response to starvation;GO:0008585 female gonad development;GO:0009408 response to heat", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P48810-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VCZ8-1", "uniprot_id": [ { "id": "PFD5_DROME", "url": "https://www.uniprot.org/uniprot/Q9VCZ8", "type": "external" } ], "mass": 19078.0, "length": 168, "protein_name": "Probable prefoldin subunit 5", "gene_name": "Pfdn5", "organism": "Fruit fly", "refseq_name": "prefoldin 5, isoform B", "refseq_ac": [ { "id": "NP_001163688", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163688", "type": "external" } ], "gene_names_uniprotkb": "Pfdn5; CG7048; Dmel\\CG7048; Dmel_CG7048; pfdn5", "gene_names_refseq": "CG7048; Dmel\\CG7048; Pfdn5; pfdn5", "protein_names_uniprotkb": "Probable prefoldin subunit 5", "protein_names_refseq": "CG7048-PB; Pfdn5-PB; prefoldin 5, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7048)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;40245499", "class_list": "", "function": "Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016272 prefoldin complex", "go_biological_process": "GO:0006457 protein folding;GO:1990114 RNA polymerase II core complex assembly;GO:1990113 RNA polymerase I assembly;GO:1990115 RNA polymerase III assembly", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9VCZ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VCZ3-1", "uniprot_id": [ { "id": "OCTB1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VCZ3", "type": "external" } ], "mass": 56855.0, "length": 508, "protein_name": "Octopamine receptor beta-1R", "gene_name": "Octbeta1R", "organism": "Fruit fly", "refseq_name": "octopamine beta1 receptor, isoform B", "refseq_ac": [ { "id": "NP_001034064", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034064", "type": "external" } ], "gene_names_uniprotkb": "Octbeta1R; CG6919; DmCG6919; DmOctBeta1R; DmOctbeta1R; Dmel\\CG6919; Dmel_CG6919; Dmoa2; OA2; Oa2; Oct-beta-1; OctBeta1; anon-WO0170980.67; anon-WO0170980.68; oa2; octbeta1R; octbeta1r", "gene_names_refseq": "CG6919; DmCG6919; DmOctBeta1R; DmOctbeta1R; Dmel\\CG6919; Dmoa2; OA2; Oa2; OctBeta1; Octbeta1R; anon-WO0170980.67; anon-WO0170980.68; oa2; octbeta1R; octbeta1r", "protein_names_uniprotkb": "Octopamine receptor beta-1R; DmOA2; DmOct-beta-1R", "protein_names_refseq": "CG6919-PB; Octbeta1R-PB; octopamine beta1 receptor, isoform B; octopamine receptor 2; octopamine receptor", "tax_id": 7227, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); gout (Disease Ontology:DOID:13189); endometrial cancer (Disease Ontology:DOID:1380); cystic fibrosis (Disease Ontology:DOID:1485); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); anorexia nervosa (Disease Ontology:DOID:8689); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG6919); (R-DME-390651); (R-DME-390696); (R-DME-418555); (R-DME-5689880); (R-DME-8856825); (R-DME-8856828)", "pathway_count": 7, "publication_count": 15, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;15816867;15998303;16110336;17569856;17569867;22303848;22553037;25589440;26109356;26109357", "class_list": "", "function": "Autoreceptor for octopamine, which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates (PubMed:15816867, PubMed:22553037). Negatively regulates synaptic growth by activating the inhibitory G protein Galphao and limiting cAMP production (PubMed:22553037). Antagonizes the action of Octbeta2R which stimulates synaptic growth (PubMed:22553037)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4KHN2;Q2PDQ3;Q4LBC0", "ec_number_list": [], "go_molecular_function": "GO:0004935 adrenergic receptor activity;GO:0004989 octopamine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0043410 positive regulation of MAPK cascade;GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0045886 negative regulation of synaptic assembly at neuromuscular junction", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9VCZ3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NN85-1", "uniprot_id": [ { "id": "SSH_DROME", "url": "https://www.uniprot.org/uniprot/Q6NN85", "type": "external" } ], "mass": 114997.0, "length": 1045, "protein_name": "Protein phosphatase Slingshot", "gene_name": "ssh", "organism": "Fruit fly", "refseq_name": "slingshot, isoform C", "refseq_ac": [ { "id": "NP_001163716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163716", "type": "external" } ], "gene_names_uniprotkb": "ssh; CG6238; Dmel\\CG6238; Dmel_CG6238; MKP; Mkph; SSH; Ssh; l(3)01207", "gene_names_refseq": "CG6238; Dmel\\CG6238; MKP; Mkph; SSH; Ssh; l(3)01207; ssh", "protein_names_uniprotkb": "Protein phosphatase Slingshot; 3.1.3.16; 3.1.3.48", "protein_names_refseq": "CG6238-PC; MAP-kinase-phosphatase; MKP-like; slingshot, isoform C; slingshot; ssh-PC", "tax_id": 7227, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (dme:Dmel_CG6238)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;11832213;12537568;12537572;12537573;12537574;15572110;16110336;16169194;17569856;17569867;18327897;25411210;25589440;26109356;26109357", "class_list": "", "function": "Protein phosphatase which regulates actin filament dynamics (PubMed:11832213, PubMed:16169194). Dephosphorylates and activates the actin binding/depolymerizing factor tsr/cofilin, which subsequently binds to actin filaments and stimulates their disassembly (PubMed:11832213, PubMed:25411210). Required for axon growth (PubMed:15572110)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7KS05;Q8IMU8;Q9NKY1;Q9VC04", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0045177 apical part of cell", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0008064 regulation of actin polymerization or depolymerization;GO:0048749 compound eye development;GO:0000278 mitotic cell cycle;GO:0007409 axonogenesis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q6NN85-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V427-1", "uniprot_id": [ { "id": "INX2_DROME", "url": "https://www.uniprot.org/uniprot/Q9V427", "type": "external" } ], "mass": 42488.0, "length": 367, "protein_name": "Innexin inx2", "gene_name": "Inx2", "organism": "Fruit fly", "refseq_name": "innexin 2, isoform C", "refseq_ac": [ { "id": "NP_001162684", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162684", "type": "external" } ], "gene_names_uniprotkb": "Inx2; CG4590; D-inx-2; Dm-Inx2; Dm-inx2; Dm-inx; Dmel\\CG4590; Dmel_CG4590; FBpp0291074; INX-2; Inx-2; Ix2; inx-2; inx2; inx; kropf; l(1)G0035; l(1)G0036; l(1)G0043; l(1)G0059; l(1)G0118; l(1)G0157; l(1)G0317; l(1)G0364; prp33", "gene_names_refseq": "CG4590; D-inx-2; Dm-Inx2; Dm-inx2; Dm-inx; Dmel\\CG4590; FBpp0291074; INX-2; Inx-2; Inx2; Ix2; inx-2; inx2; kropf; l(1)G0035; l(1)G0036; l(1)G0043; l(1)G0059; l(1)G0118; l(1)G0157; l(1)G0317; l(1)G0364; prp33", "protein_names_uniprotkb": "Innexin inx2; Gap junction protein prp33; Innexin-2; Pas-related protein 33", "protein_names_refseq": "CG4590-PC; Innexin-2; Inx2-PC; innexin 2, isoform C; innexin 2; innexin2; pas related protein 33", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4590)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10352230;10731132;10888681;11956317;11960713;12537568;12537569;12537572;12537573;12537574;15047872;16110336;16436513;17569856;17569867;19038051;22001874;25589440;26109356;26109357", "class_list": "", "function": "Structural component of the gap junctions., [UniProtKB, UniProtKB]; Structural components of the gap junctions. Involved in gap junctional communication between germline and somatic cells which is essential for normal oogenesis. In embryonic epidermis, required for epithelial morphogenesis. Required for keyhole formation during early stages of proventriculus development in response to wg signaling. In follicle cells, promotes the formation of egg chambers in part through regulation of shg and baz at the boundary between germ cells and follicle cells. In inner germarial sheath cells, required for survival of early germ cells and for cyst formation., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V431", "ec_number_list": [], "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0034220 monoatomic ion transmembrane transport;GO:0016331 morphogenesis of embryonic epithelium;GO:0007154 cell communication;GO:0007602 phototransduction", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9V427-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9U969-1", "uniprot_id": [ { "id": "SWS_DROME", "url": "https://www.uniprot.org/uniprot/Q9U969", "type": "external" } ], "mass": 160573.0, "length": 1425, "protein_name": "Neuropathy target esterase sws", "gene_name": "sws", "organism": "Fruit fly", "refseq_name": "swiss cheese, isoform A", "refseq_ac": [ { "id": "NP_511075", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_511075", "type": "external" } ], "gene_names_uniprotkb": "sws; CG2212; Dmel\\CG2212; Dmel_CG2212; PNPLA6; SWS; Sws; olfE", "gene_names_refseq": "CG2212; Dmel\\CG2212; PNPLA6; SWS; Sws; olfE; sws", "protein_names_uniprotkb": "Neuropathy target esterase sws; 3.1.1.5; DSWS; Swiss cheese", "protein_names_refseq": "CG2212-PA; olfactory E; olfactory-E; swiss cheese, isoform A; swiss cheese; swiss-cheese; swisscheese; sws-PA", "tax_id": 7227, "disease": "cerebellar ataxia (Disease Ontology:DOID:0050753); hereditary spastic paraplegia 39 (Disease Ontology:DOID:0110790); Boucher-Neuhauser syndrome (Disease Ontology:DOID:0111265); Oliver-McFarlane syndrome (Disease Ontology:DOID:0111271); neurodegenerative disease (Disease Ontology:DOID:1289); blindness (Disease Ontology:DOID:1432); Laurence-Moon syndrome (Disease Ontology:DOID:1930); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (dme:Dmel_CG2212); (R-DME-6814848)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15772346;16110336;17569856;17569867;18327897;18945896;25589440;26109356;26109357;9295388", "class_list": "", "function": "Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8E6M7;Q8IRN7;Q95RE9;Q9W3M0", "ec_number_list": [ { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" } ], "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0102545 phospholipase B activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0051402 neuron apoptotic process;GO:0016042 lipid catabolic process;GO:0061024 membrane organization;GO:0045494 photoreceptor cell maintenance;GO:0046470 phosphatidylcholine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9U969-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24568-1", "uniprot_id": [ { "id": "NETB_DROME", "url": "https://www.uniprot.org/uniprot/Q24568", "type": "external" } ], "mass": 87134.0, "length": 793, "protein_name": "Netrin-B", "gene_name": "NetB", "organism": "Fruit fly", "refseq_name": "Netrin-B, isoform B", "refseq_ac": [ { "id": "NP_001162753", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162753", "type": "external" } ], "gene_names_uniprotkb": "NetB; CG10521; CG15021; CT29512; Dmel\\CG10521; Dmel_CG10521; NETB; NetrinB; netB; netrin B; netrin; net", "gene_names_refseq": "CG10521; CG15021; CT29512; Dmel\\CG10521; NETB; NetB; NetrinB; netB; netrin B; netrin; net", "protein_names_uniprotkb": "Netrin-B", "protein_names_refseq": "CG10521-PB; D-netrin-B; D-netrin; NetB-PB; Netrin-B, isoform B; netrin B; netrinB", "tax_id": 7227, "disease": "mirror movements 4 (Disease Ontology:DOID:0070638)", "pathway": " (dme:Dmel_CG10521)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;11719202;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8780645;8780646", "class_list": "", "function": "Netrins control guidance of CNS commissural axons and peripheral motor axons (PubMed:11719202, PubMed:8780645, PubMed:8780646). Its association with either fra or unc-5 receptors will lead to axon attraction or repulsion, respectively (PubMed:11719202). While short-range repulsion requires both fra and unc-5 receptors, long-range repulsion only requires unc-5 (PubMed:11719202)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9VY23", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0043025 neuronal cell body;GO:0048471 perinuclear region of cytoplasm;GO:0005604 basement membrane;GO:0044295 axonal growth cone", "go_biological_process": "GO:0048749 compound eye development;GO:0016358 dendrite development;GO:0009887 animal organ morphogenesis;GO:0007411 axon guidance;GO:0009888 tissue development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q24568-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7K1V5-1", "uniprot_id": [ { "id": "JAGN_DROME", "url": "https://www.uniprot.org/uniprot/Q7K1V5", "type": "external" } ], "mass": 23036.0, "length": 197, "protein_name": "Protein jagunal", "gene_name": "jagn", "organism": "Fruit fly", "refseq_name": "jagunal, isoform A", "refseq_ac": [ { "id": "NP_649585", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649585", "type": "external" } ], "gene_names_uniprotkb": "jagn; CG10978; Dmel\\CG10978; Dmel_CG10978; Jagn", "gene_names_refseq": "CG10978; Dmel\\CG10978; Jagn; jagn", "protein_names_uniprotkb": "Protein jagunal", "protein_names_refseq": "CG10978-PA; jagn-PA; jagunal, isoform A", "tax_id": 7227, "disease": "severe congenital neutropenia 6 (Disease Ontology:DOID:0112134)", "pathway": " (dme:Dmel_CG10978)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17389229;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Required for endoplasmic reticulum organization and proper vesicular traffic during vitellogenesis. Required for oocyte and bristle growth., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007296 vitellogenesis;GO:0016192 vesicle-mediated transport;GO:0006887 exocytosis;GO:0007029 endoplasmic reticulum organization;GO:0001555 oocyte growth", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q7K1V5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7K4N3-1", "uniprot_id": [ { "id": "NCBP1_DROME", "url": "https://www.uniprot.org/uniprot/Q7K4N3", "type": "external" } ], "mass": 93227.0, "length": 800, "protein_name": "Nuclear cap-binding protein subunit 1", "gene_name": "Cbp80", "organism": "Fruit fly", "refseq_name": "cap binding protein 80, isoform B", "refseq_ac": [ { "id": "NP_524750", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524750", "type": "external" } ], "gene_names_uniprotkb": "Cbp80; CBP80; CG7035; Dmel\\CG7035; Dmel_CG7035; EG:84H4.3; cbp80", "gene_names_refseq": "CBP80; CG7035; Cbp80; Dmel\\CG7035; EG:84H4.3; cbp80", "protein_names_uniprotkb": "Nuclear cap-binding protein subunit 1; 80 kDa nuclear cap-binding protein; CBP80; NCBP 80 kDa subunit", "protein_names_refseq": "CG7035-PB; Cap binding protein 80; Cap-binding protein 80; Cbp80-PB; cap binding protein 80, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7035); (R-DME-111367); (R-DME-113418); (R-DME-159227); (R-DME-159230); (R-DME-159231); (R-DME-159236); (R-DME-674695); (R-DME-6807505); (R-DME-72086); (R-DME-72163); (R-DME-72165); (R-DME-72203); (R-DME-73856); (R-DME-77588); (R-DME-77595); (R-DME-975956); (R-DME-975957); (R-DME-9770562); (R-DME-9930044)", "pathway_count": 20, "publication_count": 15, "publication_id_list": "10731132;10731137;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;19632183;25589440;26109356;26109357", "class_list": "", "function": "Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing. Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. In the CBC complex, Cbp80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of Cbp20 and lock the CBC into a high affinity cap-binding state with the cap structure., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7K7B2;Q9U980", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0000339 RNA cap binding", "go_cellular_component": "GO:0005634 nucleus;GO:0071013 catalytic step 2 spliceosome;GO:0071011 precatalytic spliceosome;GO:0005846 nuclear cap binding complex;GO:0099523 presynaptic cytosol", "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0045071 negative regulation of viral genome replication;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing;GO:0030422 siRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q7K4N3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06559-1", "uniprot_id": [ { "id": "RS3_DROME", "url": "https://www.uniprot.org/uniprot/Q06559", "type": "external" } ], "mass": 27471.0, "length": 246, "protein_name": "Small ribosomal subunit protein uS3", "gene_name": "RpS3", "organism": "Fruit fly", "refseq_name": "ribosomal protein S3, isoform B", "refseq_ac": [ { "id": "NP_001287481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287481", "type": "external" } ], "gene_names_uniprotkb": "RpS3; 6779; CG6779; DmRpS3; Dmel\\CG6779; Dmel_CG6779; IP15838p; M(3)124; M(3)95A; M(3)B2; M(3)B; M(3)Fla; M(3)w; M(3R)w; M95A; M[[w]]; Mw; M; RPS3; RS3; Rp S3; Rps3; S3; X72921; chr3R:19185518..19185701; dS3; rpS3; rps3", "gene_names_refseq": "6779; CG6779; DmRpS3; Dmel\\CG6779; IP15838p; M(3)124; M(3)95A; M(3)B2; M(3)B; M(3)Fla; M(3)w; M(3R)w; M95A; M[[w]]; Mw; M; RPS3; RS3; Rp S3; RpS3; Rps3; S3; X72921; chr3R:19185518..19185701; dS3; rpS3; rps3", "protein_names_uniprotkb": "Small ribosomal subunit protein uS3; 40S ribosomal protein S3", "protein_names_refseq": "CG6779-PB; Minute(3)95A; RpS3-PB; minute; ribosomal protein S3, isoform B; ribosomal protein S3; rps3 gene", "tax_id": 7227, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)", "pathway": " (dme:Dmel_CG6779); (R-DME-156827); (R-DME-1799339); (R-DME-72649); (R-DME-72689); (R-DME-72695); (R-DME-72702); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 12, "publication_count": 18, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;23636399;25589440;25858587;26109356;26109357;7685082;8070662;8641296", "class_list": "", "function": "Has DNA repair activity directed towards the mutagenic lesions 8-oxoguanine and abasic sites in DNA. It can cleave DNA containing 8-oxoguanine residues efficiently. Also acts as an ap lyase, cleaving phosphodiester bonds via a beta,delta elimination reaction., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VCM9", "ec_number_list": [], "go_molecular_function": "GO:0032357 oxidized purine DNA binding;GO:0003723 RNA binding;GO:0003684 damaged DNA binding;GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0016363 nuclear matrix;GO:0022626 cytosolic ribosome;GO:0022627 cytosolic small ribosomal subunit;GO:0015935 small ribosomal subunit", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006281 DNA repair;GO:2001235 positive regulation of apoptotic signaling pathway;GO:0043524 negative regulation of neuron apoptotic process;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q06559-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IMA8-1", "uniprot_id": [ { "id": "PANG2_DROME", "url": "https://www.uniprot.org/uniprot/Q8IMA8", "type": "external" } ], "mass": 132080.0, "length": 1192, "protein_name": "Protein pangolin, isoform J", "gene_name": "pan", "organism": "Fruit fly", "refseq_name": "pangolin, isoform J", "refseq_ac": [ { "id": "NP_726528", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_726528", "type": "external" } ], "gene_names_uniprotkb": "pan; CG17964; CG32005; CG34403; DTCF; DTcf; Dm Pan; Dmel\\CG34403; Dmel_CG34403; IA5; LEF-1; LEF1; LEF; Lef1; Lef; PAN; Pan; TCF-1; TCF; Tcf-1; Tcf; d-TCF; dTCF; dTcf; l(4)102ABb; l(4)13; lef1; pan.dTCF; tcf", "gene_names_refseq": "CG17964; CG32005; CG34403; DTCF; DTcf; Dm Pan; Dmel\\CG34403; IA5; LEF-1; LEF/TCF-1; LEF/TCF; LEF1/TCF; LEF1; LEF; Lef1; Lef; PAN; Pan; TCF/LEF1; TCF/LEF; TCF/Pan; TCF; Tcf-1; Tcf/LEF; Tcf/Lef; Tcf; d-TCF; dTCF; dTcf; l(4)102ABb; l(4)13; lef1; pan.dTCF; pan; tcf", "protein_names_uniprotkb": "Protein pangolin, isoform J; dTCF", "protein_names_refseq": "CG34403-PJ; T-cell factor; TCF; lethal 13; lymphocyte enhancer binding factor 1/T cell factor; pan-PJ; pangolin, isoform J; pangolin", "tax_id": 7227, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); prostate cancer (Disease Ontology:DOID:10283); gestational diabetes (Disease Ontology:DOID:11714); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); anxiety disorder (Disease Ontology:DOID:2030); ovarian cancer (Disease Ontology:DOID:2394); papillary thyroid carcinoma (Disease Ontology:DOID:3969); prostate carcinoma in situ (Disease Ontology:DOID:8634); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG34403); (R-DME-201722); (R-DME-209421); (R-DME-209441); (R-DME-3769402); (R-DME-4086398); (R-DME-4641265); (R-DME-8853884); (R-DME-8951430); (R-DME-9825892)", "pathway_count": 10, "publication_count": 21, "publication_id_list": "10731132;11955446;12537568;12537572;12537573;12537574;14668375;15043810;15208637;15768032;16110336;16169192;16554443;17569856;17569867;25589440;26109356;26109357;9039917;9118222;9783586", "class_list": "", "function": "Segment polarity protein. Functions together with arm to transduce the Wingless (Wg) signal in embryos and in developing adult tissues. Acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AVW4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0019900 kinase binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0001222 transcription corepressor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0005634 nucleus;GO:0000785 chromatin;GO:1990907 beta-catenin-TCF complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8IMA8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8MR31-1", "uniprot_id": [ { "id": "SLIP1_DROME", "url": "https://www.uniprot.org/uniprot/Q8MR31", "type": "external" } ], "mass": 85846.0, "length": 767, "protein_name": "Slo-interacting protein 1", "gene_name": "Slip1", "organism": "Fruit fly", "refseq_name": "SLo interacting protein 1, isoform A", "refseq_ac": [ { "id": "NP_651933", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651933", "type": "external" } ], "gene_names_uniprotkb": "Slip1; CG1783; Dmel\\CG1783; Dmel_CG1783; dSLIP1", "gene_names_refseq": "CG1783; Dmel\\CG1783; Slip1; dSLIP1", "protein_names_uniprotkb": "Slo-interacting protein 1; dSLIP1", "protein_names_refseq": "CG1783-PA; SLo interacting protein 1, isoform A; Slip1-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1783)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;11778050;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;9502797", "class_list": "", "function": "May selectively reduce calcium-activated potassium channel (Slo) currents by reducing the number of Slo channels in the plasma membrane., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8STH5;Q9V4F2", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8MR31-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9U6A0-1", "uniprot_id": [ { "id": "NCKX_DROME", "url": "https://www.uniprot.org/uniprot/Q9U6A0", "type": "external" } ], "mass": 95129.0, "length": 881, "protein_name": "Sodium/potassium/calcium exchanger Nckx30C", "gene_name": "Nckx30C", "organism": "Fruit fly", "refseq_name": "Nckx30C, isoform E", "refseq_ac": [ { "id": "NP_001188761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001188761", "type": "external" } ], "gene_names_uniprotkb": "Nckx30C; CG18660; CG4106; Dmel\\CG18660; Dmel_CG18660; NcKX30C; NcKx30C; NckX30C; Nckx30c; Nck", "gene_names_refseq": "CG18660; CG4106; Dmel\\CG18660; NcKX30C; NcKx30C; NckX30C; Nckx30C; Nckx30c; Nck; potassium-dependent sodium/calcium", "protein_names_uniprotkb": "Sodium/potassium/calcium exchanger Nckx30C; Na(+)/K(+)/Ca(2+)-exchange protein Nckx30C", "protein_names_refseq": "CG18660-PE; Nckx30C, isoform E; Nckx30C-PE", "tax_id": 7227, "disease": "congenital stationary night blindness 1D (Disease Ontology:DOID:0110868)", "pathway": " (dme:Dmel_CG18660); (R-DME-425561)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10545508;10731132;12537568;12537569;12537572;12537573;12537574;16110336;17018572;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "May function in the removal and maintenance of calcium homeostasis during signaling in the adult and in signaling events during embryogenesis and patterning of imaginal disks. Transports one Ca(2+) and 1 K(+) in exchange for 4 Na(+)., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A4V0I2;C7LAF4;Q8IPE3;Q8SXD2;Q9VL95", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0015293 symporter activity;GO:0008273 calcium, potassium:sodium antiporter activity;GO:0015297 antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0048749 compound eye development;GO:0006816 calcium ion transport;GO:0006874 intracellular calcium ion homeostasis;GO:0070588 calcium ion transmembrane transport;GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9U6A0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9NFP5-1", "uniprot_id": [ { "id": "SH3BG_DROME", "url": "https://www.uniprot.org/uniprot/Q9NFP5", "type": "external" } ], "mass": 17488.0, "length": 158, "protein_name": "SH3 domain-binding glutamic acid-rich protein homolog", "gene_name": "Sh3beta", "organism": "Fruit fly", "refseq_name": "Sh3beta, isoform B", "refseq_ac": [ { "id": "NP_648112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648112", "type": "external" } ], "gene_names_uniprotkb": "Sh3beta; CG8582; Dmel\\CG8582; Dmel_CG8582; LD12912; SH3BGR; SH3beta", "gene_names_refseq": "CG8582; Dmel\\CG8582; LD12912; SH3beta; Sh3beta", "protein_names_uniprotkb": "SH3 domain-binding glutamic acid-rich protein homolog; SH3BGR protein", "protein_names_refseq": "CG8582-PB; Sh3beta, isoform B; Sh3beta-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8582)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17372656;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0E8H4;Q9VS58", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9NFP5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8T498-1", "uniprot_id": [ { "id": "GAP2_DROME", "url": "https://www.uniprot.org/uniprot/Q8T498", "type": "external" } ], "mass": 173530.0, "length": 1580, "protein_name": "Ras GTPase-activating protein raskol", "gene_name": "raskol", "organism": "Fruit fly", "refseq_name": "raskol, isoform C", "refseq_ac": [ { "id": "NP_001097012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097012", "type": "external" } ], "gene_names_uniprotkb": "raskol; CG15816; CG32559; CG32560; CG42270; CG42684; CG5898; CG5960; Dmel\\CG42684; Dmel_CG42684; FBpp0112350", "gene_names_refseq": "CG15816; CG32559; CG32560; CG42270; CG42684; CG5898; CG5960; Dmel\\CG42684; FBpp0112350; raskol", "protein_names_uniprotkb": "Ras GTPase-activating protein raskol", "protein_names_refseq": "CG42684-PC; raskol, isoform C; raskol-PC", "tax_id": 7227, "disease": "peripheral artery disease (Disease Ontology:DOID:0050830); developmental disorder of mental health (Disease Ontology:DOID:0060037); autosomal dominant intellectual developmental disorder 5 (Disease Ontology:DOID:0070035); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); lung cancer (Disease Ontology:DOID:1324); atherosclerosis (Disease Ontology:DOID:1936); coronary artery disease (Disease Ontology:DOID:3393); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); abdominal aortic aneurysm (Disease Ontology:DOID:7693); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); pulmonary embolism (Disease Ontology:DOID:9477)", "pathway": " (dme:Dmel_CG42684); (R-DME-5658442)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;30763317", "class_list": "", "function": "GTPase-activating protein, which acts as a negative regulator for some members of the Ras family (By similarity). Probably decreases their signaling activity by stimulating their intrinsic GTPase activity, thereby lowering the levels of the GTP-bound active form (By similarity). Functions with DE-cadherin (shg) to promote embryonic border cell (BC) migration and adhesion by regulating the distribution of actin protrusions in BCs (PubMed:30763317). Promotes shg-mediated adhesion at the BC interfaces and likely maintains BC cluster adhesion during BC detachment from the follicular epithelium and subsequent BC migration (PubMed:30763317). Also required for restricting the development of actin-rich protrusions to the front of migrating BC clusters thus ensuring unidirectional BC migration (PubMed:30763317). Possibly functions by suppressing Rac1 signaling in non-leading BCs, thus limiting its activity to leading BCs where it initiates localized actin cytoskeleton remodeling to produce the polarized protrusions (PubMed:30763317)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8JV42;Q95TL0;Q9VX23", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0045179 apical cortex;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:1902531 regulation of intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8T498-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q95UN8-1", "uniprot_id": [ { "id": "M3KSL_DROME", "url": "https://www.uniprot.org/uniprot/Q95UN8", "type": "external" } ], "mass": 127573.0, "length": 1148, "protein_name": "Mitogen-activated protein kinase kinase kinase", "gene_name": "slpr", "organism": "Fruit fly", "refseq_name": "slipper, isoform C", "refseq_ac": [ { "id": "NP_001188559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001188559", "type": "external" } ], "gene_names_uniprotkb": "slpr; CG2272; D-MLK; Dmel\\CG2272; Dmel_CG2272; JNKKK; Jnkkk; MLK2; MLK; Mlk2; Mlk; Slpr; dMLK2; dMLK", "gene_names_refseq": "CG2272; D-MLK; Dmel\\CG2272; JNKKK; Jnkkk; MLK2; MLK; Mlk2; Mlk; Slpr; dMLK2; dMLK; slpr", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase; 2.7.11.25; Mixed lineage kinase; Protein slipper; dMLK", "protein_names_refseq": "CG2272-PC; mixed lineage protein kinase 2; slipper, isoform C; slipper; slpr-PC", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2272); (R-DME-3371378); (R-DME-5218900); (R-DME-5357905); (R-DME-5673000); (R-DME-5675482); (R-DME-5689880); (R-DME-5689896); (R-DME-69416); (R-DME-9013424)", "pathway_count": 10, "publication_count": 16, "publication_id_list": "10731132;11825878;12504027;12537568;12537569;12537572;12537573;12537574;12676357;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Activates the JUN N-terminal pathway during dorsal closure., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "M9MS26;Q8MRK7;Q95VF6;Q9W3I3", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "5.6.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.8", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0004709 MAP kinase kinase kinase activity;GO:0004706 JUN kinase kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005938 cell cortex", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0046330 positive regulation of JNK cascade;GO:0007254 JNK cascade;GO:0071361 cellular response to ethanol", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q95UN8-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P91664-1", "uniprot_id": [ { "id": "MAX_DROME", "url": "https://www.uniprot.org/uniprot/P91664", "type": "external" } ], "mass": 18530.0, "length": 161, "protein_name": "Protein max", "gene_name": "Max", "organism": "Fruit fly", "refseq_name": "Max, isoform C", "refseq_ac": [ { "id": "NP_001246833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246833", "type": "external" } ], "gene_names_uniprotkb": "Max; CG9648; Dmel\\CG9648; Dmel_CG9648; MAX; bHLHd9; dMax; dmax; max", "gene_names_refseq": "CG9648; Dmel\\CG9648; MAX; Max; bHLHd9; dMax; dmax; max", "protein_names_uniprotkb": "Protein max; Myc-associated factor X; dMax", "protein_names_refseq": "CG9648-PC; Max, isoform C; Max-PC", "tax_id": 7227, "disease": "pheochromocytoma (Disease Ontology:DOID:0050771); lung small cell carcinoma (Disease Ontology:DOID:5409); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (dme:Dmel_CG9648); (R-DME-8953750)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;40245499;8929412", "class_list": "", "function": "Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q1LZ15;Q8SXE2;Q95S07", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity;GO:0046983 protein dimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P91664-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q23989-1", "uniprot_id": [ { "id": "QUAI_DROME", "url": "https://www.uniprot.org/uniprot/Q23989", "type": "external" } ], "mass": 100960.0, "length": 888, "protein_name": "Villin-like protein quail", "gene_name": "qua", "organism": "Fruit fly", "refseq_name": "quail, isoform A", "refseq_ac": [ { "id": "NP_724060", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_724060", "type": "external" } ], "gene_names_uniprotkb": "qua; CG6433; Dmel\\CG6433; Dmel_CG6433; Qua; anon-WO0140519.71; fs(2)A12", "gene_names_refseq": "CG6433; Dmel\\CG6433; Qua; anon-WO0140519.71; fs(2)A12; qua", "protein_names_uniprotkb": "Villin-like protein quail", "protein_names_refseq": "CG6433-PA; female sterile(2)A12; qua-PA; quail, isoform A; quail; villin", "tax_id": 7227, "disease": "Finnish type amyloidosis (Disease Ontology:DOID:0050637); nephrotic syndrome type 21 (Disease Ontology:DOID:0112267); pre-eclampsia (Disease Ontology:DOID:10591); hypothyroidism (Disease Ontology:DOID:1459); cerebral infarction (Disease Ontology:DOID:3526); myocardial infarction (Disease Ontology:DOID:5844); rheumatic myocarditis (Disease Ontology:DOID:8481); lung disease (Disease Ontology:DOID:850); gas gangrene (Disease Ontology:DOID:9159)", "pathway": " (dme:Dmel_CG6433); (R-DME-264870); (R-DME-6798695)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8044841", "class_list": "", "function": "Required for the formation of cytoplasmic actin filament bundles in nurse cells, possibly by regulating both the polymerization and organization of actin filaments. Mutations in quail result in female sterility due to the disruption of cytoplasmic transport from the nurse cells into the oocyte late in oogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q540V4;Q8INY7;Q9VJC9", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0051015 actin filament binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0051016 barbed-end actin filament capping;GO:0008154 actin polymerization or depolymerization;GO:0051014 actin filament severing;GO:0007300 ovarian nurse cell to oocyte transport;GO:0035317 imaginal disc-derived wing hair organization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q23989-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9NDM2-1", "uniprot_id": [ { "id": "GUTR1_DROME", "url": "https://www.uniprot.org/uniprot/Q9NDM2", "type": "external" } ], "mass": 43844.0, "length": 392, "protein_name": "Protein trapped in endoderm-1", "gene_name": "Tre1", "organism": "Fruit fly", "refseq_name": "trapped in endoderm 1, isoform B", "refseq_ac": [ { "id": "NP_001245534", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245534", "type": "external" } ], "gene_names_uniprotkb": "Tre1; BEST:LD12308; CG 3171; CG3171; Dmel\\CG3171; Dmel_CG3171; LD12308; TRE; Tre-1; Tre; anon-WO0170980.16; anon-WO0170980.17; anon-WO0170981.1; sctt; tre-1; tre1", "gene_names_refseq": "BEST:LD12308; CG 3171; CG3171; Dmel\\CG3171; LD12308; TRE; Tre-1; Tre1; Tre; anon-WO0170980.16; anon-WO0170980.17; anon-WO0170981.1; sctt; tre-1; tre1", "protein_names_uniprotkb": "Protein trapped in endoderm-1", "protein_names_refseq": "CG3171-PB; G protein coupled receptor; Tre1-PB; scattershot; trapped in endoderm 1, isoform B; trapped in endoderm 1; trapped in endoderm-1", "tax_id": 7227, "disease": "idiopathic juvenile osteoporosis (Disease Ontology:DOID:12559); Huntington's disease (Disease Ontology:DOID:12858); acute pancreatitis (Disease Ontology:DOID:2913); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dme:Dmel_CG3171)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;10884225;11566105;12537568;12537569;12537572;12537573;12537574;14691551;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Essential for the first active step of germ cell migration: transepithelial migration of germ cells through the posterior midgut (PMG) epithelium., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q95NV3;Q95NV9;Q9NKZ6;Q9W498", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007281 germ cell development;GO:0035234 ectopic germ cell programmed cell death;GO:0008354 germ cell migration", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9NDM2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VMD6-1", "uniprot_id": [ { "id": "RETM_DROME", "url": "https://www.uniprot.org/uniprot/Q9VMD6", "type": "external" } ], "mass": 75679.0, "length": 659, "protein_name": "Protein real-time", "gene_name": "retm", "organism": "Fruit fly", "refseq_name": "real-time, isoform C", "refseq_ac": [ { "id": "NP_001285672", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285672", "type": "external" } ], "gene_names_uniprotkb": "retm; CG9528; Dmel\\CG9528; Dmel_CG9528", "gene_names_refseq": "CG9528; Dmel\\CG9528; retm", "protein_names_uniprotkb": "Protein real-time", "protein_names_refseq": "CG9528-PC; real-time, isoform C; retm-PC", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9528)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15700158;16110336;17018572;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95U56", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9VMD6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VJ07-1", "uniprot_id": [ { "id": "PHLPP_DROME", "url": "https://www.uniprot.org/uniprot/Q9VJ07", "type": "external" } ], "mass": 107092.0, "length": 954, "protein_name": "Protein phosphatase PHLPP-like protein", "gene_name": "Phlpp", "organism": "Fruit fly", "refseq_name": "PH domain leucine-rich repeat protein phosphatase, isoform B", "refseq_ac": [ { "id": "NP_001260558", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260558", "type": "external" } ], "gene_names_uniprotkb": "Phlpp; CG10493; CT29458; Dmel\\CG10493; Dmel_CG10493; PP2C; dPHLPP", "gene_names_refseq": "CG10493; CT29458; Dmel\\CG10493; PP2C; Phlpp; dPHLPP", "protein_names_uniprotkb": "Protein phosphatase PHLPP-like protein; 3.1.3.16; PH domain leucine-rich repeat protein phosphatase; dPHLPP", "protein_names_refseq": "CG10493-PB; PH domain leucine-rich repeat protein phosphatase, isoform B; Phlpp-PB", "tax_id": 7227, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (dme:Dmel_CG10493)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;15808505;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Protein phosphatase that specifically mediates dephosphorylation of 'Ser-586' of Akt1, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-586' of Akt1 triggers apoptosis and suppression of tumor growth., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0006915 apoptotic process;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VJ07-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VIZ0-1", "uniprot_id": [ { "id": "RPAC2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VIZ0", "type": "external" } ], "mass": 11868.0, "length": 105, "protein_name": "DNA-directed RNA polymerases I and III subunit RPAC2", "gene_name": "Polr1D", "organism": "Fruit fly", "refseq_name": "RNA polymerase I and III subunit D, isoform A", "refseq_ac": [ { "id": "NP_609950", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609950", "type": "external" } ], "gene_names_uniprotkb": "Polr1D; AC19; CG10685; Cg; Dmel\\CG10685; Dmel_CG10685; RPC19; l(2)37Cg", "gene_names_refseq": "AC19; CG10685; Cg; Dmel\\CG10685; Polr1D; RPC19; l(2)37Cg", "protein_names_uniprotkb": "DNA-directed RNA polymerases I and III subunit RPAC2; AC19; DNA-directed RNA polymerase I subunit D; RNA polymerase I and III subunit D; RNA polymerases I and III subunit AC2", "protein_names_refseq": "CG10685-PA; Polr1D-PA; RNA polymerase I and III subunit D, isoform A; lethal (2) 37Cg", "tax_id": 7227, "disease": "Treacher Collins syndrome 2 (Disease Ontology:DOID:0080790); leukodystrophy (Disease Ontology:DOID:10579); Treacher Collins syndrome (Disease Ontology:DOID:2908); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG10685)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0IGY9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046983 protein dimerization activity;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005736 RNA polymerase I complex;GO:0005666 RNA polymerase III complex;GO:0000428 DNA-directed RNA polymerase complex", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0042797 tRNA transcription by RNA polymerase III;GO:0006362 transcription elongation by RNA polymerase I;GO:0006383 transcription by RNA polymerase III;GO:0006386 termination of RNA polymerase III transcription", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VIZ0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VIW3-1", "uniprot_id": [ { "id": "RAGP1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VIW3", "type": "external" } ], "mass": 66070.0, "length": 596, "protein_name": "Ran GTPase-activating protein", "gene_name": "RanGAP", "organism": "Fruit fly", "refseq_name": "Ran GTPase activating protein, isoform B", "refseq_ac": [ { "id": "NP_001260578", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260578", "type": "external" } ], "gene_names_uniprotkb": "RanGAP; CG9999; CT28175; Dmel\\CG9999; Dmel_CG9999; RGP1_DROME; RanGAP1; RanGap1; RanGap; Rangap; Ran; SD; Scl; Sd-RanGAP; Sd-RanGap; Sd; dRanGAP; dmRanGAP; ranGAP; ranGap; rangap", "gene_names_refseq": "CG9999; CT28175; Dmel\\CG9999; RGP1_DROME; RanGAP1; RanGAP; RanGap1; RanGap; Rangap; Ran; SD; Scl; Sd-RanGAP; Sd-RanGap; Sd; dRanGAP; dmRanGAP; ranGAP; ranGap; rangap", "protein_names_uniprotkb": "Ran GTPase-activating protein; Protein segregation distorter; RanGAP", "protein_names_refseq": "CG9999-PB; Ran GTPase activating protein, isoform B; Ran GTPase activating protein; Ran-GTPase activating protein; RanGAP-PB; segregation distorter", "tax_id": 7227, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446)", "pathway": " (dme:Dmel_CG9999); (R-DME-4615885); (R-DME-9615933)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "10073941;10731132;12537568;12537569;12537572;12537573;12537574;14729961;16110336;17032737;17569856;17569867;18327897;25589440;26109356;26109357;31626769", "class_list": "", "function": "GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state (By similarity). Trans-acting factor necessary for meiotic distortion (PubMed:10073941). Distortion is only seen in individuals that carry the RanGAP tandem duplication and express a RanGAP truncated protein. Binding of truncated RanGAP product to the Responder(RSP) locus initiates events that lead to sperm dysfunction (PubMed:10073941). During oogenesis, plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components (PubMed:31626769)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9XZI5", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031965 nuclear membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006913 nucleocytoplasmic transport;GO:0007165 signal transduction;GO:0046822 regulation of nucleocytoplasmic transport;GO:0051168 nuclear export;GO:0006611 protein export from nucleus", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9VIW3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VIQ9-1", "uniprot_id": [ { "id": "NAV_DROME", "url": "https://www.uniprot.org/uniprot/Q9VIQ9", "type": "external" } ], "mass": 234498.0, "length": 2197, "protein_name": "Protein neuron navigator", "gene_name": "Nav", "organism": "Fruit fly", "refseq_name": "sickie, isoform D", "refseq_ac": [ { "id": "NP_001097183", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097183", "type": "external" } ], "gene_names_uniprotkb": "Nav; CG10662; CG13958; CG13959; CG13960; CG13961; CG13964; CG33316; CG34343; CG42589; CG43720; Dm_2L:104545; Dmel\\CG43720; Dmel_CG43720; sickie; sick", "gene_names_refseq": "CG10662; CG13958; CG13959; CG13960; CG13961; CG13964; CG33316; CG34343; CG42589; CG43720; Dm_2L:104545; Dmel\\CG43720; sick", "protein_names_uniprotkb": "Protein neuron navigator; Protein sickie", "protein_names_refseq": "CG43720-PD; sick-PD; sickie, isoform D; sickie", "tax_id": 7227, "disease": "cerebellar hypoplasia (Disease Ontology:DOID:0070338); opiate dependence (Disease Ontology:DOID:2559)", "pathway": " (dme:Dmel_CG43720)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;15221030;16110336;17569856;17569867;25411210;25589440;26109356;26109357;35218524;36095217", "class_list": "", "function": "Involved in the non-canonical rac-cofilin signaling pathway that regulates actin polymerization and F-actin mediated axonal growth; functions upstream of ssh and cofilin (PubMed:25411210). Required for the immune deficiency (IMD) pathway, which mediates responses to Gram-negative bacterial infection; favors activation and nuclear translocation of Rel/Relish (PubMed:15221030). Required for proper mushroom body lobe structure formation in the developing brain (PubMed:25411210). Involved in the activity of dopaminergic neurons (DAn), including the MP1 DAn that innervates the heel of the mushroom body and is involved in active forgetting (PubMed:36095217)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "M9PDS2;Q7KT30;Q7KT31", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0030424 axon", "go_biological_process": "GO:0007015 actin filament organization;GO:0007399 nervous system development;GO:0007409 axonogenesis;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9VIQ9-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P91641-1", "uniprot_id": [ { "id": "MED20_DROME", "url": "https://www.uniprot.org/uniprot/P91641", "type": "external" } ], "mass": 27862.0, "length": 252, "protein_name": "Mediator of RNA polymerase II transcription subunit 20", "gene_name": "MED20", "organism": "Fruit fly", "refseq_name": "mediator complex subunit 20, isoform A", "refseq_ac": [ { "id": "NP_524663", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524663", "type": "external" } ], "gene_names_uniprotkb": "MED20; CG18267; CG18780; Dmel\\CG18780; Dmel_CG18780; Med20; TRFP; Tmr; TrfP; Trfp; dTrap26; dTrfp; l(2)28DE; med20; p29", "gene_names_refseq": "CG18267; CG18780; Dmel\\CG18780; MED20; Med20; Srb2/TRFP; Tmr; TrfP; Trfp; dTrap26; dTrfp; l(2)28DE; med20; p29", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 20; Mediator complex subunit 20; Protein trf-proximal; dMED20; dTrap26; dTrfp", "protein_names_refseq": "CG18780-PA; MED20-PA; Trf-proximal; lethal(2)28DE; mediator complex subunit 20, isoform A; transcription mediator-related", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18780); (R-DME-9841922)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;11259581;12021283;12537568;12537572;12537573;12537574;16110336;16751183;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VLT4", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016592 mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P91641-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01604-1", "uniprot_id": [ { "id": "PGK_DROME", "url": "https://www.uniprot.org/uniprot/Q01604", "type": "external" } ], "mass": 43862.0, "length": 415, "protein_name": "Phosphoglycerate kinase", "gene_name": "Pgk", "organism": "Fruit fly", "refseq_name": "phosphoglycerate kinase, isoform B", "refseq_ac": [ { "id": "NP_001259956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259956", "type": "external" } ], "gene_names_uniprotkb": "Pgk; 169C9S; CG3127; Dmel\\CG3127; Dmel_CG3127; ESTS:169C9S; PGK; anon-sts18; l(2)23AB3; l(2)23Ac; pgk1; pgk", "gene_names_refseq": "169C9S; CG3127; Dmel\\CG3127; ESTS:169C9S; PGK; Pgk; anon-sts18; l(2)23AB3; l(2)23Ac; pgk1; pgk", "protein_names_uniprotkb": "Phosphoglycerate kinase; 2.7.2.3", "protein_names_refseq": "CG3127-PB; Pgk-PB; lethal (2) 23AB3; phosphoglycerate kinase, isoform B; phosphoglycerate kinase; phosphoglycerokinase", "tax_id": 7227, "disease": "phosphoglycerate kinase 1 deficiency (Disease Ontology:DOID:0111933); Parkinson's disease (Disease Ontology:DOID:14330); cancer (Disease Ontology:DOID:162); hemolytic anemia (Disease Ontology:DOID:583)", "pathway": " (dme:Dmel_CG3127); (R-DME-165159); (R-DME-70171); (R-DME-70263)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;1465095;16110336;17379620;17569856;17569867;25589440;26109356;26109357;26235423", "class_list": "", "function": "Enzyme of the glycolytic pathway (Probable). Glycolysis is essential in glial cells but not in neurons; neurons rely on the citric acid cycle for their energy needs, and on lactate and alanine secreted into the hemolymph by glial cells to fuel it (PubMed:26235423)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5XCG6;Q3KN29;Q9VQF6", "ec_number_list": [ { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" } ], "go_molecular_function": "GO:0004618 phosphoglycerate kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0043531 ADP binding", "go_cellular_component": "GO:0005829 cytosol;GO:0045202 synapse;GO:0030018 Z disc;GO:0031430 M band;GO:0005737 cytoplasm", "go_biological_process": "GO:0046716 muscle cell cellular homeostasis;GO:0007268 chemical synaptic transmission;GO:0006094 gluconeogenesis;GO:0006096 glycolytic process;GO:0061621 canonical glycolysis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q01604-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VKY8-1", "uniprot_id": [ { "id": "SPS2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VKY8", "type": "external" } ], "mass": 41131.0, "length": 370, "protein_name": "Selenide, water dikinase 2", "gene_name": "Sps2", "organism": "Fruit fly", "refseq_name": "selenophosphate synthetase 2, isoform C", "refseq_ac": [ { "id": "NP_001260329", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260329", "type": "external" } ], "gene_names_uniprotkb": "Sps2; CG5025; Dmel\\CG5025; Dmel_CG5025; Dsps2; SPS2; dSPS2; dsps2; sps2", "gene_names_refseq": "CG5025; Dmel\\CG5025; Dsps2; SPS2; Sps2; dSPS2; dsps2; sps2", "protein_names_uniprotkb": "Selenide, water dikinase 2; 2.7.9.3; Dsps2; Selenium donor protein 2; Selenophosphate synthase 2", "protein_names_refseq": "CG5025-PC; Sps2-PC; selenophosphate synthetase 2, isoform C; selenophosphate synthetase 2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5025); (R-DME-2408557)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;10908323;11258485;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Synthesizes selenophosphate from selenide and ATP., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IPC0;Q9NAX3;Q9NFK7", "ec_number_list": [ { "id": "2.7.9.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.9.3", "type": "external" } ], "go_molecular_function": "GO:0004756 selenide, water dikinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0017076 purine nucleotide binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0016260 selenocysteine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VKY8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27324-1", "uniprot_id": [ { "id": "RYK1_DROME", "url": "https://www.uniprot.org/uniprot/Q27324", "type": "external" } ], "mass": 68312.0, "length": 610, "protein_name": "Inactive tyrosine-protein kinase Drl", "gene_name": "drl", "organism": "Fruit fly", "refseq_name": "derailed, isoform A", "refseq_ac": [ { "id": "NP_477139", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477139", "type": "external" } ], "gene_names_uniprotkb": "drl; CG10758; CG17348; DRL; Dmel\\CG17348; Dmel_CG17348; Drl; drl; lin; lio", "gene_names_refseq": "CG10758; CG17348; DRL; Dmel\\CG17348; Drl; drl; lin; lio/drl; lio", "protein_names_uniprotkb": "Inactive tyrosine-protein kinase Drl; Protein derailed; Protein linotte", "protein_names_refseq": "CG17348-PA; derailed, isoform A; derailed; drl-PA; linotte; lionette", "tax_id": 7227, "disease": "intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (dme:Dmel_CG17348)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10359803;10731132;11135307;11150355;12537568;12537569;12537572;12537573;12537574;12660735;16110336;17569856;17569867;25589440;26109356;26109357;7603568;7656987;8787750", "class_list": "", "function": "Probable coreceptor of specific Wnt proteins, including Wnt5 (PubMed:12660735, PubMed:7603568, PubMed:7656987). Likely to be an inactive receptor tyrosine kinase (Probable). Involved in neuronal pathway recognition and ventral muscle attachment site selection; these functions do not require kinase activity (PubMed:11150355, PubMed:7603568, PubMed:8787750). Receptor required for Wnt5 mediated repulsion of axon projection from the anterior commissure across the midline into the posterior commissure (PubMed:12660735). Non-vital for development (PubMed:7656987). May be part of a signal transduction cascade involved in learning and possibly memory (PubMed:7656987)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9U9Y3;Q9VIY6", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0046982 protein heterodimerization activity;GO:0016740 transferase activity;GO:0017147 Wnt-protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043235 receptor complex", "go_biological_process": "GO:0007165 signal transduction;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007409 axonogenesis;GO:0007611 learning or memory;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q27324-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9U3V5-1", "uniprot_id": [ { "id": "TIPT_DROME", "url": "https://www.uniprot.org/uniprot/Q9U3V5", "type": "external" } ], "mass": 108364.0, "length": 1024, "protein_name": "Protein tiptop", "gene_name": "tio", "organism": "Fruit fly", "refseq_name": "tiptop, isoform B", "refseq_ac": [ { "id": "NP_001260679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260679", "type": "external" } ], "gene_names_uniprotkb": "tio; CG12630; Dmel\\CG12630; Dmel_CG12630; Tio", "gene_names_refseq": "CG12630; Dmel\\CG12630; Tio; tio", "protein_names_uniprotkb": "Protein tiptop", "protein_names_refseq": "CG12630-PB; tio-PB; tiptop, isoform B; tiptop", "tax_id": 7227, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (dme:Dmel_CG12630)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15936749;16110336;17569856;17569867;25589440;26109356;26109357;40245499", "class_list": "", "function": "Tiptop (tio) and teashirt (tsh) have, on the whole, common activities. Tio and tsh repress each other's expression and tsh has a crucial role for trunk patterning that is in part masked by ectopic expression of tiptop. Both genes share a common activity required for the activation of Ser and svb and the maintenance of en and wg., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q95SG6;Q9V9P4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0048749 compound eye development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0048730 epidermis morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9U3V5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VIV2-1", "uniprot_id": [ { "id": "SWM_DROME", "url": "https://www.uniprot.org/uniprot/Q9VIV2", "type": "external" } ], "mass": 115717.0, "length": 1062, "protein_name": "Zinc finger protein swm", "gene_name": "swm", "organism": "Fruit fly", "refseq_name": "second mitotic wave missing, isoform A", "refseq_ac": [ { "id": "NP_609976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609976", "type": "external" } ], "gene_names_uniprotkb": "swm; CG10084; Dmel\\CG10084; Dmel_CG10084; E1; EC2-10; S(Rux)2B; S(rux)2B; Swm1; Swm; l(2)37Dh; l(2)E1", "gene_names_refseq": "CG10084; Dmel\\CG10084; E1; EC2-10; S(Rux)2B; S(rux)2B; Swm1; Swm; l(2)37Dh; l(2)E1; swm", "protein_names_uniprotkb": "Zinc finger protein swm; Protein second mitotic wave missing", "protein_names_refseq": "CG10084-PA; lethal (2) 37Dh; second mitotic wave missing, isoform A; swm-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10084); (R-DME-9930044)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18245841;21203496;25589440;26109356;26109357;40245499", "class_list": "", "function": "Negatively regulates Hedgehog (hh) protein signal in wing development (PubMed:18245841). Regulates neural-specific glycosylation by binding to FucTA mRNA and facilitating its nuclear export in neural cells (PubMed:21203496)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B1NLF3;B1NLF4", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0046833 positive regulation of RNA export from nucleus;GO:0010628 positive regulation of gene expression;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9VIV2-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000100000000000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00963-1", "uniprot_id": [ { "id": "SPTCB_DROME", "url": "https://www.uniprot.org/uniprot/Q00963", "type": "external" } ], "mass": 265739.0, "length": 2291, "protein_name": "Spectrin beta chain", "gene_name": "beta-Spec", "organism": "Fruit fly", "refseq_name": "beta spectrin, isoform A", "refseq_ac": [ { "id": "NP_523388", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523388", "type": "external" } ], "gene_names_uniprotkb": "beta-Spec; B-spec; CG5870; Dmel\\CG5870; Dmel_CG5870; SPEC8; Spec-beta; Spec-b; Specbeta; Spectrin; Spec; anon-EST:fe1B3; b spectrin; b-Spec; beta-spectrin; beta-spec; betaHeavy-Spec; betaSpec; betaspec; beta; i168; i6; kus; l(1)G0074; l(1)G0108; l(1)G0198", "gene_names_refseq": "B-spec; CG5870; Dmel\\CG5870; SPEC8; Spec-beta; Specbeta; Spectrin; Spec; anon-EST:fe1B3; b spectrin; b-Spec; beta-Spec; beta-spectrin; beta-spec; betaHeavy-Spec; betaSpec; betaspec; beta; i168; i6; kus; l(1)G0074; l(1)G0108; l(1)G0198", "protein_names_uniprotkb": "Spectrin beta chain", "protein_names_refseq": "CG5870-PA; anon-fast-evolving-1B3; beta spectrin, isoform A; beta spectrin; beta-III-Spectrin; beta-Spec-PA; beta-spectrin; karussell", "tax_id": 7227, "disease": "spinocerebellar ataxia 5 (Disease Ontology:DOID:0050882); autosomal recessive spinocerebellar ataxia 14 (Disease Ontology:DOID:0080058); hereditary spherocytosis type 2 (Disease Ontology:DOID:0110917); hereditary spherocytosis (Disease Ontology:DOID:12971); Beckwith-Wiedemann syndrome (Disease Ontology:DOID:5572)", "pathway": " (dme:Dmel_CG5870); (R-DME-375165); (R-DME-445095); (R-DME-5673001); (R-DME-6807878); (R-DME-9013420); (R-DME-9013424)", "pathway_count": 7, "publication_count": 16, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;1631106;17569856;17569867;18327897;25589440;26109356;26109357;3680372;40245499;8591029", "class_list": "", "function": "Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Interacts with calmodulin in a calcium-dependent manner., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6NNX2;Q9VX30", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005516 calmodulin binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0008017 microtubule binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0030424 axon;GO:0031594 neuromuscular junction;GO:0016328 lateral plasma membrane", "go_biological_process": "GO:0048790 maintenance of presynaptic active zone structure;GO:0007274 neuromuscular synaptic transmission;GO:0007399 nervous system development;GO:0007409 axonogenesis;GO:0016199 axon midline choice point recognition", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q00963-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V3K3-1", "uniprot_id": [ { "id": "RUVB2_DROME", "url": "https://www.uniprot.org/uniprot/Q9V3K3", "type": "external" } ], "mass": 53541.0, "length": 481, "protein_name": "RuvB-like helicase 2", "gene_name": "rept", "organism": "Fruit fly", "refseq_name": "reptin, isoform B", "refseq_ac": [ { "id": "NP_001262040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262040", "type": "external" } ], "gene_names_uniprotkb": "rept; CG9750; Dmel\\CG9750; Dmel_CG9750; Q9V3K3_DROME; REPT; REP; Reptin; Rept; Tip48; anon-WO0142479.1; dRUVBL2; dReptin; dRep; drep; l(3)06945; psg10; rep", "gene_names_refseq": "CG9750; Dmel\\CG9750; Q9V3K3_DROME; REPT; REP; Reptin; Rept; Tip48/Reptin; Tip48; anon-WO0142479.1; dRUVBL2; dReptin; dRep; drep; l(3)06945; psg10; rept; rep", "protein_names_uniprotkb": "RuvB-like helicase 2; 3.6.4.12; Dreptin; Drep; Reptin", "protein_names_refseq": "CG9750-PB; dReptin; rept-PB; reptin, isoform B; reptin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9750)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10731132;11080158;12537568;12537569;12537572;12537573;12537574;15528408;16087886;16110336;16618800;17569856;17569867;25589440;26109356;26109357;32432549", "class_list": "", "function": "Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of histone H4 'Lys-12'. Component of a SWR1-like complex that incorporates H2A.V genome-wide and specifically at active promoters, in an ATP-dependent manner. Component of the Tip60 chromatin-remodeling complex that upon induction of DNA double-strand breaks, mediates the ATP-dependent exchange of unmodified histone H2AV for its phosphorylated and acetylated form H2AVK5acS138ph, leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the chromatin-remodeling INO80 complex. Binds beta-catenin, to positively regulate Wnt-responsive targets. Also an essential cofactor for the normal function of Myc; required for cellular proliferation and growth., [UniProtKB, UniProtKB]; Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (By similarity). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of histone H4 'Lys-12' (PubMed:32432549). Component of a SWR1-like complex that incorporates H2A.V genome-wide and specifically at active promoters, in an ATP-dependent manner (PubMed:32432549). Component of the Tip60 chromatin-remodeling complex that upon induction of DNA double-strand breaks, mediates the ATP-dependent exchange of unmodified histone H2AV for its phosphorylated and acetylated form H2AVK5acS138ph, leading to transcriptional regulation of selected genes by chromatin remodeling (PubMed:15528408). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (By similarity). Binds beta-catenin, to negatively regulate Wnt-responsive targets (PubMed:11080158). Also an essential cofactor for the normal function of Myc; required for cellular proliferation and growth (PubMed:16087886)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.-.-.-", "type": "external" }, { "id": "5.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0003714 transcription corepressor activity;GO:0016887 ATP hydrolysis activity;GO:0003678 DNA helicase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0097255 R2TP complex;GO:0005634 nucleus;GO:0031011 Ino80 complex;GO:0035267 NuA4 histone acetyltransferase complex;GO:0000812 Swr1 complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9V3K3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9GYU7-1", "uniprot_id": [ { "id": "MED10_DROME", "url": "https://www.uniprot.org/uniprot/Q9GYU7", "type": "external" } ], "mass": 15657.0, "length": 133, "protein_name": "Mediator of RNA polymerase II transcription subunit 10", "gene_name": "MED10", "organism": "Fruit fly", "refseq_name": "mediator complex subunit 10, isoform C", "refseq_ac": [ { "id": "NP_001261931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261931", "type": "external" } ], "gene_names_uniprotkb": "MED10; BcDNA:SD24044; CG5057; Dmel\\CG5057; Dmel_CG5057; Med10; Nut2; dMED10; dTRAP15; l(3)72Ds; med10", "gene_names_refseq": "BcDNA:SD24044; CG5057; Dmel\\CG5057; MED10; Med10; Nut2; dMED10; dTRAP15; l(3)72Ds; med10", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 10; Mediator complex subunit 10; dMED10; dTRAP15", "protein_names_refseq": "CG5057-PC; MED10-PC; mediator complex subunit 10, isoform C; mediator", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5057); (R-DME-9841922)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15477388;16110336;16751183;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VUZ9", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016592 mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9GYU7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49847-1", "uniprot_id": [ { "id": "TAF6_DROME", "url": "https://www.uniprot.org/uniprot/P49847", "type": "external" } ], "mass": 65654.0, "length": 606, "protein_name": "Transcription initiation factor TFIID subunit 6", "gene_name": "Taf6", "organism": "Fruit fly", "refseq_name": "TBP-associated factor 6, isoform A", "refseq_ac": [ { "id": "NP_524161", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524161", "type": "external" } ], "gene_names_uniprotkb": "Taf6; 62; CG32211; CG9348; Dmel\\CG32211; Dmel_CG32211; SR3-4B; TAF60; TAF6; TAFII60(62); TAFII60; TAFII62; TAF[[II]]60; TAF[[II]]62; TAF[[II]]; TAF; TFIID 62; TFIID; Taf-6; Taf60; Taf62; Taf[[II]]60; d60; dTAF62; dTAF6; dTAFII62; dTAF[[II]]262; dTAF[[II]]60; dTAF[[II]]62; dmTAF6; dme-TAFII60; l(3)76BDf; p62; taf60; taf6", "gene_names_refseq": "CG32211; CG9348; Dmel\\CG32211; SR3-4B; TAF60/62; TAF60; TAF6; TAFII60(62); TAFII60; TAFII62; TAF[[II]]60/62; TAF[[II]]60; TAF[[II]]62; TAF[[II]]; TAF; TFIID 62; TFIID; Taf-6; Taf60; Taf62; Taf6; Taf[[II]]60; d60; dTAF62; dTAF6; dTAFII62; dTAF[[II]]262; dTAF[[II]]60; dTAF[[II]]62; dmTAF6; dme-TAFII60; l(3)76BDf; p62; taf60; taf6", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 6; TAFII-60; TAFII-62; Transcription initiation factor TFIID 62 kDa subunit; p62", "protein_names_refseq": "CG32211-PA; TBP associated factor 60; TBP-Associated factor 6; TBP-associated factor 6, isoform A; TBP-associated factor 60kD; Taf6-PA; suppressor of Ras85D 3-4B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32211); (R-DME-674695); (R-DME-6804756); (R-DME-6807505); (R-DME-73776); (R-DME-73779); (R-DME-75953); (R-DME-76042)", "pathway_count": 8, "publication_count": 17, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;40245499;7545910;8262073;8598927", "class_list": "", "function": "TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q961B6;Q9VW16", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0046982 protein heterodimerization activity;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005669 transcription factor TFIID complex;GO:0000124 SAGA complex;GO:0046695 SLIK (SAGA-like) complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P49847-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V9N1-1", "uniprot_id": [ { "id": "IR40A_DROME", "url": "https://www.uniprot.org/uniprot/Q9V9N1", "type": "external" } ], "mass": 84084.0, "length": 732, "protein_name": "Ionotropic receptor 40a", "gene_name": "Ir40a", "organism": "Fruit fly", "refseq_name": "ionotropic receptor 40a, isoform F", "refseq_ac": [ { "id": "NP_610140", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610140", "type": "external" } ], "gene_names_uniprotkb": "Ir40a; 40a; CG42352; CG5922; CG5929; DmelIR40a; Dmel\\CG42352; Dmel_CG42352; IR40a; Ir40A", "gene_names_refseq": "40a; CG42352; CG5922; CG5929; DmelIR40a; Dmel\\CG42352; IR40a; Ir40A; Ir40a", "protein_names_uniprotkb": "Ionotropic receptor 40a", "protein_names_refseq": "CG42352-PF; Ir40a-PF; ionotropic receptor 40a, isoform F; ionotropic receptor 40a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG42352)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;27161501;27656904", "class_list": "", "function": "Integral part of a neural sensory system in the antenna that provides the neural basis for the response to environmental changes in humidity (hygrosensation) (PubMed:27161501, PubMed:27656904). Together with Ir25a and Ir93a, mediates the response of the hygrosensory sacculus neurons to changes in relative humidity and is required for dry detection behavior (PubMed:27161501, PubMed:27656904)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B3DNK0", "ec_number_list": [], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0050907 detection of chemical stimulus involved in sensory perception", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9V9N1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q960X4-1", "uniprot_id": [ { "id": "TIP60_DROME", "url": "https://www.uniprot.org/uniprot/Q960X4", "type": "external" } ], "mass": 61234.0, "length": 541, "protein_name": "Histone acetyltransferase Tip60", "gene_name": "Tip60", "organism": "Fruit fly", "refseq_name": "Tat interactive protein 60kDa, isoform C", "refseq_ac": [ { "id": "NP_001259234", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259234", "type": "external" } ], "gene_names_uniprotkb": "Tip60; 6121; CG6121; DmEG0007.7; Dmel\\CG6121; Dmel\\TIP60; Dmel_CG6121; EG0007.7; EG:EG0007.7; TIP-60; TIP60; dTIP60; dTip60; dmHAG405; tip60", "gene_names_refseq": "6121; CG6121; DmEG0007.7; Dmel/TIP60; Dmel\\CG6121; Dmel\\TIP60; EG0007.7; EG:EG0007.7; TIP-60; TIP60; Tip60; dTIP60; dTip60; dmHAG405; tip60", "protein_names_uniprotkb": "Histone acetyltransferase Tip60; 2.3.1.48; Tat interactive protein 60kDa", "protein_names_refseq": "CG6121-PC; Tat interactive protein 60kDa, isoform C; Tat-interactive protein-60 KDa; Tat-interactive protein; Tip60-PC", "tax_id": 7227, "disease": "iron deficiency anemia (Disease Ontology:DOID:11758); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG6121); (R-DME-201722); (R-DME-2559586); (R-DME-5693548); (R-DME-5693565); (R-DME-5693607); (R-DME-9018519)", "pathway_count": 7, "publication_count": 16, "publication_id_list": "10731132;10731137;12537568;12537569;12537572;12537573;12537574;15528408;16110336;17569856;17569867;22178397;25589440;26109356;26109357;32432549", "class_list": "", "function": "Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of histone H4 'Lys-12' (PubMed:32432549). Catalytic subunit of the Tip60 chromatin-remodeling complex which is involved in DNA repair; upon induction of DNA double-strand breaks, acetylates phosphorylated histone H2AV in nucleosomes on 'Lys-5' and exchanges it with unmodified H2AV (PubMed:15528408). Upon heat shock, acetylates histone H2A on 'Lys-6' (H2AK5ac) in a Hsf-dependent manner, which activates Parp1 resulting in poly-ADP-ribosylation of histones within the Hsp70 gene locus; required for transcriptional activation of Hsp70 (PubMed:22178397)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "M9PGN1;O97425", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.3.1.311", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.311", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:1990188 euchromatin binding;GO:0004402 histone acetyltransferase activity;GO:0046972 histone H4K16 acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0035267 NuA4 histone acetyltransferase complex;GO:0000123 histone acetyltransferase complex;GO:0005705 polytene chromosome interband;GO:0000785 chromatin", "go_biological_process": "GO:2000331 regulation of terminal button organization;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0048167 regulation of synaptic plasticity", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q960X4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24025-1", "uniprot_id": [ { "id": "SOG_DROME", "url": "https://www.uniprot.org/uniprot/Q24025", "type": "external" } ], "mass": 115515.0, "length": 1038, "protein_name": "Dorsal-ventral patterning protein Sog", "gene_name": "sog", "organism": "Fruit fly", "refseq_name": "short gastrulation, isoform B", "refseq_ac": [ { "id": "NP_001259576", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259576", "type": "external" } ], "gene_names_uniprotkb": "sog; CG9224; Dm sog; Dmel\\CG9224; Dmel_CG9224; SOG; Sog; l(1)G0160; l(1)G0395; l(1)G0479", "gene_names_refseq": "CG9224; Dm sog; Dmel\\CG9224; SOG; Sog; l(1)G0160; l(1)G0395; l(1)G0479; sog", "protein_names_uniprotkb": "Dorsal-ventral patterning protein Sog; Short gastrulation protein", "protein_names_refseq": "CG9224-PB; chordin; short gastrulation, isoform B; short gastrulation; short of gastrulation; short-gastrulation; sog-PB", "tax_id": 7227, "disease": "DiGeorge syndrome (Disease Ontology:DOID:11198); velocardiofacial syndrome (Disease Ontology:DOID:12583)", "pathway": " (dme:Dmel_CG9224)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;11260716;12537568;12537572;12537573;12537574;14534137;15872004;16110336;17569856;17569867;20599894;25589440;26109356;26109357;7958919", "class_list": "", "function": "Putative negative growth factor (PubMed:7958919). Antagonist of dpp, a protein involved in patterning the dorsal region and in the development of the neuroectoderm; dpp inhibition is enhanced by tsg (PubMed:14534137, PubMed:7958919). Required for establishment of a narrow stripe of peak levels of BMP signaling in the dorsal midline of early embryos, that will give rise to the amnioserosa (PubMed:11260716, PubMed:14534137). During pupal development, plays a role in specification of the posterior crossvein in the wing (PubMed:15872004). Exhibits both agonist and antagonist activities towards BMP signaling during pupal wing patterning (PubMed:15872004)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Putative negative growth factor. Antagonist of dpp, a protein involved in patterning the dorsal region and in the development of the neuroectoderm; dpp inhibition is enhanced by tsg. Required for establishment of a narrow stripe of peak levels of BMP signaling in the dorsal midline of early embryos, that will give rise to the amnioserosa., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "B7FNI9;Q9VXS7", "ec_number_list": [], "go_molecular_function": "GO:0005518 collagen binding;GO:0008083 growth factor activity;GO:0036122 BMP binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0030514 negative regulation of BMP signaling pathway;GO:0030513 positive regulation of BMP signaling pathway;GO:0009953 dorsal/ventral pattern formation;GO:0007313 maternal specification of dorsal/ventral axis, oocyte, soma encoded;GO:0035271 ring gland development", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q24025-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27580-1", "uniprot_id": [ { "id": "SAHH_DROME", "url": "https://www.uniprot.org/uniprot/Q27580", "type": "external" } ], "mass": 47366.0, "length": 432, "protein_name": "Adenosylhomocysteinase", "gene_name": "Ahcy", "organism": "Fruit fly", "refseq_name": "adenosylhomocysteinase, isoform C", "refseq_ac": [ { "id": "NP_001285268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285268", "type": "external" } ], "gene_names_uniprotkb": "Ahcy; Ahcy13; CG11654; Dmel\\CG11654; Dmel_CG11654; SAHH; ahcY", "gene_names_refseq": "Ahcy13; Ahcy; CG11654; Dmel\\CG11654; SAHH; ahcY", "protein_names_uniprotkb": "Adenosylhomocysteinase; 3.13.2.1; AdoHcyase; S-adenosyl-L-homocysteine hydrolase", "protein_names_refseq": "AdoHcyase; Ahcy-PC; CG11654-PC; S-Adenosyl-L-homocysteine hydrolase; adenosylhomocysteinase at 13; adenosylhomocysteinase, isoform C; adenosylhomocysteinases", "tax_id": 7227, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase (Disease Ontology:DOID:0111039); abdominal aortic aneurysm (Disease Ontology:DOID:7693); pyridoxine deficiency anemia (Disease Ontology:DOID:8455); hyperhomocysteinemia (Disease Ontology:DOID:9279); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (dme:Dmel_CG11654); (R-DME-156581); (R-DME-1614635)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;27313316;40971386;9037110", "class_list": "", "function": "Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine (Probable). Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore this protein may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine (Probable). Acts as a redox sensor required for rapid regulation of transcription in response to light-induced oxidative stress in photoreceptors; independent of H3K4me3 or H3K27me3 histone methylation (PubMed:40971386)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MZI1;Q9VXV5", "ec_number_list": [ { "id": "3.13.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.13.2.1", "type": "external" } ], "go_molecular_function": "GO:0004013 adenosylhomocysteinase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006730 one-carbon metabolic process;GO:0033353 S-adenosylmethionine cycle", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q27580-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24306-1", "uniprot_id": [ { "id": "DIAP1_DROME", "url": "https://www.uniprot.org/uniprot/Q24306", "type": "external" } ], "mass": 48038.0, "length": 438, "protein_name": "Death-associated inhibitor of apoptosis 1", "gene_name": "Diap1", "organism": "Fruit fly", "refseq_name": "Death-associated inhibitor of apoptosis 1, isoform D", "refseq_ac": [ { "id": "NP_001261916", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261916", "type": "external" } ], "gene_names_uniprotkb": "Diap1; 01; 03; CG12284; D-IAP1; D-iap1; DIAP I; DIAP-1; DIAP1; DIAPI; DIAP; DIAp; Diap-1; Diap; Dmel\\CG12284; Dmel_CG12284; E(rpr)3-1; E3; IAP1; IAP; Iap1; Iap; S048915; TH; Thread; Th; dIAP-1; dIAP1; dIAP; dIap1; diap 1; diap-1; diap1; diap; l(3)72CDe; l(3)72Dc; l(3)S030605b; l(3)S030605; l(3)S106503; l(3)j5C8; thread; th", "gene_names_refseq": "0736/01; 1065/03; CG12284; D-IAP1; D-iap1; DIAP I; DIAP-1; DIAP1; DIAPI; DIAP; DIAp; Diap-1/Th; Diap-1; Diap1; Diap; Dmel\\CG12284; E(rpr)3-1; E3; IAP1; IAP; Iap1; Iap; S048915; TH; Thread; dIAP-1; dIAP1; dIAP; dIap1; diap 1; diap-1; diap1/thread; diap1; diap; l(3)72CDe; l(3)72Dc; l(3)S030605b; l(3)S030605; l(3)S106503; l(3)j5C8; thread; th", "protein_names_uniprotkb": "Death-associated inhibitor of apoptosis 1; 2.3.2.27; Apoptosis 1 inhibitor; E3 ubiquitin-protein ligase th; Inhibitor of apoptosis 1; Protein thread; RING-type E3 ubiquitin transferase Diap1", "protein_names_refseq": "CG12284-PD; DIAP1; Death-associated inhibitor of apoptosis 1, isoform D; Diap1-PD; degradation of inhibitors of apoptosis; drosophila IAP1; drosophila inhibitor of apoptosis 1; drosophila inhibitor of apoptosis Protein-1; drosophila inhibitor of apoptosis protein 1; drosophila inhibitor of apoptosis protein; drosophila inhibitor-of-apoptosis protein 1; drosophila thread/inhibitor of apoptosis protein-1; inhibitor of apoptosis protein 1; inhibitor of apoptosis-1; inhibitor of apoptotic protein 1; inhibitors of apoptosis protein; lethal (3) 72CDe; thread", "tax_id": 7227, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (Disease Ontology:DOID:0050909); X-linked lymphoproliferative syndrome 2 (Disease Ontology:DOID:0060706); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); colorectal carcinoma (Disease Ontology:DOID:0080199); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); colon cancer (Disease Ontology:DOID:219); breast ductal carcinoma (Disease Ontology:DOID:3007); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); esophagus adenocarcinoma (Disease Ontology:DOID:4914); gallbladder carcinoma (Disease Ontology:DOID:4948); hepatocellular carcinoma (Disease Ontology:DOID:684); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dme:Dmel_CG12284); (R-DME-111459); (R-DME-111469); (R-DME-3769402); (R-DME-390150); (R-DME-5675482); (R-DME-8948747); (R-DME-8948751); (R-DME-9627069); (R-DME-9958825)", "pathway_count": 10, "publication_count": 31, "publication_id_list": "10675329;10731132;10984473;11511363;11550090;12537568;12537569;12537572;12537573;12537574;12941274;14502295;14517550;16110336;17174922;17397804;17569856;17569867;18259196;19217783;19710173;21145488;22095281;22304967;25146930;25589440;26109356;26109357;26383956;27462444;8548811", "class_list": "", "function": "Anti-apoptotic protein which functions as a caspase regulator, using its E3 ubiquitin-protein ligase activity to smother caspase activity. Binds, ubiquitinates and inactivates initiator caspase Dronc, and effector caspases Drice and Dcp-1. Acts as a Nedd8-E3 ubiquitin-protein ligase for Drice. Suppresses apoptosis by targeting the apoptosome for ubiquitination and inactivation. Plays an important role in cell motility. Overexpression suppresses rpr and hid-dependent cell death in the eye. Interaction of Diap1 with Dronc is required to suppress Dronc-mediated cell death through Diap1-mediated ubiquitination of Dronc. Acts as a positive regulator of Wnt signaling., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A4V1Z9;A9UN33;Q0E8E4;Q8MRM5;Q9VUX5", "ec_number_list": [ { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.22.61", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.61", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0016055 Wnt signaling pathway;GO:0031398 positive regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q24306-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55035-1", "uniprot_id": [ { "id": "PSMD4_DROME", "url": "https://www.uniprot.org/uniprot/P55035", "type": "external" } ], "mass": 42618.0, "length": 396, "protein_name": "26S proteasome non-ATPase regulatory subunit 4", "gene_name": "Rpn10", "organism": "Fruit fly", "refseq_name": "regulatory particle non-ATPase 10, isoform B", "refseq_ac": [ { "id": "NP_001262168", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262168", "type": "external" } ], "gene_names_uniprotkb": "Rpn10; 5SA; 7619; CG7619; DmS5a; Dmel\\CG7619; Dmel_CG7619; PROS-54; Pros54; S5A; S5a; dRpn10; mu-54; p54; pros54; rpn10", "gene_names_refseq": "5SA; 7619; CG7619; DmS5a; Dmel\\CG7619; Pros54; Rpn10/p54; Rpn10; S5A; S5a; dRpn10; mu-54; p54; pros54; rpn10", "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 4; 26S proteasome regulatory subunit RPN10; 26S proteasome regulatory subunit S5A; 54 kDa subunit of mu particle; Multiubiquitin chain-binding protein; p54", "protein_names_refseq": "54 kda mu particle subunit of 26S protease; CG7619-PB; Rpn10-PB; proteasome 54kD subunit; regulatory particle non-ATPase 10, isoform B; subunit S5a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7619); (R-DME-209360); (R-DME-209406); (R-DME-209461); (R-DME-216167); (R-DME-432395); (R-DME-432524); (R-DME-432626); (R-DME-538864); (R-DME-9907900)", "pathway_count": 10, "publication_count": 46, "publication_id_list": "10102270;10417378;10458606;10481010;10731132;11585911;11862484;12231619;12432393;12442174;12537568;12537569;12537572;12537573;12537574;12973300;15178801;15258584;15331761;16110336;16139204;16299518;16326393;16386907;16543224;16603629;16651542;16740475;16794082;17102630;17569856;17569867;17925225;18519643;18593878;19185492;25589440;26109356;26109357;7649173;7705656;8948598;9025065;9215627;9553105;9990853", "class_list": "", "function": "Binds and presumably selects ubiquitin-conjugates for destruction., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q86R87;Q9V473", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0008540 proteasome regulatory particle, base subcomplex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0000070 mitotic sister chromatid segregation", "synthesized_glycan_count": 0, "hit_score": 4.7, "record_id": "P55035-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VK71-1", "uniprot_id": [ { "id": "PDM2B_DROME", "url": "https://www.uniprot.org/uniprot/Q9VK71", "type": "external" } ], "mass": 98465.0, "length": 893, "protein_name": "POU domain protein 2, isoform B", "gene_name": "pdm2", "organism": "Fruit fly", "refseq_name": "POU domain protein 2, isoform C", "refseq_ac": [ { "id": "NP_001285877", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285877", "type": "external" } ], "gene_names_uniprotkb": "pdm2; CG12287; CG15486; CG15487; Dmel\\CG12287; Dmel_CG12287; Miti; OCT2; Oct-2; Oct2; POU-28; Pdm-2; Pdm2; Pdm; dOct2; dPOU-28; dPOU28; dim; dpou28; miti; pdm-2; pdm", "gene_names_refseq": "CG12287; CG15486; CG15487; Dmel\\CG12287; Miti; Oct-2; Oct2; Pdm-2; Pdm2; Pdm; dOct2; dPOU-28; dPOU28/pdm-2; dPOU28; dim; dpou28; miti; pdm-2; pdm2; pdm", "protein_names_uniprotkb": "POU domain protein 2, isoform B; Miti-mere; Pdm-2; Protein didymous; dOct2; dPOU-28", "protein_names_refseq": "CG12287-PC; Miti-mere; POU domain prot 2; POU domain protein 2, isoform C; didymous; pdm2-PC", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12287)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;1496003;16110336;1680380;1685891;17569856;17569867;18327897;1881906;25589440;26109356;26109357", "class_list": "", "function": "DNA-binding regulatory protein implicated in early development. Involved in neuronal cell fate decision. May act as an octamer-dependent activator of transcription. Could also play an early role in specific ectodermal cells, and a subsequent role in the embryonic nervous system., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6NR25", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0007417 central nervous system development;GO:0007398 ectoderm development;GO:0048699 generation of neurons", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9VK71-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49021-4", "uniprot_id": [ { "id": "TIM_DROME", "url": "https://www.uniprot.org/uniprot/P49021", "type": "external" } ], "mass": 156382.0, "length": 1398, "protein_name": "Protein timeless", "gene_name": "tim", "organism": "Fruit fly", "refseq_name": "timeless, isoform S", "refseq_ac": [ { "id": "NP_001014463", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014463", "type": "external" } ], "gene_names_uniprotkb": "tim; CG3234", "gene_names_refseq": "CG3234; Dmel\\CG3234; Ritsu; TIM; Tim-1; Tim; dTIM; dTim; dtim; mel_tim; rit; s-tim; tim1; tim", "protein_names_uniprotkb": "Protein timeless", "protein_names_refseq": "CG3234-PS; TIMELESS; bruchpilot; dtimeless; ritsu; tim-PS; timeless, isoform S; timeless1", "tax_id": 7227, "disease": "advanced sleep phase syndrome (Disease Ontology:DOID:0050628)", "pathway": " (dme:Dmel_CG3234); (R-DME-432395); (R-DME-432490); (R-DME-432501); (R-DME-432553); (R-DME-432620); (R-DME-538898)", "pathway_count": 7, "publication_count": 51, "publication_id_list": "10409723;10417378;10481010;10684876;10731132;11430804;11440719;11585911;12122057;12432393;12442174;12447397;12537569;12537572;12546820;12563262;12581523;12944510;14759367;14980226;15178801;15258584;15930393;16319317;16410523;16543224;16603629;16794082;17418796;17452449;17575052;18474612;18593878;18815259;19139270;19185492;19726650;20159956;7481771;7481772;7481773;8128247;8596938;8600384;8625406;8938123;9016581;9365248;9504927;9674431;9808471", "class_list": "", "function": "Required for the production of circadian rhythms. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4V040;B7Z007;B7Z008;C9QPB7;M9MRE9;O44380;Q1WWF5;Q59E16;Q8I037;Q95U67;Q9VQR6;Q9VQR7", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0031298 replication fork protection complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000076 DNA replication checkpoint signaling;GO:0060086 circadian temperature homeostasis;GO:0045187 regulation of circadian sleep/wake cycle, sleep;GO:0006281 DNA repair;GO:0007617 mating behavior", "synthesized_glycan_count": 0, "hit_score": 5.2, "record_id": "P49021-4", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49028-1", "uniprot_id": [ { "id": "MGN_DROME", "url": "https://www.uniprot.org/uniprot/P49028", "type": "external" } ], "mass": 17311.0, "length": 147, "protein_name": "Protein mago nashi", "gene_name": "mago", "organism": "Fruit fly", "refseq_name": "mago nashi", "refseq_ac": [ { "id": "NP_476636", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476636", "type": "external" } ], "gene_names_uniprotkb": "mago; CG9401; mgn", "gene_names_refseq": "CG9401; Dm MGN; DmMago; Dmel\\CG9401; MAGOH; MAGO; MGN; Magoh; Mago; l(2)57Ca; mago; mgn", "protein_names_uniprotkb": "Protein mago nashi", "protein_names_refseq": "CG9401-PA; mago nashi; mago nishi; mago-PA; mago-nashi", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9401); (R-DME-159236); (R-DME-72163); (R-DME-975957)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10731132;12537569;12537572;12704080;12730685;14968132;14973490;20946982;20946983;24967911;8026338;9210377;9272960", "class_list": "", "function": "Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs (PubMed:14973490, PubMed:24967911). Involved in exon definition of genes containing long introns, including the rolled/MAPK gene (PubMed:20946982, PubMed:20946983). The mago-tsu heterodimer interacts with the EJC key regulator Pym leading to EJC disassembly in the cytoplasm (PubMed:24967911). Has a role in oskar mRNA localization to the posterior pole of the developing oocyte, and may also be involved in polarization of the oocyte microtubule cytoskeleton (PubMed:8026338, PubMed:9272960)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W2L3", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0071013 catalytic step 2 spliceosome;GO:0071011 precatalytic spliceosome;GO:0035145 exon-exon junction complex", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0051170 import into nucleus;GO:0008380 RNA splicing;GO:0008104 intracellular protein localization;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P49028-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49846-1", "uniprot_id": [ { "id": "TAF5_DROME", "url": "https://www.uniprot.org/uniprot/P49846", "type": "external" } ], "mass": 79325.0, "length": 704, "protein_name": "Transcription initiation factor TFIID subunit 5", "gene_name": "Taf5", "organism": "Fruit fly", "refseq_name": "TBP-associated factor 5", "refseq_ac": [ { "id": "NP_476957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476957", "type": "external" } ], "gene_names_uniprotkb": "Taf5; CG7704; TAF80", "gene_names_refseq": "CG7704; Dmel\\CG7704; TAF5; TAF80/85; TAF80; TAFII80; TAFII85; TAF[II]80; TAF[[II]]80/85; TAF[[II]]80; TAF[[II]]85; TAF[[II]]; TAF; TFIID 85; TFIID; Taf5; Taf80; Taf85; Taf[[II]]80; d80; dTAF5; dTAFII85; dTAF[[II]]80; dTAFii80; dmTAF5; dmTaf5; p85; taf5", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 5; TAFII-80; Transcription initiation factor TFIID 85 kDa subunit; p85", "protein_names_refseq": "CG7704-PA; TBP associated factor 80; TBP-associated factor 5; TBP-associated factor 80kD; TBP-associated factor 80; TBP-associated factor; Taf5-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7704); (R-DME-674695); (R-DME-6804756); (R-DME-6807505); (R-DME-73776); (R-DME-73779); (R-DME-75953); (R-DME-76042); (R-DME-9907900)", "pathway_count": 9, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;8247000;8483503", "class_list": "", "function": "TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. May play a role in helping to anchor Taf4 within the TFIID complex. May be involved in transducing signals from various transcriptional regulators to the RNA polymerase II transcription machinery., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9V5R1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0006367 transcription initiation at RNA polymerase II promoter", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P49846-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50245-1", "uniprot_id": [ { "id": "SAHH3_DROME", "url": "https://www.uniprot.org/uniprot/P50245", "type": "external" } ], "mass": 54241.0, "length": 492, "protein_name": "Adenosylhomocysteinase-like 2", "gene_name": "AhcyL2", "organism": "Fruit fly", "refseq_name": "adenosylhomocysteinase like 2, isoform D", "refseq_ac": [ { "id": "NP_996221", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996221", "type": "external" } ], "gene_names_uniprotkb": "AhcyL2; AHCY; Ahcy89E; CG8956; Dmel\\CG8956; Dmel_CG8956; IRBIT2; S-AHCY; dAhcyL2; pH200", "gene_names_refseq": "AHCY; Ahcy89E; AhcyL2; CG8956; Dmel\\CG8956; IRBIT2; S-AHCY; dAhcyL2; pH200", "protein_names_uniprotkb": "Adenosylhomocysteinase-like 2; Inactive S-adenosyl-L-homocysteine hydrolase 2; S-adenosylhomocysteine hydrolase-like protein 2; dAhcyL2", "protein_names_refseq": "AdoHcyase-like; AhcyL2-PD; CG8956-PD; S-adenosyl homocysteine hydrolase-like; adenosylhomocysteinase 89E; adenosylhomocysteinase like 2, isoform D", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8956); (R-DME-5578775)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;27313316;2903049;7667301;9037110", "class_list": "", "function": "Might play a role in the regulation of methionine metabolism., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q27587;Q8MYX7;Q9VEQ4", "ec_number_list": [ { "id": "3.13.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.13.2.1", "type": "external" } ], "go_molecular_function": "GO:0004013 adenosylhomocysteinase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006730 one-carbon metabolic process;GO:0033353 S-adenosylmethionine cycle", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P50245-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50882-1", "uniprot_id": [ { "id": "RL9_DROME", "url": "https://www.uniprot.org/uniprot/P50882", "type": "external" } ], "mass": 21392.0, "length": 190, "protein_name": "Large ribosomal subunit protein uL6", "gene_name": "RpL9", "organism": "Fruit fly", "refseq_name": "ribosomal protein L9, isoform C", "refseq_ac": [ { "id": "NP_001285826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285826", "type": "external" } ], "gene_names_uniprotkb": "RpL9; CG6141; Dmel\\CG6141; Dmel_CG6141; L6; L9; M(2)32D; Rp L9; Rpl9; anon-EST:fe3A6; anon-WO0153538.25; anon-WO0153538.26; anon-WO0153538.27; rpL9", "gene_names_refseq": "CG6141; Dmel\\CG6141; L6; L9; M(2)32D; Rp L9; RpL9; Rpl9; anon-EST:fe3A6; anon-WO0153538.25; anon-WO0153538.26; anon-WO0153538.27; rpL9", "protein_names_uniprotkb": "Large ribosomal subunit protein uL6; 60S ribosomal protein L9", "protein_names_refseq": "CG6141-PC; RpL9-PC; anon-fast-evolving-3A6; ribosomal protein L9, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6141); (R-DME-156827); (R-DME-1799339); (R-DME-72689); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954709); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 10, "publication_count": 14, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;23636399;25589440;26109356;26109357;40245499;8676882", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4V0M0;Q4V5D8;Q9VKL6;Q9VKL7", "ec_number_list": [], "go_molecular_function": "GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022626 cytosolic ribosome;GO:0022625 cytosolic large ribosomal subunit;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P50882-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50887-1", "uniprot_id": [ { "id": "RL22_DROME", "url": "https://www.uniprot.org/uniprot/P50887", "type": "external" } ], "mass": 30611.0, "length": 299, "protein_name": "Large ribosomal subunit protein eL22", "gene_name": "RpL22", "organism": "Fruit fly", "refseq_name": "ribosomal protein L22", "refseq_ac": [ { "id": "NP_477134", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477134", "type": "external" } ], "gene_names_uniprotkb": "RpL22; CG7434", "gene_names_refseq": "CG7434; Dmel\\CG7434; EG:BACR19J1.4; L22e; L22; PBP-12; RL22_DROME; RL22; RPL22; Rp L22; RpL22; Rpl22; anon-EST:Posey53; eRpL22; rpL22; rpl22", "protein_names_uniprotkb": "Large ribosomal subunit protein eL22; 60S ribosomal protein L22", "protein_names_refseq": "60S RIBOSOMAL PROTEIN L22; CG7434-PA; PARP-binding protein-12; RpL22-PA; ribosomal protein L22", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7434); (R-DME-156827); (R-DME-1799339); (R-DME-72689); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954709); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 10, "publication_count": 6, "publication_id_list": "10731132;10731137;12537569;12537572;23636399;9931508", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1EC97;Q9UAN1;Q9V3X9", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022626 cytosolic ribosome;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P50887-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51023-1", "uniprot_id": [ { "id": "PNT_DROME", "url": "https://www.uniprot.org/uniprot/P51023", "type": "external" } ], "mass": 77683.0, "length": 718, "protein_name": "ETS-like protein pointed", "gene_name": "pnt", "organism": "Fruit fly", "refseq_name": "pointed, isoform E", "refseq_ac": [ { "id": "NP_001262872", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262872", "type": "external" } ], "gene_names_uniprotkb": "pnt; CG17077; DMPOINT1A; ETS2; Ets58AB; pointed", "gene_names_refseq": "0123/09; 0608/07; 0998/12; 3520; CG17077; D-Ets-2; D-ets-2; DMPOINT1A; Dmel\\CG17077; E(E2F)3D; EC3-2; EK3-2; ETS2; EY3-1; Ets1/2; Ets2; Ets58AB; Ets94F; Ets; PNT-P1; PNTP1; PNTP2; PNT; POINT; Pnt-P1; Pnt2; PntP1; PntP2; Pnt; Pointed-P1; Pointed; ets94F; l(3)07825; l(3)j1B7; l(3)s118306; png; pnt-P1; pnt-P2; pnt.P1; pntP2; pntegfr; pnt; pointed-RC; ptd", "protein_names_uniprotkb": "ETS-like protein pointed", "protein_names_refseq": "CG17077-PE; Ets at 58AB; Ets protein pointed P2; Point2; Pointed2; no terminal cell clones-R; pnt-PE; pointed P1; pointed P2; pointed, isoform E; pointed-P1; pointed-P2; pointedP2", "tax_id": 7227, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dme:Dmel_CG17077); (R-DME-2559585)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10731132;12537569;12537572;1577186;22143802;23757412;27151950;27510969;28245922;2834248;28899667;8033205;8223245", "class_list": "", "function": "ETS transcription factor with a prominent role during development of the eye and the nervous system (PubMed:23757412, PubMed:28245922, PubMed:8033205, PubMed:8223245). Required for glial-neuronal cell interactions at the ventral midline which are necessary for the proper elaboration of commissures in the embryonic CNS (PubMed:8223245)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Required for normal EGFR-induced photoreceptor development (PubMed:23757412). Following transcriptional activation by isoform P2, acts as a constitutive activator of transcription, leading to induction of target genes essential for photoreceptor development (PubMed:23757412, PubMed:8033205). In larval brains, involved in the maintenance of type II neuroblast self-renewal and identity together with brat, btd and pros; prevents intermediate neuronal progenitor (INP) dedifferentiation by regulating the expression of erm probably via Notch signaling; suppresses Ase expression in type II neuroblasts and promotes the generation of intermediate neuronal progenitors (PubMed:22143802, PubMed:27151950, PubMed:27510969, PubMed:28245922, PubMed:28899667)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Required for normal EGFR-induced photoreceptor development probably as a downstream effector of Ras85D (PubMed:23757412, PubMed:8033205). In larval eye imaginal disks, activated by MAPK phosphorylation following EGFR activation, induces transcription of isoform P1 which in turn activates transcription of target genes essential for photoreceptor development (PubMed:23757412)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4KH96;B9EQV8;H8F4R1;P19420;P51022;Q29R53;Q8IG92;Q8IMZ1;Q9VCN2", "ec_number_list": [], "go_molecular_function": "GO:0000976 transcription cis-regulatory region binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P51023-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51521-1", "uniprot_id": [ { "id": "OVO_DROME", "url": "https://www.uniprot.org/uniprot/P51521", "type": "external" } ], "mass": 146788.0, "length": 1351, "protein_name": "Transcriptional regulator ovo", "gene_name": "ovo", "organism": "Fruit fly", "refseq_name": "ovo, isoform D", "refseq_ac": [ { "id": "NP_001033831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033831", "type": "external" } ], "gene_names_uniprotkb": "ovo; CG6824; svb", "gene_names_refseq": "CG15467; CG6824; Dmel\\CG6824; Fs(1)K1103; Fs(1)K1237; Fs(1)K155; OVO; Ovo-D; Ovo; Shv; Svb/Ovo; Svb; fs(1)K1237; fs(1)M1; fs(1)M38; ovo/shavenbaby; ovo/svb; ovoD; ovo; svb/ovo; svb", "protein_names_uniprotkb": "Transcriptional regulator ovo; Transcriptional repressor shavenbaby; Transcriptional repressor svb", "protein_names_refseq": "CG6824-PD; ovo, isoform D; ovo-PD; ovo/shaven-baby; shaven baby; shavenbaby", "tax_id": 7227, "disease": "posterior polymorphous corneal dystrophy 1 (Disease Ontology:DOID:0110855)", "pathway": " (dme:Dmel_CG6824)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "10421370;10525184;10637336;10648246;10731132;11290304;12051822;12537569;12537572;12915226;15371353;1712294;17246162;20647469;2116356;21527259;25344753;26383956;28059165;28506986;3428601;7748792;7935398;8652413;9012532;9634487", "class_list": "", "function": "Transcriptional activator which initiates trichome development and also promotes tarsal joint development (PubMed:20647469, PubMed:21527259, PubMed:26383956). Has an essential somatic role regulating the tal-dependent formation of trichomes, and initiating cytoskeletal remodeling during epidermal differentiation (PubMed:20647469, PubMed:21527259, PubMed:25344753, PubMed:26383956). Function with SoxN is required for correct denticle morphogenesis on the embryonic epidermis (PubMed:28506986). SoxN and svb appear to act both independently and in conjunction with each other to activate certain genes involved in denticle morphogenesis; Svb appears to be involved in regulating denticle length whereas SoxN regulates the denticle base circumference (PubMed:28506986). Also functions in the development of other apical cell extensions such as bristles (PubMed:25344753). Also has an important role in tarsal joint development, repressing expression of the N ligand Dl and defining its signaling boundary (PubMed:21527259)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Transcriptional activator which is specifically involved in female germline development, where it functions antagonistically to isoform C (PubMed:10648246, PubMed:1712294, PubMed:3428601, PubMed:8652413). Necessary and sufficient for normal oogenesis (PubMed:12051822, PubMed:1712294). Required in the primordial germ cells (PGCs) for normal development of male and female germline cells (PubMed:28059165). Plays a role in germline sex determination (PubMed:2116356). Binds the promoter DNA and positively regulates the transcription of the otu gene in a stage-specific manner (PubMed:10525184, PubMed:11290304, PubMed:9634487). May have autoregulatory activity (PubMed:11290304, PubMed:9634487)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Transcriptional regulator with essential functions in the germline and soma (PubMed:10421370, PubMed:12915226, PubMed:9012532). Plays an essential role in regulating the formation of apical cell extensions such as denticles and aristae, and initiating cytoskeletal remodeling during epidermal differentiation (PubMed:10421370, PubMed:12915226)., [UniProtKB, PubMed, PubMed, PubMed]; Transcriptional repressor which functions in postembryonic development (PubMed:21527259, PubMed:26383956). The full-length unprocessed form acts as a transcriptional repressor (Transcriptional repressor svb) (PubMed:26383956)., [UniProtKB, PubMed, PubMed]; Transcriptional repressor which is specifically involved in female germline development, where it functions antagonistically to isoform D (PubMed:10648246, PubMed:28059165). Negatively regulates expression of otu and may also have autoregulatory activity (PubMed:10648246). Negatively regulates expression of piwi in the primordial germ cells (PGCs) (PubMed:28059165)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E1JJE5;O02468;Q2PE28;Q8MPN4;Q8SX56;Q8T8L9;Q9W4F0;Q9W4F1;Q9W4F2;Q9XZU4;Q9Y046", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0009913 epidermal cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P51521-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52304-1", "uniprot_id": [ { "id": "POLO_DROME", "url": "https://www.uniprot.org/uniprot/P52304", "type": "external" } ], "mass": 66974.0, "length": 576, "protein_name": "Serine/threonine-protein kinase polo", "gene_name": "polo", "organism": "Fruit fly", "refseq_name": "polo, isoform B", "refseq_ac": [ { "id": "NP_001014592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014592", "type": "external" } ], "gene_names_uniprotkb": "polo; CG12306", "gene_names_refseq": "0256/04; 1324/08; CG12306; Dmel\\CG12306; PLK1; POLO/PLK1; POLO; Plk1; Polo kinase; Polo; anon-WO0172774.3; l(3)01673; l(3)77Aa; l(3)S025604; l(3)S132408; pPolo; poloK; polo", "protein_names_uniprotkb": "Serine/threonine-protein kinase polo; 2.7.11.21", "protein_names_refseq": "CG12306-PB; polo kinase; polo protein kinase; polo, isoform B; polo-PB", "tax_id": 7227, "disease": "prostate carcinoma (Disease Ontology:DOID:10286); urinary bladder cancer (Disease Ontology:DOID:11054); ovary epithelial cancer (Disease Ontology:DOID:2152); endometriosis (Disease Ontology:DOID:289); breast carcinoma (Disease Ontology:DOID:3459)", "pathway": " (dme:Dmel_CG12306); (R-DME-156711); (R-DME-162658); (R-DME-174178); (R-DME-176412); (R-DME-176417); (R-DME-2500257); (R-DME-2565942); (R-DME-68881); (R-DME-68884); (R-DME-69273); (R-DME-9648025)", "pathway_count": 12, "publication_count": 7, "publication_id_list": "10731132;12537569;12537572;1660828;18327897;22291575;24829288", "class_list": "", "function": "May play a role in regulating both nuclear and cytoplasmic aspects of the mitotic cycle (PubMed:1660828). Regulates localization of the augmin complex during mitosis by ensuring its location on mitotic spindles (PubMed:24829288). Also regulates augmin complex localization during male meiosis by promoting its placement at kinetochores while preventing its association with spindle microtubules (PubMed:24829288)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V258;Q9VWB2", "ec_number_list": [ { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "5.6.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.8", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "5.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.5", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005828 kinetochore microtubule;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm", "go_biological_process": "GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0007147 female meiosis II;GO:0000278 mitotic cell cycle;GO:0007143 female meiotic nuclear division;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P52304-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52486-1", "uniprot_id": [ { "id": "UBCD4_DROME", "url": "https://www.uniprot.org/uniprot/P52486", "type": "external" } ], "mass": 22510.0, "length": 199, "protein_name": "Ubiquitin-conjugating enzyme E2-22 kDa", "gene_name": "Ubc4", "organism": "Fruit fly", "refseq_name": "ubiquitin conjugating enzyme 4, isoform B", "refseq_ac": [ { "id": "NP_001287013", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287013", "type": "external" } ], "gene_names_uniprotkb": "Ubc4; CG8284; Dmel\\CG8284; Dmel_CG8284; E2; UbcD4 E2; UbcD4", "gene_names_refseq": "CG8284; Dmel\\CG8284; E2; Ubc4; UbcD4 E2; UbcD4", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2-22 kDa; 2.3.2.23; E2 ubiquitin-conjugating enzyme 4; Ubiquitin carrier protein; Ubiquitin-protein ligase", "protein_names_refseq": "CG8284-PB; Ubc4-PB; ubiquitin conjugating enzyme 4, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8284); (R-DME-8866652); (R-DME-983168)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10731132;11862484;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Catalyzes the covalent attachment of ubiquitin to other proteins., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P91633", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding;GO:0004842 ubiquitin-protein transferase activity;GO:0070628 proteasome binding;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:0061059 positive regulation of peptidoglycan recognition protein signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P52486-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52654-1", "uniprot_id": [ { "id": "TF2AA_DROME", "url": "https://www.uniprot.org/uniprot/P52654", "type": "external" } ], "mass": 39268.0, "length": 366, "protein_name": "Transcription initiation factor IIA subunit 1", "gene_name": "TfIIA-L", "organism": "Fruit fly", "refseq_name": "transcription factor IIA L, isoform A", "refseq_ac": [ { "id": "NP_476995", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476995", "type": "external" } ], "gene_names_uniprotkb": "TfIIA-L; CG5930", "gene_names_refseq": "CG5930; CT18631; Dmel\\CG5930; TFIIA-L; TFIIAL; TFIIA; TfIIA-L; TfIIA; dTFIIA; tfiia-l", "protein_names_uniprotkb": "Transcription initiation factor IIA subunit 1; General transcription factor IIA subunit 1; TFIIA p20 subunit; TFIIA p30 subunit; dTFIIA-L", "protein_names_refseq": "CG5930-PA; TfIIA-L-PA; transcription factor IIA L, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5930); (R-DME-674695); (R-DME-6807505); (R-DME-73776); (R-DME-73779); (R-DME-75953); (R-DME-76042); (R-DME-9018519)", "pathway_count": 8, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;8224849", "class_list": "", "function": "TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IMN7;Q8IMN8;Q95RK0;Q9VB56", "ec_number_list": [], "go_molecular_function": "GO:0001094 TFIID-class transcription factor complex binding;GO:0017025 TBP-class protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005672 transcription factor TFIIA complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P52654-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53403-1", "uniprot_id": [ { "id": "GTR3_DROME", "url": "https://www.uniprot.org/uniprot/P53403", "type": "external" } ], "mass": 56705.0, "length": 507, "protein_name": "Glucose transporter type 3", "gene_name": "Glut3", "organism": "Fruit fly", "refseq_name": "glucose transporter type 3", "refseq_ac": [ { "id": "NP_536732", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536732", "type": "external" } ], "gene_names_uniprotkb": "Glut3; CG3853; glut-l", "gene_names_refseq": "CG3853; Dmel\\CG3853; GLU; Glut-3; Glut3; Glut; glut 3; glut-l", "protein_names_uniprotkb": "Glucose transporter type 3; Glucose transporter-like protein", "protein_names_refseq": "CG3853-PA; Glut3-PA; glucose transporter type 3; glucose transporter-like", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3853); (R-DME-189200)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;7667301", "class_list": "", "function": "Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8T4C0;Q9VER2", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0005536 D-glucose binding;GO:0055056 D-glucose transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043204 perikaryon;GO:0042995 cell projection", "go_biological_process": "GO:1904659 D-glucose transmembrane transport;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P53403-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53997-1", "uniprot_id": [ { "id": "SET_DROME", "url": "https://www.uniprot.org/uniprot/P53997", "type": "external" } ], "mass": 30995.0, "length": 269, "protein_name": "Protein SET", "gene_name": "Set", "organism": "Fruit fly", "refseq_name": "Set", "refseq_ac": [ { "id": "NP_650438", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650438", "type": "external" } ], "gene_names_uniprotkb": "Set; CG4299", "gene_names_refseq": "CG4299; Dmel\\CG4299; SET; Set; TAF-Ibeta; dSET; dSet", "protein_names_uniprotkb": "Protein SET", "protein_names_refseq": "CG4299-PA; Set-PA; Set", "tax_id": 7227, "disease": "autosomal dominant intellectual developmental disorder 58 (Disease Ontology:DOID:0061032); prostate cancer (Disease Ontology:DOID:10283); gonadal dysgenesis (Disease Ontology:DOID:14447); seminoma (Disease Ontology:DOID:4440); hepatocellular carcinoma (Disease Ontology:DOID:684); sudden infant death syndrome (Disease Ontology:DOID:9007)", "pathway": " (dme:Dmel_CG4299); (R-DME-450520)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10731132;12537569;12537572;16951084;18327897;19126864;7622566", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q540W9;Q9VFA5", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P53997-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54191-1", "uniprot_id": [ { "id": "OB69A_DROME", "url": "https://www.uniprot.org/uniprot/P54191", "type": "external" } ], "mass": 16726.0, "length": 148, "protein_name": "General odorant-binding protein 69a", "gene_name": "Obp69a", "organism": "Fruit fly", "refseq_name": "Odorant-binding protein 69a", "refseq_ac": [ { "id": "NP_524039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524039", "type": "external" } ], "gene_names_uniprotkb": "Obp69a; CG10436; Pbprp1", "gene_names_refseq": "69a; CG10436; DmelObp69a; Dmel\\CG10436; OBP69a; Obp69a; PB-PRP1; PBP1; PBPRP-1; Pbprp1; pbprp-1; pbprp1", "protein_names_uniprotkb": "General odorant-binding protein 69a; Odorant-binding protein 69a; PBPRP-1; Pheromone-binding protein-related protein 1", "protein_names_refseq": "CG10436-PA; Obp69a-PA; Odorant-binding protein 69a; Pbprp1; Pheromone-binding protein-related protein 1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10436)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537572;29630598;40245499;7545907", "class_list": "", "function": "Odorant-binding protein required for olfactory behavior and activity of pheromone-sensitive neurons in response to the male-specific pheromone cis-vaccenyl acetate (cVA). Modulates social responsivity differently in males and females, regulating male aggression and female receptivity respectively., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9VTX0", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0005549 odorant binding;GO:0008145 phenylalkylamine binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0042048 olfactory behavior;GO:0007608 sensory perception of smell;GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus;GO:0007619 courtship behavior", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P54191-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54399-1", "uniprot_id": [ { "id": "PDI_DROME", "url": "https://www.uniprot.org/uniprot/P54399", "type": "external" } ], "mass": 55781.0, "length": 496, "protein_name": "Protein disulfide-isomerase", "gene_name": "Pdi", "organism": "Fruit fly", "refseq_name": "protein disulfide isomerase, isoform E", "refseq_ac": [ { "id": "NP_001287070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287070", "type": "external" } ], "gene_names_uniprotkb": "Pdi; CG6988; Dmel\\CG6988; Dmel_CG6988; Dpdi; EP(3)1022; PDI; dpdi; l(3)j2A2; pdi", "gene_names_refseq": "CG6988; Dmel\\CG6988; Dpdi; EP(3)1022; PDI; Pdi; dpdi; l(3)j2A2; pdi", "protein_names_uniprotkb": "Protein disulfide-isomerase; 5.3.4.1; PDI; dPDI", "protein_names_refseq": "CG6988-PE; Pdi-PE; lethal (3) j2A2; proline diisomerease; protein disulfide isomerase, isoform E; protein disulfide isomerase; protein disulphide isomerase; protein-disulfide isomerase", "tax_id": 7227, "disease": "Cole-Carpenter syndrome (Disease Ontology:DOID:0060438)", "pathway": " (dme:Dmel_CG6988); (R-DME-264876); (R-DME-381426); (R-DME-5358346); (R-DME-8957275); (R-DME-8964041)", "pathway_count": 6, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15952742;16110336;17569856;17569867;25589440;26109356;26109357;7787847", "class_list": "", "function": "Participates in the folding of proteins containing disulfide bonds., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q53YH5;Q86PE2;Q8IQL8;Q9VUL7", "ec_number_list": [ { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.14.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.18.1", "type": "external" }, { "id": "1.10.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.10.3.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "1.10.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.10.3.3", "type": "external" }, { "id": "3.4.21.112", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.112", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "2.4.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.145", "type": "external" }, { "id": "3.1.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.98", "type": "external" } ], "go_molecular_function": "GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0006457 protein folding;GO:0034976 response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P54399-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54622-1", "uniprot_id": [ { "id": "SSBP_DROME", "url": "https://www.uniprot.org/uniprot/P54622", "type": "external" } ], "mass": 16368.0, "length": 146, "protein_name": "Single-stranded DNA-binding protein, mitochondrial", "gene_name": "mtSSB", "organism": "Fruit fly", "refseq_name": "mitochondrial single stranded DNA-binding protein", "refseq_ac": [ { "id": "NP_536744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536744", "type": "external" } ], "gene_names_uniprotkb": "mtSSB; CG4337; lopo", "gene_names_refseq": "0046/13; CG4337; Dmel\\CG4337; DmmtSSB; SSB_DROME; SSB; c3a; dmtSSB; lopo; mtSSB", "protein_names_uniprotkb": "Single-stranded DNA-binding protein, mitochondrial; Dm mtSSB; Mt-SSB; MtSSB; Protein low power", "protein_names_refseq": "CG4337-PA; low power; mitochondrial single strand binding protein; mitochondrial single stranded DNA-binding protein; mitochondrial single-stranded DNA-binding protein; mtSSB-PA", "tax_id": 7227, "disease": "optic atrophy (Disease Ontology:DOID:5723)", "pathway": " (dme:Dmel_CG4337); (R-DME-9837999); (R-DME-9913635)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10731132;10788480;11294889;12537572;14754882;21953457;26446790;28318978;7673145;8206370", "class_list": "", "function": "Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA) (PubMed:21953457, PubMed:7673145, PubMed:8206370). Required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the gamma complex polymerase PolG1/tam at the replication fork (PubMed:11294889, PubMed:14754882, PubMed:21953457, PubMed:26446790, PubMed:28318978, PubMed:7673145). Promotes PolG1 activity largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate PolG1 activity (PubMed:21953457, PubMed:26446790, PubMed:7673145)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5U164;Q9V3U4", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0042645 mitochondrial nucleoid;GO:0000262 mitochondrial chromosome", "go_biological_process": "GO:0090297 positive regulation of mitochondrial DNA replication;GO:0006260 DNA replication;GO:1900264 positive regulation of DNA-directed DNA polymerase activity;GO:0006264 mitochondrial DNA replication;GO:0090592 DNA synthesis involved in DNA replication", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P54622-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55828-1", "uniprot_id": [ { "id": "RS20_DROME", "url": "https://www.uniprot.org/uniprot/P55828", "type": "external" } ], "mass": 13488.0, "length": 120, "protein_name": "Small ribosomal subunit protein uS10", "gene_name": "RpS20", "organism": "Fruit fly", "refseq_name": "ribosomal protein S20", "refseq_ac": [ { "id": "NP_524421", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524421", "type": "external" } ], "gene_names_uniprotkb": "RpS20; CG15693", "gene_names_refseq": "CG15693; Dmel\\CG15693; RpS20; Rps20; S10; anon-EST:Posey111; anon-EST:Posey122; anon-EST:Posey147; rps20", "protein_names_uniprotkb": "Small ribosomal subunit protein uS10; 40S ribosomal protein S20", "protein_names_refseq": "CG15693-PA; RpS20-PA; ribosomal protein S20", "tax_id": 7227, "disease": "Diamond-Blackfan anemia (Disease Ontology:DOID:1339)", "pathway": " (dme:Dmel_CG15693); (R-DME-156827); (R-DME-1799339); (R-DME-72649); (R-DME-72689); (R-DME-72695); (R-DME-72702); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 12, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;18327897;23636399;9373141", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SYS0;Q9VDI4", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022626 cytosolic ribosome;GO:0015935 small ribosomal subunit;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0006412 translation;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P55828-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55830-1", "uniprot_id": [ { "id": "RS3A_DROME", "url": "https://www.uniprot.org/uniprot/P55830", "type": "external" } ], "mass": 30340.0, "length": 268, "protein_name": "Small ribosomal subunit protein eS1", "gene_name": "RpS3A", "organism": "Fruit fly", "refseq_name": "ribosomal protein S3A, isoform F", "refseq_ac": [ { "id": "NP_001245404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245404", "type": "external" } ], "gene_names_uniprotkb": "RpS3A; C3; CG2168; M(4)101", "gene_names_refseq": "C3; CG2168; Dmel\\CG2168; M(4)101; M(4)57g; M(4)[57g]; M57g; M[57g]; RPS3A; RPS3a; RpS3A; RpS3a; Rps3A; Rsp3A; S1e; anon-EST:Liang-2.29; chr4:86830..87021; chr4:87101..87234; chr4:87503..87595; clone 2.29; l(4)102ABa", "protein_names_uniprotkb": "Small ribosomal subunit protein eS1; 40S ribosomal protein S3a; C3 protein", "protein_names_refseq": "CG2168-PF; Minute(4)101; RpS3A-PF; clone 3; ribosomal protein S3A, isoform F; ribosomal protein S3alpha; ribosomal protein S3a", "tax_id": 7227, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)", "pathway": " (dme:Dmel_CG2168); (R-DME-156827); (R-DME-1799339); (R-DME-6791226); (R-DME-72649); (R-DME-72689); (R-DME-72695); (R-DME-72702); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 13, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;23636399;9393444;9742251", "class_list": "", "function": "Essential for oogenesis; required for late follicle cell development., [UniProtKB, PubMed, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C4IXY1;E4NKK4;H0RNB6;H9XVL9;O44389;Q8IMA9;Q8IMB0;Q8SZD2;Q9V4A9", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022626 cytosolic ribosome;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0006412 translation;GO:0048477 oogenesis;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P55830-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55935-1", "uniprot_id": [ { "id": "RS9_DROME", "url": "https://www.uniprot.org/uniprot/P55935", "type": "external" } ], "mass": 22623.0, "length": 195, "protein_name": "Small ribosomal subunit protein uS4", "gene_name": "RpS9", "organism": "Fruit fly", "refseq_name": "ribosomal protein S9, isoform E", "refseq_ac": [ { "id": "NP_001287008", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287008", "type": "external" } ], "gene_names_uniprotkb": "RpS9; CG3395", "gene_names_refseq": "CG3395; Dmel\\CG3395; RPS9; Rp S9; RpL11; RpS9; S4; S9; chr3L:9483841..9483937; chr3L:9484246..9484474", "protein_names_uniprotkb": "Small ribosomal subunit protein uS4; 40S ribosomal protein S9", "protein_names_refseq": "CG3395-PE; RpS9-PE; ribosomal protein S9, isoform E", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3395); (R-DME-156827); (R-DME-1799339); (R-DME-6791226); (R-DME-72649); (R-DME-72689); (R-DME-72695); (R-DME-72702); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 13, "publication_count": 4, "publication_id_list": "10731132;12537572;23636399;8400363", "class_list": "", "function": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4V1R4;Q6XIN2;Q9VT06;Q9VT07;Q9XZU5", "ec_number_list": [], "go_molecular_function": "GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022626 cytosolic ribosome;GO:0032040 small-subunit processome", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P55935-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56175-1", "uniprot_id": [ { "id": "RCL1_DROME", "url": "https://www.uniprot.org/uniprot/P56175", "type": "external" } ], "mass": 42091.0, "length": 384, "protein_name": "Probable RNA 3'-terminal phosphate cyclase-like protein", "gene_name": "Rtc1", "organism": "Fruit fly", "refseq_name": "Rtc1", "refseq_ac": [ { "id": "NP_572919", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572919", "type": "external" } ], "gene_names_uniprotkb": "Rtc1; CG11130; RCL1; RTC2", "gene_names_refseq": "CG11130; Dmel\\CG11130; Rtc1", "protein_names_uniprotkb": "Probable RNA 3'-terminal phosphate cyclase-like protein", "protein_names_refseq": "CG11130-PA; Rtc1-PA; Rtc1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11130); (R-DME-6791226)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;3029679;3114046;9184239", "class_list": "", "function": "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). Does not have cyclase activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95TH8;Q9VY90", "ec_number_list": [], "go_molecular_function": "GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0032040 small-subunit processome", "go_biological_process": "GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P56175-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58953-1", "uniprot_id": [ { "id": "GR22E_DROME", "url": "https://www.uniprot.org/uniprot/P58953", "type": "external" } ], "mass": 45560.0, "length": 389, "protein_name": "Gustatory receptor for bitter taste 22e", "gene_name": "Gr22e", "organism": "Fruit fly", "refseq_name": "gustatory receptor 22e", "refseq_ac": [ { "id": "NP_722731", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_722731", "type": "external" } ], "gene_names_uniprotkb": "Gr22e; CG31936", "gene_names_refseq": "CG31936; Dmel\\CG31936; GR22e; Gr22e; Gr2940.1", "protein_names_uniprotkb": "Gustatory receptor for bitter taste 22e", "protein_names_refseq": "CG31936-PA; Gr22e-PA; gustatory receptor 22e; gustatory receptor 2940.1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31936)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;11516643;12537572;12971900;18067151;22031876", "class_list": "", "function": "Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Seems to be involved in the sensing of bitter taste since it is expressed in neurons that mediate sensitivity to bitter compounds which are also avoidance-type taste neurons., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0008527 taste receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007165 signal transduction;GO:0034220 monoatomic ion transmembrane transport;GO:0050909 sensory perception of taste", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P58953-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58955-1", "uniprot_id": [ { "id": "GR36A_DROME", "url": "https://www.uniprot.org/uniprot/P58955", "type": "external" } ], "mass": 45373.0, "length": 391, "protein_name": "Putative gustatory receptor 36a", "gene_name": "Gr36a", "organism": "Fruit fly", "refseq_name": "gustatory receptor 36a", "refseq_ac": [ { "id": "NP_724038", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_724038", "type": "external" } ], "gene_names_uniprotkb": "Gr36a; CG31747", "gene_names_refseq": "CG31747; Dmel\\CG31747; GR36a; GRLU.1; Gr36B1; Gr36a; GrLU1; LU.1", "protein_names_uniprotkb": "Putative gustatory receptor 36a", "protein_names_refseq": "CG31747-PA; Gr36a-PA; gustatory receptor 36a; gustatory receptor LU.1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31747)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;11516643;12537572", "class_list": "", "function": "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8INZ3", "ec_number_list": [], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0008527 taste receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007165 signal transduction;GO:0034220 monoatomic ion transmembrane transport;GO:0050909 sensory perception of taste", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P58955-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58985-1", "uniprot_id": [ { "id": "GR59D_DROME", "url": "https://www.uniprot.org/uniprot/P58985", "type": "external" } ], "mass": 44823.0, "length": 390, "protein_name": "Putative gustatory receptor 59d", "gene_name": "Gr59d", "organism": "Fruit fly", "refseq_name": "gustatory receptor 59d", "refseq_ac": [ { "id": "NP_611758", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611758", "type": "external" } ], "gene_names_uniprotkb": "Gr59d; CG30330; GR59D.1", "gene_names_refseq": "59D.1; 59D1; CG13543; CG30330; Dmel\\CG30330; GR59D.1; GR59d; Gr59D1; Gr59d", "protein_names_uniprotkb": "Putative gustatory receptor 59d", "protein_names_refseq": "CG30330-PA; Gr59d-PA; gustatory receptor 59D.1; gustatory receptor 59d", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG30330)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10710312;10731132;11516643;12537572;22031876", "class_list": "", "function": "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0008527 taste receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007165 signal transduction;GO:0034220 monoatomic ion transmembrane transport;GO:0050909 sensory perception of taste", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P58985-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61851-1", "uniprot_id": [ { "id": "SODC_DROME", "url": "https://www.uniprot.org/uniprot/P61851", "type": "external" } ], "mass": 15699.0, "length": 153, "protein_name": "Superoxide dismutase [Cu-Zn]", "gene_name": "Sod1", "organism": "Fruit fly", "refseq_name": "superoxide dismutase 1", "refseq_ac": [ { "id": "NP_476735", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476735", "type": "external" } ], "gene_names_uniprotkb": "Sod1; CG11793; Sod", "gene_names_refseq": "24492; CG11793; Cu-Zn SOD; Cu-Zn-SOD; Cu/Zn SOD; Cu/Zn Sod; Cu/Zn sod; Cu/Zn superoxide dismutase; Cu/Zn-SOD; Cu/ZnSOD; CuSOD; CuZn SOD; CuZn-SOD1; CuZn-SOD; CuZnSOD; Cu[2+]/Zn[2+]SOD; Cu; Dmel\\CG11793; G; Mn SOD; SOD-1; SOD-c; SOD1; SODC_DROME; SOD; Sod-1; Sod1; Sod; To-1; To; ZN-SOD; Zn SOD; Zn Sod; Zn-SOD1; Zn-SOD; ZnSod; cSOD; cSod; dSOD1; dSod1; dsod1; dsod; l(3)108; l(3)68Af'; l(3)G; sod-1; sod1; sod", "protein_names_uniprotkb": "Superoxide dismutase [Cu-Zn]; 1.15.1.1; Superoxide dismutase 1", "protein_names_refseq": "CG11793-PA; Cu, Zn superoxide dismutase; Cu-Zn superoxide dismutase; Cu/Zn superoxide dismutase; Cu/Zn-Superoxide dismutase; CuZn superoxide dismutase; CuZn-superoxide dismutase (SOD)1; CuZnSOD; Cu[2+] Zn[2+] superoxide dismutase; Cu[2+]Zn[2+] superoxide dismutase; Mn superoxide dismutase; SOD 1; Sod1-PA; complementation group G; copper and zinc SOD; copper-zinc superoxide dismutase; copper-zinc superoxide; cytoplasmic Cu/ZnSOD; super oxide dismutase; superoxidase dismutase; superoxide dismutase 1; superoxide dismutases 1; superoxide dismutatase; superoxide-dismutase; superoxido dismutase; tetrazolium oxidase-1; tetrazolium oxidase", "tax_id": 7227, "disease": "amyotrophic lateral sclerosis type 1 (Disease Ontology:DOID:0060193); atrial fibrillation (Disease Ontology:DOID:0060224); alcohol-associated liver disease (Disease Ontology:DOID:0070658); polycystic kidney disease (Disease Ontology:DOID:0080322); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); dry eye syndrome (Disease Ontology:DOID:10140); retinitis pigmentosa (Disease Ontology:DOID:10584); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); diabetic angiopathy (Disease Ontology:DOID:11713); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); retinopathy of prematurity (Disease Ontology:DOID:13025); Behcet's disease (Disease Ontology:DOID:13241); low tension glaucoma (Disease Ontology:DOID:13544); Down syndrome (Disease Ontology:DOID:14250); Parkinson's disease (Disease Ontology:DOID:14330); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); cystitis (Disease Ontology:DOID:1679); pancreatic cancer (Disease Ontology:DOID:1793); transient cerebral ischemia (Disease Ontology:DOID:224); motor neuron disease (Disease Ontology:DOID:231); renal artery obstruction (Disease Ontology:DOID:2972); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); hyperglycemia (Disease Ontology:DOID:4195); macular degeneration (Disease Ontology:DOID:4448); nutritional deficiency disease (Disease Ontology:DOID:5113); myocardial infarction (Disease Ontology:DOID:5844); prion disease (Disease Ontology:DOID:649); progressive supranuclear palsy (Disease Ontology:DOID:678); hyperthyroidism (Disease Ontology:DOID:7998); cataract (Disease Ontology:DOID:83); diabetic retinopathy (Disease Ontology:DOID:8947); cutaneous leishmaniasis (Disease Ontology:DOID:9111); ocular hypertension (Disease Ontology:DOID:9282); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dme:Dmel_CG11793)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537569;12537572;15952742;17372656;18948262;2470654;2493630;3110743;3122185;3128462;3919383;3929689;8013910", "class_list": "", "function": "Destroys radicals which are normally produced within the cells and which are toxic to biological systems., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 41, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P00444;Q27770;Q9VTF6", "ec_number_list": [ { "id": "1.15.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005507 copper ion binding;GO:0004784 superoxide dismutase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005758 mitochondrial intermembrane space;GO:0005777 peroxisome", "go_biological_process": "GO:1901526 positive regulation of mitophagy;GO:0006979 response to oxidative stress;GO:0048167 regulation of synaptic plasticity;GO:0019430 removal of superoxide radicals;GO:0008340 determination of adult lifespan", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P61851-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80455-1", "uniprot_id": [ { "id": "RS12_DROME", "url": "https://www.uniprot.org/uniprot/P80455", "type": "external" } ], "mass": 15169.0, "length": 139, "protein_name": "Small ribosomal subunit protein eS12", "gene_name": "RpS12", "organism": "Fruit fly", "refseq_name": "ribosomal protein S12", "refseq_ac": [ { "id": "NP_729866", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_729866", "type": "external" } ], "gene_names_uniprotkb": "RpS12; CG11271; RpS12E", "gene_names_refseq": "BcDNA:RH29995; CG11271; Dmel\\CG11271; RS12; RpS12E; RpS12; S12e; S12; dRpS12; l(3)s2783; rpS12; su(comp)3L-1", "protein_names_uniprotkb": "Small ribosomal subunit protein eS12; 40S ribosomal protein S12", "protein_names_refseq": "40S ribosomal component; 40S ribosomal protein S12; CG11271-PB; RpS12-PB; minute; ribosomal protein S12e; ribosomal protein S12; ribosomal protein gene 12", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11271); (R-DME-156827); (R-DME-1799339); (R-DME-72649); (R-DME-72689); (R-DME-72695); (R-DME-72702); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 12, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;23636399;31841522", "class_list": "", "function": "Subunit of the 40S ribosomal complex (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). In wing imaginal disks, might have a role in translation rate, growth and cell competition, probably through regulation of Xrp1 expression (PubMed:31841522). Might have a role in development and longevity (PubMed:31841522)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0E8F1;Q9VU40", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022626 cytosolic ribosome;GO:0015935 small ribosomal subunit;GO:0032040 small-subunit processome;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:1990145 maintenance of translational fidelity;GO:0002181 cytoplasmic translation;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P80455-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81910-1", "uniprot_id": [ { "id": "OR22B_DROME", "url": "https://www.uniprot.org/uniprot/P81910", "type": "external" } ], "mass": 46402.0, "length": 397, "protein_name": "Odorant receptor 22b", "gene_name": "Or22b", "organism": "Fruit fly", "refseq_name": "odorant receptor 22b", "refseq_ac": [ { "id": "NP_477425", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477425", "type": "external" } ], "gene_names_uniprotkb": "Or22b; AN12; CG4231; DOR22A.2; Or22A.2; dor67", "gene_names_refseq": "22A.2; 22b; AN12; CG4231; DOR22A.2; DOR22b; DOR67; Dmel\\CG4231; Dor67; OR22b; Or22A.2; Or22a/b; Or22b; Or22; Or67; dOr22b; dor67; or22b", "protein_names_uniprotkb": "Odorant receptor 22b", "protein_names_refseq": "CG4231-PA; Or22b-PA; dmel Or22b; odorant receptor 22b; odorant receptor 67; olfactory receptor 22A.2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4231)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10069338;10089887;10458908;10731132;10943836;12537572;12628173;16402857;18922763;22038943", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Involved in the behavioral responses to esters. Complexes with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. They are necessary and sufficient to promote functional reconstitution of odor-evoked signaling in sensory neurons that normally respond only to carbon dioxide., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7VC06;B7VC10;B7VC50;B7VC52;B7VC62;B7VC68;B7VC76;B7VC81;B7VC83;B7VC85;B7VC86;B7VC87;B7VC91;B7VC99;B7VCA1;B7VCA6;Q9U6X6;Q9VQ19", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P81910-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81911-1", "uniprot_id": [ { "id": "OR22C_DROME", "url": "https://www.uniprot.org/uniprot/P81911", "type": "external" } ], "mass": 44874.0, "length": 402, "protein_name": "Odorant receptor 22c", "gene_name": "Or22c", "organism": "Fruit fly", "refseq_name": "odorant receptor 22c", "refseq_ac": [ { "id": "NP_523454", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523454", "type": "external" } ], "gene_names_uniprotkb": "Or22c; CG15377; DOR22C.1; Or22C.1", "gene_names_refseq": "22C.1; 22c; CG15377; DOR16; DOR22C.1; Dmel\\CG15377; Or22C.1; Or22c", "protein_names_uniprotkb": "Odorant receptor 22c", "protein_names_refseq": "CG15377-PA; Or22c-PA; odorant receptor 22c; olfactory receptor 22C.1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15377)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10069338;10731132;12537572;21613503", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VQ70", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P81911-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81912-1", "uniprot_id": [ { "id": "OR23A_DROME", "url": "https://www.uniprot.org/uniprot/P81912", "type": "external" } ], "mass": 43793.0, "length": 379, "protein_name": "Odorant receptor 23a", "gene_name": "Or23a", "organism": "Fruit fly", "refseq_name": "odorant receptor 23a", "refseq_ac": [ { "id": "NP_523458", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523458", "type": "external" } ], "gene_names_uniprotkb": "Or23a; AN5; CG9880; DOR23A.1; Or23A.1; dor64", "gene_names_refseq": "23A.1; 23a; AN5; CG9880; DOR23A.1; DOR64; Dmel\\CG9880; Dor64; OR23a; Or23A.1; Or23a; Or64; dor64; or23a", "protein_names_uniprotkb": "Odorant receptor 23a", "protein_names_refseq": "CG9880-PA; Or23a-PA; odorant receptor 23a; odorant receptor 64; olfactory receptor 23A.1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9880)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10069338;10089887;10458908;10731132;10943836;12537572;16615896", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P81912-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81915-1", "uniprot_id": [ { "id": "OR33B_DROME", "url": "https://www.uniprot.org/uniprot/P81915", "type": "external" } ], "mass": 43633.0, "length": 379, "protein_name": "Odorant receptor 33b", "gene_name": "Or33b", "organism": "Fruit fly", "refseq_name": "odorant receptor 33b", "refseq_ac": [ { "id": "NP_523554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523554", "type": "external" } ], "gene_names_uniprotkb": "Or33b; AN1; CG16961; DOR33B.2; Or33B.2; dor72", "gene_names_refseq": "33B.2; 33b; AN1; CG16961; DOR33B.2; DOR72; Dmel\\CG16961; OR33b; Or33B.2; Or33b; Or72; dor72", "protein_names_uniprotkb": "Odorant receptor 33b", "protein_names_refseq": "CG16961-PA; Or33b-PA; odorant receptor 33b; olfactory receptor 33B.2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG16961)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10069338;10089887;10458908;10731132;10943836;12537572;16615896;20577637;21613503;21857978", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to pentyl acetate and pyrazines., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P81915-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81917-1", "uniprot_id": [ { "id": "OR43A_DROME", "url": "https://www.uniprot.org/uniprot/P81917", "type": "external" } ], "mass": 43090.0, "length": 376, "protein_name": "Odorant receptor 43a", "gene_name": "Or43a", "organism": "Fruit fly", "refseq_name": "odorant receptor 43a", "refseq_ac": [ { "id": "NP_523647", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523647", "type": "external" } ], "gene_names_uniprotkb": "Or43a; AN14; CG1854; DOR43B.1; Or43B.1; dor87", "gene_names_refseq": "43B.1; 43B1; 43a; AN14; CG1854; DOR43B.1; DOR43a; DOR87; Dmel\\CG1854; Dor87; OR43a; Or43A; Or43B.1; Or43a; Or87; Or; dor87; or43a", "protein_names_uniprotkb": "Odorant receptor 43a", "protein_names_refseq": "CG1854-PA; Or43a-PA; odorant receptor 43a; odorant receptor 87; olfactory receptor 43B.1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1854)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10069338;10089887;10458908;10731132;10943836;11481494;11481495;12537572;15647466;16402857;16615896;20628035", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Complexes with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. They are necessary and sufficient to promote functional reconstitution of odor-evoked signaling in sensory neurons that normally respond only to carbon dioxide. Involved in the behavioral responses to acetophenone, benzaldehyde, benzyl alcohol, cyclohexanone, and cyclohexanol., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9U6X4;Q9V4J0", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P81917-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V3N2-1", "uniprot_id": [ { "id": "OR46B_DROME", "url": "https://www.uniprot.org/uniprot/Q9V3N2", "type": "external" } ], "mass": 44451.0, "length": 384, "protein_name": "Odorant receptor 46a, isoform B", "gene_name": "Or46a", "organism": "Fruit fly", "refseq_name": "odorant receptor 46a, isoform B", "refseq_ac": [ { "id": "NP_995793", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_995793", "type": "external" } ], "gene_names_uniprotkb": "Or46a; AN8; AN9; CG33478; DOR46F.1; DOR46F; OR46F; Or46F.1; Or46F.2; Or46b; dor19", "gene_names_refseq": "46F.1; 46a; 46b; AN8; AN9; CG17848; CG17849; CG33478; DOR19; DOR20; DOR46F.1; DOR46F.2; DmelOR46a; Dmel\\CG33478; OR46a; Or19; Or46B; Or46F.1; Or46F.2; Or46aA; Or46aB; Or46aa; Or46a; Or46b; dor19", "protein_names_uniprotkb": "Odorant receptor 46a, isoform B", "protein_names_refseq": "CG33478-PB; Or46a-PB; odorant receptor 46a, isoform B; odorant receptor 46b; olfactory receptor 46F.1; olfactory receptor 46F.2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33478)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10069338;10089887;10458908;10731132;10943836;12537572;14608037", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P81920", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9V3N2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81921-1", "uniprot_id": [ { "id": "OR47A_DROME", "url": "https://www.uniprot.org/uniprot/P81921", "type": "external" } ], "mass": 43966.0, "length": 385, "protein_name": "Odorant receptor 47a", "gene_name": "Or47a", "organism": "Fruit fly", "refseq_name": "odorant receptor 47a", "refseq_ac": [ { "id": "NP_523689", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523689", "type": "external" } ], "gene_names_uniprotkb": "Or47a; AN10; CG13225; DOR47E.1; Or47E.1; dor24", "gene_names_refseq": "47E.1; 47a; AN10; CG13225; DOR24; DOR47E.1; Dmel\\CG13225; OR47a; Or24; Or47E.1; Or47a; dor24; or47a", "protein_names_uniprotkb": "Odorant receptor 47a", "protein_names_refseq": "CG13225-PA; Or47a-PA; odorant receptor 47a; olfactory receptor 47E.1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13225)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10069338;10089887;10458908;10731132;10943836;12537572;16402857;16615896;18408711;18408712;21613503;21857978;22038943", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Complexes with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. They are necessary and sufficient to promote functional reconstitution of odor-evoked signaling in sensory neurons that normally respond only to carbon dioxide. Involved in the behavioral responses to esters. Involved in the behavioral responses to pentyl acetate., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9U6X8", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P81921-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81922-1", "uniprot_id": [ { "id": "OR47B_DROME", "url": "https://www.uniprot.org/uniprot/P81922", "type": "external" } ], "mass": 47913.0, "length": 412, "protein_name": "Odorant receptor 47b", "gene_name": "Or47b", "organism": "Fruit fly", "refseq_name": "odorant receptor 47b", "refseq_ac": [ { "id": "NP_523690", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523690", "type": "external" } ], "gene_names_uniprotkb": "Or47b; CG13206; DOR47E.2; Or47E.2", "gene_names_refseq": "47E.2; 47b; CG13206; DOR25; DOR47E.2; DmOr47b; Dmel\\CG13206; OR 47b; OR47b; Or47E.2; Or47b; or47b", "protein_names_uniprotkb": "Odorant receptor 47b", "protein_names_refseq": "CG13206-PA; Or47b-PA; odorant receptor 47b; olfactory receptor 47E.2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13206)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10069338;10731132;10943836;12537572;16615896;21516101;22476771;23652013;25964351;27263969;27278650", "class_list": "", "function": "Odorant receptor for female pheromones, such as palmitoleic acid (PA) and methyl-laurate, which is involved in male courtship (PubMed:16615896, PubMed:21516101, PubMed:25964351, PubMed:27263969). Forms a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (PubMed:16615896, PubMed:21516101). Plays an important role in male courtship in a pheromone-dependent manner: acts as a receptor for female pheromones, such as palmitoleic acid (PA) and methyl-laurate, activating an olfactory circuit that promotes male courtship (PubMed:22476771, PubMed:23652013). Mediates the copulation advantage of older males over young males (PubMed:25964351, PubMed:27263969). Older males are more sensitive to female pheromones in comparison with younger males: age-dependent modulation of Or47b olfactory receptor neurons sensitivity is controlled by the juvenile hormone via Methoprene-tolerant receptor Met (PubMed:25964351, PubMed:27263969). Also mediates males' preference for younger females: Or47b is required for males to discriminate younger female mates from older ones (PubMed:27278650)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9V5X4", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007608 sensory perception of smell;GO:0019236 response to pheromone;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P81922-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82891-1", "uniprot_id": [ { "id": "PPAC2_DROME", "url": "https://www.uniprot.org/uniprot/P82891", "type": "external" } ], "mass": 18541.0, "length": 164, "protein_name": "Low molecular weight phosphotyrosine protein phosphatase 2", "gene_name": "primo-2", "organism": "Fruit fly", "refseq_name": "primo-2", "refseq_ac": [ { "id": "NP_001027188", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027188", "type": "external" } ], "gene_names_uniprotkb": "primo-2; CG31311", "gene_names_refseq": "BEO2; CG31311; CG33747; CG9599; Dmel\\CG33747; LMW-PTP; Primo-2; primo-2; primo", "protein_names_uniprotkb": "Low molecular weight phosphotyrosine protein phosphatase 2; 3.1.3.2; 3.1.3.48; Low molecular weight cytosolic acid phosphatase 2; PTPase 2", "protein_names_refseq": "CG33747-PC; primo-2-PC; primo-2", "tax_id": 7227, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); conduct disorder (Disease Ontology:DOID:12995); coronary artery disease (Disease Ontology:DOID:3393); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG33747)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10675607;10731132;12537569;12537572", "class_list": "", "function": "Catalyzes the dephosphorylation of tyrosine phosphorylated proteins and low-MW aryl phosphates (PubMed:10675607). Can contribute to the regulation of a variety of developmental processes (PubMed:10675607)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0KI75;Q9VFR9", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" } ], "go_molecular_function": "GO:0003993 acid phosphatase activity;GO:0004726 non-membrane spanning protein tyrosine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P82891-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82985-1", "uniprot_id": [ { "id": "OR69B_DROME", "url": "https://www.uniprot.org/uniprot/P82985", "type": "external" } ], "mass": 46096.0, "length": 393, "protein_name": "Putative odorant receptor 69a, isoform B", "gene_name": "Or69a", "organism": "Fruit fly", "refseq_name": "odorant receptor 69a, isoform B", "refseq_ac": [ { "id": "NP_996069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996069", "type": "external" } ], "gene_names_uniprotkb": "Or69a; CG32116; Or69b", "gene_names_refseq": "69F.1; 69a; 69b; CG17902; CG32116; CG33264; DOR82; DOR83; DmOr69a; Dmel\\CG33264; OR69a; Or69A; Or69aA; Or69aB; Or69ab; Or69a; Or69b; or69a", "protein_names_uniprotkb": "Putative odorant receptor 69a, isoform B", "protein_names_refseq": "CG33264-PB; Or69a-PB; odorant receptor 69a, isoform B; odorant receptor 69b", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33264)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;10943836;12537572;14608037", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P82985-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82986-1", "uniprot_id": [ { "id": "OR82A_DROME", "url": "https://www.uniprot.org/uniprot/P82986", "type": "external" } ], "mass": 43635.0, "length": 385, "protein_name": "Odorant receptor 82a", "gene_name": "Or82a", "organism": "Fruit fly", "refseq_name": "odorant receptor 82a", "refseq_ac": [ { "id": "NP_730794", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_730794", "type": "external" } ], "gene_names_uniprotkb": "Or82a; CG31519", "gene_names_refseq": "82a; CG31519; DOR61; DmOR82A; DmOr82a; Dmel\\CG31519; OR82a; Or82a", "protein_names_uniprotkb": "Odorant receptor 82a", "protein_names_refseq": "CG31519-PA; Or82a-PA; odorant receptor 82a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31519)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;10943836;12537572;16615896;21613503", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007320 insemination;GO:0007165 signal transduction;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P82986-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83101-1", "uniprot_id": [ { "id": "GSK3H_DROME", "url": "https://www.uniprot.org/uniprot/P83101", "type": "external" } ], "mass": 56237.0, "length": 501, "protein_name": "Putative glycogen synthase kinase-3 homolog", "gene_name": "gskt", "organism": "Fruit fly", "refseq_name": "gasket", "refseq_ac": [ { "id": "NP_733426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_733426", "type": "external" } ], "gene_names_uniprotkb": "gskt; CG31003", "gene_names_refseq": "BEST:GH16447; BcDNA:AT21229; CG11338; CG31003; CT4237; Dm Gskt; Dmel\\CG31003; GSK-3b; GSK3b; Gsk3b; Gskt; NEST:bs22e06; NGSK; SINA; gskt; mjl", "protein_names_uniprotkb": "Putative glycogen synthase kinase-3 homolog; 2.7.11.26; GSK-3; Protein gasket", "protein_names_refseq": "CG31003-PA; gasket; gskt-PA; mojoless", "tax_id": 7227, "disease": "diabetic encephalopathy (Disease Ontology:DOID:0050850); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); Parkinsonism (Disease Ontology:DOID:0080855); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); sciatic neuropathy (Disease Ontology:DOID:11446); Parkinson's disease (Disease Ontology:DOID:14330); depressive disorder (Disease Ontology:DOID:1596); status epilepticus (Disease Ontology:DOID:1824); colon cancer (Disease Ontology:DOID:219); endometrial carcinoma (Disease Ontology:DOID:2871); substance-related disorder (Disease Ontology:DOID:303); bipolar disorder (Disease Ontology:DOID:3312); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); middle cerebral artery infarction (Disease Ontology:DOID:3525); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); vascular dementia (Disease Ontology:DOID:8725); degenerative disc disease (Disease Ontology:DOID:90); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (dme:Dmel_CG31003); (R-DME-195253); (R-DME-196299); (R-DME-3371453); (R-DME-4641262); (R-DME-5610785); (R-DME-69601); (R-DME-9762114); (R-DME-9856649)", "pathway_count": 9, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 23, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "5.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.5", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0050321 tau-protein kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0048232 male gamete generation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P83101-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83104-1", "uniprot_id": [ { "id": "M3K7L_DROME", "url": "https://www.uniprot.org/uniprot/P83104", "type": "external" } ], "mass": 45239.0, "length": 393, "protein_name": "Putative mitogen-activated protein kinase kinase kinase 7-like", "gene_name": "Takl1", "organism": "Fruit fly", "refseq_name": "Tak1-like 1", "refseq_ac": [ { "id": "NP_732554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_732554", "type": "external" } ], "gene_names_uniprotkb": "Takl1; CG31421", "gene_names_refseq": "CG31421; Dmel\\CG31421; FBgn0046689; TAKL1; Takl1; anon-AE003732.1; takl1", "protein_names_uniprotkb": "Putative mitogen-activated protein kinase kinase kinase 7-like; 2.7.11.25", "protein_names_refseq": "CG31421-PA; Tak1-like 1; Takl1-PA; extra2", "tax_id": 7227, "disease": "frontometaphyseal dysplasia (Disease Ontology:DOID:0111785); frontometaphyseal dysplasia 2 (Disease Ontology:DOID:0111787); prostate cancer (Disease Ontology:DOID:10283); benign hypertensive renal disease (Disease Ontology:DOID:11520); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); arteriosclerosis (Disease Ontology:DOID:2349); coronary artery disease (Disease Ontology:DOID:3393); Wolff-Parkinson-White syndrome (Disease Ontology:DOID:384); myocardial infarction (Disease Ontology:DOID:5844); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (dme:Dmel_CG31421)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V4Q1", "ec_number_list": [ { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "5.6.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.8", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006955 immune response;GO:0007254 JNK cascade;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0006950 response to stress", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P83104-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83119-1", "uniprot_id": [ { "id": "MTH12_DROME", "url": "https://www.uniprot.org/uniprot/P83119", "type": "external" } ], "mass": 56781.0, "length": 488, "protein_name": "Probable G protein-coupled receptor Mth-like 12", "gene_name": "mthl12", "organism": "Fruit fly", "refseq_name": "methuselah-like 12", "refseq_ac": [ { "id": "NP_731791", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_731791", "type": "external" } ], "gene_names_uniprotkb": "mthl12; CG32853; Mth-like-12", "gene_names_refseq": "CG32853; Dmel\\CG32853; Mthl12; mthl12", "protein_names_uniprotkb": "Probable G protein-coupled receptor Mth-like 12; Protein methuselah-like 12", "protein_names_refseq": "CG32853-PA; Mth-like 12; Mth-like-12; methuselah-like 12; mthl12-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32853)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;11274391;12537572", "class_list": "", "function": "", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8INH4", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008528 G protein-coupled peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0042594 response to starvation;GO:0008340 determination of adult lifespan", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P83119-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83740-1", "uniprot_id": [ { "id": "SC5A6_DROME", "url": "https://www.uniprot.org/uniprot/P83740", "type": "external" } ], "mass": 66587.0, "length": 604, "protein_name": "Putative sodium-dependent multivitamin transporter", "gene_name": "CG32669", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_727460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_727460", "type": "external" } ], "gene_names_uniprotkb": "CG32669", "gene_names_refseq": "CG32669; Dmel\\CG32669; dSLC5A4", "protein_names_uniprotkb": "Putative sodium-dependent multivitamin transporter; Na(+)-dependent multivitamin transporter", "protein_names_refseq": "CG32669-PA; uncharacterized protein", "tax_id": 7227, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); thyroid dyshormonogenesis 1 (Disease Ontology:DOID:0112185)", "pathway": " (dme:Dmel_CG32669)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5U123", "ec_number_list": [], "go_molecular_function": "GO:0015293 symporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P83740-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83949-1", "uniprot_id": [ { "id": "UBX_DROME", "url": "https://www.uniprot.org/uniprot/P83949", "type": "external" } ], "mass": 40040.0, "length": 389, "protein_name": "Homeotic protein ultrabithorax", "gene_name": "Ubx", "organism": "Fruit fly", "refseq_name": "ultrabithorax, isoform B", "refseq_ac": [ { "id": "NP_536748", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536748", "type": "external" } ], "gene_names_uniprotkb": "Ubx; CG10388", "gene_names_refseq": "BX-C; Bxl; CG10388; Cbx; DUbx; Dm Ubx; DmUbx; Dmel\\CG10388; Hm; Pbx; UBX; UBx; Uab; Ubx1b; Ubx[[Drosophila]]; Ubx; abx/bx; abx; bx[D]; bxd/pbx; bxd[D]; bxd; bxl; bx; l(3)89Eb; pbx; ubx", "protein_names_uniprotkb": "Homeotic protein ultrabithorax", "protein_names_refseq": "CG10388-PB; Ubx-PB; anterobithorax; bithorax complex; bithoraxoid; bithorax; contrabithorax; haltere mimic; postbithorax; ultabithorax; ultarbithorax; ultraabdominal; ultrabithorax, isoform B; ultrabithorax", "tax_id": 7227, "disease": "leukemia (Disease Ontology:DOID:1240)", "pathway": " (dme:Dmel_CG10388)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10067897;10731132;12537572;16453777;1673656;18327897;2565858;6327065;6330741;7667301;7911773;8098307", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds the consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02834;Q9TX83;Q9VER4;Q9VER5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0019904 protein domain specific binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0017053 transcription repressor complex;GO:0005667 transcription regulator complex;GO:0032993 protein-DNA complex;GO:0005704 polytene chromosome band", "go_biological_process": "GO:0007525 somatic muscle development;GO:0007501 mesodermal cell fate specification;GO:0010092 specification of animal organ identity;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P83949-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P91657-1", "uniprot_id": [ { "id": "OPS5_DROME", "url": "https://www.uniprot.org/uniprot/P91657", "type": "external" } ], "mass": 42705.0, "length": 382, "protein_name": "Opsin Rh5", "gene_name": "Rh5", "organism": "Fruit fly", "refseq_name": "rhodopsin 5, isoform B", "refseq_ac": [ { "id": "NP_001285859", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285859", "type": "external" } ], "gene_names_uniprotkb": "Rh5; CG5279; DMELRH5; Dm Rh5; Dmel\\CG5279; Dmel_CG5279; RH5; Rh; r5; rh5", "gene_names_refseq": "CG5279; DMELRH5; Dm Rh5; Dmel\\CG5279; RH5; Rh5; Rh; r5; rh5", "protein_names_uniprotkb": "Opsin Rh5", "protein_names_refseq": "CG5279-PB; Rh5-PB; Rhodopsin5; rhodopsin 5, isoform B; rhodopsin 5; rhodopsin-5; rhodopsin", "tax_id": 7227, "disease": "sensorineural hearing loss (Disease Ontology:DOID:10003)", "pathway": " (dme:Dmel_CG5279)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8982159;9165115", "class_list": "", "function": "Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P91671;Q9VKD1", "ec_number_list": [], "go_molecular_function": "GO:0008020 G protein-coupled photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016028 rhabdomere;GO:0033583 rhabdomere membrane", "go_biological_process": "GO:0016038 absorption of visible light;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007605 sensory perception of sound;GO:0009416 response to light stimulus", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P91657-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P91682-1", "uniprot_id": [ { "id": "SMO_DROME", "url": "https://www.uniprot.org/uniprot/P91682", "type": "external" } ], "mass": 116552.0, "length": 1036, "protein_name": "Protein smoothened", "gene_name": "smo", "organism": "Fruit fly", "refseq_name": "smoothened", "refseq_ac": [ { "id": "NP_523443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523443", "type": "external" } ], "gene_names_uniprotkb": "smo; CG11561", "gene_names_refseq": "CG11561; Dmel\\CG11561; SMO; Smo; dSmo; smo", "protein_names_uniprotkb": "Protein smoothened; SMOH; Smooth; dSMO", "protein_names_refseq": "CG11561-PA; smo-PA; smoothened; smoothene", "tax_id": 7227, "disease": "primary bacterial infectious disease (Disease Ontology:DOID:0050338); medulloblastoma (Disease Ontology:DOID:0050902); pre-malignant neoplasm (Disease Ontology:DOID:0060071); stomach cancer (Disease Ontology:DOID:10534); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); nevoid basal cell carcinoma syndrome (Disease Ontology:DOID:2512); basal cell carcinoma (Disease Ontology:DOID:2513); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); esophagus adenocarcinoma (Disease Ontology:DOID:4914); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); gastric papillary adenocarcinoma (Disease Ontology:DOID:5593); gastric tubular adenocarcinoma (Disease Ontology:DOID:6595); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); malignant pleural mesothelioma (Disease Ontology:DOID:7474); Barrett's esophagus (Disease Ontology:DOID:9206); colorectal cancer (Disease Ontology:DOID:9256); ocular hypertension (Disease Ontology:DOID:9282); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (dme:Dmel_CG11561); (R-DME-209214); (R-DME-209338); (R-DME-216119); (R-DME-216217); (R-DME-5610787); (R-DME-5620922); (R-DME-5635838)", "pathway_count": 8, "publication_count": 53, "publication_id_list": "10102270;10458606;10529426;10731132;10825151;10862738;10862750;10952898;10966113;11090136;11495917;11934882;11997517;12537572;12663920;14523402;14597665;14614827;14636583;15063184;15300262;15563523;15592457;15598741;15616566;15691767;15750186;15875013;16041759;16630821;17077139;17182028;17671093;17881487;17925225;17960137;18211840;18327897;18987629;22253574;24351982;24768000;25349414;25639794;8700230;8706127;8769644;8898207;8906787;8906794;9109493;9122207;9431812", "class_list": "", "function": "G protein-coupled receptor, which transduces the smoothened signaling pathway and which is required for correct patterning of every segment (PubMed:10966113, PubMed:15616566, PubMed:15691767, PubMed:8700230, PubMed:8706127). Activated by cholesterol in response to hedgehog (hh) morphogen (By similarity). In absence of hedgehog, smo is inactivated by patched protein (ptc), which prevents smo access to cholesterol (By similarity). In response to hh-binding to ptc, inhibition is relieved, promoting smo translocation to primary cilium and activation by cholesterol: cholesterol causes a conformation change that triggers signaling via G protein G(i), mediating inhibition of adenylate cyclase activity and decreassed production of cAMP (By similarity). Essential component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required to activate Cad99C-dependent endosome formation, norpA-dependent Ca2+ mobilization and p38 MAPK, which are essential steps in the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "B7FNK1;Q9VPM8", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0070273 phosphatidylinositol-4-phosphate binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0010628 positive regulation of gene expression;GO:0007417 central nervous system development;GO:0007346 regulation of mitotic cell cycle;GO:1903078 positive regulation of protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 5.4, "record_id": "P91682-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P91875-1", "uniprot_id": [ { "id": "RPA1_DROME", "url": "https://www.uniprot.org/uniprot/P91875", "type": "external" } ], "mass": 185410.0, "length": 1642, "protein_name": "DNA-directed RNA polymerase I subunit A", "gene_name": "PolR1A", "organism": "Fruit fly", "refseq_name": "RNA polymerase I subunit A", "refseq_ac": [ { "id": "NP_523743", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523743", "type": "external" } ], "gene_names_uniprotkb": "PolR1A; CG10122; RPA1; Rpl1", "gene_names_refseq": "153129_at; CG10122; DmRPA1; Dmel\\CG10122; Polr1A; RPA190; RPA1; RpI1; Rpl1", "protein_names_uniprotkb": "DNA-directed RNA polymerase I subunit A; 2.7.7.6; DNA-directed RNA polymerase I largest subunit; RNA polymerase I subunit A1", "protein_names_refseq": "CG10122-PA; Polr1A-PA; RNA polymerase I subunit A; RNA polymerase I subunit; RNA polymerase I", "tax_id": 7227, "disease": "acrofacial dysostosis Cincinnati type (Disease Ontology:DOID:0060353); hypomyelinating leukodystrophy (Disease Ontology:DOID:0060786)", "pathway": " (dme:Dmel_CG10122); (R-DME-73762); (R-DME-73772)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;18327897;32049000;9065685", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:32049000). Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors (PubMed:32049000). Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). Involved in determining adult lifespan and aging (PubMed:32049000)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8MRE2;Q9V732", "ec_number_list": [ { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005736 RNA polymerase I complex", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0006362 transcription elongation by RNA polymerase I;GO:0008340 determination of adult lifespan;GO:0006361 transcription initiation at RNA polymerase I promoter;GO:0042790 nucleolar large rRNA transcription by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P91875-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P91927-1", "uniprot_id": [ { "id": "LETM1_DROME", "url": "https://www.uniprot.org/uniprot/P91927", "type": "external" } ], "mass": 113580.0, "length": 1013, "protein_name": "Mitochondrial proton/calcium exchanger protein", "gene_name": "Letm1", "organism": "Fruit fly", "refseq_name": "leucine zipper and EF-hand containing transmembrane protein 1, isoform B", "refseq_ac": [ { "id": "NP_611922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611922", "type": "external" } ], "gene_names_uniprotkb": "Letm1; CG4589; anon-60Da", "gene_names_refseq": "B4D; CG4589; DmLETM1; Dmel\\CG4589; Letm1; anon-60Da; anon60Da; dLetm1; l(2)k10502; letm1", "protein_names_uniprotkb": "Mitochondrial proton/calcium exchanger protein; Leucine zipper-EF-hand-containing transmembrane protein 1; dLetm1", "protein_names_refseq": "CG4589-PB; LETM1 ortholog; Letm1-PB; lethal (2) k10502; leucine zipper and EF-hand containing transmembrane protein 1, isoform B", "tax_id": 7227, "disease": "Wolf-Hirschhorn syndrome (Disease Ontology:DOID:0050460); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (dme:Dmel_CG4589)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10071211;10731132;12537569;12537572;19797662", "class_list": "", "function": "Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4UZV1;Q0E8W7;Q9W160", "ec_number_list": [], "go_molecular_function": "GO:0015386 potassium:proton antiporter activity;GO:0022857 transmembrane transporter activity;GO:0005509 calcium ion binding;GO:0005432 calcium:sodium antiporter activity;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0098793 presynapse", "go_biological_process": "GO:0071456 cellular response to hypoxia;GO:0007005 mitochondrion organization;GO:0007269 neurotransmitter secretion;GO:0006851 mitochondrial calcium ion transmembrane transport;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P91927-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P92189-1", "uniprot_id": [ { "id": "STIL_DROME", "url": "https://www.uniprot.org/uniprot/P92189", "type": "external" } ], "mass": 35776.0, "length": 321, "protein_name": "Protein stand still", "gene_name": "stil", "organism": "Fruit fly", "refseq_name": "stand still", "refseq_ac": [ { "id": "NP_476752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476752", "type": "external" } ], "gene_names_uniprotkb": "stil; CG8592", "gene_names_refseq": "152072_at; CG8592; Dmel\\CG8592; Stil; Y10276; stil", "protein_names_uniprotkb": "Protein stand still", "protein_names_refseq": "CG8592-PA; stand still; stil-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8592)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10101125;10731132;12537569;12537572;9093851", "class_list": "", "function": "Essential in the female germline for proper survival, sex determination and differentiation. Participates in the transcriptional activation of Otu. Does not regulate the expression of Ovo., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9V6D8", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0048477 oogenesis;GO:0018992 germ-line sex determination;GO:0030237 female sex determination", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P92189-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00174-1", "uniprot_id": [ { "id": "LAMA_DROME", "url": "https://www.uniprot.org/uniprot/Q00174", "type": "external" } ], "mass": 411157.0, "length": 3712, "protein_name": "Laminin subunit alpha", "gene_name": "LanA", "organism": "Fruit fly", "refseq_name": "laminin A", "refseq_ac": [ { "id": "NP_476617", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476617", "type": "external" } ], "gene_names_uniprotkb": "LanA; CG10236; lamA", "gene_names_refseq": "5]]; CG10236; CT28769; Dmel\\CG10236; FBgn0002526; FBtr0077014; LM-A/alpha1; LMalpha1; Lam-A; LamA; Laminin; Lam; LanA; Lan; alpha3/5; alpha[[3; hdln; lamA; laminin alpha3/5; lanA", "protein_names_uniprotkb": "Laminin subunit alpha; Laminin A chain", "protein_names_refseq": "CG10236-PA; LanA-PA; alpha3,5 laminin; headline; laminin A chain; laminin A subunit; laminin A5; laminin A; laminin alpha-chain; laminin alpha3,5; laminin alpha[[3,5]]; lamininA", "tax_id": 7227, "disease": "junctional epidermolysis bullosa non-Herlitz type (Disease Ontology:DOID:0060738); bent bone dysplasia syndrome 2 (Disease Ontology:DOID:0060993); nephrotic syndrome type 26 (Disease Ontology:DOID:0061193); familial nephrotic syndrome (Disease Ontology:DOID:2590); cystic kidney disease (Disease Ontology:DOID:2975); junctional epidermolysis bullosa (Disease Ontology:DOID:3209); lung small cell carcinoma (Disease Ontology:DOID:5409)", "pathway": " (dme:Dmel_CG10236)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10731132;12537572;1425586;1744083;17893096;23054837;28604694;33925313;8223265", "class_list": "", "function": "Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Activates presynaptic signaling involving integrin alpha-PS3/beta-nu and Fak to suppress neuromuscular junction (NMJ) growth during larval development and during low crawling activity, but not during higher-crawling conditions. Mediates, together with integrin alpha-PS3/beta-nu, glutamate receptor-modulated NMJ growth., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 31, "predicted_n_glycosites": 30, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 33, "binding_glycan_count": 0, "secondary_ac_list": "Q9VRW0", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0030424 axon;GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0008021 synaptic vesicle;GO:0036062 presynaptic periactive zone", "go_biological_process": "GO:0007507 heart development;GO:0030155 regulation of cell adhesion;GO:0033627 cell adhesion mediated by integrin;GO:0009887 animal organ morphogenesis;GO:0034446 substrate adhesion-dependent cell spreading", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q00174-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000100000000000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00637-1", "uniprot_id": [ { "id": "SODM_DROME", "url": "https://www.uniprot.org/uniprot/Q00637", "type": "external" } ], "mass": 24659.0, "length": 217, "protein_name": "Superoxide dismutase [Mn], mitochondrial", "gene_name": "Sod2", "organism": "Fruit fly", "refseq_name": "superoxide dismutase 2 (Mn), isoform B", "refseq_ac": [ { "id": "NP_001286503", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286503", "type": "external" } ], "gene_names_uniprotkb": "Sod2; CG8905", "gene_names_refseq": "CG8905; Dmel\\CG8905; MN-SOD; Mito SOD; Mn SOD; Mn-SOD2; Mn-SOD; MnSODII; MnSODa; MnSOD; MnSod; Mn[2+]SOD; SOD-2; SOD-m; SOD2; SOD; Sod-2; Sod2; Sod; dSOD2; dSod2; mitSOD2; mnSOD; sod2", "protein_names_uniprotkb": "Superoxide dismutase [Mn], mitochondrial; 1.15.1.1", "protein_names_refseq": "CG8905-PB; Mn superoxide dismutase; Mn-superoxide dismutase; Sod2-PB; Superoxidedismutase2 (Mn); manganese superoxide dismutase; manganese-SOD; mitochodnrial SOD; mitochondrial Mn-superoxide dismutase 2; mitochondrial MnSOD; mitochondrial superoxide dismutase 2; superoxide dismutase 2 (Mn), isoform B; superoxide dismutase-2; superoxide dismutases 2; superoxide dismutatase 2", "tax_id": 7227, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); amyotrophic lateral sclerosis type 1 (Disease Ontology:DOID:0060193); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); sensorineural hearing loss (Disease Ontology:DOID:10003); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); urinary bladder cancer (Disease Ontology:DOID:11054); adult respiratory distress syndrome (Disease Ontology:DOID:11394); osteoporosis (Disease Ontology:DOID:11476); diabetic angiopathy (Disease Ontology:DOID:11713); nephrotic syndrome (Disease Ontology:DOID:1184); optic neuritis (Disease Ontology:DOID:1210); primary biliary cholangitis (Disease Ontology:DOID:12236); vitiligo (Disease Ontology:DOID:12306); dilated cardiomyopathy (Disease Ontology:DOID:12930); lung cancer (Disease Ontology:DOID:1324); exfoliation syndrome (Disease Ontology:DOID:13641); polyneuropathy (Disease Ontology:DOID:1389); bladder neck obstruction (Disease Ontology:DOID:13948); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); Parkinson's disease (Disease Ontology:DOID:14330); neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503); hypothyroidism (Disease Ontology:DOID:1459); urticaria (Disease Ontology:DOID:1555); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); cystitis (Disease Ontology:DOID:1679); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); melanoma (Disease Ontology:DOID:1909); transient cerebral ischemia (Disease Ontology:DOID:224); ovarian cancer (Disease Ontology:DOID:2394); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); bilirubin metabolic disorder (Disease Ontology:DOID:2741); asthma (Disease Ontology:DOID:2841); carotid artery disease (Disease Ontology:DOID:3407); inclusion body myositis (Disease Ontology:DOID:3429); Canavan disease (Disease Ontology:DOID:3613); Leigh disease (Disease Ontology:DOID:3652); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); brain edema (Disease Ontology:DOID:4724); esophagus adenocarcinoma (Disease Ontology:DOID:4914); liver cirrhosis (Disease Ontology:DOID:5082); intestinal disease (Disease Ontology:DOID:5295); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); reactive arthritis (Disease Ontology:DOID:6196); hepatocellular carcinoma (Disease Ontology:DOID:684); Leber hereditary optic neuropathy (Disease Ontology:DOID:705); abdominal aortic aneurysm (Disease Ontology:DOID:7693); infectious mononucleosis (Disease Ontology:DOID:8568); mycosis fungoides (Disease Ontology:DOID:8691); psoriasis (Disease Ontology:DOID:8893); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); hyperhomocysteinemia (Disease Ontology:DOID:9279); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dme:Dmel_CG8905); (R-DME-3299685)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537572;1556751;8206377", "class_list": "", "function": "Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 64, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4LGQ1;Q9V7T8", "ec_number_list": [ { "id": "1.15.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0016209 antioxidant activity;GO:0004784 superoxide dismutase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:1901526 positive regulation of mitophagy;GO:0048167 regulation of synaptic plasticity;GO:0003007 heart morphogenesis;GO:0072593 reactive oxygen species metabolic process;GO:0038001 paracrine signaling", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q00637-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00725-1", "uniprot_id": [ { "id": "SGS4_DROME", "url": "https://www.uniprot.org/uniprot/Q00725", "type": "external" } ], "mass": 32309.0, "length": 297, "protein_name": "Salivary glue protein Sgs-4", "gene_name": "Sgs4", "organism": "Fruit fly", "refseq_name": "salivary gland secretion 4", "refseq_ac": [ { "id": "NP_476717", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476717", "type": "external" } ], "gene_names_uniprotkb": "Sgs4; CG12181; Sgs-4", "gene_names_refseq": "CG12181; Dmel\\CG12181; EG:96G10.6; SGS-4; SGS4; Sgs-4; Sgs4; Sgs; sgs-4; sgs4", "protein_names_uniprotkb": "Salivary glue protein Sgs-4", "protein_names_refseq": "CG12181-PC; Sgs4-PC; salivary gland secretion 4; salivary gland secretion protein 4", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12181)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;10731137;12537572;1562607;40245499;6817924", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O76917;Q24438;Q24504;Q24513;Q24514;Q24515;Q24516;Q24517;Q7JMJ3;Q7JQ97;Q7JQ98;Q7JQ99;Q7JQA0;Q7JQA1;Q7JQA2;Q9W4T2", "ec_number_list": [], "go_molecular_function": "GO:0140073 bioadhesive activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007594 puparial adhesion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q00725-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01069-1", "uniprot_id": [ { "id": "ESMB_DROME", "url": "https://www.uniprot.org/uniprot/Q01069", "type": "external" } ], "mass": 21494.0, "length": 195, "protein_name": "Enhancer of split mbeta protein", "gene_name": "E(spl)mbeta-HLH", "organism": "Fruit fly", "refseq_name": "enhancer of split mbeta, helix-loop-helix", "refseq_ac": [ { "id": "NP_524505", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524505", "type": "external" } ], "gene_names_uniprotkb": "E(spl)mbeta-HLH; CG14548; HLHmbeta", "gene_names_refseq": "CG14548; Dm-mA; Dmel\\CG14548; E(Spl) HLH-Mbeta; E(Spl)mbeta; E(spl) mbeta; E(spl)-Mbeta; E(spl)-mbeta; E(spl)Mbeta; E(spl)beta; E(spl)mA; E(spl)mbeta-HLH; E(spl)mbeta; E(spl)mb; E(spl); HLH-mbeta; HLHMbeta; HLHm beta; HLHmA; HLHmbeta; Mbeta; bHLHb34; m-beta; mA; mbeta; mb", "protein_names_uniprotkb": "Enhancer of split mbeta protein; E(spl)mbeta; HLH-mbeta; Split locus enhancer protein mA", "protein_names_refseq": "CG14548-PA; E(spl) region transcript mbeta; E(spl)mbeta-HLH-PA; enhancer of split m-beta; enhancer of split mbeta, helix-loop-helix; enhancer of split mbeta; enhancer of split region transcript HLHmA; split locus enhancer protein mA", "tax_id": 7227, "disease": "hemangiopericytoma (Disease Ontology:DOID:264)", "pathway": " (dme:Dmel_CG14548)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10731132;12537569;12537572;1427040;1528887;15537803;22357926", "class_list": "", "function": "Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity). May serve as a transcriptional regulator of the Achaete-scute complex (AS-C) genes (PubMed:1528887). Contributes to the neural-epidermal lineage decision during early neurogenesis (PubMed:1427040). Part of the Notch signaling pathway (PubMed:1427040)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q01906;Q540X9;Q5S4K3;Q9VBJ0", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway;GO:0007399 nervous system development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q01069-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02427-3", "uniprot_id": [ { "id": "RBP1_DROME", "url": "https://www.uniprot.org/uniprot/Q02427", "type": "external" } ], "mass": 16013.0, "length": 144, "protein_name": "RNA-binding protein 1", "gene_name": "Rbp1", "organism": "Fruit fly", "refseq_name": "RNA-binding protein 1, isoform A", "refseq_ac": [ { "id": "NP_524307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524307", "type": "external" } ], "gene_names_uniprotkb": "Rbp1; CG17136; Rbp11", "gene_names_refseq": "CG17136; Dmel\\CG17136; RBP1; RRM11; RRM1; Rbp-1; Rbp11; Rbp1D; Rbp1; SRSF3; rbp1; rrm11; rrm1", "protein_names_uniprotkb": "RNA-binding protein 1", "protein_names_refseq": "CG17136-PA; RNA-binding protein 1, isoform A; RNA-binding protein 11; Rbp1-PA", "tax_id": 7227, "disease": "ovary epithelial cancer (Disease Ontology:DOID:2152); bipolar disorder (Disease Ontology:DOID:3312)", "pathway": " (dme:Dmel_CG17136); (R-DME-159236); (R-DME-72163); (R-DME-72165); (R-DME-72203); (R-DME-9770562)", "pathway_count": 6, "publication_count": 8, "publication_id_list": "10731132;12537569;12537572;1340470;17828581;32966759;7664738;8417324", "class_list": "", "function": "Contributes to the activation of female-specific DSX splicing in vivo by recognizing the RBP1 target sequences within the purine-rich polypyrimidine tract of the female-specific 3' splice site., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4V2P0;Q26271;Q26280;Q8T9K6;Q9VGW8", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0000791 euchromatin", "go_biological_process": "GO:0008380 RNA splicing;GO:0010468 regulation of gene expression;GO:0000381 regulation of alternative mRNA splicing, via spliceosome;GO:0045292 mRNA cis splicing, via spliceosome;GO:0031440 regulation of mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q02427-3", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03042-1", "uniprot_id": [ { "id": "KGP1_DROME", "url": "https://www.uniprot.org/uniprot/Q03042", "type": "external" } ], "mass": 86759.0, "length": 768, "protein_name": "cGMP-dependent protein kinase, isozyme 1", "gene_name": "Pkg21D", "organism": "Fruit fly", "refseq_name": "protein kinase, cGMP-dependent at 21D", "refseq_ac": [ { "id": "NP_477213", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477213", "type": "external" } ], "gene_names_uniprotkb": "Pkg21D; CG3324; DG1", "gene_names_refseq": "CG3324; DG1; Dg1; Dmel\\CG3324; PKG 21D; PKG-21D; PKG1; PKG21D; PKG; Pkg1; Pkg21D; cGMP; dg1; pkg21D", "protein_names_uniprotkb": "cGMP-dependent protein kinase, isozyme 1; 2.7.11.12; cGK", "protein_names_refseq": "CG3324-PA; Pkg21D-PA; cGMP-dependent protein kinase 21D; protein kinase, cGMP-dependent at 21D", "tax_id": 7227, "disease": "withdrawal disorder (Disease Ontology:DOID:0060001); ciliopathy (Disease Ontology:DOID:0060340); acromesomelic dysplasia 4 (Disease Ontology:DOID:0081238); spondylometaphyseal dysplasia (Disease Ontology:DOID:0112295); malignant renovascular hypertension (Disease Ontology:DOID:13730)", "pathway": " (dme:Dmel_CG3324)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;2732245;2828348;8798533", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24566;Q9V403", "ec_number_list": [ { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "5.6.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.8", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" } ], "go_molecular_function": "GO:0004692 cGMP-dependent protein kinase activity;GO:0005524 ATP binding;GO:0030553 cGMP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0007526 larval somatic muscle development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q03042-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03334-1", "uniprot_id": [ { "id": "RS13_DROME", "url": "https://www.uniprot.org/uniprot/Q03334", "type": "external" } ], "mass": 17178.0, "length": 151, "protein_name": "Small ribosomal subunit protein uS15", "gene_name": "RpS13", "organism": "Fruit fly", "refseq_name": "ribosomal protein S13, isoform B", "refseq_ac": [ { "id": "NP_001033885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033885", "type": "external" } ], "gene_names_uniprotkb": "RpS13; CG13389; Dmel\\CG13389; Dmel_CG13389; M(2)29B; M(2)32A; M(2)32; RPS13; Rp S13; Rp17; Rps 13; Rps13; S13; S15; l(2)k09614; rpS13", "gene_names_refseq": "CG13389; Dmel\\CG13389; M(2)29B; M(2)32A; M(2)32; RPS13; Rp S13; Rp17; RpS13; Rps 13; Rps13; S13; S15; l(2)k09614; rpS13", "protein_names_uniprotkb": "Small ribosomal subunit protein uS15; 40S ribosomal protein S13", "protein_names_refseq": "CG13389-PB; Minute(2)32A; RpS13-PB; ribosomal protein S13, isoform B; ribosomal protein S17", "tax_id": 7227, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)", "pathway": " (dme:Dmel_CG13389); (R-DME-156827); (R-DME-1799339); (R-DME-6791226); (R-DME-72649); (R-DME-72689); (R-DME-72695); (R-DME-72702); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 13, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;23636399;25589440;26109356;26109357;8506150;8725235", "class_list": "", "function": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V0F6;Q9VLN5", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0070181 small ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0022626 cytosolic ribosome;GO:0032040 small-subunit processome;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0042274 ribosomal small subunit biogenesis;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q03334-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04047-1", "uniprot_id": [ { "id": "NONA_DROME", "url": "https://www.uniprot.org/uniprot/Q04047", "type": "external" } ], "mass": 76977.0, "length": 700, "protein_name": "Protein no-on-transient A", "gene_name": "nonA", "organism": "Fruit fly", "refseq_name": "no on or off transient A, isoform C", "refseq_ac": [ { "id": "NP_001014747", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014747", "type": "external" } ], "gene_names_uniprotkb": "nonA; Bj6-1; Bj6; CG4211; Dmel\\CG4211; Dmel_CG4211; NONA; NonA; dNONO; diss; non-A; nona; opm2; p54[nrb]; x14", "gene_names_refseq": "Bj6-1; Bj6; CG4211; Dmel\\CG4211; NONA; NonA; dNONO; diss; non-A; nonA/diss; nonA; nona; opm2; p54[nrb]; x14", "protein_names_uniprotkb": "Protein no-on-transient A; Puff-specific protein Bj6", "protein_names_refseq": "Bj6-monoclonal-antibody; CG4211-PC; dissonance; no on or off transient A, isoform C; no on or off transient-A; no-on transient A; no-on-transient A; no-on-transient-A; non-on-transient-A; nonA-PC; positive spike II group", "tax_id": 7227, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); syndromic X-linked intellectual disability 34 (Disease Ontology:DOID:0060817); aortic dissection (Disease Ontology:DOID:0080685); intellectual disability (Disease Ontology:DOID:1059); atherosclerosis (Disease Ontology:DOID:1936); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (dme:Dmel_CG4211)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;2129286;2344408;25589440;26109356;26109357", "class_list": "", "function": "Required for normal vision and courtship behavior in Drosophila., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24261;Q59E42;Q9VXH1", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0071013 catalytic step 2 spliceosome;GO:0071011 precatalytic spliceosome", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0007601 visual perception;GO:0000398 mRNA splicing, via spliceosome;GO:0007632 visual behavior;GO:0042331 phototaxis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q04047-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05856-1", "uniprot_id": [ { "id": "RSMB_DROME", "url": "https://www.uniprot.org/uniprot/Q05856", "type": "external" } ], "mass": 21021.0, "length": 199, "protein_name": "Small nuclear ribonucleoprotein-associated protein B", "gene_name": "SmB", "organism": "Fruit fly", "refseq_name": "small ribonucleoprotein particle protein SmB", "refseq_ac": [ { "id": "NP_001188780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001188780", "type": "external" } ], "gene_names_uniprotkb": "SmB; CG5352", "gene_names_refseq": "B; CG5352; Dmel\\CG5352; SYM10; Sm B; SmB1; SmB; Smb; dSmB; l(2)SH0509; l(2)SH2 0509; smb; snRNP B", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein-associated protein B; Sm protein B; Sm-B; SmB; snRNP-B", "protein_names_refseq": "CG5352-PB; SmB-PB; lethal (2) SH0509; polypeptide B; small ribonucleoprotein particle protein B; small ribonucleoprotein particle protein SmB", "tax_id": 7227, "disease": "cerebrocostomandibular syndrome (Disease Ontology:DOID:0111248); Prader-Willi syndrome (Disease Ontology:DOID:11983); Angelman syndrome (Disease Ontology:DOID:1932); mixed connective tissue disease (Disease Ontology:DOID:3492); lung adenocarcinoma (Disease Ontology:DOID:3910); tauopathy (Disease Ontology:DOID:680)", "pathway": " (dme:Dmel_CG5352); (R-DME-111367); (R-DME-72163); (R-DME-72165); (R-DME-73856); (R-DME-77588); (R-DME-9770562); (R-DME-9943411)", "pathway_count": 8, "publication_count": 11, "publication_id_list": "10731132;12537569;12537572;16753561;17164419;18369183;18621711;20570937;20659974;23885126;7680326", "class_list": "", "function": "Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Involved in germline establishment and development (PubMed:20570937, PubMed:20659974)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "M9MRL9", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0070990 snRNP binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0036261 7-methylguanosine cap hypermethylation;GO:0007281 germ cell development;GO:0000398 mRNA splicing, via spliceosome;GO:0008406 gonad development;GO:0071045 nuclear histone mRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q05856-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08012-1", "uniprot_id": [ { "id": "GRAP_DROME", "url": "https://www.uniprot.org/uniprot/Q08012", "type": "external" } ], "mass": 24435.0, "length": 211, "protein_name": "Growth factor receptor-bound protein 2", "gene_name": "drk", "organism": "Fruit fly", "refseq_name": "downstream of receptor kinase, isoform A", "refseq_ac": [ { "id": "NP_476858", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476858", "type": "external" } ], "gene_names_uniprotkb": "drk; CG6033; E(sev)2B; Grb2", "gene_names_refseq": "24/1; CG6033; DRK; Dmel\\CG6033; Drk/Grb2; Drk; E(sev)2B; GRB2; Grb-2; Grb/drk; Grb2/drk; Grb2; P1112; Su(sev)R1; crkl; drk; l(2)10626; l(2)k13809", "protein_names_uniprotkb": "Growth factor receptor-bound protein 2; Downstream of receptor kinase; Protein enhancer of sevenless 2B", "protein_names_refseq": "CG6033-PA; downstream of receptor kinase, isoform A; downstream of receptor kinases; downstream of receptor kinase; downstream receptor kinase; drk-PA; enhancer of sevenless-2B", "tax_id": 7227, "disease": "autosomal recessive nonsyndromic deafness 114 (Disease Ontology:DOID:0111642); prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); prostate adenocarcinoma (Disease Ontology:DOID:2526); endometrial carcinoma (Disease Ontology:DOID:2871)", "pathway": " (dme:Dmel_CG6033); (R-DME-109704); (R-DME-112412); (R-DME-1250347); (R-DME-1257604); (R-DME-1295596); (R-DME-1433557); (R-DME-1433559); (R-DME-167044); (R-DME-179812); (R-DME-180292); (R-DME-180336); (R-DME-182971); (R-DME-186763); (R-DME-1963640); (R-DME-1963642); (R-DME-2029482); (R-DME-210993); (R-DME-2179392); (R-DME-2424491); (R-DME-2428933); (R-DME-2730905); (R-DME-2871796); (R-DME-2871809); (R-DME-375165); (R-DME-5654688); (R-DME-5654689); (R-DME-5654693); (R-DME-5654695); (R-DME-5654699); (R-DME-5654700); (R-DME-5654704); (R-DME-5654706); (R-DME-5654710); (R-DME-5654712); (R-DME-5654719); (R-DME-5654720); (R-DME-5654726); (R-DME-5654727); (R-DME-5654732); (R-DME-5654733); (R-DME-5663213); (R-DME-5673001); (R-DME-6811558); (R-DME-74749); (R-DME-74751); (R-DME-8853659); (R-DME-8856825); (R-DME-8856828); (R-DME-9013420); (R-DME-912631); (R-DME-9607240); (R-DME-983695)", "pathway_count": 53, "publication_count": 11, "publication_id_list": "10731132;12128212;12537569;12537572;12694293;16300404;22615583;30610177;8462097;8462098;9671493", "class_list": "", "function": "Adapter protein which modulates signaling mediated by several receptor tyrosine kinases such as sev and Ack (PubMed:22615583, PubMed:8462097, PubMed:8462098). Required for proper signaling by sevenless (PubMed:8462097, PubMed:8462098). May act to stimulate the ability of Sos to catalyze Ras1 activation by linking sevenless and Sos in a signaling complex (PubMed:8462097, PubMed:8462098). Required for functional and morphological integrities of the scolopidia, sensory neurons and the antennal mechanosensory and motor center (AMMC) brain neuropil (PubMed:30610177). Required for Ack-dependent suppression of apoptosis in the eye (PubMed:22615583)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4UZF9;Q0E989;Q9V6Q5", "ec_number_list": [], "go_molecular_function": "GO:0005118 sevenless binding;GO:0001784 phosphotyrosine residue binding;GO:0005154 epidermal growth factor receptor binding;GO:0030159 signaling receptor complex adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0098793 presynapse;GO:0032991 protein-containing complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0007165 signal transduction;GO:0008306 associative learning;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0007614 short-term memory", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q08012-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q09101-1", "uniprot_id": [ { "id": "HIG_DROME", "url": "https://www.uniprot.org/uniprot/Q09101", "type": "external" } ], "mass": 107028.0, "length": 958, "protein_name": "Locomotion-related protein Hikaru genki", "gene_name": "hig", "organism": "Fruit fly", "refseq_name": "hikaru genki, isoform D", "refseq_ac": [ { "id": "NP_001014514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014514", "type": "external" } ], "gene_names_uniprotkb": "hig; CG2040", "gene_names_refseq": "CG2040; CT6282; Dmel\\CG2040; HIG; Hig; hig", "protein_names_uniprotkb": "Locomotion-related protein Hikaru genki", "protein_names_refseq": "CG2040-PD; hig-PD; hikaru genki, isoform D; hikaru genki", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2040); (R-DME-114608); (R-DME-202733); (R-DME-373080); (R-DME-6798695); (R-DME-6807878)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "10731132;12537569;12537572;17893096;8461133;8625810;9914413", "class_list": "", "function": "Plays a role in the formation of functional neural circuits from the early stages of synapse formation. Has a role in the development of CNS functions involved in locomotor activity., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q7KQU0;Q8IH50;Q9I7E3;Q9I7E4;Q9V560", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0043025 neuronal cell body;GO:0043083 synaptic cleft", "go_biological_process": "GO:0008039 synaptic target recognition", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q09101-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q09332-1", "uniprot_id": [ { "id": "UGGG_DROME", "url": "https://www.uniprot.org/uniprot/Q09332", "type": "external" } ], "mass": 174354.0, "length": 1548, "protein_name": "UDP-glucose:glycoprotein glucosyltransferase", "gene_name": "Uggt", "organism": "Fruit fly", "refseq_name": "UDP-glucose-glycoprotein glucosyltransferase", "refseq_ac": [ { "id": "NP_524151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524151", "type": "external" } ], "gene_names_uniprotkb": "Uggt; CG6850; GT; UGGG; Ugt", "gene_names_refseq": "CG6850; DUGT; DmUGGT; Dmel\\CG6850; GT; UGGT; UGT; Uggt; Ugt; anon-WO0172774.73; anon-WO0172774.75; ugt", "protein_names_uniprotkb": "UDP-glucose:glycoprotein glucosyltransferase; 2.4.1.-; UDP--Glc:glycoprotein glucosyltransferase; UGT; dUGT", "protein_names_refseq": "CG6850-PA; UDP-glucose-glycoprotein glucosyltransferase; UDP-glucose:glycoprotein glucosyltransferase; Uggt-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6850)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10731132;11535823;12537569;12537572;22960071;28490633;7729408", "class_list": "glycogene;glycosyltransferase", "function": "Recognizes glycoproteins with minor folding defects (PubMed:22960071). Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum (PubMed:22960071). Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation (PubMed:11535823)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B5RIN4;Q95U28;Q9VVT7", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005791 rough endoplasmic reticulum", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q09332-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000100000000000.0000000011000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0E908-1", "uniprot_id": [ { "id": "HIL_DROME", "url": "https://www.uniprot.org/uniprot/Q0E908", "type": "external" } ], "mass": 94465.0, "length": 818, "protein_name": "Hillarin", "gene_name": "Hil", "organism": "Fruit fly", "refseq_name": "hillarin, isoform A", "refseq_ac": [ { "id": "NP_611493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611493", "type": "external" } ], "gene_names_uniprotkb": "Hil; CG30147", "gene_names_refseq": "CG10439; CG13435; CG30147; D-hil; Dmel\\CG30147; Hil", "protein_names_uniprotkb": "Hillarin; D-Hillarin; D-hil", "protein_names_refseq": "CG30147-PA; D-hillarin; Hil-PA; hillarin, isoform A", "tax_id": 7227, "disease": "myofibrillar myopathy 7 (Disease Ontology:DOID:0080098)", "pathway": " (dme:Dmel_CG30147)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;15818553", "class_list": "", "function": "May act as a modulator of septin function during cytokinesis in the developing nervous system., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q960G2", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005938 cell cortex;GO:0032154 cleavage furrow", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q0E908-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0E959-1", "uniprot_id": [ { "id": "RM34_DROME", "url": "https://www.uniprot.org/uniprot/Q0E959", "type": "external" } ], "mass": 9381.0, "length": 81, "protein_name": "Large ribosomal subunit protein bL34m", "gene_name": "mRpL34", "organism": "Fruit fly", "refseq_name": "mitochondrial ribosomal protein L34", "refseq_ac": [ { "id": "NP_001036552", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036552", "type": "external" } ], "gene_names_uniprotkb": "mRpL34; CG34147", "gene_names_refseq": "CG34147; Dmel\\CG34147; mRpL34", "protein_names_uniprotkb": "Large ribosomal subunit protein bL34m; 39S ribosomal protein L34, mitochondrial; L34mt; MRP-L34", "protein_names_refseq": "CG34147-PA; mRpL34-PA; mitochondrial ribosomal protein L34", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG34147); (R-DME-5389840); (R-DME-5419276); (R-DME-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0E959-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0E9G3-1", "uniprot_id": [ { "id": "KTU_DROME", "url": "https://www.uniprot.org/uniprot/Q0E9G3", "type": "external" } ], "mass": 94774.0, "length": 834, "protein_name": "Protein kintoun", "gene_name": "Nop17l", "organism": "Fruit fly", "refseq_name": "Nop17 like, isoform A", "refseq_ac": [ { "id": "NP_610324", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610324", "type": "external" } ], "gene_names_uniprotkb": "Nop17l; CG1553; Ppi20", "gene_names_refseq": "CG1553; Dmel\\CG1553; Nop17l; nop17l", "protein_names_uniprotkb": "Protein kintoun; Dynein assembly factor 2, axonemal homolog; PP1-interacting protein 20", "protein_names_refseq": "CG1553-PA; NOP17 like; Nop17 like, isoform A; Nop17l-PA", "tax_id": 7227, "disease": "primary ciliary dyskinesia 10 (Disease Ontology:DOID:0110612)", "pathway": " (dme:Dmel_CG1553)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;17007873;18327897", "class_list": "", "function": "Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C7LA99;E2QC75;Q8T8Q3", "ec_number_list": [], "go_molecular_function": "GO:0008157 protein phosphatase 1 binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0060285 cilium-dependent cell motility;GO:0070286 axonemal dynein complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q0E9G3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0KHU5-1", "uniprot_id": [ { "id": "PCAT_DROME", "url": "https://www.uniprot.org/uniprot/Q0KHU5", "type": "external" } ], "mass": 60038.0, "length": 533, "protein_name": "Lysophosphatidylcholine acyltransferase", "gene_name": "LPCAT", "organism": "Fruit fly", "refseq_name": "lysophosphatidylcholine acyltransferase", "refseq_ac": [ { "id": "NP_001036265", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036265", "type": "external" } ], "gene_names_uniprotkb": "LPCAT; CG32699", "gene_names_refseq": "CG15318; CG18535; CG2996; CG32699; CT7882; Dmel\\CG32699; LPCAT1/2; LPCAT; tok-like", "protein_names_uniprotkb": "Lysophosphatidylcholine acyltransferase; 1-acylglycerophosphocholine O-acyltransferase; 2.3.1.23; Acyltransferase-like 2", "protein_names_refseq": "CG32699-PB; LPCAT-PB; Lyso-PA acyltransferase; lysophosphatidylcholine acyltransferase", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32699); (R-DME-1482788); (R-DME-1482801); (R-DME-1482839); (R-DME-1482925); (R-DME-1483166); (R-DME-6798695)", "pathway_count": 7, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;17018572;25491198", "class_list": "", "function": "Acetyltransferase which mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC) (By similarity). Has a calcium-independent activity (By similarity). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (By similarity). Involved in the regulation of lipid droplet number and size (PubMed:25491198)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q86NX4;Q95SE4;Q9W331", "ec_number_list": [ { "id": "2.3.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.-.-", "type": "external" }, { "id": "2.3.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.n6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n6", "type": "external" }, { "id": "2.3.1.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n7", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "3.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.25", "type": "external" } ], "go_molecular_function": "GO:0042171 lysophosphatidic acid acyltransferase activity;GO:0005509 calcium ion binding;GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity;GO:0071617 lysophospholipid acyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008654 phospholipid biosynthetic process;GO:0030258 lipid modification", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q0KHU5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0KHY3-3", "uniprot_id": [ { "id": "MESH_DROME", "url": "https://www.uniprot.org/uniprot/Q0KHY3", "type": "external" } ], "mass": 165038.0, "length": 1454, "protein_name": "Protein mesh", "gene_name": "mesh", "organism": "Fruit fly", "refseq_name": "mesh, isoform C", "refseq_ac": [ { "id": "NP_001163781", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163781", "type": "external" } ], "gene_names_uniprotkb": "mesh; CG31004", "gene_names_refseq": "CG12074; CG15560; CG31004; CT5150; DmMesh; Dmel\\CG31004; Mesh; anon-WO0140519.233; mesh", "protein_names_uniprotkb": "Protein mesh", "protein_names_refseq": "CG31004-PC; mesh, isoform C; mesh-PC", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31004); (R-DME-913709); (R-DME-977068)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10731132;12537569;12537572;17893096;18327897;22854041;26848177;33925313", "class_list": "", "function": "Required, together with Ssk and Tsp2A, for the proper organization of smooth septate junctions (sSJs), probably by mediating cell adhesion via its homophilic interaction (PubMed:22854041, PubMed:26848177). Also required for the correct subcellular localization of several sSJ components, such as Ssk, cora and l(2)gl, and for the barrier function of the midgut epithelium (PubMed:22854041). Required for maintaining the three-layered structure of the proventriculus (PubMed:22854041)., [UniProtKB, PubMed]", "predicted_glycosites": 13, "predicted_n_glycosites": 12, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "B3DNA3;E1JJ26;E1JJ27;E2QD49;Q6NND0;Q8MR59", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016327 apicolateral plasma membrane;GO:0005920 smooth septate junction", "go_biological_process": "GO:0007160 cell-matrix adhesion;GO:0090528 smooth septate junction assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q0KHY3-3", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1JUZ1-1", "uniprot_id": [ { "id": "NVD_DROME", "url": "https://www.uniprot.org/uniprot/Q1JUZ1", "type": "external" } ], "mass": 50106.0, "length": 429, "protein_name": "Cholesterol 7-desaturase nvd", "gene_name": "nvd", "organism": "Fruit fly", "refseq_name": "neverland", "refseq_ac": [ { "id": "NP_001097670", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097670", "type": "external" } ], "gene_names_uniprotkb": "nvd; CG40050", "gene_names_refseq": "80Fc; CG40050; Dmel\\CG40050; NVD; Nvd; l(3)80Fc; l(3)Lh6; l6; nvd-Dm; nvd", "protein_names_uniprotkb": "Cholesterol 7-desaturase nvd; 1.14.19.21; Neverland; Nvd_Dm; Rieske-domain protein Neverland", "protein_names_refseq": "CG40050-PA; lethal (3) 80Fc; lethal 6; lethal6; neverland; nvd-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG40050)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;16763204;21632547", "class_list": "", "function": "Catalyzes the production of 7-dehydrocholesterol (7-DHC or cholesta-5,7-dien-3beta-ol) by inserting a double bond (desaturating) at the C7-C8 single bond of cholesterol (PubMed:21632547). Essential regulator of steroid biosynthesis, as this reaction is the first step in the synthesis of the steroid hormone Delta(7)-dafachronic acid (PubMed:16763204, PubMed:21632547). Required for insect molting, metamorphosis and body growth throughout development via the regulation of ecdysteroid biosynthesis in the prothoracic gland (PubMed:16763204)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BIG3", "ec_number_list": [ { "id": "1.14.19.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.21", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0016491 oxidoreductase activity;GO:0170056 cholesterol 7-desaturase [NAD(P)H] activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0035264 multicellular organism growth;GO:0045456 ecdysteroid biosynthetic process;GO:0002168 instar larval development;GO:0007552 metamorphosis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q1JUZ1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q23970-1", "uniprot_id": [ { "id": "PBP6_DROME", "url": "https://www.uniprot.org/uniprot/Q23970", "type": "external" } ], "mass": 16112.0, "length": 141, "protein_name": "Pheromone-binding protein-related protein 6", "gene_name": "Obp83b", "organism": "Fruit fly", "refseq_name": "Odorant-binding protein 83b", "refseq_ac": [ { "id": "NP_524242", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524242", "type": "external" } ], "gene_names_uniprotkb": "Obp83b; CG11422; Os-E; PBPRP6", "gene_names_refseq": "83b; CG11422; DmelObp83b; Dmel\\CG11422; OBP83b; OS-E; Obp83b; Os-E; PBP-H1; obp83b", "protein_names_uniprotkb": "Pheromone-binding protein-related protein 6; Odorant-binding protein OS-E; PBPRP-6", "protein_names_refseq": "CG11422-PA; Obp83b-PA; Odorant-binding protein 83b; Olfactory-specific E; Os-E; Pheromone-binding protein homolog 1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11422)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537572;14668382;8206941;9030621", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P91684;Q9VNK3", "ec_number_list": [], "go_molecular_function": "GO:0005549 odorant binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007608 sensory perception of smell;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q23970-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q23972-1", "uniprot_id": [ { "id": "SMG_DROME", "url": "https://www.uniprot.org/uniprot/Q23972", "type": "external" } ], "mass": 109065.0, "length": 999, "protein_name": "Protein Smaug", "gene_name": "smg", "organism": "Fruit fly", "refseq_name": "smaug, isoform D", "refseq_ac": [ { "id": "NP_001137924", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137924", "type": "external" } ], "gene_names_uniprotkb": "smg; CG5263", "gene_names_refseq": "CG5263; D69; Dmel\\CG5263; SMG; SmG; Smaug; Smg; anon-D69; anonD69; smg", "protein_names_uniprotkb": "Protein Smaug", "protein_names_refseq": "CG5263-PD; SMAUG; dSmaug; smaug, isoform D; smau; smg-PD", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5263)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10488336;10606265;10731132;10882131;12537569;12537572;12820967;12858164;14685270;18327897;20953170;8895661", "class_list": "", "function": "Translation regulator that binds to the 3'-UTR of specific mRNAs such as nanos (nos) and prevents their translation. Prevents translation of unlocalized nanos in the bulk cytoplasm via the recruitment of cup., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 16, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V1P7;B7Z0F4;B7Z0F5;Q9V3T0;Q9VSS8", "ec_number_list": [], "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0003729 mRNA binding;GO:0017022 myosin binding;GO:0030371 translation repressor activity;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000932 P-body;GO:0043186 P granule", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0043488 regulation of mRNA stability;GO:0017148 negative regulation of translation;GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q23972-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q23973-1", "uniprot_id": [ { "id": "MTRM_DROME", "url": "https://www.uniprot.org/uniprot/Q23973", "type": "external" } ], "mass": 24780.0, "length": 217, "protein_name": "Protein matrimony", "gene_name": "mtrm", "organism": "Fruit fly", "refseq_name": "matrimony", "refseq_ac": [ { "id": "NP_648223", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648223", "type": "external" } ], "gene_names_uniprotkb": "mtrm; CG18543; anon-D52", "gene_names_refseq": "CG18543; D52; Dmel\\CG18543; Mtrm; anon-D52; anonD52; mtrm", "protein_names_uniprotkb": "Protein matrimony; Cell cycle arrest protein D52", "protein_names_refseq": "CG18543-PA; matrimony; mtrm-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18543)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10731132;12537569;12537572;14573476;18052611;18327897;18984573;24019759;30351378", "class_list": "", "function": "Polo kinase inhibitor required to maintain G2 arrest in the meiotic cell cycle in females (PubMed:18052611). Holds heterochromatically paired homologs together from the end of pachytene until metaphase I (PubMed:14573476). Haploinsufficient locus for homologous achiasmate segregation and may be required for the maintenance of heterochromatic pairings (PubMed:14573476)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B6UX71;B6UX75;B6UX76;B6UX77;B6UX82;B6UX83;B6UX94;Q9VSJ7", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome", "go_biological_process": "GO:0045143 homologous chromosome segregation;GO:0016321 female meiosis chromosome segregation;GO:0051445 regulation of meiotic cell cycle;GO:0032837 distributive segregation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q23973-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q23983-1", "uniprot_id": [ { "id": "SNAP_DROME", "url": "https://www.uniprot.org/uniprot/Q23983", "type": "external" } ], "mass": 33000.0, "length": 292, "protein_name": "Alpha-soluble NSF attachment protein", "gene_name": "alphaSnap", "organism": "Fruit fly", "refseq_name": "alpha soluble NSF attachment protein", "refseq_ac": [ { "id": "NP_524180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524180", "type": "external" } ], "gene_names_uniprotkb": "alphaSnap; CG6625; Snap", "gene_names_refseq": "CG6625; Dmel\\CG6625; SNAP; SnapII; Snap; a-Snap; aSnap; alpha-SNAP; alpha-Snap; alpha-snap; alphaSNAP; alphaSnap; dSNAP; dalpha-SNAP; dalphaSNAP; dsnap; l(3)77ABa; l(3)77ABc; snap", "protein_names_uniprotkb": "Alpha-soluble NSF attachment protein; N-ethylmaleimide-sensitive factor attachment protein; SNAP-alpha", "protein_names_refseq": "CG6625-PA; alpha soluble NSF attachment protein; alphaSnap-PA; lethal (3) 77ABa; lethal (3) 77ABc; soluble N-ethylmaleimide-sensitive factor attachment protein; soluble NSF attachment protein; soluble NSF-attachment protein", "tax_id": 7227, "disease": "developmental and epileptic encephalopathy 107 (Disease Ontology:DOID:0070393); Alzheimer's disease (Disease Ontology:DOID:10652); Down syndrome (Disease Ontology:DOID:14250); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (dme:Dmel_CG6625); (R-DME-204005); (R-DME-6807878); (R-DME-6811434); (R-DME-6811438); (R-DME-6811440)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "10731132;12537572;17151602;8202553", "class_list": "", "function": "Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. Also between the endosome and phagosome., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q541G5", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding;GO:0000149 SNARE binding;GO:0001671 ATPase activator activity;GO:0005483 soluble NSF attachment protein activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0043195 terminal bouton;GO:0043679 axon terminus;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0035494 SNARE complex disassembly;GO:0006886 intracellular protein transport;GO:0007268 chemical synaptic transmission;GO:0000281 mitotic cytokinesis;GO:0007269 neurotransmitter secretion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q23983-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24039-1", "uniprot_id": [ { "id": "BRO_DROME", "url": "https://www.uniprot.org/uniprot/Q24039", "type": "external" } ], "mass": 25085.0, "length": 213, "protein_name": "Protein brother", "gene_name": "Bro", "organism": "Fruit fly", "refseq_name": "brother", "refseq_ac": [ { "id": "NP_477066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477066", "type": "external" } ], "gene_names_uniprotkb": "Bro; CG7960", "gene_names_refseq": "Bro; CG7960; Dmel\\CG7960; bro; rpbeta1", "protein_names_uniprotkb": "Protein brother", "protein_names_refseq": "Bro-PA; CG7960-PA; beta for runt and OTHERs; brother; runt domain partner beta1", "tax_id": 7227, "disease": "acute myelomonocytic leukemia (Disease Ontology:DOID:0081082); cleidocranial dysplasia (Disease Ontology:DOID:13994); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dme:Dmel_CG7960)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;8622696", "class_list": "", "function": "Regulates the DNA-binding properties of Runt., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W0B5", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016513 core-binding factor complex", "go_biological_process": "GO:0048749 compound eye development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0035206 regulation of hemocyte proliferation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q24039-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24139-1", "uniprot_id": [ { "id": "COMM_DROME", "url": "https://www.uniprot.org/uniprot/Q24139", "type": "external" } ], "mass": 40311.0, "length": 370, "protein_name": "Protein commissureless 1", "gene_name": "comm", "organism": "Fruit fly", "refseq_name": "commissureless, isoform B", "refseq_ac": [ { "id": "NP_001261891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261891", "type": "external" } ], "gene_names_uniprotkb": "comm; CG17943", "gene_names_refseq": "CG17943; Comm; Dmel\\CG17943; comm", "protein_names_uniprotkb": "Protein commissureless 1; Protein commissureless", "protein_names_refseq": "CG17943-PB; comm-PB; commissureless, isoform B; commissureless; commisureless", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17943)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12165468;12537572;15657595;16531238;8785048", "class_list": "", "function": "Controls axon guidance across the CNS midline by preventing the delivery of Robo to the growth cone., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VUT9", "ec_number_list": [], "go_molecular_function": "GO:0050699 WW domain binding;GO:0048495 Roundabout binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0097708 intracellular vesicle;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0007399 nervous system development;GO:0016199 axon midline choice point recognition;GO:0031623 receptor internalization;GO:0007416 synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q24139-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24145-1", "uniprot_id": [ { "id": "SHARK_DROME", "url": "https://www.uniprot.org/uniprot/Q24145", "type": "external" } ], "mass": 104273.0, "length": 939, "protein_name": "Tyrosine-protein kinase Shark", "gene_name": "Shark", "organism": "Fruit fly", "refseq_name": "SH2 ankyrin repeat kinase", "refseq_ac": [ { "id": "NP_524743", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524743", "type": "external" } ], "gene_names_uniprotkb": "Shark; CG18247; Tk7", "gene_names_refseq": "CG18247; Dmel\\CG18247; Dtk7; SHARK; SYK/SHARK; Shark; Syk; Tk7; dShark; dtk7; l(2)W4; l(2R)W4; shark", "protein_names_uniprotkb": "Tyrosine-protein kinase Shark; 2.7.10.2", "protein_names_refseq": "CG18247-PA; SH2 ankyrin repeat kinase; Shark-PA; Src homology 2 ankyrin repeat tyrosine kinase; Src homology 2, ankyrin repeat, tyrosine kinase; Src homology2, ankyrin repeat, tyrosine kinase; tyrosine kinase 7", "tax_id": 7227, "disease": "infantile onset multisystem autoimmune disease 2 (Disease Ontology:DOID:0061161); immunodeficiency 48 (Disease Ontology:DOID:0111943); severe combined immunodeficiency (Disease Ontology:DOID:627); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (dme:Dmel_CG18247)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10731132;12537569;12537572;18432193;1915852;26028435;7892198", "class_list": "", "function": "Following axon injury, required for recruitment of drpr and glial cells to severed axons and for glial clearance of severed axons from the central nervous system (PubMed:18432193). Together with Src42a and drpr, promotes the migration of macrophages to sites of wounding as part of a signaling cascade where Scr42a detects production of hydrogen peroxide at wound sites which triggers phosphorylation of drpr and subsequent recruitment and activation of shark (PubMed:26028435). May be involved in signal transduction on the apical surface of ectodermal epithelial cells, regulating their polarity during invagination (PubMed:7892198). Crumbs (crb) may be the intracellular signal (PubMed:7892198)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q26299;Q9V7K5", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0007254 JNK cascade;GO:0043277 apoptotic cell clearance;GO:0045199 maintenance of epithelial cell apical/basal polarity;GO:0007306 egg chorion assembly;GO:0007391 dorsal closure", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q24145-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24154-1", "uniprot_id": [ { "id": "RL29_DROME", "url": "https://www.uniprot.org/uniprot/Q24154", "type": "external" } ], "mass": 8920.0, "length": 76, "protein_name": "Large ribosomal subunit protein eL29", "gene_name": "RpL29", "organism": "Fruit fly", "refseq_name": "ribosomal protein L29, isoform A", "refseq_ac": [ { "id": "NP_477203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477203", "type": "external" } ], "gene_names_uniprotkb": "RpL29; CG10071; RpL43", "gene_names_refseq": "BcDNA:RH58777; CG10071; DL43; Dmel\\CG10071; L29e; L29; RpL29; RpL43; anon-EST:Posey204; anon-EST:Posey73", "protein_names_uniprotkb": "Large ribosomal subunit protein eL29; 60S ribosomal protein L29; L43", "protein_names_refseq": "60S ribosomal component; 60S ribosomal protein L43; CG10071-PA; RpL29-PA; ribosomal protein L29, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10071); (R-DME-156827); (R-DME-1799339); (R-DME-72689); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954709); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 10, "publication_count": 5, "publication_id_list": "10731132;12537572;18327897;23636399;9063649", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4UZR6;Q0E900;Q9W2I3", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022626 cytosolic ribosome;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q24154-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24168-1", "uniprot_id": [ { "id": "ORC2_DROME", "url": "https://www.uniprot.org/uniprot/Q24168", "type": "external" } ], "mass": 68996.0, "length": 618, "protein_name": "Origin recognition complex subunit 2", "gene_name": "Orc2", "organism": "Fruit fly", "refseq_name": "origin recognition complex subunit 2", "refseq_ac": [ { "id": "NP_731873", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_731873", "type": "external" } ], "gene_names_uniprotkb": "Orc2; CG3041", "gene_names_refseq": "CG3041; DmORC 2; DmORC2; DmOrc2p; DmOrc2; Dmel\\CG3041; ORC2; ORC; Orc-2; Orc2p; Orc2; dOrc2; fs(3)293-19; fs(3)293; k43; l(3)88Ab; l(3)A5; l(3)K43; l(3)SG44; l(3)dsl5; l(3)k43; orc2; rDmORC", "protein_names_uniprotkb": "Origin recognition complex subunit 2; DmORC2", "protein_names_refseq": "CG3041-PA; Orc2-PA; lethal(3)88Ab; origin recognition complex 2; origin recognition complex subunit 2; origin recognition complex", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3041); (R-DME-176187); (R-DME-68616); (R-DME-68689); (R-DME-68949); (R-DME-68962)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "10731132;11137005;11408576;12537569;12537572;12808023;18327897;27016737;30713769;7502079", "class_list": "", "function": "Component of the origin recognition complex (ORC) that binds origins of replication (PubMed:11137005). DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far (PubMed:11137005). ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (PubMed:11137005). As part of the ORC complex, might also have a role in mRNA export (Probable)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VFP4", "ec_number_list": [], "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000792 heterochromatin;GO:0005664 nuclear origin of replication recognition complex;GO:0005723 alpha-heterochromatin", "go_biological_process": "GO:0006260 DNA replication;GO:0007076 mitotic chromosome condensation;GO:0030261 chromosome condensation;GO:0006270 DNA replication initiation;GO:0007052 mitotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q24168-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24179-1", "uniprot_id": [ { "id": "SLY1_DROME", "url": "https://www.uniprot.org/uniprot/Q24179", "type": "external" } ], "mass": 72366.0, "length": 639, "protein_name": "Protein sly1 homolog", "gene_name": "Slh", "organism": "Fruit fly", "refseq_name": "SLY-1 homologous, isoform G", "refseq_ac": [ { "id": "NP_001137769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137769", "type": "external" } ], "gene_names_uniprotkb": "Slh; CG3539", "gene_names_refseq": "CG15393; CG3539; Dmel\\CG3539; SLH; SLY1; Slh; Sly1p; Sly1; Sly; d-sly; slh", "protein_names_uniprotkb": "Protein sly1 homolog", "protein_names_refseq": "CG3539-PG; SLY-1 homologous, isoform G; SLY1 homologous; Slh-PG", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3539); (R-DME-204005); (R-DME-8980692)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;8675012", "class_list": "", "function": "Non-vital for development., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B7YZZ1;B7YZZ2;O02560;Q4V684;Q7KU13;Q8SZB1;Q9VQC9", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0019905 syntaxin binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005798 Golgi-associated vesicle;GO:0005801 cis-Golgi network", "go_biological_process": "GO:0060628 regulation of ER to Golgi vesicle-mediated transport;GO:0006886 intracellular protein transport;GO:0001666 response to hypoxia;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0009636 response to toxic substance", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q24179-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24186-1", "uniprot_id": [ { "id": "RS5A_DROME", "url": "https://www.uniprot.org/uniprot/Q24186", "type": "external" } ], "mass": 25434.0, "length": 228, "protein_name": "Small ribosomal subunit protein uS7A", "gene_name": "RpS5a", "organism": "Fruit fly", "refseq_name": "ribosomal protein S5a, isoform B", "refseq_ac": [ { "id": "NP_001285360", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285360", "type": "external" } ], "gene_names_uniprotkb": "RpS5a; CG8922; Dmel\\CG8922; Dmel_CG8922; M(1)15D; M(1)15d; M(1)34i28; M(1)o; M[[o]]; RPS5a; RS5A_DROME; RS5; Rp S5a; RpS5; S5a; S7; rpS5; rps5a; rps5", "gene_names_refseq": "CG8922; Dmel\\CG8922; M(1)15D; M(1)15d; M(1)34i28; M(1)o; M[[o]]; RPS5a; RS5A_DROME; RS5; Rp S5a; RpS5a; RpS5; S5a; S7; rpS5; rps5a; rps5", "protein_names_uniprotkb": "Small ribosomal subunit protein uS7A; 40S ribosomal protein S5a", "protein_names_refseq": "CG8922-PB; Minute(1)15D; RpS5a-PB; minute 1(o); ribosomal protein S5 gene; ribosomal protein S5a, isoform B; ribosomal protein S5a; ribosomal protein S5; transcript e", "tax_id": 7227, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)", "pathway": " (dme:Dmel_CG8922); (R-DME-156827); (R-DME-1799339); (R-DME-6791226); (R-DME-72649); (R-DME-72689); (R-DME-72695); (R-DME-72702); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 13, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;23636399;25589440;26109356;26109357;8878687", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VX78", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome;GO:0003723 RNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005840 ribosome;GO:0022626 cytosolic ribosome;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0006412 translation;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q24186-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24212-1", "uniprot_id": [ { "id": "STNB_DROME", "url": "https://www.uniprot.org/uniprot/Q24212", "type": "external" } ], "mass": 137781.0, "length": 1262, "protein_name": "Protein stoned-B", "gene_name": "stnB", "organism": "Fruit fly", "refseq_name": "stoned B, isoform F", "refseq_ac": [ { "id": "NP_001036318", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036318", "type": "external" } ], "gene_names_uniprotkb": "stnB; CG12473; CG40306; Dmel\\CG12473; Dmel_CG12473; ORF2; STNB; StnB; stn-B; stn", "gene_names_refseq": "CG12473; CG40306; Dmel\\CG12473; ORF2; STNB; StnB; stn-B; stnB; stn", "protein_names_uniprotkb": "Protein stoned-B; Stn-B; StonedB", "protein_names_refseq": "CG12473-PF; StonedB; stnB-PF; stoned B, isoform F; stoned B; stoned-B; stoned", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12473); (R-DME-8856825); (R-DME-8856828)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "10407025;10731132;11069931;11160392;11312288;12537568;12537572;12537573;12537574;12907802;16110336;17569856;17569867;18327897;25589440;26109356;26109357;8844157", "class_list": "", "function": "Adapter protein involved in endocytic recycling of synaptic vesicles membranes. May act by mediating the retrieval of synaptotagmin protein Syt from the plasma membrane, thereby facilitating the internalization of multiple synaptic vesicles from the plasma membrane., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A4V4V9;Q7PLF4;Q9W5J3", "ec_number_list": [], "go_molecular_function": "GO:0097110 scaffold protein binding;GO:0035615 clathrin adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0048786 presynaptic active zone;GO:0030139 endocytic vesicle;GO:0030122 AP-2 adaptor complex;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0099504 synaptic vesicle cycle;GO:0030100 regulation of endocytosis;GO:0007268 chemical synaptic transmission;GO:0072583 clathrin-dependent endocytosis;GO:0048488 synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q24212-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24276-1", "uniprot_id": [ { "id": "CDC37_DROME", "url": "https://www.uniprot.org/uniprot/Q24276", "type": "external" } ], "mass": 45150.0, "length": 389, "protein_name": "Hsp90 co-chaperone Cdc37", "gene_name": "Cdc37", "organism": "Fruit fly", "refseq_name": "cell division cycle 37", "refseq_ac": [ { "id": "NP_477006", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477006", "type": "external" } ], "gene_names_uniprotkb": "Cdc37; CG12019; E(sev)3B", "gene_names_refseq": "CG12019; CPDR-1; CPDR-2; Cdc37; DROCPDR; Dmel\\CG12019; E(sev)3B; cdc37", "protein_names_uniprotkb": "Hsp90 co-chaperone Cdc37; Hsp90 chaperone protein kinase-targeting subunit; Protein enhancer of sevenless 3B", "protein_names_refseq": "CG12019-PA; Cdc37-PA; cdc37 protein; cell division cycle 37", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12019); (R-DME-114608); (R-DME-1227986); (R-DME-8863795); (R-DME-9013418); (R-DME-9652282)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "10731132;12374737;12537572;17372656;18327897;8020093", "class_list": "", "function": "Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Required for cytokinesis and chromosome segregation in mitosis and male meiosis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0019901 protein kinase binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0031072 heat shock protein binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007059 chromosome segregation;GO:0035556 intracellular signal transduction;GO:0051301 cell division;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q24276-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24297-1", "uniprot_id": [ { "id": "RUXF_DROME", "url": "https://www.uniprot.org/uniprot/Q24297", "type": "external" } ], "mass": 9739.0, "length": 88, "protein_name": "Small nuclear ribonucleoprotein F", "gene_name": "SmF", "organism": "Fruit fly", "refseq_name": "small ribonucleoprotein particle protein SmF", "refseq_ac": [ { "id": "NP_523708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523708", "type": "external" } ], "gene_names_uniprotkb": "SmF; CG16792; DebB", "gene_names_refseq": "BcDNA:GM23968; CG16792; Deb-B; DebB; Deb; Dmel\\CG16792; F-Sm; SmF; dF; deb-b; snRNP-F", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein F; Membrane-associated protein Deb-B; Sm protein F; Sm-F; SmF; snRNP-F", "protein_names_refseq": "CG16792-PA; SmF-PA; developmental embryonic B; small ribonucleoprotein particle protein SmF", "tax_id": 7227, "disease": "nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (dme:Dmel_CG16792); (R-DME-111367); (R-DME-72163); (R-DME-72165); (R-DME-73856); (R-DME-77588); (R-DME-9770562); (R-DME-9943411)", "pathway_count": 8, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;1694092;18621711", "class_list": "", "function": "Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9V672", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005829 cytosol;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome;GO:0034715 pICln-Sm protein complex", "go_biological_process": "GO:0036261 7-methylguanosine cap hypermethylation;GO:0000398 mRNA splicing, via spliceosome;GO:0071045 nuclear histone mRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q24297-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24319-1", "uniprot_id": [ { "id": "OST48_DROME", "url": "https://www.uniprot.org/uniprot/Q24319", "type": "external" } ], "mass": 49981.0, "length": 449, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit", "gene_name": "Ost48", "organism": "Fruit fly", "refseq_name": "oligosaccharyltransferase 48kD subunit", "refseq_ac": [ { "id": "NP_511096", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_511096", "type": "external" } ], "gene_names_uniprotkb": "Ost48; CG9022; OST50", "gene_names_refseq": "CG9022; DmOST50; Dmel\\CG9022; DrOST; OST48/WBP1; OST48; OST; Ost48; Ots48; anon-EST:Liang-1.11; clone 1.11; ost48", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; DDOST 48 kDa subunit; DmOST50; DrOST; OST5OP; Oligosaccharyl transferase 48 kDa subunit", "protein_names_refseq": "CG9022-PA; Ost48-PA; oligosaccaryltransferase 48kDa subunit; oligosaccharyltransferase 48kD subunit", "tax_id": 7227, "disease": "congenital disorder of glycosylation Ir (Disease Ontology:DOID:0080569)", "pathway": " (dme:Dmel_CG9022); (R-DME-6798695)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537572;7557364;7607543", "class_list": "", "function": "Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24355;Q9W382", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system;GO:0008250 oligosaccharyltransferase complex;GO:0160226 oligosaccharyltransferase complex A;GO:0160227 oligosaccharyltransferase complex B", "go_biological_process": "GO:0031647 regulation of protein stability;GO:0006487 protein N-linked glycosylation;GO:0180058 protein co-translational transfer of dolichol-linked oligosaccharide;GO:0180057 protein post-translational transfer of dolichol-linked oligosaccharide", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q24319-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24323-1", "uniprot_id": [ { "id": "SEM2A_DROME", "url": "https://www.uniprot.org/uniprot/Q24323", "type": "external" } ], "mass": 82998.0, "length": 724, "protein_name": "Semaphorin-2A", "gene_name": "Sema2a", "organism": "Fruit fly", "refseq_name": "semaphorin 2a, isoform A", "refseq_ac": [ { "id": "NP_477507", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477507", "type": "external" } ], "gene_names_uniprotkb": "Sema2a; CG4700; Sema-2a", "gene_names_refseq": "112/40; BcDNA:LD09561; CG4700; CT14922; D-Sema II; D-Sema-II; D-Sema2a; D-SemaII; D-semaII; Dmel\\CG4700; Dsema-II; Sema-2a; Sema2a; SemaII; dSema-II; l(2)03021; sema 2a; sema II; sema-2a; sema-II; sema2a; semaII", "protein_names_uniprotkb": "Semaphorin-2A; Sema II; Semaphorin-II", "protein_names_refseq": "CG4700-PA; D-Semaphorin II; Sema-2a; Sema2a-PA; semaphorin 2a, isoform A; semaphorin 2a; semaphorin II; semaphorin; semiphorin", "tax_id": 7227, "disease": "progressive familial intrahepatic cholestasis (Disease Ontology:DOID:0070221); childhood-onset asthma (Disease Ontology:DOID:0080815); hypogonadotropic hypogonadism 16 with or without anosmia (Disease Ontology:DOID:0090080); retinitis pigmentosa 35 (Disease Ontology:DOID:0110357); cone-rod dystrophy 10 (Disease Ontology:DOID:0111017); substance abuse (Disease Ontology:DOID:302); rheumatoid arthritis (Disease Ontology:DOID:7148); progressive myoclonus epilepsy (Disease Ontology:DOID:891)", "pathway": " (dme:Dmel_CG4700); (R-DME-416572); (R-DME-416700)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10731132;12537569;12537572;16672342;19349973;27618755;37041188;8269517", "class_list": "", "function": "Ligand for transmembrane receptor PlexB (PubMed:16672342). Plays a role in growth cone guidance (PubMed:27618755, PubMed:8269517). Required for both proper adult behavior and survival (PubMed:37041188, PubMed:8269517). Can function as a selective target-derived signal that inhibits the formation of specific synaptic terminal arbors (PubMed:8269517). Function in neurons is essential for adult survival, motor neuron survival, and is important for climbing behavior and activity (PubMed:37041188). During embryogenesis, plays an important role in correct salivary gland positioning (PubMed:27618755)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 3, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 8, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q0E954;Q6NN47;Q7KRC9;Q8MLF1;Q9V7Q7", "ec_number_list": [], "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0030534 adult behavior;GO:0071526 semaphorin-plexin signaling pathway;GO:0001755 neural crest cell migration;GO:0042756 drinking behavior", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q24323-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24368-1", "uniprot_id": [ { "id": "ISWI_DROME", "url": "https://www.uniprot.org/uniprot/Q24368", "type": "external" } ], "mass": 118873.0, "length": 1027, "protein_name": "Chromatin-remodeling complex ATPase chain Iswi", "gene_name": "Iswi", "organism": "Fruit fly", "refseq_name": "imitation SWI, isoform A", "refseq_ac": [ { "id": "NP_523719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523719", "type": "external" } ], "gene_names_uniprotkb": "Iswi; CG8625", "gene_names_refseq": "ACF; CG8625; CHRAC; Dmel\\CG8625; ISWI; ISW; Iswi; NURF 140; NURF-140; NURF; Nurf-140; SWI; anon-EP1279744.124; dCHRAC; dISWI; dNURF; iswi; p140/ISWI; p140", "protein_names_uniprotkb": "Chromatin-remodeling complex ATPase chain Iswi; 3.6.4.-; CHRAC 140 kDa subunit; NURF-140; Nucleosome-remodeling factor 140 kDa subunit; Protein imitation swi", "protein_names_refseq": "CG8625-PA; ISWI ATPase; Iswi-PA; imitation SWI, isoform A; imitation SWI; imitation SW; imitation switch; imitation-SWI; nucleosome remodeling factor - 140kD", "tax_id": 7227, "disease": "central nervous system disease (Disease Ontology:DOID:331)", "pathway": " (dme:Dmel_CG8625)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;10856248;11447119;12502740;12537569;12537572;14536084;16264191;18327897;28604694;7908117;8521501;8521502", "class_list": "", "function": "Energy-transducing component of the chromatin-remodeling complexes NURF (nucleosome-remodeling factor), ACF (ATP-utilizing chromatin assembly and remodeling factor), and CHRAC (chromatin accessibility complex) (PubMed:10856248, PubMed:11447119). NURF catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. It is required for homeotic gene expression, proper larval blood cell development, normal male X chromosome morphology, ecdysteroid signaling and metamorphosis (PubMed:12502740, PubMed:16264191, PubMed:8521501, PubMed:8521502)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A4UZF0;B5X0J3;Q0E9A4;Q8SX14;Q9V6E8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0000166 nucleotide binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0000785 chromatin;GO:0016589 NURF complex;GO:0031213 RSF complex", "go_biological_process": "GO:0034728 nucleosome organization;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q24368-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24371-1", "uniprot_id": [ { "id": "L2DTL_DROME", "url": "https://www.uniprot.org/uniprot/Q24371", "type": "external" } ], "mass": 84118.0, "length": 769, "protein_name": "Protein lethal(2)denticleless", "gene_name": "l(2)dtl", "organism": "Fruit fly", "refseq_name": "lethal-(2)-denticleless", "refseq_ac": [ { "id": "NP_524871", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524871", "type": "external" } ], "gene_names_uniprotkb": "l(2)dtl; CG11295; DTL83", "gene_names_refseq": "CG11295; Cdt2; DTL83; Dmel\\CG11295; L2DTL; cdt2; l(2)dtl", "protein_names_uniprotkb": "Protein lethal(2)denticleless; Protein DTL83", "protein_names_refseq": "CG11295-PA; l(2)dtl-PA; lethal-(2)-denticleless", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11295); (R-DME-110314); (R-DME-8951664)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10731132;12537569;12537572;17372656;18327897;19081076;8666267", "class_list": "", "function": "Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of E2f during S phase. E2f degradation is necessary to ensure proper development. Substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, leading to recruit the DCX(DTL) complex., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9W1K9", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0007095 mitotic G2 DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q24371-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24418-1", "uniprot_id": [ { "id": "NMDA1_DROME", "url": "https://www.uniprot.org/uniprot/Q24418", "type": "external" } ], "mass": 112288.0, "length": 997, "protein_name": "Glutamate [NMDA] receptor subunit 1", "gene_name": "Nmdar1", "organism": "Fruit fly", "refseq_name": "NMDA receptor 1", "refseq_ac": [ { "id": "NP_730940", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_730940", "type": "external" } ], "gene_names_uniprotkb": "Nmdar1; CG2902; NR1; nmr", "gene_names_refseq": "CG2902; DMNMDAR1; DNMDAR-I; DNmdar; DmelNmdar1; Dmel\\CG2902; DrNR1; NMDA R1; NMDA-R1; NMDAR1; NMDAR; NMDA; NMdar1; NR1; NRI; NmdaR1; Nmdar1; Nmdar; dNR1; dnmdar-I; dsNR1; nmdar1; nmr; nr1", "protein_names_uniprotkb": "Glutamate [NMDA] receptor subunit 1; DNMDAR-I; dNR1", "protein_names_refseq": "CG2902-PA; NMDA receptor 1; NMDA receptor I; NMDA receptor; NMDAR; Nmdar1-PA; dNR1", "tax_id": 7227, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal dominant neurodevelopmental disorder with or without hyperkinetic movements and seizures (Disease Ontology:DOID:0070038); developmental and epileptic encephalopathy 101 (Disease Ontology:DOID:0070387); Alzheimer's disease (Disease Ontology:DOID:10652); opioid abuse (Disease Ontology:DOID:11206); sciatic neuropathy (Disease Ontology:DOID:11446); neurodegenerative disease (Disease Ontology:DOID:1289); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); placental insufficiency (Disease Ontology:DOID:3891); schizophrenia (Disease Ontology:DOID:5419); vascular dementia (Disease Ontology:DOID:8725)", "pathway": " (dme:Dmel_CG2902); (R-DME-3928662); (R-DME-438066); (R-DME-8849932); (R-DME-9609736)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "10731132;11773617;12537569;12537572;15823532;17893096;8508917", "class_list": "", "function": "NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. Plays a role in associative learning and in long-term memory consolidation., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0038023 signaling receptor activity;GO:0004972 NMDA glutamate receptor activity", "go_cellular_component": "GO:0017146 NMDA selective glutamate receptor complex;GO:0008328 ionotropic glutamate receptor complex;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0016020 membrane", "go_biological_process": "GO:0050975 sensory perception of touch;GO:0008306 associative learning;GO:0035235 ionotropic glutamate receptor signaling pathway;GO:0042391 regulation of membrane potential;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q24418-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24434-1", "uniprot_id": [ { "id": "ORD_DROME", "url": "https://www.uniprot.org/uniprot/Q24434", "type": "external" } ], "mass": 55166.0, "length": 479, "protein_name": "Protein ORD", "gene_name": "ord", "organism": "Fruit fly", "refseq_name": "orientation disruptor, isoform B", "refseq_ac": [ { "id": "NP_001286760", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286760", "type": "external" } ], "gene_names_uniprotkb": "ord; CG3134", "gene_names_refseq": "CG3134; Dmel\\CG3134; ORD; Ord; ord", "protein_names_uniprotkb": "Protein ORD; Orientation disrupter protein", "protein_names_refseq": "CG3134-PB; ord-PB; orientation disrupter; orientation disruptor, isoform B; orientation disruptor", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3134)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12062057;12429833;12537572;14669021;8635478", "class_list": "", "function": "Essential for proper maintenance of sister-chromatid cohesion in both male and female meiosis. Mutations in ord cause premature separation of the sister chromatids in meiosis I and random segregation in both meiotic divisions. Required for chiasma maintenance in female meiosis. Mutations in ord reduce recombination in female meiosis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W1S8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0001673 male germ cell nucleus;GO:0000785 chromatin;GO:0000779 condensed chromosome, centromeric region", "go_biological_process": "GO:0007060 male meiosis chromosome segregation;GO:0007066 female meiosis sister chromatid cohesion;GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation;GO:0051457 maintenance of protein location in nucleus", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q24434-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24437-1", "uniprot_id": [ { "id": "MST40_DROME", "url": "https://www.uniprot.org/uniprot/Q24437", "type": "external" } ], "mass": 2724.0, "length": 23, "protein_name": "Protein male-specific 40", "gene_name": "Mst40", "organism": "Fruit fly", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mst40", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein male-specific 40", "protein_names_refseq": "", "tax_id": 7227, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "10731132;12537572;8013257", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q24437-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24475-1", "uniprot_id": [ { "id": "RPR_DROME", "url": "https://www.uniprot.org/uniprot/Q24475", "type": "external" } ], "mass": 7682.0, "length": 65, "protein_name": "Cell death protein rpr", "gene_name": "rpr", "organism": "Fruit fly", "refseq_name": "reaper", "refseq_ac": [ { "id": "NP_524138", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524138", "type": "external" } ], "gene_names_uniprotkb": "rpr; CG4319", "gene_names_refseq": "CG4319; Dmel\\CG4319; RPR; Reaper; Rpr; anon-WO0162936.19; rpr; rp", "protein_names_uniprotkb": "Cell death protein rpr; Protein reaper", "protein_names_refseq": "CG4319-PA; reaper L; reaper; rpr-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4319)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10731132;12537572;18166655;19252929;25307481;8171319;9740659", "class_list": "", "function": "Activator of apoptosis, as well as grim and hid, that acts on the effector Dredd., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JQ43;Q4V3S2;Q9VVP7", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0042803 protein homodimerization activity;GO:0031625 ubiquitin protein ligase binding;GO:0031624 ubiquitin conjugating enzyme binding;GO:1990948 ubiquitin ligase inhibitor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0046330 positive regulation of JNK cascade;GO:0051402 neuron apoptotic process;GO:0006915 apoptotic process;GO:0097190 apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q24475-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24488-1", "uniprot_id": [ { "id": "ROR1_DROME", "url": "https://www.uniprot.org/uniprot/Q24488", "type": "external" } ], "mass": 78143.0, "length": 685, "protein_name": "Tyrosine-protein kinase transmembrane receptor Ror", "gene_name": "Ror", "organism": "Fruit fly", "refseq_name": "Ror", "refseq_ac": [ { "id": "NP_476962", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476962", "type": "external" } ], "gene_names_uniprotkb": "Ror; CG4926", "gene_names_refseq": "CG4926; DRor; DmHD-2; Dmel\\CG4926; Dror; HD-2; ROR-alpha; ROR1; ROR; Ror", "protein_names_uniprotkb": "Tyrosine-protein kinase transmembrane receptor Ror; 2.7.10.1; dRor", "protein_names_refseq": "CG4926-PA; RTK-like orphan receptors; Ror-PA; Ror", "tax_id": 7227, "disease": "autosomal recessive Robinow syndrome (Disease Ontology:DOID:0060764); autosomal recessive nonsyndromic deafness 108 (Disease Ontology:DOID:0080263); brachydactyly type B1 (Disease Ontology:DOID:0110969); cleft palate (Disease Ontology:DOID:674)", "pathway": " (dme:Dmel_CG4926); (R-DME-5140745)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;12537572;18327897;8394009;9731193", "class_list": "", "function": "Tyrosine-protein kinase receptor that functions during early stages of neuronal development., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0017147 Wnt-protein binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0043235 receptor complex", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007417 central nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q24488-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24498-2", "uniprot_id": [ { "id": "RYR_DROME", "url": "https://www.uniprot.org/uniprot/Q24498", "type": "external" } ], "mass": 581012.0, "length": 5127, "protein_name": "Ryanodine receptor", "gene_name": "RyR", "organism": "Fruit fly", "refseq_name": "ryanodine receptor, isoform A", "refseq_ac": [ { "id": "NP_476991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476991", "type": "external" } ], "gene_names_uniprotkb": "RyR; CG10844; Rya-r44F; dry", "gene_names_refseq": "CG10844; D-RyR; DRR; DRY; DmRyR; Dmel\\CG10844; RYR; RyRs; RyR; Rya-44F; Rya-R44F; Rya-r44F; Rya-r4; Rya-r76CD; Ryr; dRyR; dRyr; dry; dya; l(2)k00424; l(2)k04913; rya-r44F; ryr", "protein_names_uniprotkb": "Ryanodine receptor; Ryanodine receptor 44F", "protein_names_refseq": "CG10844-PA; RyR-PA; RyanodineR; ryanodine receptor 44F; ryanodine receptor, isoform A; ryanodine receptor", "tax_id": 7227, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); catecholaminergic polymorphic ventricular tachycardia 1 (Disease Ontology:DOID:0060675); King Denborough syndrome (Disease Ontology:DOID:0080990); congenital myopathy 1B (Disease Ontology:DOID:0080991); congenital myopathy 20 (Disease Ontology:DOID:0081352); pre-eclampsia (Disease Ontology:DOID:10591); heart disease (Disease Ontology:DOID:114); gestational diabetes (Disease Ontology:DOID:11714); intracranial vasospasm (Disease Ontology:DOID:13100); primary pulmonary hypertension (Disease Ontology:DOID:14557); alcohol use disorder (Disease Ontology:DOID:1574); osteochondrodysplasia (Disease Ontology:DOID:2256); congenital myopathy 1A (Disease Ontology:DOID:3529); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); malignant hyperthermia (Disease Ontology:DOID:8545)", "pathway": " (dme:Dmel_CG10844)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;10811919;12537572;1338312;18327897;8276118", "class_list": "", "function": "Intracellular calcium channel that is required for proper muscle function during embryonic development and may be essential for excitation-contraction coupling in larval body wall muscles., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q24321;Q24499;Q24500;Q24501;Q8MKS3;Q8MKS4;Q8MKS5;Q9V4Y7", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005219 ryanodine-sensitive calcium-release channel activity;GO:0015279 store-operated calcium channel activity", "go_cellular_component": "GO:0016020 membrane;GO:0033017 sarcoplasmic reticulum membrane", "go_biological_process": "GO:0006936 muscle contraction;GO:0006816 calcium ion transport;GO:0006874 intracellular calcium ion homeostasis;GO:0060047 heart contraction;GO:0051209 release of sequestered calcium ion into cytosol", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q24498-2", "record_type": "protein", "filter_code": "0000000.0000111.000100.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24546-1", "uniprot_id": [ { "id": "SYN_DROME", "url": "https://www.uniprot.org/uniprot/Q24546", "type": "external" } ], "mass": 103014.0, "length": 981, "protein_name": "Synapsin", "gene_name": "Syn", "organism": "Fruit fly", "refseq_name": "synapsin, isoform A", "refseq_ac": [ { "id": "NP_731457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_731457", "type": "external" } ], "gene_names_uniprotkb": "Syn; CG3985; Syn-1; Syn-2", "gene_names_refseq": "CG3985; Dmel\\CG3985; Dsyn-1; SYN1; SYN2; SYN; Syn; synapsin; syn", "protein_names_uniprotkb": "Synapsin; Syn1-S", "protein_names_refseq": "CG3985-PA; Syn-PA; Synapsin1; synapsin I; synapsin, isoform A; synapsin", "tax_id": 7227, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); non-syndromic X-linked intellectual disability 50 (Disease Ontology:DOID:0112029); X-linked epilepsy with variable learning disabilities and behavior disorders (Disease Ontology:DOID:0112122); major depressive disorder (Disease Ontology:DOID:1470); epilepsy (Disease Ontology:DOID:1826); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dme:Dmel_CG3985); (R-DME-181429); (R-DME-212676)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10731132;12537572;15255973;18327897;21994247;29568072;33925313;8627354", "class_list": "", "function": "Plays a significant role in nervous system function, which is subtle at the cellular level but manifests itself in complex behavior., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E2QCY9;E2QCZ0;Q24544;Q24545;Q5BIE8;Q86BA0;Q8INM4;Q8INM6", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding", "go_cellular_component": "GO:0043195 terminal bouton;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0008049 male courtship behavior;GO:0072553 terminal button organization;GO:0097091 synaptic vesicle clustering;GO:0007613 memory;GO:0008306 associative learning", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q24546-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27272-1", "uniprot_id": [ { "id": "TAF9_DROME", "url": "https://www.uniprot.org/uniprot/Q27272", "type": "external" } ], "mass": 29314.0, "length": 278, "protein_name": "Transcription initiation factor TFIID subunit 9", "gene_name": "Taf9", "organism": "Fruit fly", "refseq_name": "TBP-associated factor 9", "refseq_ac": [ { "id": "NP_523391", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523391", "type": "external" } ], "gene_names_uniprotkb": "Taf9; CG6474; TAF40; TAFII40; e(y)1", "gene_names_refseq": "CG6474; Dmel\\CG6474; E(y)1; TAF40/42/e(y)1; TAF40/42; TAF40; TAF42; TAF9; TAFII40(42); TAFII40; TAF[II]40; TAF[[II]]40/42; TAF[[II]]40; TAF[[II]]42; TAF[[II]]; TFIID 42; TFIID-p42; TFIID; Taf40; Taf42; Taf9; TafII40; Taf[[II]]40; d40; dTAF42; dTAF9; dTAFII42; dTAF[[40]]; dTAF[[II]]40; dTAF[[II]]42; dTaf9; dmTAF9; dmTaf9; dme-TAFII40; e(y)1; e(y)4; e(y)[1]; p42; taf40/e(y)1; taf9", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 9; Protein enhancer of yellow 1; TAFII-42; TBP-associated factor 9; Transcription initiation factor TFIID 42 kDa subunit; p42", "protein_names_refseq": "CG6474-PA; TBP-associated factor 40kD; TBP-associated factor 9; TBP-associated factor; Taf9-PA; enhancer of yellow 1; enhancer of yellow 4", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6474); (R-DME-5689880); (R-DME-674695); (R-DME-6804756); (R-DME-6807505); (R-DME-73776); (R-DME-73779); (R-DME-75953); (R-DME-76042)", "pathway_count": 9, "publication_count": 6, "publication_id_list": "10731132;11438676;12537572;7545910;8221891;8598927", "class_list": "", "function": "TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95RJ4;Q9VX16", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0046982 protein heterodimerization activity;GO:0001223 transcription coactivator binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005669 transcription factor TFIID complex;GO:0000124 SAGA complex", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0051123 RNA polymerase II preinitiation complex assembly;GO:0030707 follicle cell of egg chamber development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q27272-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27350-1", "uniprot_id": [ { "id": "SO_DROME", "url": "https://www.uniprot.org/uniprot/Q27350", "type": "external" } ], "mass": 45025.0, "length": 416, "protein_name": "Protein sine oculis", "gene_name": "so", "organism": "Fruit fly", "refseq_name": "sine oculis", "refseq_ac": [ { "id": "NP_476733", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476733", "type": "external" } ], "gene_names_uniprotkb": "so; CG11121", "gene_names_refseq": "CG11121; Dmel\\CG11121; Drl; SO; Sine oculis; So; ami; mda; med; old; soD; somda; so", "protein_names_uniprotkb": "Protein sine oculis", "protein_names_refseq": "CG11121-PA; absent minded; droplet; medusa; optic lobe defective; sine oculis; sine oculus; sinus oculis; so-PA", "tax_id": 7227, "disease": "branchiootic syndrome 3 (Disease Ontology:DOID:0061210); autosomal dominant nonsyndromic deafness 23 (Disease Ontology:DOID:0110553); branchiootorenal syndrome (Disease Ontology:DOID:14702); breast cancer (Disease Ontology:DOID:1612); nephroblastoma (Disease Ontology:DOID:2154); neurilemmoma (Disease Ontology:DOID:3192); ovarian carcinoma (Disease Ontology:DOID:4001); renal Wilms' tumor (Disease Ontology:DOID:5176); cleft palate (Disease Ontology:DOID:674); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (dme:Dmel_CG11121)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;7896096;7910468", "class_list": "", "function": "Required for visual system development. May transcriptionally regulate genes necessary for optic lobe invagination and Bolwig's nerve formation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AVT8;Q9V4L0", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001223 transcription coactivator binding;GO:0001222 transcription corepressor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0048749 compound eye development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q27350-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2MGL3-1", "uniprot_id": [ { "id": "POP7_DROME", "url": "https://www.uniprot.org/uniprot/Q2MGL3", "type": "external" } ], "mass": 18876.0, "length": 167, "protein_name": "Ribonuclease P protein subunit p20", "gene_name": "Rpp20", "organism": "Fruit fly", "refseq_name": "ribonuclease P protein subunit p20, isoform A", "refseq_ac": [ { "id": "NP_001027078", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027078", "type": "external" } ], "gene_names_uniprotkb": "Rpp20; BcDNA:RE70209; CG12533; CG32530-ORFA; CG32530; CG33931; Dmel\\CG33931; Dmel_CG33931; Pop7; dRpp20", "gene_names_refseq": "BcDNA:RE70209; CG12533; CG32530-ORFA; CG32530; CG33931; Dmel\\CG33931; Pop7; Rpp20; dRpp20", "protein_names_uniprotkb": "Ribonuclease P protein subunit p20; RNaseP protein p20", "protein_names_refseq": "CG33931-PA; Rpp20-PA; ribonuclease P protein subunit p20, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33931)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;14715275;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP complex, which cleaves pre-rRNA sequences (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C0PUX7", "ec_number_list": [], "go_molecular_function": "GO:0033204 ribonuclease P RNA binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005655 nucleolar ribonuclease P complex;GO:0030681 multimeric ribonuclease P complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000172 ribonuclease MRP complex", "go_biological_process": "GO:0006396 RNA processing;GO:0008033 tRNA processing;GO:0006364 rRNA processing;GO:0001682 tRNA 5'-leader removal", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q2MGL3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32KD2-1", "uniprot_id": [ { "id": "SETB1_DROME", "url": "https://www.uniprot.org/uniprot/Q32KD2", "type": "external" } ], "mass": 141946.0, "length": 1262, "protein_name": "Histone-lysine N-methyltransferase eggless", "gene_name": "egg", "organism": "Fruit fly", "refseq_name": "eggless", "refseq_ac": [ { "id": "NP_611966", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611966", "type": "external" } ], "gene_names_uniprotkb": "egg; CG12196", "gene_names_refseq": "AAF47268 Dm; AAM70794; BcDNA:AT13877; CG12196; CG30422; CG30426; Dm-setdb1; DmSETDB1; DmSetdb1; Dmel\\CG12196; Dmsetdb1; EGG; Eggless; Egg; SETDB1; SetDB1; Setdb1; dEset; dSETDB1; dSetDB1; dSetdb1; dsetdb1; egg; setdb1", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase eggless; 2.1.1.355; SETDB1 homolog", "protein_names_refseq": "CG12196-PA; Histone-lysine N-methyltransferase; dSETDB1; egg-PA; eggless", "tax_id": 7227, "disease": "prostate cancer (Disease Ontology:DOID:10283); autistic disorder (Disease Ontology:DOID:12849); Huntington's disease (Disease Ontology:DOID:12858); lung cancer (Disease Ontology:DOID:1324); melanoma (Disease Ontology:DOID:1909); high grade glioma (Disease Ontology:DOID:3070); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dme:Dmel_CG12196); (R-DME-3214841); (R-DME-9843940)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;17164421;18327897;37027460", "class_list": "", "function": "Histone methyltransferase that specifically trimethylates 'Lys-10' of histone H3 (H3K9me3) in ovary (PubMed:17164421). H3K9me3 represents a specific tag for epigenetic transcriptional repression by recruiting Su(var)205/HP1 to methylated histones (PubMed:17164421). Plays a central role during oogenesis (PubMed:17164421)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q29QW7;Q8IHC9;Q8MMD1;Q960X1;Q9W110", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0046974 histone H3K9 methyltransferase activity;GO:0140947 histone H3K9me2 methyltransferase activity;GO:0140949 histone H3K9 trimethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005700 polytene chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0010629 negative regulation of gene expression;GO:0032259 methylation;GO:0040029 epigenetic regulation of gene expression;GO:0048477 oogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q32KD2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4LBB6-6", "uniprot_id": [ { "id": "OCTB3_DROME", "url": "https://www.uniprot.org/uniprot/Q4LBB6", "type": "external" } ], "mass": 136370.0, "length": 1256, "protein_name": "Octopamine receptor beta-3R", "gene_name": "Octbeta3R", "organism": "Fruit fly", "refseq_name": "octopamine beta3 receptor, isoform J", "refseq_ac": [ { "id": "NP_001034043", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034043", "type": "external" } ], "gene_names_uniprotkb": "Octbeta3R; CG42244; Oct-beta-3", "gene_names_refseq": "CG18554; CG31348; CG31350; CG31351; CG33959; CG34055; CG42244; CG7078; DmCG7078; DmOctbeta3R; Dmel\\CG42244; OctBeta3; Octb3R; Octbeta3R; anon-WO0170980.187; anon-WO0170980.188; octRbeta3; octbeta3R; octbeta3r", "protein_names_uniprotkb": "Octopamine receptor beta-3R; DmOct-beta-3R", "protein_names_refseq": "CG42244-PJ; Octbeta3R-PJ; octopamine beta3 receptor, isoform J; octopamine receptor beta3", "tax_id": 7227, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); obstructive sleep apnea (Disease Ontology:DOID:0050848); colitis (Disease Ontology:DOID:0060180); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); childhood-onset asthma (Disease Ontology:DOID:0080815); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); Alzheimer's disease (Disease Ontology:DOID:10652); open-angle glaucoma (Disease Ontology:DOID:1067); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); pulmonary edema (Disease Ontology:DOID:11396); polycystic ovary syndrome (Disease Ontology:DOID:11612); nephrosclerosis (Disease Ontology:DOID:11664); Graves' disease (Disease Ontology:DOID:12361); dilated cardiomyopathy (Disease Ontology:DOID:12930); gout (Disease Ontology:DOID:13189); low tension glaucoma (Disease Ontology:DOID:13544); endometrial cancer (Disease Ontology:DOID:1380); familial hypercholesterolemia (Disease Ontology:DOID:13810); interstitial cystitis (Disease Ontology:DOID:13949); toxic shock syndrome (Disease Ontology:DOID:14115); hypothyroidism (Disease Ontology:DOID:1459); cystic fibrosis (Disease Ontology:DOID:1485); urticaria (Disease Ontology:DOID:1555); renovascular hypertension (Disease Ontology:DOID:1591); aortic valve stenosis (Disease Ontology:DOID:1712); dermatitis (Disease Ontology:DOID:2723); asthma (Disease Ontology:DOID:2841); bronchiolitis (Disease Ontology:DOID:2942); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); hyperglycemia (Disease Ontology:DOID:4195); myasthenia gravis (Disease Ontology:DOID:437); cholangiocarcinoma (Disease Ontology:DOID:4947); pneumonia (Disease Ontology:DOID:552); kidney disease (Disease Ontology:DOID:557); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); myocarditis (Disease Ontology:DOID:820); periodontitis (Disease Ontology:DOID:824); ulcerative colitis (Disease Ontology:DOID:8577); anorexia nervosa (Disease Ontology:DOID:8689); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG42244); (R-DME-390651); (R-DME-390696); (R-DME-418555); (R-DME-5689880); (R-DME-8856825); (R-DME-8856828)", "pathway_count": 7, "publication_count": 5, "publication_id_list": "10731132;12537572;15998303;22303848;25605909", "class_list": "", "function": "Autoreceptor for octopamine, which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates (By similarity). Probably also acts as a receptor for tyramine during ecdysone biosynthesis (PubMed:25605909). Required for the biosynthesis of the steroid hormone ecdysone which is necessary for metamorphosis (PubMed:25605909). Involved in activation of prothoracicotropic hormone and insulin-like peptide signaling which is required for the expression of ecdysone biosynthetic genes (PubMed:25605909)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 51, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A0AVV1;Q2PDR1;Q2PDR2;Q2PDR3;Q2PDR4;Q2PDR5;Q2PDR6;Q4LBB5;Q4LBB7;Q4LBB8;Q8INI6;Q8INI7;Q9VG56;Q9VG57", "ec_number_list": [], "go_molecular_function": "GO:0008227 G protein-coupled amine receptor activity;GO:0004989 octopamine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0043410 positive regulation of MAPK cascade;GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q4LBB6-6", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V5I9-1", "uniprot_id": [ { "id": "SDF2A_DROME", "url": "https://www.uniprot.org/uniprot/Q4V5I9", "type": "external" } ], "mass": 19194.0, "length": 163, "protein_name": "Succinate dehydrogenase assembly factor 2-A, mitochondrial", "gene_name": "CG14757", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_610363", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610363", "type": "external" } ], "gene_names_uniprotkb": "CG14757", "gene_names_refseq": "146793_at; CG14757; Dmel\\CG14757", "protein_names_uniprotkb": "Succinate dehydrogenase assembly factor 2-A, mitochondrial; SDH assembly factor 2-A; SDHAF2-A", "protein_names_refseq": "CG14757-PA; uncharacterized protein", "tax_id": 7227, "disease": "pheochromocytoma/paraganglioma syndrome 2 (Disease Ontology:DOID:0061217)", "pathway": " (dme:Dmel_CG14757); (R-DME-9854311)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005507 copper ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0055070 copper ion homeostasis;GO:0006121 mitochondrial electron transport, succinate to ubiquinone;GO:0018293 protein-FAD linkage;GO:0034553 mitochondrial respiratory chain complex II assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4V5I9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V5R4-1", "uniprot_id": [ { "id": "POLYP_DROME", "url": "https://www.uniprot.org/uniprot/Q4V5R4", "type": "external" } ], "mass": 52035.0, "length": 460, "protein_name": "Glutamate transporter polyphemus", "gene_name": "polyph", "organism": "Fruit fly", "refseq_name": "polyphemus, isoform C", "refseq_ac": [ { "id": "NP_001286301", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286301", "type": "external" } ], "gene_names_uniprotkb": "polyph; CG12943", "gene_names_refseq": "CG12943; Dmel\\CG12943; polyph", "protein_names_uniprotkb": "Glutamate transporter polyphemus", "protein_names_refseq": "CG12943-PC; polyph-PC; polyphemus, isoform C", "tax_id": 7227, "disease": "iminoglycinuria (Disease Ontology:DOID:0112265)", "pathway": " (dme:Dmel_CG12943); (R-DME-352230); (R-DME-428559); (R-DME-71240)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10731132;12537572;24210616", "class_list": "", "function": "Probable glutamate transporter which transports extracellular glutamate into the cells. Regulates the production of intracellular reactive oxygen species (ROS) probably by controlling the synthesis of antioxidant glutathione. By regulating ROS production in blood cells, required for maintaining bacteria phagocytosis following infection with S.aureus and possibly E.coli., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4LG39", "ec_number_list": [], "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity;GO:0015171 amino acid transmembrane transporter activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005774 vacuolar membrane", "go_biological_process": "GO:0007320 insemination;GO:0006909 phagocytosis;GO:0042742 defense response to bacterium;GO:0003333 amino acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q4V5R4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q94918-1", "uniprot_id": [ { "id": "VEIN_DROME", "url": "https://www.uniprot.org/uniprot/Q94918", "type": "external" } ], "mass": 71698.0, "length": 623, "protein_name": "Protein vein", "gene_name": "vn", "organism": "Fruit fly", "refseq_name": "vein, isoform A", "refseq_ac": [ { "id": "NP_523942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523942", "type": "external" } ], "gene_names_uniprotkb": "vn; CG10491; CT29452; Dm vn; Dmel\\CG10491; Dmel_CG10491; P1749; Vein; Vn; ddd; l(3)10567; l(3)10568; l(3)L6A; l(3)ddd; l(3)rF264; l(3)vn10567; wvn", "gene_names_refseq": "CG10491; CT29452; Dm vn; Dmel\\CG10491; P1749; Vein; Vn; ddd; l(3)10567; l(3)10568; l(3)L6A; l(3)ddd; l(3)rF264; l(3)vn10567; vn; wvn", "protein_names_uniprotkb": "Protein vein; Epidermal growth factor-like protein; Protein defective dorsal discs", "protein_names_refseq": "CG10491-PA; Dm vein; defective dorsal discs; vein, isoform A; vein; vn-PA", "tax_id": 7227, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); obstructive sleep apnea (Disease Ontology:DOID:0050848); schizophrenia 6 (Disease Ontology:DOID:0070082); overactive bladder syndrome (Disease Ontology:DOID:0070355); amblyopia (Disease Ontology:DOID:10376); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); Alzheimer's disease (Disease Ontology:DOID:10652); sciatic neuropathy (Disease Ontology:DOID:11446); dementia (Disease Ontology:DOID:1307); interstitial cystitis (Disease Ontology:DOID:13949); cerebral malaria (Disease Ontology:DOID:14069); major depressive disorder (Disease Ontology:DOID:1470); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); cannabis dependence (Disease Ontology:DOID:1849); transient cerebral ischemia (Disease Ontology:DOID:224); ovarian cancer (Disease Ontology:DOID:2394); psychotic disorder (Disease Ontology:DOID:2468); substance abuse (Disease Ontology:DOID:302); bipolar disorder (Disease Ontology:DOID:3312); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); middle cerebral artery infarction (Disease Ontology:DOID:3525); tuberculosis (Disease Ontology:DOID:399); schizophrenia (Disease Ontology:DOID:5419); median neuropathy (Disease Ontology:DOID:571); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); neuropathy (Disease Ontology:DOID:870); cannabis abuse (Disease Ontology:DOID:9505); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (dme:Dmel_CG10491); (R-DME-1227986); (R-DME-1236394); (R-DME-1250196); (R-DME-1250342); (R-DME-1250347); (R-DME-1257604); (R-DME-1358803); (R-DME-1963640); (R-DME-1963642); (R-DME-5673001); (R-DME-6785631); (R-DME-6811558); (R-DME-8863795)", "pathway_count": 14, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8824589", "class_list": "", "function": "Ligand for the EGF receptor. Seems to play a role in the global proliferation of wing disc cells and the larval patterning. Shows a strong synergistic genetic interaction with spi, suggesting a molecular interdependence. Required for the development of interveins cells., [UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 31, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q9VRQ3", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008201 heparin binding;GO:0005154 epidermal growth factor receptor binding;GO:0008083 growth factor activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0038127 ERBB signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0035556 intracellular signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q94918-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q59E36-2", "uniprot_id": [ { "id": "RCOR_DROME", "url": "https://www.uniprot.org/uniprot/Q59E36", "type": "external" } ], "mass": 62696.0, "length": 590, "protein_name": "REST corepressor", "gene_name": "CoRest", "organism": "Fruit fly", "refseq_name": "CoRest, isoform F", "refseq_ac": [ { "id": "NP_001014752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014752", "type": "external" } ], "gene_names_uniprotkb": "CoRest; CG33525", "gene_names_refseq": "BcDNA:GH01486; BcDNA:LD11215; CG32534; CG32535; CG33525; CG3878; CG42687; CoRESTG; CoREST; CoRest; Dmel\\CG42687; dCoREST; i169", "protein_names_uniprotkb": "REST corepressor; CoREST", "protein_names_refseq": "CG42687-PF; CoRest, isoform F; CoRest-PF", "tax_id": 7227, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (dme:Dmel_CG42687); (R-DME-3214815); (R-DME-983231)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;15306652;17372656;18327897", "class_list": "", "function": "Essential component of a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited by Ttk88 and probably acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. May serve as a molecular beacon for the recruitment of molecular machinery that imposes silencing across a chromosomal interval., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V4S3;Q494F9;Q59E35;Q8MSX7;Q95TC9;Q9VWH3", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0017053 transcription repressor complex;GO:0005667 transcription regulator complex;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0141006 transposable element silencing by piRNA-mediated heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q59E36-2", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5LJZ2-1", "uniprot_id": [ { "id": "SET1_DROME", "url": "https://www.uniprot.org/uniprot/Q5LJZ2", "type": "external" } ], "mass": 188383.0, "length": 1641, "protein_name": "Histone-lysine N-methyltransferase SETD1", "gene_name": "Set1", "organism": "Fruit fly", "refseq_name": "SET domain containing 1, isoform A", "refseq_ac": [ { "id": "NP_001015221", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015221", "type": "external" } ], "gene_names_uniprotkb": "Set1; CG40351", "gene_names_refseq": "CG17395; CG17396; CG40351; Dmel\\CG40351; SET1; SETD1; Set1; SetD1; aaf45425 Dm; dSET1; dSet-1; dSet1; dset1; l(3)h5; l5; set1", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase SETD1; 2.1.1.354", "protein_names_refseq": "CG40351-PA; SET domain containing 1, isoform A; SET domain-containing 1; Set1-PA; lethal 5; lethal5", "tax_id": 7227, "disease": "neurodevelopmental disorder with speech impairment and dysmorphic facies (Disease Ontology:DOID:0070417); early-onset epilepsy 2 (Disease Ontology:DOID:0070471); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dme:Dmel_CG40351); (R-DME-8936459); (R-DME-9772755)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10731132;12537572;21694722;21875999;22048023;26957542", "class_list": "", "function": "Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3 (PubMed:21694722, PubMed:21875999, PubMed:22048023). Binds RNAs which might negatively affect its histone methyltransferase activity (By similarity). COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face (By similarity). Set1-dependent trimethylation regulates chromatin changes at active promoters that ensure optimal RNA polymerase II release into productive elongation, thereby contributing to optimal transcription (PubMed:21694722)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "M9WDY6;Q4V706;Q8SXR9", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.370", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.370", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0042800 histone H3K4 methyltransferase activity;GO:0140999 histone H3K4 trimethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000791 euchromatin;GO:0048188 Set1C/COMPASS complex;GO:0005700 polytene chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5LJZ2-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AWN0-1", "uniprot_id": [ { "id": "MTND_DROME", "url": "https://www.uniprot.org/uniprot/Q6AWN0", "type": "external" } ], "mass": 22255.0, "length": 186, "protein_name": "Acireductone dioxygenase", "gene_name": "Adi1", "organism": "Fruit fly", "refseq_name": "acireductone dioxygenase 1", "refseq_ac": [ { "id": "NP_001097577", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097577", "type": "external" } ], "gene_names_uniprotkb": "Adi1; CG32068", "gene_names_refseq": "Adi1; CG32068; CG8000; Dadi1; Dmel\\CG32068; adi1", "protein_names_uniprotkb": "Acireductone dioxygenase; 1.13.11.53; 1.13.11.54; ARD'; ARD; Acireductone dioxygenase (Fe(2+)-requiring); Acireductone dioxygenase (Ni(2+)-requiring); Fe-ARD; Ni-ARD", "protein_names_refseq": "Adi1-PB; CG32068-PB; aci-reductone dioxygenase 1; acireductone dioxygenase 1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32068); (R-DME-1237112)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537572;25037729", "class_list": "", "function": "Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IQE4", "ec_number_list": [ { "id": "1.13.11.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.54", "type": "external" }, { "id": "1.13.11.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.53", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0016491 oxidoreductase activity;GO:0016151 nickel cation binding;GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity;GO:0010308 acireductone dioxygenase (Ni2+-requiring) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0019509 L-methionine salvage from methylthioadenosine;GO:0006555 methionine metabolic process;GO:0009086 methionine biosynthetic process;GO:2000243 positive regulation of reproductive process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6AWN0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IGX9-1", "uniprot_id": [ { "id": "SIFA_DROME", "url": "https://www.uniprot.org/uniprot/Q6IGX9", "type": "external" } ], "mass": 7901.0, "length": 72, "protein_name": "Neuropeptide SIFamide", "gene_name": "SIFa", "organism": "Fruit fly", "refseq_name": "SIFamide", "refseq_ac": [ { "id": "NP_001246496", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246496", "type": "external" } ], "gene_names_uniprotkb": "SIFa; CG33527; IFa", "gene_names_refseq": "CG33527; Dmel\\CG33527; Drm-IFa; Drm-SIFa; IFAMIDE; IFa; Neb-LFamide; SIFR; SIFa; SIF", "protein_names_uniprotkb": "Neuropeptide SIFamide", "protein_names_refseq": "AYRKPPFNGSLFamide; CG33527-PB; IFamide; Neb-LFamide; SIFa-PB; SIFamide; neuropeptide AYRKPPFNGSIFamide; neuropeptide IFamide", "tax_id": 7227, "disease": "tauopathy (Disease Ontology:DOID:680)", "pathway": " (dme:Dmel_CG33527)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10731132;12537572;14709175;15219831;16378592;17126293;24658384;26469541", "class_list": "", "function": "Ligand for the neuropeptide SIFamide receptor (PubMed:16378592). Modulates sexual behavior by negatively regulating female receptivity to male courtship and by playing a role in male sex discrimination (PubMed:17126293, PubMed:26469541). Also involved in promoting sleep (PubMed:24658384)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A8E6Z0;A8E728;B3DMR1;Q8IA34", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0005179 hormone activity;GO:0071855 neuropeptide receptor binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0060179 male mating behavior;GO:0007621 negative regulation of female receptivity;GO:0007218 neuropeptide signaling pathway;GO:0045938 positive regulation of circadian sleep/wake cycle, sleep;GO:0042752 regulation of circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6IGX9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NL34-1", "uniprot_id": [ { "id": "TCAB1_DROME", "url": "https://www.uniprot.org/uniprot/Q6NL34", "type": "external" } ], "mass": 60498.0, "length": 543, "protein_name": "Telomerase Cajal body protein 1 homolog", "gene_name": "WDR79", "organism": "Fruit fly", "refseq_name": "WD repeat domain 79, isoform C", "refseq_ac": [ { "id": "NP_001285665", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285665", "type": "external" } ], "gene_names_uniprotkb": "WDR79; CG9226", "gene_names_refseq": "CG9226; Dmel\\CG9226; WDR79; dWDR79; p70", "protein_names_uniprotkb": "Telomerase Cajal body protein 1 homolog; WD repeat-containing protein 79", "protein_names_refseq": "CG9226-PC; WD repeat domain 79 homolog; WD repeat domain 79, isoform C; WDR79-PC", "tax_id": 7227, "disease": "autosomal recessive dyskeratosis congenita 3 (Disease Ontology:DOID:0070019); breast cancer (Disease Ontology:DOID:1612); rectal benign neoplasm (Disease Ontology:DOID:1984); motor neuron disease (Disease Ontology:DOID:231); ovarian cancer (Disease Ontology:DOID:2394); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); hepatocellular carcinoma (Disease Ontology:DOID:684); glottis squamous cell carcinoma (Disease Ontology:DOID:7031); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (dme:Dmel_CG9226)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;19285445;24149844", "class_list": "", "function": "RNA chaperone that plays a key role in Cajal body formation (PubMed:24149844). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) (PubMed:19285445). Probably acts by mediating localization of scaRNAs to Cajal bodies (PubMed:24149844)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q960H9;Q9VMH1", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0034512 box C/D sno(s)RNA binding;GO:0140517 protein-RNA adaptor activity", "go_cellular_component": "GO:0015030 Cajal body", "go_biological_process": "GO:0030576 Cajal body organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6NL34-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q70PP2-1", "uniprot_id": [ { "id": "SMG1_DROME", "url": "https://www.uniprot.org/uniprot/Q70PP2", "type": "external" } ], "mass": 361587.0, "length": 3218, "protein_name": "Serine/threonine-protein kinase Smg1", "gene_name": "nonC", "organism": "Fruit fly", "refseq_name": "no-on-and-no-off transient C, isoform B", "refseq_ac": [ { "id": "NP_001284967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284967", "type": "external" } ], "gene_names_uniprotkb": "nonC; CG32743; CG4549; CG4555; Dmel\\CG32743; Dmel_CG32743; SMG1; Smg1; Smg; anon-EST:Liang-1.24; anon-WO0170980.133; clone 1.24; dSmg1; rst(1a)cyr; smg1", "gene_names_refseq": "CG32743; CG4549; CG4555; Dmel\\CG32743; SMG1; Smg1; Smg; anon-EST:Liang-1.24; anon-WO0170980.133; clone 1.24; dSmg1; nonC; rst(1a)cyr; smg1", "protein_names_uniprotkb": "Serine/threonine-protein kinase Smg1; 2.7.11.1", "protein_names_refseq": "CG32743-PB; FRAP-related; Smg1; no on or off transient C; no-on-and-no-off transient C, isoform B; nonC-PB; resistance 1a cyromazine", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32743)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;12881430;15965240;16110336;16199763;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Serine/threonine protein kinase involved in mRNA surveillance. Recognizes the substrate consensus sequence [ST]-Q. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons, probably by phosphorylating Upf1., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NP14;Q9W3V6", "ec_number_list": [ { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "5.6.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.8", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0045202 synapse;GO:0038201 TOR complex", "go_biological_process": "GO:0007274 neuromuscular synaptic transmission;GO:0050808 synapse organization;GO:0006974 DNA damage response;GO:0046777 protein autophosphorylation;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q70PP2-1", "record_type": "protein", "filter_code": "0000000.0000101.001000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7JRE4-1", "uniprot_id": [ { "id": "MAN1_DROME", "url": "https://www.uniprot.org/uniprot/Q7JRE4", "type": "external" } ], "mass": 73879.0, "length": 650, "protein_name": "Inner nuclear membrane protein Man1", "gene_name": "MAN1", "organism": "Fruit fly", "refseq_name": "MAN1, isoform C", "refseq_ac": [ { "id": "NP_001286812", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286812", "type": "external" } ], "gene_names_uniprotkb": "MAN1; CG3167", "gene_names_refseq": "BcDNA:LD24895; CG3167; Dmel\\CG3167; MAN1; dMAN1; dMan1", "protein_names_uniprotkb": "Inner nuclear membrane protein Man1; LEM domain-containing protein Man1", "protein_names_refseq": "CG3167-PC; MAN1, isoform C; MAN1-PC", "tax_id": 7227, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); cataract 46 juvenile-onset (Disease Ontology:DOID:0110243); Buschke-Ollendorff syndrome (Disease Ontology:DOID:0111536); Emery-Dreifuss muscular dystrophy (Disease Ontology:DOID:11726)", "pathway": " (dme:Dmel_CG3167)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10731132;12537569;12537572;16439308;18723885;20036230;24700158", "class_list": "", "function": "Inner nuclear membrane protein (PubMed:16439308). Acts as a negative regulator of the BMP (Dpp) signaling cascade during crossvein development in pupal wings and possibly during synaptic transmission at the neuromuscular junction (NMJ) (PubMed:18723885, PubMed:20036230). Appears to be required for pupal development and consequently transition to the adult stage (PubMed:18723885, PubMed:20036230). During pupal development, plays essential and redundant functions with the other LEM domain proteins; bocks and Ote (PubMed:24700158)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q961B2", "ec_number_list": [], "go_molecular_function": "GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0012505 endomembrane system;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0030514 negative regulation of BMP signaling pathway;GO:0006998 nuclear envelope organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q7JRE4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7JWG9-1", "uniprot_id": [ { "id": "RM52_DROME", "url": "https://www.uniprot.org/uniprot/Q7JWG9", "type": "external" } ], "mass": 14187.0, "length": 126, "protein_name": "Large ribosomal subunit protein mL52", "gene_name": "mRpL52", "organism": "Fruit fly", "refseq_name": "mitochondrial ribosomal protein L52", "refseq_ac": [ { "id": "NP_610313", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610313", "type": "external" } ], "gene_names_uniprotkb": "mRpL52; CG1577", "gene_names_refseq": "BcDNA:RH01479; CG1577; Dmel\\CG1577; MRP-L52; mRpL52; rpl-52; rpl52", "protein_names_uniprotkb": "Large ribosomal subunit protein mL52; 39S ribosomal protein L52, mitochondrial; L52mt; MRP-L52", "protein_names_refseq": "CG1577-PA; mRpL52-PA; mitochondrial ribosomal protein L52", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1577); (R-DME-5389840); (R-DME-5419276); (R-DME-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1Z732", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7JWG9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7JXF5-1", "uniprot_id": [ { "id": "NUP62_DROME", "url": "https://www.uniprot.org/uniprot/Q7JXF5", "type": "external" } ], "mass": 40684.0, "length": 394, "protein_name": "Nuclear pore glycoprotein p62", "gene_name": "Nup62", "organism": "Fruit fly", "refseq_name": "nucleoporin 62kD, isoform B", "refseq_ac": [ { "id": "NP_001286489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286489", "type": "external" } ], "gene_names_uniprotkb": "Nup62; CG6251", "gene_names_refseq": "CG6251; Dmel\\CG6251; Nup62; nup62; p62", "protein_names_uniprotkb": "Nuclear pore glycoprotein p62; 62 kDa nucleoporin", "protein_names_refseq": "CG6251-PB; Nup62-PB; nucleoporin 62kD, isoform B; nucleoporin 62", "tax_id": 7227, "disease": "primary biliary cholangitis (Disease Ontology:DOID:12236); striatonigral degeneration (Disease Ontology:DOID:4751)", "pathway": " (dme:Dmel_CG6251); (R-DME-159227); (R-DME-159230); (R-DME-159231); (R-DME-159236); (R-DME-1855170); (R-DME-1855196); (R-DME-1855229); (R-DME-3108214); (R-DME-3301854); (R-DME-3371453); (R-DME-4085377); (R-DME-4551638); (R-DME-4615885)", "pathway_count": 14, "publication_count": 9, "publication_id_list": "10731132;12537569;12537572;20144760;26341556;28604694;33925313;40245499;7641726", "class_list": "", "function": "Essential component of the nuclear pore complex (By similarity). The N-terminal is probably involved in nucleocytoplasmic transport (By similarity). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of Nup62 to the pore complex (By similarity). Binds to transcriptionally active genes (PubMed:20144760). Negatively regulates chromatin attachment to the nuclear envelope, probably by preventing chromatin tethering by Nup154 (PubMed:26341556)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 20, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 20, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 20, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 21, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0031490 chromatin DNA binding;GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0000922 spindle pole;GO:0005635 nuclear envelope;GO:0005813 centrosome;GO:0000785 chromatin;GO:0044613 nuclear pore central transport channel", "go_biological_process": "GO:0006913 nucleocytoplasmic transport;GO:0097298 regulation of nucleus size;GO:0051028 mRNA transport;GO:0006405 RNA export from nucleus;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q7JXF5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7JXF7-1", "uniprot_id": [ { "id": "SEELE_DROME", "url": "https://www.uniprot.org/uniprot/Q7JXF7", "type": "external" } ], "mass": 21301.0, "length": 189, "protein_name": "Protein seele", "gene_name": "sel", "organism": "Fruit fly", "refseq_name": "seele", "refseq_ac": [ { "id": "NP_610547", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610547", "type": "external" } ], "gene_names_uniprotkb": "sel; CG12918", "gene_names_refseq": "CG12918; CNPYa; Dmel\\CG12918; Sle; sel", "protein_names_uniprotkb": "Protein seele", "protein_names_refseq": "CG12918-PA; seele; sel-PA", "tax_id": 7227, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (dme:Dmel_CG12918)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;20970335;40245499", "class_list": "", "function": "Involved in embryonic dorsal-ventral patterning which is generated by a series of serine protease processing events where gd processes snk which cleaves ea which then processes spz into the activating ligand for the Toll receptor. Required during this process for the secretion of ea from the developing embryo into the perivitelline space and for ea processing., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0012505 endomembrane system", "go_biological_process": "GO:0006457 protein folding;GO:0050708 regulation of protein secretion;GO:0070613 regulation of protein processing;GO:0007311 maternal specification of dorsal/ventral axis, oocyte, germ-line encoded;GO:0009951 polarity specification of dorsal/ventral axis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q7JXF7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7JYV2-1", "uniprot_id": [ { "id": "SNG_DROME", "url": "https://www.uniprot.org/uniprot/Q7JYV2", "type": "external" } ], "mass": 26610.0, "length": 241, "protein_name": "Synaptogyrin", "gene_name": "Syngr", "organism": "Fruit fly", "refseq_name": "synaptogyrin", "refseq_ac": [ { "id": "NP_610908", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610908", "type": "external" } ], "gene_names_uniprotkb": "Syngr; CG10808; gyr", "gene_names_refseq": "CG10808; Dmel\\CG10808; Gyr; Syngr; gyr; sng-1; synaptogyrin", "protein_names_uniprotkb": "Synaptogyrin", "protein_names_refseq": "CG10808-PA; Syngr-PA; synaptogyrin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10808); (R-DME-6798695)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537572;23238721", "class_list": "", "function": "Required for the correct formation of synaptic vesicles at nerve terminals and has a role in the regulation of the synaptic vesicle exo-endocytic cycle., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031594 neuromuscular junction;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0016079 synaptic vesicle exocytosis;GO:0048489 synaptic vesicle transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7JYV2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7JYX0-1", "uniprot_id": [ { "id": "GSTEE_DROME", "url": "https://www.uniprot.org/uniprot/Q7JYX0", "type": "external" } ], "mass": 26622.0, "length": 232, "protein_name": "Glutathione S-transferase E14", "gene_name": "GstE14", "organism": "Fruit fly", "refseq_name": "glutathione S transferase E14", "refseq_ac": [ { "id": "NP_610855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610855", "type": "external" } ], "gene_names_uniprotkb": "GstE14; CG4688; GSTD14-14; nobo", "gene_names_refseq": "CG4688; DmGSTE14; DmNobo; Dmel\\CG4688; GSTE14; GstE14; Nobo; gste14; nobo", "protein_names_uniprotkb": "Glutathione S-transferase E14; 2.5.1.18; Protein noppera-bo", "protein_names_refseq": "CG4688-PA; GstE14-PA; Noppera-bo; glutathione S transferase E14", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4688)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;22082028;25300303;25344753", "class_list": "", "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). Essential for ecdysteroid biosynthesis (PubMed:25300303, PubMed:25344753). May be involved in detoxification (PubMed:22082028)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.5.1.1", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0004769 steroid Delta-isomerase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0042632 cholesterol homeostasis;GO:0009636 response to toxic substance;GO:0006749 glutathione metabolic process;GO:0045456 ecdysteroid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7JYX0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7JZV0-1", "uniprot_id": [ { "id": "LCP2A_DROME", "url": "https://www.uniprot.org/uniprot/Q7JZV0", "type": "external" } ], "mass": 12680.0, "length": 117, "protein_name": "Cuticular protein 47Eg", "gene_name": "Cpr47Eg", "organism": "Fruit fly", "refseq_name": "cuticular protein 47Eg", "refseq_ac": [ { "id": "NP_610661", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610661", "type": "external" } ], "gene_names_uniprotkb": "Cpr47Eg; CG9070; Lcp2a", "gene_names_refseq": "BcDNA:RE09259; CG9070; Cpr47Eg; Cpr47eg; Dmel\\CG9070; LCPX2; Lcp2a", "protein_names_uniprotkb": "Cuticular protein 47Eg; Larval cuticle protein 2A", "protein_names_refseq": "CG9070-PA; Cpr47Eg-PA; Lcp2a; cuticular protein 47Eg; larval cuticle protein 2a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9070)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Component of the larval cuticle., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P82383", "ec_number_list": [], "go_molecular_function": "GO:0008010 structural constituent of chitin-based larval cuticle", "go_cellular_component": "GO:0062129 chitin-based extracellular matrix", "go_biological_process": "GO:0040003 chitin-based cuticle development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7JZV0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7K0P4-1", "uniprot_id": [ { "id": "PGAP3_DROME", "url": "https://www.uniprot.org/uniprot/Q7K0P4", "type": "external" } ], "mass": 38113.0, "length": 326, "protein_name": "Post-GPI attachment to proteins factor 3", "gene_name": "PGAP3", "organism": "Fruit fly", "refseq_name": "Post-GPI attachment to proteins 3, isoform B", "refseq_ac": [ { "id": "NP_610223", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610223", "type": "external" } ], "gene_names_uniprotkb": "PGAP3; CG3271", "gene_names_refseq": "CG3271; Dmel\\CG3271; PGAP3", "protein_names_uniprotkb": "Post-GPI attachment to proteins factor 3", "protein_names_refseq": "CG3271-PB; PGAP3-PB; Post-GPI attachment to proteins 3 ortholog; Post-GPI attachment to proteins 3, isoform B", "tax_id": 7227, "disease": "hyperphosphatasia with impaired intellectual development syndrome (Disease Ontology:DOID:0070431); hyperphosphatasia with impaired intellectual development syndrome 4 (Disease Ontology:DOID:0070436); chronic asthma (Disease Ontology:DOID:0080809); allergic asthma (Disease Ontology:DOID:9415)", "pathway": " (dme:Dmel_CG3271)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;17893096", "class_list": "", "function": "Involved in the lipid remodeling steps of GPI-anchor maturation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A1Z6N0", "ec_number_list": [], "go_molecular_function": "GO:0016788 hydrolase activity, acting on ester bonds", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0006505 GPI anchor metabolic process;GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7K0P4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7K1Z5-1", "uniprot_id": [ { "id": "UFC1_DROME", "url": "https://www.uniprot.org/uniprot/Q7K1Z5", "type": "external" } ], "mass": 19004.0, "length": 164, "protein_name": "Ubiquitin-fold modifier-conjugating enzyme 1", "gene_name": "Ufc1", "organism": "Fruit fly", "refseq_name": "Ubiquitin-fold modifier conjugating enzyme 1", "refseq_ac": [ { "id": "NP_611074", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611074", "type": "external" } ], "gene_names_uniprotkb": "Ufc1; CG8386", "gene_names_refseq": "CG8386; Dmel\\CG8386; Ufc1; dUFC1", "protein_names_uniprotkb": "Ubiquitin-fold modifier-conjugating enzyme 1; Ufm1-conjugating enzyme 1", "protein_names_refseq": "CG8386-PA; Ubiquitin-fold modifier conjugating enzyme 1; Ufc1-PA", "tax_id": 7227, "disease": "neurodevelopmental disorder with spasticity and poor growth (Disease Ontology:DOID:0070421)", "pathway": " (dme:Dmel_CG8386)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;26872069;37086384", "class_list": "", "function": "E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage (By similarity). As part of Ufm1 cascade, might play a role in the development of the neuromuscular junctions (PubMed:26872069)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1B2AJX6", "ec_number_list": [], "go_molecular_function": "GO:0071568 UFM1 transferase activity;GO:0061657 UFM1 conjugating enzyme activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0034976 response to endoplasmic reticulum stress;GO:0071569 protein ufmylation;GO:0061709 reticulophagy", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7K1Z5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7K2B0-1", "uniprot_id": [ { "id": "RRP8_DROME", "url": "https://www.uniprot.org/uniprot/Q7K2B0", "type": "external" } ], "mass": 40288.0, "length": 358, "protein_name": "Ribosomal RNA-processing protein 8", "gene_name": "CG7137", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_611400", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611400", "type": "external" } ], "gene_names_uniprotkb": "CG7137", "gene_names_refseq": "CG7137; Dmel\\CG7137", "protein_names_uniprotkb": "Ribosomal RNA-processing protein 8; 2.1.1.-", "protein_names_refseq": "CG7137-PA; gene 3; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7137); (R-DME-427359)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18327897", "class_list": "", "function": "Probable methyltransferase required to silence rDNA., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" } ], "go_molecular_function": "GO:0016433 rRNA (adenine) methyltransferase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005677 chromatin silencing complex;GO:0033553 rDNA heterochromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0042149 cellular response to glucose starvation;GO:0000183 rDNA heterochromatin formation;GO:0046015 regulation of transcription by glucose", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7K2B0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7K2X8-1", "uniprot_id": [ { "id": "SEH1_DROME", "url": "https://www.uniprot.org/uniprot/Q7K2X8", "type": "external" } ], "mass": 39515.0, "length": 354, "protein_name": "Nucleoporin seh1", "gene_name": "Nup44A", "organism": "Fruit fly", "refseq_name": "nucleoporin at 44A, isoform A", "refseq_ac": [ { "id": "NP_610343", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610343", "type": "external" } ], "gene_names_uniprotkb": "Nup44A; CG8722; seh1", "gene_names_refseq": "CG8722; Dmel\\CG8722; FBgn 33247; GATOR2; Nup44A/Seh1; Nup44A; SEH1; Seh1; nup44A; seh1", "protein_names_uniprotkb": "Nucleoporin seh1; GATOR complex protein seh1; Nucleoporin complex protein 44A", "protein_names_refseq": "CG8722-PA; Nup44A-PA; nucleoporin 44A; nucleoporin at 44A, isoform A; nucleoporin-44A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8722); (R-DME-159227); (R-DME-159230); (R-DME-159231); (R-DME-159236); (R-DME-1855170); (R-DME-1855196); (R-DME-1855229); (R-DME-3108214); (R-DME-3301854); (R-DME-3371453); (R-DME-4085377); (R-DME-4551638); (R-DME-4615885); (R-DME-9615933)", "pathway_count": 15, "publication_count": 9, "publication_id_list": "10731132;12537569;12537572;21521741;23723238;25512509;27166823;38514639;40245499", "class_list": "", "function": "An essential component of the GATOR subcomplex GATOR2 which functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:27166823). The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the mTORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation (PubMed:23723238, PubMed:25512509, PubMed:27166823). GATOR2 activates the mTORC1 signaling pathway through the inhibition of the GATOR1 subcomplex, controlling the switch to cell proliferation growth under nutrient replete conditions and growth during female oocyte development (PubMed:21521741, PubMed:23723238, PubMed:25512509, PubMed:27166823). This component is required for activating mTORC1 specifically in germline cells to promote cell growth and maintain the oocyte fate, probably influences the organization and/or function of microtubules within ovarian cysts, and promotes accumulation of another GATOR2 complex member mio in germline and somatic tissues (PubMed:21521741, PubMed:23723238, PubMed:25512509, PubMed:27166823). GATOR1 and GATOR2 act at different stages of oogenesis to regulate mTORC1 in order to control meiotic entry and promote oocyte growth and development (PubMed:25512509). After exactly four mitotic cyst divisions, the GATOR1 complex members (Iml1, Nprl2 and Nprl3) down-regulate mTORC1 to slow cellular metabolism and promote the mitotic/meiotic transition (PubMed:25512509). At later stages of oogenesis, the mio and Nup44A components of the GATOR2 complex inhibit GATOR1 and thus activate mTORC1 to promote meiotic progression, and drive oocyte growth and development (PubMed:21521741, PubMed:25512509). In addition to its role in the regulation of the mTORC1 complex, functions independently of mTORC1 to prevent the inappropriate accumulation of autolysosomes in germline tissues (PubMed:27166823)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Probable component of the nuclear pore complex (NPC) (By similarity). Involved in maintaining the localization of another nucleoporin Mgtor to the nuclear envelope of early meiotic female germline cells (PubMed:21521741). It is not involved in recruiting the nucleoporins Mgtor, Nup107, Nup153 and FG-containing nucleoporins to the NPC (PubMed:21521741)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0031080 nuclear pore outer ring;GO:0005635 nuclear envelope;GO:0005764 lysosome;GO:0032991 protein-containing complex;GO:0044754 autolysosome", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0006913 nucleocytoplasmic transport;GO:0015031 protein transport;GO:0051301 cell division;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q7K2X8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7K4M4-1", "uniprot_id": [ { "id": "TEF_DROME", "url": "https://www.uniprot.org/uniprot/Q7K4M4", "type": "external" } ], "mass": 73358.0, "length": 649, "protein_name": "Protein teflon", "gene_name": "tef", "organism": "Fruit fly", "refseq_name": "teflon", "refseq_ac": [ { "id": "NP_523766", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523766", "type": "external" } ], "gene_names_uniprotkb": "tef; CG8961", "gene_names_refseq": "CG8961; Dmel\\CG8961; l(2)k15914; tef", "protein_names_uniprotkb": "Protein teflon", "protein_names_refseq": "CG8961-PA; lethal (2) k15914; tef-PA; teflon", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8961)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;11139508;12537569;12537572;16816414;18984573", "class_list": "", "function": "Specifically required in males for proper segregation of autosomal bivalents at meiosis I. Expression is required in the male germ line prior to spermatocyte stage S4. May have a role as a bridging molecule maintaining adhesion to hold autosome bivalents together via heterochromatic connections., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B6UYC2;B6UYC7;B6UYC8;B6UYD0;B6UYD1;B6UYD2;B6UYD3;B6UYD5;B6UYD6;B6UYD8;B6UYE0;B6UYE5;B6UYE6;B6UYE9;B6UYF1;B6UYF2;B6UYF3;Q5MBE0", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0030849 autosome", "go_biological_process": "GO:0007060 male meiosis chromosome segregation;GO:0007141 male meiosis I;GO:0051308 male meiosis chromosome separation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7K4M4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7K5M0-1", "uniprot_id": [ { "id": "SCARF_DROME", "url": "https://www.uniprot.org/uniprot/Q7K5M0", "type": "external" } ], "mass": 71417.0, "length": 655, "protein_name": "Inactive serine protease scarface", "gene_name": "scaf", "organism": "Fruit fly", "refseq_name": "scarface, isoform B", "refseq_ac": [ { "id": "NP_610180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610180", "type": "external" } ], "gene_names_uniprotkb": "scaf; CG11066; scarf", "gene_names_refseq": "CG11066; CG15900; Dmel\\CG11066; SPH142; Scaf; cSPH142; scaf; scarf", "protein_names_uniprotkb": "Inactive serine protease scarface", "protein_names_refseq": "CG11066-PB; scaf-PB; scarface, isoform B; scarface", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11066)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10731132;12537569;12537572;15342518;20379222;20530545;25737837;28628612;40245499", "class_list": "", "function": "Inactive serine protease that plays a role in germ-band retraction and dorsal closure morphogenesis in embryogenesis; contributes to amnioserosa attachment and epithelial apico-basal polarity by regulating the localization of laminin LanA on the apical side of the amnioserosa epithelium (PubMed:20379222, PubMed:28628612). Contributes to epithelial morphogenesis probably by regulating the bsk/JNK pathway, as part of a negative-feedback loop, and by modulating the cross-talk between the Egfr, bsk/JNK and dpp signal transduction pathways (PubMed:20379222, PubMed:28628612). In larval development, antagonizes the morphogenetic movements controlled by the bsk/JNK signaling including male genitalia formation and thorax development (PubMed:20379222, PubMed:20530545, PubMed:25737837)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0050793 regulation of developmental process;GO:0006508 proteolysis;GO:0045087 innate immune response;GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity;GO:0048803 imaginal disc-derived male genitalia morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q7K5M0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KJ69-1", "uniprot_id": [ { "id": "Q7KJ69_DROME", "url": "https://www.uniprot.org/uniprot/Q7KJ69", "type": "external" } ], "mass": 18409.0, "length": 161, "protein_name": "SKP1-related B", "gene_name": "SkpB", "organism": "Fruit fly", "refseq_name": "SKP1-related B", "refseq_ac": [ { "id": "NP_610729", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610729", "type": "external" } ], "gene_names_uniprotkb": "SkpB; CG8881; Dmel\\CG8881; Dmel_CG8881; Skp; dskpB; skpB", "gene_names_refseq": "CG8881; Dmel\\CG8881; SkpB; Skp; dskpB; skpB", "protein_names_uniprotkb": "SKP1-related B", "protein_names_refseq": "CG8881-PA; SKP1-related B; SkpB-PA; skpB", "tax_id": 7227, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (dme:Dmel_CG8881)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0097602 cullin family protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q7KJ69-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KKH3-1", "uniprot_id": [ { "id": "SDA1_DROME", "url": "https://www.uniprot.org/uniprot/Q7KKH3", "type": "external" } ], "mass": 81984.0, "length": 712, "protein_name": "Protein SDA1 homolog", "gene_name": "Mys45A", "organism": "Fruit fly", "refseq_name": "mystery 45A", "refseq_ac": [ { "id": "NP_610455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610455", "type": "external" } ], "gene_names_uniprotkb": "Mys45A; CG8070", "gene_names_refseq": "CG8070; Dmel\\CG8070; Mys-45A; Mys45A; Mys45a; anon-WO0118547.170", "protein_names_uniprotkb": "Protein SDA1 homolog; Mystery protein 45A", "protein_names_refseq": "CG8070-PA; Mys45A-PA; mystery 45A; mystery", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8070)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;11691839;12537569;12537572;18327897", "class_list": "", "function": "Required for 60S pre-ribosomal subunits export to the cytoplasm., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0000055 ribosomal large subunit export from nucleus;GO:0015031 protein transport;GO:0042273 ribosomal large subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7KKH3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KM15-1", "uniprot_id": [ { "id": "Q7KM15_DROME", "url": "https://www.uniprot.org/uniprot/Q7KM15", "type": "external" } ], "mass": 17738.0, "length": 169, "protein_name": "Transcription factor BTF3", "gene_name": "bic", "organism": "Fruit fly", "refseq_name": "bicaudal, isoform A", "refseq_ac": [ { "id": "NP_476853", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476853", "type": "external" } ], "gene_names_uniprotkb": "bic; 12; 5A; BTF3; BcDNA.GM05329; BcDNA:GM05329; Bic; Btf; CG3644; Dmel\\CG3644; Dmel_CG3644; E(2)Bic; E(Bic); NAC-beta; l(2)49Da; l(2)k10712; l(2)vr22; vr22", "gene_names_refseq": "107/12; 5A; BTF3; BcDNA.GM05329; BcDNA:GM05329; Bic; Btf; CG3644; Dmel\\CG3644; E(2)Bic; E(Bic); NAC-beta; bic; l(2)49Da; l(2)k10712; l(2)vr22; vr22", "protein_names_uniprotkb": "Transcription factor BTF3", "protein_names_refseq": "CG3644-PA; bic-PA; bicaudal, isoform A; enhancer of bicaudal", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3644)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005854 nascent polypeptide-associated complex", "go_biological_process": "GO:0070201 regulation of establishment of protein localization;GO:0007317 regulation of pole plasm oskar mRNA localization;GO:0060811 intracellular mRNA localization involved in anterior/posterior axis specification", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q7KM15-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KMJ6-1", "uniprot_id": [ { "id": "NITO_DROME", "url": "https://www.uniprot.org/uniprot/Q7KMJ6", "type": "external" } ], "mass": 89053.0, "length": 793, "protein_name": "RNA-binding protein spenito", "gene_name": "nito", "organism": "Fruit fly", "refseq_name": "spenito, isoform C", "refseq_ac": [ { "id": "NP_001286174", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286174", "type": "external" } ], "gene_names_uniprotkb": "nito; CG2910", "gene_names_refseq": "BcDNA:GH11110; CG2910; Dm44A/spenito; DmSSp; Dmel\\CG2910; Nito; SSLP; Spenito; cg2910; dOTT; nito", "protein_names_uniprotkb": "RNA-binding protein spenito", "protein_names_refseq": "CG2910-PC; One twenty Two; Spen-like protein; nito-PC; spenito, isoform C; spenito", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2910)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537569;12537572;16547102;18174108;25040100;26324914;27919077;28675155;29535189;29555755", "class_list": "", "function": "RNA-binding protein that acts as an associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs (PubMed:27919077, PubMed:29535189, PubMed:29555755). M6a modification plays a role in the efficiency of mRNA splicing and is required for sex determination (PubMed:27919077, PubMed:29535189, PubMed:29555755). In the WMM complex, may act by binding target RNAs and recruiting the WMM complex (PubMed:29535189). Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy (PubMed:26324914, PubMed:29535189, PubMed:29555755). M6A methylation is also required for neuronal functions (PubMed:27919077). Acts as a positive regulator of canonical Wg signaling during wing disk and eye development (PubMed:16547102, PubMed:18174108)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8T0B2", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0036396 RNA N6-methyladenosine methyltransferase complex;GO:0005634 nucleus;GO:0071011 precatalytic spliceosome", "go_biological_process": "GO:0048749 compound eye development;GO:0010628 positive regulation of gene expression;GO:0030154 cell differentiation;GO:0007548 sex differentiation;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q7KMJ6-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KN90-1", "uniprot_id": [ { "id": "SYCC_DROME", "url": "https://www.uniprot.org/uniprot/Q7KN90", "type": "external" } ], "mass": 84258.0, "length": 741, "protein_name": "Cysteine--tRNA ligase, cytoplasmic", "gene_name": "CysRS", "organism": "Fruit fly", "refseq_name": "Cysteinyl-tRNA synthetase", "refseq_ac": [ { "id": "NP_611087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611087", "type": "external" } ], "gene_names_uniprotkb": "CysRS; Aats-cys; CG8431", "gene_names_refseq": "Aats-cys; BcDNA:LD21177; CARS; CG8431; CRS; CysRS; Dmel\\CG8431; dCARS", "protein_names_uniprotkb": "Cysteine--tRNA ligase, cytoplasmic; 6.1.1.16; Cysteinyl-tRNA synthetase", "protein_names_refseq": "CG8431-PA; CysRS-PA; Cysteinyl-tRNA synthetase", "tax_id": 7227, "disease": "microcephaly (Disease Ontology:DOID:10907)", "pathway": " (dme:Dmel_CG8431)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;10731138;12537572;17372656", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.16", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0000049 tRNA binding;GO:0004817 cysteine-tRNA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006423 cysteinyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7KN90-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KR04-1", "uniprot_id": [ { "id": "RS15B_DROME", "url": "https://www.uniprot.org/uniprot/Q7KR04", "type": "external" } ], "mass": 14741.0, "length": 130, "protein_name": "Small ribosomal subunit protein uS8B", "gene_name": "RpS15Ab", "organism": "Fruit fly", "refseq_name": "ribosomal protein S15Ab", "refseq_ac": [ { "id": "NP_610616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610616", "type": "external" } ], "gene_names_uniprotkb": "RpS15Ab; CG12324; RpS15A", "gene_names_refseq": "CG12324; CT22283; Dmel\\CG12324; RPS15Ab; RpS15Ab; RpS15A", "protein_names_uniprotkb": "Small ribosomal subunit protein uS8B; 40S ribosomal protein S15Ab", "protein_names_refseq": "CG12324-PA; RpS15Ab-PA; ribosomal protein S15Ab", "tax_id": 7227, "disease": "Diamond-Blackfan anemia 20 (Disease Ontology:DOID:0111891)", "pathway": " (dme:Dmel_CG12324)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12466289;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8I8H7", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7KR04-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KRW8-1", "uniprot_id": [ { "id": "PRP39_DROME", "url": "https://www.uniprot.org/uniprot/Q7KRW8", "type": "external" } ], "mass": 120546.0, "length": 1066, "protein_name": "Pre-mRNA-processing factor 39", "gene_name": "Prp39", "organism": "Fruit fly", "refseq_name": "pre-mRNA processing factor 39, isoform E", "refseq_ac": [ { "id": "NP_001097957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097957", "type": "external" } ], "gene_names_uniprotkb": "Prp39; CG1646", "gene_names_refseq": "CG1646; Dmel\\CG1646; Prp39", "protein_names_uniprotkb": "Pre-mRNA-processing factor 39; PRP39 homolog", "protein_names_refseq": "CG1646-PE; Prp39-PE; pre-mRNA processing factor 39, isoform E", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1646)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;17372656;18327897", "class_list": "", "function": "Involved in pre-mRNA splicing., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8JRF2;A8JRF3;A8JRF4;Q86B75;Q9VAT3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0000243 commitment complex;GO:0071004 U2-type prespliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0000381 regulation of alternative mRNA splicing, via spliceosome;GO:0000395 mRNA 5'-splice site recognition", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7KRW8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KUD5-1", "uniprot_id": [ { "id": "INSL5_DROME", "url": "https://www.uniprot.org/uniprot/Q7KUD5", "type": "external" } ], "mass": 11972.0, "length": 108, "protein_name": "Insulin-like peptide 5", "gene_name": "Ilp5", "organism": "Fruit fly", "refseq_name": "Insulin-like peptide 5", "refseq_ac": [ { "id": "NP_996037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996037", "type": "external" } ], "gene_names_uniprotkb": "Ilp5; CG33273; HDC09365", "gene_names_refseq": "CG33273; DILP 5; DILP-5; DILP5; DILPs; DILP; Dilp 5; Dilp-5; Dilp1-5; Dilp5; Dilp; Dmel\\CG33273; ILP5; ILPs; Ilp-5; Ilp5; Ilp; dILP-5; dILP5; dIlp5; dilp-5; dilp5; dilp; dipl5; dlp; ilp5", "protein_names_uniprotkb": "Insulin-like peptide 5; Insulin-related peptide 5; dILP5", "protein_names_refseq": "CG33273-PB; Ilp5-PB; Insulin-like peptide 5; Insulin-like peptide; drosophila insulin-like peptide 5; insulin like peptide 5; insulin-like peptide-5; insulin/insulin-like growth factor", "tax_id": 7227, "disease": "sleep disorder (Disease Ontology:DOID:535)", "pathway": " (dme:Dmel_CG33273); (R-DME-110478)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10455177;10731132;10801879;11250149;11752451;11872800;12537572;12893776;14709175;37805602;7628438;8978685;9169420;9368760", "class_list": "", "function": "Ligand of InR/insulin-like receptor., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ILJ3", "ec_number_list": [], "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0005179 hormone activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0060180 female mating behavior;GO:0033500 carbohydrate homeostasis;GO:0007626 locomotory behavior;GO:0030431 sleep;GO:0008286 insulin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q7KUD5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KV13-1", "uniprot_id": [ { "id": "STEL2_DROME", "url": "https://www.uniprot.org/uniprot/Q7KV13", "type": "external" } ], "mass": 19525.0, "length": 172, "protein_name": "Stellate protein CG33237", "gene_name": "Ste:CG33237", "organism": "Fruit fly", "refseq_name": "Ste:CG33237", "refseq_ac": [ { "id": "NP_996431", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996431", "type": "external" } ], "gene_names_uniprotkb": "Ste:CG33237; CG33237", "gene_names_refseq": "CG32605; CG33237; Dmel\\CG33237; Ste:CG33237", "protein_names_uniprotkb": "Stellate protein CG33237", "protein_names_refseq": "CG33237-PB; Ste:CG33237-PB; Ste:CG33237", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33237)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;11470406;11513298;12537572;7597082", "class_list": "", "function": "Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019887 protein kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005956 protein kinase CK2 complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7KV13-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KV14-1", "uniprot_id": [ { "id": "STEL3_DROME", "url": "https://www.uniprot.org/uniprot/Q7KV14", "type": "external" } ], "mass": 19600.0, "length": 172, "protein_name": "Stellate protein CG33238", "gene_name": "Ste:CG33238", "organism": "Fruit fly", "refseq_name": "Ste:CG33238", "refseq_ac": [ { "id": "NP_996430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996430", "type": "external" } ], "gene_names_uniprotkb": "Ste:CG33238; CG33238", "gene_names_refseq": "CG32605; CG33238; Dmel\\CG33238; Ste:CG33238", "protein_names_uniprotkb": "Stellate protein CG33238", "protein_names_refseq": "CG33238-PB; Ste:CG33238-PB; Ste:CG33238", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33238)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;11470406;11513298;12537572;7597082", "class_list": "", "function": "Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019887 protein kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005956 protein kinase CK2 complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7KV14-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KV15-1", "uniprot_id": [ { "id": "STEL4_DROME", "url": "https://www.uniprot.org/uniprot/Q7KV15", "type": "external" } ], "mass": 19543.0, "length": 172, "protein_name": "Stellate protein CG33239/CG33241", "gene_name": "Ste:CG33239; Ste:CG33241", "organism": "Fruit fly", "refseq_name": "Ste:CG33241", "refseq_ac": [ { "id": "NP_996427", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996427", "type": "external" } ], "gene_names_uniprotkb": "Ste:CG33239; Ste:CG33241; CG33239; CG33241", "gene_names_refseq": "CG32605; CG33241; Dmel\\CG33241; Ste:CG33241", "protein_names_uniprotkb": "Stellate protein CG33239/CG33241", "protein_names_refseq": "CG33241-PB; Ste:CG33241-PB; Ste:CG33241", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33239); (dme:Dmel_CG33241)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;11470406;11513298;12537572;7597082", "class_list": "", "function": "Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7KV17", "ec_number_list": [], "go_molecular_function": "GO:0019887 protein kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005956 protein kinase CK2 complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7KV15-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KV19-1", "uniprot_id": [ { "id": "STEL5_DROME", "url": "https://www.uniprot.org/uniprot/Q7KV19", "type": "external" } ], "mass": 19573.0, "length": 172, "protein_name": "Stellate protein CG33243", "gene_name": "Ste:CG33243", "organism": "Fruit fly", "refseq_name": "Ste:CG33243", "refseq_ac": [ { "id": "NP_996425", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996425", "type": "external" } ], "gene_names_uniprotkb": "Ste:CG33243; CG33243", "gene_names_refseq": "CG32605; CG33243; Dmel\\CG33243; Ste:CG33243", "protein_names_uniprotkb": "Stellate protein CG33243", "protein_names_refseq": "CG33243-PB; Ste:CG33243-PB; Ste:CG33243", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33243)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;11470406;11513298;12537572;7597082", "class_list": "", "function": "Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019887 protein kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005956 protein kinase CK2 complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7KV19-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KV22-1", "uniprot_id": [ { "id": "STEL6_DROME", "url": "https://www.uniprot.org/uniprot/Q7KV22", "type": "external" } ], "mass": 19479.0, "length": 172, "protein_name": "Stellate protein CG33246", "gene_name": "Ste:CG33246", "organism": "Fruit fly", "refseq_name": "Ste:CG33246", "refseq_ac": [ { "id": "NP_996422", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996422", "type": "external" } ], "gene_names_uniprotkb": "Ste:CG33246; CG33246", "gene_names_refseq": "CG32605; CG33246; Dmel\\CG33246; Ste:CG33246", "protein_names_uniprotkb": "Stellate protein CG33246", "protein_names_refseq": "CG33246-PB; Ste:CG33246-PB; Ste:CG33246", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33246)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;11470406;11513298;12537572;7597082", "class_list": "", "function": "Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019887 protein kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005956 protein kinase CK2 complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7KV22-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KV23-1", "uniprot_id": [ { "id": "STEL7_DROME", "url": "https://www.uniprot.org/uniprot/Q7KV23", "type": "external" } ], "mass": 19509.0, "length": 172, "protein_name": "Stellate protein CG33247", "gene_name": "Ste:CG33247", "organism": "Fruit fly", "refseq_name": "Ste:CG33247", "refseq_ac": [ { "id": "NP_996421", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996421", "type": "external" } ], "gene_names_uniprotkb": "Ste:CG33247; CG33247", "gene_names_refseq": "CG32605; CG33247; Dmel\\CG33247; Ste:CG33247", "protein_names_uniprotkb": "Stellate protein CG33247", "protein_names_refseq": "CG33247-PB; Ste:CG33247-PB; Ste:CG33247", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33247)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;11470406;11513298;12537572;7597082", "class_list": "", "function": "Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019887 protein kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005956 protein kinase CK2 complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7KV23-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7PLK0-1", "uniprot_id": [ { "id": "AGO3_DROME", "url": "https://www.uniprot.org/uniprot/Q7PLK0", "type": "external" } ], "mass": 99129.0, "length": 867, "protein_name": "Protein argonaute-3", "gene_name": "AGO3", "organism": "Fruit fly", "refseq_name": "argonaute 3, isoform D", "refseq_ac": [ { "id": "NP_001036627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036627", "type": "external" } ], "gene_names_uniprotkb": "AGO3; CG40300", "gene_names_refseq": "AGO-3; AGO3; Ago-3; Ago3; BEST:LD15785; CG40300; Dmel\\CG40300; ago3; dAgo3", "protein_names_uniprotkb": "Protein argonaute-3; 3.1.26.-", "protein_names_refseq": "AGO3-PD; Argonaute-3; Argonaute3; BEST:LD15785; CG40300-PD; argonaute 3, isoform D", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG40300)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;12537572;17322028;17346786;18201385;19377467;19395009;19959991;20953170;20980675;21447556;22303351;23559253;26212455;26295961;34210982", "class_list": "", "function": "Component of the perinuclear meiotic nuage, a germline-specific subcellular membraneless ribonucleoprotein compartment involved in production of transposable element-repressing Piwi-interacting RNA (piRNA)-induced silencing complexes (piRISCs), which are essential for maintaining germline integrity during oogenesis (PubMed:22303351, PubMed:26295961). Acts via the Piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:17322028, PubMed:17346786, PubMed:19395009, PubMed:20980675). Piwi protein that directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (PubMed:17322028, PubMed:17346786, PubMed:26212455, PubMed:26295961). Associates predominantly with sense piRNAs that contain adenine at nucleotide 10, but shows no preference for uridine at the 5' end (PubMed:17322028, PubMed:17346786, PubMed:26212455). Shows RNA cleavage or slicer activity (PubMed:17322028). Together with Piwi protein aub recruited to subregions of the perinuclear nuage by krimp, which coordinates their activity in the ping-pong amplification step of secondary piRNA biogenesis (PubMed:26295961, PubMed:34210982). Krimp recruits piRNA bound aub and unbound AGO3, bringing them into close proximity to facilitate the loading onto AGO3 of freshly cut piRNAs generated by aub cleavage of target sequences; krimp recognizes the piRNA loading state of the Piwi proteins via symmetrically dimethylated arginine modification in their N-terminus (PubMed:34210982). Important for asymmetric ping-pong amplification to bias production towards antisense piRNAs capable of silencing transposable elements (PubMed:19395009, PubMed:26212455). In testis, associates with Su(Ste) and AT-chX-1 piRNAs mostly produced from antisense precursors (PubMed:20980675). In the germline, acts to amplify pools of antisense piRNAs, among others Su(Ste), AT-chX-1 and roo, and to limit sense piRNA accumulation (PubMed:20980675). Forms a complex with smg, twin, aub and specific piRNAs that targets nos mRNA (and probably other maternal mRNAS) for deadenylation promoting its decay during early embryogenesis (PubMed:20953170). Involved in transposon silencing in the adult brain (PubMed:23559253)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4GND8;A4GUJ7;A7YFW6;B6IDV1;B7FNN2;K7WKR9;K7XHY4", "ec_number_list": [], "go_molecular_function": "GO:0004521 RNA endonuclease activity;GO:0034584 piRNA binding;GO:0016891 RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism", "go_cellular_component": "GO:0031315 extrinsic component of mitochondrial outer membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0031047 regulatory ncRNA-mediated gene silencing;GO:0048477 oogenesis;GO:0034587 piRNA processing;GO:0140965 secondary piRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q7PLK0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7YTY6-1", "uniprot_id": [ { "id": "SP42D_DROME", "url": "https://www.uniprot.org/uniprot/Q7YTY6", "type": "external" } ], "mass": 41179.0, "length": 372, "protein_name": "Serine protease inhibitor 42Dd", "gene_name": "Spn42Dd", "organism": "Fruit fly", "refseq_name": "serpin 42Dd", "refseq_ac": [ { "id": "NP_001163067", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163067", "type": "external" } ], "gene_names_uniprotkb": "Spn42Dd; CG9456; Spn1", "gene_names_refseq": "CG9456; Dmel\\CG9456; Spn1; Spn42Dd; sp1", "protein_names_uniprotkb": "Serine protease inhibitor 42Dd; Serpin 42Dd", "protein_names_refseq": "CG9456-PB; Spn42Dd-PB; serine protease inhibitor 1; serpin 1; serpin 42Dd", "tax_id": 7227, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); coarctation of the aorta (Disease Ontology:DOID:0051054); stroke (Disease Ontology:DOID:0051061); chemical colitis (Disease Ontology:DOID:0060186); ileitis (Disease Ontology:DOID:0060189); atrial fibrillation (Disease Ontology:DOID:0060224); thrombosis (Disease Ontology:DOID:0060903); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); Nagashima-type palmoplantar keratosis (Disease Ontology:DOID:0070555); polycystic kidney disease (Disease Ontology:DOID:0080322); corticosteroid-binding globulin deficiency (Disease Ontology:DOID:0090030); osteonecrosis (Disease Ontology:DOID:10159); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); nephritis (Disease Ontology:DOID:10952); meconium aspiration syndrome (Disease Ontology:DOID:11049); hydronephrosis (Disease Ontology:DOID:11111); IgA vasculitis (Disease Ontology:DOID:11123); disseminated intravascular coagulation (Disease Ontology:DOID:11247); adult respiratory distress syndrome (Disease Ontology:DOID:11394); pulmonary edema (Disease Ontology:DOID:11396); sciatic neuropathy (Disease Ontology:DOID:11446); prediabetes syndrome (Disease Ontology:DOID:11716); nephrotic syndrome (Disease Ontology:DOID:1184); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); allergic disease (Disease Ontology:DOID:1205); otosclerosis (Disease Ontology:DOID:12185); primary biliary cholangitis (Disease Ontology:DOID:12236); alcoholic hepatitis (Disease Ontology:DOID:12351); dilated cardiomyopathy (Disease Ontology:DOID:12930); retinopathy of prematurity (Disease Ontology:DOID:13025); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); uveitis (Disease Ontology:DOID:13141); alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372); sick sinus syndrome (Disease Ontology:DOID:13884); toxic shock syndrome (Disease Ontology:DOID:14115); Fabry disease (Disease Ontology:DOID:14499); cystic fibrosis (Disease Ontology:DOID:1485); diffuse scleroderma (Disease Ontology:DOID:1580); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); impotence (Disease Ontology:DOID:1875); atherosclerosis (Disease Ontology:DOID:1936); hyperinsulinism (Disease Ontology:DOID:2018); transient cerebral ischemia (Disease Ontology:DOID:224); arteriosclerosis (Disease Ontology:DOID:2349); multiple sclerosis (Disease Ontology:DOID:2377); central retinal vein occlusion (Disease Ontology:DOID:2450); endometriosis (Disease Ontology:DOID:289); acute pancreatitis (Disease Ontology:DOID:2913); glomerulonephritis (Disease Ontology:DOID:2921); severe acute respiratory syndrome (Disease Ontology:DOID:2945); IgA glomerulonephritis (Disease Ontology:DOID:2986); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); temporal lobe epilepsy (Disease Ontology:DOID:3328); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); antithrombin III deficiency (Disease Ontology:DOID:3755); pulmonary fibrosis (Disease Ontology:DOID:3770); lung adenocarcinoma (Disease Ontology:DOID:3910); liver disease (Disease Ontology:DOID:409); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); cerebrovascular disease (Disease Ontology:DOID:6713); osteoarthritis (Disease Ontology:DOID:8398); chronic myeloid leukemia (Disease Ontology:DOID:8552); vasculitis (Disease Ontology:DOID:865); intermediate coronary syndrome (Disease Ontology:DOID:8805); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675); mitral valve prolapse (Disease Ontology:DOID:988); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG9456); (R-DME-114608); (R-DME-194002); (R-DME-2022377); (R-DME-204005); (R-DME-381426); (R-DME-5694530); (R-DME-6798695); (R-DME-8957275); (R-DME-9757110); (R-DME-9769739)", "pathway_count": 11, "publication_count": 4, "publication_id_list": "10692585;10731132;12537572;21576362", "class_list": "", "function": "Serine protease inhibitor with activity toward trypsin. Involved in innate immunity to fungal infection by negatively regulating the Toll signaling pathway and suppressing the expression of the antifungal peptide drosomycin. Acts upstream of SPE and grass, and downstream of the fungal cell wall pattern recognition receptor GNBP3. May function specifically in the GNBP3-dependent beta-1,3-glucan branch of the Toll pathway., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 89, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q7KA42", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:1905035 negative regulation of antifungal innate immune response;GO:0007320 insemination;GO:0045861 negative regulation of proteolysis;GO:0002376 immune system process;GO:0002785 negative regulation of antimicrobial peptide production", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7YTY6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7Z2C4-1", "uniprot_id": [ { "id": "SELG_DROME", "url": "https://www.uniprot.org/uniprot/Q7Z2C4", "type": "external" } ], "mass": 11574.0, "length": 110, "protein_name": "Glycine-rich selenoprotein", "gene_name": "SelG", "organism": "Fruit fly", "refseq_name": "selenoprotein G", "refseq_ac": [ { "id": "NP_572763", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572763", "type": "external" } ], "gene_names_uniprotkb": "SelG; CG1844; G-rich", "gene_names_refseq": "BcDNA:GH03581; CG1844; Dmel\\CG1844; G-rich; SelG; SelK; dSelK; dselG; dselK", "protein_names_uniprotkb": "Glycine-rich selenoprotein; G-rich selenoprotein; dSelG", "protein_names_refseq": "CG1844-PA; G-rich protein; SelG-PA; Seleno-protein G; selenoprotein G", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1844)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;11389138;11493597;12537569;12537572;16920070", "class_list": "", "function": "Plays a role in the life span. May be involved in regulating the redox state of the cell and possesses anticarcinogenic properties., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2V8Y4;Q962X6;Q9VYS7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0010470 regulation of gastrulation;GO:0009792 embryo development ending in birth or egg hatching;GO:0006816 calcium ion transport;GO:0045454 cell redox homeostasis;GO:0032469 endoplasmic reticulum calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7Z2C4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VAT0-1", "uniprot_id": [ { "id": "Q9VAT0_DROME", "url": "https://www.uniprot.org/uniprot/Q9VAT0", "type": "external" } ], "mass": 56974.0, "length": 527, "protein_name": "WASp, isoform A; WASp, isoform B; WASp, isoform D", "gene_name": "WASp", "organism": "Fruit fly", "refseq_name": "WASp, isoform D", "refseq_ac": [ { "id": "NP_001263045", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263045", "type": "external" } ], "gene_names_uniprotkb": "WASp; CG1520; D-WASP; Dm WASP; DmWASP; Dmel\\CG1520; Dmel_CG1520; N-WASP; WASP; WSP; Wasp; Wsp; dWASP; wasp; wsp", "gene_names_refseq": "CG1520; D-WASP; Dm WASP; DmWASP; Dmel\\CG1520; N-WASP; WASP; WASp; WSP; Wasp; Wsp; dWASP; wasp; wsp", "protein_names_uniprotkb": "WASp, isoform A; WASp, isoform B; WASp, isoform D", "protein_names_refseq": "CG1520-PD; WASP; WASp, isoform D; WASp-PD; Wiscott-Aldrich syndrome protein; Wiskott-Aldrich syndrome protein", "tax_id": 7227, "disease": "X-linked severe congenital neutropenia (Disease Ontology:DOID:0112128); thrombocytopenia (Disease Ontology:DOID:1588); IgA glomerulonephritis (Disease Ontology:DOID:2986); atopic dermatitis (Disease Ontology:DOID:3310); Wiskott-Aldrich syndrome (Disease Ontology:DOID:9169)", "pathway": " (dme:Dmel_CG1520)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005902 microvillus;GO:0032991 protein-containing complex", "go_biological_process": "GO:0009913 epidermal cell differentiation;GO:0006886 intracellular protein transport;GO:0007409 axonogenesis;GO:0007286 spermatid development;GO:0007520 myoblast fusion", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VAT0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q86BF9-1", "uniprot_id": [ { "id": "OB59A_DROME", "url": "https://www.uniprot.org/uniprot/Q86BF9", "type": "external" } ], "mass": 23361.0, "length": 202, "protein_name": "Odorant-binding protein 59a", "gene_name": "Obp59a", "organism": "Fruit fly", "refseq_name": "Odorant-binding protein 59a", "refseq_ac": [ { "id": "NP_788429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788429", "type": "external" } ], "gene_names_uniprotkb": "Obp59a; CG13517; Obp58a", "gene_names_refseq": "59a; CG13517; DmelObp59a; Dmel\\CG13517; OBP59a; Obp58a; Obp59a", "protein_names_uniprotkb": "Odorant-binding protein 59a", "protein_names_refseq": "CG13517-PB; Obp59a-PB; Odorant-binding protein 59a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13517)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;30230472", "class_list": "", "function": "Odorant-binding protein required for hygrotaxis behavior in humidity-detecting sensilla., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q29QE9", "ec_number_list": [], "go_molecular_function": "GO:0005549 odorant binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007606 sensory perception of chemical stimulus;GO:0090547 response to low humidity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q86BF9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q86BL4-1", "uniprot_id": [ { "id": "GATC_DROME", "url": "https://www.uniprot.org/uniprot/Q86BL4", "type": "external" } ], "mass": 16869.0, "length": 148, "protein_name": "Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial", "gene_name": "GatC", "organism": "Fruit fly", "refseq_name": "Glutamyl-tRNA amidotransferase, subunit C", "refseq_ac": [ { "id": "NP_001027263", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027263", "type": "external" } ], "gene_names_uniprotkb": "GatC; CG33649", "gene_names_refseq": "CG33084-ORFA; CG33084; CG33649; CG8969; Dmel\\CG33649; GatC", "protein_names_uniprotkb": "Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial; 6.3.5.-; Glu-AdT subunit C", "protein_names_refseq": "CG33649-PA; GatC-PA; Glutamyl-tRNA amidotransferase, subunit C; glutamyl-tRNA amidotransferase subunit C", "tax_id": 7227, "disease": "combined oxidative phosphorylation deficiency 42 (Disease Ontology:DOID:0112118)", "pathway": " (dme:Dmel_CG33649)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.3.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.5.-", "type": "external" }, { "id": "6.3.5.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.5.7", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex", "go_biological_process": "GO:0032543 mitochondrial translation;GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation;GO:0006450 regulation of translational fidelity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q86BL4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q86BN8-1", "uniprot_id": [ { "id": "PTPM1_DROME", "url": "https://www.uniprot.org/uniprot/Q86BN8", "type": "external" } ], "mass": 23156.0, "length": 200, "protein_name": "Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1", "gene_name": "PTPMT1", "organism": "Fruit fly", "refseq_name": "protein tyrosine phosphatase, mitochondrial 1, isoform B", "refseq_ac": [ { "id": "NP_651180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651180", "type": "external" } ], "gene_names_uniprotkb": "PTPMT1; CG10371; Plip", "gene_names_refseq": "150466_at; CG10371; Dmel\\CG10371; PLIP; PTPMT1; Plip; dPTEN; dPTPMT1; plip", "protein_names_uniprotkb": "Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1; 3.1.3.16; 3.1.3.27; 3.1.3.48; PTEN-like phosphatase; PTEN-like protein; Protein-tyrosine phosphatase mitochondrial 1-like protein", "protein_names_refseq": "CG10371-PB; MKP-like; PTEN-like phosphatase; PTPMT1-PB; protein tyrosine phosphatase, mitochondrial 1, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10371)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;15247229", "class_list": "", "function": "Lipid phosphatase that may mediate dephosphorylation of mitochondrial proteins (By similarity). Protein phosphatase that may mediate dephosphorylation of mitochondrial proteins (By similarity). Does not dephosphorylate Akt., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SZ90;Q9VCI6", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0008962 phosphatidylglycerophosphatase activity;GO:0004725 protein tyrosine phosphatase activity;GO:0102091 phosphatidylinositol-5-phosphate phosphatase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032049 cardiolipin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q86BN8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8I8U7-1", "uniprot_id": [ { "id": "TRA1_DROME", "url": "https://www.uniprot.org/uniprot/Q8I8U7", "type": "external" } ], "mass": 435330.0, "length": 3790, "protein_name": "Transcription-associated protein 1", "gene_name": "Nipped-A", "organism": "Fruit fly", "refseq_name": "Nipped-A, isoform E", "refseq_ac": [ { "id": "NP_001097192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097192", "type": "external" } ], "gene_names_uniprotkb": "Nipped-A; CG2905; Tra1", "gene_names_refseq": "41Ah; CG10549; CG2905; CG33554; DmTrrap; Dmel\\CG33554; GroupV; Nip-A; NipA; Nipped A; Nipped-A; Nipped[A]; TRA1; TRRAP; Tra-1; Tra1; dTRRAP; dTra1; dmTRRAP; l(2)41Ah; l(2)C123; l(2)EMS34-12; nipped-a; tra1", "protein_names_uniprotkb": "Transcription-associated protein 1; dTRA1", "protein_names_refseq": "CG33554-PE; Nipped-A, isoform E; Nipped-A-PE; NippedA; lethal(2)41Ah; nipped", "tax_id": 7227, "disease": "autosomal dominant nonsyndromic deafness (Disease Ontology:DOID:0050564); autosomal dominant nonsyndromic deafness 75 (Disease Ontology:DOID:0112166)", "pathway": " (dme:Dmel_CG33554); (R-DME-201722); (R-DME-5689880)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10731132;12537569;12537572;12697829;15528408;16508010;32432549", "class_list": "", "function": "Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of histone H4 'Lys-12' (PubMed:32432549). Part of the Tip60 chromatin-remodeling complex which is involved in DNA repair; upon induction of DNA double-strand breaks, this complex acetylates phosphorylated H2AV in nucleosomes and exchanges it with unmodified H2AV (PubMed:15528408). During wing development, required for activity of Notch and its coactivator mam (PubMed:16508010). Function in promoting mam function is likely to involve both the Tip60 and SAGA complexes (PubMed:16508010)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A140SQB4;A8DY44;Q2EZ47;Q8T3L7;Q9V9E9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0035267 NuA4 histone acetyltransferase complex;GO:0000123 histone acetyltransferase complex;GO:0000124 SAGA complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0035222 wing disc pattern formation;GO:0140861 DNA repair-dependent chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8I8U7-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8I8V0-1", "uniprot_id": [ { "id": "TAD2B_DROME", "url": "https://www.uniprot.org/uniprot/Q8I8V0", "type": "external" } ], "mass": 62031.0, "length": 555, "protein_name": "Transcriptional adapter 2b", "gene_name": "Ada2b", "organism": "Fruit fly", "refseq_name": "transcriptional adaptor 2b, isoform B", "refseq_ac": [ { "id": "NP_001027151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027151", "type": "external" } ], "gene_names_uniprotkb": "Ada2b; Ada2S; CG9638", "gene_names_refseq": "ADA2b; Ada2B; Ada2S; Ada2b; BcDNA:LD24527; CG9638; Dmel\\CG9638; ada2b; dADA2b; dAda2B; dAda2S; dAda2b", "protein_names_uniprotkb": "Transcriptional adapter 2b; dADA2b", "protein_names_refseq": "Ada2b-PB; CG9638-PB; transcriptional adapter 2S; transcriptional adaptor 2b, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9638); (R-DME-5689880)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12482983;12537569;12537572;12697829;15340070;16135810;19740772;22796493;23336284;30559249", "class_list": "", "function": "Component of several Gcn5-containing histone acetyltransferase complexes that regulate nucleosome organization; involved in acetylation of histone H3, particularly on Lys-10 (H3K9ac) and Lys-15 (H3K14ac) (PubMed:12482983, PubMed:12697829, PubMed:15340070, PubMed:19740772, PubMed:22796493). Regulates the transcription of a subset of genes during development; affects recruitment of RNA polymerase II (PubMed:19740772, PubMed:23336284). May be involved in the function of some acidic activation domains, which activate transcription at distant sites (PubMed:12697829). Involved in the p53-dependent apoptosis pathway response to DNA damage by genotoxic agents (PubMed:15340070, PubMed:16135810)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Component of the CHAT histone acetyltransferase complex, which predominantly acetylates histone H3., [UniProtKB, PubMed]; Component of the SAGA histone acetyltransferase complex, which predominantly acetylates histone H3., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4KFU2;Q9VHV0", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0070461 SAGA-type complex;GO:0005634 nucleus;GO:0000124 SAGA complex;GO:0005700 polytene chromosome", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8I8V0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IFW4-1", "uniprot_id": [ { "id": "THIOT_DROME", "url": "https://www.uniprot.org/uniprot/Q8IFW4", "type": "external" } ], "mass": 17489.0, "length": 157, "protein_name": "Thioredoxin-T", "gene_name": "TrxT", "organism": "Fruit fly", "refseq_name": "thioredoxin T, isoform B", "refseq_ac": [ { "id": "NP_001284881", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284881", "type": "external" } ], "gene_names_uniprotkb": "TrxT; CG3315", "gene_names_refseq": "3315; CG3315; DmTrxT; DmelTrxT; Dmel\\CG3315; TrxT; Trxt; trxt", "protein_names_uniprotkb": "Thioredoxin-T; ThioredoxinT", "protein_names_refseq": "CG3315-PB; ThioredoxinT; TrxT-PB; thioredoxin T, isoform B; thioredoxin", "tax_id": 7227, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); glaucoma (Disease Ontology:DOID:1686); myocardial infarction (Disease Ontology:DOID:5844); myocarditis (Disease Ontology:DOID:820); intermediate coronary syndrome (Disease Ontology:DOID:8805); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (dme:Dmel_CG3315)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;14579129", "class_list": "", "function": "Probably participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Its tissue specificity suggests a regulatory role in the germline., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C8VV89;Q9W4D6;X2JID2", "ec_number_list": [], "go_molecular_function": "GO:0015035 protein-disulfide reductase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000806 Y chromosome", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8IFW4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IN35-1", "uniprot_id": [ { "id": "SIFAR_DROME", "url": "https://www.uniprot.org/uniprot/Q8IN35", "type": "external" } ], "mass": 83442.0, "length": 758, "protein_name": "Neuropeptide SIFamide receptor", "gene_name": "SIFaR", "organism": "Fruit fly", "refseq_name": "SIFamide receptor, isoform C", "refseq_ac": [ { "id": "NP_001163674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163674", "type": "external" } ], "gene_names_uniprotkb": "SIFaR; CG10823; SIFR", "gene_names_refseq": "CG10823; Dmel\\CG10823; DrmSIFR; SIF-R; SIFR; SIFa-R; SIFaR; SIFamide R; SifaR; anon-WO0170980.43; anon-WO0170980.44", "protein_names_uniprotkb": "Neuropeptide SIFamide receptor", "protein_names_refseq": "CG10823-PC; SIFaR-PC; SIFamide receptor, isoform C; SIFamide receptor; SIFamide-receptor", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10823)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537572;16378592;24658384;26469541", "class_list": "", "function": "Receptor for the neuropeptide SIFamide (PubMed:16378592). Modulates sexual behavior by playing a role in male sex discrimination (PubMed:26469541). Also involved in promoting sleep (PubMed:24658384)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q7YU49", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008188 neuropeptide receptor activity;GO:0004983 neuropeptide Y receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0060179 male mating behavior;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0032870 cellular response to hormone stimulus;GO:0048047 mating behavior, sex discrimination", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8IN35-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IN41-1", "uniprot_id": [ { "id": "TOTX_DROME", "url": "https://www.uniprot.org/uniprot/Q8IN41", "type": "external" } ], "mass": 16369.0, "length": 142, "protein_name": "Protein Turandot X", "gene_name": "TotX", "organism": "Fruit fly", "refseq_name": "turandot X", "refseq_ac": [ { "id": "NP_536781", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536781", "type": "external" } ], "gene_names_uniprotkb": "TotX; CG31193", "gene_names_refseq": "CG31193; Dmel\\CG31193; TOTX; Tot X; TotX; Totx; totX; tot", "protein_names_uniprotkb": "Protein Turandot X", "protein_names_refseq": "CG31193-PA; TotX-PA; turandot X; turandot", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31193)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;11409894;12537572", "class_list": "", "function": "A humoral factor that may play a role in stress tolerance., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q962D6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0045087 innate immune response;GO:0034605 cellular response to heat;GO:0009617 response to bacterium;GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8IN41-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IN43-1", "uniprot_id": [ { "id": "TOTC_DROME", "url": "https://www.uniprot.org/uniprot/Q8IN43", "type": "external" } ], "mass": 14296.0, "length": 129, "protein_name": "Protein Turandot C", "gene_name": "TotC", "organism": "Fruit fly", "refseq_name": "turandot C", "refseq_ac": [ { "id": "NP_536779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536779", "type": "external" } ], "gene_names_uniprotkb": "TotC; CG31508", "gene_names_refseq": "CG31508; Dmel\\CG31508; TOTc; TotC; totC; tot", "protein_names_uniprotkb": "Protein Turandot C", "protein_names_refseq": "CG31508-PA; Stress-inducible humoral factor turandot C; TotC-PA; turandot C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31508)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;11409894;12537572", "class_list": "", "function": "A humoral factor that may play a role in stress tolerance., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q962D9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0045087 innate immune response;GO:0034605 cellular response to heat;GO:0009617 response to bacterium;GO:0009411 response to UV", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8IN43-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IN58-1", "uniprot_id": [ { "id": "GR92A_DROME", "url": "https://www.uniprot.org/uniprot/Q8IN58", "type": "external" } ], "mass": 45384.0, "length": 386, "protein_name": "Putative gustatory receptor 92a", "gene_name": "Gr92a", "organism": "Fruit fly", "refseq_name": "gustatory receptor 92a", "refseq_ac": [ { "id": "NP_732489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_732489", "type": "external" } ], "gene_names_uniprotkb": "Gr92a; CG31208", "gene_names_refseq": "CG31208; DmGr92a; Dmel\\CG31208; GR92a; Gr92D1; Gr92a", "protein_names_uniprotkb": "Putative gustatory receptor 92a", "protein_names_refseq": "CG31208-PA; Gr92a-PA; gustatory receptor 92D1; gustatory receptor 92a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31208)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;11516643;12537572", "class_list": "", "function": "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0008527 taste receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0034220 monoatomic ion transmembrane transport;GO:0050909 sensory perception of taste", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8IN58-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8INF2-1", "uniprot_id": [ { "id": "TAM41_DROME", "url": "https://www.uniprot.org/uniprot/Q8INF2", "type": "external" } ], "mass": 38219.0, "length": 342, "protein_name": "Phosphatidate cytidylyltransferase, mitochondrial", "gene_name": "CG33331; CG3641", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_996213", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996213", "type": "external" } ], "gene_names_uniprotkb": "CG33331; CG3641", "gene_names_refseq": "BcDNA:SD17447; CG33331; CG3641; Dmel\\CG33331; Tam41", "protein_names_uniprotkb": "Phosphatidate cytidylyltransferase, mitochondrial; 2.7.7.41; CDP-DAG synthase; CDP-diacylglycerol synthase; Mitochondrial translocator assembly and maintenance protein 41 homolog; TAM41", "protein_names_refseq": "CG33331-PA; uncharacterized protein", "tax_id": 7227, "disease": "combined oxidative phosphorylation deficiency 56 (Disease Ontology:DOID:0070429); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (dme:Dmel_CG33331)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NN16", "ec_number_list": [ { "id": "2.7.7.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.41", "type": "external" } ], "go_molecular_function": "GO:0004605 phosphatidate cytidylyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0016024 CDP-diacylglycerol biosynthetic process;GO:0032049 cardiolipin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8INF2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8INK9-1", "uniprot_id": [ { "id": "MSRB_DROME", "url": "https://www.uniprot.org/uniprot/Q8INK9", "type": "external" } ], "mass": 23299.0, "length": 208, "protein_name": "Methionine-R-sulfoxide reductase B1", "gene_name": "SelR", "organism": "Fruit fly", "refseq_name": "selenoprotein R, isoform G", "refseq_ac": [ { "id": "NP_001138036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138036", "type": "external" } ], "gene_names_uniprotkb": "SelR; CG6584; MsrB1; MsrB", "gene_names_refseq": "BcDNA:RE36040; BcDNA:RH61230; CG6584; Dmel\\CG6584; EP3340; MSRB; MsrB; SelR; dMsrB; selR", "protein_names_uniprotkb": "Methionine-R-sulfoxide reductase B1; 1.8.4.12; Selenoprotein R", "protein_names_refseq": "CG6584-PG; EP3340; SelR-PG; methionine-R-sulfoxide reductase; selenoprotein R, isoform G", "tax_id": 7227, "disease": "autosomal recessive nonsyndromic deafness 74 (Disease Ontology:DOID:0110523)", "pathway": " (dme:Dmel_CG6584); (R-DME-5676934)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10731132;11929995;12145281;12537569;12537572;24212093", "class_list": "", "function": "Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by Mical on actin thereby promoting filament repolymerization., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V2P1;B7Z0V7;Q53XF3;Q8IGC0;Q8IGS8;Q8INK8;Q8INL0;Q8STJ0;Q9VGV4", "ec_number_list": [ { "id": "1.8.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.12", "type": "external" } ], "go_molecular_function": "GO:0033743 peptide-methionine (R)-S-oxide reductase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0007015 actin filament organization;GO:0030041 actin filament polymerization;GO:0007411 axon guidance;GO:0030091 protein repair", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8INK9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8INM3-1", "uniprot_id": [ { "id": "SLE_DROME", "url": "https://www.uniprot.org/uniprot/Q8INM3", "type": "external" } ], "mass": 158654.0, "length": 1420, "protein_name": "Protein slender lobes", "gene_name": "sle", "organism": "Fruit fly", "refseq_name": "slender lobes, isoform B", "refseq_ac": [ { "id": "NP_731472", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_731472", "type": "external" } ], "gene_names_uniprotkb": "sle; CG12819", "gene_names_refseq": "CG12819-PA; CG12819; Dmel\\CG12819; FBtr0082231; SLE; Sle; sle", "protein_names_uniprotkb": "Protein slender lobes", "protein_names_refseq": "CG12819-PB; sle-PB; slender lobes, isoform B; slender lobe", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12819)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;15848394;17372656;18327897", "class_list": "", "function": "Required for the correct organization of the nucleolus during development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 88, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NLK7;Q6YNC4;Q95TF8;Q9VGZ9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0007000 nucleolus organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8INM3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8INV7-1", "uniprot_id": [ { "id": "TOTE_DROME", "url": "https://www.uniprot.org/uniprot/Q8INV7", "type": "external" } ], "mass": 14736.0, "length": 134, "protein_name": "Protein Turandot E", "gene_name": "TotE", "organism": "Fruit fly", "refseq_name": "turandot E", "refseq_ac": [ { "id": "NP_788077", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788077", "type": "external" } ], "gene_names_uniprotkb": "TotE; CG33117; Victoria", "gene_names_refseq": "CG13963; CG33117; Dmel\\CG33117; TotE; Victoria; victoria", "protein_names_uniprotkb": "Protein Turandot E; Protein Victoria", "protein_names_refseq": "CG33117-PA; TotE-PA; turandot E; victoria", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33117)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;11409894;12537572", "class_list": "", "function": "A humoral factor that may play a role in stress tolerance., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q962E1;Q962F4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0045087 innate immune response;GO:0034605 cellular response to heat;GO:0009617 response to bacterium;GO:0009408 response to heat;GO:0034644 cellular response to UV", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8INV7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q94887-1", "uniprot_id": [ { "id": "NRX4_DROME", "url": "https://www.uniprot.org/uniprot/Q94887", "type": "external" } ], "mass": 145468.0, "length": 1284, "protein_name": "Neurexin-4", "gene_name": "Nrx-IV", "organism": "Fruit fly", "refseq_name": "neurexin IV, isoform A", "refseq_ac": [ { "id": "NP_524034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524034", "type": "external" } ], "gene_names_uniprotkb": "Nrx-IV; CG6827; CG682; CNTNAP2; CT21123; Dmel\\CG6827; Dmel_CG6827; Dnrx; NRX IV; NRX; Nrx IV; Nrx4; NrxIV; Nrx; Nx IV; l(3)68Ff; l(3)rsg23; neurexin; nrx IV; nrx-IV; nrx-iv; nrx4; nrxIV; nrx; rsg23", "gene_names_refseq": "CG6827; CG682; CNTNAP2; CT21123; Dmel\\CG6827; Dnrx; NRX IV; NRX; Nrx IV; Nrx-IV; Nrx4; NrxIV; Nrx; Nx IV; l(3)68Ff; l(3)rsg23; neurexin; nrx IV; nrx-IV; nrx-iv; nrx4; nrxIV; nrx; rsg23", "protein_names_uniprotkb": "Neurexin-4; Neurexin IV", "protein_names_refseq": "CG6827-PA; Neurexin-4; Neurexin-IV; Nrx-IV-PA; neurexin 4; neurexin IV, isoform A; neurexin IV; neurexinIV; neurexin; rose-gespleten region interval 23", "tax_id": 7227, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); specific language impairment (Disease Ontology:DOID:0060244); autosomal recessive intellectual developmental disorder (Disease Ontology:DOID:0060308); lethal congenital contracture syndrome (Disease Ontology:DOID:0060558); cortical dysplasia-focal epilepsy syndrome (Disease Ontology:DOID:0090130); social phobia (Disease Ontology:DOID:11257); autistic disorder (Disease Ontology:DOID:12849); reading disorder (Disease Ontology:DOID:13365); major depressive disorder (Disease Ontology:DOID:1470); epilepsy (Disease Ontology:DOID:1826); articulation disorder (Disease Ontology:DOID:4186); mutism (Disease Ontology:DOID:4189); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dme:Dmel_CG6827)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10102271;10731132;12537568;12537572;12537573;12537574;15459097;16110336;17569856;17569867;17893096;20935638;25589440;26109356;26109357;8978610;9508778", "class_list": "", "function": "Seems to play a role in the formation and function of septate junctions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. Required for the blood-brain barrier formation., [UniProtKB, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q9VTU5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0048786 presynaptic active zone;GO:0005919 pleated septate junction;GO:0016020 membrane", "go_biological_process": "GO:0072553 terminal button organization;GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0008104 intracellular protein localization;GO:0008366 axon ensheathment", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q94887-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IRG6-1", "uniprot_id": [ { "id": "SPT16_DROME", "url": "https://www.uniprot.org/uniprot/Q8IRG6", "type": "external" } ], "mass": 123583.0, "length": 1083, "protein_name": "FACT complex subunit spt16", "gene_name": "dre4", "organism": "Fruit fly", "refseq_name": "dre4, isoform A", "refseq_ac": [ { "id": "NP_476610", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476610", "type": "external" } ], "gene_names_uniprotkb": "dre4; CG1828; spt16", "gene_names_refseq": "CG1828; DRE4/dSPT16; DRE4; Dmel\\CG1828; Dre4; SPT16; Spt16; dSPT16; dSpt16; dre4; dspt16; l(3)62Bg; l(3)dre4; spt16", "protein_names_uniprotkb": "FACT complex subunit spt16; Facilitates chromatin transcription complex subunit SPT16; dSPT16", "protein_names_refseq": "CG1828-PA; dre4, isoform A; dre4-PA; lethal(3)62Bg; supressor of Ty element 16", "tax_id": 7227, "disease": "neurodevelopmental disorder with dysmorphic facies and thin corpus callosum (Disease Ontology:DOID:0070469)", "pathway": " (dme:Dmel_CG1828); (R-DME-112382); (R-DME-674695); (R-DME-6796648); (R-DME-6804756); (R-DME-75955); (R-DME-9943411)", "pathway_count": 7, "publication_count": 6, "publication_id_list": "10731132;12537572;12815073;12934007;1551577;18327897", "class_list": "", "function": "Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is required for expression of Hox genes., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O17045;O17046;Q7YTY1;Q86SB9;Q9W071", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0046982 protein heterodimerization activity;GO:0031491 nucleosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0035101 FACT complex;GO:0005703 polytene chromosome puff", "go_biological_process": "GO:0034728 nucleosome organization;GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8IRG6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IRR1-1", "uniprot_id": [ { "id": "VNNL2_DROME", "url": "https://www.uniprot.org/uniprot/Q8IRR1", "type": "external" } ], "mass": 59549.0, "length": 525, "protein_name": "Vanin-like protein 2", "gene_name": "CG32751; CG3648", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001284927", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284927", "type": "external" } ], "gene_names_uniprotkb": "CG32751; CG3648", "gene_names_refseq": "CG32751; CG3648; Dmel\\CG32751", "protein_names_uniprotkb": "Vanin-like protein 2; 3.5.1.-", "protein_names_refseq": "CG32751-PB; pantetheine hydrolase; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); biotinidase deficiency (Disease Ontology:DOID:856)", "pathway": " (dme:Dmel_CG32751)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;25387828", "class_list": "", "function": "", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "D5SHR9;X2JDW2", "ec_number_list": [], "go_molecular_function": "GO:0017159 pantetheine hydrolase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8IRR1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IRR5-1", "uniprot_id": [ { "id": "SIR4_DROME", "url": "https://www.uniprot.org/uniprot/Q8IRR5", "type": "external" } ], "mass": 34991.0, "length": 312, "protein_name": "NAD-dependent protein deacylase Sirt4", "gene_name": "Sirt4", "organism": "Fruit fly", "refseq_name": "sirtuin 4, isoform C", "refseq_ac": [ { "id": "NP_572241", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572241", "type": "external" } ], "gene_names_uniprotkb": "Sirt4; CG3187", "gene_names_refseq": "CG3187; D.mel3; Dmel\\CG3187; SIRT4; Sirt4; dSIRT4; dSirt4; dmSRT407", "protein_names_uniprotkb": "NAD-dependent protein deacylase Sirt4; 2.3.1.286; Regulatory protein SIR2 homolog 4", "protein_names_refseq": "CG3187-PC; Sirt4-PC; sirtuin 4, isoform C", "tax_id": 7227, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208)", "pathway": " (dme:Dmel_CG3187); (R-DME-204174); (R-DME-2151201)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D0IQB9;Q9W4A1", "ec_number_list": [ { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.12", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0070403 NAD+ binding;GO:0004407 histone deacetylase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity;GO:0017136 histone deacetylase activity, NAD-dependent", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0009267 cellular response to starvation;GO:0008340 determination of adult lifespan", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8IRR5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8ITC9-1", "uniprot_id": [ { "id": "PK1R_DROME", "url": "https://www.uniprot.org/uniprot/Q8ITC9", "type": "external" } ], "mass": 47317.0, "length": 430, "protein_name": "Pyrokinin-1 receptor", "gene_name": "PK1-R", "organism": "Fruit fly", "refseq_name": "pyrokinin 1 receptor, isoform D", "refseq_ac": [ { "id": "NP_001014620", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014620", "type": "external" } ], "gene_names_uniprotkb": "PK1-R; CG9918", "gene_names_refseq": "CG9918; Dmel\\CG9918; LstR; PK1-R; PK1R; PK1r; Pk1R; Pk1r; anon-WO0170980.112; anon-WO0170980.113; pkr1", "protein_names_uniprotkb": "Pyrokinin-1 receptor", "protein_names_refseq": "CG9918-PD; CPyrokinin 1 receptor; Drm-PK-1 receptor; Lst receptor; PK1-R-PD; pyrokinin 1 R; pyrokinin 1 receptor, isoform D; pyrokinin receptor 1; pyrokinin-1 receptor", "tax_id": 7227, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG9918)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12177421;12537572;16054112", "class_list": "", "function": "Receptor for the neuropeptide CAP-3/pyrokinin-1 (TGPSASSGLWFGPRL-amide) (PubMed:16054112). Also activated weakly by other neuropeptides terminating in the sequence PRL-amide including pyrokinin-2, Hug-gamma, and ecdysis-triggering-hormone-1 (PubMed:12177421, PubMed:16054112). The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system (PubMed:16054112)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0IGX8;Q71RH8", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008188 neuropeptide receptor activity;GO:0036401 pyrokinin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0070328 triglyceride homeostasis;GO:0090278 negative regulation of peptide hormone secretion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8ITC9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8MKK0-1", "uniprot_id": [ { "id": "OB57A_DROME", "url": "https://www.uniprot.org/uniprot/Q8MKK0", "type": "external" } ], "mass": 19462.0, "length": 169, "protein_name": "General odorant-binding protein 57a", "gene_name": "Obp57a", "organism": "Fruit fly", "refseq_name": "Odorant-binding protein 57a", "refseq_ac": [ { "id": "NP_725966", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_725966", "type": "external" } ], "gene_names_uniprotkb": "Obp57a; CG30141", "gene_names_refseq": "57a; CG30141; DmelObp57a; Dmel\\CG30141; OBP57a; Obp-f; Obp57a; Obp57c; anon-AE003792.1; obp57a", "protein_names_uniprotkb": "General odorant-binding protein 57a", "protein_names_refseq": "CG30141-PA; Obp57a-PA; Odorant-binding protein 57a; general odorant-binding protein 57a precursor", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG30141)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12119098;12213773;12537572", "class_list": "", "function": "Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V3M7", "ec_number_list": [], "go_molecular_function": "GO:0005549 odorant binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007608 sensory perception of smell;GO:0007606 sensory perception of chemical stimulus;GO:1990834 response to odorant", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8MKK0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8MKW7-1", "uniprot_id": [ { "id": "RNZ_DROME", "url": "https://www.uniprot.org/uniprot/Q8MKW7", "type": "external" } ], "mass": 85492.0, "length": 766, "protein_name": "Ribonuclease Z, mitochondrial", "gene_name": "RNaseZ", "organism": "Fruit fly", "refseq_name": "ribonuclease Z", "refseq_ac": [ { "id": "NP_724916", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_724916", "type": "external" } ], "gene_names_uniprotkb": "RNaseZ; CG3298; JhI-1", "gene_names_refseq": "CG3298; Dmel\\CG3298; JHI-1; JhI-1; RNZ; RNaseZ; dRNase Z; dRNaseZ; dtRNaseZ; jhI-1; tRNAse Z; tRNAseZ; tRNase Z[L]; tRNase Z", "protein_names_uniprotkb": "Ribonuclease Z, mitochondrial; 3.1.26.11; DmeZ; Juvenile hormone-inducible protein 1; RNase Z; dRNAse Z; tRNA 3 endonuclease; tRNase Z", "protein_names_refseq": "CG3298-PB; RNaseZ-PB; juvenile hormone-inducible protein 1; ribonuclease Z; tRNA 3'-processing endonuclease; tRNase Z", "tax_id": 7227, "disease": "mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); combined oxidative phosphorylation deficiency 17 (Disease Ontology:DOID:0111496); infantile hypertrophic cardiomyopathy (Disease Ontology:DOID:0111753); prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (dme:Dmel_CG3298)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;10926782;12537569;12537572;14715923", "class_list": "", "function": "Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity of nuclear and mitochondrial pre-tRNA. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. May participate in tRNA processing in the developing embryo., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MRT4;Q9GZ73", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0042781 3'-tRNA processing endoribonuclease activity;GO:0016891 RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0030307 positive regulation of cell growth;GO:0001558 regulation of cell growth;GO:0045727 positive regulation of translation;GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation;GO:0036093 germ cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8MKW7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8MQW8-1", "uniprot_id": [ { "id": "SPRI_DROME", "url": "https://www.uniprot.org/uniprot/Q8MQW8", "type": "external" } ], "mass": 193318.0, "length": 1789, "protein_name": "Protein sprint", "gene_name": "spri", "organism": "Fruit fly", "refseq_name": "sprint, isoform J", "refseq_ac": [ { "id": "NP_001096941", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096941", "type": "external" } ], "gene_names_uniprotkb": "spri; CG33175; CG34414", "gene_names_refseq": "CG12638; CG15297; CG15298; CG15299; CG15300; CG15301; CG32674; CG32680; CG33175; CG34414; Dmel\\CG34414; Rin1; Spri; anon-WO03040301.275; spri", "protein_names_uniprotkb": "Protein sprint; SH2 poly-proline-containing Ras-interactor protein", "protein_names_refseq": "CG34414-PJ; spri-PJ; sprint, isoform J; sprint-a; sprint-b; sprint", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG34414); (R-DME-8876198)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;11231087;12537569;12537572", "class_list": "", "function": "Potential Ras effector protein. May function as a guanine nucleotide exchange (GEF), by exchanging bound GDP for free GTP (By similarity)., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "M9PE83;M9PGU3;M9PH67;M9PHI9;M9PJH2;M9PJH3;Q3KN60;Q8MQV9;Q8T4E9;Q9BK48;Q9BK49;Q9W2T4;Q9W2T7;Q9W2U1;T2GGG1", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0019901 protein kinase binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding;GO:0030971 receptor tyrosine kinase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005938 cell cortex;GO:0030139 endocytic vesicle", "go_biological_process": "GO:0032483 regulation of Rab protein signal transduction;GO:0007165 signal transduction;GO:0016192 vesicle-mediated transport;GO:0048260 positive regulation of receptor-mediated endocytosis;GO:0048675 axon extension", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8MQW8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8MS27-1", "uniprot_id": [ { "id": "RM35_DROME", "url": "https://www.uniprot.org/uniprot/Q8MS27", "type": "external" } ], "mass": 20473.0, "length": 178, "protein_name": "Large ribosomal subunit protein bL35m", "gene_name": "mRpL35", "organism": "Fruit fly", "refseq_name": "mitochondrial ribosomal protein L35", "refseq_ac": [ { "id": "NP_651001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651001", "type": "external" } ], "gene_names_uniprotkb": "mRpL35; CG13410", "gene_names_refseq": "BcDNA:RE35766; CG13410; Dmel\\CG13410; MRP-L35; mRpL35", "protein_names_uniprotkb": "Large ribosomal subunit protein bL35m; 39S ribosomal protein L35, mitochondrial; L35mt; MRP-L35", "protein_names_refseq": "CG13410-PA; mRpL35-PA; mitochondrial ribosomal protein L35", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13410); (R-DME-5389840); (R-DME-5419276); (R-DME-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9VD57", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8MS27-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8MSU4-1", "uniprot_id": [ { "id": "SYMPK_DROME", "url": "https://www.uniprot.org/uniprot/Q8MSU4", "type": "external" } ], "mass": 132077.0, "length": 1165, "protein_name": "Symplekin", "gene_name": "Sym", "organism": "Fruit fly", "refseq_name": "symplekin", "refseq_ac": [ { "id": "NP_649580", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649580", "type": "external" } ], "gene_names_uniprotkb": "Sym; CG2097", "gene_names_refseq": "CG2097; Dmel\\CG2097; Symp; Sym; dSymp; symplekin", "protein_names_uniprotkb": "Symplekin", "protein_names_refseq": "CG2097-PA; Sym-PA; symplekin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2097); (R-DME-159231); (R-DME-73856); (R-DME-77595); (R-DME-9770562)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "10731132;12537569;12537572;18042462;19450530;19576221;28190776;29317541;40245499", "class_list": "", "function": "Component of a protein complex required for cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA (PubMed:18042462, PubMed:19450530). Involved in germline stem cell transit amplification, differentiation and mitosis-to-meiosis transition (PubMed:28190776)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9VNH4", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex;GO:0061689 tricellular tight junction;GO:0035363 histone locus body", "go_biological_process": "GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage;GO:0071045 nuclear histone mRNA catabolic process;GO:0180010 co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8MSU4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8SX86-1", "uniprot_id": [ { "id": "NUTC_DROME", "url": "https://www.uniprot.org/uniprot/Q8SX86", "type": "external" } ], "mass": 36487.0, "length": 314, "protein_name": "Protein nutcracker", "gene_name": "ntc", "organism": "Fruit fly", "refseq_name": "nutcracker", "refseq_ac": [ { "id": "NP_647829", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647829", "type": "external" } ], "gene_names_uniprotkb": "ntc; CG10855", "gene_names_refseq": "CG10855; Dmel\\CG10855; FBXO7; ntc", "protein_names_uniprotkb": "Protein nutcracker", "protein_names_refseq": "CG10855-PA; ntc-PA; nutcracker", "tax_id": 7227, "disease": "Parkinson's disease 15 (Disease Ontology:DOID:0060372)", "pathway": " (dme:Dmel_CG10855)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;20392747;21529711", "class_list": "", "function": "Functions together with PI31 to control non-apoptotic caspase activation during sperm individualization. Positively regulates PI31 stability., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VZM8", "ec_number_list": [], "go_molecular_function": "GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:1901526 positive regulation of mitophagy;GO:0050821 protein stabilization;GO:0016567 protein ubiquitination;GO:0007291 sperm individualization;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8SX86-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8SY33-1", "uniprot_id": [ { "id": "GAWKY_DROME", "url": "https://www.uniprot.org/uniprot/Q8SY33", "type": "external" } ], "mass": 142973.0, "length": 1384, "protein_name": "Protein Gawky", "gene_name": "gw", "organism": "Fruit fly", "refseq_name": "gawky, isoform J", "refseq_ac": [ { "id": "NP_001014691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014691", "type": "external" } ], "gene_names_uniprotkb": "gw; CG31992; GW182", "gene_names_refseq": "CG11484; CG31992; CG9905; Dmel\\CG31992; GQ182; GW182; GW; Gw182; Gw; anon-EST:Posey205; dGW182; gw182; gw", "protein_names_uniprotkb": "Protein Gawky", "protein_names_refseq": "CG31992-PJ; gawki; gawky, isoform J; gawky; gw-PJ", "tax_id": 7227, "disease": "familial adult myoclonic epilepsy 6 (Disease Ontology:DOID:0111696); uterine fibroid (Disease Ontology:DOID:13223); subserous uterine fibroid (Disease Ontology:DOID:13560)", "pathway": " (dme:Dmel_CG31992); (R-DME-426496); (R-DME-5578749)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10731132;12537569;12537572;16177138;16815998;16880270;18345015;19295135;19304924;19383769;19451544;19797087;20530530;21981923;40245499", "class_list": "", "function": "Required for gene silencing mediated by micro-RNAs (miRNAs). Silences both polyadenylated and deadenylated mRNAs. Required for miRNA-mediated translational repression and mRNA decay. Not required for miRNA target recognition. Necessary to initiate but not to maintain silencing. Promotes mRNA deadenylation through the recruitment of the CCR4-NOT and PAN complexes and promotes decapping by the DCP1-DCP2 complex. Dissociates from silenced mRNAs after deadenylation. Required for completion of nuclear divisions during early embryonic development., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q8MSF0;Q9V4F1", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000932 P-body;GO:0016442 RISC complex", "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:0032880 regulation of protein localization;GO:0006402 mRNA catabolic process;GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing;GO:0035278 miRNA-mediated gene silencing by inhibition of translation", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q8SY33-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8SY72-1", "uniprot_id": [ { "id": "SMCO4_DROME", "url": "https://www.uniprot.org/uniprot/Q8SY72", "type": "external" } ], "mass": 6648.0, "length": 58, "protein_name": "Single-pass membrane and coiled-coil domain-containing protein 4 homolog", "gene_name": "CG33169", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform C", "refseq_ac": [ { "id": "NP_001137999", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137999", "type": "external" } ], "gene_names_uniprotkb": "CG33169", "gene_names_refseq": "BcDNA:RH56317; CG33169; CG8244; Dmel\\CG33169; EP3524", "protein_names_uniprotkb": "Single-pass membrane and coiled-coil domain-containing protein 4 homolog", "protein_names_refseq": "CG33169-PC; uncharacterized protein, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33169)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7Z0A1;Q86BG4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8SY72-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8SYK5-1", "uniprot_id": [ { "id": "INSV_DROME", "url": "https://www.uniprot.org/uniprot/Q8SYK5", "type": "external" } ], "mass": 42215.0, "length": 376, "protein_name": "Protein insensitive", "gene_name": "insv", "organism": "Fruit fly", "refseq_name": "insensitive, isoform B", "refseq_ac": [ { "id": "NP_001285566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285566", "type": "external" } ], "gene_names_uniprotkb": "insv; CG3227", "gene_names_refseq": "BcDNA:RE55538; CG3227; Dmel\\CG3227; Insv; insv", "protein_names_uniprotkb": "Protein insensitive", "protein_names_refseq": "CG3227-PB; insensitive, isoform B; insensitive; insv-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3227)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;21765394;23468431;25561495", "class_list": "", "function": "Can act as both a transcriptional repressor and corepressor. Represses the expression of genes involved in neural development and preferentially binds palindromic sequence 5'-CCAATTGG-3' to mediate transcriptional repression (PubMed:23468431, PubMed:25561495). Acts as a corepressor for suppressor of hairless (Su(H)) and inhibits Notch signaling during peripheral nervous system development (PubMed:21765394, PubMed:25561495)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9VQD5", "ec_number_list": [], "go_molecular_function": "GO:0043035 chromatin insulator sequence binding;GO:0003714 transcription corepressor activity;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045666 positive regulation of neuron differentiation;GO:0045892 negative regulation of DNA-templated transcription;GO:0045746 negative regulation of Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8SYK5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8SYS7-1", "uniprot_id": [ { "id": "NARF_DROME", "url": "https://www.uniprot.org/uniprot/Q8SYS7", "type": "external" } ], "mass": 54534.0, "length": 477, "protein_name": "Probable cytosolic Fe-S cluster assembly factor CG17683", "gene_name": "CG17683", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform E", "refseq_ac": [ { "id": "NP_001036427", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036427", "type": "external" } ], "gene_names_uniprotkb": "CG17683", "gene_names_refseq": "CG17683; Dmel\\CG17683; NAR1p; NC37; NC38; NC70; l(2)NC37; l(2)NC38; l(2)NC70; lop1", "protein_names_uniprotkb": "Probable cytosolic Fe-S cluster assembly factor CG17683", "protein_names_refseq": "CG17683-PE; lethal (2) NC37; lethal (2) NC38; lethal (2) NC70; uncharacterized protein, isoform E", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17683)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5LJW9;Q5LJX0;Q7PLS3", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding", "go_cellular_component": "GO:0097361 cytosolic [4Fe-4S] assembly targeting complex;GO:0005829 cytosol", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0044572 [4Fe-4S] cluster assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8SYS7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8SYV9-1", "uniprot_id": [ { "id": "MTH14_DROME", "url": "https://www.uniprot.org/uniprot/Q8SYV9", "type": "external" } ], "mass": 60134.0, "length": 533, "protein_name": "Probable G protein-coupled receptor Mth-like 14", "gene_name": "mthl14", "organism": "Fruit fly", "refseq_name": "methuselah-like 14", "refseq_ac": [ { "id": "NP_728509", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_728509", "type": "external" } ], "gene_names_uniprotkb": "mthl14; CG32476", "gene_names_refseq": "BcDNA:RE31310; CG32476; Dmel\\CG32476; Mthl14; mthl14", "protein_names_uniprotkb": "Probable G protein-coupled receptor Mth-like 14; Protein methuselah-like 14", "protein_names_refseq": "CG32476-PA; methuselah-like 14; mthl14-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32476)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 9, "predicted_n_glycosites": 8, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8SYV9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8T062-1", "uniprot_id": [ { "id": "NEP4_DROME", "url": "https://www.uniprot.org/uniprot/Q8T062", "type": "external" } ], "mass": 119577.0, "length": 1040, "protein_name": "Neprilysin-4", "gene_name": "Nep4", "organism": "Fruit fly", "refseq_name": "neprilysin 4, isoform C", "refseq_ac": [ { "id": "NP_001262773", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262773", "type": "external" } ], "gene_names_uniprotkb": "Nep4; CG4058", "gene_names_refseq": "CG4058; DmeNEP4; Dmel\\CG4058; NEP4; Nep4A; Nep4; dNEP4; nep4B; nep4", "protein_names_uniprotkb": "Neprilysin-4; 3.4.24.11", "protein_names_refseq": "CG4058-PC; Nep4-PC; neprilysin 4, isoform C; neprilysin 4; neprilysin4", "tax_id": 7227, "disease": "X-linked hypophosphatemic rickets (Disease Ontology:DOID:0050445); Charcot-Marie-Tooth disease axonal type 2T (Disease Ontology:DOID:0110160); cerebellar ataxia type 43 (Disease Ontology:DOID:0111745); heart conduction disease (Disease Ontology:DOID:10273); Alzheimer's disease (Disease Ontology:DOID:10652); kidney failure (Disease Ontology:DOID:1074); otitis media (Disease Ontology:DOID:10754); hypertension (Disease Ontology:DOID:10763); membranous glomerulonephritis (Disease Ontology:DOID:10976); diarrhea (Disease Ontology:DOID:13250); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); periodontitis (Disease Ontology:DOID:824); cerebral amyloid angiopathy (Disease Ontology:DOID:9246)", "pathway": " (dme:Dmel_CG4058)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10731132;12537569;12537572;19880729;22583317;24395329;27629706;27919317", "class_list": "", "function": "Cleaves angiotensin-1 and tachykinin neuropeptide substance P (PubMed:19880729). Functions in maintaining muscle integrity, possibly independently of its endopeptidase activity (PubMed:22583317)., [UniProtKB, PubMed, PubMed]; Metalloendoprotease which cleaves peptides at the amino side of hydrophobic residues - such as the hormones Akh and Dh31, and the neuropeptides Allatostatins (AST1, AST2, AST3 and AST4), Crz, Drosulfakinins (DSK-I and DSK-II), Lk, sNPF and the tachykinin peptides TK-1, TK-2, TK-4 and TK-5 (PubMed:27919317). Functions in female fertility, memory formation and may also act in regulating insulin signaling and food intake (PubMed:24395329, PubMed:27629706). Likely to be involved in controlling feeding behavior and the expression of insulin-like peptides by cleaving various regulatory peptides that include certain Drosulfakinins, Allatostatins and tachykinin peptides (PubMed:27919317). Required in females for normal patterns of egg laying and hatching (PubMed:24395329). Required in the dorsal paired medial neurons for the proper formation of long-term (LTM) and middle-term memories (MTM) (PubMed:27629706). Also required in the mushroom body neurons where it functions redundantly with neprilysins Nep2 and Nep3, in normal LTM formation (PubMed:27629706)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q9I7I4", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8T062-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8T088-1", "uniprot_id": [ { "id": "WDR55_DROME", "url": "https://www.uniprot.org/uniprot/Q8T088", "type": "external" } ], "mass": 55322.0, "length": 498, "protein_name": "WD repeat-containing protein 55 homolog", "gene_name": "CG14722", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_650111", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650111", "type": "external" } ], "gene_names_uniprotkb": "CG14722", "gene_names_refseq": "CG14722; Dmel\\CG14722", "protein_names_uniprotkb": "WD repeat-containing protein 55 homolog", "protein_names_refseq": "CG14722-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14722)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VGI7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8T088-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8T390-1", "uniprot_id": [ { "id": "SH3G3_DROME", "url": "https://www.uniprot.org/uniprot/Q8T390", "type": "external" } ], "mass": 41409.0, "length": 369, "protein_name": "Endophilin-A", "gene_name": "EndoA", "organism": "Fruit fly", "refseq_name": "endophilin A, isoform C", "refseq_ac": [ { "id": "NP_001262717", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262717", "type": "external" } ], "gene_names_uniprotkb": "EndoA; CG14296; endo", "gene_names_refseq": "CG14296; D-endoA; D-endo; Dendo-A; Dmel\\CG14296; EndoA; Endo; endoA; endo", "protein_names_uniprotkb": "Endophilin-A; SH3 domain-containing GRB2-like protein", "protein_names_refseq": "CG14296-PC; EndoA-PC; Endophilin-A; endophilin A, isoform C; endophilin A; endophilinA; endophilin", "tax_id": 7227, "disease": "high grade glioma (Disease Ontology:DOID:3070); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (dme:Dmel_CG14296); (R-DME-177504); (R-DME-182971); (R-DME-432720); (R-DME-432722); (R-DME-437239); (R-DME-8856825); (R-DME-8856828)", "pathway_count": 8, "publication_count": 7, "publication_id_list": "10731132;11927550;11955450;12537572;17018572;18327897;22998870", "class_list": "", "function": "Required presynaptically at the neuromuscular junction. Implicated in synaptic vesicle endocytosis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q95V65;Q9VE25", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0016020 membrane;GO:0098793 presynapse;GO:0061174 type I terminal bouton", "go_biological_process": "GO:0097749 membrane tubulation;GO:0097753 membrane bending;GO:0000045 autophagosome assembly;GO:0006897 endocytosis;GO:0050803 regulation of synapse structure or activity", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8T390-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8T3Y0-1", "uniprot_id": [ { "id": "SINAL_DROME", "url": "https://www.uniprot.org/uniprot/Q8T3Y0", "type": "external" } ], "mass": 39645.0, "length": 351, "protein_name": "Probable E3 ubiquitin-protein ligase sinah", "gene_name": "sinah", "organism": "Fruit fly", "refseq_name": "sina homologue", "refseq_ac": [ { "id": "NP_648927", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648927", "type": "external" } ], "gene_names_uniprotkb": "sinah; CG13030", "gene_names_refseq": "CG13030; Dmel\\CG13030; SinaH; anon-WO0140519.228; sina-h; sinah", "protein_names_uniprotkb": "Probable E3 ubiquitin-protein ligase sinah; 2.3.2.27; RING-type E3 ubiquitin transferase sinah; Sina homolog", "protein_names_refseq": "CG13030-PC; Sina-Homologue; sina homologue; sinah-PC", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13030); (R-DME-983168)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;17561381;17962185", "class_list": "", "function": "E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. The adapter phyl is required to direct the degradation of the two isoforms of the transcriptional repressor Tramtrack (Ttk). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. A phyl-independent mechanism of degradation exists for isoform beta of ttk that involves motifs in the C-terminus of ttk., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VVB1", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0010498 proteasomal protein catabolic process;GO:0007423 sensory organ development;GO:0045676 regulation of R7 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8T3Y0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8WTC1-1", "uniprot_id": [ { "id": "RT15_DROME", "url": "https://www.uniprot.org/uniprot/Q8WTC1", "type": "external" } ], "mass": 33473.0, "length": 280, "protein_name": "Small ribosomal subunit protein uS15m", "gene_name": "bonsai", "organism": "Fruit fly", "refseq_name": "bonsai", "refseq_ac": [ { "id": "NP_611691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611691", "type": "external" } ], "gene_names_uniprotkb": "bonsai; CG4207; mRpS15", "gene_names_refseq": "CG4207; DmMRPS15; Dmel\\CG4207; MRP-S15; bonsai; mRpS15", "protein_names_uniprotkb": "Small ribosomal subunit protein uS15m; 28S ribosomal protein S15, mitochondrial; DmMRPS15; MRP-S15; Protein bonsai; S15mt", "protein_names_refseq": "CG4207-PA; bonsai-PA; bonsai", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4207); (R-DME-5389840); (R-DME-5419276); (R-DME-9937383)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "10225996;10731132;12537569;12537572;14651932", "class_list": "", "function": "Essential for gut mitochondrial activity. Might be involved in tissue specific growth factor production., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W231", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion", "go_biological_process": "GO:0040008 regulation of growth;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8WTC1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q94517-1", "uniprot_id": [ { "id": "HDAC1_DROME", "url": "https://www.uniprot.org/uniprot/Q94517", "type": "external" } ], "mass": 58331.0, "length": 521, "protein_name": "Histone deacetylase HDAC1", "gene_name": "HDAC1", "organism": "Fruit fly", "refseq_name": "histone deacetylase 1", "refseq_ac": [ { "id": "NP_647918", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647918", "type": "external" } ], "gene_names_uniprotkb": "HDAC1; CG7471; Rpd3", "gene_names_refseq": "CG7471; DHDAC1; DRpd3; DmHDAC1; DmRpd3; Dmel\\CG7471; E(var)3-64BC; HDAC-1; HDAC1; HDAC; Hdac1; Hdac; RPD3; Rpd3/HDAC; Rpd3; Su(var)3-26; Su(var)3-64B; Su(var)326; Su(var)328; dHDAC-1; dHDAC1; dRPD3; dRpd3; dmHDA401; drpd3; hdac1; l(3)04556; l(3)64Cc; rpd3; rpd[3]", "protein_names_uniprotkb": "Histone deacetylase HDAC1; 3.5.1.98; HD", "protein_names_refseq": "CG7471-PA; HDAC1-PA; Rpd3 histone deacetylase; histone Deacetylase-1; histone deacetylase 1 (HDAC1); histone deacetylase 1; histone deacetylase RPD3; histone deacetylase; reduced potassium dependency 3; suppressor of variegation 326", "tax_id": 7227, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); stroke (Disease Ontology:DOID:0051061); prostate carcinoma (Disease Ontology:DOID:10286); stomach cancer (Disease Ontology:DOID:10534); alcohol use disorder (Disease Ontology:DOID:1574); glaucoma (Disease Ontology:DOID:1686); anxiety disorder (Disease Ontology:DOID:2030); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); temporal lobe epilepsy (Disease Ontology:DOID:3328); breast carcinoma (Disease Ontology:DOID:3459); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); bronchitis (Disease Ontology:DOID:6132); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); Peyronie's disease (Disease Ontology:DOID:8616); prostate carcinoma in situ (Disease Ontology:DOID:8634); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); colorectal cancer (Disease Ontology:DOID:9256); pulmonary emphysema (Disease Ontology:DOID:9675); type 1 diabetes mellitus (Disease Ontology:DOID:9744); alopecia areata (Disease Ontology:DOID:986); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (dme:Dmel_CG7471); (R-DME-1538133); (R-DME-201722); (R-DME-209394); (R-DME-3214815); (R-DME-350054); (R-DME-3769402); (R-DME-6804758); (R-DME-8936459); (R-DME-8943724); (R-DME-9018519); (R-DME-9701898); (R-DME-9764725); (R-DME-9824594); (R-DME-9825892); (R-DME-983231); (R-DME-9937850); (R-DME-9940951)", "pathway_count": 18, "publication_count": 22, "publication_id_list": "10409696;10655219;10731132;11269501;11571273;12408863;12533794;12537569;12537572;12697833;12732719;15306652;15545624;15640802;17803358;18250149;18327897;23177352;26389589;26399365;28245922;8955276", "class_list": "", "function": "Catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:11571273, PubMed:12408863, PubMed:28245922). Histone deacetylation may constitute a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:11571273, PubMed:15306652, PubMed:15545624, PubMed:8955276). For instance, deacetylation of histone H3 may be a prerequisite for the subsequent recruitment of the histone methyltransferase Su(var)3-9 to histones (PubMed:11571273). Involved in position-effect variegation (PEV) (PubMed:11571273). In the larval brain, part of a regulatory network including the transcriptional repressors klu, dpn and E(spl)mgamma-HLH which is required for type II neuroblast self-renewal and for maintaining erm in an inactive state in intermediate neural progenitors (INP) (PubMed:28245922)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 25, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O17429;O77213;Q9VZA1", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.14.99.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.66", "type": "external" } ], "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0004407 histone deacetylase activity;GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism;GO:0140297 DNA-binding transcription factor binding;GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0017053 transcription repressor complex;GO:0000785 chromatin", "go_biological_process": "GO:2001229 negative regulation of response to gamma radiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q94517-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q94522-1", "uniprot_id": [ { "id": "SUCA_DROME", "url": "https://www.uniprot.org/uniprot/Q94522", "type": "external" } ], "mass": 34389.0, "length": 328, "protein_name": "Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial", "gene_name": "Scsalpha1", "organism": "Fruit fly", "refseq_name": "Succinyl-coenzyme A synthetase alpha subunit 1, isoform B", "refseq_ac": [ { "id": "NP_001189044", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001189044", "type": "external" } ], "gene_names_uniprotkb": "Scsalpha1; CG1065; Scsalpha", "gene_names_refseq": "CG1065; Dmel\\CG1065; Scs-alpha; Scsalpha1; Scsalpha; Scsa; scsalpha", "protein_names_uniprotkb": "Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; 6.2.1.4; 6.2.1.5; SCS-alpha; Succinyl-CoA synthetase subunit alpha; Succinyl-coenzyme A synthetase alpha subunit 1", "protein_names_refseq": "CG1065-PB; Scsalpha1-PB; Succinyl-coenzyme A synthetase alpha subunit 1, isoform B; succinyl CoA synthetase; succinyl coenzyme A synthatase, alpha subunit; succinyl coenzyme A synthetase alpha subunit; succinyl-CoA synthetase alpha-subunit", "tax_id": 7227, "disease": "mitochondrial DNA depletion syndrome 9 (Disease Ontology:DOID:0080128)", "pathway": " (dme:Dmel_CG1065); (R-DME-71403)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10071211;10731132;12537569;12537572;28017724", "class_list": "", "function": "Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits., [UniProtKB, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "M9MRQ9;Q8SXM7;Q9VZM4", "ec_number_list": [ { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "6.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.5", "type": "external" } ], "go_molecular_function": "GO:0000166 nucleotide binding;GO:0004775 succinate-CoA ligase (ADP-forming) activity;GO:0004776 succinate-CoA ligase (GDP-forming) activity;GO:0004774 succinate-CoA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0045244 succinate-CoA ligase complex (GDP-forming);GO:0009361 succinate-CoA ligase complex (ADP-forming)", "go_biological_process": "GO:0006099 tricarboxylic acid cycle", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q94522-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q94523-1", "uniprot_id": [ { "id": "SDHA_DROME", "url": "https://www.uniprot.org/uniprot/Q94523", "type": "external" } ], "mass": 72343.0, "length": 661, "protein_name": "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial", "gene_name": "SdhA", "organism": "Fruit fly", "refseq_name": "succinate dehydrogenase, subunit A (flavoprotein), isoform A", "refseq_ac": [ { "id": "NP_477210", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477210", "type": "external" } ], "gene_names_uniprotkb": "SdhA; CG17246; Scs-fp", "gene_names_refseq": "2R1; CG17246; DHSA; Dmel\\CG17246; SDH; Scs-fp; Sdh A; SdhA; Sdha; Sdh; dSDHA; scs-fp; sdhA; sdh", "protein_names_uniprotkb": "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; 1.3.5.1; FP; Flavoprotein subunit of complex II; Succinyl coenzyme A synthetase flavoprotein subunit", "protein_names_refseq": "CG17246-PA; COMPLEX II: flavoprotein subunit; SUCCINYL COENZIME A SYNTHETASE FLAVOPROTEIN SUBUNIT; SdhA-PA; succinate dehydrogenase A; succinate dehydrogenase [ubiquinone] flavoprotein subunit; succinate dehydrogenase flavoprotein subunit; succinate dehydrogenase flavoprotein; succinate dehydrogenase, subunit A (flavoprotein), isoform A; succinyl CoA synthetase flavoprotein subunit of complex II; succinyl coenzyme A synthetase flavoprotein subunit", "tax_id": 7227, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); pheochromocytoma (Disease Ontology:DOID:0050771); paraganglioma (Disease Ontology:DOID:0050773); mitochondrial complex II deficiency (Disease Ontology:DOID:0060537); pheochromocytoma/paraganglioma syndrome 5 (Disease Ontology:DOID:0061220); dilated cardiomyopathy 1GG (Disease Ontology:DOID:0110435); leukodystrophy (Disease Ontology:DOID:10579); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); Leigh disease (Disease Ontology:DOID:3652); pituitary adenoma (Disease Ontology:DOID:3829); lung non-small cell carcinoma (Disease Ontology:DOID:3908); gastrointestinal stromal tumor (Disease Ontology:DOID:9253)", "pathway": " (dme:Dmel_CG17246); (R-DME-71403); (R-DME-9854311)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10071211;10731132;12537569;12537572;15693940;18599508", "class_list": "", "function": "Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Maintaining electron transport chain function is required to prevent neurodegenerative changes seen in both early- and late-onset disorders., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4UZP5;C7LA77;Q0E918;Q9I7G3", "ec_number_list": [ { "id": "1.3.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.5.1", "type": "external" }, { "id": "1.3.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.-.-", "type": "external" } ], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0050660 flavin adenine dinucleotide binding;GO:0008177 succinate dehydrogenase (quinone) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045273 respiratory chain complex II (succinate dehydrogenase)", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0022900 electron transport chain;GO:0022904 respiratory electron transport chain;GO:0006105 succinate metabolic process;GO:0006121 mitochondrial electron transport, succinate to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q94523-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q94527-1", "uniprot_id": [ { "id": "NFKB1_DROME", "url": "https://www.uniprot.org/uniprot/Q94527", "type": "external" } ], "mass": 109775.0, "length": 971, "protein_name": "Nuclear factor NF-kappa-B p110 subunit", "gene_name": "Rel", "organism": "Fruit fly", "refseq_name": "relish, isoform A", "refseq_ac": [ { "id": "NP_477094", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477094", "type": "external" } ], "gene_names_uniprotkb": "Rel; CG11992", "gene_names_refseq": "CG11992; Dmel\\CG11992; NF-KB; NF-kappaBeta; NF-kappaB; NFkappaB; RELI; REL; Rel-p110; Rel/NF-kappaB; Rel1; Rel49; RelA; Rel; ird4; ird; l(3)neo36; relish; rel", "protein_names_uniprotkb": "Nuclear factor NF-kappa-B p110 subunit; Rel-p110; Rel-p49; Rel-p68; Relish protein", "protein_names_refseq": "CG11992-PA; Rel-PA; immune response deficient 4; nuclear Factor-kappa-B p110; nuclear factor NF-kappa-B p110 subunit; relish, isoform A; relish", "tax_id": 7227, "disease": "opportunistic bacterial infectious disease (Disease Ontology:DOID:0050340); Parkinsonism (Disease Ontology:DOID:0080855); common variable immunodeficiency 10 (Disease Ontology:DOID:0081152); common variable immunodeficiency 12 (Disease Ontology:DOID:0081154); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); common variable immunodeficiency (Disease Ontology:DOID:12177); neurodegenerative disease (Disease Ontology:DOID:1289); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); melanoma (Disease Ontology:DOID:1909); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); lung non-small cell carcinoma (Disease Ontology:DOID:3908); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dme:Dmel_CG11992); (R-DME-1169091); (R-DME-1810476); (R-DME-202424); (R-DME-209394); (R-DME-209560); (R-DME-214399); (R-DME-214411); (R-DME-214416); (R-DME-2871837); (R-DME-3134963); (R-DME-445989); (R-DME-5607761); (R-DME-5607764); (R-DME-5621575); (R-DME-5676590); (R-DME-6798695); (R-DME-9020702); (R-DME-933542); (R-DME-9860927); (R-DME-9958825)", "pathway_count": 21, "publication_count": 26, "publication_id_list": "10409696;10619029;10731132;10757765;11018014;11269501;11269502;11872802;12537569;12537572;12732719;15640802;17803358;18000549;18327897;22022271;24947515;25180232;25477468;29924997;29934091;30119996;33262294;34261127;34261128;8816802", "class_list": "", "function": "Transcription factor that plays a key role in the humoral immune response as part of the peptidoglycan recognition protein (IMD) signaling pathway (PubMed:10619029, PubMed:11269501, PubMed:11872802, PubMed:22022271, PubMed:29924997, PubMed:8816802). Rel-p68 subunit translocates to the nucleus where it binds to the promoter of the Cecropin A1 gene and probably other antimicrobial peptide genes (PubMed:11269501, PubMed:29924997). I-kappa-B kinase complex (IKKbeta and key) and PGRP-LC are essential signaling components in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation for NF-kappa-B (rel) activation (PubMed:11018014, PubMed:11872802). Part of a Toll-related receptor pathway that functions in the apoptosis of unfit cells during cell competition (PubMed:25477468). Also part of some antiviral immunity: activated downstream of Sting signaling, which detects double-stranded RNA (dsRNA) from viruses, and promotes expression of antiviral effector genes (PubMed:29934091, PubMed:30119996, PubMed:33262294, PubMed:34261127, PubMed:34261128). May be part of a NF-kappa-B and Tollo signaling cascade that regulates development of the peripheral nervous system (PubMed:18000549). Possibly post-transcriptionally regulates the neuron-specific genes sc and ase, by promoting the rapid turnover of their transcripts in the wing imaginal disk (PubMed:18000549)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V2K3;Q9U435;Q9U436;Q9U437;Q9U438;Q9U439;Q9U440;Q9U6H3;Q9U6H4;Q9U6H5;Q9VHI0", "ec_number_list": [], "go_molecular_function": "GO:0030547 signaling receptor inhibitor activity;GO:0042802 identical protein binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000791 euchromatin", "go_biological_process": "GO:2000647 negative regulation of stem cell proliferation;GO:0006351 DNA-templated transcription;GO:0006955 immune response;GO:0010628 positive regulation of gene expression;GO:0045429 positive regulation of nitric oxide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q94527-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q94890-1", "uniprot_id": [ { "id": "H15_DROME", "url": "https://www.uniprot.org/uniprot/Q94890", "type": "external" } ], "mass": 72370.0, "length": 660, "protein_name": "T-box protein H15", "gene_name": "H15", "organism": "Fruit fly", "refseq_name": "H15, isoform A", "refseq_ac": [ { "id": "NP_608926", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608926", "type": "external" } ], "gene_names_uniprotkb": "H15; CG6604; Dm-H15; Dmel\\CG6604; Dmel_CG6604; Nmr-1; Nmr1; Nmr; Tbx20; dm-H15; nmr1; nmr[H15]; nmr", "gene_names_refseq": "CG6604; Dm-H15; Dmel\\CG6604; H15; Nmr-1; Nmr1; Nmr; Tbx20; dm-H15; nmr1; nmr[H15]; nmr", "protein_names_uniprotkb": "T-box protein H15", "protein_names_refseq": "CG6604-PA; H15, isoform A; H15-PA; neuromancer 1; neuromancer 2; neuromancer-1; neuromancer1", "tax_id": 7227, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); atrial heart septal defect 4 (Disease Ontology:DOID:0110109); dilated cardiomyopathy (Disease Ontology:DOID:12930); ventricular septal defect (Disease Ontology:DOID:1657); congenital heart disease (Disease Ontology:DOID:1682); atrial heart septal defect (Disease Ontology:DOID:1882); tetralogy of Fallot (Disease Ontology:DOID:6419)", "pathway": " (dme:Dmel_CG6604)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8703069", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9VMR3", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0001708 cell fate specification;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q94890-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q95028-1", "uniprot_id": [ { "id": "LDH_DROME", "url": "https://www.uniprot.org/uniprot/Q95028", "type": "external" } ], "mass": 35537.0, "length": 332, "protein_name": "L-lactate dehydrogenase", "gene_name": "Ldh", "organism": "Fruit fly", "refseq_name": "lactate dehydrogenase, isoform B", "refseq_ac": [ { "id": "NP_001261474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261474", "type": "external" } ], "gene_names_uniprotkb": "Ldh; CG10160; Imp-L3; ImpL3", "gene_names_refseq": "CG10160; Dmel\\CG10160; IMP-L3; IMPL3; Imp-L3; ImpL3; Impl 3; Impl3; LDH; Ldh; Ld; dLDH; dLdha; dLdh; dmLDH; impL3; impl3; ldh; lincRNA.S4223", "protein_names_uniprotkb": "L-lactate dehydrogenase; 1.1.1.27", "protein_names_refseq": "CG10160-PB; Ecdysone-induced gene L3; Ecdysone-inducible gene L3; Ldh-PB; lactate dehydrogenase B; lactate dehydrogenase, isoform B; lactate/malate dehydrogenease; lactic DH", "tax_id": 7227, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); hypertension (Disease Ontology:DOID:10763); hyperglycemia (Disease Ontology:DOID:4195)", "pathway": " (dme:Dmel_CG10160); (R-DME-70268); (R-DME-9861718)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10731132;12537572;9094207", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9VRW6", "ec_number_list": [ { "id": "1.1.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.27", "type": "external" } ], "go_molecular_function": "GO:0004459 L-lactate dehydrogenase (NAD+) activity;GO:0047545 (S)-2-hydroxyglutarate dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0042866 pyruvate biosynthetic process;GO:0019674 NAD+ metabolic process;GO:0006096 glycolytic process;GO:0019244 lactate biosynthetic process from pyruvate;GO:0006089 lactate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q95028-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q95083-1", "uniprot_id": [ { "id": "PSA5_DROME", "url": "https://www.uniprot.org/uniprot/Q95083", "type": "external" } ], "mass": 26884.0, "length": 244, "protein_name": "Proteasome subunit alpha type-5", "gene_name": "Prosalpha5", "organism": "Fruit fly", "refseq_name": "proteasome alpha5 subunit, isoform B", "refseq_ac": [ { "id": "NP_477202", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477202", "type": "external" } ], "gene_names_uniprotkb": "Prosalpha5; CG10938; ProsMA5", "gene_names_refseq": "154644_at; Alpha-5; CG10938; Dmel\\CG10938; PRCZ; PSA5_DROME; PSMA5; ProsMA5; Prosalpha5; alpha-5; alpha5_dm; alpha5; prosMA5; prosalpha5", "protein_names_uniprotkb": "Proteasome subunit alpha type-5", "protein_names_refseq": "20s proteasome; CG10938-PB; Prosalpha5-PB; alpha-subunit of 20S proteasome; alpha5; proteasome alpha subunit; proteasome alpha5 subunit, isoform B", "tax_id": 7227, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (dme:Dmel_CG10938); (R-DME-1169091); (R-DME-1234176); (R-DME-1236974); (R-DME-1236978); (R-DME-174084); (R-DME-174154); (R-DME-174178); (R-DME-174184); (R-DME-187577); (R-DME-195253); (R-DME-202424); (R-DME-209360); (R-DME-209406); (R-DME-209461); (R-DME-216167); (R-DME-2467813); (R-DME-2871837); (R-DME-350562); (R-DME-382556); (R-DME-432395); (R-DME-432524); (R-DME-432626); (R-DME-450408); (R-DME-4608870); (R-DME-4641257); (R-DME-4641258); (R-DME-5358346); (R-DME-538864); (R-DME-5607761); (R-DME-5607764); (R-DME-5610780); (R-DME-5610785); (R-DME-5632684); (R-DME-5658442); (R-DME-5676590); (R-DME-5689603); (R-DME-5689880); (R-DME-6798695); (R-DME-68867); (R-DME-68949); (R-DME-69017); (R-DME-69601); (R-DME-75815); (R-DME-8854050); (R-DME-8939236); (R-DME-8939902); (R-DME-8941858); (R-DME-8948751); (R-DME-8951664); (R-DME-9020702); (R-DME-9755511); (R-DME-9762114); (R-DME-983168); (R-DME-9907900); (R-DME-9912633); (R-DME-9929491); (R-DME-9932298); (R-DME-9954709)", "pathway_count": 59, "publication_count": 36, "publication_id_list": "10102270;10417378;10458606;10481010;10731132;11585911;12231619;12432393;12442174;12537569;12537572;12973300;15178801;15258584;15331761;16139204;16299518;16326393;16386907;16543224;16603629;16651542;16740475;16794082;17102630;17925225;18519643;18593878;19185492;7705656;8948598;9025065;9215627;9409776;9553105;9990853", "class_list": "", "function": "The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0E942;Q9V809", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000502 proteasome complex;GO:0019773 proteasome core complex, alpha-subunit complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0008340 determination of adult lifespan", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "Q95083-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q95RJ9-1", "uniprot_id": [ { "id": "EBI_DROME", "url": "https://www.uniprot.org/uniprot/Q95RJ9", "type": "external" } ], "mass": 72387.0, "length": 700, "protein_name": "F-box-like/WD repeat-containing protein ebi", "gene_name": "ebi", "organism": "Fruit fly", "refseq_name": "ebi", "refseq_ac": [ { "id": "NP_477329", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477329", "type": "external" } ], "gene_names_uniprotkb": "ebi; CG4063", "gene_names_refseq": "CG4063; Dmel\\CG4063; E-2f; E-2g; Ebi; FBXW4; Tb11; Tbl1; ebi; l(2)k16213", "protein_names_uniprotkb": "F-box-like/WD repeat-containing protein ebi", "protein_names_refseq": "CG4063-PA; beta transducin-like 1 protein; ebi-PA; ebi; enhancer on chromosome 2-complementation group 2g", "tax_id": 7227, "disease": "sensory system disease (Disease Ontology:DOID:0050155); autosomal dominant intellectual developmental disorder 41 (Disease Ontology:DOID:0070071); Pierpont syndrome (Disease Ontology:DOID:0081362); Y-linked deafness 2 (Disease Ontology:DOID:0111758); congenital nongoitrous hypothyroidism 8 (Disease Ontology:DOID:0111837)", "pathway": " (dme:Dmel_CG4063); (R-DME-350054); (R-DME-400206); (R-DME-9029569); (R-DME-9707564); (R-DME-9841922)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "10215623;10731132;11032805;12230979;12537569;12537572", "class_list": "", "function": "F-box-like component of E3 ubiquitin ligase complexes; involved in R7 photoreceptor cell differentiation, cone cell development and neuronal cell cycle control. E3 ubiquitin ligase complexes mediate ubiquitination and subsequent proteasomal degradation of target proteins. Required for specification of R7 photoreceptor cell fate in the eye by participating in the ubiquitination and subsequent proteasomal degradation of Tramtrack (ttk), a general inhibitor of photoreceptor differentiation. Required to block the S phase entry in the peripheral nervous system and central nervous system in a process that does not involve the degradation of ttk. Involved in cone cell development by preventing the transcriptional repression mediated by Su(H) on Dl, probably by participating in a E3 complex that contains sno and mediates the ubiquitination and subsequent proteasomal degradation of some component of the Su(H) repressor complex., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9XZK1", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003714 transcription corepressor activity;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0017053 transcription repressor complex;GO:0000118 histone deacetylase complex;GO:0005700 polytene chromosome", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006979 response to oxidative stress;GO:0070050 neuron cellular homeostasis;GO:0045892 negative regulation of DNA-templated transcription;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q95RJ9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q95SS8-1", "uniprot_id": [ { "id": "TMM70_DROME", "url": "https://www.uniprot.org/uniprot/Q95SS8", "type": "external" } ], "mass": 26666.0, "length": 236, "protein_name": "Transmembrane protein 70 homolog, mitochondrial", "gene_name": "Tmem70", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_648144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648144", "type": "external" } ], "gene_names_uniprotkb": "Tmem70; CG7506", "gene_names_refseq": "CG7506; Dmel\\CG7506; dTMEM70", "protein_names_uniprotkb": "Transmembrane protein 70 homolog, mitochondrial", "protein_names_refseq": "CG7506-PA; uncharacterized protein", "tax_id": 7227, "disease": "mitochondrial complex V (ATP synthase) deficiency nuclear type 2 (Disease Ontology:DOID:0060331)", "pathway": " (dme:Dmel_CG7506)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;34386730", "class_list": "", "function": "Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) (By similarity). Also binds the mitochondrial proton-transporting ATP synthase complex I and may play a role in the stability of its membrane-bound subassemblies (Probable)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VS96", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q95SS8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q95TN1-1", "uniprot_id": [ { "id": "TPC13_DROME", "url": "https://www.uniprot.org/uniprot/Q95TN1", "type": "external" } ], "mass": 48683.0, "length": 438, "protein_name": "Probable trafficking protein particle complex subunit 13 homolog", "gene_name": "CG4953", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_609365", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609365", "type": "external" } ], "gene_names_uniprotkb": "CG4953", "gene_names_refseq": "CG4953; Dmel\\CG4953; TRAPPC13", "protein_names_uniprotkb": "Probable trafficking protein particle complex subunit 13 homolog", "protein_names_refseq": "CG4953-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4953); (R-DME-8876198)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VL12", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:1990072 TRAPPIII protein complex", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0048193 Golgi vesicle transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q95TN1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9BIS2-1", "uniprot_id": [ { "id": "HSP73_DROME", "url": "https://www.uniprot.org/uniprot/Q9BIS2", "type": "external" } ], "mass": 70195.0, "length": 641, "protein_name": "Major heat shock 70 kDa protein Bb", "gene_name": "Hsp70Bb", "organism": "Fruit fly", "refseq_name": "heat shock protein 70 Bb", "refseq_ac": [ { "id": "NP_524927", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524927", "type": "external" } ], "gene_names_uniprotkb": "Hsp70Bb; CG31359", "gene_names_refseq": "Bb; CG31359; DMHSP7D1; Dm-hsp70; Dmel\\CG31359; HSP70Bb; HSP70cA4; HSP70; Hsp 70; Hsp-70; Hsp70(87C); Hsp70A7d; Hsp70Bbc; Hsp70Bb; Hsp70Bc; Hsp70B; Hsp70bb; Hsp70; dHsp70; dhsp70; hsp-70; hsp70 87C; hsp70Bb; hsp70B; hsp70", "protein_names_uniprotkb": "Major heat shock 70 kDa protein Bb; HSP70-87C1; Heat shock protein 70Bb", "protein_names_refseq": "70 kDa heat shock protein, cytosolic A 4; 87C locus; CG31359-PA; Heat-shock-protein-70Bb; Hsp70Bb-PA; heat shock protein 70 Bb; heat shock protein 70; heat-shock protein 70; protein 70", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31359); (dme:Dmel_CG6489)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10731132;11493638;11965431;12361573;12537572;15574805;18344983;6777045", "class_list": "", "function": "Stress-response chaperone protein that prevents toxic aggregation of proteins., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B0BNN7;P02824;Q53XF0;Q5I7H2;Q5I7H4;Q5I7H6;Q5I7H8;Q5I7I3;Q5I7I6;Q5I7I8;Q9BIS1;Q9I7J6", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0001666 response to hypoxia;GO:0009408 response to heat;GO:0042026 protein refolding;GO:0006986 response to unfolded protein;GO:0035080 heat shock-mediated polytene chromosome puffing", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9BIS2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9GQQ0-1", "uniprot_id": [ { "id": "SPIN_DROME", "url": "https://www.uniprot.org/uniprot/Q9GQQ0", "type": "external" } ], "mass": 65820.0, "length": 605, "protein_name": "Protein spinster", "gene_name": "spin", "organism": "Fruit fly", "refseq_name": "spinster, isoform D", "refseq_ac": [ { "id": "NP_524823", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524823", "type": "external" } ], "gene_names_uniprotkb": "spin; CG8428; bnch", "gene_names_refseq": "25/11; CG8428; Dmel\\CG8428; Spin; bnch; l(2)10403; l(2)W5; l(2)k02511; l(2)k09905; l(2R)W5; spin", "protein_names_uniprotkb": "Protein spinster; Protein benchwarmer; Protein diphthong", "protein_names_refseq": "CG8428-PD; Spinster/Benchwarmer; benchwarmer; diphthong; lethal (2) W5; spin-PD; spinster, isoform D; spinster", "tax_id": 7227, "disease": "autosomal recessive nonsyndromic deafness 115 (Disease Ontology:DOID:0111643); neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503); sphingolipidosis (Disease Ontology:DOID:1927)", "pathway": " (dme:Dmel_CG8428); (R-DME-1660661)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10731132;11340170;12408844;12537569;12537572;15998804", "class_list": "", "function": "Probable sphingolipid transporter that plays a central role in endosomes and/or lysosomes storage. Involved in TGF-beta-mediated synaptic growth regulation both pre- and postsynaptically via its function in endosomal storage regulation. Also required during oogenesis by regulating yolk spheres storage., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A1ZAA4;Q960X6;Q9GQP9;Q9GQQ1;Q9GQQ2;Q9GQQ3;Q9V7J3", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0031982 vesicle;GO:0098793 presynapse", "go_biological_process": "GO:0006869 lipid transport;GO:0006897 endocytosis;GO:0051124 synaptic assembly at neuromuscular junction;GO:0055085 transmembrane transport;GO:0007040 lysosome organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9GQQ0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9I7H9-1", "uniprot_id": [ { "id": "OGFD1_DROME", "url": "https://www.uniprot.org/uniprot/Q9I7H9", "type": "external" } ], "mass": 61193.0, "length": 536, "protein_name": "Prolyl 3-hydroxylase sudestada1", "gene_name": "sud1", "organism": "Fruit fly", "refseq_name": "sudestada1", "refseq_ac": [ { "id": "NP_733061", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_733061", "type": "external" } ], "gene_names_uniprotkb": "sud1; CG18761; CG31120; CG44254", "gene_names_refseq": "CG18761; CG31120; CG44254; Dmel\\CG44254; sud1", "protein_names_uniprotkb": "Prolyl 3-hydroxylase sudestada1; 1.14.11.-; 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 homolog; uS12 prolyl 3-hydroxylase", "protein_names_refseq": "CG44254-PA; sud1-PA; sudestada1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG44254); (R-DME-9629569)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;24550463", "class_list": "", "function": "Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RpS23), thereby regulating protein translation termination efficiency., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0031418 L-ascorbic acid binding;GO:0031543 peptidyl-proline dioxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006449 regulation of translational termination;GO:0006417 regulation of translation;GO:0018126 protein hydroxylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9I7H9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9I7M2-1", "uniprot_id": [ { "id": "GTPBA_DROME", "url": "https://www.uniprot.org/uniprot/Q9I7M2", "type": "external" } ], "mass": 41789.0, "length": 383, "protein_name": "GTP-binding protein 10 homolog", "gene_name": "CG10628", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_609999", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609999", "type": "external" } ], "gene_names_uniprotkb": "CG10628", "gene_names_refseq": "CG10628; Dmel\\CG10628", "protein_names_uniprotkb": "GTP-binding protein 10 homolog", "protein_names_refseq": "CG10628-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10628)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "May be involved in the ribosome maturation process., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SZE0", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019843 rRNA binding;GO:0140978 mitochondrial large ribosomal subunit binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:1902775 mitochondrial large ribosomal subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9I7M2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9I7S8-1", "uniprot_id": [ { "id": "PUR6_DROME", "url": "https://www.uniprot.org/uniprot/Q9I7S8", "type": "external" } ], "mass": 47281.0, "length": 429, "protein_name": "Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase", "gene_name": "Paics", "organism": "Fruit fly", "refseq_name": "PAICS bifunctional enzyme, isoform A", "refseq_ac": [ { "id": "NP_572826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572826", "type": "external" } ], "gene_names_uniprotkb": "Paics; CG3989; ade5", "gene_names_refseq": "AIRc-SAICARs; Ade5; CG3989; Dmel\\CG3989; Paics; ade5", "protein_names_uniprotkb": "Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase; AIR carboxylase; AIRC; PAICS; Protein adenosine-5; SAICAR synthetase", "protein_names_refseq": "AIR-carboxylase-SAICAR synthetase; CG3989-PA; PAICS bifunctional enzyme, isoform A; Paics-PA; ade5", "tax_id": 7227, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dme:Dmel_CG3989); (R-DME-73817)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;10757766;12537569;12537572;15952742", "class_list": "", "function": "Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9TVK1", "ec_number_list": [ { "id": "4.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.21", "type": "external" }, { "id": "6.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.6", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity;GO:0004638 phosphoribosylaminoimidazole carboxylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006189 'de novo' IMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9I7S8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9I7W5-1", "uniprot_id": [ { "id": "SAS10_DROME", "url": "https://www.uniprot.org/uniprot/Q9I7W5", "type": "external" } ], "mass": 49454.0, "length": 428, "protein_name": "Something about silencing protein 10", "gene_name": "Sas10", "organism": "Fruit fly", "refseq_name": "something about silencing 10", "refseq_ac": [ { "id": "NP_572215", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572215", "type": "external" } ], "gene_names_uniprotkb": "Sas10; CG4202", "gene_names_refseq": "CG4202; Dmel\\CG4202; Sas10; dSAS10; l(1)G0106; sas-10; sas10", "protein_names_uniprotkb": "Something about silencing protein 10", "protein_names_refseq": "CG4202-PA; Sas10-PA; something about silencing 10 ortholog; something about silencing 10", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4202); (R-DME-6791226)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;12756328;18327897", "class_list": "", "function": "Essential for gene silencing: has a role in the structure of silenced chromatin. May be involved in gene regulation during development. Binds RNA., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q961T6", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0032040 small-subunit processome", "go_biological_process": "GO:0006325 chromatin organization;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9I7W5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9I816-1", "uniprot_id": [ { "id": "OR19A_DROME", "url": "https://www.uniprot.org/uniprot/Q9I816", "type": "external" } ], "mass": 44228.0, "length": 387, "protein_name": "Odorant receptor 19a", "gene_name": "Or19a", "organism": "Fruit fly", "refseq_name": "odorant receptor 19a", "refseq_ac": [ { "id": "NP_525013", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_525013", "type": "external" } ], "gene_names_uniprotkb": "Or19a; CG18859", "gene_names_refseq": "19A.1; 19a; CG18859; DOR37; DmOr19a; Dmel\\CG18859; OR19a; Or19a-1; Or19a", "protein_names_uniprotkb": "Odorant receptor 19a", "protein_names_refseq": "CG18859-PB; Or19a-PB; odorant receptor 19a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18859)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;10943836;12537572;16615896;24316206", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the preference for citrus fruits for oviposition, especially through the response to valencene, the primary ligand of Or19a. Larvae growing on citrus fruits suffer a reduced risk of parasitism since endoparasitoid wasps that parasitize larvae are strongly repelled by the smell of citrus, as well as by valencene., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9I816-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9NHB0-1", "uniprot_id": [ { "id": "GNBP1_DROME", "url": "https://www.uniprot.org/uniprot/Q9NHB0", "type": "external" } ], "mass": 55314.0, "length": 492, "protein_name": "Gram-negative bacteria-binding protein 1", "gene_name": "GNBP1", "organism": "Fruit fly", "refseq_name": "Gram-negative bacteria binding protein 1", "refseq_ac": [ { "id": "NP_524142", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524142", "type": "external" } ], "gene_names_uniprotkb": "GNBP1; CG6895", "gene_names_refseq": "CG6895; DGNBP-1; DGNBP1; Dmel\\CG6895; GNBP 1; GNBP-1; GNBP1; GNBP", "protein_names_uniprotkb": "Gram-negative bacteria-binding protein 1", "protein_names_refseq": "CG6895-PA; GNBP1-PA; Gram-negative bacteria binding protein 1; glucan-binding protein 1; gram-negative binding protein 1; osiris", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6895)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;10827089;12537572;16399077;17103056", "class_list": "", "function": "Plays a key role in innate immunity by acting as a pattern recognition receptor for beta-1,3-glucan from fungi and lipopolysaccharide from Gram-negative bacteria (PubMed:10827089). Upon recognition of invading microorganism-derived products, acts upstream of protease spz processing enzyme SPE to activate the Toll pathway and to induce the expression of antimicrobial peptides drosomycin, cecropin and attacin (PubMed:10827089, PubMed:16399077)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0ZX68;Q9VVR5", "ec_number_list": [], "go_molecular_function": "GO:0042834 peptidoglycan binding;GO:0001530 lipopolysaccharide binding;GO:0001872 (1->3)-beta-D-glucan binding;GO:0038187 pattern recognition receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0002221 pattern recognition receptor signaling pathway;GO:0006955 immune response;GO:0045087 innate immune response;GO:0050830 defense response to Gram-positive bacterium;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9NHB0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9NHD5-1", "uniprot_id": [ { "id": "SAN_DROME", "url": "https://www.uniprot.org/uniprot/Q9NHD5", "type": "external" } ], "mass": 20994.0, "length": 184, "protein_name": "Probable N-acetyltransferase san", "gene_name": "san", "organism": "Fruit fly", "refseq_name": "separation anxiety", "refseq_ac": [ { "id": "NP_524779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524779", "type": "external" } ], "gene_names_uniprotkb": "san; CG12352; span", "gene_names_refseq": "CG12352; DmAAF34715; Dmel\\CG12352; NAA50; Naa50; San; atado; dNaa50; san; span", "protein_names_uniprotkb": "Probable N-acetyltransferase san; 2.3.1.-; 2.3.1.258; N-epsilon-acetyltransferase san; Protein atado; Protein separation anxiety", "protein_names_refseq": "CG12352-PA; N(alpha)-acetyltransferase 50; atado; complementation group 2; san-PA; separation anxiety", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12352)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10731132;12537569;12537572;14653991;18801358;22851751;23306065;27996020;40245499", "class_list": "", "function": "(Microbial infection) Required for optimal replication of E.chaffeensis in the immune tissues, hemocytes, and fat body., [UniProtKB, PubMed, PubMed]; N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine (By similarity). Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides (By similarity). Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins. Autoacetylates (PubMed:14653991). Required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together (PubMed:14653991, PubMed:18801358, PubMed:27996020). Required for the interaction between Scc1/vtd and SMC3, possibly by mediating N-terminal acetylation of Scc1/vtd (PubMed:27996020)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.256", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.256", "type": "external" }, { "id": "2.3.1.258", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.258", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0008080 N-acetyltransferase activity;GO:0004596 protein-N-terminal amino-acid acetyltransferase activity;GO:0120518 protein N-terminal-methionine acetyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031415 NatA complex;GO:0031248 protein acetyltransferase complex", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007064 mitotic sister chromatid cohesion;GO:0006474 N-terminal protein amino acid acetylation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9NHD5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9NJG9-1", "uniprot_id": [ { "id": "SUZ12_DROME", "url": "https://www.uniprot.org/uniprot/Q9NJG9", "type": "external" } ], "mass": 100104.0, "length": 900, "protein_name": "Polycomb protein Su(z)12", "gene_name": "Su(z)12", "organism": "Fruit fly", "refseq_name": "Su(z)12, isoform A", "refseq_ac": [ { "id": "NP_652059", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_652059", "type": "external" } ], "gene_names_uniprotkb": "Su(z)12; CG8013", "gene_names_refseq": "CG8013; Dmel\\CG8013; SU(Z)12; SUZ12; Su(Z)12; Su(z)12; Su(z)[12]; Su(z); Suz(12); Suz12; l(3)76BDo; su(z)12", "protein_names_uniprotkb": "Polycomb protein Su(z)12; Suppressor 12 of zeste protein", "protein_names_refseq": "CG8013-PA; Su(z)12, isoform A; Su(z)12-PA; Suppressor-of-zeste-12; suppressor of zeste 12; suppressor of zeste[12]", "tax_id": 7227, "disease": "spina bifida (Disease Ontology:DOID:0080016); renal Wilms' tumor (Disease Ontology:DOID:5176)", "pathway": " (dme:Dmel_CG8013); (R-DME-212300); (R-DME-2559580); (R-DME-8943724); (R-DME-8953750); (R-DME-9764725); (R-DME-9909649)", "pathway_count": 7, "publication_count": 9, "publication_id_list": "10731132;11546753;12408863;12408864;12537569;12537572;12697833;17372656;22354997", "class_list": "", "function": "Polycomb group (PcG) protein. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. Component of the Esc/E(z) complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8T9D8;Q9VW55", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0035098 ESC/E(Z) complex;GO:0035097 histone methyltransferase complex;GO:0016586 RSC-type complex", "go_biological_process": "GO:2001229 negative regulation of response to gamma radiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0022008 neurogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9NJG9-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9TVP3-1", "uniprot_id": [ { "id": "JDP_DROME", "url": "https://www.uniprot.org/uniprot/Q9TVP3", "type": "external" } ], "mass": 21651.0, "length": 195, "protein_name": "J domain-containing protein", "gene_name": "jdp", "organism": "Fruit fly", "refseq_name": "jdp, isoform A", "refseq_ac": [ { "id": "NP_651807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651807", "type": "external" } ], "gene_names_uniprotkb": "jdp; CG2239", "gene_names_refseq": "CG2239; Dmel\\CG2239; JDP; dJDP; jdp; p25a", "protein_names_uniprotkb": "J domain-containing protein; dJDP", "protein_names_refseq": "CG2239-PA; jdp, isoform A; jdp-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2239)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10542335;10731132;10760603;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IMI1;Q9V3I7", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9TVP3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9TVQ5-1", "uniprot_id": [ { "id": "SPT4H_DROME", "url": "https://www.uniprot.org/uniprot/Q9TVQ5", "type": "external" } ], "mass": 13332.0, "length": 116, "protein_name": "Transcription elongation factor SPT4", "gene_name": "spt4", "organism": "Fruit fly", "refseq_name": "spt4", "refseq_ac": [ { "id": "NP_610802", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610802", "type": "external" } ], "gene_names_uniprotkb": "spt4; CG12372", "gene_names_refseq": "142904_at; CG12372; DSIF; Dmel\\CG12372; Dspt4; SPT4; Spt4; dDSIF; dSpt4; dspt4; l(2)k05316; spt4", "protein_names_uniprotkb": "Transcription elongation factor SPT4; DRB sensitivity-inducing factor small subunit; DSIF small subunit; dSpt4", "protein_names_refseq": "CG12372-PA; DSIF; spt4-PA; spt4", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12372); (R-DME-112382); (R-DME-113418); (R-DME-674695); (R-DME-6796648); (R-DME-75955)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;15056674", "class_list": "", "function": "Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF may also promote transcriptional elongation within coding regions. DSIF is required for the transcriptional induction of heat shock response genes and regulation of genes which control anterior-posterior patterning during embryonic development (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9V6E5", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0032044 DSIF complex;GO:0005634 nucleus;GO:0008023 transcription elongation factor complex;GO:0005703 polytene chromosome puff;GO:0005705 polytene chromosome interband", "go_biological_process": "GO:0032785 negative regulation of DNA-templated transcription, elongation;GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9TVQ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9U3W6-1", "uniprot_id": [ { "id": "MAB21_DROME", "url": "https://www.uniprot.org/uniprot/Q9U3W6", "type": "external" } ], "mass": 41863.0, "length": 365, "protein_name": "Protein mab-21", "gene_name": "mab-21", "organism": "Fruit fly", "refseq_name": "mab-21", "refseq_ac": [ { "id": "NP_651971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651971", "type": "external" } ], "gene_names_uniprotkb": "mab-21; CG4746", "gene_names_refseq": "CG4746; Dmel\\CG4746; mab-21; mab-2", "protein_names_uniprotkb": "Protein mab-21", "protein_names_refseq": "CG4746-PA; mab-21-PA; mab-21", "tax_id": 7227, "disease": "syndromic microphthalmia 14 (Disease Ontology:DOID:0111802); microphthalmia (Disease Ontology:DOID:10629); coloboma (Disease Ontology:DOID:12270)", "pathway": " (dme:Dmel_CG4746)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W447", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0001654 eye development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9U3W6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9U5L1-1", "uniprot_id": [ { "id": "SRPRA_DROME", "url": "https://www.uniprot.org/uniprot/Q9U5L1", "type": "external" } ], "mass": 67795.0, "length": 614, "protein_name": "Signal recognition particle receptor subunit alpha homolog", "gene_name": "SrpRalpha", "organism": "Fruit fly", "refseq_name": "signal recognition particle receptor alpha", "refseq_ac": [ { "id": "NP_524887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524887", "type": "external" } ], "gene_names_uniprotkb": "SrpRalpha; CG2522; Gtp-bp", "gene_names_refseq": "BEST:CK00309; CG2522; CK00309; Dmel\\CG2522; GTP-bp; Gtp-bp; SrpRalpha; mAb 13D5", "protein_names_uniprotkb": "Signal recognition particle receptor subunit alpha homolog; DP-alpha; Docking protein alpha; GTP-binding protein; SR-alpha", "protein_names_refseq": "CG2522-PA; GTP binding protein; GTP-binding protein; SrpRalpha-PA; signal recognition particle receptor alpha", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2522)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;18327897;8360279", "class_list": "", "function": "Component of the SRP (signal recognition particle) receptor (By similarity). Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit Srp54 (By similarity). SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (By similarity). May have a role in axonogenesis (PubMed:8360279)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95RJ8;Q9VZ29", "ec_number_list": [], "go_molecular_function": "GO:0005047 signal recognition particle binding;GO:0003723 RNA binding;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005785 signal recognition particle receptor complex;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007409 axonogenesis;GO:0050708 regulation of protein secretion;GO:0045047 protein targeting to ER;GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9U5L1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V3D2-1", "uniprot_id": [ { "id": "HEM6_DROME", "url": "https://www.uniprot.org/uniprot/Q9V3D2", "type": "external" } ], "mass": 44420.0, "length": 390, "protein_name": "Oxygen-dependent coproporphyrinogen-III oxidase", "gene_name": "Coprox", "organism": "Fruit fly", "refseq_name": "coproporphyrinogen oxidase, isoform B", "refseq_ac": [ { "id": "NP_001285697", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285697", "type": "external" } ], "gene_names_uniprotkb": "Coprox; BcDNA:GM14838; CG3433; Dmel\\CG3433; Dmel_CG3433; l(2)k10617; l(2)k11018", "gene_names_refseq": "BcDNA:GM14838; CG3433; Coprox; Dmel\\CG3433; l(2)k10617; l(2)k11018", "protein_names_uniprotkb": "Oxygen-dependent coproporphyrinogen-III oxidase; 1.3.3.3; COX; Coprogen oxidase; Coproporphyrinogenase", "protein_names_refseq": "CG3433-PB; Coprox-PB; coproporphyrinogen oxidase, isoform B; corpoporphyrinogen III oxidase", "tax_id": 7227, "disease": "hereditary coproporphyria (Disease Ontology:DOID:13269); liver disease (Disease Ontology:DOID:409)", "pathway": " (dme:Dmel_CG3433); (R-DME-189451)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10731132;10731138;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.3", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0004109 coproporphyrinogen oxidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006783 heme biosynthetic process;GO:0006782 protoporphyrinogen IX biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9V3D2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V3F3-1", "uniprot_id": [ { "id": "MTTF_DROME", "url": "https://www.uniprot.org/uniprot/Q9V3F3", "type": "external" } ], "mass": 48281.0, "length": 410, "protein_name": "Transcription termination factor, mitochondrial", "gene_name": "mTTF", "organism": "Fruit fly", "refseq_name": "mitochondrial transcription termination factor", "refseq_ac": [ { "id": "NP_609709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609709", "type": "external" } ], "gene_names_uniprotkb": "mTTF; CG18124", "gene_names_refseq": "BG:DS01068.4; CG18124; DS01068.4; DmTTF; Dmel\\CG18124; TTF; mTTF", "protein_names_uniprotkb": "Transcription termination factor, mitochondrial; Mitochondrial transcription termination factor; mTTF", "protein_names_refseq": "CG18124-PA; mTTF-PA; mitochondrial transcription termination factor", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18124); (R-DME-163316)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10731132;12537569;12537572;12626700;15845400;16648357;19032147;22784680;24068965", "class_list": "", "function": "Transcription termination factor (PubMed:12626700, PubMed:15845400, PubMed:16648357). Binds promoter DNA and regulates mitochondrial replication and transcription (PubMed:12626700, PubMed:15845400, PubMed:16648357, PubMed:24068965). Transcription termination activity may be polarized with highest termination activity occurring when its DNA-binding site is positioned in the reverse orientation with respect to the incoming RNA polymerase (PubMed:15845400). Required for normal topology and maintenance of mitochondrial DNA (mtDNA) levels (PubMed:24068965). Regulates mtDNA replication by promoting replication pausing, possibly by acting as a natural barrier to replication fork progression (PubMed:24068965). Its function in replication pausing prevents unregulated replication that may occur for example by collisions between the machineries of DNA replication and transcription during mtDNA synthesis (PubMed:24068965). This ensures the incorporation of RNA transcripts into replication intermediates at the replication fork and allow for proper fork progression (PubMed:24068965). Shares mtDNA binding sites with the mitochondrial termination factor mTerf5 and thereby may antagonize mTerf5 function during replication to regulate pausing (PubMed:22784680, PubMed:24068965). Likely to function downstream of Dref which activates genes involved in mtDNA replication and maintenance (PubMed:19032147, PubMed:24068965)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q86LS0", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006393 termination of mitochondrial transcription;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9V3F3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V3G1-1", "uniprot_id": [ { "id": "RL8_DROME", "url": "https://www.uniprot.org/uniprot/Q9V3G1", "type": "external" } ], "mass": 27893.0, "length": 256, "protein_name": "Large ribosomal subunit protein uL2", "gene_name": "RpL8", "organism": "Fruit fly", "refseq_name": "ribosomal protein L8, isoform A", "refseq_ac": [ { "id": "NP_524726", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524726", "type": "external" } ], "gene_names_uniprotkb": "RpL8; CG1263", "gene_names_refseq": "CG1263; Dmel\\CG1263; L2; L8; M(3)62F; M(3)LS2; RPL8; Rp L8; RpL8; Rpl8; anon-EST:Posey5; rpL8", "protein_names_uniprotkb": "Large ribosomal subunit protein uL2; 60S ribosomal protein L8", "protein_names_refseq": "CG1263-PA; Minute(3)62F; RpL8-PA; ribosomal protein L8, isoform A; ribosomal protein L8", "tax_id": 7227, "disease": "Diamond-Blackfan anemia (Disease Ontology:DOID:1339)", "pathway": " (dme:Dmel_CG1263); (R-DME-156827); (R-DME-1799339); (R-DME-72689); (R-DME-72706); (R-DME-9629569); (R-DME-975956); (R-DME-975957); (R-DME-9954709); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 11, "publication_count": 5, "publication_id_list": "10333574;10731132;12537569;12537572;23636399", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V1C0", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0022626 cytosolic ribosome;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9V3G1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V3G3-1", "uniprot_id": [ { "id": "PPIE_DROME", "url": "https://www.uniprot.org/uniprot/Q9V3G3", "type": "external" } ], "mass": 33276.0, "length": 300, "protein_name": "Peptidyl-prolyl cis-trans isomerase E", "gene_name": "cyp33", "organism": "Fruit fly", "refseq_name": "cyclophilin-33", "refseq_ac": [ { "id": "NP_523773", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523773", "type": "external" } ], "gene_names_uniprotkb": "cyp33; CG4886", "gene_names_refseq": "CG4886; CYP33; Cyp33; Dcyp33; Dmel\\CG4886; cyp33", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase E; 5.2.1.8; Cyclophilin 33; Cyclophilin E; PPIase E; Rotamase E", "protein_names_refseq": "CG4886-PA; cyclophilin-33; cyp33-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4886); (R-DME-6781823); (R-DME-6782135); (R-DME-6782210); (R-DME-6798695); (R-DME-72163)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "10731132;11976948;12537569;12537572", "class_list": "", "function": "PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Combines RNA-binding and PPIase activities (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "5.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.-", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "5.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "1.11.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.-", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" } ], "go_molecular_function": "GO:0003729 mRNA binding;GO:0016018 cyclosporin A binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0071013 catalytic step 2 spliceosome;GO:0071011 precatalytic spliceosome;GO:0000974 Prp19 complex", "go_biological_process": "GO:0006457 protein folding;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9V3G3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V3G7-1", "uniprot_id": [ { "id": "PSMD6_DROME", "url": "https://www.uniprot.org/uniprot/Q9V3G7", "type": "external" } ], "mass": 45381.0, "length": 389, "protein_name": "26S proteasome non-ATPase regulatory subunit 6", "gene_name": "Rpn7", "organism": "Fruit fly", "refseq_name": "regulatory particle non-ATPase 7", "refseq_ac": [ { "id": "NP_651048", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651048", "type": "external" } ], "gene_names_uniprotkb": "Rpn7; CG5378", "gene_names_refseq": "141231_at; CG5378; Dmel\\CG5378; Rpn7; S10a; anon-WO0172774.103; anon-WO0172774.106; p42A; rpn7", "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 6; 26S proteasome regulatory subunit S10; Protein Rpn7", "protein_names_refseq": "CG5378-PA; Rpn7-PA; regulatory particle non-ATPase 7", "tax_id": 7227, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (dme:Dmel_CG5378); (R-DME-1169091); (R-DME-1234176); (R-DME-1236978); (R-DME-174084); (R-DME-174154); (R-DME-174178); (R-DME-174184); (R-DME-187577); (R-DME-195253); (R-DME-202424); (R-DME-209360); (R-DME-209406); (R-DME-209461); (R-DME-216167); (R-DME-2467813); (R-DME-2871837); (R-DME-350562); (R-DME-382556); (R-DME-432395); (R-DME-432524); (R-DME-432626); (R-DME-450408); (R-DME-4608870); (R-DME-4641257); (R-DME-4641258); (R-DME-5358346); (R-DME-538864); (R-DME-5607761); (R-DME-5607764); (R-DME-5610780); (R-DME-5610785); (R-DME-5632684); (R-DME-5658442); (R-DME-5676590); (R-DME-5689603); (R-DME-5689880); (R-DME-6798695); (R-DME-68867); (R-DME-68949); (R-DME-69017); (R-DME-69601); (R-DME-75815); (R-DME-8854050); (R-DME-8939236); (R-DME-8939902); (R-DME-8941858); (R-DME-8948751); (R-DME-8951664); (R-DME-9020702); (R-DME-9755511); (R-DME-9762114); (R-DME-983168); (R-DME-9907900); (R-DME-9929491); (R-DME-9932298); (R-DME-9954709)", "pathway_count": 57, "publication_count": 35, "publication_id_list": "10102270;10417378;10458606;10481010;10731132;11585911;12231619;12432393;12442174;12537569;12537572;12973300;15178801;15258584;15331761;16139204;16299518;16326393;16386907;16543224;16603629;16651542;16740475;16794082;17102630;17925225;18519643;18593878;19185492;7705656;8948598;9025065;9215627;9553105;9990853", "class_list": "", "function": "Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000502 proteasome complex;GO:0008541 proteasome regulatory particle, lid subcomplex;GO:0005838 proteasome regulatory particle", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "Q9V3G7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V3J4-1", "uniprot_id": [ { "id": "SEC13_DROME", "url": "https://www.uniprot.org/uniprot/Q9V3J4", "type": "external" } ], "mass": 39528.0, "length": 356, "protein_name": "Protein SEC13 homolog", "gene_name": "Sec13", "organism": "Fruit fly", "refseq_name": "secretory 13, isoform B", "refseq_ac": [ { "id": "NP_001287480", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287480", "type": "external" } ], "gene_names_uniprotkb": "Sec13; CG6773", "gene_names_refseq": "BEST:CK00043; BcDNA:LD03471; CG6773; CK00043; Dmel\\CG6773; Dsec13; GATOR2; SEC13; Sec13; l(3)01031; sec13", "protein_names_uniprotkb": "Protein SEC13 homolog; GATOR complex protein SEC13; Secretory protein 13", "protein_names_refseq": "CG6773-PB; Sec13 ortholog; Sec13-PB; sec13; secretory 13, isoform B", "tax_id": 7227, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (dme:Dmel_CG6773); (R-DME-159227); (R-DME-159230); (R-DME-159231); (R-DME-159236); (R-DME-1855170); (R-DME-1855196); (R-DME-1855229); (R-DME-204005); (R-DME-3108214); (R-DME-3301854); (R-DME-3371453); (R-DME-4085377); (R-DME-4551638); (R-DME-9615933)", "pathway_count": 15, "publication_count": 8, "publication_id_list": "10731132;12537569;12537572;20144761;20547758;21898761;27166823;38514639", "class_list": "", "function": "A component of the GATOR subcomplex GATOR2 which functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:27166823). The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the mTORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation (PubMed:27166823). GATOR2 activates the mTORC1 signaling pathway through the inhibition of the GATOR1 subcomplex, controlling the switch to cell proliferation and growth under nutrient replete conditions and during female oocyte development (PubMed:27166823)., [UniProtKB, PubMed]; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (By similarity). Recruited to transcriptionally active chromatin at the time of transcription initiation by RNA polymerase II (PubMed:20144761). Required for proper expression of ecdysone-responsive genes such as Eip74EF and Eip75B during larval development (PubMed:20144761). Required for reactivation of transcription after heat shock (PubMed:20144761). Required for nuclear import of phosphorylated Mad via importin msk (PubMed:20547758). Has no role in classical nuclear localization signal (cNLS)-dependent nuclear import via importin-beta (PubMed:20547758)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7KLW8", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0031080 nuclear pore outer ring;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005813 centrosome", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006913 nucleocytoplasmic transport;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034605 cellular response to heat", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9V3J4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V3N8-1", "uniprot_id": [ { "id": "THG1_DROME", "url": "https://www.uniprot.org/uniprot/Q9V3N8", "type": "external" } ], "mass": 33073.0, "length": 286, "protein_name": "Probable tRNA(His) guanylyltransferase", "gene_name": "Thg", "organism": "Fruit fly", "refseq_name": "tRNA-histidine guanylyltransferase, isoform B", "refseq_ac": [ { "id": "NP_001188815", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001188815", "type": "external" } ], "gene_names_uniprotkb": "Thg; CG4103; l(2)35Bc", "gene_names_refseq": "BG:DS00929.4; C1; CG4103; Dmel\\CG4103; THG; br4; l(2)35Bc; l(2)br11; l(2)br13; l(2)br4; l(2)br; l(2)k08808; tRNA-guanylyltransferase", "protein_names_uniprotkb": "Probable tRNA(His) guanylyltransferase; 2.7.7.79; tRNA-histidine guanylyltransferase", "protein_names_refseq": "CG4103-PB; THG-PB; lethal (2) 35Bc; lethal 11 in the black-reduced region; lethal 13 in the black-reduced region; lethal 4 in the black-reduced region; lethal group C1; tRNA guanylyltransferase; tRNA-histidine guanylyltransferase, isoform B", "tax_id": 7227, "disease": "autosomal recessive cerebellar ataxia (Disease Ontology:DOID:0050950); autosomal recessive spinocerebellar ataxia 28 (Disease Ontology:DOID:0070409); cancer (Disease Ontology:DOID:162)", "pathway": " (dme:Dmel_CG4103)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "M9MSI6", "ec_number_list": [ { "id": "2.7.7.79", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.79", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005525 GTP binding;GO:0008193 tRNA guanylyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0008033 tRNA processing;GO:0006400 tRNA modification", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9V3N8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V3P0-1", "uniprot_id": [ { "id": "PRDX2_DROME", "url": "https://www.uniprot.org/uniprot/Q9V3P0", "type": "external" } ], "mass": 21738.0, "length": 194, "protein_name": "Peroxiredoxin 2", "gene_name": "Prx2", "organism": "Fruit fly", "refseq_name": "peroxiredoxin 2, isoform C", "refseq_ac": [ { "id": "NP_001285202", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285202", "type": "external" } ], "gene_names_uniprotkb": "Prx2; 1633; 4; CG1633; DPx-4783; DPx4783; DmTPx-1; Dmel\\CG1633; Dmel_CG1633; Dpx-4783; JAFRAC 1; Jafrac1; Jafrac; PRDX1_DROME; PRDX1; Prx4783; Prx; SSP5111; T20; TPX-1; cTPx; dPRDX2; dPrx I; dPrx1; dPrx2; jafrac1; jf1", "gene_names_refseq": "1633; CG1633; DPx-4783; DPx4783; DmTPx-1; Dmel\\CG1633; Dpx-4783; JAFRAC 1; Jafrac1; Jafrac; PRDX1/2/4; PRDX1_DROME; PRDX1; Prx2; Prx4783; Prx; SSP5111; T20; TPX-1; cTPx; dPRDX2; dPrx I; dPrx1; dPrx2; jafrac1; jf1", "protein_names_uniprotkb": "Peroxiredoxin 2; 1.11.1.24; Cytosolic thioredoxin peroxidase 1; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1; Thioredoxin-dependent peroxiredoxin 2", "protein_names_refseq": "CG1633-PC; Jafrac-1; Prx2-PC; jafrac1; peroxidase; peroxiredoxin 1; peroxiredoxin 2, isoform C; peroxiredoxin 4783; peroxiredoxin I; thioredoxin peroxidase 1", "tax_id": 7227, "disease": "methylmalonic aciduria and homocystinuria type cblC (Disease Ontology:DOID:0050715); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dme:Dmel_CG1633); (R-DME-3299685); (R-DME-5628897); (R-DME-9818027)", "pathway_count": 4, "publication_count": 18, "publication_id_list": "10632718;10731132;11677042;11877442;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;26715182;28953965", "class_list": "", "function": "Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0KHT0", "ec_number_list": [ { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "1.8.98.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.98.2", "type": "external" } ], "go_molecular_function": "GO:0051920 peroxiredoxin activity;GO:0008379 thioredoxin peroxidase activity;GO:0140824 thioredoxin-dependent peroxiredoxin activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0007155 cell adhesion;GO:0042594 response to starvation;GO:0045454 cell redox homeostasis;GO:0007281 germ cell development", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9V3P0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V3R8-1", "uniprot_id": [ { "id": "UBIA1_DROME", "url": "https://www.uniprot.org/uniprot/Q9V3R8", "type": "external" } ], "mass": 39216.0, "length": 359, "protein_name": "UbiA prenyltransferase domain-containing protein 1 homolog", "gene_name": "heix", "organism": "Fruit fly", "refseq_name": "heixuedian", "refseq_ac": [ { "id": "NP_523581", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523581", "type": "external" } ], "gene_names_uniprotkb": "heix; CG5876", "gene_names_refseq": "124/1; 2L1; BG:DS02740.7; CG5876; Dmel\\CG5876; heix; ipa-6d; l(2)35Fc; l(2)k12401", "protein_names_uniprotkb": "UbiA prenyltransferase domain-containing protein 1 homolog; 2.5.1.-; Protein heixuedian", "protein_names_refseq": "CG5876-PA; heix-PA; heixuedian; lethal(2)35Fc", "tax_id": 7227, "disease": "lymphoma (Disease Ontology:DOID:0060058); Schnyder corneal dystrophy (Disease Ontology:DOID:0060456)", "pathway": " (dme:Dmel_CG5876); (R-DME-6806664)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;22582012", "class_list": "", "function": "Prenyltransferase that mediates the formation of menaquinone-4 (MK-4), a vitamin K2 isoform, thereby acting as a mitochondrial electron carrier. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. MK-4 acts as a membrane electron carrier downstream of a electron transport chain complex, improving mitochondrial oxygen consumption., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0004659 prenyltransferase activity;GO:0120566 menadiol geranylgeranyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0007005 mitochondrion organization;GO:0006744 ubiquinone biosynthetic process;GO:0009234 menaquinone biosynthetic process;GO:0042371 vitamin K biosynthetic process;GO:0035204 negative regulation of lamellocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9V3R8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V3V7-1", "uniprot_id": [ { "id": "SPC25_DROME", "url": "https://www.uniprot.org/uniprot/Q9V3V7", "type": "external" } ], "mass": 25742.0, "length": 222, "protein_name": "Kinetochore protein Spc25", "gene_name": "Spc25", "organism": "Fruit fly", "refseq_name": "Spc25", "refseq_ac": [ { "id": "NP_650239", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650239", "type": "external" } ], "gene_names_uniprotkb": "Spc25; CG7242; Cal2; mitch", "gene_names_refseq": "BcDNA:LD37196; CG7242; Cal2; Dmel\\CG7242; Mitch; S3; Spc25; cal2; dmSpc25R; l(3)87Da; l(3)A34-1; l(3)A46-1; l(3)S3; l(3)c00064; spc25", "protein_names_uniprotkb": "Kinetochore protein Spc25; Chromosome alignment defect 2; Mitotic chaos", "protein_names_refseq": "CG7242-PA; Spc25-PA; Spc25; chromosome alignment defect 2; lethal (3) 87Da; lethal (3) c00064; mitch; mitotic chaos", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7242)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537572;17333235;17412918;17895365", "class_list": "", "function": "Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis (PubMed:17333235, PubMed:17895365). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:17333235, PubMed:17895365). Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics (PubMed:17333235). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031262 Ndc80 complex;GO:0005634 nucleus;GO:0000776 kinetochore", "go_biological_process": "GO:0007059 chromosome segregation;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0007080 mitotic metaphase chromosome alignment;GO:0000212 meiotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9V3V7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V3Z2-1", "uniprot_id": [ { "id": "SER7_DROME", "url": "https://www.uniprot.org/uniprot/Q9V3Z2", "type": "external" } ], "mass": 43128.0, "length": 391, "protein_name": "Serine protease 7", "gene_name": "Sp7", "organism": "Fruit fly", "refseq_name": "serine protease 7, isoform A", "refseq_ac": [ { "id": "NP_649734", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649734", "type": "external" } ], "gene_names_uniprotkb": "Sp7; CG3066; MP2; PAE1", "gene_names_refseq": "CG3066; Dmel\\CG3066; MP1; MP2/sp7/PAE1; MP2; PAE1; PAE; SP13; SP7; Sp 7; Sp7; anon-Ryu; cSP7; proPO-AE; sp7", "protein_names_uniprotkb": "Serine protease 7; 3.4.21.-; Melanization protease 2", "protein_names_refseq": "CG3066-PA; Sp7-PA; melanization protease 2; prophenoloxidase-activating enzyme 1; serine protease 7, isoform A; serine protease 7; serine protease-7", "tax_id": 7227, "disease": "intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (dme:Dmel_CG3066)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537569;12537572;15579698;16256951;16322759;16861233;18854145;19071960;22227521;24260243", "class_list": "", "function": "Serine protease that, by cleaving and activating prophenoloxidase (PPO1) after immune challenge, plays an essential role in the melanization immune response to septic wounding (PubMed:16256951, PubMed:16322759, PubMed:16861233, PubMed:19071960, PubMed:24260243). May function in diverse Hayan-dependent PPO1-activating cascades that are negatively controlled by different serpin proteins; Spn27A in the hemolymph and Spn77BA in the trachea (PubMed:16322759, PubMed:18854145, PubMed:24260243). Important for the innate immune response to fungi (PubMed:16861233). Regulation of melanization and PPO1 activation appears to be largely independent of the Toll signaling pathway (PubMed:16861233)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F7VJU2;Q6BD09;Q95SU8;Q9I7L2", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0050830 defense response to Gram-positive bacterium;GO:0035008 positive regulation of melanization defense response;GO:0035006 melanization defense response", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9V3Z2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V422-1", "uniprot_id": [ { "id": "RYK2_DROME", "url": "https://www.uniprot.org/uniprot/Q9V422", "type": "external" } ], "mass": 64938.0, "length": 584, "protein_name": "Inactive tyrosine-protein kinase Dnt", "gene_name": "dnt", "organism": "Fruit fly", "refseq_name": "doughnut on 2, isoform B", "refseq_ac": [ { "id": "NP_001260567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260567", "type": "external" } ], "gene_names_uniprotkb": "dnt; CG17559", "gene_names_refseq": "CG17559; DNT; Dmel\\CG17559; Dnt; dnt", "protein_names_uniprotkb": "Inactive tyrosine-protein kinase Dnt; Protein doughnut", "protein_names_refseq": "CG17559-PB; dnt-PB; doughnut on 2, isoform B; doughnut on 2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17559); (R-DME-201681)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10231580;10731132;11135307;12537569;12537572;9858720", "class_list": "", "function": "May play an essential role in neuronal pathway recognition and ventral muscle attachment site selection., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B9EQS2;M9PG69;O62533;Q5BII5;Q95TI0", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0046982 protein heterodimerization activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0007165 signal transduction;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007409 axonogenesis;GO:0010976 positive regulation of neuron projection development;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9V422-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V438-1", "uniprot_id": [ { "id": "PDIA6_DROME", "url": "https://www.uniprot.org/uniprot/Q9V438", "type": "external" } ], "mass": 46752.0, "length": 433, "protein_name": "Protein disulfide-isomerase A6 homolog", "gene_name": "CaBP1", "organism": "Fruit fly", "refseq_name": "calcium-binding protein 1, isoform B", "refseq_ac": [ { "id": "NP_001285979", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285979", "type": "external" } ], "gene_names_uniprotkb": "CaBP1; CG5809", "gene_names_refseq": "AAL28897; BG:DS09218.4; CG5809; CaBP1; CaBp1; DmCaBP1; Dmel\\CG5809", "protein_names_uniprotkb": "Protein disulfide-isomerase A6 homolog; 5.3.4.1; Calcium-binding protein 1; DmCaBP1", "protein_names_refseq": "CG5809-PB; CaBP1-PB; calcium-binding protein 1, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5809); (R-DME-381426); (R-DME-8957275)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;22158613;9770267", "class_list": "", "function": "Binds to both apoptotic cells and phagocytes and promotes Drpr-dependent phagocytosis of apoptotic cells., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.14.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.18.1", "type": "external" }, { "id": "1.10.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.10.3.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "1.10.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.10.3.3", "type": "external" }, { "id": "3.4.21.112", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.112", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "2.4.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.145", "type": "external" }, { "id": "3.1.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.98", "type": "external" } ], "go_molecular_function": "GO:0015035 protein-disulfide reductase activity;GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0009986 cell surface;GO:0012505 endomembrane system", "go_biological_process": "GO:0006909 phagocytosis;GO:0034976 response to endoplasmic reticulum stress;GO:2000427 positive regulation of apoptotic cell clearance", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9V438-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V460-1", "uniprot_id": [ { "id": "SPT5H_DROME", "url": "https://www.uniprot.org/uniprot/Q9V460", "type": "external" } ], "mass": 119445.0, "length": 1078, "protein_name": "Transcription elongation factor SPT5", "gene_name": "Spt5", "organism": "Fruit fly", "refseq_name": "Spt5", "refseq_ac": [ { "id": "NP_652610", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_652610", "type": "external" } ], "gene_names_uniprotkb": "Spt5; CG7626", "gene_names_refseq": "CG7626; DSIF; Dmel\\CG7626; Dspt5; SPT5; Spt5; dDSIF; dSpt5; spt5", "protein_names_uniprotkb": "Transcription elongation factor SPT5; DRB sensitivity-inducing factor large subunit; DSIF large subunit; dSpt5", "protein_names_refseq": "CG7626-PA; Spt5-PA; Spt5; complementation group C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7626); (R-DME-112382); (R-DME-113418); (R-DME-674695); (R-DME-6796648); (R-DME-72086); (R-DME-75955); (R-DME-77075)", "pathway_count": 8, "publication_count": 16, "publication_id_list": "10731132;11040216;11040217;12490954;12537569;12537572;12782658;12934007;14730313;15056674;15380072;15741180;17372656;18327897;23209435;32966759", "class_list": "", "function": "Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF may also promote transcriptional elongation within coding regions. DSIF is required for the transcriptional induction of heat shock response genes and regulation of genes which control anterior-posterior patterning during embryonic development., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8IGQ1;Q8T0P5", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003729 mRNA binding;GO:0046982 protein heterodimerization activity;GO:0044877 protein-containing complex binding;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0032044 DSIF complex;GO:0005634 nucleus;GO:0008023 transcription elongation factor complex;GO:0005703 polytene chromosome puff;GO:0005705 polytene chromosome interband", "go_biological_process": "GO:0032785 negative regulation of DNA-templated transcription, elongation;GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9V460-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V463-1", "uniprot_id": [ { "id": "NU154_DROME", "url": "https://www.uniprot.org/uniprot/Q9V463", "type": "external" } ], "mass": 153895.0, "length": 1365, "protein_name": "Nuclear pore complex protein Nup154", "gene_name": "Nup154", "organism": "Fruit fly", "refseq_name": "nucleoporin 154kD, isoform D", "refseq_ac": [ { "id": "NP_001285827", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285827", "type": "external" } ], "gene_names_uniprotkb": "Nup154; CG4579; Nup155", "gene_names_refseq": "BcDNA:LD21772; CG4579; Dmel\\CG4579; NUP154; Nup154; Nup155; Nup32D; Nup; l(2)01501; l(2)10432; ms(2)zk; nup154; nup32D; tip; tlp; zk", "protein_names_uniprotkb": "Nuclear pore complex protein Nup154; 154 kDa nucleoporin; Nucleoporin Nup154; Tulipan", "protein_names_refseq": "CG4579-PD; Nup154-PD; nucleoporin 154kD, isoform D; nucleoporin 154; tulipano; zonder kloten", "tax_id": 7227, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650)", "pathway": " (dme:Dmel_CG4579); (R-DME-159227); (R-DME-159230); (R-DME-159231); (R-DME-159236); (R-DME-1855170); (R-DME-1855196); (R-DME-1855229); (R-DME-3108214); (R-DME-3301854); (R-DME-3371453); (R-DME-4085377); (R-DME-4551638); (R-DME-4615885); (R-DME-9615933)", "pathway_count": 15, "publication_count": 10, "publication_id_list": "10511559;10731132;10731138;12537572;17277377;17410542;21696798;22718353;26341556;9732281", "class_list": "", "function": "Component of the nuclear pore complex (PubMed:17410542). Has a role in the organization of the inner nuclear membrane proteins at the nuclear envelope (PubMed:22718353). In germ cells, plays a role in the nuclear localization of components of the dpp signaling pathways, such as Medea and phosphorylated Mad (PubMed:21696798). Binds to chromatin, and together with Nup62 and Nup93-1, contributes to karyosome morphology and chromatin organization including attachment to the nuclear envelope in oocytes and nurse cells (PubMed:22718353, PubMed:26341556). Has a role in female fertility including egg chamber development; in nurse cells, has a role in the organization of F-actin in subcortical and cytoplasmic actin filaments important for the transfer of cytoplasm from nurse cells to the growing oocytes (PubMed:10511559, PubMed:17277377, PubMed:17410542, PubMed:9732281). Has a role in male spermatogenesis and fertility (PubMed:10511559, PubMed:9732281). Has a role in germ line cell proliferation (PubMed:21696798)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O62536;O62610;O62613;Q9VKL5", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005737 cytoplasm;GO:0031965 nuclear membrane", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0006913 nucleocytoplasmic transport;GO:0007015 actin filament organization;GO:0007283 spermatogenesis;GO:0007281 germ cell development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9V463-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V4C8-1", "uniprot_id": [ { "id": "HCF_DROME", "url": "https://www.uniprot.org/uniprot/Q9V4C8", "type": "external" } ], "mass": 160185.0, "length": 1500, "protein_name": "Host cell factor", "gene_name": "Hcf", "organism": "Fruit fly", "refseq_name": "host cell factor, isoform E", "refseq_ac": [ { "id": "NP_001245420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245420", "type": "external" } ], "gene_names_uniprotkb": "Hcf; CG1710", "gene_names_refseq": "CG1710; Dmel\\CG1710; HCF1; HCF_DROME; HCF; Hcf1; Hcf; anon-WO0172774.48; dHCF; dHcf1; dHcf", "protein_names_uniprotkb": "Host cell factor; dHcf", "protein_names_refseq": "CG1710-PE; FBgn0039904; Hcf-PE; heat cell factor; host cell factor 1; host cell factor, isoform E; host cell factor", "tax_id": 7227, "disease": "methylmalonic acidemia and homocysteinemia cblX type (Disease Ontology:DOID:0111814); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (dme:Dmel_CG1710); (R-DME-3214847); (R-DME-5689603); (R-DME-9772755)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "10731132;12494450;12537569;12537572;12609738;18327268;18327897;21694722;21875999;26348912;27918560;28604694;32432549;33925313;40245499", "class_list": "", "function": "Component of a SWR1-like complex that incorporates H2A.V genome-wide and specifically at active promoters, in an ATP-dependent manner., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 26, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 26, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 26, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 26, "binding_glycan_count": 0, "secondary_ac_list": "A4V109;H9XVN5;Q8IGU2;Q95S26;Q95ZF3;Q9BKH1", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0035097 histone methyltransferase complex;GO:0044666 MLL3/4 complex;GO:0048188 Set1C/COMPASS complex;GO:0044665 MLL1/2 complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0045927 positive regulation of growth", "synthesized_glycan_count": 0, "hit_score": 4.3, "record_id": "Q9V4C8-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V4Q8-1", "uniprot_id": [ { "id": "RU2A_DROME", "url": "https://www.uniprot.org/uniprot/Q9V4Q8", "type": "external" } ], "mass": 29744.0, "length": 265, "protein_name": "Probable U2 small nuclear ribonucleoprotein A'", "gene_name": "U2A", "organism": "Fruit fly", "refseq_name": "U2A", "refseq_ac": [ { "id": "NP_610315", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610315", "type": "external" } ], "gene_names_uniprotkb": "U2A; CG1406", "gene_names_refseq": "BcDNA:RE56869; CG1406; Dmel\\CG1406; U2A'; U2A-prime; U2A; dU2A'; dU2A; l(2)43Ee; u2a", "protein_names_uniprotkb": "Probable U2 small nuclear ribonucleoprotein A'; U2 snRNP A'", "protein_names_refseq": "CG1406-PA; U2A-PA; U2A; lethal(2)43Ee", "tax_id": 7227, "disease": "azoospermia (Disease Ontology:DOID:14227); connective tissue disease (Disease Ontology:DOID:65)", "pathway": " (dme:Dmel_CG1406); (R-DME-72163); (R-DME-9770562); (R-DME-9943411)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;18621711;24244416;27035939", "class_list": "", "function": "Involved in pre-mRNA splicing as component of the spliceosome (By similarity). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (By similarity). In the germ line, has a role in oogenesis, by regulating spermatogenesis and nurse cell nuclei chromatin decondensation and dispersal, probably by regulating the splicing of proteins necessary for germline differentiation such as the meiotic protein mei-P26 (PubMed:24244416, PubMed:27035939)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030620 U2 snRNA binding", "go_cellular_component": "GO:0071013 catalytic step 2 spliceosome;GO:0005686 U2 snRNP;GO:0071011 precatalytic spliceosome;GO:0030532 small nuclear ribonucleoprotein complex", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006325 chromatin organization;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9V4Q8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V4X2-1", "uniprot_id": [ { "id": "PGSC2_DROME", "url": "https://www.uniprot.org/uniprot/Q9V4X2", "type": "external" } ], "mass": 19829.0, "length": 184, "protein_name": "Peptidoglycan-recognition protein SC2", "gene_name": "PGRP-SC2", "organism": "Fruit fly", "refseq_name": "peptidoglycan recognition protein SC2", "refseq_ac": [ { "id": "NP_610410", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610410", "type": "external" } ], "gene_names_uniprotkb": "PGRP-SC2; CG14745", "gene_names_refseq": "CG14745 PGRP; CG14745; Dmel\\CG14745; PCRP-SC2; PGRP SC; PGRP-SC2; PGRP-SC; pgrp-sc2; pgrp-sc", "protein_names_uniprotkb": "Peptidoglycan-recognition protein SC2; 3.5.1.28", "protein_names_refseq": "CG14745-PA; PGRP-SC2-PA; Peptidoglycan-recognition protein-SC2 precursor; peptidoglycan recognition protein SC2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14745); (R-DME-6798695); (R-DME-6803157)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10731132;11106397;12032070;12537572;14738318", "class_list": "", "function": "N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Probably plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q70PT2;Q70PT3;Q70PT5;Q70PT6", "ec_number_list": [ { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.5.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.28", "type": "external" }, { "id": "3.2.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.14", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "3.4.17.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.13", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0042834 peptidoglycan binding;GO:0008745 N-acetylmuramoyl-L-alanine amidase activity;GO:0008270 zinc ion binding;GO:0016019 peptidoglycan immune receptor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006955 immune response;GO:0045087 innate immune response;GO:0050830 defense response to Gram-positive bacterium;GO:0009253 peptidoglycan catabolic process;GO:0002814 negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9V4X2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V535-1", "uniprot_id": [ { "id": "RBM8A_DROME", "url": "https://www.uniprot.org/uniprot/Q9V535", "type": "external" } ], "mass": 19010.0, "length": 165, "protein_name": "RNA-binding protein 8A", "gene_name": "tsu", "organism": "Fruit fly", "refseq_name": "tsunagi", "refseq_ac": [ { "id": "NP_610454", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610454", "type": "external" } ], "gene_names_uniprotkb": "tsu; CG8781; Y14", "gene_names_refseq": "CG8781; Dmel\\CG8781; TSU; Tsu; Y14/Tsunagi; Y14; cg8781; dY14; tsu; y14", "protein_names_uniprotkb": "RNA-binding protein 8A; Protein tsunagi", "protein_names_refseq": "CG8781-PA; Y14; tsu-PA; tsunagi", "tax_id": 7227, "disease": "thrombocytopenia-absent radius syndrome (Disease Ontology:DOID:14699)", "pathway": " (dme:Dmel_CG8781); (R-DME-159236); (R-DME-72163); (R-DME-975957)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10731132;11691839;12537569;12537572;12704080;12730685;14968132;14973490;20946982;20946983;24967911", "class_list": "", "function": "Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs (PubMed:14973490, PubMed:24967911). Involved in exon definition of genes containing long introns, including the rolled/MAPK gene (PubMed:20946982, PubMed:20946983). The mago-tsu heterodimer interacts with the EJC key regulator Pym leading to EJC disassembly in the cytoplasm (PubMed:24967911). Has a role in oskar mRNA localization to the posterior pole of the developing oocyte (PubMed:11691839)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SZA6;Q95X08", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0071013 catalytic step 2 spliceosome;GO:0035145 exon-exon junction complex", "go_biological_process": "GO:0051170 import into nucleus;GO:0008380 RNA splicing;GO:0000226 microtubule cytoskeleton organization;GO:0000398 mRNA splicing, via spliceosome;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9V535-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V568-1", "uniprot_id": [ { "id": "OR45A_DROME", "url": "https://www.uniprot.org/uniprot/Q9V568", "type": "external" } ], "mass": 43339.0, "length": 378, "protein_name": "Odorant receptor 45a", "gene_name": "Or45a", "organism": "Fruit fly", "refseq_name": "odorant receptor 45a", "refseq_ac": [ { "id": "NP_523666", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523666", "type": "external" } ], "gene_names_uniprotkb": "Or45a; CG1978", "gene_names_refseq": "45C.1; 45a; CG1978; DOR58; Dmel\\CG1978; Or45a", "protein_names_uniprotkb": "Odorant receptor 45a", "protein_names_refseq": "CG1978-PA; Or45a-PA; odorant receptor 45a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1978)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537572;20577637;21613503;21857978", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to hexanol, pentyl acetate, benzyl acetate, and 2-heptanone., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9V568-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V589-1", "uniprot_id": [ { "id": "OR45B_DROME", "url": "https://www.uniprot.org/uniprot/Q9V589", "type": "external" } ], "mass": 46324.0, "length": 396, "protein_name": "Odorant receptor 45b", "gene_name": "Or45b", "organism": "Fruit fly", "refseq_name": "odorant receptor 45b", "refseq_ac": [ { "id": "NP_523667", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523667", "type": "external" } ], "gene_names_uniprotkb": "Or45b; CG12931", "gene_names_refseq": "45F.1; 45b; CG12931; DOR107; Dmel\\CG12931; Or45b", "protein_names_uniprotkb": "Odorant receptor 45b", "protein_names_refseq": "CG12931-PA; Or45b-PA; odorant receptor 45b", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12931)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;21613503;21857978", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to anisole., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9V589-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V597-1", "uniprot_id": [ { "id": "RL31_DROME", "url": "https://www.uniprot.org/uniprot/Q9V597", "type": "external" } ], "mass": 14533.0, "length": 124, "protein_name": "Large ribosomal subunit protein eL31", "gene_name": "RpL31", "organism": "Fruit fly", "refseq_name": "ribosomal protein L31, isoform B", "refseq_ac": [ { "id": "NP_610503", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610503", "type": "external" } ], "gene_names_uniprotkb": "RpL31; CG1821", "gene_names_refseq": "BcDNA:RE59131; CG1821; Dmel\\CG1821; L31e; M(2)45F; Rp L31; RpL31; anon-EST:Posey68; l(2)SH0497; l(2)SH2 0497", "protein_names_uniprotkb": "Large ribosomal subunit protein eL31; 60S ribosomal protein L31", "protein_names_refseq": "CG1821-PB; RpL31-PB; lethal (2) SH0497; ribosomal protein L31, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1821); (R-DME-156827); (R-DME-1799339); (R-DME-72689); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954709); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 10, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;18327897;23636399", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4UZ96;Q0E9E4", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022626 cytosolic ribosome;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9V597-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V5Q4-1", "uniprot_id": [ { "id": "SYF2_DROME", "url": "https://www.uniprot.org/uniprot/Q9V5Q4", "type": "external" } ], "mass": 26537.0, "length": 226, "protein_name": "Pre-mRNA-splicing factor Syf2", "gene_name": "Syf2", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_610617", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610617", "type": "external" } ], "gene_names_uniprotkb": "Syf2; CG12343", "gene_names_refseq": "CG12343; Dmel\\CG12343; Syf2", "protein_names_uniprotkb": "Pre-mRNA-splicing factor Syf2", "protein_names_refseq": "CG12343-PA; uncharacterized protein", "tax_id": 7227, "disease": "encephalitis (Disease Ontology:DOID:9588)", "pathway": " (dme:Dmel_CG12343); (R-DME-72163)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Involved in pre-mRNA splicing as component of the spliceosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0071013 catalytic step 2 spliceosome;GO:0071011 precatalytic spliceosome;GO:0071014 post-mRNA release spliceosomal complex;GO:0071007 U2-type catalytic step 2 spliceosome;GO:0000974 Prp19 complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9V5Q4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V6B9-1", "uniprot_id": [ { "id": "NUP54_DROME", "url": "https://www.uniprot.org/uniprot/Q9V6B9", "type": "external" } ], "mass": 64397.0, "length": 610, "protein_name": "Probable nucleoporin Nup54", "gene_name": "Nup54", "organism": "Fruit fly", "refseq_name": "nucleoporin 54kD", "refseq_ac": [ { "id": "NP_610783", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610783", "type": "external" } ], "gene_names_uniprotkb": "Nup54; CG8831", "gene_names_refseq": "CG8831; Dmel\\CG8831; NUP54; Nup54; nup54", "protein_names_uniprotkb": "Probable nucleoporin Nup54", "protein_names_refseq": "CG8831-PA; Nup54-PA; nucleoporin 54kD; nucleoporin 54", "tax_id": 7227, "disease": "dystonia 37, early-onset with striatal lesions (Disease Ontology:DOID:0060956)", "pathway": " (dme:Dmel_CG8831); (R-DME-159227); (R-DME-159230); (R-DME-159231); (R-DME-159236); (R-DME-1855170); (R-DME-1855196); (R-DME-1855229); (R-DME-3108214); (R-DME-3301854); (R-DME-3371453); (R-DME-4085377); (R-DME-4551638); (R-DME-4615885)", "pathway_count": 14, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;17682050;33856346;33925313", "class_list": "", "function": "Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (PubMed:17682050). Essential for the nuclear import of nuclear localization signal (NLS)-containing proteins in an importin alpha/importin beta-dependent manner (PubMed:17682050). Together with Nup58, required for transposable element silencing regulation in ovarian follicle cells (PubMed:33856346). By interacting with the nuclear (Nxf1/Nxt1) and cytosolic (fs(1)Yb) components of the flamenco (flam) transcripts processing pathway, enables export and subsequent piRNA production (PubMed:33856346)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0044613 nuclear pore central transport channel", "go_biological_process": "GO:0006999 nuclear pore organization;GO:0006913 nucleocytoplasmic transport;GO:0006605 protein targeting;GO:0051028 mRNA transport;GO:0036228 protein localization to nuclear inner membrane", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9V6B9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V6K3-1", "uniprot_id": [ { "id": "ROR2_DROME", "url": "https://www.uniprot.org/uniprot/Q9V6K3", "type": "external" } ], "mass": 81837.0, "length": 724, "protein_name": "Tyrosine-protein kinase transmembrane receptor Ror2", "gene_name": "Nrk", "organism": "Fruit fly", "refseq_name": "neurospecific receptor kinase", "refseq_ac": [ { "id": "NP_477255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477255", "type": "external" } ], "gene_names_uniprotkb": "Nrk; CG4007; ROR2", "gene_names_refseq": "CG4007; DNRK; DmHD-434; Dmel\\CG4007; Dnrk; HD-434; Nrk; ROR2; anon-WO2004063362.79; l(2)k14301; nrk; nrtk_dros", "protein_names_uniprotkb": "Tyrosine-protein kinase transmembrane receptor Ror2; 2.7.10.1; Neurospecific receptor tyrosine kinase; dRor2", "protein_names_refseq": "CG4007-PA; Nrk-PA; drosophila neurospecific receptor kinase; neuronal receptor kinase; neurospecific receptor kinase; neurospecific receptor tyrosine kinase; neurotrophic receptor kinase; neurotropic receptor kinase", "tax_id": 7227, "disease": "congenital myasthenic syndrome 9 (Disease Ontology:DOID:0110670); fetal akinesia deformation sequence syndrome 1 (Disease Ontology:DOID:0111377); myasthenia gravis (Disease Ontology:DOID:437)", "pathway": " (dme:Dmel_CG4007)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;9115253;9731193", "class_list": "", "function": "Tyrosine-protein kinase receptor that functions during early stages of neuronal development., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B3LF77;O02001;O96391;Q9TYH9", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0017147 Wnt-protein binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0007165 signal transduction;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0046716 muscle cell cellular homeostasis;GO:0042052 rhabdomere development;GO:0072499 photoreceptor cell axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9V6K3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V6X7-1", "uniprot_id": [ { "id": "OFUT1_DROME", "url": "https://www.uniprot.org/uniprot/Q9V6X7", "type": "external" } ], "mass": 46834.0, "length": 402, "protein_name": "GDP-fucose protein O-fucosyltransferase 1", "gene_name": "Ofut1", "organism": "Fruit fly", "refseq_name": "O-fucosyltransferase 1, isoform B", "refseq_ac": [ { "id": "NP_001286406", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286406", "type": "external" } ], "gene_names_uniprotkb": "Ofut1; CG12366; O-fut1; nti", "gene_names_refseq": "4R6; AAF58290.1; CG12366; Dmel\\CG12366; O-FUT1; O-fut1; O-fut; OFUT-1; OFUT1; OFut1; Ofut-1; Ofut1; l(2)SH2 2260; l(2)SH2260; ntc; nti; o-fut1", "protein_names_uniprotkb": "GDP-fucose protein O-fucosyltransferase 1; 2.4.1.221; Neurotic protein; O-FucT-1; Peptide-O-fucosyltransferase 1", "protein_names_refseq": "CG12366-PB; O-fucosyl transferase; O-fucosyltransferase 1, isoform B; O-fucosyltransferase; O-fut1-PB; neurotic; protein O-fucosyltransferase 1", "tax_id": 7227, "disease": "Dowling-Degos disease (Disease Ontology:DOID:0060256)", "pathway": " (dme:Dmel_CG12366)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10731132;11524432;11698403;12537569;12537572;12909620;12917292;15692013;17329366;18194540", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines (PubMed:12909620, PubMed:15692013). Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer (By similarity). Plays a crucial role in Notch signaling (PubMed:12909620, PubMed:12917292, PubMed:17329366). Initial fucosylation of N/Notch by Ofut1 generates a substrate for Fng/Fringe, an acetylglucosaminyltransferase that can then extend the fucosylation on the Notch EGF repeats (PubMed:12909620). This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by Delta/Dl or Ser/Serrate (PubMed:12909620, PubMed:12917292). Required for transport of N/Notch to the early endosome and to the apical membrane cell surface (PubMed:15692013, PubMed:17329366, PubMed:18194540). Facilitates secretion of N/Notch and may function as a chaperone independent of its fucosyltransferase activity (PubMed:15692013, PubMed:18194540). Fucosyltransferase activity is dispensible for embryonic developmental processes including neurogenesis (PubMed:18194540). Involved in Notch signaling during wing imaginal disc development (PubMed:18194540)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5BIC9;Q86SA7;Q8MSR1", "ec_number_list": [ { "id": "2.4.1.221", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.221", "type": "external" } ], "go_molecular_function": "GO:0046922 peptide-O-fucosyltransferase activity;GO:0005112 Notch binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:2000010 positive regulation of protein localization to cell surface;GO:0045747 positive regulation of Notch signaling pathway;GO:0045807 positive regulation of endocytosis;GO:0036066 protein O-linked glycosylation via fucose", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9V6X7-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V6Y3-1", "uniprot_id": [ { "id": "RT16_DROME", "url": "https://www.uniprot.org/uniprot/Q9V6Y3", "type": "external" } ], "mass": 14519.0, "length": 129, "protein_name": "Small ribosomal subunit protein bS16m", "gene_name": "mRpS16", "organism": "Fruit fly", "refseq_name": "mitochondrial ribosomal protein S16", "refseq_ac": [ { "id": "NP_523737", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523737", "type": "external" } ], "gene_names_uniprotkb": "mRpS16; CG8338", "gene_names_refseq": "147189_at; BcDNA:SD15809; CG8338; Dmel\\CG8338; MRP-S16; MRPS16; mRpS16", "protein_names_uniprotkb": "Small ribosomal subunit protein bS16m; 28S ribosomal protein S16, mitochondrial; MRP-S16; S16mt", "protein_names_refseq": "CG8338-PA; mRpS16-PA; mitochondrial ribosomal protein S16", "tax_id": 7227, "disease": "combined oxidative phosphorylation deficiency 2 (Disease Ontology:DOID:0111483)", "pathway": " (dme:Dmel_CG8338); (R-DME-5389840); (R-DME-5419276); (R-DME-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9V6Y3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V719-1", "uniprot_id": [ { "id": "SIN1_DROME", "url": "https://www.uniprot.org/uniprot/Q9V719", "type": "external" } ], "mass": 64239.0, "length": 569, "protein_name": "Stress-activated map kinase-interacting protein 1", "gene_name": "Sin1", "organism": "Fruit fly", "refseq_name": "SAPK-interacting protein 1", "refseq_ac": [ { "id": "NP_610963", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610963", "type": "external" } ], "gene_names_uniprotkb": "Sin1; CG10105", "gene_names_refseq": "CG10105; Dmel\\CG10105; SIN1; Sin1; dSIN1; dSin1; sin1", "protein_names_uniprotkb": "Stress-activated map kinase-interacting protein 1; SAPK-interacting protein 1; dSin1", "protein_names_refseq": "CG10105-PA; SAPK-interacting protein 1; Sin1-PA; Stress-activated protein kinase [SAPK]-interacting protein; stress-activated map kinase-interacting protein 1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10105); (R-DME-1257604); (R-DME-389357); (R-DME-5218920); (R-DME-9856530)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;16919458;17043309;18327897", "class_list": "", "function": "Component of the target of rapamycin complex 2 (TORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization and anabolic output (PubMed:16919458, PubMed:17043309). In response to growth factors, TORC2 phosphorylates and activates AGC protein kinase family members, such as Akt1 (PubMed:16919458, PubMed:17043309). Within the TORC2 complex, Sin1 acts as a substrate adapter which recognizes and binds AGC protein kinase family members for phosphorylation by mTor (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q53YG4", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0019901 protein kinase binding;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031932 TORC2 complex", "go_biological_process": "GO:0032869 cellular response to insulin stimulus;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0006915 apoptotic process;GO:0048813 dendrite morphogenesis;GO:0046628 positive regulation of insulin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9V719-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V784-1", "uniprot_id": [ { "id": "SAM50_DROME", "url": "https://www.uniprot.org/uniprot/Q9V784", "type": "external" } ], "mass": 49059.0, "length": 443, "protein_name": "SAM50-like protein CG7639", "gene_name": "CG7639", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_995838", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_995838", "type": "external" } ], "gene_names_uniprotkb": "CG7639", "gene_names_refseq": "CG7639; Dmel\\CG7639", "protein_names_uniprotkb": "SAM50-like protein CG7639", "protein_names_refseq": "CG7639-PB; uncharacterized protein", "tax_id": 7227, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208)", "pathway": " (dme:Dmel_CG7639)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "May play a role in the maintenance of the structure of mitochondrial cristae., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8STA1", "ec_number_list": [], "go_molecular_function": "GO:0032977 membrane insertase activity;GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:0001401 SAM complex;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0045040 protein insertion into mitochondrial outer membrane;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9V784-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V7U0-1", "uniprot_id": [ { "id": "RESIL_DROME", "url": "https://www.uniprot.org/uniprot/Q9V7U0", "type": "external" } ], "mass": 58604.0, "length": 620, "protein_name": "Pro-resilin", "gene_name": "resilin", "organism": "Fruit fly", "refseq_name": "resilin, isoform A", "refseq_ac": [ { "id": "NP_611157", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611157", "type": "external" } ], "gene_names_uniprotkb": "resilin; CG15920", "gene_names_refseq": "CG15920; Dmel\\CG15920; Resilin; resilin", "protein_names_uniprotkb": "Pro-resilin", "protein_names_refseq": "CG15920-PA; resilin, isoform A; resilin-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15920)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;11483432;12537572;16222249", "class_list": "", "function": "Plays a central role in insect flight by providing low stiffness, high strain and efficient energy storage., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q86P83", "ec_number_list": [], "go_molecular_function": "GO:0008061 chitin binding;GO:0030023 extracellular matrix constituent conferring elasticity;GO:0008010 structural constituent of chitin-based larval cuticle;GO:0042302 structural constituent of cuticle", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0032992 protein-carbohydrate complex;GO:0062129 chitin-based extracellular matrix", "go_biological_process": "GO:0040003 chitin-based cuticle development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9V7U0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V8W3-1", "uniprot_id": [ { "id": "RABEP_DROME", "url": "https://www.uniprot.org/uniprot/Q9V8W3", "type": "external" } ], "mass": 56827.0, "length": 511, "protein_name": "Rab proteins geranylgeranyltransferase component A", "gene_name": "Rep", "organism": "Fruit fly", "refseq_name": "Rab escort protein", "refseq_ac": [ { "id": "NP_477420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477420", "type": "external" } ], "gene_names_uniprotkb": "Rep; CG8432", "gene_names_refseq": "CG8432; Dmel\\CG8432; REP; Rep; rep", "protein_names_uniprotkb": "Rab proteins geranylgeranyltransferase component A; REP; Rab escort protein homolog", "protein_names_refseq": "CG8432-PA; Rab escort protein homolog; Rab escort protein; Rep-PA", "tax_id": 7227, "disease": "asthma (Disease Ontology:DOID:2841); choroideremia (Disease Ontology:DOID:9821)", "pathway": " (dme:Dmel_CG8432); (R-DME-6803205); (R-DME-8873719); (R-DME-8876198)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "10082978;10731132;12537569;12537572", "class_list": "", "function": "Binds unprenylated Rab proteins, presents it to the catalytic component B, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab to a protein acceptor (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O97142", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005092 GDP-dissociation inhibitor activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006612 protein targeting to membrane;GO:0007264 small GTPase-mediated signal transduction;GO:0016192 vesicle-mediated transport;GO:0007269 neurotransmitter secretion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9V8W3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V8Y2-1", "uniprot_id": [ { "id": "OB56A_DROME", "url": "https://www.uniprot.org/uniprot/Q9V8Y2", "type": "external" } ], "mass": 15403.0, "length": 139, "protein_name": "General odorant-binding protein 56a", "gene_name": "Obp56a", "organism": "Fruit fly", "refseq_name": "Odorant-binding protein 56a", "refseq_ac": [ { "id": "NP_611442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611442", "type": "external" } ], "gene_names_uniprotkb": "Obp56a; CG11797", "gene_names_refseq": "56a; BcDNA:RE46170; CG11797; DmelObp56a; Dmel\\CG11797; OBP56a; Obp56a; obp56a", "protein_names_uniprotkb": "General odorant-binding protein 56a", "protein_names_refseq": "CG11797-PA; Obp56a-PA; Odorant-binding protein 56a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11797)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;11729153;12505997;12537569;12537572;17720903", "class_list": "", "function": "Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A9QH77;A9QH80;A9QH86;A9QH94;A9QHB8", "ec_number_list": [], "go_molecular_function": "GO:0005549 odorant binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0042048 olfactory behavior;GO:0007608 sensory perception of smell;GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9V8Y2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V8Y7-1", "uniprot_id": [ { "id": "OR56A_DROME", "url": "https://www.uniprot.org/uniprot/Q9V8Y7", "type": "external" } ], "mass": 48920.0, "length": 419, "protein_name": "Odorant receptor 56a", "gene_name": "Or56a", "organism": "Fruit fly", "refseq_name": "odorant receptor 56a", "refseq_ac": [ { "id": "NP_523796", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523796", "type": "external" } ], "gene_names_uniprotkb": "Or56a; CG12501", "gene_names_refseq": "56E.1; 56a; CG12501; DOR59; DmOr56a; Dmel\\CG12501; OR56a; Or-56a; Or56a", "protein_names_uniprotkb": "Odorant receptor 56a", "protein_names_refseq": "CG12501-PA; Or56a-PA; odorant receptor 56a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12501)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;10943836;12537572;23217715", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Specific receptor for geosmin, a microbial odorant that constitutes an ecologically relevant stimulus that alerts flies to the presence of harmful microbes and induces avoidance behavior., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9V8Y7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V931-1", "uniprot_id": [ { "id": "OB57C_DROME", "url": "https://www.uniprot.org/uniprot/Q9V931", "type": "external" } ], "mass": 17223.0, "length": 149, "protein_name": "General odorant-binding protein 57c", "gene_name": "Obp57c", "organism": "Fruit fly", "refseq_name": "Odorant-binding protein 57c", "refseq_ac": [ { "id": "NP_611481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611481", "type": "external" } ], "gene_names_uniprotkb": "Obp57c; CG13421", "gene_names_refseq": "57c; BcDNA:RH68952; CG13421; DmelObp57c; Dmel\\CG13421; OBP57c; Obp57a; Obp57c; obp57c", "protein_names_uniprotkb": "General odorant-binding protein 57c", "protein_names_refseq": "CG13421-PA; Obp57c-PA; Odorant-binding protein 57c", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13421)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12119098;12213773;12537569;12537572", "class_list": "", "function": "Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8DYJ8;Q4V3N2", "ec_number_list": [], "go_molecular_function": "GO:0005549 odorant binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007608 sensory perception of smell;GO:0007606 sensory perception of chemical stimulus;GO:1990834 response to odorant", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9V931-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V938-1", "uniprot_id": [ { "id": "OB57E_DROME", "url": "https://www.uniprot.org/uniprot/Q9V938", "type": "external" } ], "mass": 15552.0, "length": 136, "protein_name": "General odorant-binding protein 57e", "gene_name": "Obp57e", "organism": "Fruit fly", "refseq_name": "Odorant-binding protein 57e", "refseq_ac": [ { "id": "NP_611488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611488", "type": "external" } ], "gene_names_uniprotkb": "Obp57e; CG30145", "gene_names_refseq": "57e; CG13429; CG30145; DmelObp57e; Dmel\\CG30145; Dmel\\Obp57e; OBP57e; Obp57d; Obp57e", "protein_names_uniprotkb": "General odorant-binding protein 57e", "protein_names_refseq": "CG30145-PA; Obp57e-PA; Odorant-binding protein 57e", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG30145)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12119098;12213773;12537572", "class_list": "", "function": "Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5KS09;Q5KS33", "ec_number_list": [], "go_molecular_function": "GO:0005549 odorant binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007608 sensory perception of smell;GO:0007606 sensory perception of chemical stimulus;GO:1990834 response to odorant", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9V938-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V9A7-1", "uniprot_id": [ { "id": "MCCB_DROME", "url": "https://www.uniprot.org/uniprot/Q9V9A7", "type": "external" } ], "mass": 62648.0, "length": 578, "protein_name": "Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial", "gene_name": "Mccc2", "organism": "Fruit fly", "refseq_name": "Methylcrotonoyl-CoA carboxylase 2", "refseq_ac": [ { "id": "NP_652724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_652724", "type": "external" } ], "gene_names_uniprotkb": "Mccc2; CG3267; l(2)04524", "gene_names_refseq": "CG3267; Dmel\\CG3267; FBgn0042083; MCCC2_DROME; Mccc2; l(2)4524", "protein_names_uniprotkb": "Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; 3-methylcrotonyl-CoA carboxylase 2; 3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta; 6.4.1.4; MCCase subunit beta", "protein_names_refseq": "CG3267-PA; Mccc2-PA; Methylcrotonoyl-CoA carboxylase 2", "tax_id": 7227, "disease": "3-methylcrotonyl-CoA carboxylase 2 deficiency (Disease Ontology:DOID:0080580); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (dme:Dmel_CG3267); (R-DME-196780); (R-DME-70895)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;9584098", "class_list": "", "function": "Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism (By similarity). Vital for adult survival., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O18364;Q8SXT5", "ec_number_list": [ { "id": "6.3.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.-", "type": "external" }, { "id": "6.3.4.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.15", "type": "external" }, { "id": "6.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.1", "type": "external" }, { "id": "6.4.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.4", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004485 methylcrotonoyl-CoA carboxylase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:1905202 methylcrotonoyl-CoA carboxylase complex", "go_biological_process": "GO:0006552 L-leucine catabolic process;GO:0007563 regulation of eclosion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9V9A7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V9I2-1", "uniprot_id": [ { "id": "OR42A_DROME", "url": "https://www.uniprot.org/uniprot/Q9V9I2", "type": "external" } ], "mass": 46917.0, "length": 406, "protein_name": "Odorant receptor 42a", "gene_name": "Or42a", "organism": "Fruit fly", "refseq_name": "odorant receptor 42a", "refseq_ac": [ { "id": "NP_523622", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523622", "type": "external" } ], "gene_names_uniprotkb": "Or42a; CG17250", "gene_names_refseq": "41E.2; 42a; CG17250; DOR117; Dmel\\CG17250; OR42a; Or42A; Or42a", "protein_names_uniprotkb": "Odorant receptor 42a", "protein_names_refseq": "CG17250-PA; Or42a-PA; odorant receptor 42a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17250)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;21613503;21857978", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to butanol, ethyl acetate, propyl acetate, and pentyl acetate. Also responds to pyrazines., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q29QF3", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0042048 olfactory behavior;GO:0007165 signal transduction;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9V9I2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V9S8-1", "uniprot_id": [ { "id": "HEMH_DROME", "url": "https://www.uniprot.org/uniprot/Q9V9S8", "type": "external" } ], "mass": 43597.0, "length": 384, "protein_name": "Ferrochelatase, mitochondrial", "gene_name": "FeCh", "organism": "Fruit fly", "refseq_name": "ferrochelatase, isoform A", "refseq_ac": [ { "id": "NP_524613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524613", "type": "external" } ], "gene_names_uniprotkb": "FeCh; CG2098", "gene_names_refseq": "CG2098; Dmel\\CG2098; FeCH; ferrochelatase", "protein_names_uniprotkb": "Ferrochelatase, mitochondrial; 4.98.1.1; Heme synthase; Protoheme ferro-lyase", "protein_names_refseq": "CG2098-PA; FeCH-PA; ferrochelatase, isoform A; ferrochelatase", "tax_id": 7227, "disease": "erythropoietic protoporphyria (Disease Ontology:DOID:13270); cutaneous porphyria (Disease Ontology:DOID:13271); cancer (Disease Ontology:DOID:162); colon adenocarcinoma (Disease Ontology:DOID:234)", "pathway": " (dme:Dmel_CG2098); (R-DME-189451); (R-DME-9837999)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;9712849", "class_list": "", "function": "Catalyzes the ferrous insertion into protoporphyrin IX (PubMed:9712849). Terminal enzyme in heme biosynthesis (PubMed:9712849). Contains four conserved cysteines that function as cluster ligands and play a crucial role in maintaining protein structure (PubMed:9712849)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O76533;Q8IGA4;Q8IH67;Q8IMF9;Q95U82", "ec_number_list": [ { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "1.1.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.40", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "1.1.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.39", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.51", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.-.-", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "2.3.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.16", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0004325 ferrochelatase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006783 heme biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9V9S8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V9Y4-1", "uniprot_id": [ { "id": "PHCL2_DROME", "url": "https://www.uniprot.org/uniprot/Q9V9Y4", "type": "external" } ], "mass": 59826.0, "length": 526, "protein_name": "pH-sensitive chloride channel 2", "gene_name": "pHCl-2", "organism": "Fruit fly", "refseq_name": "pH-sensitive chloride channel 2, isoform B", "refseq_ac": [ { "id": "NP_001303470", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303470", "type": "external" } ], "gene_names_uniprotkb": "pHCl-2; CG11340; hodor", "gene_names_refseq": "CG11340; CT5896; Dmel\\CG11340; Lcch-100C; hodor; lincRNA.914; pHCL-2; pHCl-2", "protein_names_uniprotkb": "pH-sensitive chloride channel 2; Ligand-gated chloride channel protein hodor", "protein_names_refseq": "CG11340-PB; glycine-gated chloride channel-like; hold on, don't rush; pH-sensitive chloride channel 2, isoform B; pHCl-2-PB", "tax_id": 7227, "disease": "cocaine abuse (Disease Ontology:DOID:809)", "pathway": " (dme:Dmel_CG11340); (R-DME-112314)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;12537572;27172217;27358471;32269334", "class_list": "", "function": "Ligand and pH-gated channel that mediates chloride transport primarily in the mid-gut and thereby functions in larval metabolism and fluid homeostasis (PubMed:27172217, PubMed:27358471, PubMed:32269334). Channel opening is triggered by zinc binding or, to a lesser extent, an increase in extracellular pH (PubMed:27358471, PubMed:32269334). Zinc-dependent activity in the mid-gut is required for modulating Tor-dependent metabolic programs that promote larval feeding and systematic growth (PubMed:32269334). It may therefore act as an intestinal zinc sensor that mediates larval growth and metabolism in response to micronutrient availability (PubMed:32269334). Activates Tor signaling via its activity in maintaining lysosome homeostasis in interstitial cells and/or by its role in activating the release of insulin-like peptides in the brain after feeding, via an unknown mechanism (PubMed:32269334). Functions in lysosome homeostasis by regulating chloride transport into enterocyte lysosomes to sustain V-ATPase function which maintains lysosomal acidification and consequently promotes Tor activation at the lysosome membrane (PubMed:32269334). Also appears to play a role in regulating fluid secretion and osmotic homeostasis in Malpighian tubules in response to the pH of extracellular urine (PubMed:27358471). This function is important for proper urine production during diuresis (PubMed:27358471)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "E3CTP9", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0005254 chloride channel activity;GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity;GO:0061797 pH-gated chloride channel activity;GO:0106219 zinc ion sensor activity", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0016324 apical plasma membrane;GO:0031902 late endosome membrane;GO:0098794 postsynapse;GO:0031526 brush border membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:1902476 chloride transmembrane transport;GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway;GO:0071294 cellular response to zinc ion;GO:2001151 regulation of renal water transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9V9Y4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VAC8-1", "uniprot_id": [ { "id": "SAS6_DROME", "url": "https://www.uniprot.org/uniprot/Q9VAC8", "type": "external" } ], "mass": 54769.0, "length": 472, "protein_name": "Spindle assembly abnormal protein 6 homolog", "gene_name": "Sas-6", "organism": "Fruit fly", "refseq_name": "spindle assembly abnormal 6", "refseq_ac": [ { "id": "NP_651756", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651756", "type": "external" } ], "gene_names_uniprotkb": "Sas-6; CG15524; SAS6", "gene_names_refseq": "CG15524; DSAS-6; DSas-6; DSas6; Dmel\\CG15524; Dsas6; SAS-6; SAS6; Sas-6; Sas6; dsas-6; sas-6; sas6", "protein_names_uniprotkb": "Spindle assembly abnormal protein 6 homolog", "protein_names_refseq": "CG15524-PA; Sas-6-PA; spindle assembly abnormal 6 ortholog; spindle assembly abnormal 6", "tax_id": 7227, "disease": "primary autosomal recessive microcephaly 14 (Disease Ontology:DOID:0070279)", "pathway": " (dme:Dmel_CG15524)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10731132;12537569;12537572;17412918;17463247;29892014;30013109;33704067", "class_list": "", "function": "Central scaffolding component of the centrioles ensuring their 9-fold symmetry (PubMed:17412918, PubMed:17463247, PubMed:30013109). Required for centrosome biogenesis and duplication (PubMed:17412918, PubMed:17463247, PubMed:30013109, PubMed:33704067). In ciliated neurons, required for centriole assembly but not necessary for cilium basal body and cilia function (PubMed:30013109). Required for sperm cilium basal body elongation together with Cep135 and Ana2 (PubMed:30013109)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8T8U6;S0ASJ5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0007098 centrosome cycle;GO:0051298 centrosome duplication;GO:0071539 protein localization to centrosome;GO:0010457 centriole-centriole cohesion;GO:0098534 centriole assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9VAC8-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VAJ3-1", "uniprot_id": [ { "id": "PPK19_DROME", "url": "https://www.uniprot.org/uniprot/Q9VAJ3", "type": "external" } ], "mass": 59461.0, "length": 511, "protein_name": "Pickpocket protein 19", "gene_name": "ppk19", "organism": "Fruit fly", "refseq_name": "pickpocket 19", "refseq_ac": [ { "id": "NP_651708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651708", "type": "external" } ], "gene_names_uniprotkb": "ppk19; CG18287", "gene_names_refseq": "CG18287; Dmel\\CG18287; PPK19; Ppk19; ppk19", "protein_names_uniprotkb": "Pickpocket protein 19; PPK19", "protein_names_refseq": "CG18287-PA; Pickpocket19; pickpocket 19; ppk19-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18287)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;12571352;12848938", "class_list": "", "function": "Part of a complex that plays a role in tracheal liquid clearance. In both larvae and adults, contributes to the behavioral response to salt. Probable role in sodium transport., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q86LG6", "ec_number_list": [], "go_molecular_function": "GO:0005272 sodium channel activity;GO:0140135 mechanosensitive monoatomic cation channel activity;GO:0160128 pH-gated monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0034706 sodium channel complex", "go_biological_process": "GO:0050966 detection of mechanical stimulus involved in sensory perception of pain;GO:0009651 response to salt stress;GO:0035725 sodium ion transmembrane transport;GO:0050968 detection of chemical stimulus involved in sensory perception of pain;GO:0035002 liquid clearance, open tracheal system", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VAJ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VAQ7-1", "uniprot_id": [ { "id": "SLU7_DROME", "url": "https://www.uniprot.org/uniprot/Q9VAQ7", "type": "external" } ], "mass": 65978.0, "length": 574, "protein_name": "Pre-mRNA-splicing factor Slu7", "gene_name": "Slu7", "organism": "Fruit fly", "refseq_name": "Slu7", "refseq_ac": [ { "id": "NP_651659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651659", "type": "external" } ], "gene_names_uniprotkb": "Slu7; CG1420", "gene_names_refseq": "CG1420; Dmel\\CG1420; SLU7; Slu7", "protein_names_uniprotkb": "Pre-mRNA-splicing factor Slu7", "protein_names_refseq": "CG1420-PA; Slu7-PA; Slu7", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1420); (R-DME-159236); (R-DME-72163)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10731132;10908584;12537569;12537572;18327897", "class_list": "", "function": "Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95RD1", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030628 pre-mRNA 3'-splice site binding;GO:0000386 second spliceosomal transesterification activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0045292 mRNA cis splicing, via spliceosome;GO:0000389 mRNA 3'-splice site recognition", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VAQ7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VAW0-1", "uniprot_id": [ { "id": "OR98B_DROME", "url": "https://www.uniprot.org/uniprot/Q9VAW0", "type": "external" } ], "mass": 43644.0, "length": 384, "protein_name": "Putative odorant receptor 98b", "gene_name": "Or98b", "organism": "Fruit fly", "refseq_name": "odorant receptor 98b", "refseq_ac": [ { "id": "NP_524540", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524540", "type": "external" } ], "gene_names_uniprotkb": "Or98b; CG1867", "gene_names_refseq": "98C.1; 98b; CG1867; DOR121; Dmel\\CG1867; Or98bP; Or98b; or98b", "protein_names_uniprotkb": "Putative odorant receptor 98b", "protein_names_refseq": "CG1867-PB; Or98b-PB; odorant receptor 98b", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1867)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VAW0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VAZ3-1", "uniprot_id": [ { "id": "OR98A_DROME", "url": "https://www.uniprot.org/uniprot/Q9VAZ3", "type": "external" } ], "mass": 45437.0, "length": 397, "protein_name": "Odorant receptor 98a", "gene_name": "Or98a", "organism": "Fruit fly", "refseq_name": "odorant receptor 98a", "refseq_ac": [ { "id": "NP_524536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524536", "type": "external" } ], "gene_names_uniprotkb": "Or98a; CG5540", "gene_names_refseq": "98B.1; 98a; CG5540; DOR110; DmOr98a; Dmel\\CG5540; OR98a; Or-98a; Or98A; Or98a", "protein_names_uniprotkb": "Odorant receptor 98a", "protein_names_refseq": "CG5540-PA; Or98a-PA; odorant receptor 98a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5540)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;10943836;12537572;16615896", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0099604 ligand-gated calcium channel activity;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0070588 calcium ion transmembrane transport;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VAZ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VB68-1", "uniprot_id": [ { "id": "GRASS_DROME", "url": "https://www.uniprot.org/uniprot/Q9VB68", "type": "external" } ], "mass": 41511.0, "length": 377, "protein_name": "Serine protease grass", "gene_name": "grass", "organism": "Fruit fly", "refseq_name": "Gram-positive specific serine protease, isoform B", "refseq_ac": [ { "id": "NP_651543", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651543", "type": "external" } ], "gene_names_uniprotkb": "grass; CG5896; c-SP1", "gene_names_refseq": "CG5896; Dmel\\CG5896; Grass; SP1; SP2; c-SP1; cSP1; grass", "protein_names_uniprotkb": "Serine protease grass; 3.4.21.-; Gram-positive specific serine protease", "protein_names_refseq": "CG5896-PB; Gram-positive specific serine protease, isoform B; Gram-positive-specific serine protease; gram-positive specific serine protease; grass-PB; herrade", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5896)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;16631589;18724373;21310954", "class_list": "", "function": "Endopeptidase (By similarity). Plays a key role in innate immunity by activating the Toll pathway in response to fungal and Gram-positive bacterial infections, presumably downstream of pattern-recognition receptors (PRR), such as PGRP-SA, GNBP1 and GNBP3, and upstream of spz processing enzyme SPE (PubMed:16631589, PubMed:18724373)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q86PB3;Q8MR95;Q9VB67", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding;GO:0017171 serine hydrolase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0045087 innate immune response;GO:0050830 defense response to Gram-positive bacterium;GO:0050832 defense response to fungus;GO:0006963 positive regulation of antibacterial peptide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9VB68-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VBI0-1", "uniprot_id": [ { "id": "Q9VBI0_DROME", "url": "https://www.uniprot.org/uniprot/Q9VBI0", "type": "external" } ], "mass": 22466.0, "length": 195, "protein_name": "Pre-rRNA-processing protein TSR2 homolog", "gene_name": "Dmel\\CG14543", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_651458", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651458", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG14543; CG14543; Dmel_CG14543", "gene_names_refseq": "CG14543; Dmel\\CG14543", "protein_names_uniprotkb": "Pre-rRNA-processing protein TSR2 homolog", "protein_names_refseq": "CG14543-PA; uncharacterized protein", "tax_id": 7227, "disease": "Diamond-Blackfan anemia 14 with mandibulofacial dysostosis (Disease Ontology:DOID:0111897)", "pathway": " (dme:Dmel_CG14543)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "May be involved in 20S pre-rRNA processing., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VBI0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VBI1-1", "uniprot_id": [ { "id": "Q9VBI1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VBI1", "type": "external" } ], "mass": 26125.0, "length": 228, "protein_name": "DNA replication complex GINS protein SLD5", "gene_name": "Sld5", "organism": "Fruit fly", "refseq_name": "Sld5", "refseq_ac": [ { "id": "NP_651457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651457", "type": "external" } ], "gene_names_uniprotkb": "Sld5; CG14549; Dmel\\CG14549; Dmel_CG14549; SLD5; anon-WO0172774.61", "gene_names_refseq": "CG14549; Dmel\\CG14549; SLD5; Sld5; anon-WO0172774.61", "protein_names_uniprotkb": "DNA replication complex GINS protein SLD5", "protein_names_refseq": "CG14549-PA; Sld5-PA; Sld5", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14549); (R-DME-176974)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;31484077", "class_list": "", "function": "The GINS complex plays an essential role in the initiation of DNA replication., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0000811 GINS complex;GO:0071162 CMG complex", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006260 DNA replication;GO:0006270 DNA replication initiation;GO:0000727 double-strand break repair via break-induced replication", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VBI1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VBN7-2", "uniprot_id": [ { "id": "SAMC_DROME", "url": "https://www.uniprot.org/uniprot/Q9VBN7", "type": "external" } ], "mass": 32275.0, "length": 297, "protein_name": "S-adenosylmethionine mitochondrial carrier protein homolog", "gene_name": "CG4743", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_651415", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651415", "type": "external" } ], "gene_names_uniprotkb": "CG4743", "gene_names_refseq": "CG4743; Dmel\\CG4743; Samc", "protein_names_uniprotkb": "S-adenosylmethionine mitochondrial carrier protein homolog", "protein_names_refseq": "CG4743-PA; uncharacterized protein", "tax_id": 7227, "disease": "combined oxidative phosphorylation deficiency 28 (Disease Ontology:DOID:0111470)", "pathway": " (dme:Dmel_CG4743); (R-DME-549127)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537572;27313316", "class_list": "", "function": "Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May mediate the transport of S-adenosylmethionine (SAM) into the mitochondria (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4V4S1", "ec_number_list": [], "go_molecular_function": "GO:0000095 S-adenosyl-L-methionine transmembrane transporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0015805 S-adenosyl-L-methionine transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VBN7-2", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VBQ9-1", "uniprot_id": [ { "id": "MED28_DROME", "url": "https://www.uniprot.org/uniprot/Q9VBQ9", "type": "external" } ], "mass": 21079.0, "length": 189, "protein_name": "Mediator of RNA polymerase II transcription subunit 28", "gene_name": "MED28", "organism": "Fruit fly", "refseq_name": "mediator complex subunit 28", "refseq_ac": [ { "id": "NP_651397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651397", "type": "external" } ], "gene_names_uniprotkb": "MED28; CG5121; Med23", "gene_names_refseq": "BcDNA:GM31575; CG5121; Dmel\\CG5121; MED28; Med23; Med28; dMED23", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 28; Mediator complex subunit 28; dMED23", "protein_names_refseq": "CG5121-PA; MED28-PA; mediator complex subunit 28", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5121)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12021283;12537569;12537572", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016592 mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VBQ9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VBV5-1", "uniprot_id": [ { "id": "SIL1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VBV5", "type": "external" } ], "mass": 47943.0, "length": 429, "protein_name": "Nucleotide exchange factor Sil1", "gene_name": "Sil1", "organism": "Fruit fly", "refseq_name": "Sil1 nucleotide exchange factor", "refseq_ac": [ { "id": "NP_651356", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651356", "type": "external" } ], "gene_names_uniprotkb": "Sil1; CG10420", "gene_names_refseq": "CG10420; Dmel\\CG10420; SIL1; Sil1", "protein_names_uniprotkb": "Nucleotide exchange factor Sil1", "protein_names_refseq": "CG10420-PA; Sil1 nucleotide exchange factor; Sil1-PA", "tax_id": 7227, "disease": "Marinesco-Sjogren syndrome (Disease Ontology:DOID:0080195); primary cerebellar degeneration (Disease Ontology:DOID:9277)", "pathway": " (dme:Dmel_CG10420)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for an ER lumenal chaperone of HSP70 family (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000774 adenyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0012505 endomembrane system", "go_biological_process": "GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VBV5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VCA5-1", "uniprot_id": [ { "id": "SYFB_DROME", "url": "https://www.uniprot.org/uniprot/Q9VCA5", "type": "external" } ], "mass": 65778.0, "length": 589, "protein_name": "Phenylalanine--tRNA ligase beta subunit", "gene_name": "beta-PheRS", "organism": "Fruit fly", "refseq_name": "Phenylalanyl-tRNA synthetase, beta-subunit", "refseq_ac": [ { "id": "NP_651237", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651237", "type": "external" } ], "gene_names_uniprotkb": "beta-PheRS; CG5706", "gene_names_refseq": "CG5706; Dmel\\CG5706; beta-PheRS", "protein_names_uniprotkb": "Phenylalanine--tRNA ligase beta subunit; 6.1.1.20; PheRS; Phenylalanyl-tRNA synthetase beta subunit", "protein_names_refseq": "CG5706-PA; Phenylalanyl-tRNA synthetase beta subunit; Phenylalanyl-tRNA synthetase, beta-subunit; beta-PheRS-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5706)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;25427601", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.20", "type": "external" } ], "go_molecular_function": "GO:0002161 aminoacyl-tRNA deacylase activity;GO:0000287 magnesium ion binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0004826 phenylalanine-tRNA ligase activity", "go_cellular_component": "GO:0009328 phenylalanine-tRNA ligase complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006432 phenylalanyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VCA5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VCG2-1", "uniprot_id": [ { "id": "OPA31_DROME", "url": "https://www.uniprot.org/uniprot/Q9VCG2", "type": "external" } ], "mass": 17685.0, "length": 153, "protein_name": "Putative OPA3-like protein CG43998", "gene_name": "CG43998", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001287491", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287491", "type": "external" } ], "gene_names_uniprotkb": "CG43998", "gene_names_refseq": "BcDNA:AT03227; CG13602; CG43998; CR43998; Dmel\\CG43998", "protein_names_uniprotkb": "Putative OPA3-like protein CG43998", "protein_names_refseq": "CG43998-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "3-methylglutaconic aciduria type 3 (Disease Ontology:DOID:0110004); optic atrophy 3 (Disease Ontology:DOID:0111433)", "pathway": " (dme:Dmel_CG43998)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4LHM8;Q8T4I9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0019216 regulation of lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VCG2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VCS9-1", "uniprot_id": [ { "id": "OR94A_DROME", "url": "https://www.uniprot.org/uniprot/Q9VCS9", "type": "external" } ], "mass": 46052.0, "length": 387, "protein_name": "Odorant receptor 94a", "gene_name": "Or94a", "organism": "Fruit fly", "refseq_name": "odorant receptor 94a", "refseq_ac": [ { "id": "NP_524455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524455", "type": "external" } ], "gene_names_uniprotkb": "Or94a; CG17241", "gene_names_refseq": "94D.1; 94a; CG17241; DOR108; Dmel\\CG17241; Or94a", "protein_names_uniprotkb": "Odorant receptor 94a", "protein_names_refseq": "CG17241-PA; Or94a-PA; odorant receptor 94a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17241)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;21613503", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VCS9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VCU5-1", "uniprot_id": [ { "id": "MTG1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VCU5", "type": "external" } ], "mass": 36545.0, "length": 323, "protein_name": "Mitochondrial ribosome-associated GTPase 1", "gene_name": "CG17141", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_651094", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651094", "type": "external" } ], "gene_names_uniprotkb": "CG17141", "gene_names_refseq": "CG17141; Dmel\\CG17141", "protein_names_uniprotkb": "Mitochondrial ribosome-associated GTPase 1; Mitochondrial GTPase 1", "protein_names_refseq": "CG17141-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17141)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;18327897", "class_list": "", "function": "Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity (By similarity). Displays mitochondrial GTPase activity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V5C0", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0070129 regulation of mitochondrial translation;GO:1902775 mitochondrial large ribosomal subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VCU5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VCX3-1", "uniprot_id": [ { "id": "RM45_DROME", "url": "https://www.uniprot.org/uniprot/Q9VCX3", "type": "external" } ], "mass": 41611.0, "length": 361, "protein_name": "Large ribosomal subunit protein mL45", "gene_name": "mRpL45", "organism": "Fruit fly", "refseq_name": "mitochondrial ribosomal protein L45", "refseq_ac": [ { "id": "NP_651072", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651072", "type": "external" } ], "gene_names_uniprotkb": "mRpL45; CG6949", "gene_names_refseq": "CG6949; Dmel\\CG6949; MRP-L45; XI-2; l(3)A8; l(3)SG61; l(3)dsl-8; l(3)dsl8; mRpL45", "protein_names_uniprotkb": "Large ribosomal subunit protein mL45; 39S ribosomal protein L45, mitochondrial; L45mt; MRP-L45", "protein_names_refseq": "CG6949-PA; lethal (3) SG61; mRpL45-PA; mitochondrial ribosomal protein L45; mitochondrial ribosomal protein large subunit 45", "tax_id": 7227, "disease": "atherosclerosis (Disease Ontology:DOID:1936)", "pathway": " (dme:Dmel_CG6949); (R-DME-5389840); (R-DME-5419276); (R-DME-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VCX3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VDD8-1", "uniprot_id": [ { "id": "Q9VDD8_DROME", "url": "https://www.uniprot.org/uniprot/Q9VDD8", "type": "external" } ], "mass": 102666.0, "length": 896, "protein_name": "Ubiquitin carboxyl-terminal hydrolase", "gene_name": "Usp8", "organism": "Fruit fly", "refseq_name": "ubiquitin specific protease 8, isoform A", "refseq_ac": [ { "id": "NP_650948", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650948", "type": "external" } ], "gene_names_uniprotkb": "Usp8; CG5798; CT18196; Dmel\\CG5798; Dmel_CG5798; Q9VDD8; UBPY; USP8; UbpY; Ubpy; dUBPY; ubpy; usp8", "gene_names_refseq": "CG5798; CT18196; Dmel\\CG5798; Q9VDD8; UBPY/USP8; UBPY; USP8; UbpY; Ubpy; Usp8; dUBPY; ubpy; usp8", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase; 3.4.19.12", "protein_names_refseq": "CG5798-PA; UBPY ortholog; Usp8-PA; ubiquitin specific protease 8, isoform A", "tax_id": 7227, "disease": "ACTH-secreting pituitary adenoma (Disease Ontology:DOID:7004)", "pathway": " (R-DME-1358803); (R-DME-5689880)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0006508 proteolysis;GO:0016322 neuron remodeling;GO:0016579 protein deubiquitination;GO:0007265 Ras protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VDD8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VDE5-1", "uniprot_id": [ { "id": "PPAN_DROME", "url": "https://www.uniprot.org/uniprot/Q9VDE5", "type": "external" } ], "mass": 53093.0, "length": 460, "protein_name": "Protein Peter pan", "gene_name": "ppan", "organism": "Fruit fly", "refseq_name": "peter pan", "refseq_ac": [ { "id": "NP_476979", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476979", "type": "external" } ], "gene_names_uniprotkb": "ppan; CG5786", "gene_names_refseq": "CG5786; Dmel\\CG5786; PPAN; Ppan; SSF1; l(3)02231; l(3)j6B6; ppan", "protein_names_uniprotkb": "Protein Peter pan", "protein_names_refseq": "CG5786-PA; peter pan; peterpan; ppan-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5786)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10359593;10731132;12537572;17372656;18327897", "class_list": "", "function": "Required for initiation of larval growth and normal mitotic growth but is not absolutely required for general biosynthesis or DNA replication. Required for progression of normal oogenesis and maturation of some imaginal tissues into adult structures., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O97133", "ec_number_list": [], "go_molecular_function": "GO:0019843 rRNA binding", "go_cellular_component": "GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0048477 oogenesis;GO:0007292 female gamete generation;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0002164 larval development;GO:0007444 imaginal disc development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VDE5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VDM1-1", "uniprot_id": [ { "id": "OR92A_DROME", "url": "https://www.uniprot.org/uniprot/Q9VDM1", "type": "external" } ], "mass": 47552.0, "length": 408, "protein_name": "Putative odorant receptor 92a", "gene_name": "Or92a", "organism": "Fruit fly", "refseq_name": "odorant receptor 92a", "refseq_ac": [ { "id": "NP_524414", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524414", "type": "external" } ], "gene_names_uniprotkb": "Or92a; CG17916", "gene_names_refseq": "92E.1; 92a; CG17916; DOR111; Dmel\\CG17916; OR 92a; OR92a; Or92A; Or92a", "protein_names_uniprotkb": "Putative odorant receptor 92a", "protein_names_refseq": "CG17916-PA; Or92a-PA; odorant receptor 92a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17916)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VDM1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VDZ3-1", "uniprot_id": [ { "id": "SQZ_DROME", "url": "https://www.uniprot.org/uniprot/Q9VDZ3", "type": "external" } ], "mass": 59549.0, "length": 535, "protein_name": "Zinc finger protein squeeze", "gene_name": "sqz", "organism": "Fruit fly", "refseq_name": "squeeze", "refseq_ac": [ { "id": "NP_524403", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524403", "type": "external" } ], "gene_names_uniprotkb": "sqz; CG5557", "gene_names_refseq": "CG5557; Dmel\\CG5557; SQZ; Sqz; anon-WO0118547.697; l(3)02102; sqz", "protein_names_uniprotkb": "Zinc finger protein squeeze", "protein_names_refseq": "CG5557-PA; squeeze; sqz-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5557)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537569;12537572;12679036;14568107;15748845;17276922;17372656;17428824;17442544;18327897", "class_list": "", "function": "Transcription factor involved in neuronal fate specification. First required in embryonic CNS development to define the number of cells that express apterous (ap) in the ap thoracic cluster of interneurons. Later on, it plays a central role in the combinatorial code of transcription factors that specifies the fate of the Tv neuron in the ap cluster by participating in the transcription regulation of FMRFa in Tv cells. Also required for projection neuron dendritic targeting., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MT44;Q9U9A8", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0048666 neuron development;GO:0014019 neuroblast development;GO:0070983 dendrite guidance", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VDZ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VDZ4-1", "uniprot_id": [ { "id": "NSUN5_DROME", "url": "https://www.uniprot.org/uniprot/Q9VDZ4", "type": "external" } ], "mass": 49280.0, "length": 433, "protein_name": "28S rRNA (cytosine-C(5))-methyltransferase", "gene_name": "Nsun5", "organism": "Fruit fly", "refseq_name": "Nop2/Sun-like domain containing protein 5", "refseq_ac": [ { "id": "NP_650787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650787", "type": "external" } ], "gene_names_uniprotkb": "Nsun5; CG42358", "gene_names_refseq": "CG42358; CG5558; Dmel\\CG42358; Nsun5; dNsun5", "protein_names_uniprotkb": "28S rRNA (cytosine-C(5))-methyltransferase; 2.1.1.-; NOL1/NOP2/Sun domain family member 5", "protein_names_refseq": "CG42358-PA; Nop2/Sun-like domain containing protein 5; Nsun5-PA", "tax_id": 7227, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (dme:Dmel_CG42358)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;25635753", "class_list": "", "function": "S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of a cytosine in 28S rRNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0045089 positive regulation of innate immune response;GO:0070475 rRNA base methylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VDZ4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VE04-1", "uniprot_id": [ { "id": "RM55_DROME", "url": "https://www.uniprot.org/uniprot/Q9VE04", "type": "external" } ], "mass": 12568.0, "length": 107, "protein_name": "Large ribosomal subunit protein mL55", "gene_name": "mRpL55", "organism": "Fruit fly", "refseq_name": "mitochondrial ribosomal protein L55", "refseq_ac": [ { "id": "NP_650780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650780", "type": "external" } ], "gene_names_uniprotkb": "mRpL55; CG14283", "gene_names_refseq": "BcDNA:RH10246; CG14283; Dmel\\CG14283; MRP-L55; mRpL55; tmb", "protein_names_uniprotkb": "Large ribosomal subunit protein mL55; 39S ribosomal protein L55, mitochondrial; L55mt; MRP-L55", "protein_names_refseq": "CG14283-PA; mRpL55-PA; mitochondrial ribosomal protein L55; tom thumb", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14283); (R-DME-5389840); (R-DME-5419276); (R-DME-9937383)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;15894314", "class_list": "", "function": "Involved in mitochondrial biogenesis and G2/M phase cell cycle progression., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VE04-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VE17-1", "uniprot_id": [ { "id": "RU1C_DROME", "url": "https://www.uniprot.org/uniprot/Q9VE17", "type": "external" } ], "mass": 15760.0, "length": 145, "protein_name": "U1 small nuclear ribonucleoprotein C", "gene_name": "snRNP-U1-C", "organism": "Fruit fly", "refseq_name": "small ribonucleoprotein particle U1 subunit C", "refseq_ac": [ { "id": "NP_650767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650767", "type": "external" } ], "gene_names_uniprotkb": "snRNP-U1-C; CG5454", "gene_names_refseq": "BcDNA:RH29440; CG5454; C; Dmel\\CG5454; SmC; SnRNP-U1-C; U1C; dU1-C; snRNP-U1-C; snRNP-U1C; snRNP-U1; snRNPC", "protein_names_uniprotkb": "U1 small nuclear ribonucleoprotein C; U1 snRNP C; U1-C; U1C", "protein_names_refseq": "CG5454-PA; small ribonucleoprotein particle U1 subunit C; snRNP-U1-C-PA; snRNPC", "tax_id": 7227, "disease": "mixed connective tissue disease (Disease Ontology:DOID:3492); connective tissue disease (Disease Ontology:DOID:65); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (dme:Dmel_CG5454); (R-DME-9770562)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10731132;11333025;12537572;15492211;1834995;19218244", "class_list": "", "function": "Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region (By similarity). Regulates alternative splicing of a distinct group of target genes., [UniProtKB, PubMed, PubMed, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030627 pre-mRNA 5'-splice site binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0030619 U1 snRNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0030532 small nuclear ribonucleoprotein complex;GO:0000243 commitment complex;GO:0071004 U2-type prespliceosome", "go_biological_process": "GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome;GO:0000381 regulation of alternative mRNA splicing, via spliceosome;GO:0000395 mRNA 5'-splice site recognition", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VE17-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VE46-1", "uniprot_id": [ { "id": "SC5A7_DROME", "url": "https://www.uniprot.org/uniprot/Q9VE46", "type": "external" } ], "mass": 66893.0, "length": 614, "protein_name": "High-affinity choline transporter 1", "gene_name": "ChT", "organism": "Fruit fly", "refseq_name": "choline transporter, isoform A", "refseq_ac": [ { "id": "NP_650743", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650743", "type": "external" } ], "gene_names_uniprotkb": "ChT; CG7708", "gene_names_refseq": "CG7708; ChT; Dmel\\CG7708; dSLC5A15", "protein_names_uniprotkb": "High-affinity choline transporter 1", "protein_names_refseq": "CG7708-PA; ChT-PA; choline transporter, isoform A", "tax_id": 7227, "disease": "congenital myasthenic syndrome 20 (Disease Ontology:DOID:0110661); autosomal dominant distal hereditary motor neuronopathy 7 (Disease Ontology:DOID:0111199); major depressive disorder (Disease Ontology:DOID:1470); depressive disorder (Disease Ontology:DOID:1596); asthma (Disease Ontology:DOID:2841)", "pathway": " (dme:Dmel_CG7708); (R-DME-264642); (R-DME-9958517)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Imports choline from the extracellular space to the neuron with high affinity. Rate-limiting step in acetylcholine synthesis. Sodium ion and chloride ion dependent (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4V340;Q961W3", "ec_number_list": [], "go_molecular_function": "GO:0015171 amino acid transmembrane transporter activity;GO:0015220 choline transmembrane transporter activity;GO:0005307 choline:sodium symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0008292 acetylcholine biosynthetic process;GO:0015871 choline transport;GO:0003333 amino acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VE46-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VE96-1", "uniprot_id": [ { "id": "Q9VE96_DROME", "url": "https://www.uniprot.org/uniprot/Q9VE96", "type": "external" } ], "mass": 62962.0, "length": 600, "protein_name": "Lethal (3) 05822, isoform A; Lethal (3) 05822, isoform B; Lethal (3) 05822, isoform C; Lethal (3) 05822, isoform D", "gene_name": "l(3)05822", "organism": "Fruit fly", "refseq_name": "lethal (3) 05822, isoform C", "refseq_ac": [ { "id": "NP_001262702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262702", "type": "external" } ], "gene_names_uniprotkb": "l(3)05822; 5822; CG7129; Dmel\\CG7129; Dmel_CG7129; L(3)05822; LD12970; clot 3142; l(3)5822", "gene_names_refseq": "5822; CG7129; Dmel\\CG7129; L(3)05822; LD12970; clot 3142; l(3)05822; l(3)5822", "protein_names_uniprotkb": "Lethal (3) 05822, isoform A; Lethal (3) 05822, isoform B; Lethal (3) 05822, isoform C; Lethal (3) 05822, isoform D", "protein_names_refseq": "CG7129-PC; l(3)05822-PC; lethal (3) 05822, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7129); (R-DME-432722); (R-DME-445355)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VE96-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VEA5-1", "uniprot_id": [ { "id": "RPB4_DROME", "url": "https://www.uniprot.org/uniprot/Q9VEA5", "type": "external" } ], "mass": 16212.0, "length": 139, "protein_name": "DNA-directed RNA polymerase II subunit Rpb4", "gene_name": "Polr2D", "organism": "Fruit fly", "refseq_name": "RNA polymerase II subunit D", "refseq_ac": [ { "id": "NP_001014633", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014633", "type": "external" } ], "gene_names_uniprotkb": "Polr2D; CG43662; Rpb4", "gene_names_refseq": "CG31237; CG33520; CG43662; CG7150; DmRPB4; DmRpb4; Dmel\\CG43662; Polr2D; RPB4; Rpb4; dRPB4; dRpb4", "protein_names_uniprotkb": "DNA-directed RNA polymerase II subunit Rpb4; RNA polymerase II subunit D", "protein_names_refseq": "CG43662-PF; Polr2D-PF; RNA polymerase II subunit D; RNA polymerase II subunit Rpb4; RNA polymerase II", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG43662); (R-DME-112382); (R-DME-113418); (R-DME-5578749); (R-DME-674695); (R-DME-6781823); (R-DME-6782135); (R-DME-6782210); (R-DME-6796648); (R-DME-6807505); (R-DME-72086); (R-DME-72163); (R-DME-72165); (R-DME-72203); (R-DME-73776); (R-DME-73779); (R-DME-75953); (R-DME-75955); (R-DME-76042); (R-DME-77075); (R-DME-9018519); (R-DME-9770562)", "pathway_count": 22, "publication_count": 5, "publication_id_list": "10731132;12482983;12537572;12697829;19921261", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Associates with POLR2G., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V3P8;Q8I0A4", "ec_number_list": [], "go_molecular_function": "GO:0000166 nucleotide binding;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005665 RNA polymerase II, core complex;GO:0005700 polytene chromosome;GO:0005703 polytene chromosome puff;GO:0005705 polytene chromosome interband", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VEA5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VEB5-1", "uniprot_id": [ { "id": "SRR1L_DROME", "url": "https://www.uniprot.org/uniprot/Q9VEB5", "type": "external" } ], "mass": 32273.0, "length": 276, "protein_name": "SRR1-like protein", "gene_name": "CG7988", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_650691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650691", "type": "external" } ], "gene_names_uniprotkb": "CG7988", "gene_names_refseq": "CG7988; Dmel\\CG7988", "protein_names_uniprotkb": "SRR1-like protein", "protein_names_refseq": "CG7988-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7988)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18327897", "class_list": "", "function": "Possible regulator involved in a circadian clock input pathway., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VEB5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VEC1-1", "uniprot_id": [ { "id": "MED17_DROME", "url": "https://www.uniprot.org/uniprot/Q9VEC1", "type": "external" } ], "mass": 71557.0, "length": 642, "protein_name": "Mediator of RNA polymerase II transcription subunit 17", "gene_name": "MED17", "organism": "Fruit fly", "refseq_name": "mediator complex subunit 17", "refseq_ac": [ { "id": "NP_650686", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650686", "type": "external" } ], "gene_names_uniprotkb": "MED17; CG7957; Trap80", "gene_names_refseq": "CG7957; Dmel\\CG7957; MED17; Med17; TRAP80; Trap80; dMED17; dTRAP80/SRB4; dTRAP80; dTrap80; l(3)s2956; p70", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 17; Mediator complex subunit 17; dMED17; dTRAP80", "protein_names_refseq": "CG7957-PA; MED17-PA; mediator complex subunit 17; mediator", "tax_id": 7227, "disease": "infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly (Disease Ontology:DOID:0111262)", "pathway": " (dme:Dmel_CG7957); (R-DME-9841922)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10731132;11090137;11259581;11511356;12021283;12537569;12537572;16751183", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA, MtnB and MtnD genes. Negatively regulates sex comb development., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005721 pericentric heterochromatin;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0060260 regulation of transcription initiation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9VEC1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VEG6-1", "uniprot_id": [ { "id": "PERC_DROME", "url": "https://www.uniprot.org/uniprot/Q9VEG6", "type": "external" } ], "mass": 90539.0, "length": 809, "protein_name": "Chorion peroxidase", "gene_name": "Pxt", "organism": "Fruit fly", "refseq_name": "Peroxinectin-like", "refseq_ac": [ { "id": "NP_650648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650648", "type": "external" } ], "gene_names_uniprotkb": "Pxt; CG7660", "gene_names_refseq": "CG7660; Dmel\\CG7660; Dpxt; Pxt; anon-WO0172774.128; pxd; pxt", "protein_names_uniprotkb": "Chorion peroxidase; 1.11.1.7; Dpxt; Peroxinectin-related protein", "protein_names_refseq": "CG7660-PB; Peroxinectin-like; Pxt-PB; pxd; pxt", "tax_id": 7227, "disease": "lupus nephritis (Disease Ontology:DOID:0080162); Alzheimer's disease 1 (Disease Ontology:DOID:0080348); cardiovascular system disease (Disease Ontology:DOID:1287); lung cancer (Disease Ontology:DOID:1324); cystic fibrosis (Disease Ontology:DOID:1485); keratosis (Disease Ontology:DOID:161); pancreatic cancer (Disease Ontology:DOID:1793); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); acute kidney failure (Disease Ontology:DOID:3021); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); lung disease (Disease Ontology:DOID:850); vasculitis (Disease Ontology:DOID:865); bacterial pneumonia (Disease Ontology:DOID:874); status asthmaticus (Disease Ontology:DOID:9362)", "pathway": " (dme:Dmel_CG7660)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12459925;12537569;12537572;18216169", "class_list": "", "function": "Required for ovarian follicle maturation. Involved in the formation of a rigid and insoluble egg chorion by catalyzing chorion protein cross-linking through dityrosine formation and phenol oxidase-catalyzed chorion melanization., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8IN93;Q8MRH7;Q9NBX0", "ec_number_list": [ { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.11.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004601 peroxidase activity;GO:0140825 lactoperoxidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0042744 hydrogen peroxide catabolic process;GO:0042743 hydrogen peroxide metabolic process;GO:0001516 prostaglandin biosynthetic process;GO:0007304 chorion-containing eggshell formation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VEG6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VER6-1", "uniprot_id": [ { "id": "MODSP_DROME", "url": "https://www.uniprot.org/uniprot/Q9VER6", "type": "external" } ], "mass": 69433.0, "length": 628, "protein_name": "Modular serine protease", "gene_name": "modSP", "organism": "Fruit fly", "refseq_name": "modular serine protease", "refseq_ac": [ { "id": "NP_536776", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536776", "type": "external" } ], "gene_names_uniprotkb": "modSP; CG31217; Ldlr", "gene_names_refseq": "CG10100; CG17557; CG31217; CT28389; Dm-SP; Dmel\\CG31217; LDL; Ldlr; ModSP; SP172; SP53; Ser89E; Tep6; W; X; modSP", "protein_names_uniprotkb": "Modular serine protease; 3.4.21.-", "protein_names_refseq": "CG31217-PA; low density lipoprotein receptor-like 'a' repeats; modSP-PA; modular serine protease; predicted gene W; predicted gene X; serine protease like 89E; serine protease-like", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31217)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;19590012;24794300", "class_list": "", "function": "Serine protease that plays a key role in innate immunity by activating the Toll pathway in response to infection with Gram-positive bacteria and fungi (PubMed:19590012, PubMed:24794300). During Gram-positive infection, acts downstream of PGRP-SA and upstream of Grass and Spz, and therefore appears to function in a pathway that links detection of Gram-positive lysine-type peptidoglycans to Toll activation (PubMed:19590012). Functions in a separate pathway to the psh-mediated activation of the Toll pathway (PubMed:19590012)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6NP02", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0045087 innate immune response;GO:0050830 defense response to Gram-positive bacterium;GO:0007168 receptor guanylyl cyclase signaling pathway;GO:0050832 defense response to fungus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VER6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VEX5-1", "uniprot_id": [ { "id": "INT13_DROME", "url": "https://www.uniprot.org/uniprot/Q9VEX5", "type": "external" } ], "mass": 75728.0, "length": 689, "protein_name": "Protein asunder", "gene_name": "Asun", "organism": "Fruit fly", "refseq_name": "asunder", "refseq_ac": [ { "id": "NP_524379", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524379", "type": "external" } ], "gene_names_uniprotkb": "Asun; CG6814; IntS13; Mat89Bb; ovary2", "gene_names_refseq": "ASUN; Asun; Asu; CG6814; Dmel\\CG6814; IntS13; Mat89Bb; asun", "protein_names_uniprotkb": "Protein asunder; Cell cycle regulator Mat89Bb; Integrator complex subunit 13; Maternal transcript 89Bb; Set apart in position or space protein", "protein_names_refseq": "CG6814-PA; asun-PA; asunder; integrator 13; maternal transcript 89Bb", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6814); (R-DME-6807505)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10731132;12537569;12537572;15737938;19357193;23097424;23904267;31530651;32966759;37995689;39032490;9799434", "class_list": "", "function": "Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:23097424, PubMed:32966759). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit Polr2A/Rbp1 and Spt5, and (2) degrading the exiting nascent RNA transcript via endonuclease activity (PubMed:32966759). The integrator complex is also involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:23097424). Plays a role as a regulator of spermatogenesis (PubMed:19357193). Crucial regulator of the mitotic cell cycle and development (PubMed:15737938, PubMed:19357193). Required for the correct dynein-dynactin perinuclear localization important for nucleus-centrosome coupling that occur upon meiotic progression of primary spermatocytes (PubMed:19357193, PubMed:23904267). Plays a role in sperm motility and fertility (PubMed:19357193). May have a role in the PNG/PLU/GNU pathway (PubMed:15737938)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q27924;Q7JP08", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0032039 integrator complex;GO:0160232 INTAC complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0051301 cell division;GO:0030317 flagellated sperm motility;GO:0007346 regulation of mitotic cell cycle;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VEX5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VEZ5-1", "uniprot_id": [ { "id": "IKKB_DROME", "url": "https://www.uniprot.org/uniprot/Q9VEZ5", "type": "external" } ], "mass": 86373.0, "length": 751, "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit beta", "gene_name": "IKKbeta", "organism": "Fruit fly", "refseq_name": "I-kappaB kinase beta", "refseq_ac": [ { "id": "NP_524751", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524751", "type": "external" } ], "gene_names_uniprotkb": "IKKbeta; CG4201; DIK; ird5", "gene_names_refseq": "CG4201; DIK; DLAK; DmIKKBeta; DmIKKbeta; DmIKKb; DmIKK; DmIkkbeta; Dmel\\CG4201; Dmikkbeta; Dmikkb; IKK-beta; IKKBeta; IKKB; IKKbeta; IKKb; IKK; IK; IRD-5; IRD5; Ikkbeta; Ikkb; Ik; Ird-5; Ird5; LRK; Lak; anon-89Bd; dIKK-beta; dIKKbeta; dIKK; dLak; dmIKKbeta; ikk; ird-5; ird5/DmIkk[beta]; ird5; ird[5]; ird", "protein_names_uniprotkb": "Inhibitor of nuclear factor kappa-B kinase subunit beta; 2.7.11.10; Cactus kinase IKK; DLAK; I-kappaB kinase subunit beta; IKK-like protein; Immune response deficient protein 5; Lipopolysaccharide-activated kinase", "protein_names_refseq": "CG4201-PB; I-kappaB kinase beta; IKK-like protein; IKKbeta-PB; LPS-responsive kinase; LPS-responsive-kinase; cactus kinase; immune response deficient 5; immune response-deficient 5; lipopolysaccharide activated kinase; mmune response deficient 5", "tax_id": 7227, "disease": "colitis (Disease Ontology:DOID:0060180); fetal encasement syndrome (Disease Ontology:DOID:0060647); immunodeficiency 15B (Disease Ontology:DOID:0111959); immunodeficiency 15A (Disease Ontology:DOID:0111960); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); breast cancer (Disease Ontology:DOID:1612); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); prostate adenocarcinoma (Disease Ontology:DOID:2526); dermatitis (Disease Ontology:DOID:2723); liver cancer (Disease Ontology:DOID:3571); pneumonia (Disease Ontology:DOID:552); muscular atrophy (Disease Ontology:DOID:767); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dme:Dmel_CG4201); (R-DME-1169091); (R-DME-1810476); (R-DME-198323); (R-DME-202424); (R-DME-209447); (R-DME-214399); (R-DME-2871837); (R-DME-445989); (R-DME-5357905); (R-DME-5607761); (R-DME-5607764); (R-DME-5676590); (R-DME-9020702); (R-DME-933542); (R-DME-937039); (R-DME-975144); (R-DME-9758274); (R-DME-9833482); (R-DME-9860927); (R-DME-9909505)", "pathway_count": 21, "publication_count": 14, "publication_id_list": "10636911;10731132;11018014;11156609;12537569;12537572;12732719;14519762;16081424;16311020;16894030;17158449;18327897;30119996", "class_list": "", "function": "Required for the activation of the NF-kappa-B factor Relish (Rel) by acting as an essential signaling component in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation, which is required for direct activation of Rel (PubMed:10636911, PubMed:11018014, PubMed:11156609, PubMed:30119996). Phosphorylates inhibitors of NF-kappa-B (cact) thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the NF-kappa-B inhibitor (PubMed:10636911, PubMed:11018014, PubMed:11156609). Essential for antibacterial immune response (PubMed:11018014). Also required for antiviral immune response (PubMed:30119996)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9GYV6;Q9NJI1;Q9U698;Q9U7F5", "ec_number_list": [ { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.22.61", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.61", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0008384 IkappaB kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0008385 IkappaB kinase complex", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051607 defense response to virus;GO:0071456 cellular response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VEZ5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VF26-1", "uniprot_id": [ { "id": "SPNE_DROME", "url": "https://www.uniprot.org/uniprot/Q9VF26", "type": "external" } ], "mass": 164510.0, "length": 1434, "protein_name": "Probable ATP-dependent RNA helicase spindle-E", "gene_name": "spn-E", "organism": "Fruit fly", "refseq_name": "spindle E", "refseq_ac": [ { "id": "NP_476741", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476741", "type": "external" } ], "gene_names_uniprotkb": "spn-E; CG3158; hls", "gene_names_refseq": "CG3158; Dmel\\CG3158; SPN-E; Spindle-E; Spn-E; SpnE; fs(1)hls; fs(3)hls; hes; hls; homeless; spin-E; spn E; spn-E/hls; spn-E; spnE", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase spindle-E; 3.6.4.13; Protein homeless", "protein_names_refseq": "CG3158-PA; Spindle-E (homeless); SpindleE; female sterile(3)homeless; homeless/spindle-E; spindle E; spindle-E; spn-E-PA", "tax_id": 7227, "disease": "spermatogenic failure 30 (Disease Ontology:DOID:0111913)", "pathway": " (dme:Dmel_CG3158)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;11470406;11513298;12154120;12537572;14752161;15254241;16452506;16809489;17194939;17428915;17603126;17941712;19651888;26295961;7590230", "class_list": "", "function": "Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repressing specialized telomeric retroelements HeT-A, TAHRE, and TART; Drosophila telomeres being maintained by transposition of specialized telomeric retroelements. Involved in telomeric trans-silencing, a repression mechanism by which a transposon or a transgene inserted in subtelomeric heterochromatin has the capacity to repress in trans in the female germline, a homologous transposon, or transgene located in euchromatin. Involved in the repression of testis-expressed Stellate genes by the homologous Su(Ste) repeats. Required for anteroposterior and dorsoventral axis formation during oogenesis. Key component of the perinuclear meiotic nuage, an electron dense structure involved in the post-transcriptional regulation of transposons and mRNAs; required for recruitment of other nuage comonents including vas, krimp, aub and mael (PubMed:17428915). May have a role in production of piwi-interacting RNA (piRNA) (PubMed:17428915)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RVD0;Q26453", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.-.-.-", "type": "external" }, { "id": "5.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0004386 helicase activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0043186 P granule", "go_biological_process": "GO:0009949 polarity specification of anterior/posterior axis;GO:0007283 spermatogenesis;GO:0007076 mitotic chromosome condensation;GO:0001556 oocyte maturation;GO:0048477 oogenesis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9VF26-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VFB2-1", "uniprot_id": [ { "id": "RT10_DROME", "url": "https://www.uniprot.org/uniprot/Q9VFB2", "type": "external" } ], "mass": 20031.0, "length": 173, "protein_name": "Small ribosomal subunit protein uS10m", "gene_name": "mRpS10", "organism": "Fruit fly", "refseq_name": "mitochondrial ribosomal protein S10, isoform B", "refseq_ac": [ { "id": "NP_524355", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524355", "type": "external" } ], "gene_names_uniprotkb": "mRpS10; CG4247", "gene_names_refseq": "BcDNA:GM25447; CG4247; Dmel\\CG4247; MRP-S10; MrpS10; mRpS10", "protein_names_uniprotkb": "Small ribosomal subunit protein uS10m; 28S ribosomal protein S10, mitochondrial; MRP-S10; S10mt", "protein_names_refseq": "CG4247-PB; mRpS10-PB; mitochondrial ribosomal protein S10, isoform B; mitochondrial ribosomal protein S10", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4247); (R-DME-5389840); (R-DME-5419276); (R-DME-9837999); (R-DME-9937383)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8JR11;Q8IH25;Q8INE7;Q8SYL8", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VFB2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VFB7-1", "uniprot_id": [ { "id": "TPC10_DROME", "url": "https://www.uniprot.org/uniprot/Q9VFB7", "type": "external" } ], "mass": 130804.0, "length": 1145, "protein_name": "Trafficking protein particle complex subunit 10", "gene_name": "SIDL", "organism": "Fruit fly", "refseq_name": "shal interactor of Di-Leucine motif", "refseq_ac": [ { "id": "NP_650431", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650431", "type": "external" } ], "gene_names_uniprotkb": "SIDL; CG6623", "gene_names_refseq": "CG6623; Dmel\\CG6623; SIDL; TRAPPC10", "protein_names_uniprotkb": "Trafficking protein particle complex subunit 10; Shal Interactor of Di-Leucine Motif; TRAPP subunit TMEM1; Trafficking protein particle complex subunit TMEM1; Transport protein particle subunit TMEM1", "protein_names_refseq": "CG6623-PA; SIDL-PA; shal interactor of Di-Leucine motif", "tax_id": 7227, "disease": "agnathia-otocephaly complex (Disease Ontology:DOID:0060341); velocardiofacial syndrome (Disease Ontology:DOID:12583)", "pathway": " (dme:Dmel_CG6623); (R-DME-204005); (R-DME-8876198)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;20550966", "class_list": "", "function": "May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity). Has a role in one of the several mechanisms underlying dendritic localization of Shal channels., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q540Y2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0030425 dendrite;GO:0043204 perikaryon;GO:0030008 TRAPP complex", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0048193 Golgi vesicle transport;GO:0006891 intra-Golgi vesicle-mediated transport;GO:0034498 early endosome to Golgi transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VFB7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VFC2-1", "uniprot_id": [ { "id": "SP88E_DROME", "url": "https://www.uniprot.org/uniprot/Q9VFC2", "type": "external" } ], "mass": 48476.0, "length": 427, "protein_name": "Serine protease inhibitor 88Ea", "gene_name": "Spn88Ea", "organism": "Fruit fly", "refseq_name": "serpin 88Ea, isoform A", "refseq_ac": [ { "id": "NP_524954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524954", "type": "external" } ], "gene_names_uniprotkb": "Spn88Ea; CG18525; Spn5", "gene_names_refseq": "CG18525; Dmel\\CG18525; Sp5; Spn5; Spn88Ea; sp5; spn5", "protein_names_uniprotkb": "Serine protease inhibitor 88Ea; Serpin 88Ea", "protein_names_refseq": "CG18525-PA; Dm-serpin-88Ea; Spn88Ea-PA; serine protease inhibitor 5; serpin 5; serpin 88Ea, isoform A; serpin5; serpin", "tax_id": 7227, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); coarctation of the aorta (Disease Ontology:DOID:0051054); stroke (Disease Ontology:DOID:0051061); chemical colitis (Disease Ontology:DOID:0060186); ileitis (Disease Ontology:DOID:0060189); atrial fibrillation (Disease Ontology:DOID:0060224); thrombosis (Disease Ontology:DOID:0060903); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); Nagashima-type palmoplantar keratosis (Disease Ontology:DOID:0070555); polycystic kidney disease (Disease Ontology:DOID:0080322); corticosteroid-binding globulin deficiency (Disease Ontology:DOID:0090030); osteonecrosis (Disease Ontology:DOID:10159); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); nephritis (Disease Ontology:DOID:10952); meconium aspiration syndrome (Disease Ontology:DOID:11049); hydronephrosis (Disease Ontology:DOID:11111); IgA vasculitis (Disease Ontology:DOID:11123); disseminated intravascular coagulation (Disease Ontology:DOID:11247); adult respiratory distress syndrome (Disease Ontology:DOID:11394); pulmonary edema (Disease Ontology:DOID:11396); sciatic neuropathy (Disease Ontology:DOID:11446); familial hyperlipidemia (Disease Ontology:DOID:1168); prediabetes syndrome (Disease Ontology:DOID:11716); nephrotic syndrome (Disease Ontology:DOID:1184); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); allergic disease (Disease Ontology:DOID:1205); otosclerosis (Disease Ontology:DOID:12185); primary biliary cholangitis (Disease Ontology:DOID:12236); alcoholic hepatitis (Disease Ontology:DOID:12351); dilated cardiomyopathy (Disease Ontology:DOID:12930); retinopathy of prematurity (Disease Ontology:DOID:13025); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); uveitis (Disease Ontology:DOID:13141); alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372); sick sinus syndrome (Disease Ontology:DOID:13884); toxic shock syndrome (Disease Ontology:DOID:14115); Fabry disease (Disease Ontology:DOID:14499); cystic fibrosis (Disease Ontology:DOID:1485); diffuse scleroderma (Disease Ontology:DOID:1580); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); impotence (Disease Ontology:DOID:1875); atherosclerosis (Disease Ontology:DOID:1936); hyperinsulinism (Disease Ontology:DOID:2018); transient cerebral ischemia (Disease Ontology:DOID:224); arteriosclerosis (Disease Ontology:DOID:2349); multiple sclerosis (Disease Ontology:DOID:2377); ovarian cancer (Disease Ontology:DOID:2394); central retinal vein occlusion (Disease Ontology:DOID:2450); endometriosis (Disease Ontology:DOID:289); acute pancreatitis (Disease Ontology:DOID:2913); glomerulonephritis (Disease Ontology:DOID:2921); severe acute respiratory syndrome (Disease Ontology:DOID:2945); IgA glomerulonephritis (Disease Ontology:DOID:2986); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); temporal lobe epilepsy (Disease Ontology:DOID:3328); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); antithrombin III deficiency (Disease Ontology:DOID:3755); pulmonary fibrosis (Disease Ontology:DOID:3770); lung adenocarcinoma (Disease Ontology:DOID:3910); liver disease (Disease Ontology:DOID:409); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); cerebrovascular disease (Disease Ontology:DOID:6713); hepatocellular carcinoma (Disease Ontology:DOID:684); osteoarthritis (Disease Ontology:DOID:8398); chronic myeloid leukemia (Disease Ontology:DOID:8552); vasculitis (Disease Ontology:DOID:865); intermediate coronary syndrome (Disease Ontology:DOID:8805); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675); mitral valve prolapse (Disease Ontology:DOID:988); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG18525); (R-DME-114608); (R-DME-1650814); (R-DME-381426); (R-DME-6798695); (R-DME-8939242); (R-DME-8957275); (R-DME-9855719); (R-DME-9948001)", "pathway_count": 9, "publication_count": 6, "publication_id_list": "10692585;10731132;12537569;12537572;18956323;19581577", "class_list": "", "function": "Serine protease inhibitor with activity toward trypsin (PubMed:18956323). Negatively regulates the Toll signaling pathway and suppresses the expression of the antifungal peptide drosomycin (PubMed:19581577). Its negative regulation of the Toll signaling pathway also results in the inhibition of the melanization immune response via the phenoloxidase (PPO1) cascade (PubMed:19581577). Essential for unfolding and expansion of the wings after emergence from the pupal case (PubMed:18956323). May regulate the Toll pathway by blocking the proteolysis of the Toll ligand spz (PubMed:19581577)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 92, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9U1I4", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0050776 regulation of immune response;GO:0045861 negative regulation of proteolysis;GO:0042438 melanin biosynthetic process;GO:0002376 immune system process;GO:0045824 negative regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VFC2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VFE6-1", "uniprot_id": [ { "id": "RRP15_DROME", "url": "https://www.uniprot.org/uniprot/Q9VFE6", "type": "external" } ], "mass": 31206.0, "length": 276, "protein_name": "RRP15-like protein", "gene_name": "CG3817", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_650405", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650405", "type": "external" } ], "gene_names_uniprotkb": "CG3817", "gene_names_refseq": "CG3817; Dmel\\CG3817; RRP15", "protein_names_uniprotkb": "RRP15-like protein", "protein_names_refseq": "CG3817-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3817)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18327897", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95T28", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0000460 maturation of 5.8S rRNA;GO:0000470 maturation of LSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VFE6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VFK3-1", "uniprot_id": [ { "id": "SOTI_DROME", "url": "https://www.uniprot.org/uniprot/Q9VFK3", "type": "external" } ], "mass": 16714.0, "length": 147, "protein_name": "Male-specific protein scotti", "gene_name": "soti", "organism": "Fruit fly", "refseq_name": "scotti", "refseq_ac": [ { "id": "NP_650358", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650358", "type": "external" } ], "gene_names_uniprotkb": "soti; CG8489", "gene_names_refseq": "CG8489; Dmel\\CG8489; Soti; soti", "protein_names_uniprotkb": "Male-specific protein scotti", "protein_names_refseq": "CG8489-PA; scotti; soti-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8489)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;18434411", "class_list": "", "function": "Post-meiotically transcribed gene that has a role in late spermiogenesis; required for actin cone progression during spermatid individualization., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007291 sperm individualization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VFK3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VFL5-1", "uniprot_id": [ { "id": "SYMM_DROME", "url": "https://www.uniprot.org/uniprot/Q9VFL5", "type": "external" } ], "mass": 65998.0, "length": 582, "protein_name": "Methionine--tRNA ligase, mitochondrial", "gene_name": "MetRS-m", "organism": "Fruit fly", "refseq_name": "Methionyl-tRNA synthetase, mitochondrial, isoform B", "refseq_ac": [ { "id": "NP_001262564", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262564", "type": "external" } ], "gene_names_uniprotkb": "MetRS-m; Aats-met-m; Aats-met; CG31322; CG8684", "gene_names_refseq": "Aats-Met; Aats-met-m; Aats-met; CG31322; CG8684; CG9612; Dmel\\CG31322; MRS; MetRS-m; MetRS; dMARS", "protein_names_uniprotkb": "Methionine--tRNA ligase, mitochondrial; 6.1.1.10; Mitochondrial methionyl-tRNA synthetase; MtMetRS", "protein_names_refseq": "CG31322-PB; MetRS-m-PB; Methionyl-tRNA synthetase, mitochondrial, isoform B; Methionyl-tRNA synthetase; mitochondrial methionyl-tRNA synthetase", "tax_id": 7227, "disease": "spastic ataxia 3 (Disease Ontology:DOID:0050942); combined oxidative phosphorylation deficiency 25 (Disease Ontology:DOID:0111468); neurodegenerative disease (Disease Ontology:DOID:1289); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (dme:Dmel_CG31322)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;22448145;25594180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4KH54;Q8T0Q6", "ec_number_list": [ { "id": "6.1.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004825 methionine-tRNA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006431 methionyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VFL5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VFP2-1", "uniprot_id": [ { "id": "RDX_DROME", "url": "https://www.uniprot.org/uniprot/Q9VFP2", "type": "external" } ], "mass": 89667.0, "length": 829, "protein_name": "Protein roadkill", "gene_name": "rdx", "organism": "Fruit fly", "refseq_name": "roadkill, isoform C", "refseq_ac": [ { "id": "NP_650325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650325", "type": "external" } ], "gene_names_uniprotkb": "rdx; CG12537; HIB", "gene_names_refseq": "0869/09; BEST:GM07940; CG10235; CG12537; CG9924; D-SPOP; Dmel\\CG12537; Dromel_CG9924_FBtr0082871_rdx_mORF; HIB; Hib; Rdx; SPOP; Spop; anon-WO0118547.577; hib; l(3)03477; l(3)2004; l(3)88Aa; l(3)A6; l(3)S086909; l(3)SG40; l(3)dsl-6; l(3)dsl6; l(3)j1D1; l(3)j4C7; mei-P19; rdx", "protein_names_uniprotkb": "Protein roadkill; Hh-induced MATH and BTB domain-containing protein", "protein_names_refseq": "CG12537-PC; Cul3-Hedghog-induced MATH and BTB domain-containing protein; Hh-induced MATH and BTB domain containing protein; hedegehog-induced BTB protein; hedgehog- induced BTB protein; lethal (3) S086909; meiotic P19; rdx-PC; roadkill, isoform C; roadkill", "tax_id": 7227, "disease": "stomach cancer (Disease Ontology:DOID:10534); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dme:Dmel_CG12537); (R-DME-216167); (R-DME-5632684); (R-DME-9929491)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10731132;12537569;12537572;15331761;16651542;16740475;17102630", "class_list": "", "function": "Involved in segment polarity. In complex with gft/CUL3, promotes ubiquitination of ci and its subsequent degradation by the proteasome, which results in hh signaling attenuation. This regulation may be important during eye formation for proper packing of ommatidia into a hexagonal array., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V2V6;Q15BT8;Q5BIA3;Q7KSK6;Q8ING4;Q8MRB4;Q9VFP3", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0031625 ubiquitin protein ligase binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0046330 positive regulation of JNK cascade;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0030162 regulation of proteolysis;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9VFP2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VGP6-1", "uniprot_id": [ { "id": "PFD3_DROME", "url": "https://www.uniprot.org/uniprot/Q9VGP6", "type": "external" } ], "mass": 22314.0, "length": 194, "protein_name": "Prefoldin subunit 3", "gene_name": "mgr", "organism": "Fruit fly", "refseq_name": "merry-go-round", "refseq_ac": [ { "id": "NP_650067", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650067", "type": "external" } ], "gene_names_uniprotkb": "mgr; CG6719", "gene_names_refseq": "BcDNA:LD34406; CG6719; Dmel\\CG6719; Mgr; PAC10; Pfdn3; mgr", "protein_names_uniprotkb": "Prefoldin subunit 3; Protein merry-go-round; von Hippel-Lindau-binding protein 1", "protein_names_refseq": "CG6719-PA; merry-go-round; mgr-PA; prefoldin 3", "tax_id": 7227, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (dme:Dmel_CG6719)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;22451918;3138251", "class_list": "", "function": "Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Required for tubulin stability and spindle and centrosome formation in cooperation with Vhl., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q86PA8", "ec_number_list": [], "go_molecular_function": "GO:0015631 tubulin binding;GO:0048487 beta-tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016272 prefoldin complex", "go_biological_process": "GO:0090307 mitotic spindle assembly;GO:0006457 protein folding;GO:0007098 centrosome cycle;GO:0007021 tubulin complex assembly;GO:0090306 meiotic spindle assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VGP6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VGR2-1", "uniprot_id": [ { "id": "NDUF7_DROME", "url": "https://www.uniprot.org/uniprot/Q9VGR2", "type": "external" } ], "mass": 49068.0, "length": 437, "protein_name": "Protein arginine methyltransferase NDUFAF7 homolog, mitochondrial", "gene_name": "CG17726", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_650054", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650054", "type": "external" } ], "gene_names_uniprotkb": "CG17726", "gene_names_refseq": "CG17726; Dmel\\CG17726", "protein_names_uniprotkb": "Protein arginine methyltransferase NDUFAF7 homolog, mitochondrial; 2.1.1.320; NADH dehydrogenase [ubiquinone] complex I, assembly factor 7 homolog; Protein midA homolog", "protein_names_refseq": "CG17726-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17726); (R-DME-6799198)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NLJ4;Q8MYZ3;Q95S80", "ec_number_list": [ { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" } ], "go_molecular_function": "GO:0035243 protein-arginine omega-N symmetric methyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VGR2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VGZ8-1", "uniprot_id": [ { "id": "SLEL_DROME", "url": "https://www.uniprot.org/uniprot/Q9VGZ8", "type": "external" } ], "mass": 75699.0, "length": 674, "protein_name": "Slender lobes-like protein", "gene_name": "CG12592", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_731474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_731474", "type": "external" } ], "gene_names_uniprotkb": "CG12592", "gene_names_refseq": "CG12592-PA; CG12592; Dmel\\CG12592", "protein_names_uniprotkb": "Slender lobes-like protein", "protein_names_refseq": "CG12592-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12592)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;17372656", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8T3Q6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VGZ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VH07-1", "uniprot_id": [ { "id": "RUVB1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VH07", "type": "external" } ], "mass": 50242.0, "length": 456, "protein_name": "RuvB-like helicase 1", "gene_name": "pont", "organism": "Fruit fly", "refseq_name": "pontin", "refseq_ac": [ { "id": "NP_652608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_652608", "type": "external" } ], "gene_names_uniprotkb": "pont; CG4003", "gene_names_refseq": "0229/05; CG4003; Dmel\\CG4003; PONT; PON; Pontin; Pont; RUVBL1; Tip49/Pontin; Tip49; anon-WO0118547.698; dPontin; dPon; dRUVBL1; dpon; l(3)S022905; pont; pon", "protein_names_uniprotkb": "RuvB-like helicase 1; 3.6.4.12; Dpontin; Dpon; Pontin", "protein_names_refseq": "CG4003-PA; dpontin; pont-PA; pontin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4003); (R-DME-201722); (R-DME-5689603); (R-DME-5689880); (R-DME-5696394)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "10731132;11080158;12537569;12537572;15528408;16087886;16618800;32432549", "class_list": "", "function": "Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (By similarity). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of histone H4 'Lys-12' (PubMed:32432549). Component of a SWR1-like complex that incorporates H2A.V genome-wide and specifically at active promoters, in an ATP-dependent manner (PubMed:32432549). Component of the Tip60 chromatin-remodeling complex that upon induction of DNA double-strand breaks, mediates the ATP-dependent exchange of unmodified histone H2AV for its phosphorylated and acetylated form H2AVK5acS138ph, leading to transcriptional regulation of selected genes by chromatin remodeling (PubMed:15528408). Component of the chromatin-remodeling INO80 complex (By similarity). Binds beta-catenin, to positively regulate Wnt-responsive targets (PubMed:11080158). Also an essential cofactor for the normal function of Myc; required for cellular proliferation and growth (PubMed:16087886)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9NH53;Q9VH06", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.-.-.-", "type": "external" }, { "id": "5.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0097255 R2TP complex;GO:0005634 nucleus;GO:0031011 Ino80 complex;GO:0035267 NuA4 histone acetyltransferase complex;GO:0000812 Swr1 complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9VH07-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VHB0-1", "uniprot_id": [ { "id": "SON_DROME", "url": "https://www.uniprot.org/uniprot/Q9VHB0", "type": "external" } ], "mass": 97760.0, "length": 874, "protein_name": "Protein Son", "gene_name": "Son", "organism": "Fruit fly", "refseq_name": "Son RNA binding protein, isoform B", "refseq_ac": [ { "id": "NP_001262426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262426", "type": "external" } ], "gene_names_uniprotkb": "Son; CG8273; dsn", "gene_names_refseq": "CG8273; Dmel\\CG8273; Son; cg8273; dSon; dsn", "protein_names_uniprotkb": "Protein Son; RNA-binding protein Son", "protein_names_refseq": "CG8273-PB; Son DNA binding protein; Son RNA binding protein, isoform B; Son-PB", "tax_id": 7227, "disease": "ZTTK syndrome (Disease Ontology:DOID:0060953); congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay (Disease Ontology:DOID:0112359); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (dme:Dmel_CG8273)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;29887366;31730657", "class_list": "", "function": "RNA-binding protein that protects nascent transcripts containing intronic transposable sequences, known as INE-1, from being degraded by DIP1 (PubMed:31730657). Modulates DIP1 activity by repressing its sumoylation levels (PubMed:31730657). This ensures that intronic sequences will be degradated only after splicing (PubMed:31730657). In the ovaries, regulates germline stem cells (GSCs) self-renewal by repressing the expression of the GSC differentiation-promoting factor Rga (PubMed:29887366)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8IHA8;Q8MSG7", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:2000036 regulation of stem cell population maintenance;GO:0048024 regulation of mRNA splicing, via spliceosome;GO:1990261 pre-mRNA catabolic process;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VHB0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VHE6-1", "uniprot_id": [ { "id": "OR85F_DROME", "url": "https://www.uniprot.org/uniprot/Q9VHE6", "type": "external" } ], "mass": 45343.0, "length": 392, "protein_name": "Odorant receptor 85f", "gene_name": "Or85f", "organism": "Fruit fly", "refseq_name": "odorant receptor 85f", "refseq_ac": [ { "id": "NP_524289", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524289", "type": "external" } ], "gene_names_uniprotkb": "Or85f; CG16755", "gene_names_refseq": "85D.1; 85f; CG16755; DOR32; DmOr85f; Dmel\\CG16755; OR85f; Or85f", "protein_names_uniprotkb": "Odorant receptor 85f", "protein_names_refseq": "CG16755-PA; Or85f-PA; odorant receptor 85f", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG16755)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;10943836;12537572;16615896", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VHE6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VHI4-1", "uniprot_id": [ { "id": "SF3B5_DROME", "url": "https://www.uniprot.org/uniprot/Q9VHI4", "type": "external" } ], "mass": 9971.0, "length": 85, "protein_name": "Splicing factor 3B subunit 5", "gene_name": "Sf3b5", "organism": "Fruit fly", "refseq_name": "splicing factor 3b subunit 5", "refseq_ac": [ { "id": "NP_652189", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_652189", "type": "external" } ], "gene_names_uniprotkb": "Sf3b5; CG11985", "gene_names_refseq": "CG11985; Dmel\\CG11985; SF3B5; Sf3b5; sf3b5", "protein_names_uniprotkb": "Splicing factor 3B subunit 5; Pre-mRNA-splicing factor SF3b 10 kDa subunit", "protein_names_refseq": "CG11985-PA; Sf3b5-PA; splicing factor 3b subunit 5", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11985); (R-DME-72163); (R-DME-72165); (R-DME-9770562); (R-DME-9943411)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "10731132;12537572;18981222;27035939;27185460", "class_list": "", "function": "Involved in pre-mRNA splicing as component of spliceosome (PubMed:18981222, PubMed:27185460). As part of the spliceosome complex, plays a role in the regulation of spermatogonial differentiation (PubMed:27035939). When associated with the SAGA transcription regulatory histone acetylation (HAT) complex, might be involved in the transcriptional activation of a subset of SAGA-regulated genes (PubMed:27185460)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005686 U2 snRNP;GO:0071011 precatalytic spliceosome;GO:0000124 SAGA complex", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0010468 regulation of gene expression;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VHI4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VHM2-1", "uniprot_id": [ { "id": "VP35L_DROME", "url": "https://www.uniprot.org/uniprot/Q9VHM2", "type": "external" } ], "mass": 107596.0, "length": 942, "protein_name": "VPS35 endosomal protein sorting factor-like", "gene_name": "CG8202", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_649826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649826", "type": "external" } ], "gene_names_uniprotkb": "CG8202", "gene_names_refseq": "CG8202; Dmel\\CG8202", "protein_names_uniprotkb": "VPS35 endosomal protein sorting factor-like", "protein_names_refseq": "CG8202-PA; uncharacterized protein", "tax_id": 7227, "disease": "Ritscher-Schinzel syndrome (Disease Ontology:DOID:0060565)", "pathway": " (dme:Dmel_CG8202); (R-DME-6798695)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Acts as a component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q960B2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005768 endosome", "go_biological_process": "GO:0015031 protein transport;GO:0032456 endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VHM2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VHM6-1", "uniprot_id": [ { "id": "OUIB_DROME", "url": "https://www.uniprot.org/uniprot/Q9VHM6", "type": "external" } ], "mass": 36244.0, "length": 312, "protein_name": "Transcription factor Ouib", "gene_name": "Ouib", "organism": "Fruit fly", "refseq_name": "ouija board", "refseq_ac": [ { "id": "NP_649822", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649822", "type": "external" } ], "gene_names_uniprotkb": "Ouib; CG11762", "gene_names_refseq": "CG11762; Dmel\\CG11762; Ouib; i36; ouib", "protein_names_uniprotkb": "Transcription factor Ouib; Protein ouija board", "protein_names_refseq": "CG11762-PA; ouib-PA; ouija board; ouijaboard", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11762)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;26658797", "class_list": "", "function": "Transcription factor required for ecdysteroid production in the prothoracic gland by activating transcription of the ecdysteroid biosynthesis gene spok. Binds to the 5'-AGCTTTATTATTTAG-3' DNA sequence in the spok enhancer region., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C1C5A4;Q0IGS6", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0002168 instar larval development;GO:0045998 positive regulation of ecdysteroid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VHM6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VHM7-1", "uniprot_id": [ { "id": "Q9VHM7_DROME", "url": "https://www.uniprot.org/uniprot/Q9VHM7", "type": "external" } ], "mass": 42116.0, "length": 370, "protein_name": "Numerous disordered muscles, isoform A; Numerous disordered muscles, isoform B; Numerous disordered muscles, isoform C", "gene_name": "nom", "organism": "Fruit fly", "refseq_name": "numerous disordered muscles, isoform B", "refseq_ac": [ { "id": "NP_001262384", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262384", "type": "external" } ], "gene_names_uniprotkb": "nom; CG8145; Dmel\\CG8145; Dmel_CG8145; Sean", "gene_names_refseq": "CG8145; Dmel\\CG8145; Sean; nom", "protein_names_uniprotkb": "Numerous disordered muscles, isoform A; Numerous disordered muscles, isoform B; Numerous disordered muscles, isoform C", "protein_names_refseq": "CG8145-PB; nom-PB; numerous disordered muscles, isoform B; numerous disordered muscles; seance", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8145)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0007526 larval somatic muscle development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VHM7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VHN5-1", "uniprot_id": [ { "id": "UNC50_DROME", "url": "https://www.uniprot.org/uniprot/Q9VHN5", "type": "external" } ], "mass": 32472.0, "length": 275, "protein_name": "Protein unc-50 homolog", "gene_name": "Unc50", "organism": "Fruit fly", "refseq_name": "Unc50 RNA binding protein", "refseq_ac": [ { "id": "NP_649813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649813", "type": "external" } ], "gene_names_uniprotkb": "Unc50; CG9773", "gene_names_refseq": "CG9773; DmUNC-50; Dmel\\CG9773; Unc50", "protein_names_uniprotkb": "Protein unc-50 homolog; Uncoordinated-like protein", "protein_names_refseq": "CG9773-PA; Unc50 RNA binding protein; Unc50-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9773)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;10980252;12537569;12537572", "class_list": "", "function": "Required for cell surface expression of acetylcholine receptors., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VHN5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VHN6-1", "uniprot_id": [ { "id": "RM19_DROME", "url": "https://www.uniprot.org/uniprot/Q9VHN6", "type": "external" } ], "mass": 36193.0, "length": 306, "protein_name": "Large ribosomal subunit protein bL19m", "gene_name": "mRpL19", "organism": "Fruit fly", "refseq_name": "mitochondrial ribosomal protein L19", "refseq_ac": [ { "id": "NP_524284", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524284", "type": "external" } ], "gene_names_uniprotkb": "mRpL19; CG8039", "gene_names_refseq": "CG8039; Dmel\\CG8039; L19; RpL19; mRPL19; mRpL19", "protein_names_uniprotkb": "Large ribosomal subunit protein bL19m; 39S ribosomal protein L19, mitochondrial; L19mt; MRP-L19", "protein_names_refseq": "CG8039-PA; mRpL19-PA; mitochondrial ribosomal protein L19", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8039); (R-DME-5389840); (R-DME-5419276); (R-DME-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VHN6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VHQ2-1", "uniprot_id": [ { "id": "OR85D_DROME", "url": "https://www.uniprot.org/uniprot/Q9VHQ2", "type": "external" } ], "mass": 47987.0, "length": 412, "protein_name": "Putative odorant receptor 85d", "gene_name": "Or85d", "organism": "Fruit fly", "refseq_name": "odorant receptor 85d", "refseq_ac": [ { "id": "NP_524281", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524281", "type": "external" } ], "gene_names_uniprotkb": "Or85d; CG11742", "gene_names_refseq": "85.2; 85A.2; 85d; CG11742; DOR114; Dmel\\CG11742; Or85d", "protein_names_uniprotkb": "Putative odorant receptor 85d", "protein_names_refseq": "CG11742-PA; Or85d-PA; odorant receptor 85d", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11742)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;10943836;12537572", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VHQ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VHV1-1", "uniprot_id": [ { "id": "POLI_DROME", "url": "https://www.uniprot.org/uniprot/Q9VHV1", "type": "external" } ], "mass": 80390.0, "length": 737, "protein_name": "DNA polymerase iota", "gene_name": "PolI", "organism": "Fruit fly", "refseq_name": "DNA polymerase iota, isoform C", "refseq_ac": [ { "id": "NP_001287227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287227", "type": "external" } ], "gene_names_uniprotkb": "PolI; CG7602; DNApol-iota; DNApolI; drad30B", "gene_names_refseq": "AAF54198; CG7602; DNA Pol II-iota; DNA-pol iota; DNApol-iota; DNApol-i; Dm-Poliota; Dmel\\CG7602; PolI; Poliota; drad30B", "protein_names_uniprotkb": "DNA polymerase iota; 2.7.7.7", "protein_names_refseq": "CG7602-PC; DNA polymerase iota, isoform C; DNApol-iota; PolI-PC", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7602); (R-DME-5656121); (R-DME-5656169)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10731132;11297519;12537569;12537572", "class_list": "", "function": "Error-prone DNA polymerase specifically involved in DNA repair (PubMed:11297519). Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:11297519). Favors Hoogsteen base-pairing in the active site (By similarity). Inserts the correct base with higher fidelity opposite an adenosine template (PubMed:11297519). Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine (PubMed:11297519). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0046872 metal ion binding;GO:0003684 damaged DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006281 DNA repair;GO:0019985 translesion synthesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VHV1-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VI10-1", "uniprot_id": [ { "id": "SMD2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VI10", "type": "external" } ], "mass": 13504.0, "length": 119, "protein_name": "Probable small nuclear ribonucleoprotein Sm D2", "gene_name": "SmD2", "organism": "Fruit fly", "refseq_name": "small ribonucleoprotein particle protein SmD2", "refseq_ac": [ { "id": "NP_649645", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649645", "type": "external" } ], "gene_names_uniprotkb": "SmD2; CG1249; snRNP2", "gene_names_refseq": "BcDNA:LD03002; CG1249; D2-Sm; Dmel\\CG1249; SMD2_DROME; SmD2; Smd2; dD2; snRNP D2; snRNP2", "protein_names_uniprotkb": "Probable small nuclear ribonucleoprotein Sm D2; Sm-D2; snRNP core protein D2", "protein_names_refseq": "CG1249-PA; SmD2-PA; small ribonucleoprotein particle protein D2; small ribonucleoprotein particle protein SmD2; snRNP2", "tax_id": 7227, "disease": "systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (dme:Dmel_CG1249); (R-DME-72163); (R-DME-72165); (R-DME-9770562); (R-DME-9943411)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "10731132;10908584;12537569;12537572;17412918;18621711", "class_list": "", "function": "Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005829 cytosol;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome;GO:0005686 U2 snRNP", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome;GO:0000380 alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VI10-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VI82-1", "uniprot_id": [ { "id": "NOC3L_DROME", "url": "https://www.uniprot.org/uniprot/Q9VI82", "type": "external" } ], "mass": 94492.0, "length": 822, "protein_name": "Nucleolar complex protein 3", "gene_name": "Noc3", "organism": "Fruit fly", "refseq_name": "nucleolar complex protein 3", "refseq_ac": [ { "id": "NP_649710", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649710", "type": "external" } ], "gene_names_uniprotkb": "Noc3; CG1234", "gene_names_refseq": "CG1234; Dmel\\CG1234; NOC3; Noc3", "protein_names_uniprotkb": "Nucleolar complex protein 3; NOC3-like protein; Nucleolar complex-associated protein 3-like protein", "protein_names_refseq": "CG1234-PA; Noc3-PA; nucleolar complex protein 3; nucleolar complex protein-3", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1234)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18327897", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0030691 Noc2p-Noc3p complex", "go_biological_process": "GO:0006270 DNA replication initiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VI82-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VIE6-1", "uniprot_id": [ { "id": "MCM10_DROME", "url": "https://www.uniprot.org/uniprot/Q9VIE6", "type": "external" } ], "mass": 86524.0, "length": 776, "protein_name": "Protein MCM10 homolog", "gene_name": "Mcm10", "organism": "Fruit fly", "refseq_name": "minichromosome maintenance 10", "refseq_ac": [ { "id": "NP_610097", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610097", "type": "external" } ], "gene_names_uniprotkb": "Mcm10; CG9241; Scim19", "gene_names_refseq": "CG9241; DmMCM10; Dmel\\CG9241; MCM10; Mcm10; Scim19; dMcm10; mcm10", "protein_names_uniprotkb": "Protein MCM10 homolog; Sensitized chromosome inheritance modifier 19", "protein_names_refseq": "CG9241-PA; Mcm10-PA; minichromosome maintenance 10; sensitized chromosome inheritance modifier 19", "tax_id": 7227, "disease": "immunodeficiency 80 (Disease Ontology:DOID:0061051)", "pathway": " (dme:Dmel_CG9241); (R-DME-176187); (R-DME-68962)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;12808023;18327897", "class_list": "", "function": "Proposed to be involved in DNA replication and to participate in the activation of the pre-replication complex (pre-RC). May be involved in chromosome condensation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95RC7", "ec_number_list": [], "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0008270 zinc ion binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus", "go_biological_process": "GO:0045931 positive regulation of mitotic cell cycle;GO:0006260 DNA replication;GO:0030261 chromosome condensation;GO:0006270 DNA replication initiation;GO:0042023 DNA endoreduplication", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VIE6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VIF0-1", "uniprot_id": [ { "id": "NOC2L_DROME", "url": "https://www.uniprot.org/uniprot/Q9VIF0", "type": "external" } ], "mass": 86631.0, "length": 766, "protein_name": "Nucleolar complex protein 2", "gene_name": "Noc2", "organism": "Fruit fly", "refseq_name": "nucleolar complex protein 2", "refseq_ac": [ { "id": "NP_610095", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610095", "type": "external" } ], "gene_names_uniprotkb": "Noc2; CG9246", "gene_names_refseq": "CG9246; Dmel\\CG9246; NOC2?; Noc2", "protein_names_uniprotkb": "Nucleolar complex protein 2", "protein_names_refseq": "CG9246-PA; Noc2-PA; nucleolar complex protein 2; nucleolar complex protein-2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9246); (R-DME-6804756)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18327897", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030690 Noc1p-Noc2p complex;GO:0030691 Noc2p-Noc3p complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0042273 ribosomal large subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VIF0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VIT0-1", "uniprot_id": [ { "id": "PCNA2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VIT0", "type": "external" } ], "mass": 28461.0, "length": 255, "protein_name": "DNA sliding clamp PCNA2", "gene_name": "PCNA2", "organism": "Fruit fly", "refseq_name": "proliferating cell nuclear antigen 2", "refseq_ac": [ { "id": "NP_609994", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609994", "type": "external" } ], "gene_names_uniprotkb": "PCNA2; CG10262", "gene_names_refseq": "CG10262; DmPCNA2; Dmel\\CG10262; PCNA2", "protein_names_uniprotkb": "DNA sliding clamp PCNA2; Proliferating cell nuclear antigen 2", "protein_names_refseq": "CG10262-PA; PCNA2-PA; proliferating cell nuclear antigen 2", "tax_id": 7227, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); mucositis (Disease Ontology:DOID:0080178); ataxia-telangiectasia-like disorder 2 (Disease Ontology:DOID:0081385); stomach cancer (Disease Ontology:DOID:10534); sciatic neuropathy (Disease Ontology:DOID:11446); osteoporosis (Disease Ontology:DOID:11476); Lewy body dementia (Disease Ontology:DOID:12217); leiomyoma (Disease Ontology:DOID:127); obstructive jaundice (Disease Ontology:DOID:13603); hypothyroidism (Disease Ontology:DOID:1459); nephroblastoma (Disease Ontology:DOID:2154); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); invasive ductal carcinoma (Disease Ontology:DOID:3008); liver cancer (Disease Ontology:DOID:3571); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dme:Dmel_CG10262)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;17087725", "class_list": "", "function": "Confers DNA tethering and processivity to DNA polymerases and other proteins (PubMed:17087725). Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of DNA replication by increasing the polymerases' processivity during elongation of the leading strand (PubMed:17087725). May function independently of PCNA during DNA repair (PubMed:17087725)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030337 DNA polymerase processivity factor activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0070182 DNA polymerase binding", "go_cellular_component": "GO:0043626 PCNA complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005694 chromosome", "go_biological_process": "GO:0006272 leading strand elongation;GO:0042542 response to hydrogen peroxide;GO:0006974 DNA damage response;GO:0006298 mismatch repair;GO:0006275 regulation of DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VIT0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VIW7-1", "uniprot_id": [ { "id": "RTCB_DROME", "url": "https://www.uniprot.org/uniprot/Q9VIW7", "type": "external" } ], "mass": 55916.0, "length": 506, "protein_name": "RNA-splicing ligase RtcB", "gene_name": "RtcB", "organism": "Fruit fly", "refseq_name": "RtcB RNA ligase", "refseq_ac": [ { "id": "NP_609965", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609965", "type": "external" } ], "gene_names_uniprotkb": "RtcB; CG9987", "gene_names_refseq": "CG9987; Dmel\\CG9987; RtcB; Rtcb", "protein_names_uniprotkb": "RNA-splicing ligase RtcB; 3'-phosphate/5'-hydroxy nucleic acid ligase; 6.5.1.8", "protein_names_refseq": "CG9987-PA; RtcB RNA ligase; RtcB-PA; RtcB-like", "tax_id": 7227, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (dme:Dmel_CG9987)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "3'-5' RNA ligase, catalytic subunit of the tRNA-splicing ligase complex (tRNA-LC), which is involved in the enzyme-dependent maturation of intron-containing pre-tRNAs. Functions downstream of the tRNA-splicing endonuclease that removes introns, ligating the two generated halves via phosphodiester bond formation. Also functions in non-canonical, spliceosome-independent, cytoplasmic splicing of mRNAs during the unfolded protein response (UPR)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.5.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.8", "type": "external" } ], "go_molecular_function": "GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0170057 RNA ligase (GTP) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0072669 tRNA-splicing ligase complex", "go_biological_process": "GO:0008033 tRNA processing;GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation;GO:2000237 positive regulation of tRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VIW7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VJ38-1", "uniprot_id": [ { "id": "RM13_DROME", "url": "https://www.uniprot.org/uniprot/Q9VJ38", "type": "external" } ], "mass": 21090.0, "length": 178, "protein_name": "Large ribosomal subunit protein uL13m", "gene_name": "mRpL13", "organism": "Fruit fly", "refseq_name": "mitochondrial ribosomal protein L13", "refseq_ac": [ { "id": "NP_523598", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523598", "type": "external" } ], "gene_names_uniprotkb": "mRpL13; CG10603", "gene_names_refseq": "CG10602; CG10603; Dmel\\CG10603; L13; MRPL13; anon-EST:fe3C4; mRpL13", "protein_names_uniprotkb": "Large ribosomal subunit protein uL13m; 39S ribosomal protein L13, mitochondrial; L13mt; MRP-L13", "protein_names_refseq": "CG10603-PA; anon-fast-evolving-3C4; mRpL13-PA; mitochondrial ribosomal protein L13", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10603); (R-DME-5389840); (R-DME-5419276); (R-DME-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7FNL2", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005840 ribosome", "go_biological_process": "GO:0017148 negative regulation of translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VJ38-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VJE4-1", "uniprot_id": [ { "id": "RPB11_DROME", "url": "https://www.uniprot.org/uniprot/Q9VJE4", "type": "external" } ], "mass": 13385.0, "length": 117, "protein_name": "DNA-directed RNA polymerase II subunit RPB11", "gene_name": "Polr2J", "organism": "Fruit fly", "refseq_name": "RNA polymerase II subunit J", "refseq_ac": [ { "id": "NP_609836", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609836", "type": "external" } ], "gene_names_uniprotkb": "Polr2J; CG6840; Rpb11", "gene_names_refseq": "BcDNA:GM15177; CG6840; Dmel\\CG6840; Polr2J; RPB11; Rpb11", "protein_names_uniprotkb": "DNA-directed RNA polymerase II subunit RPB11; DNA-directed RNA polymerase II 13.3 kDa polypeptide; DNA-directed RNA polymerase II subunit J; RNA polymerase II subunit B11", "protein_names_refseq": "CG6840-PA; Polr2J-PA; RNA polymerase II subunit J; Rpb11", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6840); (R-DME-112382); (R-DME-113418); (R-DME-5578749); (R-DME-674695); (R-DME-6781823); (R-DME-6782135); (R-DME-6782210); (R-DME-6796648); (R-DME-6807505); (R-DME-72086); (R-DME-72163); (R-DME-72165); (R-DME-72203); (R-DME-73776); (R-DME-73779); (R-DME-75953); (R-DME-75955); (R-DME-76042); (R-DME-77075); (R-DME-9018519); (R-DME-9770562)", "pathway_count": 22, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046983 protein dimerization activity;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005665 RNA polymerase II, core complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VJE4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VJI7-1", "uniprot_id": [ { "id": "Q9VJI7_DROME", "url": "https://www.uniprot.org/uniprot/Q9VJI7", "type": "external" } ], "mass": 12216.0, "length": 110, "protein_name": "U6 snRNA-associated Sm-like protein LSm7", "gene_name": "LSm7", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_001246045", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246045", "type": "external" } ], "gene_names_uniprotkb": "LSm7; BcDNA:RH73529; CG13277; Dmel\\CG13277; Dmel_CG13277; LSM7; Lsm7", "gene_names_refseq": "BcDNA:RH73529; CG13277; Dmel\\CG13277; LSM7; LSm7; Lsm7", "protein_names_uniprotkb": "U6 snRNA-associated Sm-like protein LSm7", "protein_names_refseq": "uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13277); (R-DME-430039)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0071013 catalytic step 2 spliceosome;GO:0071011 precatalytic spliceosome;GO:0071004 U2-type prespliceosome;GO:0005689 U12-type spliceosomal complex;GO:0005688 U6 snRNP", "go_biological_process": "GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VJI7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VJJ0-1", "uniprot_id": [ { "id": "Q9VJJ0_DROME", "url": "https://www.uniprot.org/uniprot/Q9VJJ0", "type": "external" } ], "mass": 22482.0, "length": 201, "protein_name": "Proteasome subunit beta", "gene_name": "Prosbeta4", "organism": "Fruit fly", "refseq_name": "proteasome beta4 subunit, isoform B", "refseq_ac": [ { "id": "NP_001260511", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260511", "type": "external" } ], "gene_names_uniprotkb": "Prosbeta4; 17331; Beta-4; CG17331; Dmel\\CG17331; Dmel_CG17331; GC17331; PSMB2; Pros beta4; Psmb2; beta-4; beta4", "gene_names_refseq": "17331; Beta-4; CG17331; Dmel\\CG17331; GC17331; PSMB2; Pros beta4; Prosbeta4; Psmb2; beta-4; beta4", "protein_names_uniprotkb": "Proteasome subunit beta", "protein_names_refseq": "CG17331-PB; Prosbeta4-PB; beta4; proteasome beta4 subunit, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17331); (R-DME-1169091); (R-DME-1234176); (R-DME-1236978); (R-DME-174084); (R-DME-174154); (R-DME-174178); (R-DME-174184); (R-DME-187577); (R-DME-195253); (R-DME-202424); (R-DME-209360); (R-DME-209406); (R-DME-209461); (R-DME-216167); (R-DME-2467813); (R-DME-2871837); (R-DME-350562); (R-DME-382556); (R-DME-432395); (R-DME-432524); (R-DME-432626); (R-DME-450408); (R-DME-4608870); (R-DME-4641257); (R-DME-4641258); (R-DME-5358346); (R-DME-538864); (R-DME-5607761); (R-DME-5607764); (R-DME-5610780); (R-DME-5610785); (R-DME-5632684); (R-DME-5658442); (R-DME-5676590); (R-DME-5689603); (R-DME-5689880); (R-DME-68867); (R-DME-68949); (R-DME-69017); (R-DME-69601); (R-DME-75815); (R-DME-8854050); (R-DME-8939236); (R-DME-8939902); (R-DME-8941858); (R-DME-8948751); (R-DME-8951664); (R-DME-9020702); (R-DME-9755511); (R-DME-9762114); (R-DME-983168); (R-DME-9907900); (R-DME-9912633); (R-DME-9929491); (R-DME-9932298); (R-DME-9954709)", "pathway_count": 57, "publication_count": 43, "publication_id_list": "10102270;10417378;10458606;10481010;10731132;11585911;12231619;12432393;12442174;12537568;12537572;12537573;12537574;12973300;15178801;15258584;15331761;16110336;16139204;16299518;16326393;16386907;16543224;16603629;16651542;16740475;16794082;17102630;17569856;17569867;17925225;18519643;18593878;19185492;25589440;26109356;26109357;7705656;8948598;9025065;9215627;9553105;9990853", "class_list": "", "function": "Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity., [UniProtKB, UniProtKB]; Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)., [UniProtKB, UniProtKB]; Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0019774 proteasome core complex, beta-subunit complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000502 proteasome complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0007618 mating", "synthesized_glycan_count": 0, "hit_score": 4.4, "record_id": "Q9VJJ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VJZ7-1", "uniprot_id": [ { "id": "RRP1L_DROME", "url": "https://www.uniprot.org/uniprot/Q9VJZ7", "type": "external" } ], "mass": 78996.0, "length": 687, "protein_name": "Ribosomal RNA processing protein 1 homolog", "gene_name": "Nnp-1", "organism": "Fruit fly", "refseq_name": "Nnp-1", "refseq_ac": [ { "id": "NP_651976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651976", "type": "external" } ], "gene_names_uniprotkb": "Nnp-1; CG12396", "gene_names_refseq": "CG12396; Dmel\\CG12396; NNP-1; Nnp-1; Nnp1; l(2)k07826; nnp-1", "protein_names_uniprotkb": "Ribosomal RNA processing protein 1 homolog; NNP-1 homolog; RRP1-like protein", "protein_names_refseq": "CG12396-PA; Nnp-1-PA; Nnp-1; Nnp1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12396)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;18327897", "class_list": "", "function": "May be involved in the generation of 28S rRNA., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6AWH7", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome;GO:0030688 preribosome, small subunit precursor", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VJZ7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VKB4-1", "uniprot_id": [ { "id": "RPF1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VKB4", "type": "external" } ], "mass": 45999.0, "length": 394, "protein_name": "Probable ribosome production factor 1", "gene_name": "CG6712", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_477479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477479", "type": "external" } ], "gene_names_uniprotkb": "CG6712", "gene_names_refseq": "CG6712; Dmel\\CG6712; ORF2", "protein_names_uniprotkb": "Probable ribosome production factor 1; Ribosome biogenesis protein RPF1", "protein_names_refseq": "CG6712-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6712)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "May be required for ribosome biogenesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0042134 rRNA primary transcript binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0042254 ribosome biogenesis;GO:0000460 maturation of 5.8S rRNA;GO:0000470 maturation of LSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VKB4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VKB9-1", "uniprot_id": [ { "id": "RBGPR_DROME", "url": "https://www.uniprot.org/uniprot/Q9VKB9", "type": "external" } ], "mass": 151008.0, "length": 1341, "protein_name": "Rab3 GTPase-activating protein non-catalytic subunit", "gene_name": "Rab3-GAP", "organism": "Fruit fly", "refseq_name": "Rab3 GTPase activating protein, isoform A", "refseq_ac": [ { "id": "NP_609544", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609544", "type": "external" } ], "gene_names_uniprotkb": "Rab3-GAP; CG7061; Rab3GAP2", "gene_names_refseq": "BcDNA:LD23336; CG7061; Dmel\\CG7061; Rab3-GAP; Rab3GAP2; rab3-GAP", "protein_names_uniprotkb": "Rab3 GTPase-activating protein non-catalytic subunit; Rab3 GTPase-activating protein regulatory subunit", "protein_names_refseq": "CG7061-PA; Rab3 GTPase activating protein, isoform A; Rab3-GAP-PA; rab3-GAP", "tax_id": 7227, "disease": "Warburg micro syndrome (Disease Ontology:DOID:0060237); Warburg micro syndrome 2 (Disease Ontology:DOID:0110717); Martsolf syndrome (Disease Ontology:DOID:0111586)", "pathway": " (dme:Dmel_CG7061); (R-DME-6811436); (R-DME-8876198)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10731132;10731138;10798391;12537572;18327897;21338884;32248620", "class_list": "", "function": "Regulatory subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of Rab3-GAP and Rab3GAP1, which has both GTPase-activating protein (GAP) activity towards Rab3, and guanine nucleotide exchange factor (GEF) activity towards Rab18 (PubMed:21338884, PubMed:32248620). As part of the Rab3GAP complex, required for the rapid induction and sustained expression of synaptic homeostasis at the neuromuscular junction (NMJ) (PubMed:21338884). Also participates in the regulation of autophagy in tissues such as larval fat cells and adult muscles (PubMed:32248620). The Rab3GAP complex, acts as a GAP for Rab3 by converting active Rab3-GTP to the inactive form Rab3-GDP (PubMed:21338884). At the neuromuscular junction (NMJ), forms a presynaptic signaling mechanism with Rab3 that regulates progression of synaptic homeostasis at a late stage of vesicle release (PubMed:21338884). Within this mechanism Rab3-GTP acts, directly or indirectly, to inhibit the progression of synaptic homeostasis, and Rab3-GAP functions to inactivate this action of Rab3-GTP (PubMed:21338884). The Rab3GAP complex, acts as a GEF for Rab18 by promoting the conversion of inactive Rab18-GDP to the active form Rab18-GTP (By similarity). Regulates autophagy as part of a Rab3GAP-Rab18 module (PubMed:32248620). Once Rab18 is activated by the GEF Rab3GAP complex, the Rab3GAP-Rab18 module localizes to autophagosomes, and regulates autolysosome formation and maturation together with the Rab18 interacting effector, the PI3K/Vps34 Complex I (PubMed:32248620)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7KMI4;Q7KTD8;Q9VKC0;Q9Y0Z3", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005886 plasma membrane;GO:0030424 axon;GO:0045202 synapse;GO:0005776 autophagosome", "go_biological_process": "GO:0097051 establishment of protein localization to endoplasmic reticulum membrane;GO:0043087 regulation of GTPase activity;GO:0043547 positive regulation of GTPase activity;GO:0016236 macroautophagy;GO:0046928 regulation of neurotransmitter secretion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9VKB9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VKG9-1", "uniprot_id": [ { "id": "SPZ4_DROME", "url": "https://www.uniprot.org/uniprot/Q9VKG9", "type": "external" } ], "mass": 65755.0, "length": 597, "protein_name": "Protein spaetzle 4", "gene_name": "spz4", "organism": "Fruit fly", "refseq_name": "spatzle 4", "refseq_ac": [ { "id": "NP_609504", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609504", "type": "external" } ], "gene_names_uniprotkb": "spz4; CG14928", "gene_names_refseq": "CG14928; CT34755; Dmel\\CG14928; Spz-4; Spz4; spz4", "protein_names_uniprotkb": "Protein spaetzle 4; Protein spatzle 4", "protein_names_refseq": "CG14928-PB; spatzle 4; spatzle4; spz4-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14928)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;11536362;12537572", "class_list": "", "function": "", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D0IQH0", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity;GO:0005121 Toll binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0045087 innate immune response;GO:0021556 central nervous system formation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VKG9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VKM1-1", "uniprot_id": [ { "id": "PIWI_DROME", "url": "https://www.uniprot.org/uniprot/Q9VKM1", "type": "external" } ], "mass": 97177.0, "length": 843, "protein_name": "Protein piwi", "gene_name": "piwi", "organism": "Fruit fly", "refseq_name": "P-element induced wimpy testis, isoform B", "refseq_ac": [ { "id": "NP_001285825", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285825", "type": "external" } ], "gene_names_uniprotkb": "piwi; CG6122; Dmel\\CG6122; Dmel_CG6122; PIWI; Piwi", "gene_names_refseq": "CG6122; Dmel\\CG6122; PIWI; Piwi; piwi", "protein_names_uniprotkb": "Protein piwi; 3.1.26.-; Protein P-element induced wimpy testis", "protein_names_refseq": "CG6122-PB; P-element induced wimpy testis, isoform B; piwi-PB", "tax_id": 7227, "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (dme:Dmel_CG6122)", "pathway_count": 1, "publication_count": 46, "publication_id_list": "10631171;10731132;12537568;12537572;12537573;12537574;15817569;16110336;16882972;16949822;17346786;17569856;17569867;17875665;17952056;19377467;19395009;19812547;20966047;21186352;21447556;21831924;22065765;22997235;23159368;23297219;23392609;23392610;23434410;23913921;23913922;24906153;25589440;26109356;26109357;26212455;26472911;26494711;26808625;28472469;29531043;29735528;31368590;31384064;9199372;9851978", "class_list": "", "function": "Acts via the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:15817569, PubMed:17346786, PubMed:26808625). Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (PubMed:16882972). In ovarian somatic cells, mediates silencing of transposable elements at the transcriptional level in a mael-dependent manner (PubMed:23159368, PubMed:28472469). Involved in silencing of long terminal repeat (LTR) retrotransposons in male germline (PubMed:15817569). In testis, regulates spermatogenesis together with Tudor-SN (PubMed:26808625). In germ cells, mediates silencing at both transcriptional and post-transcriptional levels and is involved in the maintenance of populations of primary and secondary piRNAs. Piwi-mediated transcriptional silencing is accompanied by the formation of His3 trimethylated on 'Lys-10' (H3K9me3) associated euchromatin and heterochromatin (PubMed:23392610, PubMed:23434410, PubMed:24906153). In ovary, associates predominantly with antisense piRNAs that contain uridine at their 5' end. Association with sense piRNAs is also observed but to a lesser extent. Mediates a somatic signaling mechanism required for the maintenance of germline stem cells to produce and maintain a daughter germline stem cell (PubMed:10631171, PubMed:16949822, PubMed:9199372, PubMed:9851978). It is not essential for the further differentiation of the committed daughter cell (PubMed:9851978). Acts cell autonomously to promote germline stem cell division (PubMed:10631171, PubMed:9851978). Its role in stem cell maintenance does not seem to require nuclear localization. Required maternally for the posterior localization of osk and vas and for pole cell formation during oogenesis and early embryogenesis (PubMed:16949822). Together with Hop and Hsp83, mediates canalization, also known as developmental robustness, likely via epigenetic silencing of existing genetic variants and suppression of transposon-induced new genetic variation (PubMed:21186352). Shows RNA cleavage activity, although is not required for any of its known functions (PubMed:16882972, PubMed:23297219, PubMed:9199372). In the ovaries, forms a complex with nxf2, Panx and Nxt1 which acts as effectors of cotranscriptional transposon silencing (PubMed:31368590, PubMed:31384064)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 24, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C0PTU6;K7WKS7;K7WKT2;K7WQ39;K7WS94;K7XHZ2;L0CPR8;L0CPS4;L0CQ04;L0CR36;L0CRH9;L0CRI5;L0CRU0;O96674;O96675;Q6NNZ4;Q6NP34", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0031490 chromatin DNA binding;GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0048133 male germ-line stem cell asymmetric division;GO:0007283 spermatogenesis;GO:0031047 regulatory ncRNA-mediated gene silencing;GO:0048477 oogenesis;GO:0034587 piRNA processing", "synthesized_glycan_count": 0, "hit_score": 4.7, "record_id": "Q9VKM1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VKY1-1", "uniprot_id": [ { "id": "LIX1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VKY1", "type": "external" } ], "mass": 30698.0, "length": 268, "protein_name": "Protein limb expression 1 homolog", "gene_name": "lft", "organism": "Fruit fly", "refseq_name": "lowfat, isoform B", "refseq_ac": [ { "id": "NP_001188775", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001188775", "type": "external" } ], "gene_names_uniprotkb": "lft; CG13139", "gene_names_refseq": "CG13139; Dmel\\CG13139; LFT; Lft; lft", "protein_names_uniprotkb": "Protein limb expression 1 homolog; lowfat", "protein_names_refseq": "CG13139-PB; Low fat; lft-PB; lowfat, isoform B; lowfat", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13139); (R-DME-390150)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10731132;12537572;12941274;14502295;17174922;19710173;21379328", "class_list": "", "function": "Component of the Fat (ft) signaling pathway that functions in normal development of various organs such as the wing and leg (PubMed:19710173, PubMed:21379328). In developing imaginal disks, involved in regulating both the protein levels and apical localization of ft and ds (PubMed:19710173). Involved in establishing planar cell polarity (PCP) along the anterior-posterior axis of the wing (the early Fz signaling event), probably by acting upstream of ds and ft to regulate Fz activity (PubMed:21379328)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016324 apical plasma membrane;GO:0035003 subapical complex", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0007476 imaginal disc-derived wing morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9VKY1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VL21-1", "uniprot_id": [ { "id": "Q9VL21_DROME", "url": "https://www.uniprot.org/uniprot/Q9VL21", "type": "external" } ], "mass": 26573.0, "length": 241, "protein_name": "LIM zinc-binding domain-containing protein", "gene_name": "Dmel\\CG5708", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform C", "refseq_ac": [ { "id": "NP_001285799", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285799", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG5708; CG5708; Dmel_CG5708", "gene_names_refseq": "CG5708; Dmel\\CG5708", "protein_names_uniprotkb": "LIM zinc-binding domain-containing protein", "protein_names_refseq": "CG5708-PC; uncharacterized protein, isoform C", "tax_id": 7227, "disease": "anencephaly (Disease Ontology:DOID:0060668)", "pathway": " (dme:Dmel_CG5708)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0035218 leg disc development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VL21-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VL31-1", "uniprot_id": [ { "id": "RIP_DROME", "url": "https://www.uniprot.org/uniprot/Q9VL31", "type": "external" } ], "mass": 23252.0, "length": 197, "protein_name": "RIP-like protein", "gene_name": "Ripalpha", "organism": "Fruit fly", "refseq_name": "RPA-interacting protein alpha", "refseq_ac": [ { "id": "NP_609351", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609351", "type": "external" } ], "gene_names_uniprotkb": "Ripalpha; CG18145", "gene_names_refseq": "CG18145; Dmel\\CG18145; Ripalpha; Tes83; dRIPalpha", "protein_names_uniprotkb": "RIP-like protein; RIP-alpha", "protein_names_refseq": "CG18145-PA; RPA-interacting protein alpha; Ripalpha-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18145)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;15917496", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4PKP8", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VL31-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VL32-1", "uniprot_id": [ { "id": "SUR_DROME", "url": "https://www.uniprot.org/uniprot/Q9VL32", "type": "external" } ], "mass": 248044.0, "length": 2223, "protein_name": "ATP-binding cassette sub-family C member Sur", "gene_name": "Sur", "organism": "Fruit fly", "refseq_name": "sulfonylurea receptor", "refseq_ac": [ { "id": "NP_001334732", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334732", "type": "external" } ], "gene_names_uniprotkb": "Sur; CG5772", "gene_names_refseq": "BEST:CK00325; CG5772; CK00325; DSur; DmSUR; Dme_CG5772; Dmel\\CG5772; Dsur; SUR; Sur; dSUR; dSur; dsur; sur", "protein_names_uniprotkb": "ATP-binding cassette sub-family C member Sur; Dsur; Sulfonylurea receptor", "protein_names_refseq": "CG5772-PC; Sur-PC; sulfonyl urea receptor; sulfonylurea receptor; sulphonylurea receptor", "tax_id": 7227, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); stroke (Disease Ontology:DOID:0051061); cardiac arrest (Disease Ontology:DOID:0060319); transient neonatal diabetes mellitus (Disease Ontology:DOID:0060334); hypertrichotic osteochondrodysplasia Cantu type (Disease Ontology:DOID:0060569); permanent neonatal diabetes mellitus (Disease Ontology:DOID:0060639); transient neonatal diabetes mellitus 2 (Disease Ontology:DOID:0061174); familial hyperinsulinemic hypoglycemia 1 (Disease Ontology:DOID:0070219); intellectual disability and myopathy syndrome (Disease Ontology:DOID:0070600); Parkinsonism (Disease Ontology:DOID:0080855); dilated cardiomyopathy 1O (Disease Ontology:DOID:0110451); leucine-sensitive hypoglycemia of infancy (Disease Ontology:DOID:0112262); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); dilated cardiomyopathy (Disease Ontology:DOID:12930); hyperinsulinemic hypoglycemia (Disease Ontology:DOID:13317); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); hyperinsulinism (Disease Ontology:DOID:2018); middle cerebral artery infarction (Disease Ontology:DOID:3525); brain edema (Disease Ontology:DOID:4724); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (dme:Dmel_CG5772); (R-DME-1296025); (R-DME-382556); (R-DME-422356); (R-DME-5578775)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "10506204;10731132;12537572;16882722;22105623", "class_list": "", "function": "May function as regulatory subunit of ATP-sensitive potassium channels (KATP) and form KATP channels with a member of the ATP-sensitive inward rectifier potassium channel family (By similarity). May also have channel activity by itself (in vitro). May protect the heart during hypoxia. May protect against heart failure under conditions of tachycardic stress., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 23, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1W5PZ45;Q9U6Z2", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140359 ABC-type transporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VL32-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VL52-1", "uniprot_id": [ { "id": "SOYB_DROME", "url": "https://www.uniprot.org/uniprot/Q9VL52", "type": "external" } ], "mass": 168480.0, "length": 1476, "protein_name": "Putative ATP-dependent RNA helicase SoYb", "gene_name": "SoYb", "organism": "Fruit fly", "refseq_name": "sister of Yb, isoform C", "refseq_ac": [ { "id": "NP_001245959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245959", "type": "external" } ], "gene_names_uniprotkb": "SoYb; CG31755", "gene_names_refseq": "CG31755; CG5831; Dmel\\CG31755; SoYb; soyb", "protein_names_uniprotkb": "Putative ATP-dependent RNA helicase SoYb; 3.6.4.13; Sister of Yb", "protein_names_refseq": "CG31755-PC; SoYb-PC; sister of Yb, isoform C; sister of Yb", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31755)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;21863019", "class_list": "", "function": "Involved in primary piRNA biogenesis in germline cells., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E0R964", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.-.-.-", "type": "external" }, { "id": "5.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0070725 Yb body", "go_biological_process": "GO:0042078 germ-line stem cell division;GO:0140990 primary piRNA processing;GO:0140965 secondary piRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VL52-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VLJ9-1", "uniprot_id": [ { "id": "RM51_DROME", "url": "https://www.uniprot.org/uniprot/Q9VLJ9", "type": "external" } ], "mass": 20233.0, "length": 174, "protein_name": "Large ribosomal subunit protein mL51", "gene_name": "mRpL51", "organism": "Fruit fly", "refseq_name": "mitochondrial ribosomal protein L51", "refseq_ac": [ { "id": "NP_609239", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609239", "type": "external" } ], "gene_names_uniprotkb": "mRpL51; CG13098", "gene_names_refseq": "CG13098; Dmel\\CG13098; MRP-L51; mRpL51", "protein_names_uniprotkb": "Large ribosomal subunit protein mL51; 39S ribosomal protein L51, mitochondrial; L51mt; MRP-L51", "protein_names_refseq": "CG13098-PA; mRpL51-PA; mitochondrial ribosomal protein L51", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13098); (R-DME-5389840); (R-DME-5419276); (R-DME-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q961D8", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005761 mitochondrial ribosome", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VLJ9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VLP9-1", "uniprot_id": [ { "id": "SR5A3_DROME", "url": "https://www.uniprot.org/uniprot/Q9VLP9", "type": "external" } ], "mass": 38034.0, "length": 326, "protein_name": "Polyprenal reductase", "gene_name": "CG7840", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_609203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609203", "type": "external" } ], "gene_names_uniprotkb": "CG7840", "gene_names_refseq": "CG7840; Dmel\\CG7840; cg7840", "protein_names_uniprotkb": "Polyprenal reductase; 1.3.1.94", "protein_names_refseq": "CG7840-PA; uncharacterized protein", "tax_id": 7227, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); Kahrizi syndrome (Disease Ontology:DOID:0050807); congenital disorder of glycosylation Iq (Disease Ontology:DOID:0080568)", "pathway": " (dme:Dmel_CG7840); (R-DME-193048); (R-DME-446199)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;16951084;19126864", "class_list": "", "function": "Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol (By similarity). Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism (By similarity). Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0ANR0;A0ANR1;A0ANR2;A0ANR3;A0ANR5;Q8MR21", "ec_number_list": [ { "id": "1.3.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.94", "type": "external" } ], "go_molecular_function": "GO:0047751 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity;GO:0160198 polyprenal reductase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0043048 dolichyl monophosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VLP9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VLR5-1", "uniprot_id": [ { "id": "TCP4_DROME", "url": "https://www.uniprot.org/uniprot/Q9VLR5", "type": "external" } ], "mass": 12189.0, "length": 110, "protein_name": "RNA polymerase II transcriptional coactivator", "gene_name": "Ssb-c31a", "organism": "Fruit fly", "refseq_name": "single stranded-binding protein c31A", "refseq_ac": [ { "id": "NP_477136", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477136", "type": "external" } ], "gene_names_uniprotkb": "Ssb-c31a; CG8396", "gene_names_refseq": "C31A; CG8396; Dmel\\CG8396; PC4-like; Ssb-C31a; Ssb-c31a; c31A; p11", "protein_names_uniprotkb": "RNA polymerase II transcriptional coactivator; p11", "protein_names_refseq": "CG8396-PA; Ssb-c31a-PA; single stranded-binding protein c31A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8396)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;8559667", "class_list": "", "function": "General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. Binds single-stranded DNA (By similarity). Binds specifically to the NssBF element, a short nucleotide sequence of the 1731 retrotransposon, to repress promoter activity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24026;Q4V3U5", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VLR5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VLU4-1", "uniprot_id": [ { "id": "SP28D_DROME", "url": "https://www.uniprot.org/uniprot/Q9VLU4", "type": "external" } ], "mass": 59350.0, "length": 536, "protein_name": "Serine protease inhibitor 28Dc", "gene_name": "Spn28Dc", "organism": "Fruit fly", "refseq_name": "serpin 28Dc", "refseq_ac": [ { "id": "NP_609172", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609172", "type": "external" } ], "gene_names_uniprotkb": "Spn28Dc; CG7219; Spn28D", "gene_names_refseq": "CG7219; Dm-Spn28D; Dmel\\CG7219; Spn28Dc; Spn28D; spn28D", "protein_names_uniprotkb": "Serine protease inhibitor 28Dc; Serpin 28Dc; Serpin-28D", "protein_names_refseq": "CG7219-PA; Dm-serpin-28D; Serpin-28D; Serpin28Dc; Spn28Dc-PA; serpin 28Dc; serpin 28D", "tax_id": 7227, "disease": "peripheral artery disease (Disease Ontology:DOID:0050830); sleep apnea (Disease Ontology:DOID:0050847); obstructive sleep apnea (Disease Ontology:DOID:0050848); glomerulosclerosis (Disease Ontology:DOID:0050851); renal fibrosis (Disease Ontology:DOID:0050855); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); small intestine carcinoid neuroendocrine tumor (Disease Ontology:DOID:0050925); stroke (Disease Ontology:DOID:0051061); ischemic colitis (Disease Ontology:DOID:0060181); chemical colitis (Disease Ontology:DOID:0060186); ileitis (Disease Ontology:DOID:0060189); thrombosis (Disease Ontology:DOID:0060903); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); peeling skin syndrome 5 (Disease Ontology:DOID:0070524); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Coronavirus infectious disease (Disease Ontology:DOID:0080599); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); Graves ophthalmopathy (Disease Ontology:DOID:0081120); corticosteroid-binding globulin deficiency (Disease Ontology:DOID:0090030); autosomal recessive nonsyndromic deafness 91 (Disease Ontology:DOID:0110536); platelet-type bleeding disorder 10 (Disease Ontology:DOID:0111046); pleurisy (Disease Ontology:DOID:10247); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); disseminated intravascular coagulation (Disease Ontology:DOID:11247); adult respiratory distress syndrome (Disease Ontology:DOID:11394); sciatic neuropathy (Disease Ontology:DOID:11446); polycystic ovary syndrome (Disease Ontology:DOID:11612); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); portal vein thrombosis (Disease Ontology:DOID:11695); diabetic angiopathy (Disease Ontology:DOID:11713); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); Graves' disease (Disease Ontology:DOID:12361); retinopathy of prematurity (Disease Ontology:DOID:13025); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); uveitis (Disease Ontology:DOID:13141); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); Behcet's disease (Disease Ontology:DOID:13241); alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372); familial combined hyperlipidemia (Disease Ontology:DOID:13809); familial hypercholesterolemia (Disease Ontology:DOID:13810); polyneuropathy (Disease Ontology:DOID:1389); thoracic aortic aneurysm (Disease Ontology:DOID:14004); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); toxic shock syndrome (Disease Ontology:DOID:14115); cystic fibrosis (Disease Ontology:DOID:1485); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); retinal vein occlusion (Disease Ontology:DOID:1727); pancreatic cancer (Disease Ontology:DOID:1793); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); arteriosclerosis (Disease Ontology:DOID:2349); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); thrombophilia (Disease Ontology:DOID:2452); asthma (Disease Ontology:DOID:2841); acute pancreatitis (Disease Ontology:DOID:2913); glomerulonephritis (Disease Ontology:DOID:2921); severe acute respiratory syndrome (Disease Ontology:DOID:2945); familial Mediterranean fever (Disease Ontology:DOID:2987); high grade glioma (Disease Ontology:DOID:3070); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); neurilemmoma (Disease Ontology:DOID:3192); coronary artery disease (Disease Ontology:DOID:3393); Noonan syndrome (Disease Ontology:DOID:3490); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); aortic aneurysm (Disease Ontology:DOID:3627); pulmonary fibrosis (Disease Ontology:DOID:3770); placental insufficiency (Disease Ontology:DOID:3891); lung adenocarcinoma (Disease Ontology:DOID:3910); liver disease (Disease Ontology:DOID:409); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); rhinitis (Disease Ontology:DOID:4483); liver cirrhosis (Disease Ontology:DOID:5082); ureteral obstruction (Disease Ontology:DOID:5199); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); pneumonia (Disease Ontology:DOID:552); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); myocardial infarction (Disease Ontology:DOID:5844); uveal melanoma (Disease Ontology:DOID:6039); pulmonary hypertension (Disease Ontology:DOID:6432); hematopoietic system disease (Disease Ontology:DOID:74); muscular atrophy (Disease Ontology:DOID:767); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); hyperthyroidism (Disease Ontology:DOID:7998); osteoarthritis (Disease Ontology:DOID:8398); polycythemia (Disease Ontology:DOID:8432); lung disease (Disease Ontology:DOID:850); vasculitis (Disease Ontology:DOID:865); diabetic retinopathy (Disease Ontology:DOID:8947); amyloidosis (Disease Ontology:DOID:9120); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG7219)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;18801354;22227521", "class_list": "", "function": "Serine protease inhibitor which is required for pupal viability and plays an essential role in regulating the melanization reaction (PubMed:18801354, PubMed:22227521). Inhibits spontaneous melanization and appears to be involved in the melanization immune response to physical wounding in larvae and adults (PubMed:18801354, PubMed:22227521). Acts by negatively regulating the Hayan-phenoloxidase (PPO1) cascade in the hemolymph and possibly the trachea (PubMed:18801354, PubMed:22227521). May function by controlling the initial release of the activated form of PPO1, phenoloxidase (PO) and thus maintains PO availability for processes such as wound response and pigmentation (PubMed:18801354)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 102, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0009611 response to wounding;GO:0045861 negative regulation of proteolysis;GO:0042438 melanin biosynthetic process;GO:0002376 immune system process;GO:0035009 negative regulation of melanization defense response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VLU4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VLU6-1", "uniprot_id": [ { "id": "SDHF4_DROME", "url": "https://www.uniprot.org/uniprot/Q9VLU6", "type": "external" } ], "mass": 13323.0, "length": 118, "protein_name": "Succinate dehydrogenase assembly factor 4, mitochondrial", "gene_name": "Sirup", "organism": "Fruit fly", "refseq_name": "Starvation-upregulated protein, isoform C", "refseq_ac": [ { "id": "NP_001285734", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285734", "type": "external" } ], "gene_names_uniprotkb": "Sirup; CG7224; Sdhaf4", "gene_names_refseq": "BcDNA:GH18422; CG7224; Dmel\\CG7224; Sdhaf4; Sirup; anon-EST:Posey12; dSdhaf4", "protein_names_uniprotkb": "Succinate dehydrogenase assembly factor 4, mitochondrial; SDH assembly factor 4; SDHAF4; Starvation-upregulated protein", "protein_names_refseq": "CG7224-PC; Sirup-PC; Starvation-upregulated protein, isoform C; starvation-upregulated protein", "tax_id": 7227, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); candidiasis (Disease Ontology:DOID:1508)", "pathway": " (dme:Dmel_CG7224); (R-DME-9854311)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537572;24954416", "class_list": "", "function": "Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954416). Binds to the flavoprotein subunit SdhA in its FAD-bound form, blocking the generation of excess reactive oxygen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SdhB into the SDH catalytic dimer (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0034614 cellular response to reactive oxygen species;GO:1904231 positive regulation of succinate dehydrogenase activity;GO:0034553 mitochondrial respiratory chain complex II assembly;GO:0045333 cellular respiration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VLU6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VLV5-1", "uniprot_id": [ { "id": "RUXE_DROME", "url": "https://www.uniprot.org/uniprot/Q9VLV5", "type": "external" } ], "mass": 11096.0, "length": 94, "protein_name": "Probable small nuclear ribonucleoprotein E", "gene_name": "SmE", "organism": "Fruit fly", "refseq_name": "small ribonucleoprotein particle protein SmE", "refseq_ac": [ { "id": "NP_609162", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609162", "type": "external" } ], "gene_names_uniprotkb": "SmE; CG18591", "gene_names_refseq": "BcDNA:GM19936; CG18591; Dmel\\CG18591; E-Sm; E; SmE; dE; snRNPE", "protein_names_uniprotkb": "Probable small nuclear ribonucleoprotein E; Sm protein E; Sm-E; SmE; snRNP-E", "protein_names_refseq": "CG18591-PA; SmE-PA; small ribonucleoprotein particle protein SmE; snRNPE", "tax_id": 7227, "disease": "lupus nephritis (Disease Ontology:DOID:0080162); hypotrichosis 1 (Disease Ontology:DOID:0110698); hypotrichosis 11 (Disease Ontology:DOID:0110708); prostate cancer (Disease Ontology:DOID:10283); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); neuroblastoma (Disease Ontology:DOID:769); nasopharynx carcinoma (Disease Ontology:DOID:9261); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (dme:Dmel_CG18591); (R-DME-111367); (R-DME-72163); (R-DME-72165); (R-DME-73856); (R-DME-77588); (R-DME-9770562); (R-DME-9943411)", "pathway_count": 8, "publication_count": 3, "publication_id_list": "10731132;12537572;18621711", "class_list": "", "function": "Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0036261 7-methylguanosine cap hypermethylation;GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome;GO:0071045 nuclear histone mRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VLV5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VLV7-1", "uniprot_id": [ { "id": "SPZ3_DROME", "url": "https://www.uniprot.org/uniprot/Q9VLV7", "type": "external" } ], "mass": 67126.0, "length": 611, "protein_name": "Protein spaetzle 3", "gene_name": "spz3", "organism": "Fruit fly", "refseq_name": "spatzle 3", "refseq_ac": [ { "id": "NP_609160", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609160", "type": "external" } ], "gene_names_uniprotkb": "spz3; CG7104", "gene_names_refseq": "CG14533; CG7104; CT21967; CT34263; Dmel\\CG7104; Spz-3; Spz3; spz3", "protein_names_uniprotkb": "Protein spaetzle 3; Protein spatzle 3", "protein_names_refseq": "CG7104-PA; Spz3; spatzle 3; spatzle3; spz3-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7104)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;11536362;12537572;24662564", "class_list": "", "function": "Neurotrophin which may function as a ligand to the Toll-related receptor Tollo. Involved in a Tollo and JNK signaling pathway that positively regulates neuromuscular junction (NMJ) growth in presynaptic motorneurons. May function by activating Tollo to promote the phosphorylation of JNK., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8WTE9", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity;GO:0005121 Toll binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0045087 innate immune response;GO:0021556 central nervous system formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VLV7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VM46-1", "uniprot_id": [ { "id": "SEM1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VM46", "type": "external" } ], "mass": 9385.0, "length": 79, "protein_name": "Probable 26S proteasome complex subunit sem1", "gene_name": "Sem1", "organism": "Fruit fly", "refseq_name": "suppressor of exocyst mutations 1", "refseq_ac": [ { "id": "NP_652555", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_652555", "type": "external" } ], "gene_names_uniprotkb": "Sem1; CG13779", "gene_names_refseq": "BcDNA:RH34416; CG13779; DSS1; Dmel\\CG13779; Sem1p; Sem1; dmdss1; dss1; sem1", "protein_names_uniprotkb": "Probable 26S proteasome complex subunit sem1", "protein_names_refseq": "CG13779-PA; Sem1 ortholog; Sem1-PA; suppressor of exocyst mutations 1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13779); (R-DME-209360); (R-DME-209406); (R-DME-209461); (R-DME-216167); (R-DME-432395); (R-DME-432524); (R-DME-432626); (R-DME-538864)", "pathway_count": 9, "publication_count": 36, "publication_id_list": "10102270;10417378;10458606;10481010;10731132;11585911;12231619;12432393;12442174;12537569;12537572;12973300;15178801;15258584;15331761;16139204;16299518;16326393;16386907;16543224;16603629;16651542;16740475;16794082;17102630;17925225;18327897;18519643;18593878;19185492;7705656;8948598;9025065;9215627;9553105;9990853", "class_list": "", "function": "Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000502 proteasome complex;GO:0008541 proteasome regulatory particle, lid subcomplex", "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000724 double-strand break repair via homologous recombination;GO:0043248 proteasome assembly", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "Q9VM46-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VM51-1", "uniprot_id": [ { "id": "MME1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VM51", "type": "external" } ], "mass": 32396.0, "length": 299, "protein_name": "Mitochondrial magnesium exporter 1", "gene_name": "MME1", "organism": "Fruit fly", "refseq_name": "mitochondrial magnesium exporter 1", "refseq_ac": [ { "id": "NP_609093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609093", "type": "external" } ], "gene_names_uniprotkb": "MME1; CG3476", "gene_names_refseq": "CG3476; Dmel\\CG3476; MME1; dMme1", "protein_names_uniprotkb": "Mitochondrial magnesium exporter 1", "protein_names_refseq": "CG3476-PA; MME1-PA; mitochondrial magnesium exporter 1", "tax_id": 7227, "disease": "carnitine-acylcarnitine translocase deficiency (Disease Ontology:DOID:0111585); lipid metabolism disorder (Disease Ontology:DOID:3146)", "pathway": " (dme:Dmel_CG3476)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;26462626", "class_list": "", "function": "Mediates efflux of magnesium ions from mitochondria, suggesting a role in magnesium homeostasis., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015095 magnesium ion transmembrane transporter activity;GO:0015227 O-acyl-L-carnitine transmembrane transporter activity", "go_cellular_component": "GO:0005740 mitochondrial envelope;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006839 mitochondrial transport;GO:0010961 intracellular magnesium ion homeostasis;GO:1902603 carnitine transmembrane transport;GO:1990616 magnesium ion export from mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VM51-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VM64-1", "uniprot_id": [ { "id": "IHOG_DROME", "url": "https://www.uniprot.org/uniprot/Q9VM64", "type": "external" } ], "mass": 97846.0, "length": 886, "protein_name": "Interference hedgehog", "gene_name": "ihog", "organism": "Fruit fly", "refseq_name": "interference hedgehog", "refseq_ac": [ { "id": "NP_609085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609085", "type": "external" } ], "gene_names_uniprotkb": "ihog; CG9211", "gene_names_refseq": "CG9211; CT26314; Dmel\\CG9211; IHOG; Ihog; iHog; ihog", "protein_names_uniprotkb": "Interference hedgehog", "protein_names_refseq": "CG9211-PA; ihog-PA; interference hedgehog", "tax_id": 7227, "disease": "holoprosencephaly 11 (Disease Ontology:DOID:0110877)", "pathway": " (dme:Dmel_CG9211); (R-DME-209214); (R-DME-209338); (R-DME-447043); (R-DME-6798695)", "pathway_count": 5, "publication_count": 23, "publication_id_list": "10731132;12537569;12537572;12663920;14523402;14597665;14614827;14636583;15300262;15563523;15592457;15598741;15616566;15875013;16041759;16120803;16630821;17077139;17182028;19349973;8898207;8906787;8906794", "class_list": "", "function": "Mediates response to the active Hedgehog (Hh) protein signal in embryos, functioning upstream or at the level of patched (ptc)., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "C0PTX1;Q2XY56", "ec_number_list": [], "go_molecular_function": "GO:0097108 hedgehog family protein binding;GO:0008201 heparin binding;GO:0015026 coreceptor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0030424 axon;GO:0035230 cytoneme", "go_biological_process": "GO:0034109 homotypic cell-cell adhesion;GO:0048749 compound eye development;GO:0098609 cell-cell adhesion;GO:0007379 segment specification;GO:0007224 smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q9VM64-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VM90-1", "uniprot_id": [ { "id": "SBKH_DROME", "url": "https://www.uniprot.org/uniprot/Q9VM90", "type": "external" } ], "mass": 52419.0, "length": 456, "protein_name": "Serine/threonine-protein kinase meng-po", "gene_name": "meng", "organism": "Fruit fly", "refseq_name": "meng-po, isoform B", "refseq_ac": [ { "id": "NP_001285688", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285688", "type": "external" } ], "gene_names_uniprotkb": "meng; CG11221; MP; PKN", "gene_names_refseq": "CG11221; Dmel\\CG11221; Meng-Po; PKN; Pkn; meng", "protein_names_uniprotkb": "Serine/threonine-protein kinase meng-po; 2.7.11.1; SH3-binding kinase homolog; meng-po", "protein_names_refseq": "CG11221-PB; Meng-Po; meng-PB; meng-po, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11221)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;29473541", "class_list": "", "function": "Serine/threonine-protein kinase involved in memory formation. Together with the cAMP-dependent protein kinase A Pka-C1, promotes long-term memory (LTM) by regulating CrebB stability and activity. Involved in the maintenance of anesthesia-sensitive memory (ASM) which includes short-term memory (STM) and middle-term memory (MTM)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "5.6.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.8", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0007614 short-term memory;GO:0007616 long-term memory;GO:0072375 medium-term memory", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VM90-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VMA3-1", "uniprot_id": [ { "id": "CUP_DROME", "url": "https://www.uniprot.org/uniprot/Q9VMA3", "type": "external" } ], "mass": 125672.0, "length": 1117, "protein_name": "Protein cup", "gene_name": "cup", "organism": "Fruit fly", "refseq_name": "cup, isoform C", "refseq_ac": [ { "id": "NP_001285687", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285687", "type": "external" } ], "gene_names_uniprotkb": "cup; CG11181; CUP; Cup; DmCup; Dmel\\CG11181; Dmel_CG11181; fs(1)cup; fs(2)cup; i239", "gene_names_refseq": "CG11181; CUP; Cup; DmCup; Dmel\\CG11181; cup; fs(1)cup; fs(2)cup; i239", "protein_names_uniprotkb": "Protein cup; Oskar ribonucleoprotein complex 147 kDa subunit", "protein_names_refseq": "CG11181-PC; Cup; cup, isoform C; cup-PC", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11181)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "10662770;10731132;11060247;12537568;12537569;12537572;12537573;12537574;14685270;14691132;14723848;15465908;16110336;17178403;17277377;17569856;17569867;18327897;21081899;21937713;22164257;22454519;22832024;24335285;25589440;26109356;26109357;28875934;9118812", "class_list": "", "function": "Adapter protein that plays a central role in localization of transcripts in the oocyte and in young embryos (PubMed:9118812). Maintains RNA targets in a repressed state by promoting their deadenylation and protects deadenylated mRNAs from further degradation (PubMed:21937713). Binds to and recruits eIF-4E to the 3'-UTR of some mRNA targets which prevents interaction between eIF4E1 and eIF4G (PubMed:14685270, PubMed:15465908, PubMed:21081899). This may contribute to translational repression but does not appear to be necessary for it to occur (PubMed:21081899). Can promote translational repression independently of deadenylation and eIF4E1 binding (PubMed:21937713). Required for correct localization of eIF4E1 in the developing oocyte (PubMed:15465908). Required for translational repression of oskar (osk) mRNA (PubMed:14691132, PubMed:14723848). Also required for the translational repression of nanos (nos) mRNA (PubMed:21081899). Promotes the accumulation of the germ plasm components osk, vas and stau at the posterior pole of the oocyte and is required for germ cell development (PubMed:17277377, PubMed:22454519). Represses orb positive autoregulatory activity which prevents premature activation of orb and ensures its accumulation specifically in the developing oocyte (PubMed:22164257). In 0-1 hour embryos, forms a complex with me31B, cup, tral and pAbp which binds to various mRNAs including maternal mRNAs, and down-regulates their expression during the maternal-to-zygotic transition (PubMed:28875934)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O02432", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0008190 eukaryotic initiation factor 4E binding;GO:0045182 translation regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031594 neuromuscular junction;GO:0043195 terminal bouton", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007143 female meiotic nuclear division;GO:0017148 negative regulation of translation;GO:0045947 negative regulation of translational initiation;GO:0009953 dorsal/ventral pattern formation", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q9VMA3-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VMC8-1", "uniprot_id": [ { "id": "PHF5A_DROME", "url": "https://www.uniprot.org/uniprot/Q9VMC8", "type": "external" } ], "mass": 12522.0, "length": 111, "protein_name": "PHD finger-like domain-containing protein 5A", "gene_name": "Phf5a", "organism": "Fruit fly", "refseq_name": "PHD finger protein 5a", "refseq_ac": [ { "id": "NP_609038", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609038", "type": "external" } ], "gene_names_uniprotkb": "Phf5a; CG9548", "gene_names_refseq": "BcDNA:RH02789; CG9548; Dmel\\CG9548; PHF5A; Phf5a", "protein_names_uniprotkb": "PHD finger-like domain-containing protein 5A", "protein_names_refseq": "CG9548-PA; PHD finger protein 5a; Phf5a-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9548); (R-DME-72163); (R-DME-9770562); (R-DME-9943411)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B5RIJ7;Q8MQM8", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0071013 catalytic step 2 spliceosome;GO:0005686 U2 snRNP;GO:0071011 precatalytic spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VMC8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VMH0-1", "uniprot_id": [ { "id": "TECT_DROME", "url": "https://www.uniprot.org/uniprot/Q9VMH0", "type": "external" } ], "mass": 73933.0, "length": 657, "protein_name": "Tectonic", "gene_name": "tctn", "organism": "Fruit fly", "refseq_name": "tectonic", "refseq_ac": [ { "id": "NP_608998", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608998", "type": "external" } ], "gene_names_uniprotkb": "tctn; CG9227", "gene_names_refseq": "CG42731; CG9227; Dmel\\CG42731; Tectonic; tctn", "protein_names_uniprotkb": "Tectonic; dTectonic", "protein_names_refseq": "CG42731-PA; tctn-PA; tectonic", "tax_id": 7227, "disease": "orofaciodigital syndrome IV (Disease Ontology:DOID:0060374); Joubert syndrome 13 (Disease Ontology:DOID:0110982); Joubert syndrome 18 (Disease Ontology:DOID:0110987)", "pathway": " (dme:Dmel_CG42731)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;16357211;27646273", "class_list": "", "function": "Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia (PubMed:27646273). Has a role in ciliary structure and function (PubMed:27646273)., [UniProtKB, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 10, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q2MV53;Q8MSM0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0005814 centriole;GO:0036038 MKS complex;GO:0035869 ciliary transition zone", "go_biological_process": "GO:0060271 cilium assembly;GO:1905349 ciliary transition zone assembly;GO:0007288 sperm axoneme assembly;GO:1905350 Y-shaped link assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VMH0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VMM6-1", "uniprot_id": [ { "id": "OBSTE_DROME", "url": "https://www.uniprot.org/uniprot/Q9VMM6", "type": "external" } ], "mass": 27480.0, "length": 249, "protein_name": "Protein obstructor-E", "gene_name": "obst-E", "organism": "Fruit fly", "refseq_name": "obstructor-E, isoform A", "refseq_ac": [ { "id": "NP_608957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608957", "type": "external" } ], "gene_names_uniprotkb": "obst-E; CG11142", "gene_names_refseq": "CG11142; Dmel\\CG11142; Obst-E; obst-E", "protein_names_uniprotkb": "Protein obstructor-E", "protein_names_refseq": "CG11142-PA; obst-E-PA; obstructor-E, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11142)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;28076349", "class_list": "", "function": "Chitin-binding protein that is important for the longitudinal contraction and lateral expansion of the larval cuticle during its conversion into the oval-shaped puparium case. Essential for survival to the second instar larval stage. Confers the orientated contractility and expandability of the larval cuticle by regulating the arrangement of chitin and the formation of supracellular ridges on the cuticle of third instar larvae. Essential for determining pupal body shape; required for the orientated shape change of the cuticle during metamorphosis which involves changes in the morphology of the supracellular ridges., [UniProtKB, PubMed]; Mainly involved in larvae survival, possibly by maintaining the normal morphology of the larval hindgut during development., [UniProtKB, PubMed]; Mainly involved in regulating pupal shape., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8IGU3;Q8T0V6", "ec_number_list": [], "go_molecular_function": "GO:0008061 chitin binding;GO:0005214 structural constituent of chitin-based cuticle;GO:0008010 structural constituent of chitin-based larval cuticle;GO:0008011 structural constituent of pupal chitin-based cuticle", "go_cellular_component": "GO:0005576 extracellular region;GO:0062129 chitin-based extracellular matrix;GO:0030312 external encapsulating structure", "go_biological_process": "GO:0040003 chitin-based cuticle development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VMM6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0U1QT59-1", "uniprot_id": [ { "id": "TMC_DROME", "url": "https://www.uniprot.org/uniprot/A0A0U1QT59", "type": "external" } ], "mass": 227308.0, "length": 2036, "protein_name": "Transmembrane channel-like protein", "gene_name": "Tmc", "organism": "Fruit fly", "refseq_name": "transmembrane channel-like, isoform C", "refseq_ac": [ { "id": "NP_001303362", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303362", "type": "external" } ], "gene_names_uniprotkb": "Tmc; CG46121", "gene_names_refseq": "CG14177; CG3280; CG46121; DmTMC; Dmel\\CG46121; TMC; Tic; Tmc-L; Tmc; dTmc; tmc", "protein_names_uniprotkb": "Transmembrane channel-like protein", "protein_names_refseq": "CG46121-PC; Tmc-PC; transmembrane channel-like, isoform C; transmembrane channel-like", "tax_id": 7227, "disease": "autosomal recessive nonsyndromic deafness 7 (Disease Ontology:DOID:0110520); autosomal dominant nonsyndromic deafness 36 (Disease Ontology:DOID:0110563); sensorineural hearing loss (Disease Ontology:DOID:10003)", "pathway": " (dme:Dmel_CG46121)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10731132;12537572;27298354;27478019;30853433;31184585;32649914", "class_list": "", "function": "Probable ion channel (PubMed:27478019, PubMed:30853433, PubMed:31184585, PubMed:32649914). Component of mechanosensitive neurons that participates in proprioception, sensing food texture, and directing egg-laying site selection (oviposition) (PubMed:27298354, PubMed:27478019, PubMed:30853433, PubMed:31184585, PubMed:32649914). Component of multi-dendritic neurons of the labellum (md-L) where it is required for sensing the hardness and viscosity of their food, enabling them to behaviorally discriminate their preferred softness and smoothness from harder and stickier food options (PubMed:27478019). Required as part of oviposition site selection process to relay mechanosensory and chemosensory information on the hardness and sweetness of potential egg-laying substrates, thus ensuring females select the most optimal site for their eggs survival (PubMed:31184585, PubMed:32649914). Females determine the softest substrate for their eggs first by making a coarse evaluation of substrate hardness using mechanosensitive channels nan and Piezo in the leg tarsal bristles, followed by a much finer assessment using nan, iav and Tmc mechanosensitive channels on the labellum (PubMed:31184585, PubMed:32649914). This protein is required to sense subtle differences in substrate stiffness (between 0.25% and 0.3% agarose), likely acting in the md-L neurons (PubMed:32649914). Also required in neurons on the labellum, including the md-Ls, and possibly in the brain, to inhibit discrimination of egg-laying substrates of different hardness if the substrate contains sucrose (PubMed:32649914). During oviposition evaluation, activation of sweet neurons by sucrose enhances the activity of the Tmc neurons resulting in females losing their softness preference in favor of egg-laying sites that contain sucrose (PubMed:32649914). Acts in the larvae peripheral sensory neurons, to contribute to proprioception and sensory feedback for normal forward crawling behavior (PubMed:27298354, PubMed:30853433). Required for the normal activity of the proprioceptive sensory dendrites, ddaE which show preferential responses to forward locomotion, and ddaD which show preferential responses to backward locomotion (PubMed:30853433)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "M9NDN5", "ec_number_list": [], "go_molecular_function": "GO:0008381 mechanosensitive monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0001582 detection of chemical stimulus involved in sensory perception of sweet taste;GO:0050974 detection of mechanical stimulus involved in sensory perception;GO:0007635 chemosensory behavior;GO:0019230 proprioception;GO:0019232 perception of rate of movement", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A0U1QT59-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4KGY6-1", "uniprot_id": [ { "id": "NOVA_DROME", "url": "https://www.uniprot.org/uniprot/A0A0B4KGY6", "type": "external" } ], "mass": 81403.0, "length": 780, "protein_name": "RNA-binding protein Pasilla", "gene_name": "ps", "organism": "Fruit fly", "refseq_name": "pasilla, isoform C", "refseq_ac": [ { "id": "NP_731356", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_731356", "type": "external" } ], "gene_names_uniprotkb": "ps; CG42670; NOVA1; l(3)10615", "gene_names_refseq": "BcDNA:RE47781; CG16765; CG16776; CG16777; CG18509; CG42670; CG8144; Dmel\\CG42670; EP(3)3406; NOVA1; PS; Pasilla; cg8144; l(3)10615; ps", "protein_names_uniprotkb": "RNA-binding protein Pasilla", "protein_names_refseq": "CG42670-PC; lethal (3) 10615; pasilla, isoform C; pasilla; ps-PC", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG42670)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;11784037;12537569;12537572;28525754", "class_list": "", "function": "Functions to regulate alternative splicing in neurons by binding pre-mRNA in a sequence-specific manner to activate exon inclusion (By similarity). Plays a role in long-term memory formation by processing the unspliced Orb2-isoform A (Orb2A) mRNA and thereby controlling Orb2A protein abundance (PubMed:28525754)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4JCX5;A0A0B4KFY5;A0A0B4LGY5;A0A0B4LI06;Q0KI94;Q0KI96;Q8INP0;Q8T4D1;Q9GNC8;Q9GQN3;Q9GQN4;Q9VHD4;Q9VHD6", "ec_number_list": [], "go_molecular_function": "GO:0097157 pre-mRNA intronic binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0033120 positive regulation of RNA splicing;GO:0000398 mRNA splicing, via spliceosome;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A0B4KGY6-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VS48-1", "uniprot_id": [ { "id": "SLX4_DROME", "url": "https://www.uniprot.org/uniprot/Q9VS48", "type": "external" } ], "mass": 128216.0, "length": 1145, "protein_name": "Structure-specific endonuclease subunit SLX4", "gene_name": "mus312", "organism": "Fruit fly", "refseq_name": "mutagen-sensitive 312, isoform A", "refseq_ac": [ { "id": "NP_648104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648104", "type": "external" } ], "gene_names_uniprotkb": "mus312; CG8601; Dmel\\CG8601; Dmel_CG8601; MUS312; Mus312; SLX4; mus(3)312", "gene_names_refseq": "CG8601; Dmel\\CG8601; MUS312; Mus312; mus(3)312; mus312", "protein_names_uniprotkb": "Structure-specific endonuclease subunit SLX4; Mutagen-sensitive protein 312", "protein_names_refseq": "CG8601-PA; mus312-PA; mutagen-sensitive 312, isoform A", "tax_id": 7227, "disease": "Fanconi-like syndrome (Disease Ontology:DOID:0090066); Fanconi anemia complementation group P (Disease Ontology:DOID:0111092)", "pathway": " (dme:Dmel_CG8601)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12504024;12537568;12537572;12537573;12537574;16110336;17569856;17569867;19595722;19596236;25589440;26109356;26109357", "class_list": "", "function": "Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage (By similarity). Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA (By similarity). Interacts with the structure-specific MEI-9-ERCC1 endonuclease to generate meiotic crossovers., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0032991 protein-containing complex;GO:0033557 Slx1-Slx4 complex", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0006281 DNA repair;GO:0006260 DNA replication;GO:0045132 meiotic chromosome segregation;GO:0007131 reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VS48-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W0Y8-1", "uniprot_id": [ { "id": "SCN60_DROME", "url": "https://www.uniprot.org/uniprot/Q9W0Y8", "type": "external" } ], "mass": 321257.0, "length": 2844, "protein_name": "Sodium channel protein 60E", "gene_name": "NaCP60E", "organism": "Fruit fly", "refseq_name": "Na channel protein 60E, isoform H", "refseq_ac": [ { "id": "NP_001189007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001189007", "type": "external" } ], "gene_names_uniprotkb": "NaCP60E; CG18506; CG34405; CG9071; CT24831; DIC60; DSC1; DSCI; DSC; Dmel\\CG34405; Dmel_CG34405; Na-CP; dsc1; dsc; smi60E", "gene_names_refseq": "CG18506; CG34405; CG9071; CT24831; DIC60; DSC1; DSCI; DSC; Dmel\\CG34405; Na-CP; NaCP60E; dsc1; dsc; smi60E", "protein_names_uniprotkb": "Sodium channel protein 60E; DmNav2; Drosophila ion channel 60; Drosophila sodium channel 1; Protein smell-impaired 60E; Sodium channel 2", "protein_names_refseq": "CG34405-PH; Na channel protein 60E, isoform H; Na-channel-protein; NaCP60E-PH; put. sodium channel gene; smell impaired 60E; sodium channel 1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG34405)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;12196396;12537568;12537569;12537572;12537573;12537574;12907802;16110336;17569856;17569867;2444928;25589440;26109356;26109357;8083728", "class_list": "", "function": "Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Plays a role in processing of olfactory information during the olfactory avoidance response., [UniProtKB, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 6, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4KF50;A9NIV8;Q27930;Q7JN09;Q7JN86;Q7JN87;Q7JN88;Q7JN89;Q7K324;Q8MMC7", "ec_number_list": [], "go_molecular_function": "GO:0005248 voltage-gated sodium channel activity;GO:0022843 voltage-gated monoatomic cation channel activity;GO:0005261 monoatomic cation channel activity;GO:0005272 sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001518 voltage-gated sodium channel complex;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0042048 olfactory behavior;GO:0019228 neuronal action potential;GO:0086010 membrane depolarization during action potential;GO:0007608 sensory perception of smell;GO:0035725 sodium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9W0Y8-1", "record_type": "protein", "filter_code": "0000000.0000101.001000.000000100000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W252-1", "uniprot_id": [ { "id": "RAD50_DROME", "url": "https://www.uniprot.org/uniprot/Q9W252", "type": "external" } ], "mass": 152160.0, "length": 1318, "protein_name": "DNA repair protein RAD50", "gene_name": "rad50", "organism": "Fruit fly", "refseq_name": "rad50, isoform D", "refseq_ac": [ { "id": "NP_726199", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_726199", "type": "external" } ], "gene_names_uniprotkb": "rad50; 6339; CG6339; Dmel\\CG6339; Dmel_CG6339; Dmrad50; RAD50; Rad-50; Rad50; dRad50", "gene_names_refseq": "6339; CG6339; Dmel\\CG6339; Dmrad50; RAD50; Rad-50; Rad50; dRad50; rad50", "protein_names_uniprotkb": "DNA repair protein RAD50; 3.6.-.-", "protein_names_refseq": "CG6339-PD; rad50, isoform D; rad50-PD", "tax_id": 7227, "disease": "breast cancer (Disease Ontology:DOID:1612); transitional cell carcinoma (Disease Ontology:DOID:2671); invasive ductal carcinoma (Disease Ontology:DOID:3008); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (dme:Dmel_CG6339); (R-DME-2559586); (R-DME-5685939); (R-DME-5693548); (R-DME-5693565); (R-DME-5693607)", "pathway_count": 6, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15135728;15296753;16110336;17569856;17569867;18984573;25589440;26109356;26109357", "class_list": "", "function": "Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:15135728, PubMed:15296753). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (By similarity). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (By similarity). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (By similarity). Within the complex, RAD50 is both required to bind DNA ends and hold them in close proximity and regulate the activity of MRE11 (By similarity). RAD50 provides an ATP-dependent control of MRE11 by positioning DNA ends into the MRE11 active site: ATP-binding induces a large structural change from an open form with accessible MRE11 nuclease sites into a closed form (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B6UXS6;B6UXT1;B6UXT2;B6UXT3;B6UXT4;B6UXT5;B6UXT6;B6UXT7;B6UXT8;B6UXT9;B6UXU1;B6UXU2;B6UXU3;B6UXU4;B6UXU5;B6UXU6;B6UXU7;B6UXU8;B6UXU9;B6UXV0;B6UXV1;B6UXV2;Q86NZ9;Q960E0", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "3.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.-.-.-", "type": "external" }, { "id": "5.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0003690 double-stranded DNA binding;GO:0003691 double-stranded telomeric DNA binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0000793 condensed chromosome;GO:0000781 chromosome, telomeric region;GO:0030870 Mre11 complex", "go_biological_process": "GO:0006281 DNA repair;GO:0000723 telomere maintenance;GO:0006302 double-strand break repair;GO:0008104 intracellular protein localization;GO:0000729 DNA double-strand break processing", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9W252-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W123-1", "uniprot_id": [ { "id": "POF_DROME", "url": "https://www.uniprot.org/uniprot/Q9W123", "type": "external" } ], "mass": 55103.0, "length": 495, "protein_name": "Protein painting of fourth", "gene_name": "Pof", "organism": "Fruit fly", "refseq_name": "painting of fourth, isoform C", "refseq_ac": [ { "id": "NP_001246498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246498", "type": "external" } ], "gene_names_uniprotkb": "Pof; CG3691; Dmel\\CG3691; Dmel_CG3691; POF; cg3691; pof", "gene_names_refseq": "CG3691; Dmel\\CG3691; POF; Pof; cg3691; pof", "protein_names_uniprotkb": "Protein painting of fourth; Zeste-interacting protein 16; Zip16", "protein_names_refseq": "CG3691-PC; Pof-PC; painting of fourth chromosome; painting of fourth, isoform C; painting on the fourth; painting-of-fourth", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3691)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;11353870;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Probable RNA-binding protein that specifically binds to the fourth chromosome and may bind an RNA that spreads the fourth chromosome. May be a reminiscence of X chromosome dosage compensation of ancestral Drosophila species in which the X and the fourth chromosomes are one single chromosome., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0E8W2", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005694 chromosome;GO:1990904 ribonucleoprotein complex;GO:0030849 autosome", "go_biological_process": "GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9W123-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VNE9-1", "uniprot_id": [ { "id": "RL13A_DROME", "url": "https://www.uniprot.org/uniprot/Q9VNE9", "type": "external" } ], "mass": 23647.0, "length": 205, "protein_name": "Large ribosomal subunit protein uL13", "gene_name": "RpL13A", "organism": "Fruit fly", "refseq_name": "ribosomal protein L13A, isoform B", "refseq_ac": [ { "id": "NP_649560", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649560", "type": "external" } ], "gene_names_uniprotkb": "RpL13A; CG1475; Dmel\\CG1475; Dmel_CG1475; L13A; L13a2; L13; M(3)83B; RPL13A; Rp L13A; RpL13a; RpL13; Rpl13a; anon-EST:Posey125; anon-EST:fe1A5; bs25f04.y1; cg1475; chr3R:1451210..1451407", "gene_names_refseq": "CG1475; Dmel\\CG1475; L13A; L13a2; L13; M(3)83B; RPL13A; Rp L13A; RpL13A; RpL13a; RpL13; Rpl13a; anon-EST:Posey125; anon-EST:fe1A5; bs25f04.y1; cg1475; chr3R:1451210..1451407", "protein_names_uniprotkb": "Large ribosomal subunit protein uL13; 60S ribosomal protein L13a", "protein_names_refseq": "60S ribosomal protein L13A; CG1475-PB; RpL13A-PB; anon-fast-evolving-1A5; ribosomal protein L13A, isoform B; ribosomal protein L13a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1475); (R-DME-156827); (R-DME-1799339); (R-DME-72689); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954709); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 10, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;23636399;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VNF0", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005840 ribosome;GO:0022626 cytosolic ribosome;GO:0022625 cytosolic large ribosomal subunit;GO:0015934 large ribosomal subunit", "go_biological_process": "GO:0017148 negative regulation of translation;GO:0002181 cytoplasmic translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VNE9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W2E1-1", "uniprot_id": [ { "id": "STUM_DROME", "url": "https://www.uniprot.org/uniprot/Q9W2E1", "type": "external" } ], "mass": 203163.0, "length": 1870, "protein_name": "Protein stum", "gene_name": "stum", "organism": "Fruit fly", "refseq_name": "stumble, isoform D", "refseq_ac": [ { "id": "NP_001261125", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261125", "type": "external" } ], "gene_names_uniprotkb": "stum; CG15677; CG15679; CG30263; CT35864; Dmel\\CG30263; Dmel_CG30263; mdcds_15969", "gene_names_refseq": "CG15677; CG15679; CG30263; CT35864; Dmel\\CG30263; mdcds_15969; stum", "protein_names_uniprotkb": "Protein stum", "protein_names_refseq": "CG30263-PD; stum-PD; stumble, isoform D", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG30263)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;24626929;25589440;26109356;26109357", "class_list": "", "function": "Required for locomotion and mechanical sensing in proprioceptive neurons by transducing dendrite stretching into cellular responses. Required for transduction of mechanical stimuli in a specific subpopulation of proprioceptive neurons that sense joint angles. Probably does not constitute the mechanically activated channel and may rather serve as an accessory module required for the proper localization or function of the transduction channels., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q7YU83", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0030425 dendrite;GO:0071683 sensory dendrite", "go_biological_process": "GO:0050954 sensory perception of mechanical stimulus;GO:0019230 proprioception;GO:0042330 taxis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9W2E1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W1L5-1", "uniprot_id": [ { "id": "PAL2_DROME", "url": "https://www.uniprot.org/uniprot/Q9W1L5", "type": "external" } ], "mass": 44712.0, "length": 406, "protein_name": "Peptidyl-alpha-hydroxyglycine alpha-amidating lyase 2", "gene_name": "Pal2", "organism": "Fruit fly", "refseq_name": "Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase 2, isoform E", "refseq_ac": [ { "id": "NP_001286776", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286776", "type": "external" } ], "gene_names_uniprotkb": "Pal2; CG5472; Dmel\\CG5472; Dmel_CG5472; PAL2; PAL; Pal; anon-WO0149856.5; dPAL2", "gene_names_refseq": "CG5472; Dmel\\CG5472; PAL2; PAL; Pal2; Pal; anon-WO0149856.5; dPAL2", "protein_names_uniprotkb": "Peptidyl-alpha-hydroxyglycine alpha-amidating lyase 2; 4.3.2.5; Peptidylamidoglycolate lyase 2; dPAL2", "protein_names_refseq": "CG5472-PE; Pal2-PE; Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase 2, isoform E; Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase", "tax_id": 7227, "disease": "hypothyroidism (Disease Ontology:DOID:1459); prostate adenocarcinoma (Disease Ontology:DOID:2526)", "pathway": " (dme:Dmel_CG5472)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15198673;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Peptidyl-alpha-hydroxylglycine alpha-amidating lyase that catalyzes an essential reaction in C-terminal alpha-amidation of peptides. Mediates the dismutation of the unstable peptidyl(2-hydroxyglycine) intermediate to glyoxylate and the corresponding desglycine peptide amide. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4UZT8;Q7KVI0;Q9GPF3", "ec_number_list": [ { "id": "4.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.2.5", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004598 peptidylamidoglycolate lyase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9W1L5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W1K0-1", "uniprot_id": [ { "id": "TM14_DROME", "url": "https://www.uniprot.org/uniprot/Q9W1K0", "type": "external" } ], "mass": 11582.0, "length": 112, "protein_name": "Transmembrane protein 14 homolog", "gene_name": "Dmel\\CG5532", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001286781", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286781", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG5532; CG5532; Dmel_CG5532", "gene_names_refseq": "CG5532; Dmel\\CG5532", "protein_names_uniprotkb": "Transmembrane protein 14 homolog", "protein_names_refseq": "CG5532-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5532)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0016020 membrane", "go_biological_process": "GO:0006783 heme biosynthetic process;GO:0006784 heme A biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9W1K0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W1K5-1", "uniprot_id": [ { "id": "SESN_DROME", "url": "https://www.uniprot.org/uniprot/Q9W1K5", "type": "external" } ], "mass": 55853.0, "length": 497, "protein_name": "Sestrin homolog", "gene_name": "Sesn", "organism": "Fruit fly", "refseq_name": "sestrin, isoform B", "refseq_ac": [ { "id": "NP_001097437", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097437", "type": "external" } ], "gene_names_uniprotkb": "Sesn; BEST:GH20113; BcDNA:GH20113; CG11299; Dmel\\CG11299; Dmel_CG11299; dSesn; sesn", "gene_names_refseq": "BEST:GH20113; BcDNA:GH20113; CG11299; Dmel\\CG11299; Sesn; dSesn; sesn", "protein_names_uniprotkb": "Sestrin homolog; dSesn", "protein_names_refseq": "CG11299-PB; Sesn-PB; sestrin, isoform B; sestrin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11299); (R-DME-5628897); (R-DME-9755511)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;20203043;25589440;26109356;26109357;29123071;38514639", "class_list": "", "function": "Functions as a negative feedback regulator of mTOR function., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A8DYN7;Q9I7V1", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0016684 oxidoreductase activity, acting on peroxide as acceptor;GO:0004601 peroxidase activity;GO:0070728 L-leucine binding;GO:0140785 amino acid sensor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0030308 negative regulation of cell growth;GO:0016239 positive regulation of macroautophagy;GO:1904262 negative regulation of TORC1 signaling;GO:1901031 regulation of response to reactive oxygen species;GO:1990253 cellular response to leucine starvation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9W1K5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W145-1", "uniprot_id": [ { "id": "STRT1_DROME", "url": "https://www.uniprot.org/uniprot/Q9W145", "type": "external" } ], "mass": 65823.0, "length": 583, "protein_name": "Steroidogenic acute regulatory protein-like", "gene_name": "Start1", "organism": "Fruit fly", "refseq_name": "Start1, isoform C", "refseq_ac": [ { "id": "NP_001246495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246495", "type": "external" } ], "gene_names_uniprotkb": "Start1; CG3522; Dmel\\CG3522; Dmel_CG3522; StART1; Start; start1", "gene_names_refseq": "CG3522; Dmel\\CG3522; StART1; Start1; Start; start1", "protein_names_uniprotkb": "Steroidogenic acute regulatory protein-like", "protein_names_refseq": "CG3522-PC; Start1, isoform C; Start1-PC", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3522)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;14745013;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "May bind to and transport cholesterol and may play a role in ecdysteroid biosynthesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MZH4", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0120020 cholesterol transfer activity", "go_cellular_component": "GO:0031902 late endosome membrane;GO:0140284 endoplasmic reticulum-endosome membrane contact site", "go_biological_process": "GO:0006694 steroid biosynthetic process;GO:0030301 cholesterol transport;GO:0099044 vesicle tethering to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9W145-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VU58-1", "uniprot_id": [ { "id": "NPLP2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VU58", "type": "external" } ], "mass": 9412.0, "length": 86, "protein_name": "Neuropeptide-like 2", "gene_name": "Nplp2", "organism": "Fruit fly", "refseq_name": "Neuropeptide-like precursor 2, isoform B", "refseq_ac": [ { "id": "NP_001287059", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287059", "type": "external" } ], "gene_names_uniprotkb": "Nplp2; BcDNA:RH08410; CG11051; DIM 7; DIM7; Dmel\\CG11051; Dmel_CG11051; IM7; NEF; NPLP 2; NPLP2; nplp2", "gene_names_refseq": "BcDNA:RH08410; CG11051; DIM 7; DIM7; Dmel\\CG11051; IM7; NEF; NPLP 2; NPLP2; Nplp2; nplp2", "protein_names_uniprotkb": "Neuropeptide-like 2; NEF peptide", "protein_names_refseq": "CG11051-PB; NEF peptide; Neuropeptide-like precursor 2, isoform B; Nplp2-PB; immune induced molecule 7; neuropeptide-like precursor 2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11051)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10731132;12171930;12537568;12537569;12537572;12537573;12537574;14690519;16110336;16510152;17569856;17569867;25589440;26109356;26109357;33925313;40245499", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0006959 humoral immune response", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9VU58-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W4V8-1", "uniprot_id": [ { "id": "TI50C_DROME", "url": "https://www.uniprot.org/uniprot/Q9W4V8", "type": "external" } ], "mass": 49671.0, "length": 428, "protein_name": "Mitochondrial import inner membrane translocase subunit TIM50-C", "gene_name": "ttm50", "organism": "Fruit fly", "refseq_name": "tiny tim 50, isoform B", "refseq_ac": [ { "id": "NP_001303557", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303557", "type": "external" } ], "gene_names_uniprotkb": "ttm50; 17944223; CG2713; Dmel\\CG2713; Dmel_CG2713; EG:95B7.3; Gp99; Ttm50; i238; i90", "gene_names_refseq": "17944223; CG2713; Dmel\\CG2713; EG:95B7.3; Gp99; Ttm50; i238; i90; ttm50", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit TIM50-C; Tiny tim 50", "protein_names_refseq": "CG2713-PB; Gp99; tiny tim 50, isoform B; ttm50-PB", "tax_id": 7227, "disease": "3-methylglutaconic aciduria type 9 (Disease Ontology:DOID:0070002)", "pathway": " (dme:Dmel_CG2713)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;10731137;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O76907;Q8SZT0", "ec_number_list": [], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity;GO:0140608 cysteine-type endopeptidase activator activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005744 TIM23 mitochondrial import inner membrane translocase complex", "go_biological_process": "GO:0006470 protein dephosphorylation;GO:0007005 mitochondrion organization;GO:0070972 protein localization to endoplasmic reticulum;GO:0034067 protein localization to Golgi apparatus;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9W4V8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Y0Y6-1", "uniprot_id": [ { "id": "NRBP_DROME", "url": "https://www.uniprot.org/uniprot/Q9Y0Y6", "type": "external" } ], "mass": 70508.0, "length": 637, "protein_name": "Nuclear receptor-binding protein homolog", "gene_name": "Madm", "organism": "Fruit fly", "refseq_name": "MLF1-adaptor molecule, isoform B", "refseq_ac": [ { "id": "NP_001303420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303420", "type": "external" } ], "gene_names_uniprotkb": "Madm; BcDNA:LD28657; CG1098; Dmel\\CG1098; Dmel_CG1098; MADM; MadM; anon-WO0118547.406; dMADM; lincRNA.S6031", "gene_names_refseq": "BcDNA:LD28657; CG1098; Dmel\\CG1098; MADM; MadM; Madm; anon-WO0118547.406; dMADM; lincRNA.S6031", "protein_names_uniprotkb": "Nuclear receptor-binding protein homolog; MLF1-adaptor molecule", "protein_names_refseq": "CG1098-PB; MLF1-adaptor molecule, isoform B; Madm-PB; Mif1 adaptor molecule", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1098)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;10731137;12176995;12537568;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005938 cell cortex;GO:0012505 endomembrane system", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0042127 regulation of cell population proliferation;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0009306 protein secretion;GO:0008361 regulation of cell size", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9Y0Y6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VSR3-1", "uniprot_id": [ { "id": "ORB2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VSR3", "type": "external" } ], "mass": 74504.0, "length": 704, "protein_name": "Translational regulator orb2", "gene_name": "orb2", "organism": "Fruit fly", "refseq_name": "orb2, isoform D", "refseq_ac": [ { "id": "NP_001261608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261608", "type": "external" } ], "gene_names_uniprotkb": "orb2; CG43113; CG43782; CG5735; Dmel\\CG43782; Dmel_CG43782; Orb2A; Orb2B; Orb2; anon-WO0140519.222; cg5735", "gene_names_refseq": "CG43113; CG43782; CG5735; Dmel\\CG43782; Orb2A; Orb2B; Orb2; anon-WO0140519.222; cg5735; orb2", "protein_names_uniprotkb": "Translational regulator orb2", "protein_names_refseq": "CG43782-PD; cg43782 gene product from transcript cg43782-rh; orb2, isoform D; orb2-PD", "tax_id": 7227, "disease": "portal hypertension (Disease Ontology:DOID:10762); primary biliary cholangitis (Disease Ontology:DOID:12236); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (dme:Dmel_CG43782)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;17965711;18327897;20547833;21900268;22284910;23083740;23209437;24523662;24830287;25589440;26095367;26109356;26109357;26638074;26812143;28525754;28700922;29105522;29317541;32165583", "class_list": "", "function": "RNA-binding protein involved in translational regulation and required for long-term memory (PubMed:28525754, PubMed:29105522). Required in mushroom body gamma neurons for long-term memory in male courtship (PubMed:17965711, PubMed:23083740). Binds to mRNA 3'-UTRs (PubMed:20547833, PubMed:24830287, PubMed:26095367, PubMed:26638074, PubMed:32165583). In its monomeric form, acts as a translational repressor of genes involved in neuronal growth, synapse formation and protein turnover (PubMed:20547833, PubMed:26638074, PubMed:32165583). In its amyloid-like oligomeric form, acts as a translational activator (PubMed:26638074, PubMed:32165583). The monomeric form reduces poly(A) tail length and destabilizes mRNA while the oligomeric form protects and elongates the poly(A) tail and stabilizes mRNA (PubMed:26638074). Involved in asymmetric cell division in the central nervous system (PubMed:21900268). Plays a role in synapse formation and morphology at neuromuscular junctions by modulating the translation of the tumor suppressor brat (PubMed:29105522). Required for the progression of spermatogenesis through meiosis and for sperm differentiation (PubMed:23209437). During sperm differentiation, required to asymmetrically localize and activate the translation of protein kinase aPKC mRNAs which is necessary for spermatid cyst polarization (PubMed:24830287). Also required during spermatid cyst polarization for localization and translation of its own mRNA (PubMed:24830287)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Required for initial memory acquisition (PubMed:26095367, PubMed:28525754). Following subsequent late dopaminergic pathway activation, recruits isoform B into a complex to activate translation of CaMKII which is required for long-term memory consolidation (PubMed:26095367)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95T31;Q9VSR2", "ec_number_list": [], "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0008135 translation factor activity, RNA binding;GO:0008494 translation activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005938 cell cortex;GO:0030424 axon", "go_biological_process": "GO:0008049 male courtship behavior;GO:0007283 spermatogenesis;GO:0050821 protein stabilization;GO:0017148 negative regulation of translation;GO:0045727 positive regulation of translation", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q9VSR3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W2M2-1", "uniprot_id": [ { "id": "TREA_DROME", "url": "https://www.uniprot.org/uniprot/Q9W2M2", "type": "external" } ], "mass": 67689.0, "length": 596, "protein_name": "Trehalase", "gene_name": "Treh", "organism": "Fruit fly", "refseq_name": "trehalase, isoform G", "refseq_ac": [ { "id": "NP_001261115", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261115", "type": "external" } ], "gene_names_uniprotkb": "Treh; 87D3T; CG9364; DmTre; Dmel\\CG9364; Dmel_CG9364; ESTS:87D3T; FBgn0003748; TREH; TRE; Tre; anon-EST:Posey159; anon-sts38; treh", "gene_names_refseq": "87D3T; CG9364; DmTre; Dmel\\CG9364; ESTS:87D3T; FBgn0003748; TREH; TRE; Treh; Tre; anon-EST:Posey159; anon-sts38; treh", "protein_names_uniprotkb": "Trehalase; 3.2.1.28; Alpha,alpha-trehalase; Alpha,alpha-trehalose glucohydrolase", "protein_names_refseq": "CG9364-PG; Treh-PG; trehalase, isoform G; trehalase", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9364)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;17893096;25589440;26109356;26109357;26235423", "class_list": "glycogene;glycosylhydrolase", "function": "Enzyme that cleaves trehalose to produce 2 glucose molecules that can be used by the glycolytic pathway (Probable). Glycolysis is essential in glial cells but not in neurons; neurons rely on the citric acid cycle for their energy needs, and on lactate and alanine secreted into the hemolymph by glial cells to fuel it (PubMed:26235423)., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q0E903;Q0E904;Q7YWL2;Q961P0;Q9W2M1;Q9W2M3", "ec_number_list": [ { "id": "3.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.28", "type": "external" } ], "go_molecular_function": "GO:0004555 alpha,alpha-trehalase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol", "go_biological_process": "GO:0005993 trehalose catabolic process;GO:0005991 trehalose metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9W2M2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.1000000010000.101.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W429-1", "uniprot_id": [ { "id": "S35B4_DROME", "url": "https://www.uniprot.org/uniprot/Q9W429", "type": "external" } ], "mass": 39494.0, "length": 352, "protein_name": "Endoplasmic reticulum GDP-fucose transporter", "gene_name": "Efr", "organism": "Fruit fly", "refseq_name": "ER GDP-fucose transporter, isoform A", "refseq_ac": [ { "id": "NP_572299", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572299", "type": "external" } ], "gene_names_uniprotkb": "Efr; CG3774; Dmel\\CG3774; Dmel_CG3774; efr", "gene_names_refseq": "CG3774; Dmel\\CG3774; Efr; efr", "protein_names_uniprotkb": "Endoplasmic reticulum GDP-fucose transporter; Solute carrier family 35 member B4 homolog; UDP-xylose and UDP-N-acetylglucosamine transporter", "protein_names_refseq": "CG3774-PA; ER GDP-fucose transporter, isoform A; ER GFP-fucose transporter; Efr-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3774); (R-DME-727802)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;19948734;25589440;26109356;26109357", "class_list": "", "function": "Sugar transporter that specifically mediates the transport of UDP-N-acetylglucosamine (UDP-GlcNAc), GDP-fucose and UDP-xylose. Functions redundantly with Gfr in the O-fucosylation of Notch, positively regulating Notch signaling. Involved in the biosynthesis of heparan sulfate-glycosaminoglycan (HS-GAG) and in Dpp signaling in the wing imaginal disk., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BIK7", "ec_number_list": [], "go_molecular_function": "GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity;GO:0005464 UDP-xylose transmembrane transporter activity;GO:0005457 GDP-fucose transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0015783 GDP-fucose transmembrane transport;GO:0015790 UDP-xylose transmembrane transport;GO:1990569 UDP-N-acetylglucosamine transmembrane transport;GO:0036084 GDP-fucose import into endoplasmic reticulum lumen;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9W429-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VZ23-1", "uniprot_id": [ { "id": "RAN_DROME", "url": "https://www.uniprot.org/uniprot/Q9VZ23", "type": "external" } ], "mass": 24708.0, "length": 216, "protein_name": "GTP-binding nuclear protein Ran", "gene_name": "Ran", "organism": "Fruit fly", "refseq_name": "Ran, isoform C", "refseq_ac": [ { "id": "NP_001285111", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285111", "type": "external" } ], "gene_names_uniprotkb": "Ran; AAF30287; CG1404; Dmel\\CG1404; Dmel_CG1404; Q9VZ23; RAN; Ran10A; RanGTP; dran; l(1)G0075; ran10A; ran", "gene_names_refseq": "AAF30287; CG1404; Dmel\\CG1404; Q9VZ23; RAN; RanGTP; Ran; dran; l(1)G0075; ran10A; ran", "protein_names_uniprotkb": "GTP-binding nuclear protein Ran; Ras-related nuclear protein", "protein_names_refseq": "CG1404-PC; Ran GTPase; Ran, isoform C; Ran-PC; ran", "tax_id": 7227, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dme:Dmel_CG1404); (R-DME-1655829); (R-DME-5578749); (R-DME-9615933)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "10731132;12121620;12537568;12537569;12537572;12537573;12537574;12653959;15952742;16110336;17569856;17569867;25589440;26109356;26109357;31626769", "class_list": "", "function": "GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle., [UniProtKB, UniProtKB]; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis (By similarity). GTP-bound Ran modulates both spindle and nuclear envelope assembly, supporting a role during mitosis (PubMed:12121620). During oogenesis, modulates formation of Nup358-containing granules and biogenesis of the nuclear pore complex probably by mediating the transport of their components along microtubules (PubMed:31626769)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9NH14;Q9NHN9", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005938 cell cortex;GO:1990498 mitotic spindle microtubule", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0051301 cell division;GO:0007346 regulation of mitotic cell cycle;GO:0032880 regulation of protein localization;GO:0000054 ribosomal subunit export from nucleus", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9VZ23-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W4D2-1", "uniprot_id": [ { "id": "RNP4F_DROME", "url": "https://www.uniprot.org/uniprot/Q9W4D2", "type": "external" } ], "mass": 106740.0, "length": 941, "protein_name": "RNA-binding protein 4F", "gene_name": "Rnp4F", "organism": "Fruit fly", "refseq_name": "RNA-binding protein 4F, isoform F", "refseq_ac": [ { "id": "NP_001096883", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096883", "type": "external" } ], "gene_names_uniprotkb": "Rnp4F; 4F-rnp; 4f-rnp; CG3312; Dmel\\CG3312; Dmel_CG3312; RNP-4F; Rnp-4F; Rnp4f; rnp-4f", "gene_names_refseq": "4F-rnp; 4f-rnp; CG3312; Dmel\\CG3312; RNP-4F; Rnp-4F; Rnp4F; Rnp4f; rnp-4f", "protein_names_uniprotkb": "RNA-binding protein 4F", "protein_names_refseq": "CG3312-PF; RNA-binding protein 4F, isoform F; Rnp4F-PF; splicing assembly factor rnp-4f", "tax_id": 7227, "disease": "spermatogenic failure (Disease Ontology:DOID:0111910)", "pathway": " (dme:Dmel_CG3312)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;12756328;16110336;16497447;17569856;17569867;18327897;25589440;26109356;26109357;9434193", "class_list": "", "function": "May be involved in gene regulation during development. Binds RNA., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V3Z4;O18351;O18352;Q2VC69;Q2VC70;Q2VC71;Q2VC72;Q2VC73;Q2XP46", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0061574 ASAP complex", "go_biological_process": "GO:0007417 central nervous system development;GO:0000398 mRNA splicing, via spliceosome;GO:0006396 RNA processing", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9W4D2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W0W6-1", "uniprot_id": [ { "id": "NPLP1_DROME", "url": "https://www.uniprot.org/uniprot/Q9W0W6", "type": "external" } ], "mass": 34198.0, "length": 309, "protein_name": "Neuropeptide-like 1", "gene_name": "Nplp1", "organism": "Fruit fly", "refseq_name": "Neuropeptide-like precursor 1, isoform A", "refseq_ac": [ { "id": "NP_611993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611993", "type": "external" } ], "gene_names_uniprotkb": "Nplp1; APK; CG3441; Dmel\\CG3441; Dmel_CG3441; IPNamide; IPNa; MTY-amide; MTYamide; MTYa; NPLP-1; NPLP1; VQQ; nplp1", "gene_names_refseq": "APK; CG3441; Dmel\\CG3441; IPNamide; IPNa; MTY-amide; MTYamide; MTYa; NPLP-1; NPLP1; Nplp1; VQQ; nplp1", "protein_names_uniprotkb": "Neuropeptide-like 1", "protein_names_refseq": "APK peptide; CG3441-PA; IPNamide peptide; IPNamide; MTYamide peptide; Neuropeptide-like precursor 1, isoform A; Nplp1-PA; neuropeptide like precursor 1; neuropeptide like precursor protein 1; neuropeptide-like precursor 1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3441)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;12171930;12537568;12537569;12537572;12537573;12537574;14690519;16110336;17569856;17569867;21893139;25589440;26109356;26109357;26440503", "class_list": "", "function": "Acts as a ligand for the receptor-type guanylate cyclase Gyc76C (PubMed:21893139). Stimulates Gyc76c-dependent cGMP production and modulates the IMD innate immune pathway in response to salt stress by inducing nuclear translocation of NF-kappa-B protein Rel which leads to increased expression of the antimicrobial peptide diptericin (PubMed:21893139). Does not appear to play a role in Gyc76C-mediated wing development (PubMed:26440503)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95T41", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0007168 receptor guanylyl cyclase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9W0W6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W1A4-1", "uniprot_id": [ { "id": "TAMO_DROME", "url": "https://www.uniprot.org/uniprot/Q9W1A4", "type": "external" } ], "mass": 87914.0, "length": 797, "protein_name": "Protein tamozhennic", "gene_name": "tamo", "organism": "Fruit fly", "refseq_name": "tamo, isoform C", "refseq_ac": [ { "id": "NP_001286827", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286827", "type": "external" } ], "gene_names_uniprotkb": "tamo; 60B; CG4057; Dmel\\CG4057; Dmel_CG4057", "gene_names_refseq": "60B; CG4057; Dmel\\CG4057; tamo", "protein_names_uniprotkb": "Protein tamozhennic", "protein_names_refseq": "CG4057-PC; tamo, isoform C; tamo-PC", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4057)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;12653959;16110336;17569856;17569867;25589440;26109356;26109357;40245499", "class_list": "", "function": "Has an essential role during oogenesis and embryogenesis, perhaps in modulating the levels of nuclear import of additional proteins. Modulates the nuclear import of dorsal (dl), Dif and male specific lethal 1 (msl-1). Negatively regulates nuclear import of dl and controls the accumulation of dl in the nucleus after immune challenge., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q0E8W9;Q8SZS5", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0015031 protein transport;GO:0042306 regulation of protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9W1A4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Y0H4-1", "uniprot_id": [ { "id": "SUDX_DROME", "url": "https://www.uniprot.org/uniprot/Q9Y0H4", "type": "external" } ], "mass": 107966.0, "length": 949, "protein_name": "E3 ubiquitin-protein ligase Su(dx)", "gene_name": "Su(dx)", "organism": "Fruit fly", "refseq_name": "suppressor of deltex, isoform F", "refseq_ac": [ { "id": "NP_001259898", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259898", "type": "external" } ], "gene_names_uniprotkb": "Su(dx); AIP4; CG4244; Dmel\\CG4244; Dmel_CG4244; ITCH; Itch; Su (Dx); Su(DX); Su(Dx); Su(deltex); anon-WO0073329.1; anon-WO0073329.2; anon-WO0073329.4; su(dx); sudx", "gene_names_refseq": "AIP4; CG4244; Dmel\\CG4244; ITCH; Itch; Su (Dx); Su(DX); Su(Dx); Su(deltex); Su(dx); anon-WO0073329.1; anon-WO0073329.2; anon-WO0073329.4; su(dx); sudx", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Su(dx); 2.3.2.26; HECT-type E3 ubiquitin transferase Su(dx); Protein suppressor of deltex", "protein_names_refseq": "CG4244-PF; Su(dx)-PF; suppressor of deltex, isoform F; suppressor of deltex; supressor of deltex", "tax_id": 7227, "disease": "Liddle syndrome (Disease Ontology:DOID:0050477)", "pathway": " (dme:Dmel_CG4244); (R-DME-1253288); (R-DME-2122948); (R-DME-8939236); (R-DME-8948751); (R-DME-9013406); (R-DME-9013420); (R-DME-983168)", "pathway_count": 8, "publication_count": 16, "publication_id_list": "10353900;10731132;12537568;12537569;12537572;12537573;12537574;12648496;15173166;15620650;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Notch/N signaling pathway, probably by promoting Notch ubiquitination, endocytosis and degradation. Involved in wing growth and leg joint formation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4UZZ3;Q0E8U5;Q8T0C8", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0005112 Notch binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005938 cell cortex", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0031623 receptor internalization;GO:0032880 regulation of protein localization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9Y0H4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VVE5-1", "uniprot_id": [ { "id": "MSIR6_DROME", "url": "https://www.uniprot.org/uniprot/Q9VVE5", "type": "external" } ], "mass": 40087.0, "length": 369, "protein_name": "RNA-binding protein Musashi homolog Rbp6", "gene_name": "Rbp6", "organism": "Fruit fly", "refseq_name": "RNA-binding protein 6, isoform B", "refseq_ac": [ { "id": "NP_001097631", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097631", "type": "external" } ], "gene_names_uniprotkb": "Rbp6; BcDNA:RE25373; CG14055; CG14056; CG32169; CG6573; Dmel\\CG32169; Dmel_CG32169; RRM6; rbp6; rrm6", "gene_names_refseq": "BcDNA:RE25373; CG14055; CG14056; CG32169; CG6573; Dmel\\CG32169; RRM6; Rbp6; rbp6; rrm6", "protein_names_uniprotkb": "RNA-binding protein Musashi homolog Rbp6", "protein_names_refseq": "CG32169-PB; RNA-binding protein 6, isoform B; Rbp6-PB", "tax_id": 7227, "disease": "autosomal dominant limb-girdle muscular dystrophy type 3 (Disease Ontology:DOID:0110306); brain ischemia (Disease Ontology:DOID:2316); brain infarction (Disease Ontology:DOID:3454)", "pathway": " (dme:Dmel_CG32169); (R-DME-9013418)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;33925313;8417324", "class_list": "", "function": "RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A8JNU7;A8JNU8;Q26276;Q8MQZ1", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003727 single-stranded RNA binding;GO:0008266 poly(U) RNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006417 regulation of translation;GO:0048864 stem cell development", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9VVE5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VVI3-1", "uniprot_id": [ { "id": "NEDD4_DROME", "url": "https://www.uniprot.org/uniprot/Q9VVI3", "type": "external" } ], "mass": 114875.0, "length": 1007, "protein_name": "E3 ubiquitin-protein ligase Nedd-4", "gene_name": "Nedd4", "organism": "Fruit fly", "refseq_name": "Nedd4, isoform J", "refseq_ac": [ { "id": "NP_648993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648993", "type": "external" } ], "gene_names_uniprotkb": "Nedd4; ACN62428.1; CG32184; CG42279; CG7555; DNedd4; Dmel\\CG42279; Dmel_CG42279; NEDD4; dNedd4-1; dNedd4; nedd4", "gene_names_refseq": "ACN62428.1; CG32184; CG42279; CG7555; DNedd4; Dmel\\CG42279; NEDD4; Nedd4; dNedd4-1; dNedd4; nedd4", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Nedd-4; 2.3.2.26; DNedd4; HECT-type E3 ubiquitin transferase NEDD4", "protein_names_refseq": "CG42279-PJ; DNedd4; Nedd4, isoform J; Nedd4-PJ", "tax_id": 7227, "disease": "periventricular nodular heterotopia (Disease Ontology:DOID:0050454); Liddle syndrome (Disease Ontology:DOID:0050477); stroke (Disease Ontology:DOID:0051061); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (dme:Dmel_CG42279); (R-DME-1253288); (R-DME-2173795); (R-DME-8948747); (R-DME-8948751); (R-DME-983168)", "pathway_count": 6, "publication_count": 17, "publication_id_list": "10731132;12165468;12537568;12537569;12537572;12537573;12537574;15620649;15657595;16110336;16531238;17084358;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Essential E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Notch signaling pathway by promoting N/Notch ubiquitination, endocytosis and degradation. During development suppresses activation of the Notch signaling pathway in imaginal disk cells (PubMed:17084358)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7KUR2;Q8IQR6;Q95R64;Q95TQ0;Q95ZF9", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0019871 sodium channel inhibitor activity;GO:0019904 protein domain specific binding;GO:0005112 Notch binding;GO:0017022 myosin binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0071212 subsynaptic reticulum", "go_biological_process": "GO:1905062 positive regulation of cardioblast proliferation;GO:0007219 Notch signaling pathway;GO:0007528 neuromuscular junction development;GO:0016199 axon midline choice point recognition;GO:0031623 receptor internalization", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9VVI3-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VXG1-1", "uniprot_id": [ { "id": "HANG_DROME", "url": "https://www.uniprot.org/uniprot/Q9VXG1", "type": "external" } ], "mass": 213792.0, "length": 1959, "protein_name": "Zinc finger protein hangover", "gene_name": "hang", "organism": "Fruit fly", "refseq_name": "hangover, isoform D", "refseq_ac": [ { "id": "NP_727979", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_727979", "type": "external" } ], "gene_names_uniprotkb": "hang; BcDNA:GM07804; BcDNA:LD22118; CG32575; CG4411; CG4416; Dmel\\CG32575; Dmel_CG32575; HANG; Hang; LD22118", "gene_names_refseq": "BcDNA:GM07804; BcDNA:LD22118; CG32575; CG4411; CG4416; Dmel\\CG32575; HANG; Hang; LD22118; hang", "protein_names_uniprotkb": "Zinc finger protein hangover", "protein_names_refseq": "CG32575-PD; hang-PD; hangover, isoform D", "tax_id": 7227, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (dme:Dmel_CG32575)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16094367;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Required for normal development of ethanol tolerance. Relies on two distinct molecular pathways: a cellular stress pathway defined by hang, and a parallel pathway requiring octopamine., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9VXG2", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006979 response to oxidative stress;GO:0045471 response to ethanol;GO:0048149 behavioral response to ethanol;GO:0009408 response to heat", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VXG1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VYN8-1", "uniprot_id": [ { "id": "TENA_DROME", "url": "https://www.uniprot.org/uniprot/Q9VYN8", "type": "external" } ], "mass": 327437.0, "length": 3004, "protein_name": "Teneurin-a", "gene_name": "Ten-a", "organism": "Fruit fly", "refseq_name": "tenascin accessory, isoform F", "refseq_ac": [ { "id": "NP_001138190", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138190", "type": "external" } ], "gene_names_uniprotkb": "Ten-a; 1.2; CG11270; CG12720; CG15733; CG18182; CG2578; CG2590; CG32659; CG42338; Dmel\\CG42338; Dmel_CG42338; DmtenA; Dmtena; Ten11A; Ten[a]; cbd; ten-a; tenA(AT)[[14]]; tenA; ten[a]", "gene_names_refseq": "1.2; CG11270; CG12720; CG15733; CG18182; CG2578; CG2590; CG32659; CG42338; Dmel\\CG42338; DmtenA; Dmtena; Ten-a; Ten11A; Ten[a]; cbd; ten-a; tenA(AT)[[14]]; tenA; ten[a]", "protein_names_uniprotkb": "Teneurin-a; Tenascin-like protein; Tena", "protein_names_refseq": "CG42338-PF; Ten-a-PF; Teneurin-a; central body defect; central-body-defect; tenascin accessory, isoform F; tenascin-like molecule accessory; teneurin", "tax_id": 7227, "disease": "essential tremor 5 (Disease Ontology:DOID:0111432); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (dme:Dmel_CG42338)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;12175511;12537568;12537572;12537573;12537574;16110336;17569856;17569867;22425994;22426000;25589440;26109356;26109357;7684246", "class_list": "", "function": "Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Acts as a homophilic and heterophilic synaptic cell adhesion molecule that drives synapse assembly. Promotes bi-directional trans-synaptic signaling with ten-m to organize neuromuscular synapses., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q24550", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0030424 axon;GO:0031012 extracellular matrix;GO:0031594 neuromuscular junction;GO:0043025 neuronal cell body", "go_biological_process": "GO:2000331 regulation of terminal button organization;GO:0048790 maintenance of presynaptic active zone structure;GO:0007155 cell adhesion;GO:0007274 neuromuscular synaptic transmission;GO:0050808 synapse organization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9VYN8-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VZW8-1", "uniprot_id": [ { "id": "OR63A_DROME", "url": "https://www.uniprot.org/uniprot/Q9VZW8", "type": "external" } ], "mass": 49611.0, "length": 420, "protein_name": "Odorant receptor 63a", "gene_name": "Or63a", "organism": "Fruit fly", "refseq_name": "odorant receptor 63a, isoform A", "refseq_ac": [ { "id": "NP_523895", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523895", "type": "external" } ], "gene_names_uniprotkb": "Or63a; 63B.1; 63a; CG9969; DOR28; Dmel\\CG9969; Dmel_CG9969; OR63a; Or63aA", "gene_names_refseq": "63B.1; 63a; CG9969; DOR28; Dmel\\CG9969; OR63a; Or63aA; Or63a", "protein_names_uniprotkb": "Odorant receptor 63a", "protein_names_refseq": "CG9969-PA; Or63a-PA; odorant receptor 63a, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9969)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;21857978;25589440;26109356;26109357", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to butyl acetate, isoamyl acetate, and hexanoic acid., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VZW8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VMU4-1", "uniprot_id": [ { "id": "RL37A_DROME", "url": "https://www.uniprot.org/uniprot/Q9VMU4", "type": "external" } ], "mass": 10311.0, "length": 92, "protein_name": "Large ribosomal subunit protein eL43", "gene_name": "RpL37A", "organism": "Fruit fly", "refseq_name": "ribosomal protein L37A, isoform C", "refseq_ac": [ { "id": "NP_001188691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001188691", "type": "external" } ], "gene_names_uniprotkb": "RpL37A; BcDNA:RE23595; BcDNA:RH41593; CG5827; DmL37a; Dmel\\CG5827; Dmel_CG5827; L37A; L43e; M(2)25C; M(2)S1; RpL37a; chr2L:5071724..5071820; l(2)25Cb", "gene_names_refseq": "BcDNA:RE23595; BcDNA:RH41593; CG5827; DmL37a; Dmel\\CG5827; L37A; L43e; M(2)25C; M(2)S1; RpL37A; RpL37a; chr2L:5071724..5071820; l(2)25Cb", "protein_names_uniprotkb": "Large ribosomal subunit protein eL43; 60S ribosomal protein L37a", "protein_names_refseq": "CG5827-PC; RpL37A-PC; minute (2) 25C; ribosomal protein L37A, isoform C; ribosomal protein L37a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5827)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;23636399;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V081", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022626 cytosolic ribosome;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VMU4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W534-1", "uniprot_id": [ { "id": "MOODY_DROME", "url": "https://www.uniprot.org/uniprot/Q9W534", "type": "external" } ], "mass": 71932.0, "length": 670, "protein_name": "G protein-coupled receptor moody", "gene_name": "moody", "organism": "Fruit fly", "refseq_name": "moody, isoform B", "refseq_ac": [ { "id": "NP_001188534", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001188534", "type": "external" } ], "gene_names_uniprotkb": "moody; 1631; CG4322; Dmel\\CG4322; Dmel_CG4322; EG:22E5.11; EP1631; Moody", "gene_names_refseq": "1631; CG4322; Dmel\\CG4322; EG:22E5.11; EP1631; Moody; moody", "protein_names_uniprotkb": "G protein-coupled receptor moody", "protein_names_refseq": "CG4322-PB; moody receptor; moody, isoform B; moody-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4322)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;10731137;12537568;12537569;12537572;12537573;12537574;16110336;16213218;16213219;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Isoform A and isoform B are required in glia to regulate the acute sensitivity to cocaine and to continuously maintain the proper blood-brain barrier (BBB) function. A moody-mediated signaling pathway functions in glia to regulate nervous system insulation and drug-related behaviors. Galphai and Galphao, and the regulator of G protein signaling, loco, are required in the surface glia to achieve effective insulation. The components function by regulating the cortical actin and thereby stabilizing the extended morphology of the surface glia, which in turn is necessary for the formation of septate junctions of sufficient length to achieve proper sealing of the nerve cord., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O77270;Q8MRD0", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005919 pleated septate junction", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0035095 behavioral response to nicotine;GO:0048149 behavioral response to ethanol;GO:0048148 behavioral response to cocaine;GO:0030866 cortical actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9W534-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VX10-1", "uniprot_id": [ { "id": "SRX_DROME", "url": "https://www.uniprot.org/uniprot/Q9VX10", "type": "external" } ], "mass": 18430.0, "length": 162, "protein_name": "Sulfiredoxin", "gene_name": "Srx", "organism": "Fruit fly", "refseq_name": "sulfiredoxin, isoform A", "refseq_ac": [ { "id": "NP_573250", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573250", "type": "external" } ], "gene_names_uniprotkb": "Srx; CG6762; Dmel\\CG6762; Dmel_CG6762; Srxn; srx", "gene_names_refseq": "CG6762; Dmel\\CG6762; Srxn; Srx; srx", "protein_names_uniprotkb": "Sulfiredoxin; 1.8.98.2", "protein_names_refseq": "CG6762-PA; Srx-PA; sulfiredoxin, isoform A; sulfiredoxin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6762); (R-DME-9818027)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;33920774", "class_list": "", "function": "Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in a peroxiredoxin (PubMed:33920774). May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1B2AK28;Q4QPP8", "ec_number_list": [ { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "1.8.98.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.98.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0032542 sulfiredoxin activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0098869 cellular oxidant detoxification", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VX10-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VYA8-1", "uniprot_id": [ { "id": "TNG2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VYA8", "type": "external" } ], "mass": 31458.0, "length": 283, "protein_name": "Transport and Golgi organization protein 2", "gene_name": "Tango2", "organism": "Fruit fly", "refseq_name": "transport and golgi organization 2, isoform B", "refseq_ac": [ { "id": "NP_001245654", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245654", "type": "external" } ], "gene_names_uniprotkb": "Tango2; CG11176; Dmel\\CG11176; Dmel_CG11176; TANGO2", "gene_names_refseq": "CG11176; Dmel\\CG11176; TANGO2; Tango2", "protein_names_uniprotkb": "Transport and Golgi organization protein 2", "protein_names_refseq": "CG11176-PB; Tango2-PB; transport and golgi organization 2, isoform B", "tax_id": 7227, "disease": "TANGO2-related metabolic encephalopathy and arrythmias (Disease Ontology:DOID:0081386)", "pathway": " (dme:Dmel_CG11176)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;16452979;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "May play a role in Golgi organization., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C6SV10;Q8T0H6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0009306 protein secretion;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VYA8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VW47-1", "uniprot_id": [ { "id": "MED12_DROME", "url": "https://www.uniprot.org/uniprot/Q9VW47", "type": "external" } ], "mass": 279499.0, "length": 2531, "protein_name": "Mediator of RNA polymerase II transcription subunit 12", "gene_name": "kto", "organism": "Fruit fly", "refseq_name": "kohtalo, isoform A", "refseq_ac": [ { "id": "NP_524786", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524786", "type": "external" } ], "gene_names_uniprotkb": "kto; Brm @ Kto; CG8491; Dmel\\CG8491; Dmel_CG8491; KTO; Kto; MED12; Med12; SRB8; TRAP230; Trap230; dTRAP230; dTrap230; kto; l(3)76BDc; med12; psg14; siren1", "gene_names_refseq": "Brm @ Kto; CG8491; Dmel\\CG8491; KTO; Kto/Med12; Kto; MED12; Med12; SRB8; Srb8/KTO/TRAP230; Trap230; dTRAP230; dTrap230; kto; l(3)76BDc; med12/kto; med12; psg14; siren1", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 12; Mediator complex subunit 12; Mediator complex subunit Kohtalo; dTRAP230", "protein_names_refseq": "CG8491-PA; khotalo; kohtalo, isoform A; kohtalo; kto-PA; mediator complex subunit 12", "tax_id": 7227, "disease": "syndromic X-linked intellectual disorder Lujan-Fryns-type (Disease Ontology:DOID:0080985); major depressive disorder (Disease Ontology:DOID:1470); FG syndrome (Disease Ontology:DOID:14711); leiomyosarcoma (Disease Ontology:DOID:1967); phobic disorder (Disease Ontology:DOID:591); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG8491); (R-DME-9841922)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10731132;11171343;12537568;12537569;12537572;12537573;12537574;12835386;16110336;17290221;17372656;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for leg and eye development and macrochaete specification or differentiation., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8MQW4;Q9GPH4", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0016592 mediator complex;GO:0070847 core mediator complex;GO:0005700 polytene chromosome;GO:1990508 CKM complex", "go_biological_process": "GO:0048749 compound eye development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9VW47-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VXN9-1", "uniprot_id": [ { "id": "PGPLE_DROME", "url": "https://www.uniprot.org/uniprot/Q9VXN9", "type": "external" } ], "mass": 39426.0, "length": 345, "protein_name": "Peptidoglycan-recognition protein LE", "gene_name": "PGRP-LE", "organism": "Fruit fly", "refseq_name": "peptidoglycan recognition protein LE, isoform B", "refseq_ac": [ { "id": "NP_001245695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245695", "type": "external" } ], "gene_names_uniprotkb": "PGRP-LE; CG8995; Dmel\\CG8995; Dmel_CG8995; PGRP; anon-WO0153538.66; pgrp le; pgrp-le", "gene_names_refseq": "CG8995; Dmel\\CG8995; PGRP-LE; PGRP; anon-WO0153538.66; pgrp le; pgrp-le", "protein_names_uniprotkb": "Peptidoglycan-recognition protein LE", "protein_names_refseq": "CG8995-PB; PGRP-LE-PB; peptidoglycan recognition protein LE, isoform B; peptidoglycan recognition protein-LE", "tax_id": 7227, "disease": "lower respiratory tract disease (Disease Ontology:DOID:0050161)", "pathway": " (dme:Dmel_CG8995); (R-DME-209171); (R-DME-209266); (R-DME-214397); (R-DME-214399); (R-DME-214411); (R-DME-214416); (R-DME-6798695); (R-DME-6803157)", "pathway_count": 9, "publication_count": 23, "publication_id_list": "10731132;10934188;11018014;11106397;12359879;12433364;12537568;12537569;12537572;12537573;12537574;12732719;15538387;15657141;16110336;16428381;16767093;17569856;17569867;25589440;26109356;26109357;28539433", "class_list": "", "function": "Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to murein peptidoglycans (PGN) of Gram-negative bacteria and activating the imd/Relish pathway. Has no activity against on Gram-positive bacteria. Binds to diaminopimelic acid-type PGN (DAP-type PGN), an activator of the imd/Relish pathway. Functions synergistically with PGRP-LC in producing resistance to E.coli and B.megaterium infections, which have the DAP-type peptidoglycan. Acts both upstream and in parallel with PGRP-LC in the imd/Relish pathway, and is required for infection-dependent activation of melanization. Required for Relish processing and nuclear translocation following proteolytic cleavage. Its localization suggests a role in the recognition and subsequent activation of the signaling at the first point of contact with invading bacteria., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042834 peptidoglycan binding;GO:0008270 zinc ion binding;GO:0016019 peptidoglycan immune receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005829 cytosol", "go_biological_process": "GO:0006955 immune response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q9VXN9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VUK5-1", "uniprot_id": [ { "id": "OR71A_DROME", "url": "https://www.uniprot.org/uniprot/Q9VUK5", "type": "external" } ], "mass": 44594.0, "length": 378, "protein_name": "Putative odorant receptor 71a", "gene_name": "Or71a", "organism": "Fruit fly", "refseq_name": "odorant receptor 71a, isoform B", "refseq_ac": [ { "id": "NP_524078", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524078", "type": "external" } ], "gene_names_uniprotkb": "Or71a; 71B.1; 71a; CG17871; DOR14; DmOr71a; DmelOR71a; Dmel\\CG17871; Dmel_CG17871; OR71a; Or71aA; Or71aD; Or71c; or71a", "gene_names_refseq": "71B.1; 71a; CG17871; DOR14; DmOr71a; DmelOR71a; Dmel\\CG17871; OR71a; Or71aA; Or71aD; Or71a; Or71c; or71a", "protein_names_uniprotkb": "Putative odorant receptor 71a", "protein_names_refseq": "CG17871-PB; Or71a-PB; odorant receptor 71a, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17871)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;10943836;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IQM2", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0099094 ligand-gated monoatomic cation channel activity;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0098655 monoatomic cation transmembrane transport;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VUK5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VWK6-1", "uniprot_id": [ { "id": "PGP2L_DROME", "url": "https://www.uniprot.org/uniprot/Q9VWK6", "type": "external" } ], "mass": 36144.0, "length": 325, "protein_name": "Post-GPI attachment to proteins factor 2-like", "gene_name": "Dmel\\CG7990", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform A", "refseq_ac": [ { "id": "NP_573361", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573361", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG7990; CG7990; Dmel_CG7990", "gene_names_refseq": "CG7990; Dmel\\CG7990", "protein_names_uniprotkb": "Post-GPI attachment to proteins factor 2-like", "protein_names_refseq": "CG7990-PA; uncharacterized protein, isoform A", "tax_id": 7227, "disease": "hyperphosphatasia with impaired intellectual development syndrome 3 (Disease Ontology:DOID:0070435)", "pathway": " (dme:Dmel_CG7990)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8E770;Q8IQX1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VWK6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W0A0-1", "uniprot_id": [ { "id": "DRPR_DROME", "url": "https://www.uniprot.org/uniprot/Q9W0A0", "type": "external" } ], "mass": 113015.0, "length": 1031, "protein_name": "Protein draper", "gene_name": "drpr", "organism": "Fruit fly", "refseq_name": "draper, isoform C", "refseq_ac": [ { "id": "NP_001246549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246549", "type": "external" } ], "gene_names_uniprotkb": "drpr; BcDNA:GH03529; CED-1; CG18172; CG2086; CT41022; CT6730; DRPR; Dmel\\CG2086; Dmel_CG2086; Draper I; Draper; Drpr; Megf10", "gene_names_refseq": "BcDNA:GH03529; CED-1; CG18172; CG2086; CT41022; CT6730; DRPR; Dmel\\CG2086; Draper I; Draper; Drpr; drpr", "protein_names_uniprotkb": "Protein draper", "protein_names_refseq": "CG2086-PC; draper, isoform C; draper; drpr-PC", "tax_id": 7227, "disease": "congenital myopathy 10B (Disease Ontology:DOID:0081345); congenital myopathy 10A (Disease Ontology:DOID:0111333); neurodegenerative disease (Disease Ontology:DOID:1289); myopathy (Disease Ontology:DOID:423)", "pathway": " (dme:Dmel_CG2086); (R-DME-381426); (R-DME-446107); (R-DME-8957275)", "pathway_count": 4, "publication_count": 35, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;12765609;15342648;16110336;16772168;16772169;16772170;17569856;17569867;18432193;18455990;18984163;19707574;19890048;19927123;20577216;22426252;22992958;23337816;23420848;24412417;25111228;25589440;26028435;26109356;26109357;27212238;27347682;27498858;30802937;34860835", "class_list": "", "function": "Potently inhibits glial cell engulfment of axonal debris produced following axonal injury., [UniProtKB, PubMed]; Promotes engulfment of axonal debris by glial cells following axonal injury., [UniProtKB, PubMed]; Receptor which is involved in the phagocytosis of a variety of cells including apoptotic cells, severed and pruned axons, degenerating dendrites, salivary gland cells, germline cells and bacteria (PubMed:15342648, PubMed:16772168, PubMed:16772169, PubMed:18984163, PubMed:20577216, PubMed:22992958, PubMed:24412417). Binds to the ligand prtp which relocates from the endoplasmic reticulum to the cell surface during apoptosis (PubMed:19927123, PubMed:23337816). Ligand-binding may promote tyrosine phosphorylation mediated by Src42a, interaction with shark and subsequent activation of phagocytosis (PubMed:18432193). Also binds to the membrane phospholipid phosphatidylserine which is exposed on the surface of apoptotic cells (PubMed:23420848). Required for the phagocytosis of apoptotic cells by macrophages (PubMed:15342648). Also required for the phagocytosis of apoptotic neurons by glial cells in the embryonic nervous system (PubMed:12765609). Acts downstream of NimC4/simu in the glial phagocytosis of apoptotic neurons (PubMed:18455990). Plays a role in the glial engulfment of larval axons as part of programmed axon pruning during metamorphosis (PubMed:16772168, PubMed:16772170). Also mediates glial cell clearance of severed axons following axonal injury (PubMed:16772169, PubMed:27498858). Required for the engulfment of degenerating dendrites by epidermal cells (PubMed:24412417). Required in the ovary for the engulfment and subsequent processing of dying germline cells by follicular epithelial cells through activation of the JNK/bsk pathway (PubMed:22992958, PubMed:27347682). Plays a role in neuromuscular junction development by mediating the clearance of presynaptic debris and immature boutons which are shed by growing synapses (PubMed:19707574). Required for larval salivary gland cell death which occurs following a rise in steroid levels after puparium formation (PubMed:20577216). Also involved in bacterial phagocytosis (PubMed:18984163). Required for hemocyte phagocytosis of the Gram-positive bacterium S.aureus (PubMed:19890048). Lipoteichoic acid, synthesized by the S.aureus lipoteichoic acid synthase ltaS, acts as a ligand for drpr in this process (PubMed:19890048). Together with Src42a and shark, promotes the migration of macrophages to sites of wounding as part of a signaling cascade where Scr42a detects production of hydrogen peroxide at wound sites which triggers phosphorylation of drpr and subsequent recruitment and activation of shark (PubMed:26028435). Also required for macrophage priming which occurs following phagocytosis of apoptotic cells and ensures that macrophages develop a form of molecular memory that allows them to later mount an inflammatory response to tissue damage and bacterial infection (PubMed:27212238). Is also an essential factor in the regulation of muscle development and myogenesis, and as a consequence is required for normal locomotion (PubMed:12765609, PubMed:25111228, Ref.27). Likely to control the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway (PubMed:25111228, PubMed:30802937, Ref.27)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 14, "predicted_n_glycosites": 14, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "M9NEX8;Q1EC80;Q9W0A1", "ec_number_list": [], "go_molecular_function": "GO:0005044 scavenger receptor activity;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0016020 membrane", "go_biological_process": "GO:0006911 phagocytosis, engulfment;GO:0016322 neuron remodeling;GO:0006909 phagocytosis;GO:0009611 response to wounding;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "Q9W0A0-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VPT5-1", "uniprot_id": [ { "id": "PEX12_DROME", "url": "https://www.uniprot.org/uniprot/Q9VPT5", "type": "external" } ], "mass": 34544.0, "length": 297, "protein_name": "Peroxisome assembly protein 12", "gene_name": "Pex12", "organism": "Fruit fly", "refseq_name": "peroxin 12, isoform B", "refseq_ac": [ { "id": "NP_001259844", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259844", "type": "external" } ], "gene_names_uniprotkb": "Pex12; CG3639; DmelPex12; Dmel\\CG3639; Dmel_CG3639; PEX12; pex12", "gene_names_refseq": "CG3639; DmelPex12; Dmel\\CG3639; PEX12; Pex12; pex12", "protein_names_uniprotkb": "Peroxisome assembly protein 12; Peroxin-12", "protein_names_refseq": "CG3639-PB; Pex12-PB; peroxin 12, isoform B; peroxin 12", "tax_id": 7227, "disease": "peroxisome biogenesis disorder 3A (Disease Ontology:DOID:0080478); peroxisome biogenesis disorder 3B (Disease Ontology:DOID:0081241)", "pathway": " (dme:Dmel_CG3639); (R-DME-8866654); (R-DME-9033241); (R-DME-9603798)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;21669930;25589440;26109356;26109357", "class_list": "", "function": "Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V3Q4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:1990429 peroxisomal importomer complex;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0007031 peroxisome organization;GO:0000209 protein polyubiquitination;GO:0016558 protein import into peroxisome matrix;GO:0006513 protein monoubiquitination;GO:0016562 protein import into peroxisome matrix, receptor recycling", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VPT5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VQ36-1", "uniprot_id": [ { "id": "FRITZ_DROME", "url": "https://www.uniprot.org/uniprot/Q9VQ36", "type": "external" } ], "mass": 106066.0, "length": 951, "protein_name": "WD repeat-containing and planar cell polarity effector protein fritz", "gene_name": "frtz", "organism": "Fruit fly", "refseq_name": "fritz, isoform B", "refseq_ac": [ { "id": "NP_001259879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259879", "type": "external" } ], "gene_names_uniprotkb": "frtz; CG17657; Dmel\\CG17657; Dmel_CG17657; Frtz; anon-WO0118547.105", "gene_names_refseq": "CG17657; Dmel\\CG17657; Frtz; anon-WO0118547.105; frtz", "protein_names_uniprotkb": "WD repeat-containing and planar cell polarity effector protein fritz", "protein_names_refseq": "CG17657-PB; fritz, isoform B; frtz-PB", "tax_id": 7227, "disease": "Bardet-Biedl syndrome 15 (Disease Ontology:DOID:0110137); congenital heart defects, hamartomas of tongue, and polysyndactyly (Disease Ontology:DOID:0111591); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (dme:Dmel_CG17657); (R-DME-450728)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;15556868;15654087;16110336;17569856;17569867;18701542;18723886;19576201;25589440;26109356;26109357", "class_list": "", "function": "Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Functions cell autonomously to regulate wing cell hair polarity and number., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0097541 axonemal basal plate;GO:0005930 axoneme", "go_biological_process": "GO:0007399 nervous system development;GO:0045184 establishment of protein localization;GO:0044782 cilium organization;GO:0035320 imaginal disc-derived wing hair site selection;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9VQ36-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VTU3-1", "uniprot_id": [ { "id": "RG68F_DROME", "url": "https://www.uniprot.org/uniprot/Q9VTU3", "type": "external" } ], "mass": 54969.0, "length": 476, "protein_name": "Rho GTPase-activating protein 68F", "gene_name": "RhoGAP68F", "organism": "Fruit fly", "refseq_name": "Rho GTPase activating protein at 68F, isoform D", "refseq_ac": [ { "id": "NP_001261744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261744", "type": "external" } ], "gene_names_uniprotkb": "RhoGAP68F; CG 6811; CG6811; Dmel\\CG6811; Dmel_CG6811; RhoGAP", "gene_names_refseq": "CG 6811; CG6811; Dmel\\CG6811; RhoGAP68F; RhoGAP", "protein_names_uniprotkb": "Rho GTPase-activating protein 68F", "protein_names_refseq": "CG6811-PD; Rho GTPase activating protein at 68F, isoform D; RhoGAP68F-PD", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6811); (R-DME-8980692); (R-DME-9013148); (R-DME-9013149); (R-DME-9013406); (R-DME-9013409); (R-DME-9013423); (R-DME-9035034)", "pathway_count": 8, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;16609869;17372656;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Functions as a GTPase-activating protein (GAP) for RhoA/Rho1 during gastrulation by converting it to an inactive GDP-bound state., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0055037 recycling endosome", "go_biological_process": "GO:0007266 Rho protein signal transduction;GO:0007264 small GTPase-mediated signal transduction;GO:0045887 positive regulation of synaptic assembly at neuromuscular junction;GO:0051497 negative regulation of stress fiber assembly;GO:2001136 negative regulation of endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9VTU3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VU65-1", "uniprot_id": [ { "id": "POC1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VU65", "type": "external" } ], "mass": 42810.0, "length": 391, "protein_name": "POC1 centriolar protein homolog", "gene_name": "Poc1", "organism": "Fruit fly", "refseq_name": "proteome of centrioles 1, isoform A", "refseq_ac": [ { "id": "NP_648640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648640", "type": "external" } ], "gene_names_uniprotkb": "Poc1; CG10191; Dmel\\CG10191; Dmel_CG10191; POC1; Pix; poc1", "gene_names_refseq": "CG10191; Dmel\\CG10191; POC1; Pix; Poc1; poc1", "protein_names_uniprotkb": "POC1 centriolar protein homolog; Proteome of centrioles 1", "protein_names_refseq": "CG10191-PA; Poc1-PA; proteome of centrioles 1, isoform A", "tax_id": 7227, "disease": "oligoasthenoteratozoospermia (Disease Ontology:DOID:0070311); cone-rod dystrophy 20 (Disease Ontology:DOID:0111026)", "pathway": " (dme:Dmel_CG10191)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;19293139;25589440;26109356;26109357", "class_list": "", "function": "Plays an important role in centriole formation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0060271 cilium assembly;GO:0007098 centrosome cycle", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VU65-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VMV6-1", "uniprot_id": [ { "id": "SELT_DROME", "url": "https://www.uniprot.org/uniprot/Q9VMV6", "type": "external" } ], "mass": 22323.0, "length": 198, "protein_name": "Thioredoxin reductase-like selenoprotein T homolog CG3887", "gene_name": "SelT", "organism": "Fruit fly", "refseq_name": "selenoprotein T, isoform B", "refseq_ac": [ { "id": "NP_001260069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260069", "type": "external" } ], "gene_names_uniprotkb": "SelT; CG3887; Dmel\\CG3887; Dmel_CG3887; SELT", "gene_names_refseq": "CG3887; Dmel\\CG3887; SELT; SelT", "protein_names_uniprotkb": "Thioredoxin reductase-like selenoprotein T homolog CG3887; 1.8.1.9", "protein_names_refseq": "CG3887-PB; SelT-PB; SelT-like protein; selenoprotein T, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3887)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Probably has thioredoxin reductase-like oxidoreductase activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.9", "type": "external" } ], "go_molecular_function": "GO:0004791 thioredoxin-disulfide reductase (NADPH) activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0045454 cell redox homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VMV6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VW56-1", "uniprot_id": [ { "id": "PFD6_DROME", "url": "https://www.uniprot.org/uniprot/Q9VW56", "type": "external" } ], "mass": 14428.0, "length": 125, "protein_name": "Probable prefoldin subunit 6", "gene_name": "Pfdn6", "organism": "Fruit fly", "refseq_name": "prefoldin 6, isoform B", "refseq_ac": [ { "id": "NP_001262079", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262079", "type": "external" } ], "gene_names_uniprotkb": "Pfdn6; BcDNA:GH28557; CG7770; Dmel\\CG7770; Dmel_CG7770; pfdn6", "gene_names_refseq": "BcDNA:GH28557; CG7770; Dmel\\CG7770; Pfdn6; pfdn6", "protein_names_uniprotkb": "Probable prefoldin subunit 6", "protein_names_refseq": "CG7770-PB; Pfdn6-PB; prefoldin 6, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7770)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016272 prefoldin complex", "go_biological_process": "GO:0006457 protein folding;GO:0051131 chaperone-mediated protein complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VW56-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VPF8-1", "uniprot_id": [ { "id": "S38AC_DROME", "url": "https://www.uniprot.org/uniprot/Q9VPF8", "type": "external" } ], "mass": 57567.0, "length": 509, "protein_name": "Putative sodium-coupled neutral amino acid transporter 12", "gene_name": "anon-WO0118547.347", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001262109", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262109", "type": "external" } ], "gene_names_uniprotkb": "anon-WO0118547.347; CG5262; Dmel\\CG5262; Dmel_CG5262", "gene_names_refseq": "CG5262; Dmel\\CG5262; anon-WO0118547.347", "protein_names_uniprotkb": "Putative sodium-coupled neutral amino acid transporter 12; Solute carrier family 38 member 12", "protein_names_refseq": "CG5262-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5262)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006865 amino acid transport;GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VPF8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W539-1", "uniprot_id": [ { "id": "HR4_DROME", "url": "https://www.uniprot.org/uniprot/Q9W539", "type": "external" } ], "mass": 162655.0, "length": 1518, "protein_name": "Hormone receptor 4", "gene_name": "Hr4", "organism": "Fruit fly", "refseq_name": "hormone receptor 4, isoform C", "refseq_ac": [ { "id": "NP_001033823", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033823", "type": "external" } ], "gene_names_uniprotkb": "Hr4; CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\\CG43934; Dmel_CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; HR4; NR6A2; hr4; null", "gene_names_refseq": "CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; HR4; Hr4; NR6A2; hr4; null", "protein_names_uniprotkb": "Hormone receptor 4; Nuclear receptor subfamily 6 group A member 2; dHR4", "protein_names_refseq": "CG43934-PC; Hr4-PC; hormone receptor 4, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG43934); (R-DME-383280)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10731132;10731137;12537568;12537572;12537573;12537574;15935763;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Coordinates growth and maturation by mediating endocrine responses to the attainment of critical weight during larval development. Plays a central role in the genetic cascades triggered by the steroid hormone ecdysone at the onset of metamorphosis, acting as both a repressor of the early ecdysone-induced regulatory genes and an inducer of the ftz-f1 midprepupal competence factor., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O96836;Q56AW0", "ec_number_list": [], "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0008270 zinc ion binding;GO:0004879 nuclear receptor activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0071456 cellular response to hypoxia;GO:0048638 regulation of developmental growth;GO:0040018 positive regulation of multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9W539-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W021-1", "uniprot_id": [ { "id": "RM23_DROME", "url": "https://www.uniprot.org/uniprot/Q9W021", "type": "external" } ], "mass": 17878.0, "length": 150, "protein_name": "Large ribosomal subunit protein uL23m", "gene_name": "mRpL23", "organism": "Fruit fly", "refseq_name": "mitochondrial ribosomal protein L23, isoform B", "refseq_ac": [ { "id": "NP_001137873", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137873", "type": "external" } ], "gene_names_uniprotkb": "mRpL23; BcDNA:RE49852; CG1320; Dmel\\CG1320; Dmel_CG1320; L23", "gene_names_refseq": "BcDNA:RE49852; CG1320; Dmel\\CG1320; L23; mRpL23", "protein_names_uniprotkb": "Large ribosomal subunit protein uL23m; 39S ribosomal protein L23, mitochondrial; L23mt; MRP-L23", "protein_names_refseq": "CG1320-PB; mRpL23-PB; mitochondrial ribosomal protein L23, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1320); (R-DME-5389840); (R-DME-5419276); (R-DME-9937383)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7Z0I3", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0032543 mitochondrial translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9W021-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VQE5-1", "uniprot_id": [ { "id": "PSB2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VQE5", "type": "external" } ], "mass": 23721.0, "length": 210, "protein_name": "Probable proteasome subunit beta type-2", "gene_name": "Prosbeta4R2", "organism": "Fruit fly", "refseq_name": "proteasome beta4 subunit-related 2, isoform B", "refseq_ac": [ { "id": "NP_001259950", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259950", "type": "external" } ], "gene_names_uniprotkb": "Prosbeta4R2; CG17302; Dmel\\CG17302; Dmel_CG17302; anon-WO0140519.122; beta4R2", "gene_names_refseq": "CG17302; Dmel\\CG17302; Prosbeta4R2; anon-WO0140519.122; beta4R2", "protein_names_uniprotkb": "Probable proteasome subunit beta type-2", "protein_names_refseq": "CG17302-PB; Prosbeta4R2-PB; proteasome beta4 subunit-related 2, isoform B; proteasome beta4R2 subunit", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17302)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12421421;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity., [UniProtKB, UniProtKB]; Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MRP4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0019774 proteasome core complex, beta-subunit complex;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005737 cytoplasm;GO:0005839 proteasome core complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VQE5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VRJ9-1", "uniprot_id": [ { "id": "OTU1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VRJ9", "type": "external" } ], "mass": 37823.0, "length": 347, "protein_name": "Ubiquitin thioesterase Otu1", "gene_name": "Yod1", "organism": "Fruit fly", "refseq_name": "Yod1 deubiquitinase, isoform C", "refseq_ac": [ { "id": "NP_001261436", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261436", "type": "external" } ], "gene_names_uniprotkb": "Yod1; CG4603; Dmel\\CG4603; Dmel_CG4603; Otu1; Q9VRJ9; dYOD1", "gene_names_refseq": "CG4603; Dmel\\CG4603; Otu1; Q9VRJ9; Yod1; dYOD1", "protein_names_uniprotkb": "Ubiquitin thioesterase Otu1; 3.4.19.12; Yod1 deubiquitinase", "protein_names_refseq": "CG4603-PC; Yod1 deubiquitinase, isoform C; Yod1-PC", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4603); (R-DME-5689896)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;35393473", "class_list": "", "function": "Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8T9H3", "ec_number_list": [ { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0030968 endoplasmic reticulum unfolded protein response;GO:0036503 ERAD pathway;GO:2000781 positive regulation of double-strand break repair;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VRJ9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VPB1-1", "uniprot_id": [ { "id": "ST7_DROME", "url": "https://www.uniprot.org/uniprot/Q9VPB1", "type": "external" } ], "mass": 60194.0, "length": 537, "protein_name": "Protein ST7 homolog", "gene_name": "Dmel\\CG3634", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001262124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262124", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG3634; CG3634; Dmel_CG3634", "gene_names_refseq": "CG3634; Dmel\\CG3634", "protein_names_uniprotkb": "Protein ST7 homolog", "protein_names_refseq": "CG3634-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3634)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VPB1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VP48-1", "uniprot_id": [ { "id": "RAB26_DROME", "url": "https://www.uniprot.org/uniprot/Q9VP48", "type": "external" } ], "mass": 43037.0, "length": 388, "protein_name": "Ras-related protein Rab-26", "gene_name": "Rab26", "organism": "Fruit fly", "refseq_name": "Rab26, isoform G", "refseq_ac": [ { "id": "NP_001287142", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287142", "type": "external" } ], "gene_names_uniprotkb": "Rab26; AAF51708; CG32439; CG34410; CG7605; DmRab26; Dmel\\CG34410; Dmel_CG34410; Q8IPT6; Q9VP48; rab26", "gene_names_refseq": "AAF51708; CG32439; CG34410; CG7605; DmRab26; Dmel\\CG34410; Q8IPT6; Q9VP48; Rab26; rab26", "protein_names_uniprotkb": "Ras-related protein Rab-26", "protein_names_refseq": "CG34410-PG; Rab26, isoform G; Rab26-PG", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG34410); (R-DME-6798695); (R-DME-8873719)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17018572;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Participates in exocrine secretion., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95R32", "ec_number_list": [ { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0055037 recycling endosome", "go_biological_process": "GO:0015031 protein transport;GO:0046718 symbiont entry into host cell;GO:0016192 vesicle-mediated transport;GO:0032482 Rab protein signal transduction;GO:0017157 regulation of exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VP48-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W5D4-1", "uniprot_id": [ { "id": "POMT2_DROME", "url": "https://www.uniprot.org/uniprot/Q9W5D4", "type": "external" } ], "mass": 86250.0, "length": 765, "protein_name": "Protein O-mannosyl-transferase 2", "gene_name": "tw", "organism": "Fruit fly", "refseq_name": "twisted, isoform B", "refseq_ac": [ { "id": "NP_001259102", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259102", "type": "external" } ], "gene_names_uniprotkb": "tw; CG12311; DPOMT2; DmPOMT2; Dmel\\CG12311; Dmel_CG12311; EG:34F3.7; POMT-2; POMT2; Pomt2; Tw; dPOMT2; dPomt2", "gene_names_refseq": "CG12311; DPOMT2; DmPOMT2; Dmel\\CG12311; EG:34F3.7; POMT-2; POMT2; Pomt2; Tw; dPOMT2; dPomt2; tw", "protein_names_uniprotkb": "Protein O-mannosyl-transferase 2; 2.4.1.109; DmPOMT2; Dolichyl-phosphate-mannose--protein mannosyltransferase 2; Protein twisted; dPOMT2", "protein_names_refseq": "CG12311-PB; protein O-mannosyltransferase 2; tricky-dickey; tw-PB; twisted abdomen; twisted, isoform B; twisted; twist", "tax_id": 7227, "disease": "lissencephaly (Disease Ontology:DOID:0050453); Walker-Warburg syndrome (Disease Ontology:DOID:0050560); autosomal recessive limb-girdle muscular dystrophy (Disease Ontology:DOID:0110274); autosomal recessive limb-girdle muscular dystrophy type 2N (Disease Ontology:DOID:0110298); congenital muscular dystrophy-dystroglycanopathy type A2 (Disease Ontology:DOID:0111240); muscular dystrophy-dystroglycanopathy (Disease Ontology:DOID:0112374); muscular dystrophy-dystroglycanopathy type B2 (Disease Ontology:DOID:0112380); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (dme:Dmel_CG12311); (R-DME-8932504); (R-DME-8932505); (R-DME-8932506)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "10731132;10731137;12537568;12537569;12537572;12537573;12537574;15271988;16110336;16219785;17569856;17569867;25589440;26109356;26109357", "class_list": "glycogene;glycosyltransferase", "function": "Rt/POMT1 and tw/POMT2 function as a protein O-mannosyltransferase in association with each other to generate and maintain normal muscle development., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "O77437", "ec_number_list": [ { "id": "2.4.1.109", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.109", "type": "external" } ], "go_molecular_function": "GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex", "go_biological_process": "GO:0007525 somatic muscle development;GO:0007517 muscle organ development;GO:0045214 sarcomere organization;GO:0035269 protein O-linked glycosylation via mannose", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9W5D4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W484-1", "uniprot_id": [ { "id": "RTEL1_DROME", "url": "https://www.uniprot.org/uniprot/Q9W484", "type": "external" } ], "mass": 109683.0, "length": 985, "protein_name": "Regulator of telomere elongation helicase 1 homolog", "gene_name": "Rtel1", "organism": "Fruit fly", "refseq_name": "regulator of telomere elongation helicase 1, isoform B", "refseq_ac": [ { "id": "NP_001259262", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259262", "type": "external" } ], "gene_names_uniprotkb": "Rtel1; CG4078; Dmel\\CG4078; Dmel_CG4078; dRTEL1", "gene_names_refseq": "CG4078; Dmel\\CG4078; Rtel1; dRTEL1", "protein_names_uniprotkb": "Regulator of telomere elongation helicase 1 homolog; 5.6.2.-", "protein_names_refseq": "CG4078-PB; Rtel1-PB; regulator of telomere elongation helicase 1, isoform B; regulator of telomere elongation helicase 1", "tax_id": 7227, "disease": "female breast cancer (Disease Ontology:DOID:0050671); autosomal recessive dyskeratosis congenita 5 (Disease Ontology:DOID:0070022); prostate cancer (Disease Ontology:DOID:10283); silicosis (Disease Ontology:DOID:10325); lung cancer (Disease Ontology:DOID:1324); melanoma (Disease Ontology:DOID:1909); childhood astrocytic tumor (Disease Ontology:DOID:3079); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); gastric adenocarcinoma (Disease Ontology:DOID:3717); mixed glioma (Disease Ontology:DOID:5076)", "pathway": " (dme:Dmel_CG4078)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;17989248;18327897;25589440;26109356;26109357;34644293", "class_list": "", "function": "A probable ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates (By similarity). In male germline stem cells (GSCs), plays a role in GSCs maintenance during larval germline development by modulating the expression of genes such as Stat92E and preventing DNA damage-induced checkpoint activation (PubMed:34644293). May play a role in female germline stem cell maintenance (PubMed:34644293)., [UniProtKB, HAMAP, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9YIV5;A9YIV6;A9YIW4", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.-.-.-", "type": "external" }, { "id": "5.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome", "go_biological_process": "GO:0090657 telomeric loop disassembly;GO:1904430 negative regulation of t-circle formation;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9W484-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W4S7-1", "uniprot_id": [ { "id": "MYC_DROME", "url": "https://www.uniprot.org/uniprot/Q9W4S7", "type": "external" } ], "mass": 79308.0, "length": 717, "protein_name": "Myc proto-oncogene protein", "gene_name": "Myc", "organism": "Fruit fly", "refseq_name": "Myc, isoform B", "refseq_ac": [ { "id": "NP_001259204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259204", "type": "external" } ], "gene_names_uniprotkb": "Myc; CG10798; D-Myc; DMYc; DM; Diminutive; Dmel\\CG10798; Dmel_CG10798; Dmyc; Dm; EG:BACN5I9.1; MYC; anon-WO03040301.171; bHLHe57; c-MYC; c-Myc; c-myc; cMyc; d-myc; dMYC; dMyc1; dMyc; dmyc1; dmyc; dm; l(1)G0139; l(1)G0354; l(1)G0359; myc", "gene_names_refseq": "CG10798; D-Myc; DMYc; DM; Diminutive; Dmel\\CG10798; Dmyc; Dm; EG:BACN5I9.1; MYC; Myc; anon-WO03040301.171; bHLHe57; c-MYC; c-Myc; c-myc; cMyc; d-myc; dMYC; dMyc1; dMyc; dm/dMyc; dm/myc; dmyc1; dmyc; dm; l(1)G0139; l(1)G0354; l(1)G0359; myc", "protein_names_uniprotkb": "Myc proto-oncogene protein; Protein diminutive; dMyc", "protein_names_refseq": "CG10798-PB; Myc, isoform B; Myc-PB; diminuitive; diminutive; lethal (1) G0354; lethal (1) G0359", "tax_id": 7227, "disease": "angiosarcoma (Disease Ontology:DOID:0001816); acute promyelocytic leukemia (Disease Ontology:DOID:0060318); alcohol-associated liver disease (Disease Ontology:DOID:0070658); polycystic kidney disease (Disease Ontology:DOID:0080322); polycystic kidney disease 1 (Disease Ontology:DOID:0110858); prostate cancer (Disease Ontology:DOID:10283); chronic lymphocytic leukemia (Disease Ontology:DOID:1040); urinary bladder cancer (Disease Ontology:DOID:11054); prostatic hypertrophy (Disease Ontology:DOID:11132); osteoporosis (Disease Ontology:DOID:11476); leiomyoma (Disease Ontology:DOID:127); brain cancer (Disease Ontology:DOID:1319); lung cancer (Disease Ontology:DOID:1324); hyperparathyroidism (Disease Ontology:DOID:13543); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); hepatitis C (Disease Ontology:DOID:1883); nephroblastoma (Disease Ontology:DOID:2154); prostate adenocarcinoma (Disease Ontology:DOID:2526); demyelinating disease (Disease Ontology:DOID:3213); rhabdoid cancer (Disease Ontology:DOID:3672); lung adenocarcinoma (Disease Ontology:DOID:3910); papillary thyroid carcinoma (Disease Ontology:DOID:3969); coronary restenosis (Disease Ontology:DOID:4247); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); pancreatic carcinoma (Disease Ontology:DOID:4905); liver cirrhosis (Disease Ontology:DOID:5082); prolactinoma (Disease Ontology:DOID:5394); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); Burkitt lymphoma (Disease Ontology:DOID:8584); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG10798); (R-DME-8866911)", "pathway_count": 2, "publication_count": 27, "publication_id_list": "10731132;10731137;12537568;12537569;12537572;12537573;12537574;15182669;16087886;16110336;17311883;17569856;17569867;18327897;20400939;24173801;24615015;25589440;25858587;25999153;26109356;26109357;35167135;37636057;38225354;8929412;9037036", "class_list": "", "function": "Participates in the regulation of gene transcription (PubMed:16087886, PubMed:24173801, PubMed:24615015, PubMed:25858587, PubMed:25999153, PubMed:8929412). Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence CAC[GA]TG (PubMed:8929412). Seems to activate the transcription of growth-related genes; required for cellular proliferation and growth (PubMed:16087886, PubMed:25858587, PubMed:25999153). Functions in the TORC2-mediated regulation of cell growth, acting downstream of the TORC2 complex (PubMed:25999153). Inhibits the demethylase activity of Lid (PubMed:17311883). Activates transcription of mbm (PubMed:24615015). Has a role in ribosome biogenesis and endoreplication in fat body cells by activating the transcription of LTV1 (PubMed:25858587). Able to induce the SCF E3 ubiquitin-protein ligase member archipelago (ago) which functions in its degradation (PubMed:15182669, PubMed:24173801). It may therefore create a negative feedback loop with ago that is regulated by the ubiquitin hydrolase puf (PubMed:24173801). In dopaminergic neurons, regulates dopamine levels by binding to the E-box (E1) of the dopamine decarboxylase Ddc promoter and thereby inhibiting its transcription (PubMed:35167135). This regulation is required to suppress male-male courtship (PubMed:35167135). Involved in the acs and insulin signaling mediated non-cell-autonomous induction of amino acid release into the hemolymph following the cytoplasmic purge response to intestinal bacterial infection; required for efficient recovery of enterocyte thickness (PubMed:37636057)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 35, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O96903;P91665", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0032991 protein-containing complex;GO:0035363 histone locus body", "go_biological_process": "GO:0031670 cellular response to nutrient;GO:0017126 nucleologenesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010506 regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q9W4S7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W2U4-1", "uniprot_id": [ { "id": "PP4R2_DROME", "url": "https://www.uniprot.org/uniprot/Q9W2U4", "type": "external" } ], "mass": 66809.0, "length": 609, "protein_name": "Serine/threonine-protein phosphatase 4 regulatory subunit 2", "gene_name": "PPP4R2r", "organism": "Fruit fly", "refseq_name": "protein phosphatase 4 regulatory subunit 2-related protein, isoform B", "refseq_ac": [ { "id": "NP_525083", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_525083", "type": "external" } ], "gene_names_uniprotkb": "PPP4R2r; BcDNA:LD29930; CG2890; Dmel\\CG2890; Dmel_CG2890; PP4R2r; PP4R2; PP4R; PP4r2; PPP4R2; Ppp4R2; R2", "gene_names_refseq": "BcDNA:LD29930; CG2890; Dmel\\CG2890; PP4R2r; PP4R2; PP4R; PP4r2; PPP4R2r; PPP4R2; Ppp4R2; R2", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 4 regulatory subunit 2; PPP4R2-related protein", "protein_names_refseq": "CG2890-PB; PP4 regulatory subunit; PPP4R2r-PB; protein phosphatase 4 regulatory subunit 2-related protein, isoform B; protein phosphatase 4 regulatory subunit 2-related protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2890)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;10769191;12537568;12537569;12537572;12537573;12537574;16110336;17372656;17569856;17569867;18327897;18487071;25589440;26109356;26109357", "class_list": "", "function": "Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4) (By similarity). The probable PP4 complex Pp4-19C-PPP4R2r-flfl (PPP4C-PPP4R2-PPP4R3) is required to prevent caspase induced cell death (in vitro)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q960Z5;Q9NFT0", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000775 chromosome, centromeric region;GO:0030289 protein phosphatase 4 complex", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0045879 negative regulation of smoothened signaling pathway;GO:0061060 negative regulation of peptidoglycan recognition protein signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9W2U4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W058-1", "uniprot_id": [ { "id": "SCOT_DROME", "url": "https://www.uniprot.org/uniprot/Q9W058", "type": "external" } ], "mass": 54904.0, "length": 516, "protein_name": "Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial", "gene_name": "Scot", "organism": "Fruit fly", "refseq_name": "Succinyl-CoA:3-ketoacid CoA transferase, isoform A", "refseq_ac": [ { "id": "NP_647683", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647683", "type": "external" } ], "gene_names_uniprotkb": "Scot; BcDNA:RH54340; CG1140; CT1116; DmSCOT; Dmel\\CG1140; Dmel_CG1140; SCOT; cDNA B", "gene_names_refseq": "BcDNA:RH54340; CG1140; CT1116; DmSCOT; Dmel\\CG1140; SCOT; cDNA B", "protein_names_uniprotkb": "Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial; 2.8.3.5; 3-oxoacid CoA-transferase", "protein_names_refseq": "3-oxoacid CoA-transferase; 3-oxoacid-CoA transferase; 3-oxoacid-CoA-transferase; CG1140-PA; SCOT-PA; Succinyl-CoA:3-ketoacid CoA transferase, isoform A; citric acid synthetase", "tax_id": 7227, "disease": "carbohydrate metabolic disorder (Disease Ontology:DOID:2978); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG1140); (R-DME-77108); (R-DME-9837999)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;24100554;25589440;26109356;26109357", "class_list": "", "function": "Key enzyme for ketone body catabolism (PubMed:24100554). Transfers the CoA moiety from succinate to acetoacetate (PubMed:24100554). Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity)., [UniProtKB, UniProtKB, PubMed]; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IRG3", "ec_number_list": [ { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "1.1.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.40", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "1.1.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.39", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.51", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.-.-", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "2.3.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.16", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" } ], "go_molecular_function": "GO:0008260 succinyl-CoA:3-oxo-acid CoA-transferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0046952 ketone body catabolic process;GO:1902224 ketone body metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9W058-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VYF2-1", "uniprot_id": [ { "id": "IMPA3_DROME", "url": "https://www.uniprot.org/uniprot/Q9VYF2", "type": "external" } ], "mass": 39336.0, "length": 355, "protein_name": "Putative inositol monophosphatase 3", "gene_name": "Dmel\\CG15743", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001259511", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259511", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG15743; CG15743; Dmel_CG15743", "gene_names_refseq": "CG15743; Dmel\\CG15743", "protein_names_uniprotkb": "Putative inositol monophosphatase 3; 3.1.3.25; IMP 3; IMPase 3; Inositol-1(or 4)-monophosphatase 3; Myo-inositol monophosphatase A3", "protein_names_refseq": "CG15743-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "chondrodysplasia with joint dislocations gPAPP type (Disease Ontology:DOID:0112224)", "pathway": " (dme:Dmel_CG15743); (R-DME-156584)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.25", "type": "external" } ], "go_molecular_function": "GO:0008254 3'-nucleotidase activity;GO:0052834 inositol monophosphate phosphatase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0006021 inositol biosynthetic process;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VYF2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VXX8-1", "uniprot_id": [ { "id": "RL371_DROME", "url": "https://www.uniprot.org/uniprot/Q9VXX8", "type": "external" } ], "mass": 10643.0, "length": 93, "protein_name": "Large ribosomal subunit protein eL37A", "gene_name": "RpL37-1", "organism": "Fruit fly", "refseq_name": "ribosomal protein L37-1, isoform B", "refseq_ac": [ { "id": "NP_001259561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259561", "type": "external" } ], "gene_names_uniprotkb": "RpL37-1; CG9091; Dmel\\CG9091; Dmel_CG9091; L37e; RpL37A; RpL37a; RpL37", "gene_names_refseq": "CG9091; Dmel\\CG9091; L37e; RpL37-1; RpL37A; RpL37a; RpL37", "protein_names_uniprotkb": "Large ribosomal subunit protein eL37A; Probable 60S ribosomal protein L37-A; Ribosomal protein L37-1", "protein_names_refseq": "CG9091-PB; RpL37-1-PB; ribosomal protein L37-1, isoform B; ribosomal protein L37a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9091); (R-DME-156827); (R-DME-1799339); (R-DME-72689); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954709); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 10, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;23636399;25589440;26109356;26109357", "class_list": "", "function": "Binds to the 23S rRNA., [UniProtKB, UniProtKB, UniProtKB]; Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8E7A3", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022626 cytosolic ribosome;GO:0022625 cytosolic large ribosomal subunit;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VXX8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VWF2-1", "uniprot_id": [ { "id": "SAYP_DROME", "url": "https://www.uniprot.org/uniprot/Q9VWF2", "type": "external" } ], "mass": 212726.0, "length": 2006, "protein_name": "Supporter of activation of yellow protein", "gene_name": "e(y)3", "organism": "Fruit fly", "refseq_name": "enhancer of yellow 3, isoform B", "refseq_ac": [ { "id": "NP_001259718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259718", "type": "external" } ], "gene_names_uniprotkb": "e(y)3; CG12238; Dmel\\CG12238; Dmel_CG12238; E(y)3; SAYP; e(y)[3]; l(1)G0084; l(1)G0266; l(1)G0283; l(1)G0381; l(1)G0409; sayp", "gene_names_refseq": "CG12238; Dmel\\CG12238; E(y)3; SAYP; e(y)3; e(y)[3]; l(1)G0084; l(1)G0266; l(1)G0283; l(1)G0381; l(1)G0409; sayp", "protein_names_uniprotkb": "Supporter of activation of yellow protein; Protein enhancer of yellow 3", "protein_names_refseq": "CG12238-PB; SAYP; e(y)3-PB; enhancer of yellow 3, isoform B; lethal (1) G0084; supporter of activation of yellow protein", "tax_id": 7227, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); Coffin-Siris syndrome (Disease Ontology:DOID:1925)", "pathway": " (dme:Dmel_CG12238)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15616585;16110336;17569856;17569867;25589440;26109356;26109357;40245499", "class_list": "", "function": "Essential transcription regulator during early development. Coactivates transcription of some euchromatin genes and repress transcription in of euchromatin genes translocated to heterochromatin., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "C7LAD9;Q7JW70", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000791 euchromatin;GO:0000792 heterochromatin;GO:0035060 brahma complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9VWF2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VS34-1", "uniprot_id": [ { "id": "RL18_DROME", "url": "https://www.uniprot.org/uniprot/Q9VS34", "type": "external" } ], "mass": 21665.0, "length": 188, "protein_name": "Large ribosomal subunit protein eL18", "gene_name": "RpL18", "organism": "Fruit fly", "refseq_name": "ribosomal protein L18, isoform B", "refseq_ac": [ { "id": "NP_001261501", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261501", "type": "external" } ], "gene_names_uniprotkb": "RpL18; CG8615; Dmel\\CG8615; Dmel_CG8615; L18e; Rp L18; RpL18e", "gene_names_refseq": "CG8615; Dmel\\CG8615; L18e; Rp L18; RpL18e; RpL18", "protein_names_uniprotkb": "Large ribosomal subunit protein eL18; 60S ribosomal protein L18", "protein_names_refseq": "CG8615-PB; RpL18-PB; ribosomal protein L18, isoform B", "tax_id": 7227, "disease": "Diamond-Blackfan anemia 18 (Disease Ontology:DOID:0111896); Diamond-Blackfan anemia (Disease Ontology:DOID:1339)", "pathway": " (dme:Dmel_CG8615); (R-DME-156827); (R-DME-1799339); (R-DME-72689); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954709); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 10, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;23636399;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022626 cytosolic ribosome;GO:0022625 cytosolic large ribosomal subunit;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VS34-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VUX2-1", "uniprot_id": [ { "id": "MIB_DROME", "url": "https://www.uniprot.org/uniprot/Q9VUX2", "type": "external" } ], "mass": 129872.0, "length": 1226, "protein_name": "E3 ubiquitin-protein ligase mind-bomb", "gene_name": "mib1", "organism": "Fruit fly", "refseq_name": "mind bomb 1, isoform A", "refseq_ac": [ { "id": "NP_648826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648826", "type": "external" } ], "gene_names_uniprotkb": "mib1; 2; CG5841; D-mib1; D-mib; Dmel\\CG5841; Dmel_CG5841; Dmib; MIB1; Mib1; Mib; dmib1; l(3)72CDa; l(3)72Db; mib; mind-bomb", "gene_names_refseq": "CG5841; D-mib1; D-mib; Dmel\\CG5841; Dmib; MIB1; Mib1; Mib; dmib1; l(3)72CDa; l(3)72Db; mib1/2; mib1; mib; mind-bomb", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase mind-bomb; 2.3.2.27; D-mib; Mind bomb homolog; Protein mind bob 1; RING-type E3 ubiquitin transferase mind-bomb", "protein_names_refseq": "CG5841-PA; Mib1; Mindbomb1; lethal (3) 72CDa; lethal (3) 72Db; mib1-PA; mind bomb 1, isoform A; mind bomb 1; mind bomb-1; mind bomb1; mind bomb; mind-bomb; mindbomb 1; mindbomb", "tax_id": 7227, "disease": "left ventricular noncompaction (Disease Ontology:DOID:0060480); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dme:Dmel_CG5841)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15760269;15829515;16110336;17569856;17569867;20176925;25589440;26109356;26109357", "class_list": "", "function": "E3 ubiquitin-protein ligase involved in regulation of Notch signaling (PubMed:15760269, PubMed:15829515, PubMed:20176925). Ubiquitinates the intracellular domains of Notch ligands Dl/delta and Ser/serrate, leading to their endocytosis and degradation (PubMed:15760269, PubMed:15829515, PubMed:20176925). Regulates a subset of Notch signaling events, including wing margin specification, leg segmentation and vein determination, that are distinct from those events requiring neuralize (neur) activity (PubMed:15760269, PubMed:15829515, PubMed:20176925). Also modulates lateral inhibition, a neur- and Dl-dependent signaling event, suggesting a distinct but partially complementary function with neur (PubMed:15760269, PubMed:15829515). Involved in the development of sensory organ precursors and wings (PubMed:15829515)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MSR3", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0045179 apical cortex;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046331 lateral inhibition;GO:0006897 endocytosis;GO:0007219 Notch signaling pathway;GO:0045747 positive regulation of Notch signaling pathway;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9VUX2-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VV73-1", "uniprot_id": [ { "id": "NXF2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VV73", "type": "external" } ], "mass": 96635.0, "length": 841, "protein_name": "Nuclear RNA export factor 2", "gene_name": "nxf2", "organism": "Fruit fly", "refseq_name": "nuclear RNA export factor 2, isoform A", "refseq_ac": [ { "id": "NP_524111", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524111", "type": "external" } ], "gene_names_uniprotkb": "nxf2; CG4118; Dmel\\CG4118; Dmel_CG4118; NXF2; Nxf2; dNxf2", "gene_names_refseq": "CG4118; Dmel\\CG4118; NXF2; Nxf2; dNxf2; nxf2", "protein_names_uniprotkb": "Nuclear RNA export factor 2", "protein_names_refseq": "CG4118-PA; Nxf2; nuclear RNA export factor 2, isoform A; nxf2-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4118); (R-DME-159236)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10731132;11780633;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;31219034;31368590;31384064;31570835", "class_list": "", "function": "May be involved in the export of mRNA from the nucleus to the cytoplasm (PubMed:11780633). In the ovaries, forms a complex with nxf2, piwi and Nxt1 which acts as effectors of cotranscriptional transposon silencing (PubMed:31219034, PubMed:31368590, PubMed:31384064, PubMed:31570835). On recruitment to a target transcript, interacts with single stranded RNA, thereby anchoring the complex via the nascent target transcript to chromatin and allowing Panx to recruit silencing effectors to establishing repressive heterochromatin at transposon loci (PubMed:31368590, PubMed:31384064, PubMed:31570835). Does not affect piRNA biogenesis (PubMed:31384064). The interaction with Panx stabilizes the nuclear protein complex (PubMed:31384064). Does not bind nucleoporins, but regulates sbr/Nxf1 binding to nucleoporins and, indirectly, transposon exports (PubMed:31384064, PubMed:31570835)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0E8E0", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003727 single-stranded RNA binding;GO:0140463 chromatin-protein adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0017053 transcription repressor complex;GO:0090571 RNA polymerase II transcription repressor complex", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0031507 heterochromatin formation;GO:1990139 protein localization to nuclear periphery;GO:0141006 transposable element silencing by piRNA-mediated heterochromatin formation;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9VV73-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W0Y1-1", "uniprot_id": [ { "id": "TINA1_DROME", "url": "https://www.uniprot.org/uniprot/Q9W0Y1", "type": "external" } ], "mass": 19056.0, "length": 167, "protein_name": "Troponin C-akin-1 protein", "gene_name": "Tina-1", "organism": "Fruit fly", "refseq_name": "troponin C-akin-1, isoform B", "refseq_ac": [ { "id": "NP_001033974", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033974", "type": "external" } ], "gene_names_uniprotkb": "Tina-1; BEST:GM14784; CG2803; Dmel\\CG2803; Dmel_CG2803", "gene_names_refseq": "BEST:GM14784; CG2803; Dmel\\CG2803; Tina-1", "protein_names_uniprotkb": "Troponin C-akin-1 protein; 2.3.2.-; Putative gamma-glutamylcyclotransferase", "protein_names_refseq": "CG2803-PB; Tina-1-PB; troponin C-akin-1, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2803)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12397110;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Putative gamma-glutamylcyclotransferase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95T30", "ec_number_list": [], "go_molecular_function": "GO:0061929 gamma-glutamylaminecyclotransferase activity;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9W0Y1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W0G1-1", "uniprot_id": [ { "id": "PTP61_DROME", "url": "https://www.uniprot.org/uniprot/Q9W0G1", "type": "external" } ], "mass": 62105.0, "length": 548, "protein_name": "Tyrosine-protein phosphatase non-receptor type 61F", "gene_name": "Ptp61F", "organism": "Fruit fly", "refseq_name": "protein tyrosine phosphatase 61F, isoform A", "refseq_ac": [ { "id": "NP_476687", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476687", "type": "external" } ], "gene_names_uniprotkb": "Ptp61F; BEST:LP01280; CG9178; CG9181; CPtp62A; DCPTP62A; DPTP61F; Dmel\\CG9181; Dmel_CG9181; PTP1B; PTP1b; PTP61F; Ptp-61F; Ptp61f; R-PTP 61F; anon-WO0118547.297; anon-WO0140519.98; dPTP61F; dptp61F; ptp61F", "gene_names_refseq": "BEST:LP01280; CG9178; CG9181; CPtp62A; DCPTP62A; DPTP61F; Dmel\\CG9181; PTP1B; PTP1b; PTP61F; Ptp-61F; Ptp61F; Ptp61f; R-PTP 61F; anon-WO0118547.297; anon-WO0140519.98; dPTP61F; dptp61F; ptp61F", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 61F; 3.1.3.48; dPTP61F", "protein_names_refseq": "CG9181-PA; Ptp61F-PA; cytoplasmic protein tyrosine phosphatase 62A; protein tyrosine phosphatase 61F, isoform A; protein tyrosine phosphatase 61F; protein-tyrosine-phosphatase", "tax_id": 7227, "disease": "intestinal cancer (Disease Ontology:DOID:10155); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); hyperinsulinism (Disease Ontology:DOID:2018); coronary artery disease (Disease Ontology:DOID:3393); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dme:Dmel_CG9181); (R-DME-77387); (R-DME-877312); (R-DME-9833482); (R-DME-9860927)", "pathway_count": 5, "publication_count": 18, "publication_id_list": "10731132;12014990;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;21707536;25589440;26109356;26109357;8463208;8663600;9256342", "class_list": "", "function": "Non-receptor protein tyrosine phosphatase (PubMed:8463208). Required for maintaining dock/dreadlocks in its non-phosphorylated state (PubMed:12014990). Negative regulator of InR/insulin-like receptor signaling through dephosphorylation of tyrosines when recruited by dock/dreadlocks (PubMed:21707536)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q27932;Q8SZY3;Q9W0G2", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0004726 non-membrane spanning protein tyrosine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005740 mitochondrial envelope;GO:0005829 cytosol", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0046621 negative regulation of organ growth;GO:0000278 mitotic cell cycle;GO:0008285 negative regulation of cell population proliferation;GO:0071456 cellular response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9W0G1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VMX0-1", "uniprot_id": [ { "id": "RM28_DROME", "url": "https://www.uniprot.org/uniprot/Q9VMX0", "type": "external" } ], "mass": 34950.0, "length": 302, "protein_name": "Large ribosomal subunit protein bL28m", "gene_name": "mRpL28", "organism": "Fruit fly", "refseq_name": "mitochondrial ribosomal protein L28, isoform B", "refseq_ac": [ { "id": "NP_001260063", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260063", "type": "external" } ], "gene_names_uniprotkb": "mRpL28; CG3782", "gene_names_refseq": "CG3782; Dmel\\CG3782; MRP-L28; mRpL28", "protein_names_uniprotkb": "Large ribosomal subunit protein bL28m; 39S ribosomal protein L28, mitochondrial; L28mt; MRP-L28", "protein_names_refseq": "CG3782-PB; ecdysteroid regulated 16kd protein; mRpL28-PB; mitochondrial ribosomal protein L28, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3782); (R-DME-5389840); (R-DME-5419276); (R-DME-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SXZ1", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VMX0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VMX3-1", "uniprot_id": [ { "id": "Q9VMX3_DROME", "url": "https://www.uniprot.org/uniprot/Q9VMX3", "type": "external" } ], "mass": 38138.0, "length": 333, "protein_name": "DNA-directed RNA polymerases I and III subunit RPAC1", "gene_name": "Polr1C", "organism": "Fruit fly", "refseq_name": "RNA polymerase I and III subunit C", "refseq_ac": [ { "id": "NP_608885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608885", "type": "external" } ], "gene_names_uniprotkb": "Polr1C; AC40; CG3756; Dmel\\CG3756; Dmel_CG3756; POLR1C; RPC40", "gene_names_refseq": "AC40; CG3756; Dmel\\CG3756; POLR1C; Polr1C; RPC40", "protein_names_uniprotkb": "DNA-directed RNA polymerases I and III subunit RPAC1", "protein_names_refseq": "CG3756-PA; Polr1C-PA; RNA polymerase I and III subunit C", "tax_id": 7227, "disease": "hypomyelinating leukodystrophy 11 (Disease Ontology:DOID:0060792); Treacher Collins syndrome 3 (Disease Ontology:DOID:0080791); Treacher Collins syndrome (Disease Ontology:DOID:2908)", "pathway": " (dme:Dmel_CG3756); (R-DME-73762); (R-DME-73772); (R-DME-76061); (R-DME-76066)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005736 RNA polymerase I complex;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0042797 tRNA transcription by RNA polymerase III;GO:0006362 transcription elongation by RNA polymerase I;GO:0006383 transcription by RNA polymerase III;GO:0006386 termination of RNA polymerase III transcription", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VMX3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VMX6-1", "uniprot_id": [ { "id": "SMAL1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VMX6", "type": "external" } ], "mass": 84568.0, "length": 755, "protein_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1", "gene_name": "Marcal1", "organism": "Fruit fly", "refseq_name": "Marcal1", "refseq_ac": [ { "id": "NP_608883", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608883", "type": "external" } ], "gene_names_uniprotkb": "Marcal1; CG3753", "gene_names_refseq": "CG3753; Dmel\\CG3753; HARP; MARCAL1; Marca1; Marcal1; dmHARP", "protein_names_uniprotkb": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; 3.6.4.-", "protein_names_refseq": "CG3753-PA; Marcal1-PA; Marcal1; dsmarcal1; hepA-related protein", "tax_id": 7227, "disease": "Schimke immuno-osseous dysplasia (Disease Ontology:DOID:0060490)", "pathway": " (dme:Dmel_CG3753)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;18327897", "class_list": "", "function": "ATP-dependent annealing helicase that catalyzes the rewinding of the stably unwound DNA., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0036310 ATP-dependent DNA/DNA annealing activity;GO:0009378 four-way junction helicase activity", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005705 polytene chromosome interband", "go_biological_process": "GO:0006281 DNA repair;GO:0006357 regulation of transcription by RNA polymerase II;GO:0031297 replication fork processing;GO:0010709 heteroduplex formation involved in double-strand break repair via synthesis-dependent strand annealing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VMX6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VN03-1", "uniprot_id": [ { "id": "SUV3_DROME", "url": "https://www.uniprot.org/uniprot/Q9VN03", "type": "external" } ], "mass": 86625.0, "length": 763, "protein_name": "ATP-dependent RNA helicase SUV3 homolog, mitochondrial", "gene_name": "Suv3", "organism": "Fruit fly", "refseq_name": "Suv3 helicase, isoform D", "refseq_ac": [ { "id": "NP_001303458", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303458", "type": "external" } ], "gene_names_uniprotkb": "Suv3; CG9791", "gene_names_refseq": "CG9791; Dmel\\CG9791; SUV3; Suv3; dmsuv3", "protein_names_uniprotkb": "ATP-dependent RNA helicase SUV3 homolog, mitochondrial; 3.6.4.13", "protein_names_refseq": "CG9791-PD; SUV3 helicase; Suv3 helicase, isoform D; Suv3-PD", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9791)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;26152302", "class_list": "", "function": "Major helicase player in mitochondrial RNA metabolism and maintenance (PubMed:26152302). Likely component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner (By similarity). ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction (By similarity). Regulates mRNA stability and is required for the correct processing and maturation of mitochondrial transcripts (PubMed:26152302)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "H1UUI2;Q95TU1", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.-.-.-", "type": "external" }, { "id": "5.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003678 DNA helicase activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0045025 mitochondrial degradosome", "go_biological_process": "GO:0000963 mitochondrial RNA processing;GO:0000957 mitochondrial RNA catabolic process;GO:0000965 mitochondrial RNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VN03-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VN13-1", "uniprot_id": [ { "id": "SFXN1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VN13", "type": "external" } ], "mass": 35744.0, "length": 321, "protein_name": "Sideroflexin-1-3", "gene_name": "Sfxn1-3", "organism": "Fruit fly", "refseq_name": "sideroflexin 1/3, isoform A", "refseq_ac": [ { "id": "NP_649460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649460", "type": "external" } ], "gene_names_uniprotkb": "Sfxn1-3; CG11739", "gene_names_refseq": "CG11739; Dmel\\CG11739; Sfxn1-3; Sfxn3; anon-EST:Posey55", "protein_names_uniprotkb": "Sideroflexin-1-3", "protein_names_refseq": "CG11739-PA; Sfxn1-3-PA; sideroflexin 1/3, isoform A; sideroflexin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11739)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;30442778", "class_list": "", "function": "Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015194 L-serine transmembrane transporter activity;GO:0015075 monoatomic ion transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006730 one-carbon metabolic process;GO:1990542 mitochondrial transmembrane transport;GO:0140300 serine import into mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VN13-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VN41-1", "uniprot_id": [ { "id": "SLX1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VN41", "type": "external" } ], "mass": 34092.0, "length": 297, "protein_name": "Structure-specific endonuclease subunit SLX1 homolog", "gene_name": "slx1", "organism": "Fruit fly", "refseq_name": "nuclease slx1", "refseq_ac": [ { "id": "NP_649484", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649484", "type": "external" } ], "gene_names_uniprotkb": "slx1; CG18271", "gene_names_refseq": "CG18271; Dmel\\CG18271; SLX1; Slx1; slx1", "protein_names_uniprotkb": "Structure-specific endonuclease subunit SLX1 homolog; 3.1.-.-", "protein_names_refseq": "CG18271-PB; nuclease slx1; slx1-PB", "tax_id": 7227, "disease": "Fanconi-like syndrome (Disease Ontology:DOID:0090066)", "pathway": " (dme:Dmel_CG18271)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;19595722;19596236", "class_list": "", "function": "Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q058Y9", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004520 DNA endonuclease activity;GO:0008821 crossover junction DNA endonuclease activity;GO:0017108 5'-flap endonuclease activity", "go_cellular_component": "GO:0033557 Slx1-Slx4 complex", "go_biological_process": "GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VN41-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VN77-1", "uniprot_id": [ { "id": "Q9VN77_DROME", "url": "https://www.uniprot.org/uniprot/Q9VN77", "type": "external" } ], "mass": 59794.0, "length": 515, "protein_name": "Geranylgeranyl transferase type-2 subunit alpha", "gene_name": "RabGGTa", "organism": "Fruit fly", "refseq_name": "Rab geranylgeranyltransferase subunit alpha", "refseq_ac": [ { "id": "NP_649512", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649512", "type": "external" } ], "gene_names_uniprotkb": "RabGGTa; CG12007; Dmel\\CG12007; Dmel_CG12007; PTAR3; RabGGTalpha", "gene_names_refseq": "CG12007; Dmel\\CG12007; PTAR3; RabGGTalpha; RabGGTa", "protein_names_uniprotkb": "Geranylgeranyl transferase type-2 subunit alpha; 2.5.1.60; Geranylgeranyl transferase type II subunit alpha", "protein_names_refseq": "CG12007-PA; Rab geranylgeranyltransferase subunit alpha; RabGGTa-PA", "tax_id": 7227, "disease": "Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753)", "pathway": " (dme:Dmel_CG12007); (R-DME-6803205); (R-DME-8873719)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.5.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.59", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" } ], "go_molecular_function": "GO:0004663 Rab geranylgeranyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005968 Rab-protein geranylgeranyltransferase complex", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0097354 prenylation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VN77-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VNA5-1", "uniprot_id": [ { "id": "PSB4_DROME", "url": "https://www.uniprot.org/uniprot/Q9VNA5", "type": "external" } ], "mass": 29986.0, "length": 268, "protein_name": "Proteasome subunit beta type-4", "gene_name": "Prosbeta7", "organism": "Fruit fly", "refseq_name": "proteasome beta7 subunit, isoform A", "refseq_ac": [ { "id": "NP_649529", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649529", "type": "external" } ], "gene_names_uniprotkb": "Prosbeta7; CG12000; Prosb4; Prosbeta4", "gene_names_refseq": "12000; 154275_at; Beta-7; CG12000; Dmel\\CG12000; GC12000; Prosbeta4; Prosbeta7; Prot. beta4; anon-WO0118547.326; beta-4; beta-7; beta7", "protein_names_uniprotkb": "Proteasome subunit beta type-4; Proteasome subunit beta type-7", "protein_names_refseq": "CG12000-PA; Prosbeta4; Prosbeta7-PA; beta-type 4 subunit; beta7; proteasome beta4 subunit; proteasome beta7 subunit, isoform A", "tax_id": 7227, "disease": "proteasome-associated autoinflammatory syndrome 3 (Disease Ontology:DOID:0060916)", "pathway": " (dme:Dmel_CG12000); (R-DME-1169091); (R-DME-1234176); (R-DME-1236974); (R-DME-1236978); (R-DME-174084); (R-DME-174154); (R-DME-174178); (R-DME-174184); (R-DME-187577); (R-DME-195253); (R-DME-202424); (R-DME-209360); (R-DME-209406); (R-DME-209461); (R-DME-216167); (R-DME-2467813); (R-DME-2871837); (R-DME-350562); (R-DME-382556); (R-DME-432395); (R-DME-432524); (R-DME-432626); (R-DME-450408); (R-DME-4608870); (R-DME-4641257); (R-DME-4641258); (R-DME-5358346); (R-DME-538864); (R-DME-5607761); (R-DME-5607764); (R-DME-5610780); (R-DME-5610785); (R-DME-5632684); (R-DME-5658442); (R-DME-5676590); (R-DME-5689603); (R-DME-5689880); (R-DME-68867); (R-DME-68949); (R-DME-69017); (R-DME-69601); (R-DME-75815); (R-DME-8854050); (R-DME-8939236); (R-DME-8939902); (R-DME-8941858); (R-DME-8948751); (R-DME-8951664); (R-DME-9020702); (R-DME-9755511); (R-DME-9762114); (R-DME-983168); (R-DME-9907900); (R-DME-9912633); (R-DME-9929491); (R-DME-9932298); (R-DME-9954709)", "pathway_count": 58, "publication_count": 36, "publication_id_list": "10102270;10417378;10458606;10481010;10731132;11585911;12231619;12432393;12442174;12537569;12537572;12973300;15178801;15258584;15331761;16139204;16299518;16326393;16386907;16543224;16603629;16651542;16740475;16794082;17102630;17412918;17925225;18519643;18593878;19185492;7705656;8948598;9025065;9215627;9553105;9990853", "class_list": "", "function": "Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V2F4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0019774 proteasome core complex, beta-subunit complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000502 proteasome complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0007098 centrosome cycle", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "Q9VNA5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VNB5-1", "uniprot_id": [ { "id": "ORCO_DROME", "url": "https://www.uniprot.org/uniprot/Q9VNB5", "type": "external" } ], "mass": 54413.0, "length": 486, "protein_name": "Odorant receptor coreceptor", "gene_name": "Orco", "organism": "Fruit fly", "refseq_name": "odorant receptor co-receptor, isoform B", "refseq_ac": [ { "id": "NP_001097687", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097687", "type": "external" } ], "gene_names_uniprotkb": "Orco; A45; CG10609; Or83b", "gene_names_refseq": "83A.2; 83b; A45; CG10609; DOR45; DOR83b; DmORCO; DmOrco; DmelOrco; Dmel\\CG10609; OR49; OR83B; OR83b; ORCO; Or83b; OrCo; Orco; or83b; orco; vainsA", "protein_names_uniprotkb": "Odorant receptor coreceptor; Odorant receptor 83b", "protein_names_refseq": "CG10609-PB; Or83b; Orco-PB; odorant receptor 83b; odorant receptor co-receptor, isoform B; odorant receptor co-receptor; odorant receptor coreceptor; olfactory co-receptor; olfactory coreceptor; olfactory receptor co-receptor", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10609)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10089887;10731132;10943836;12537572;15339651;15592462;16402857;17943085;18005664;18408711;18408712;20147286;21677030;21720521;21937991;28871035", "class_list": "", "function": "Odorant coreceptor which complexes with conventional odorant receptors (ORs) to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Orco is a universal and integral part of the functional odorant receptor, involved in the dendritic localization of other olfactory receptors. Expression of Orco alone leads to formation of rapid and transient ion channels not directly responding to odorants, but directly activated by intracellular cAMP or cGMP. Snmp, Or67d and lush act in concert to capture fatty-acid-derived male pheromone 11-cis vaccenyl acetate (cVA) molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A8JQT8;Q672R0", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0015026 coreceptor activity;GO:0042803 protein homodimerization activity;GO:0004984 olfactory receptor activity;GO:0015278 intracellularly gated calcium channel activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0030425 dendrite;GO:0032590 dendrite membrane", "go_biological_process": "GO:0042048 olfactory behavior;GO:0048149 behavioral response to ethanol;GO:0032880 regulation of protein localization;GO:0007608 sensory perception of smell;GO:0019236 response to pheromone", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9VNB5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VNE1-1", "uniprot_id": [ { "id": "POLZ2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VNE1", "type": "external" } ], "mass": 23147.0, "length": 198, "protein_name": "DNA polymerase zeta subunit 2", "gene_name": "PolZ2", "organism": "Fruit fly", "refseq_name": "DNA polymerase zeta subunit 2", "refseq_ac": [ { "id": "NP_649555", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649555", "type": "external" } ], "gene_names_uniprotkb": "PolZ2; CG2948; Rev7; mad2B", "gene_names_refseq": "CG2948; DmREV7; Dmel\\CG2948; PolZ2; Rev7; mad2B; rev7", "protein_names_uniprotkb": "DNA polymerase zeta subunit 2; DNA polymerase zeta Rev7 subunit; DNA polymerase zeta processivity subunit; Revertibility protein 7", "protein_names_refseq": "CG2948-PA; DNA polymerase zeta Rev7 subunit; DNA polymerase zeta subunit 2; PolZ2-PA; rev7", "tax_id": 7227, "disease": "Fanconi anemia complementation group V (Disease Ontology:DOID:0111080)", "pathway": " (dme:Dmel_CG2948); (R-DME-110312); (R-DME-5655862); (R-DME-5656121); (R-DME-5656169)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "10731132;12537572;15175013;16507570", "class_list": "", "function": "As the accessory component of the DNA polymerase zeta complex, involved in translesion DNA synthesis (TLS) and various DNA repair mechanisms (PubMed:15175013, PubMed:16507570). Promotes the apurinic/apyrimidinic (AP) endonuclease activity of Rrp1 and is therefore likely to be involved in the base excision repair (BER) pathway responsible for repair of DNA lesions (PubMed:16507570). It does not appear to influence the synthesis activity of the catalytic component Dmpol-zeta (PubMed:15175013)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B3LF70", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0016035 zeta DNA polymerase complex", "go_biological_process": "GO:0006281 DNA repair;GO:0042276 error-prone translesion synthesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VNE1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VNE2-1", "uniprot_id": [ { "id": "PKRA_DROME", "url": "https://www.uniprot.org/uniprot/Q9VNE2", "type": "external" } ], "mass": 49225.0, "length": 422, "protein_name": "Protein krasavietz", "gene_name": "kra", "organism": "Fruit fly", "refseq_name": "krasavietz, isoform G", "refseq_ac": [ { "id": "NP_524238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524238", "type": "external" } ], "gene_names_uniprotkb": "kra; CG2922; eIF-5C; ecp; exba", "gene_names_refseq": "5MP; CG2922; CT7240; Decp; Dmel\\CG2922; ECP; Ecp; Exba; Kra; anon-WO0172774.49; chr3R:1423015..1423173; eIF-5C; eIF-5c; eIF5C; eIF5c; eIF5; eIF; eIf-5c; ecp; eiF-5C; elF-5C; elF5C; elf-5C; exba/kra; exba; kra; l(3)03022; l(3)j9B6", "protein_names_uniprotkb": "Protein krasavietz; Decp; Eukaryotic translation initiation factor 5C domain-containing protein; Protein extra bases; eIF5C domain-containing protein", "protein_names_refseq": "CG2922-PG; drosophila eIF5C-containing protein; eIF5-mimic protein; eukaryotic initiation factor 5C; extra bases; extra bses; extra-bases; kra-PG; krasavietz, isoform G; krasavietz; lethal (3) j9B6", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2922)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;12593794;18327897", "class_list": "", "function": "May be involved in memory formation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V2F9", "ec_number_list": [], "go_molecular_function": "GO:0043024 ribosomal small subunit binding;GO:0043022 ribosome binding;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0030175 filopodium;GO:0044295 axonal growth cone", "go_biological_process": "GO:0016199 axon midline choice point recognition;GO:0048149 behavioral response to ethanol;GO:0017148 negative regulation of translation;GO:0007616 long-term memory;GO:0051491 positive regulation of filopodium assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VNE2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VNK9-1", "uniprot_id": [ { "id": "OR83C_DROME", "url": "https://www.uniprot.org/uniprot/Q9VNK9", "type": "external" } ], "mass": 45487.0, "length": 397, "protein_name": "Putative odorant receptor 83c", "gene_name": "Or83c", "organism": "Fruit fly", "refseq_name": "odorant receptor 83c", "refseq_ac": [ { "id": "NP_524244", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524244", "type": "external" } ], "gene_names_uniprotkb": "Or83c; CG15581", "gene_names_refseq": "83D.1; 83c; CG15581; DOR116; Dmel\\CG15581; OR83C; Or83c", "protein_names_uniprotkb": "Putative odorant receptor 83c", "protein_names_refseq": "CG15581-PA; Or83c-PA; odorant receptor 83c", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15581)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;10943836;12537572", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VNK9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VNX1-1", "uniprot_id": [ { "id": "POLH_DROME", "url": "https://www.uniprot.org/uniprot/Q9VNX1", "type": "external" } ], "mass": 99026.0, "length": 885, "protein_name": "DNA polymerase eta", "gene_name": "PolH", "organism": "Fruit fly", "refseq_name": "DNA polymerase eta", "refseq_ac": [ { "id": "NP_649371", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649371", "type": "external" } ], "gene_names_uniprotkb": "PolH; CG7143; DNApol-eta; DNApolH; dPoleta; drad30A", "gene_names_refseq": "AAF51794; CG7143; DNA pol eta; DNA pol-eta; DNApol-eta; DNApoleta; Dmel\\CG7143; Dmpol eta; POLH; PolH; dPoleta; drad30A; pol eta; pol h", "protein_names_uniprotkb": "DNA polymerase eta; 2.7.7.7", "protein_names_refseq": "CG7143-PA; DNA polymerase eta; DNApol-eta; PolH-PA; polymerase eta", "tax_id": 7227, "disease": "xeroderma pigmentosum (Disease Ontology:DOID:0050427); female breast cancer (Disease Ontology:DOID:0050671); xeroderma pigmentosum variant type (Disease Ontology:DOID:0110847)", "pathway": " (dme:Dmel_CG7143); (R-DME-110320); (R-DME-5656169)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10731132;11297519;12537569;12537572;22532806;24553286", "class_list": "", "function": "DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:11297519). Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:11297519). Inserts one or 2 nucleotide(s) opposite the lesion (PubMed:11297519). During homologous recombination (HR) repair, has a overlapping role with the error-prone translesion polymerase PolZ1/DNApol-zeta to initiate repair synthesis that is completed by end joining or another polymerase that can bind and reinitiate synthesis (PubMed:22532806). Particularly important for the repair of UV-induced pyrimidine dimers and for hydroxyurea (HU)-induced DNA damage (PubMed:22532806, PubMed:24553286). Although inserts the correct base, may cause base transitions and transversions depending upon the context (By similarity). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue (By similarity). This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9GNC0;T2GGD2", "ec_number_list": [ { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0008270 zinc ion binding;GO:0003684 damaged DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0035861 site of double-strand break;GO:0005657 replication fork", "go_biological_process": "GO:0006302 double-strand break repair;GO:0009314 response to radiation;GO:0019985 translesion synthesis;GO:0042276 error-prone translesion synthesis;GO:0009650 UV protection", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VNX1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VP95-1", "uniprot_id": [ { "id": "SEMS_DROME", "url": "https://www.uniprot.org/uniprot/Q9VP95", "type": "external" } ], "mass": 30337.0, "length": 275, "protein_name": "Seminase", "gene_name": "Sems", "organism": "Fruit fly", "refseq_name": "seminase", "refseq_ac": [ { "id": "NP_649270", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649270", "type": "external" } ], "gene_names_uniprotkb": "Sems; CG10586", "gene_names_refseq": "CG10586; Dmel\\CG10586; SP168; Sems; sems", "protein_names_uniprotkb": "Seminase; 3.4.21.-", "protein_names_refseq": "CG10586-PA; Sems-PA; seminase", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10586)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;22253601;24514904", "class_list": "", "function": "Seminal fluid protease which is required for cleavage and probably also activation of the metalloprotease Semp1 (PubMed:22253601, PubMed:24514904). Also required for a number of female post-mating responses independent of Semp1 including egg laying and sperm usage (PubMed:22253601)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "C1C3F2;Q4QQ23;Q4QQ30", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0017171 serine hydrolase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007320 insemination;GO:0006508 proteolysis;GO:0031638 zymogen activation;GO:0045434 negative regulation of female receptivity, post-mating;GO:0046693 sperm storage", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VP95-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VPI2-1", "uniprot_id": [ { "id": "IR21A_DROME", "url": "https://www.uniprot.org/uniprot/Q9VPI2", "type": "external" } ], "mass": 95565.0, "length": 842, "protein_name": "Ionotropic receptor 21a", "gene_name": "Ir21a", "organism": "Fruit fly", "refseq_name": "ionotropic receptor 21a", "refseq_ac": [ { "id": "NP_001097043", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097043", "type": "external" } ], "gene_names_uniprotkb": "Ir21a; CG2657", "gene_names_refseq": "21a; CG2657; CT8983; DmelIR21a; Dmel\\CG2657; IR21a; Ir21a; ir21a", "protein_names_uniprotkb": "Ionotropic receptor 21a", "protein_names_refseq": "CG2657-PB; Ir21a-PB; ionotropic receptor 21a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2657); (R-DME-451307); (R-DME-451308); (R-DME-500657)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "10731132;12537572;19135896;27126188;27656904", "class_list": "", "function": "Integral part of a neural sensory system in the antenna that provides the neural basis for the response to environmental changes in temperature (thermosensation) (PubMed:27126188, PubMed:27656904). Together with Ir25a and Ir93a, mediates the response of the dorsal organ cool cells, a trio of cool-responsive neurons, to cooling and is required for cool avoidance behavior (PubMed:27126188, PubMed:27656904)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0008066 glutamate receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0050907 detection of chemical stimulus involved in sensory perception;GO:0035249 synaptic transmission, glutamatergic;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VPI2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VPK7-1", "uniprot_id": [ { "id": "PUS10_DROME", "url": "https://www.uniprot.org/uniprot/Q9VPK7", "type": "external" } ], "mass": 56763.0, "length": 500, "protein_name": "Putative tRNA pseudouridine synthase Pus10", "gene_name": "Pus10", "organism": "Fruit fly", "refseq_name": "pseudouridine synthase 10", "refseq_ac": [ { "id": "NP_608500", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608500", "type": "external" } ], "gene_names_uniprotkb": "Pus10; CG3709", "gene_names_refseq": "CG3709; Dmel\\CG3709; Pus10; anon-WO0257455.7", "protein_names_uniprotkb": "Putative tRNA pseudouridine synthase Pus10; 5.4.99.25; Coiled-coil domain-containing protein 139 homolog; Psi55 synthase; tRNA pseudouridine 55 synthase; tRNA pseudouridylate synthase; tRNA-uridine isomerase", "protein_names_refseq": "CG3709-PA; Pus10-PA; pseudouridine synthase 10", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3709)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.4.99.25", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.25", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0009982 pseudouridine synthase activity;GO:0106029 tRNA pseudouridine synthase activity;GO:0160148 tRNA pseudouridine(55) synthase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0031119 tRNA pseudouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VPK7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VPL3-1", "uniprot_id": [ { "id": "RM10_DROME", "url": "https://www.uniprot.org/uniprot/Q9VPL3", "type": "external" } ], "mass": 28337.0, "length": 248, "protein_name": "Large ribosomal subunit protein uL10m", "gene_name": "mRpL10", "organism": "Fruit fly", "refseq_name": "mitochondrial ribosomal protein L10", "refseq_ac": [ { "id": "NP_523440", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523440", "type": "external" } ], "gene_names_uniprotkb": "mRpL10; CG11488", "gene_names_refseq": "CG11488; Dmel\\CG11488; L10; RpL10; mRpL10", "protein_names_uniprotkb": "Large ribosomal subunit protein uL10m; 39S ribosomal protein L10, mitochondrial; L10mt; MRP-L10", "protein_names_refseq": "CG11488-PA; mRpL10-PA; mitochondrial ribosomal protein L10", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11488); (R-DME-5389840); (R-DME-5419276); (R-DME-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VPL3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VPT7-1", "uniprot_id": [ { "id": "PGAP2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VPT7", "type": "external" } ], "mass": 29669.0, "length": 255, "protein_name": "Post-GPI attachment to proteins factor 2", "gene_name": "PGAP2", "organism": "Fruit fly", "refseq_name": "Post-GPI attachment to proteins 2", "refseq_ac": [ { "id": "NP_608548", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608548", "type": "external" } ], "gene_names_uniprotkb": "PGAP2; CG3876", "gene_names_refseq": "CG3876; Dmel\\CG3876; PGAP2", "protein_names_uniprotkb": "Post-GPI attachment to proteins factor 2", "protein_names_refseq": "CG3876-PA; PGAP2-PA; Post-GPI attachment to proteins 2", "tax_id": 7227, "disease": "hyperphosphatasia with impaired intellectual development syndrome 3 (Disease Ontology:DOID:0070435)", "pathway": " (dme:Dmel_CG3876)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VPT7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VPY8-1", "uniprot_id": [ { "id": "TGT_DROME", "url": "https://www.uniprot.org/uniprot/Q9VPY8", "type": "external" } ], "mass": 47751.0, "length": 427, "protein_name": "Queuine tRNA-ribosyltransferase catalytic subunit", "gene_name": "Tgt", "organism": "Fruit fly", "refseq_name": "tRNA-guanine transglycosylase", "refseq_ac": [ { "id": "NP_608585", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608585", "type": "external" } ], "gene_names_uniprotkb": "Tgt; CG4947", "gene_names_refseq": "CG4947; Dmel\\CG4947; TGT; Tgt; tgt", "protein_names_uniprotkb": "Queuine tRNA-ribosyltransferase catalytic subunit; 2.4.2.64; Guanine insertion enzyme; tRNA-guanine transglycosylase", "protein_names_refseq": "CG4947-PA; Tgt-PA; tRNA-guanine transglycosylase", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4947)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.2.64", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.64", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008479 tRNA-guanosine(34) queuine transglycosylase activity", "go_cellular_component": "GO:0032473 cytoplasmic side of mitochondrial outer membrane;GO:0120507 tRNA-guanine transglycosylase complex", "go_biological_process": "GO:0002099 tRNA wobble guanine modification", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VPY8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VQ26-1", "uniprot_id": [ { "id": "RB3GP_DROME", "url": "https://www.uniprot.org/uniprot/Q9VQ26", "type": "external" } ], "mass": 104431.0, "length": 916, "protein_name": "Rab3 GTPase-activating protein catalytic subunit", "gene_name": "Rab3GAP1", "organism": "Fruit fly", "refseq_name": "RAB3 GTPase activating protein subunit 1", "refseq_ac": [ { "id": "NP_608608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608608", "type": "external" } ], "gene_names_uniprotkb": "Rab3GAP1; CG31935", "gene_names_refseq": "CG10870; CG31935; CG7373; Dmel\\CG31935; Rab3GAP1", "protein_names_uniprotkb": "Rab3 GTPase-activating protein catalytic subunit", "protein_names_refseq": "CG31935-PA; RAB3 GTPase activating protein catalytic subunit 1; RAB3 GTPase activating protein subunit 1; Rab3GAP1-PA", "tax_id": 7227, "disease": "Warburg micro syndrome (Disease Ontology:DOID:0060237); Warburg micro syndrome 1 (Disease Ontology:DOID:0110716)", "pathway": " (dme:Dmel_CG31935); (R-DME-6811436); (R-DME-8876198)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10731132;12537572;18327897;21338884;32248620", "class_list": "", "function": "Catalytic subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of Rab3-GAP and Rab3GAP1, which has both GTPase-activating protein (GAP) activity towards Rab3, and guanine nucleotide exchange factor (GEF) activity towards Rab18 (Probable). As part of the Rab3GAP complex, required for the rapid induction and sustained expression of synaptic homeostasis at the neuromuscular junction (NMJ) (Probable). Also participates in the regulation of autophagy in tissues such as larval fat cells and adult muscles (Probable). The Rab3GAP complex, acts as a GAP for Rab3 by converting active Rab3-GTP to the inactive form Rab3-GDP (By similarity). At the neuromuscular junction (NMJ), forms a presynaptic signaling mechanism with Rab3 that regulates progression of synaptic homeostasis at a late stage of vesicle release (Probable). Within this mechanism Rab3-GTP acts, directly or indirectly, to inhibit the progression of synaptic homeostasis, and Rab3-GAP functions to inactivate this action of Rab3-GTP (Probable). The Rab3GAP complex, acts as a GEF for Rab18 by promoting the conversion of inactive Rab18-GDP to the active form Rab18-GTP (By similarity). Regulates autophagy as part of a Rab3GAP-Rab18 module (PubMed:32248620). Once Rab18 is activated by the GEF Rab3GAP complex, the Rab3GAP-Rab18 module localizes to autophagosomes, and regulates autolysosome formation and maturation together with the Rab18 interacting effector, the PI3K/Vps34 Complex I (PubMed:32248620)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0098794 postsynapse;GO:0032991 protein-containing complex;GO:0071782 endoplasmic reticulum tubular network", "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0097051 establishment of protein localization to endoplasmic reticulum membrane;GO:0060079 excitatory postsynaptic potential;GO:0016236 macroautophagy;GO:0034389 lipid droplet organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VQ26-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VQ66-1", "uniprot_id": [ { "id": "NPLP4_DROME", "url": "https://www.uniprot.org/uniprot/Q9VQ66", "type": "external" } ], "mass": 6798.0, "length": 64, "protein_name": "Neuropeptide-like 4", "gene_name": "Nplp4", "organism": "Fruit fly", "refseq_name": "Neuropeptide-like precursor 4, isoform B", "refseq_ac": [ { "id": "NP_001259893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259893", "type": "external" } ], "gene_names_uniprotkb": "Nplp4; CG15361", "gene_names_refseq": "CG15361; Dmel\\CG15361; NPLP4; Nplp4; YSY", "protein_names_uniprotkb": "Neuropeptide-like 4; YSY peptide", "protein_names_refseq": "CG15361-PB; Neuropeptide-like precursor 4, isoform B; Nplp4-PB; YSY peptide; neuropeptide-like precursor 4", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15361)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12171930;12537572;14690519", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VQ66-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VQ91-1", "uniprot_id": [ { "id": "TDRKH_DROME", "url": "https://www.uniprot.org/uniprot/Q9VQ91", "type": "external" } ], "mass": 63823.0, "length": 576, "protein_name": "Tudor and KH domain-containing protein homolog", "gene_name": "papi", "organism": "Fruit fly", "refseq_name": "papi, isoform C", "refseq_ac": [ { "id": "NP_608657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608657", "type": "external" } ], "gene_names_uniprotkb": "papi; CG7082; Tdrd2", "gene_names_refseq": "CG7082; Dmel\\CG7082; PAPI; Papi; cg7082; papi", "protein_names_uniprotkb": "Tudor and KH domain-containing protein homolog; Partner of PIWIs protein", "protein_names_refseq": "CG7082-PC; papi, isoform C; papi-PC; partner of PIWIs", "tax_id": 7227, "disease": "azoospermia (Disease Ontology:DOID:14227)", "pathway": " (dme:Dmel_CG7082)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;21447556;29531043", "class_list": "", "function": "Involved in the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons which is essential for germline integrity (PubMed:21447556, PubMed:29531043). Likely to act by recruiting Piwi proteins such as AGO3 and piwi to the piRNA biogenesis machinery in the nuage (PubMed:21447556, PubMed:29531043). Required for the final steps of primary piRNA biogenesis by participating in the 3' end-trimming of piwi-bound intermediates into mature piRNAs (PubMed:29531043)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0032991 protein-containing complex;GO:0043186 P granule", "go_biological_process": "GO:0030719 P granule organization;GO:0007283 spermatogenesis;GO:0034587 piRNA processing;GO:0010526 transposable element silencing;GO:0140990 primary piRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VQ91-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VQF9-1", "uniprot_id": [ { "id": "SNAPN_DROME", "url": "https://www.uniprot.org/uniprot/Q9VQF9", "type": "external" } ], "mass": 15056.0, "length": 134, "protein_name": "SNAPIN protein homolog", "gene_name": "Snapin", "organism": "Fruit fly", "refseq_name": "SNAP associated protein", "refseq_ac": [ { "id": "NP_722835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_722835", "type": "external" } ], "gene_names_uniprotkb": "Snapin; CG9958", "gene_names_refseq": "CG32951; CG9958; Dmel\\CG9958; Dromel_CG9960_CG9958_FBtr007773_snapin_uORF; NP_722835; SNAPIN; Snapin; snapin", "protein_names_uniprotkb": "SNAPIN protein homolog; BLOC-1 subunit 7; Biogenesis of lysosome-related organelles complex 1 subunit 7", "protein_names_refseq": "CG9958-PA; CPuORF of FBgn0031454; SNAP associated protein; Snapin-PA; snapin ortholog; snapin", "tax_id": 7227, "disease": "Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753)", "pathway": " (dme:Dmel_CG9958); (R-DME-432722)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537572;20015953", "class_list": "", "function": "Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis (PubMed:20015953). May participate in the coupling of lysosomes to microtubule plus-end-directed kinesin motor (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000149 SNARE binding", "go_cellular_component": "GO:0005829 cytosol;GO:0030141 secretory granule;GO:0008021 synaptic vesicle;GO:0098574 cytoplasmic side of lysosomal membrane;GO:0031083 BLOC-1 complex", "go_biological_process": "GO:0008057 eye pigment granule organization;GO:0006886 intracellular protein transport;GO:0007040 lysosome organization;GO:0008333 endosome to lysosome transport;GO:0042592 homeostatic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VQF9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VQS7-1", "uniprot_id": [ { "id": "SOB_DROME", "url": "https://www.uniprot.org/uniprot/Q9VQS7", "type": "external" } ], "mass": 58455.0, "length": 578, "protein_name": "Protein sister of odd and bowel", "gene_name": "sob", "organism": "Fruit fly", "refseq_name": "sister of odd and bowl", "refseq_ac": [ { "id": "NP_476882", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476882", "type": "external" } ], "gene_names_uniprotkb": "sob; CG3242", "gene_names_refseq": "CG3242; Dmel\\CG3242; SOB; Sob; org1; sob", "protein_names_uniprotkb": "Protein sister of odd and bowel", "protein_names_refseq": "CG3242-PA; odd skipped-related 1; sister of odd and bowl; sister-of-odd-skipped; sob-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3242)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537572;14568103;14597202;8878683", "class_list": "", "function": "Pair-rule protein that determines both the size and polarity of even-numbered as well as odd-numbered parasegments during embryogenesis. DNA-binding transcription factor that acts primarily as a transcriptional repressor but can also function as a transcriptional activator, depending on the stage of development and spatial restrictions (By similarity). May function redundantly with odd and drm in leg joint formation during the larval stages, acting downstream of Notch activation., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24571", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0048619 embryonic hindgut morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VQS7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VQY9-1", "uniprot_id": [ { "id": "PSF2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VQY9", "type": "external" } ], "mass": 23114.0, "length": 203, "protein_name": "Probable DNA replication complex GINS protein PSF2", "gene_name": "Psf2", "organism": "Fruit fly", "refseq_name": "partner of Sld five 2, isoform C", "refseq_ac": [ { "id": "NP_001260022", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260022", "type": "external" } ], "gene_names_uniprotkb": "Psf2; CG18013", "gene_names_refseq": "CG18013; Dmel\\CG18013; PSF2; Psf2; P{lacW}l(2)SH0805[SH0805]; l(2)SH0805; l(2)SH2 0805", "protein_names_uniprotkb": "Probable DNA replication complex GINS protein PSF2; GINS complex subunit 2", "protein_names_refseq": "CG18013-PC; Psf2-PC; lethal (2) SH0805; partner of Sld five 2, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18013); (R-DME-176974)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "The GINS complex plays an essential role in the initiation of DNA replication., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "M9PB28;Q8SYY9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0000811 GINS complex;GO:0071162 CMG complex", "go_biological_process": "GO:0006271 DNA strand elongation involved in DNA replication;GO:0006260 DNA replication;GO:0030261 chromosome condensation;GO:0006270 DNA replication initiation;GO:0032784 regulation of DNA-templated transcription elongation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VQY9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VR50-1", "uniprot_id": [ { "id": "S35E1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VR50", "type": "external" } ], "mass": 41618.0, "length": 373, "protein_name": "Solute carrier family 35 member E1 homolog", "gene_name": "Slc35e1; lincRNA.1043", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform D", "refseq_ac": [ { "id": "NP_001285522", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285522", "type": "external" } ], "gene_names_uniprotkb": "Slc35e1; lincRNA.1043; CG14621; Dmel\\CG14621; Dmel_CG14621; Slc35e1; lincRNA.1043", "gene_names_refseq": "CG14621; Dmel\\CG14621; Slc35e1; lincRNA.1043", "protein_names_uniprotkb": "Solute carrier family 35 member E1 homolog", "protein_names_refseq": "CG14621-PD; uncharacterized protein, isoform D", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14621)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Putative transporter., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015297 antiporter activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VR50-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VRC9-1", "uniprot_id": [ { "id": "NPC1B_DROME", "url": "https://www.uniprot.org/uniprot/Q9VRC9", "type": "external" } ], "mass": 139556.0, "length": 1254, "protein_name": "NPC intracellular cholesterol transporter 1 homolog 1b", "gene_name": "Npc1b", "organism": "Fruit fly", "refseq_name": "Niemann-Pick type C-1b", "refseq_ac": [ { "id": "NP_608417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608417", "type": "external" } ], "gene_names_uniprotkb": "Npc1b; CG12092", "gene_names_refseq": "151; 4; 7; AF2/19; CG12092; Dmel\\CG12092; NPC1b; Npc1b; Q256; R-9-28; R9-28; dncp1b; dnpc1b; l(1)19Ec; l(1)2-3; l(1)R-9-28; l151; l152; lN5; lt2-14a; npc1b", "protein_names_uniprotkb": "NPC intracellular cholesterol transporter 1 homolog 1b; Niemann-Pick type protein homolog 1b", "protein_names_refseq": "CG12092-PA; NPC1b; Niemann-Pick type C-1b; Niemann-Pick; Npc1b-PA; lethal (1) 19Ec; section 4; section 7", "tax_id": 7227, "disease": "Niemann-Pick disease type C1 (Disease Ontology:DOID:0070113); Niemann-Pick disease (Disease Ontology:DOID:14504)", "pathway": " (dme:Dmel_CG12092); (R-DME-8963678)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537572;17339027", "class_list": "", "function": "Important for cholesterol absorption at the midgut epithelium. Acts only in the early steps of sterol absorption, prior to Npc1a-dependent intracellular sterol trafficking., [UniProtKB, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0015485 cholesterol binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0007417 central nervous system development;GO:0030299 intestinal cholesterol absorption;GO:0042632 cholesterol homeostasis;GO:0007422 peripheral nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VRC9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VRK8-1", "uniprot_id": [ { "id": "PLBL_DROME", "url": "https://www.uniprot.org/uniprot/Q9VRK8", "type": "external" } ], "mass": 74874.0, "length": 658, "protein_name": "Putative phospholipase B-like lamina ancestor", "gene_name": "lama", "organism": "Fruit fly", "refseq_name": "lamina ancestor, isoform D", "refseq_ac": [ { "id": "NP_001261440", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261440", "type": "external" } ], "gene_names_uniprotkb": "lama; CG10645", "gene_names_refseq": "CG10645; Dmel\\CG10645; lama", "protein_names_uniprotkb": "Putative phospholipase B-like lamina ancestor; 3.1.1.-", "protein_names_refseq": "CG10645-PD; lama-PD; lamina ancestor, isoform D", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10645)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;16077094;8892229", "class_list": "", "function": "Putative phospholipase (By similarity). Involved in the regulation of cellular plasticity in imaginal disks., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A4V1I2;Q8IH16;Q94898", "ec_number_list": [], "go_molecular_function": "GO:0004620 phospholipase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0009395 phospholipid catabolic process;GO:0007444 imaginal disc development;GO:0046843 dorsal appendage formation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VRK8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VRN2-1", "uniprot_id": [ { "id": "MTH2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VRN2", "type": "external" } ], "mass": 60350.0, "length": 518, "protein_name": "Probable G protein-coupled receptor Mth-like 2", "gene_name": "mthl2", "organism": "Fruit fly", "refseq_name": "methuselah-like 2", "refseq_ac": [ { "id": "NP_788462", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788462", "type": "external" } ], "gene_names_uniprotkb": "mthl2; CG17795", "gene_names_refseq": "CG17795; Dmel\\CG17795; Mth-2; Mthl2; anon-WO0170980.28; anon-WO0170980.29; mthl2", "protein_names_uniprotkb": "Probable G protein-coupled receptor Mth-like 2; Protein methuselah-like 2", "protein_names_refseq": "CG17795-PB; methuselah-like 2; mth-like 2; mthl2-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17795)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;10908591;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B5RIK3;Q8SWY8", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008528 G protein-coupled peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0042594 response to starvation;GO:0008340 determination of adult lifespan", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VRN2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VRP5-3", "uniprot_id": [ { "id": "UBP36_DROME", "url": "https://www.uniprot.org/uniprot/Q9VRP5", "type": "external" } ], "mass": 114088.0, "length": 1038, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 36", "gene_name": "scny", "organism": "Fruit fly", "refseq_name": "scrawny, isoform G", "refseq_ac": [ { "id": "NP_001246639", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246639", "type": "external" } ], "gene_names_uniprotkb": "scny; CG5505; Usp36", "gene_names_refseq": "2331; CG5505; Dmel\\CG5505; Q9VRP5; SP36/Scny; Scny; USP36; Usp36; anon-WO0118547.247; dUSP36; dUsp36; et; l(3)02331; mule; scny; usp36", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 36; 3.4.19.12; Deubiquitinating enzyme 36; Protein scrawny; Ubiquitin thioesterase 36; Ubiquitin-specific-processing protease 36", "protein_names_refseq": "CG5505-PG; emperor's thumb; lethal (3) 02331; mule; scny-PG; scrawny, isoform G; scrawny; ubiquitin C-terminal hydrolase 36; ubiquitin specific protease 36; ubiquitin-specific protease 36", "tax_id": 7227, "disease": "congenital heart disease (Disease Ontology:DOID:1682); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (dme:Dmel_CG5505); (R-DME-5689880); (R-DME-9648002)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10731132;12537569;12537572;18327897;19039105;19837371;22622177;25027767", "class_list": "", "function": "Hydrolase that deubiquitinates polyubiquitinated target proteins including imd (PubMed:19039105, PubMed:19837371). Required for preventing the constitutive activation of the imd/NF-kappa-B (Imd) signaling cascade under unchalleneged conditions (PubMed:19837371, PubMed:25027767). Deubiquitinates imd linked 'Lys-63' chains which leads its proteasomal degradation and consequently down-regulation of the Imd signaling cascade (PubMed:19837371). Removal of the activating 'Lys-63'-linked chains is likely to enable their replacement with 'Lys-48'-linked chains which act as 'tags' the for proteasomal degradation of imd (PubMed:19837371). Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells (PubMed:19039105). May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4me3) (PubMed:19039105). Controls selective autophagy activation by ubiquitinated proteins (PubMed:22622177)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "M9NE30;Q7YTX7;Q86NM9;Q8IQ57;Q8IQ58;Q8IQ59;Q8IQ60;Q960Q4", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.26.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.26.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity;GO:0061578 K63-linked deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability;GO:0042981 regulation of apoptotic process;GO:0016242 negative regulation of macroautophagy", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9VRP5-3", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VS38-1", "uniprot_id": [ { "id": "MED4_DROME", "url": "https://www.uniprot.org/uniprot/Q9VS38", "type": "external" } ], "mass": 28313.0, "length": 258, "protein_name": "Mediator of RNA polymerase II transcription subunit 4", "gene_name": "MED4", "organism": "Fruit fly", "refseq_name": "mediator complex subunit 4", "refseq_ac": [ { "id": "NP_648094", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648094", "type": "external" } ], "gene_names_uniprotkb": "MED4; CG8609; Trap36", "gene_names_refseq": "CG8609; Dmel\\CG8609; MED4; Med4/TRAP36; Med4; Trap36; dTRAP36; dp34; med4; p34", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 4; Mediator complex subunit 4; dp34", "protein_names_refseq": "CG8609-PA; MED4-PA; mediator complex subunit 4; mediator", "tax_id": 7227, "disease": "cervical cancer (Disease Ontology:DOID:4362)", "pathway": " (dme:Dmel_CG8609); (R-DME-9841922)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10731132;11259581;12021283;12537569;12537572;15477388;16751183", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA, MtnB and MtnD genes., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9VS38-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VSF2-1", "uniprot_id": [ { "id": "MED24_DROME", "url": "https://www.uniprot.org/uniprot/Q9VSF2", "type": "external" } ], "mass": 111743.0, "length": 993, "protein_name": "Mediator of RNA polymerase II transcription subunit 24", "gene_name": "MED24", "organism": "Fruit fly", "refseq_name": "mediator complex subunit 24", "refseq_ac": [ { "id": "NP_648185", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648185", "type": "external" } ], "gene_names_uniprotkb": "MED24; CG7999; Trap100", "gene_names_refseq": "CG7999; Dmel\\CG7999; MED24; Med24; Trap100; dTRAP100; l(3)psg5; med24; psg5", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 24; Mediator complex subunit 24; dMED24; dTRAP100", "protein_names_refseq": "CG7999-PA; MED24-PA; mediator complex subunit 24; mediator", "tax_id": 7227, "disease": "Hirschsprung's disease (Disease Ontology:DOID:10487); intestinal disease (Disease Ontology:DOID:5295); neuropathy (Disease Ontology:DOID:870)", "pathway": " (dme:Dmel_CG7999); (R-DME-9841922)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10731132;12021283;12537569;12537572;16751183;18327897", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA, MtnB and MtnD genes., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MQZ3;Q9GYW5", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016592 mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0043067 regulation of programmed cell death", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VSF2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VSL3-1", "uniprot_id": [ { "id": "SEPIA_DROME", "url": "https://www.uniprot.org/uniprot/Q9VSL3", "type": "external" } ], "mass": 28413.0, "length": 243, "protein_name": "Pyrimidodiazepine synthase", "gene_name": "se", "organism": "Fruit fly", "refseq_name": "sepia", "refseq_ac": [ { "id": "NP_648235", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648235", "type": "external" } ], "gene_names_uniprotkb": "se; CG6781", "gene_names_refseq": "CG6781; DmGSTO4; Dmel\\CG6781; GSTO1; GSTO4; Sepia; cg6781; dmgsto1; se", "protein_names_uniprotkb": "Pyrimidodiazepine synthase; 1.5.4.1; Protein sepia", "protein_names_refseq": "CG6781-PA; se-PA; sepia", "tax_id": 7227, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); colon adenocarcinoma (Disease Ontology:DOID:234); asthma (Disease Ontology:DOID:2841)", "pathway": " (dme:Dmel_CG6781); (R-DME-156581); (R-DME-156590); (R-DME-196836)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;16712527;19608790;6438092", "class_list": "", "function": "Mediates the conversion of 2-amino-4-oxo-6-pyruvoyl-5,6,7,8-tetrahydropteridine (6-PTP; also named 6-pyruvoyltetrahydropterin) to 2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido(4,5-b)[1,4]diazepin-4-one (pyrimidodiazepine or PDA), a key intermediate in red eye pigment drosopterin biosynthesis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D1KS67;D1KS72", "ec_number_list": [ { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" }, { "id": "1.5.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.4.1", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0042803 protein homodimerization activity;GO:0045174 glutathione dehydrogenase (ascorbate) activity;GO:0004734 pyrimidodiazepine synthase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006726 eye pigment biosynthetic process;GO:0006749 glutathione metabolic process;GO:0006728 pteridine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VSL3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VSZ6-1", "uniprot_id": [ { "id": "QTRT2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VSZ6", "type": "external" } ], "mass": 46585.0, "length": 418, "protein_name": "Queuine tRNA-ribosyltransferase accessory subunit 2", "gene_name": "CG3434", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_648320", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648320", "type": "external" } ], "gene_names_uniprotkb": "CG3434", "gene_names_refseq": "CG3434; Dmel\\CG3434", "protein_names_uniprotkb": "Queuine tRNA-ribosyltransferase accessory subunit 2; Queuine tRNA-ribosyltransferase domain-containing protein 1", "protein_names_refseq": "CG3434-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3434)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008479 tRNA-guanosine(34) queuine transglycosylase activity", "go_cellular_component": "GO:0032473 cytoplasmic side of mitochondrial outer membrane;GO:0120507 tRNA-guanine transglycosylase complex", "go_biological_process": "GO:0002099 tRNA wobble guanine modification", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VSZ6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VT90-1", "uniprot_id": [ { "id": "OR67C_DROME", "url": "https://www.uniprot.org/uniprot/Q9VT90", "type": "external" } ], "mass": 46951.0, "length": 404, "protein_name": "Odorant receptor 67c", "gene_name": "Or67c", "organism": "Fruit fly", "refseq_name": "odorant receptor 67c", "refseq_ac": [ { "id": "NP_524018", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524018", "type": "external" } ], "gene_names_uniprotkb": "Or67c; CG14156", "gene_names_refseq": "67D.1; 67c; CG14156; DOR77; DmOR67C; Dmel\\CG14156; OR67c; Or67c", "protein_names_uniprotkb": "Odorant receptor 67c", "protein_names_refseq": "CG14156-PA; Or67c-PA; odorant receptor 67c", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14156)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;10943836;12537572;16615896", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VT90-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VTE2-1", "uniprot_id": [ { "id": "SUUR_DROME", "url": "https://www.uniprot.org/uniprot/Q9VTE2", "type": "external" } ], "mass": 107625.0, "length": 962, "protein_name": "Protein suppressor of underreplication", "gene_name": "SuUR", "organism": "Fruit fly", "refseq_name": "suppressor of Under-Replication", "refseq_ac": [ { "id": "NP_524835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524835", "type": "external" } ], "gene_names_uniprotkb": "SuUR; CG7869; Su(UR)ES", "gene_names_refseq": "CG7869; Dmel\\CG7869; Dromel_CG7869_FBtr0076203_suur_mORF; SU(UR); SUUR; Su(UR)ES; Su(UR); SuUR; su(UR)ES", "protein_names_uniprotkb": "Protein suppressor of underreplication", "protein_names_refseq": "CG7869-PA; SuUR-PA; suppressor of Under- replication; suppressor of Under-Replication; suppressor of underreplication protein; suppressor of underreplication", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7869)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10731132;11901119;12456726;12537572;12644953;18327897;30277458", "class_list": "", "function": "Required for underreplication of DNA, which is found in many late replicating euchromatic regions of salivary gland polytene chromosomes (PubMed:11901119, PubMed:12456726, PubMed:30277458). Functions by promoting the localization and retention of Rif1 to active DNA replication forks where Rif1 inhibits replication fork progression (PubMed:30277458). Controls chromatin organization in polytene chromosomes (PubMed:12456726)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9N6U5", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0000792 heterochromatin;GO:0005721 pericentric heterochromatin;GO:0005725 intercalary heterochromatin", "go_biological_process": "GO:0032877 positive regulation of DNA endoreduplication;GO:2000104 negative regulation of DNA-templated DNA replication;GO:0006260 DNA replication;GO:0006325 chromatin organization;GO:0045185 maintenance of protein location", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9VTE2-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VTH4-1", "uniprot_id": [ { "id": "SCLLA_DROME", "url": "https://www.uniprot.org/uniprot/Q9VTH4", "type": "external" } ], "mass": 30762.0, "length": 280, "protein_name": "Protein scylla", "gene_name": "scyl", "organism": "Fruit fly", "refseq_name": "scylla, isoform A", "refseq_ac": [ { "id": "NP_648456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648456", "type": "external" } ], "gene_names_uniprotkb": "scyl; CG7590", "gene_names_refseq": "7590; CG7590; Dmel\\CG7590; Scylla; Scyl; anon-WO0118547.215; scyl; scy", "protein_names_uniprotkb": "Protein scylla; Protein regulated in development and DNA damage response 2; REDD-2", "protein_names_refseq": "CG7590-PA; scyl-PA; scylla, isoform A; scylla", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7590); (R-DME-5628897)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10731132;12453409;12537569;12537572;15545626;15632201;16423342", "class_list": "", "function": "Inhibits cell growth by regulating the Tor pathway upstream of the Tsc1-Tsc2 complex and downstream of Akt1. Acts as a cell death activator during head development., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EQR6;Q5U1B7;Q8SY44;Q9NHN4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0006915 apoptotic process;GO:0009968 negative regulation of signal transduction;GO:0032006 regulation of TOR signaling;GO:0007618 mating", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9VTH4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VTL1-1", "uniprot_id": [ { "id": "PCID2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VTL1", "type": "external" } ], "mass": 45180.0, "length": 395, "protein_name": "PCI domain-containing protein 2 homolog", "gene_name": "PCID2", "organism": "Fruit fly", "refseq_name": "PCI domain-containing protein 2", "refseq_ac": [ { "id": "NP_648486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648486", "type": "external" } ], "gene_names_uniprotkb": "PCID2; CG7351", "gene_names_refseq": "CG7351; Dmel\\CG7351; PCID2; dmPCID2", "protein_names_uniprotkb": "PCI domain-containing protein 2 homolog; CSN12-like protein", "protein_names_refseq": "CG7351-PA; PCI domain-containing protein 2; PCID2-PA; drosophila melanogaster PCID2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7351)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10731132;12537569;12537572;18086857;27016737;28554770;33602059", "class_list": "", "function": "Required for the export of nuclear mRNAs and involved in mRNA trafficking in the cytoplasm (PubMed:27016737, PubMed:28554770, PubMed:33602059). Component of the nuclear pore complex (NPC)-associated TREX-2/AMEX complex (anchoring and mRNA export complex) which functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket), thereby enabling the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:27016737, PubMed:28554770, PubMed:33602059). Within the complex, specifically promotes the association of factors involved in regulating nuclear mRNA export, such as Moe, sbr/NXF1 and the ORC complex, to the mRNPs particles (PubMed:27016737, PubMed:28554770, PubMed:33602059). In the cytoplasm, functions independently of its role in the TREX-2/AMEX complex, to promote cytoplasmic mRNA trafficking together with nudC (PubMed:33602059). Associates with translationally active polysomes (PubMed:18086857)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0019904 protein domain specific binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0031965 nuclear membrane;GO:0070390 transcription export complex 2", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0006406 mRNA export from nucleus;GO:0006417 regulation of translation;GO:0015031 protein transport;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9VTL1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VTN3-1", "uniprot_id": [ { "id": "TIM13_DROME", "url": "https://www.uniprot.org/uniprot/Q9VTN3", "type": "external" } ], "mass": 10693.0, "length": 92, "protein_name": "Mitochondrial import inner membrane translocase subunit Tim13", "gene_name": "Tim13", "organism": "Fruit fly", "refseq_name": "Tim13", "refseq_ac": [ { "id": "NP_648505", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648505", "type": "external" } ], "gene_names_uniprotkb": "Tim13; CG11611", "gene_names_refseq": "CG11611; Dmel\\CG11611; Tim13", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit Tim13", "protein_names_refseq": "CG11611-PA; Tim13-PA; Tim13", "tax_id": 7227, "disease": "deafness-dystonia-optic neuronopathy syndrome (Disease Ontology:DOID:0050757)", "pathway": " (dme:Dmel_CG11611)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The Tim8-Tim13 complex mediates the import of some proteins while the predominant Tim9-Tim10 70 kDa complex mediates the import of much more proteins (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B3DMW4", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0140318 protein transporter activity", "go_cellular_component": "GO:0042719 mitochondrial intermembrane space chaperone complex;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0015031 protein transport;GO:0045039 protein insertion into mitochondrial inner membrane", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VTN3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VTU0-1", "uniprot_id": [ { "id": "KRI1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VTU0", "type": "external" } ], "mass": 98722.0, "length": 855, "protein_name": "Protein KRI1 homolog", "gene_name": "CG5645", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_648550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648550", "type": "external" } ], "gene_names_uniprotkb": "CG5645", "gene_names_refseq": "CG5645; Dmel\\CG5645", "protein_names_uniprotkb": "Protein KRI1 homolog", "protein_names_refseq": "CG5645-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5645)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;17372656;18327897;40245499", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0030686 90S preribosome", "go_biological_process": "GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9VTU0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VTW2-1", "uniprot_id": [ { "id": "INP5E_DROME", "url": "https://www.uniprot.org/uniprot/Q9VTW2", "type": "external" } ], "mass": 82590.0, "length": 747, "protein_name": "Inositol polyphosphate 5-phosphatase E", "gene_name": "INPP5E", "organism": "Fruit fly", "refseq_name": "inositol polyphosphate 5-phosphatase E, isoform B", "refseq_ac": [ { "id": "NP_001261753", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261753", "type": "external" } ], "gene_names_uniprotkb": "INPP5E; CG10426", "gene_names_refseq": "CG10426; Dmel\\CG10426; INPP5E; INPPE5; IPP; Inpp5e; dInpp5e", "protein_names_uniprotkb": "Inositol polyphosphate 5-phosphatase E; 3.1.3.36; Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; Phosphatidylinositol polyphosphate 5-phosphatase type IV", "protein_names_refseq": "CG10426-PB; INPP5E-PB; inositol polyphosphate 5-phosphatase E, isoform B; pharbin-like", "tax_id": 7227, "disease": "Joubert syndrome (Disease Ontology:DOID:0050777); Joubert syndrome 1 (Disease Ontology:DOID:0110980); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG10426)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;26723017", "class_list": "", "function": "Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2, and phosphatidylinositol 4,5-bisphosphate (PtdIns 4,5-P2) to phosphatidylinositol 4-phosphate (PI-4-P). By controlling the phosphoinositide composition of the cilia membrane of auditory receptor neurons, regulates the cilia localization of ktub and consequently the transient receptor potential channels iav and nompC., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0097546 ciliary base", "go_biological_process": "GO:0007605 sensory perception of sound;GO:0061512 protein localization to cilium;GO:0046856 phosphatidylinositol dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VTW2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VTY6-1", "uniprot_id": [ { "id": "UBE2C_DROME", "url": "https://www.uniprot.org/uniprot/Q9VTY6", "type": "external" } ], "mass": 19832.0, "length": 178, "protein_name": "Ubiquitin-conjugating enzyme E2 C", "gene_name": "vih", "organism": "Fruit fly", "refseq_name": "vihar", "refseq_ac": [ { "id": "NP_648582", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648582", "type": "external" } ], "gene_names_uniprotkb": "vih; CG10682; Ubch10", "gene_names_refseq": "1105/01; CG10682; Dmel\\CG10682; UbcH10; anon-WO0172774.54; anon-WO0172774.55; anon-WO0172774.56; l(3)S110501; vih", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 C; (E3-independent) E2 ubiquitin-conjugating enzyme C; 2.3.2.23; 2.3.2.24; E2 ubiquitin-conjugating enzyme C; Ubiquitin carrier protein C; Ubiquitin carrier protein vihar; Ubiquitin-protein ligase C", "protein_names_refseq": "CG10682-PA; lethal (3) S110501; vih-PA; vihar", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10682); (R-DME-141430); (R-DME-174048); (R-DME-174084); (R-DME-174154); (R-DME-174178); (R-DME-174184); (R-DME-176407); (R-DME-176408); (R-DME-176409); (R-DME-176412); (R-DME-179409); (R-DME-2467813); (R-DME-2559582); (R-DME-68867); (R-DME-69017); (R-DME-8866652); (R-DME-983168)", "pathway_count": 18, "publication_count": 4, "publication_id_list": "10731132;12537572;15458643;19822757", "class_list": "", "function": "Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.1.1.356", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.356", "type": "external" }, { "id": "2.1.1.367", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367", "type": "external" }, { "id": "2.1.1.371", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.371", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.369", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.369", "type": "external" }, { "id": "2.1.1.368", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.368", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "5.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.5", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0031371 ubiquitin conjugating enzyme complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0010458 exit from mitosis;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0045732 positive regulation of protein catabolic process;GO:0045842 positive regulation of mitotic metaphase/anaphase transition;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VTY6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VTZ6-1", "uniprot_id": [ { "id": "PMM_DROME", "url": "https://www.uniprot.org/uniprot/Q9VTZ6", "type": "external" } ], "mass": 29667.0, "length": 254, "protein_name": "Phosphomannomutase", "gene_name": "Pmm2", "organism": "Fruit fly", "refseq_name": "phosphomannomutase type 2", "refseq_ac": [ { "id": "NP_648589", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648589", "type": "external" } ], "gene_names_uniprotkb": "Pmm2; CG10688", "gene_names_refseq": "33589256; CG10688; Dmel\\CG10688; Pmm2; pmm2", "protein_names_uniprotkb": "Phosphomannomutase; 5.4.2.8; Phosphomannomutase 2; Phosphomannomutase type 2", "protein_names_refseq": "CG10688-PA; Pmm2-PA; phosphomannomutase type 2; phosphomannomutase-2", "tax_id": 7227, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); congenital disorder of glycosylation Ia (Disease Ontology:DOID:0080552); congenital disorder of glycosylation (Disease Ontology:DOID:5212)", "pathway": " (dme:Dmel_CG10688); (R-DME-446205)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537572;26940433", "class_list": "", "function": "Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions (PubMed:26940433). Required for maintaining N-linked glycoprotein glycosylation at the neuromuscular junction (NMJ) synaptomatrix, and thus acts in multiple pathways that prevent NMJ structural overgrowth, restrict synaptic bouton differentiation, and limit NMJ neurotransmission strength, in order to maintain viability, coordinate movement, and in adults ensure correct wing positioning (PubMed:26940433). Acts in the NMJ trans-synaptic Wg pathway via glycosylation of synaptic Mmp2 which enables dlp/wg signaling during development (PubMed:26940433)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.4.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.8", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004615 phosphomannomutase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0071456 cellular response to hypoxia;GO:0006487 protein N-linked glycosylation;GO:0006013 mannose metabolic process;GO:0061728 GDP-mannose biosynthetic process from mannose;GO:0061729 GDP-D-mannose biosynthetic process from fructose-6-phosphate", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VTZ6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VU02-1", "uniprot_id": [ { "id": "SMD1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VU02", "type": "external" } ], "mass": 13796.0, "length": 124, "protein_name": "Probable small nuclear ribonucleoprotein Sm D1", "gene_name": "SmD1", "organism": "Fruit fly", "refseq_name": "small ribonucleoprotein particle protein SmD1", "refseq_ac": [ { "id": "NP_524774", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524774", "type": "external" } ], "gene_names_uniprotkb": "SmD1; CG10753; snRNP69D", "gene_names_refseq": "BcDNA:RE39488; CG10753; D1-Sm; Dmel\\CG10753; SmD1; dD1; l(2)SH3 003; l(3)SH003; smd1; snRNP-69D; snRNP69D; snRNP", "protein_names_uniprotkb": "Probable small nuclear ribonucleoprotein Sm D1; Sm-D1; snRNP core protein D1", "protein_names_refseq": "CG10753-PA; SmD1-PA; lethal (3) SH003; small nuclear ribonucleoprotein at 69D; small ribonucleoprotein particle protein SmD1", "tax_id": 7227, "disease": "nephritis (Disease Ontology:DOID:10952); proteinuria (Disease Ontology:DOID:576); connective tissue disease (Disease Ontology:DOID:65); systemic lupus erythematosus (Disease Ontology:DOID:9074); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (dme:Dmel_CG10753); (R-DME-72163); (R-DME-72165); (R-DME-9770562); (R-DME-9943411)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;18369183;18621711", "class_list": "", "function": "Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B3DML3;Q8SYR6", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VU02-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VU52-1", "uniprot_id": [ { "id": "SNKY_DROME", "url": "https://www.uniprot.org/uniprot/Q9VU52", "type": "external" } ], "mass": 83340.0, "length": 715, "protein_name": "Protein sneaky", "gene_name": "snky", "organism": "Fruit fly", "refseq_name": "sneaky", "refseq_ac": [ { "id": "NP_648633", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648633", "type": "external" } ], "gene_names_uniprotkb": "snky; CG11281", "gene_names_refseq": "CG11281; Dmel\\CG11281; Snky; ms(3)4; ms(3)ry4; ms(3)sneaky; ms(3)snky; snky", "protein_names_uniprotkb": "Protein sneaky", "protein_names_refseq": "CG11281-PB; sneaky; snky-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11281)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;17092953;9630751", "class_list": "", "function": "Component of the sperm acrosome membrane (PubMed:17092953). Required for breakdown of the sperm plasma membrane after sperm entry into the egg, which is an essential prerequisite for successful fertilization (PubMed:17092953, PubMed:9630751)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0001669 acrosomal vesicle;GO:0002080 acrosomal membrane", "go_biological_process": "GO:0035045 sperm plasma membrane disassembly;GO:0035041 sperm DNA decondensation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VU52-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VUJ0-1", "uniprot_id": [ { "id": "RM39_DROME", "url": "https://www.uniprot.org/uniprot/Q9VUJ0", "type": "external" } ], "mass": 37324.0, "length": 333, "protein_name": "Large ribosomal subunit protein mL39", "gene_name": "mRpL39", "organism": "Fruit fly", "refseq_name": "mitochondrial ribosomal protein L39", "refseq_ac": [ { "id": "NP_524075", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524075", "type": "external" } ], "gene_names_uniprotkb": "mRpL39; CG17166; mRpL5", "gene_names_refseq": "CG17166; Dmel\\CG17166; MRP-L5; mRpL39; mRpL5", "protein_names_uniprotkb": "Large ribosomal subunit protein mL39; 39S ribosomal protein L39, mitochondrial; MRP-L39; MRP-L5", "protein_names_refseq": "CG17166-PA; mRpL39-PA; mitochondrial ribosomal protein L39; mitochondrial ribosomal protein L5", "tax_id": 7227, "disease": "combined oxidative phosphorylation deficiency (Disease Ontology:DOID:0060286)", "pathway": " (dme:Dmel_CG17166); (R-DME-5389840); (R-DME-5419276); (R-DME-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SYN5", "ec_number_list": [], "go_molecular_function": "GO:0000166 nucleotide binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion", "go_biological_process": "GO:0006417 regulation of translation;GO:0031047 regulatory ncRNA-mediated gene silencing;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VUJ0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VUL1-1", "uniprot_id": [ { "id": "PYRG_DROME", "url": "https://www.uniprot.org/uniprot/Q9VUL1", "type": "external" } ], "mass": 69448.0, "length": 627, "protein_name": "CTP synthase", "gene_name": "Ctps", "organism": "Fruit fly", "refseq_name": "CTP synthase, isoform C", "refseq_ac": [ { "id": "NP_001287067", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287067", "type": "external" } ], "gene_names_uniprotkb": "Ctps; CG45070; CG6854; CTP syn; CTPSyn; CTPS; CTPsyn; Dmel\\CG45070; Dmel_CG45070; ctps; dCTPS", "gene_names_refseq": "CG45070; CG6854; CTP syn; CTPSyn; CTPS; CTPsyn; Ctps; Dmel\\CG45070; ctps; dCTPS", "protein_names_uniprotkb": "CTP synthase; 6.3.4.2; CTP synthetase; UTP--ammonia ligase", "protein_names_refseq": "CG45070-PC; CTP synthase, isoform C; CTP synthetase; CTP-synthase; Ctps-PC; ctp synthase; cytidine synthase", "tax_id": 7227, "disease": "biliary tract benign neoplasm (Disease Ontology:DOID:0050625); immunodeficiency 24 (Disease Ontology:DOID:0111938); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dme:Dmel_CG45070); (R-DME-499943)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;20513629;23459760;25223282;25589440;26109356;26109357", "class_list": "", "function": "Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Required for assembly of cytoophidium in female germline cells (PubMed:23459760, PubMed:25223282). In nurse cells, CTPsyn filament assembly in the cytoophidium is regulated by Ack kinase which may thereby contribute to the control of CTP production at specific stages of oogenesis and development of the nurse cell membrane (PubMed:25223282)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VUL0", "ec_number_list": [ { "id": "6.3.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0003883 CTP synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0097268 cytoophidium", "go_biological_process": "GO:0044210 'de novo' CTP biosynthetic process;GO:0006241 CTP biosynthetic process;GO:0019856 pyrimidine nucleobase biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9VUL1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VUN3-1", "uniprot_id": [ { "id": "RANL_DROME", "url": "https://www.uniprot.org/uniprot/Q9VUN3", "type": "external" } ], "mass": 24781.0, "length": 217, "protein_name": "GTP-binding nuclear protein Ran-like", "gene_name": "Ran-like", "organism": "Fruit fly", "refseq_name": "Ran-like", "refseq_ac": [ { "id": "NP_524082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524082", "type": "external" } ], "gene_names_uniprotkb": "Ran-like; CG7815", "gene_names_refseq": "BcDNA:GH25818; CG7815; Dmel\\CG7815; Ran-like; anon-WO0140519.150; ran-like", "protein_names_uniprotkb": "GTP-binding nuclear protein Ran-like", "protein_names_refseq": "CG7815-PA; Ran-like-PA; Ran-like", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7815)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;12653959", "class_list": "", "function": "GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000054 ribosomal subunit export from nucleus;GO:0006611 protein export from nucleus;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VUN3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VUZ1-1", "uniprot_id": [ { "id": "TPPC2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VUZ1", "type": "external" } ], "mass": 16646.0, "length": 139, "protein_name": "Probable trafficking protein particle complex subunit 2", "gene_name": "Trs20", "organism": "Fruit fly", "refseq_name": "TRAPP subunit 20", "refseq_ac": [ { "id": "NP_648841", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648841", "type": "external" } ], "gene_names_uniprotkb": "Trs20; CG5161; l(3)72Dh", "gene_names_refseq": "BcDNA:RE62842; CG5161; Dmel\\CG5161; E(smoDN)B-left; Group B-left; TRAPP2C; TRAPPC2; Trs20p; Trs20; l(3)72Dh", "protein_names_uniprotkb": "Probable trafficking protein particle complex subunit 2; TRAPP subunit 20 ortholog", "protein_names_refseq": "CG5161-PA; TRAPP subunit 20 ortholog; TRAPP subunit 20; Trs20-PA; enhancer of smoDN group B-left; lethal (3) 72Dh", "tax_id": 7227, "disease": "X-linked spondyloepiphyseal dysplasia tarda (Disease Ontology:DOID:0080362); spondyloepiphyseal dysplasia congenita (Disease Ontology:DOID:14789)", "pathway": " (dme:Dmel_CG5161); (R-DME-204005); (R-DME-8876198)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;16862146;19934220", "class_list": "", "function": "May play a role in vesicular transport from endoplasmic reticulum to Golgi. Involved in dsRNA uptake., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SYG9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0048193 Golgi vesicle transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VUZ1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VV28-1", "uniprot_id": [ { "id": "NPLP3_DROME", "url": "https://www.uniprot.org/uniprot/Q9VV28", "type": "external" } ], "mass": 8688.0, "length": 90, "protein_name": "Neuropeptide-like 3", "gene_name": "Nplp3", "organism": "Fruit fly", "refseq_name": "Neuropeptide-like precursor 3", "refseq_ac": [ { "id": "NP_652710", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_652710", "type": "external" } ], "gene_names_uniprotkb": "Nplp3; CG13061", "gene_names_refseq": "BcDNA:RH16169; CG13061; CG18502; Dmel\\CG13061; NPLP3; NpIp3; Nplp3; SHA; VVIamide; nplp3", "protein_names_uniprotkb": "Neuropeptide-like 3", "protein_names_refseq": "CG13061-PA; Neuropeptide-like precursor 3; Nplp3-PA; SHA peptide; VVIamide peptide", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13061)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12171930;12537569;12537572;14690519", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VV28-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VV36-1", "uniprot_id": [ { "id": "RETIN_DROME", "url": "https://www.uniprot.org/uniprot/Q9VV36", "type": "external" } ], "mass": 20004.0, "length": 191, "protein_name": "Retinin", "gene_name": "retinin", "organism": "Fruit fly", "refseq_name": "retinin", "refseq_ac": [ { "id": "NP_524995", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524995", "type": "external" } ], "gene_names_uniprotkb": "retinin; CG13057", "gene_names_refseq": "4A11; CG13057; Dmel\\CG13057; retinin", "protein_names_uniprotkb": "Retinin", "protein_names_refseq": "CG13057-PA; retinin-PA; retinin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13057)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;18828839;2105491", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SYA5;Q95TE5;Q9N2Q4", "ec_number_list": [], "go_molecular_function": "GO:0005212 structural constituent of eye lens", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VV36-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VVD9-1", "uniprot_id": [ { "id": "S35B3_DROME", "url": "https://www.uniprot.org/uniprot/Q9VVD9", "type": "external" } ], "mass": 43883.0, "length": 396, "protein_name": "Adenosine 3'-phospho 5'-phosphosulfate transporter 2", "gene_name": "Papst2", "organism": "Fruit fly", "refseq_name": "PAPS transporter 2", "refseq_ac": [ { "id": "NP_648954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648954", "type": "external" } ], "gene_names_uniprotkb": "Papst2; CG7853", "gene_names_refseq": "CG7853; Dmel\\CG7853; PAPST2; Papst2; dPAPST2", "protein_names_uniprotkb": "Adenosine 3'-phospho 5'-phosphosulfate transporter 2; PAPS transporter 2; Solute carrier family 35 member B3 homolog; dPAPST2", "protein_names_refseq": "CG7853-PA; PAPS transporter 2; Papst2-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7853); (R-DME-174362); (R-DME-727802)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;16873373;18327897", "class_list": "", "function": "Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Essential for viability. Involved in glycosaminoglycan synthesis and the subsequent signaling. May be involved in hh and dpp signaling by controlling the sulfation of heparan sulfate (HS)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0PCZ5;Q8T012", "ec_number_list": [], "go_molecular_function": "GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0000137 Golgi cis cisterna", "go_biological_process": "GO:0055085 transmembrane transport;GO:0015012 heparan sulfate proteoglycan biosynthetic process;GO:0046963 3'-phosphoadenosine 5'-phosphosulfate transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VVD9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VVE2-1", "uniprot_id": [ { "id": "ROGDI_DROME", "url": "https://www.uniprot.org/uniprot/Q9VVE2", "type": "external" } ], "mass": 30495.0, "length": 268, "protein_name": "Protein rogdi", "gene_name": "rogdi", "organism": "Fruit fly", "refseq_name": "rogdi, isoform A", "refseq_ac": [ { "id": "NP_648956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648956", "type": "external" } ], "gene_names_uniprotkb": "rogdi; CG7725", "gene_names_refseq": "CG7725; Dmel\\CG7725; Rogdi; rogdi", "protein_names_uniprotkb": "Protein rogdi", "protein_names_refseq": "CG7725-PA; rogdi, isoform A; rogdi-PA", "tax_id": 7227, "disease": "Kohlschutter-Tonz syndrome (Disease Ontology:DOID:0111668)", "pathway": " (dme:Dmel_CG7725)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;28900300", "class_list": "", "function": "Plays a role in promoting sleep by enhancing metabotropic transmission of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in GABAergic neurons upstream of a wake-inducing dopaminergic pathway., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32KF2;Q8IQP4;Q95T16", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0043291 RAVE complex;GO:0005635 nuclear envelope;GO:0030424 axon;GO:0030425 dendrite;GO:0043204 perikaryon", "go_biological_process": "GO:0048149 behavioral response to ethanol;GO:0030431 sleep;GO:0061534 gamma-aminobutyric acid secretion, neurotransmission", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VVE2-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VVF3-1", "uniprot_id": [ { "id": "OR74A_DROME", "url": "https://www.uniprot.org/uniprot/Q9VVF3", "type": "external" } ], "mass": 47415.0, "length": 404, "protein_name": "Odorant receptor 74a", "gene_name": "Or74a", "organism": "Fruit fly", "refseq_name": "odorant receptor 74a", "refseq_ac": [ { "id": "NP_524123", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524123", "type": "external" } ], "gene_names_uniprotkb": "Or74a; CG13726", "gene_names_refseq": "74A.1; 74a; CG13726; DOR26; Dmel\\CG13726; OR74a; Or74a", "protein_names_uniprotkb": "Odorant receptor 74a", "protein_names_refseq": "CG13726-PA; Or74a-PA; odorant receptor 74a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13726)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;21613503;21857978", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to octanol, anisole, and 2-heptanone., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VVF3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VVH9-1", "uniprot_id": [ { "id": "SO74D_DROME", "url": "https://www.uniprot.org/uniprot/Q9VVH9", "type": "external" } ], "mass": 88506.0, "length": 819, "protein_name": "Solute carrier organic anion transporter family member 74D", "gene_name": "Oatp74D", "organism": "Fruit fly", "refseq_name": "organic anion transporting polypeptide 74D, isoform C", "refseq_ac": [ { "id": "NP_001163460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163460", "type": "external" } ], "gene_names_uniprotkb": "Oatp74D; CG7571", "gene_names_refseq": "CG7571; Dmel\\CG7571; EcI; Oatp74D; oatp 74D", "protein_names_uniprotkb": "Solute carrier organic anion transporter family member 74D; EcI; Ecdysone Importer; Organic anion transporting polypeptide 74D", "protein_names_refseq": "CG7571-PC; Oatp74D-PC; ecdysone importer; organic anion transporting polypeptide 74D, isoform C", "tax_id": 7227, "disease": "primary biliary cholangitis (Disease Ontology:DOID:12236); Dubin-Johnson syndrome (Disease Ontology:DOID:12308); cholestasis (Disease Ontology:DOID:13580); bilirubin metabolic disorder (Disease Ontology:DOID:2741); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (dme:Dmel_CG7571); (R-DME-6798695); (R-DME-879518)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;30293839", "class_list": "", "function": "Transporter that mediates the cellular uptake of ecdysteroids, including ecdysone, from the hemolymph., [UniProtKB, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 6, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0055085 transmembrane transport;GO:0015711 organic anion transport;GO:0043252 sodium-independent organic anion transport;GO:0002164 larval development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VVH9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VVL1-1", "uniprot_id": [ { "id": "IR75A_DROME", "url": "https://www.uniprot.org/uniprot/Q9VVL1", "type": "external" } ], "mass": 72760.0, "length": 629, "protein_name": "Ionotropic receptor 75a", "gene_name": "Ir75a", "organism": "Fruit fly", "refseq_name": "ionotropic receptor 75a", "refseq_ac": [ { "id": "NP_649012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649012", "type": "external" } ], "gene_names_uniprotkb": "Ir75a; CG14585", "gene_names_refseq": "75a; CG14585; DmIr75a; DmelIR75a; Dmel\\CG14585; IR75abc; IR75a; Ir75abc; Ir75a", "protein_names_uniprotkb": "Ionotropic receptor 75a", "protein_names_refseq": "CG14585-PB; Ir75a-PB; ionotropic receptor 75a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14585)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;21220098;27776356", "class_list": "", "function": "Odorant receptor for acetic and propionic acid. Functions as part of an olfactory receptor complex including the ionotropic receptor coreceptor Ir8a., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "E7E521", "ec_number_list": [], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0044297 cell body;GO:0071683 sensory dendrite", "go_biological_process": "GO:0050907 detection of chemical stimulus involved in sensory perception;GO:0007605 sensory perception of sound;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VVL1-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VVN2-1", "uniprot_id": [ { "id": "RT26_DROME", "url": "https://www.uniprot.org/uniprot/Q9VVN2", "type": "external" } ], "mass": 26264.0, "length": 225, "protein_name": "Small ribosomal subunit protein mS26", "gene_name": "mRpS26", "organism": "Fruit fly", "refseq_name": "mitochondrial ribosomal protein S26", "refseq_ac": [ { "id": "NP_524134", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524134", "type": "external" } ], "gene_names_uniprotkb": "mRpS26; CG7354", "gene_names_refseq": "CG7354; Dmel\\CG7354; MRP-S26; mRpS26", "protein_names_uniprotkb": "Small ribosomal subunit protein mS26; 28S ribosomal protein S26, mitochondrial; MRP-S26; S26mt", "protein_names_refseq": "CG7354-PA; mRpS26-PA; mitochondrial ribosomal protein S26", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7354); (R-DME-5389840); (R-DME-5419276); (R-DME-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VVN2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VVR1-1", "uniprot_id": [ { "id": "NOT_DROME", "url": "https://www.uniprot.org/uniprot/Q9VVR1", "type": "external" } ], "mass": 56441.0, "length": 496, "protein_name": "Ubiquitin carboxyl-terminal hydrolase nonstop", "gene_name": "not", "organism": "Fruit fly", "refseq_name": "non-stop, isoform C", "refseq_ac": [ { "id": "NP_001287106", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287106", "type": "external" } ], "gene_names_uniprotkb": "not; CG4166; Dmel\\CG4166; Dmel_CG4166; NOT; Non-stop; Nonstop; Not; Q9VVR1; UBP8; USP22; Upb8; anon-WO0257455.9; dNonStop; dNonstop; i155; l(3)02069; l(3)j9A6; nonstop", "gene_names_refseq": "CG4166; Dmel\\CG4166; NOT; Non-stop; Nonstop; Not; Q9VVR1; UBP8; USP22; Upb8; anon-WO0257455.9; dNonStop; dNonstop; i155; l(3)02069; l(3)j9A6; nonstop; not", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase nonstop; 3.4.19.12; Deubiquitinating enzyme nonstop; Ubiquitin thioesterase nonstop; Ubiquitin-specific-processing protease nonstop", "protein_names_refseq": "CG4166-PC; Non-stop; non-stop, isoform C; nonstop; not-PC", "tax_id": 7227, "disease": "non-syndromic X-linked intellectual disability 105 (Disease Ontology:DOID:0112036); glioblastoma (Disease Ontology:DOID:3068)", "pathway": " (dme:Dmel_CG4166); (R-DME-5689880)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10731132;11182084;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18188155;18206972;25589440;26109356;26109357", "class_list": "", "function": "Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of histone H2B, thereby acting as a coactivator in a large subset of genes. Required to counteract heterochromatin silencing. Controls the development of neuronal connectivity in visual system by being required for accurate axon targeting in the optic lobe. Required for expression of ecdysone-induced genes such as br/broad., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95TK9;Q9U6Q9;X2JCK7", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0071819 DUBm complex;GO:0000124 SAGA complex;GO:0070461 SAGA-type complex", "go_biological_process": "GO:0021782 glial cell development;GO:0006351 DNA-templated transcription;GO:0016579 protein deubiquitination;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9VVR1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VVR6-1", "uniprot_id": [ { "id": "SGF11_DROME", "url": "https://www.uniprot.org/uniprot/Q9VVR6", "type": "external" } ], "mass": 21322.0, "length": 196, "protein_name": "SAGA-associated factor 11 homolog", "gene_name": "Sgf11", "organism": "Fruit fly", "refseq_name": "SAGA associated factor 11kDa", "refseq_ac": [ { "id": "NP_001097638", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097638", "type": "external" } ], "gene_names_uniprotkb": "Sgf11; CG13379", "gene_names_refseq": "CG13379; Dmel\\CG13379; Sgf11; dSgf11; sgf11", "protein_names_uniprotkb": "SAGA-associated factor 11 homolog", "protein_names_refseq": "CG13379-PB; SAGA associated factor 11kDa; Sgf11-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13379)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537572;18188155;18206972;18327897;22989713", "class_list": "", "function": "Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Binds independently on SAGA to promoters in an RNA-dependent manner. Binds to mRNA and is essential for total mRNA export from the nucleus. Required to counteract heterochromatin silencing. Controls the development of neuronal connectivity in visual system by being required for accurate axon targeting in the optic lobe. Required for expression of ecdysone-induced genes such as br/broad., [UniProtKB, PubMed, PubMed, PubMed, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V5G1;Q4V623", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0071819 DUBm complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006406 mRNA export from nucleus;GO:0015031 protein transport;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VVR6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VVW3-1", "uniprot_id": [ { "id": "SFXN2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VVW3", "type": "external" } ], "mass": 36496.0, "length": 327, "protein_name": "Sideroflexin-2", "gene_name": "Sfxn2", "organism": "Fruit fly", "refseq_name": "sideroflexin 2", "refseq_ac": [ { "id": "NP_649086", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649086", "type": "external" } ], "gene_names_uniprotkb": "Sfxn2; CG6812", "gene_names_refseq": "CG6812; Dmel\\CG6812; SFXN3; Sfxn2", "protein_names_uniprotkb": "Sideroflexin-2", "protein_names_refseq": "CG6812-PA; Sfxn2-PA; sideroflexin 2; sideroflexin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6812)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;30442778", "class_list": "", "function": "Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SZ96", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015194 L-serine transmembrane transporter activity;GO:0015075 monoatomic ion transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006730 one-carbon metabolic process;GO:1990542 mitochondrial transmembrane transport;GO:0140300 serine import into mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VVW3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VVX0-1", "uniprot_id": [ { "id": "GEMI2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VVX0", "type": "external" } ], "mass": 28751.0, "length": 245, "protein_name": "Gem-associated protein 2", "gene_name": "Gem2", "organism": "Fruit fly", "refseq_name": "gemin 2, isoform B", "refseq_ac": [ { "id": "NP_001262034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262034", "type": "external" } ], "gene_names_uniprotkb": "Gem2; CG10419", "gene_names_refseq": "CG10419; Dmel\\CG10419; Gem2; dGem2", "protein_names_uniprotkb": "Gem-associated protein 2; Gemin2", "protein_names_refseq": "CG10419-PB; Gem2-PB; Gemin2; dGemin2; gemin 2, isoform B", "tax_id": 7227, "disease": "spinal muscular atrophy (Disease Ontology:DOID:12377)", "pathway": " (dme:Dmel_CG10419)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10731132;12537572;18621711;20452345;23333303;24391840;26098872;30563832", "class_list": "", "function": "Component of the survival motor neuron (SMN) complex that catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:18621711, PubMed:23333303, PubMed:30563832). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (By similarity). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG (5Sm) are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (By similarity). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A (By similarity). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (By similarity). Within the SMN complex, GEMIN2 constrains the conformation of 5Sm, thereby promoting 5Sm binding to snRNA containing the snRNP code (a nonameric Sm site and a 3'-adjacent stem-loop), thus preventing progression of assembly until a cognate substrate is bound (By similarity). Involved in adult motor function (PubMed:26098872)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7K0M0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005681 spliceosomal complex;GO:0032797 SMN complex;GO:0034718 SMN-Gemin2 complex;GO:0071254 cytoplasmic U snRNP body", "go_biological_process": "GO:0008344 adult locomotory behavior;GO:0000387 spliceosomal snRNP assembly;GO:0000245 spliceosomal complex assembly;GO:0022618 protein-RNA complex assembly;GO:0007629 flight behavior", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9VVX0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VW09-1", "uniprot_id": [ { "id": "LTN1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VW09", "type": "external" } ], "mass": 198640.0, "length": 1747, "protein_name": "E3 ubiquitin-protein ligase listerin", "gene_name": "Ltn1", "organism": "Fruit fly", "refseq_name": "listerin E3 ubiquitin protein ligase 1", "refseq_ac": [ { "id": "NP_730427", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_730427", "type": "external" } ], "gene_names_uniprotkb": "Ltn1; CG32210; l(3)76BDr", "gene_names_refseq": "CG32210; CG9268; CG9274; Dmel\\CG32210; Ltn1; l(3)76BDr", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase listerin; 2.3.2.27; Listerin E3 ubiquitin protein ligase 1; RING-type E3 ubiquitin transferase listerin", "protein_names_refseq": "CG32210-PA; Ltn1-PA; l(3)76BDr; listerin E3 ubiquitin protein ligase 1; listerin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32210); (R-DME-983168); (R-DME-9954709)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;18327897;25128630", "class_list": "", "function": "E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:25128630). Ubiquitination leads to TER94/VCP recruitment for extraction and degradation of the incomplete translation product (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8T3L4", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0043023 ribosomal large subunit binding", "go_cellular_component": "GO:0005829 cytosol;GO:1990112 RQC complex", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0016567 protein ubiquitination;GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VW09-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VW26-1", "uniprot_id": [ { "id": "OAT_DROME", "url": "https://www.uniprot.org/uniprot/Q9VW26", "type": "external" } ], "mass": 47312.0, "length": 431, "protein_name": "Ornithine aminotransferase, mitochondrial", "gene_name": "Oat", "organism": "Fruit fly", "refseq_name": "ornithine aminotransferase precursor", "refseq_ac": [ { "id": "NP_649139", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649139", "type": "external" } ], "gene_names_uniprotkb": "Oat; CG8782", "gene_names_refseq": "151832_at; CG8782; Dmel\\CG8782; Oat", "protein_names_uniprotkb": "Ornithine aminotransferase, mitochondrial; 2.6.1.13; Ornithine--oxo-acid aminotransferase", "protein_names_refseq": "CG8782-PA; Oat-PA; ornithine aminotransferase precursor; ornithine aminotransferase", "tax_id": 7227, "disease": "gyrate atrophy (Disease Ontology:DOID:1415); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (dme:Dmel_CG8782); (R-DME-8964539)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.6.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.13", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0004587 ornithine aminotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006591 ornithine metabolic process;GO:0055129 L-proline biosynthetic process;GO:0010121 L-arginine catabolic process to proline via ornithine;GO:0019544 L-arginine catabolic process to L-glutamate", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VW26-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VW58-1", "uniprot_id": [ { "id": "Q9VW58_DROME", "url": "https://www.uniprot.org/uniprot/Q9VW58", "type": "external" } ], "mass": 31077.0, "length": 269, "protein_name": "Metaxin-2", "gene_name": "Mtx2", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_649161", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649161", "type": "external" } ], "gene_names_uniprotkb": "Mtx2; CG8004; Dmel\\CG8004; Dmel_CG8004", "gene_names_refseq": "CG8004; Dmel\\CG8004", "protein_names_uniprotkb": "Metaxin-2", "protein_names_refseq": "CG8004-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8004)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0001401 SAM complex;GO:0005739 mitochondrion;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0045040 protein insertion into mitochondrial outer membrane;GO:0015031 protein transport;GO:0019896 axonal transport of mitochondrion;GO:0070096 mitochondrial outer membrane translocase complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VW58-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VW87-1", "uniprot_id": [ { "id": "SSK_DROME", "url": "https://www.uniprot.org/uniprot/Q9VW87", "type": "external" } ], "mass": 17637.0, "length": 162, "protein_name": "Protein snakeskin", "gene_name": "Ssk", "organism": "Fruit fly", "refseq_name": "snakeskin, isoform A", "refseq_ac": [ { "id": "NP_649184", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649184", "type": "external" } ], "gene_names_uniprotkb": "Ssk; CG6981", "gene_names_refseq": "CG6981; CT21613; Dmel\\CG6981; Ssk; ssk", "protein_names_uniprotkb": "Protein snakeskin", "protein_names_refseq": "CG6981-PA; Ssk-PA; snakeskin, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6981)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;22328496;22854041;26848177", "class_list": "", "function": "Required for assembly of smooth septate junctions (sSJs), together with mesh and Tsp2A (PubMed:22854041, PubMed:26848177). May be important for barrier function of the midgut epithelium., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D5A7R8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016327 apicolateral plasma membrane;GO:0005920 smooth septate junction", "go_biological_process": "GO:0007496 anterior midgut development;GO:0019991 septate junction assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VW87-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VWD9-1", "uniprot_id": [ { "id": "Q9VWD9_DROME", "url": "https://www.uniprot.org/uniprot/Q9VWD9", "type": "external" } ], "mass": 58836.0, "length": 547, "protein_name": "Ubiquilin-like protein", "gene_name": "Ubqn", "organism": "Fruit fly", "refseq_name": "ubiquilin, isoform B", "refseq_ac": [ { "id": "NP_001285457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285457", "type": "external" } ], "gene_names_uniprotkb": "Ubqn; BEST:LD26923; CG14224; Chap; DSK2; Dmel\\CG14224; Dmel_CG14224; Dsk2; UBQLN homolog; UBQLN1; UBQLN; anon-18DEa; clone 5.42; dUbqln; dUbqn; dsk2; ubqn", "gene_names_refseq": "BEST:LD26923; CG14224; Chap; DSK2; Dmel\\CG14224; Dsk2; UBQLN homolog; UBQLN1; UBQLN; Ubqn; anon-18DEa; clone 5.42; dUbqln; dUbqn; dsk2; ubqn", "protein_names_uniprotkb": "Ubiquilin-like protein", "protein_names_refseq": "CG14224-PB; Ubqn-PB; ubiquilin 1; ubiquilin, isoform B", "tax_id": 7227, "disease": "amyotrophic lateral sclerosis type 15 (Disease Ontology:DOID:0060206); neurodegenerative disease (Disease Ontology:DOID:1289); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); frontotemporal dementia (Disease Ontology:DOID:9255)", "pathway": " (dme:Dmel_CG14224); (R-DME-8856825)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031593 polyubiquitin modification-dependent protein binding;GO:0070628 proteasome binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0042982 amyloid precursor protein metabolic process;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VWD9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VWI0-1", "uniprot_id": [ { "id": "NDUS4_DROME", "url": "https://www.uniprot.org/uniprot/Q9VWI0", "type": "external" } ], "mass": 20681.0, "length": 183, "protein_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial", "gene_name": "ND-18", "organism": "Fruit fly", "refseq_name": "NADH dehydrogenase (ubiquinone) 18 kDa subunit", "refseq_ac": [ { "id": "NP_573385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573385", "type": "external" } ], "gene_names_uniprotkb": "ND-18; CG12203; NUYM; dNDUFS4", "gene_names_refseq": "CG12203; Dmel\\CG12203; IP11020p; ND-18; NDUFS4; NUYM; Q9VWI0; dNDUFS4", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial", "protein_names_refseq": "CG12203-PA; FBpp0074481; NADH dehydrogenase (ubiquinone) 18 kDa subunit; NADH ubiquinone oxidoreductase 18 kDa; NADH-ubiquinone oxidoreductase 18 kDa subunit; NADH:ubiquinone oxidoreductase 18 kDa subunit; ND-18-PA", "tax_id": 7227, "disease": "mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); nuclear type mitochondrial complex I deficiency 1 (Disease Ontology:DOID:0112074); Leigh disease (Disease Ontology:DOID:3652); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (dme:Dmel_CG12203); (R-DME-611105); (R-DME-6799198)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;20433953;25594180", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1EC13;Q8SZL0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0022904 respiratory electron transport chain;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VWI0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VWP4-1", "uniprot_id": [ { "id": "SUOX_DROME", "url": "https://www.uniprot.org/uniprot/Q9VWP4", "type": "external" } ], "mass": 64346.0, "length": 573, "protein_name": "Sulfite oxidase, mitochondrial", "gene_name": "shop", "organism": "Fruit fly", "refseq_name": "shopper", "refseq_ac": [ { "id": "NP_573331", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573331", "type": "external" } ], "gene_names_uniprotkb": "shop; CG7280", "gene_names_refseq": "CG7280; Dmel\\CG7280; Suox; shop", "protein_names_uniprotkb": "Sulfite oxidase, mitochondrial; 1.8.3.1; Protein shopper", "protein_names_refseq": "CG7280-PA; shop-PA; shopper; sulfite oxidase", "tax_id": 7227, "disease": "isolated sulfite oxidase deficiency (Disease Ontology:DOID:0111270); inherited metabolic disorder (Disease Ontology:DOID:655); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (dme:Dmel_CG7280); (R-DME-1614517)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;30158546", "class_list": "", "function": "Required in ensheathing glial cells for normal larval locomotion. Oxidizes sulfite which is required to maintain glutamate homeostasis and as a consequence, neuronal network function., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.1", "type": "external" } ], "go_molecular_function": "GO:0030151 molybdenum ion binding;GO:0020037 heme binding;GO:0043546 molybdopterin cofactor binding;GO:0008482 sulfite oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0006790 sulfur compound metabolic process;GO:0030642 intracellular sulfate ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VWP4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VWQ2-1", "uniprot_id": [ { "id": "S6KL_DROME", "url": "https://www.uniprot.org/uniprot/Q9VWQ2", "type": "external" } ], "mass": 55372.0, "length": 483, "protein_name": "Serine/threonine-protein kinase S6KL", "gene_name": "S6KL", "organism": "Fruit fly", "refseq_name": "S6 kinase like, isoform B", "refseq_ac": [ { "id": "NP_001245742", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245742", "type": "external" } ], "gene_names_uniprotkb": "S6KL; Bin4; CG7001; Pk17E", "gene_names_refseq": "3-10; BIN4; BcdK; Bin4; CG7001; Dmel\\CG7001; PK17E; Pk17E; Pk?4; S6KL; bin4; pk17e", "protein_names_uniprotkb": "Serine/threonine-protein kinase S6KL; 2.7.11.-; Protein kinase-like 17E; S6 kinase-like protein", "protein_names_refseq": "Bcd interacting protein K; CG7001-PB; S6 kinase like, isoform B; S6KL-PB; bicoid interacting protein 4; protein kinase-like 17E", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7001); (R-DME-198693)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10717484;10731132;12537572;25748449", "class_list": "", "function": "Displays kinase activity. Inhibits neuromuscular junction (NMJ) growth by interacting with and promoting the proteasome-mediated degradation of the receptor tkv which inhibits bone morphogenetic protein (BMP) signaling., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EQU9;M9NEP2;M9NFD4;O96630", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0030514 negative regulation of BMP signaling pathway;GO:0038202 TORC1 signaling;GO:1904397 negative regulation of neuromuscular junction development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VWQ2-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VWU1-1", "uniprot_id": [ { "id": "PSH_DROME", "url": "https://www.uniprot.org/uniprot/Q9VWU1", "type": "external" } ], "mass": 42228.0, "length": 394, "protein_name": "Serine protease persephone", "gene_name": "psh", "organism": "Fruit fly", "refseq_name": "persephone", "refseq_ac": [ { "id": "NP_573297", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573297", "type": "external" } ], "gene_names_uniprotkb": "psh; CG6367", "gene_names_refseq": "CG6367; Dmel\\CG6367; PSH; Psh; SP28; c-SP28; cSP28; psh", "protein_names_uniprotkb": "Serine protease persephone; 3.4.21.-", "protein_names_refseq": "CG6367-PA; persephone; psh-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6367)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10731132;12098703;12537569;12537572;16399077;17465907;18724373;21576362", "class_list": "", "function": "Serine protease that plays a key role in innate immunity in response to Gram-positive bacterial and fungal proteases (PubMed:12098703, PubMed:16399077, PubMed:18724373). Acts as a component of the Toll pathway upstream of protease spz processing enzyme SPE and Tl ligand spz (PubMed:12098703, PubMed:16399077, PubMed:18724373). Nec regulates the cascade by inhibiting psh (PubMed:12098703)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A4V9U0;A4V9U1;A4V9U4;A4V9U7", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0045087 innate immune response;GO:0050830 defense response to Gram-positive bacterium;GO:0050832 defense response to fungus;GO:0071219 cellular response to molecule of bacterial origin", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9VWU1-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VXA0-1", "uniprot_id": [ { "id": "NPRL2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VXA0", "type": "external" } ], "mass": 46345.0, "length": 412, "protein_name": "GATOR complex protein NPRL2", "gene_name": "Nprl2", "organism": "Fruit fly", "refseq_name": "nitrogen permease regulator-like 2", "refseq_ac": [ { "id": "NP_573174", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573174", "type": "external" } ], "gene_names_uniprotkb": "Nprl2; CG9104", "gene_names_refseq": "CG9104; Dmel\\CG9104; GATOR1; NPR2; Nplr2; Npr2; Nprl2; npr2; nprl2; nprl", "protein_names_uniprotkb": "GATOR complex protein NPRL2; Nitrogen permease regulator 2-like protein", "protein_names_refseq": "CG9104-PA; Nprl2-PA; nitrogen permease regulator-like 2", "tax_id": 7227, "disease": "familial focal epilepsy with variable foci 2 (Disease Ontology:DOID:0081422)", "pathway": " (dme:Dmel_CG9104)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10731132;12537569;12537572;23723238;24786828;25512509;27166823;27672113", "class_list": "", "function": "An essential component of the GATOR subcomplex GATOR1 which functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:25512509, PubMed:27166823). The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation (PubMed:23723238, PubMed:25512509, PubMed:27166823). The function of GATOR1 in negatively regulating the TORC1 pathway is essential for maintaining baseline levels of TORC1 activity under nutrient rich conditions, and for promoting survival during amino acid or complete starvation by inhibiting TORC1-dependent cell growth and promoting catabolic metabolism and autophagy (PubMed:23723238, PubMed:27166823). In addition, this inhibition of TORC1 is necessary to maintain female fertility under normal conditions and during periods of nutrient stress (PubMed:24786828, PubMed:25512509, PubMed:27672113). GATOR1 and GATOR2 act at different stages of oogenesis to regulate TORC1 in order to control meiotic entry and promote oocyte growth and development (PubMed:25512509). After exactly four mitotic cyst divisions, the GATOR1 complex members (Iml1, Nprl2 and Nprl3) down-regulate TORC1 to slow cellular metabolism and promote the mitotic/meiotic transition (PubMed:25512509). At later stages of oogenesis, the mio and Nup44A components of the GATOR2 complex inhibit GATOR1 and thus activate TORC1 to promote meiotic progression, and drive oocyte growth and development (PubMed:25512509)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005774 vacuolar membrane;GO:0044754 autolysosome;GO:1990130 GATOR1 complex", "go_biological_process": "GO:0010898 positive regulation of triglyceride catabolic process;GO:0051301 cell division;GO:0032007 negative regulation of TOR signaling;GO:0009267 cellular response to starvation;GO:0045792 negative regulation of cell size", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9VXA0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VXB3-1", "uniprot_id": [ { "id": "SAP30_DROME", "url": "https://www.uniprot.org/uniprot/Q9VXB3", "type": "external" } ], "mass": 20192.0, "length": 173, "protein_name": "Histone deacetylase complex subunit SAP30 homolog", "gene_name": "Sap30", "organism": "Fruit fly", "refseq_name": "SIN3-associated polypeptide 30, isoform B", "refseq_ac": [ { "id": "NP_001285352", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285352", "type": "external" } ], "gene_names_uniprotkb": "Sap30; CG4756; Dmel\\CG4756; Dmel_CG4756; SAP30; cg4756", "gene_names_refseq": "CG4756; Dmel\\CG4756; SAP30; Sap30; cg4756", "protein_names_uniprotkb": "Histone deacetylase complex subunit SAP30 homolog; SIN3-associated polypeptide 30", "protein_names_refseq": "CG4756-PB; SIN3-associated polypeptide 30, isoform B; Sap30-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4756); (R-DME-3214815)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;12077326;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Component of the class 1 Sin3A-histone deacetylase (HDAC1/Rpd3) complex (HDAC). Appears to be a non-essential subunit of this complex which is not required for cell cycle regulation of progression through the G2 phase of the cell cycle., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0000118 histone deacetylase complex;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0010389 regulation of G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VXB3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VXD9-1", "uniprot_id": [ { "id": "MTH1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VXD9", "type": "external" } ], "mass": 74466.0, "length": 676, "protein_name": "Probable G protein-coupled receptor Mth-like 1", "gene_name": "mthl1", "organism": "Fruit fly", "refseq_name": "methuselah-like 1, isoform B", "refseq_ac": [ { "id": "NP_001285340", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285340", "type": "external" } ], "gene_names_uniprotkb": "mthl1; CG4521; Dmel\\CG4521; Dmel_CG4521; Mist; Mth-1; anon-WO0170980.22; anon-WO0170980.23; mist", "gene_names_refseq": "CG4521; Dmel\\CG4521; Mist; Mth-1; anon-WO0170980.22; anon-WO0170980.23; mist; mthl1", "protein_names_uniprotkb": "Probable G protein-coupled receptor Mth-like 1; Protein methuselah-like 1", "protein_names_refseq": "CG4521-PB; Methuselah-like 1; mesoderm-invagination signal transducer; methuselah-like 1, isoform B; mist; mth-like 1; mthl1-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4521)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;10908591;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0042594 response to starvation;GO:0007369 gastrulation;GO:0008340 determination of adult lifespan", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VXD9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VXE0-1", "uniprot_id": [ { "id": "RUXG_DROME", "url": "https://www.uniprot.org/uniprot/Q9VXE0", "type": "external" } ], "mass": 8538.0, "length": 76, "protein_name": "Probable small nuclear ribonucleoprotein G", "gene_name": "SNRPG", "organism": "Fruit fly", "refseq_name": "small nuclear ribonucleoprotein G, isoform B", "refseq_ac": [ { "id": "NP_001138209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138209", "type": "external" } ], "gene_names_uniprotkb": "SNRPG; CG9742; SmG", "gene_names_refseq": "BcDNA:RE61341; BcDNA:RH35475; CG9742; Dmel\\CG9742; G-Sm; G; HD10913; SNRPG; SmG; dG; snRNPG", "protein_names_uniprotkb": "Probable small nuclear ribonucleoprotein G; Sm protein G; Sm-G; SmG; snRNP-G", "protein_names_refseq": "CG9742-PB; SNRPG-PB; small nuclear ribonucleoprotein G, isoform B; small ribonucleoprotein G; small ribonucleoprotein particle protein SmG; snRNPG", "tax_id": 7227, "disease": "nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (dme:Dmel_CG9742); (R-DME-111367); (R-DME-72163); (R-DME-72165); (R-DME-73856); (R-DME-77588); (R-DME-9770562); (R-DME-9943411)", "pathway_count": 8, "publication_count": 5, "publication_id_list": "10731132;10908584;12537569;12537572;18621711", "class_list": "", "function": "Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:18621711). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7Z0Y9;Q8MYW8", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0036261 7-methylguanosine cap hypermethylation;GO:0000398 mRNA splicing, via spliceosome;GO:0071045 nuclear histone mRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VXE0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VXE5-1", "uniprot_id": [ { "id": "PAKM_DROME", "url": "https://www.uniprot.org/uniprot/Q9VXE5", "type": "external" } ], "mass": 69620.0, "length": 639, "protein_name": "Serine/threonine-protein kinase PAK mbt", "gene_name": "mbt", "organism": "Fruit fly", "refseq_name": "mushroom bodies tiny", "refseq_ac": [ { "id": "NP_523375", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523375", "type": "external" } ], "gene_names_uniprotkb": "mbt; CG18582", "gene_names_refseq": "CG18582; DmMBT; DmPAK2; Dmel\\CG18582; Mbt; PAK2; PAK; Pak2; STE20; Ste20; anon-EST:fe1G7; dPAK2; mbt", "protein_names_uniprotkb": "Serine/threonine-protein kinase PAK mbt; 2.7.11.1; Protein mushroom bodies tiny; p21-activated kinase-related protein", "protein_names_refseq": "CG18582-PA; anon-fast-evolving-1G7; mbt-PA; mushroom bodies tiny", "tax_id": 7227, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); clear cell renal cell carcinoma (Disease Ontology:DOID:4467)", "pathway": " (dme:Dmel_CG18582); (R-DME-9013149); (R-DME-9013406); (R-DME-9013407); (R-DME-9013420); (R-DME-9013423); (R-DME-9013424)", "pathway_count": 7, "publication_count": 6, "publication_id_list": "10731132;12490550;12537569;12537572;18327897;9811608", "class_list": "", "function": "Involved in neurogenesis of the adult central nervous system, and together with Cdc42, regulates photoreceptor cell morphogenesis. Phosphorylates exogenous substrates when activated by Cdc42., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O96372;Q960J8;Q9TYH2", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "5.6.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.8", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0031267 small GTPase binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0048749 compound eye development;GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0007010 cytoskeleton organization;GO:0048639 positive regulation of developmental growth", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VXE5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VXL0-1", "uniprot_id": [ { "id": "OR13A_DROME", "url": "https://www.uniprot.org/uniprot/Q9VXL0", "type": "external" } ], "mass": 48264.0, "length": 418, "protein_name": "Odorant receptor 13a", "gene_name": "Or13a", "organism": "Fruit fly", "refseq_name": "odorant receptor 13a", "refseq_ac": [ { "id": "NP_523359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523359", "type": "external" } ], "gene_names_uniprotkb": "Or13a; CG12697", "gene_names_refseq": "13F.1; 13a; CG12697; DOR38; Dmel\\CG12697; OR13a; Or13a; dOr13a; or13a", "protein_names_uniprotkb": "Odorant receptor 13a", "protein_names_refseq": "CG12697-PA; Or13a-PA; odorant receptor 13a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12697)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;10943836;12537572;20371823;21613503;21857978", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to octanol, nonanol, and pentyl acetate., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VXL0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VXN0-1", "uniprot_id": [ { "id": "QTMAN_DROME", "url": "https://www.uniprot.org/uniprot/Q9VXN0", "type": "external" } ], "mass": 44158.0, "length": 377, "protein_name": "tRNA-queuosine alpha-mannosyltransferase", "gene_name": "CG15914", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_573084", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573084", "type": "external" } ], "gene_names_uniprotkb": "CG15914", "gene_names_refseq": "CG15914; Dmel\\CG15914; PIG", "protein_names_uniprotkb": "tRNA-queuosine alpha-mannosyltransferase; 2.4.1.110", "protein_names_refseq": "CG15914-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15914)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Glycosyltransferase that specifically catalyzes mannosylation of cytoplasmic tRNA(Asp) modified with queuosine at position 34 (queuosine(34)). Mannosylates the cyclopentene moiety of queuosine(34) in tRNA(Asp) to form mannosyl-queuosine(34)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q29QR7", "ec_number_list": [ { "id": "2.4.1.110", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.110", "type": "external" } ], "go_molecular_function": "GO:0016438 tRNA-queuosine(34) beta-mannosyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006417 regulation of translation;GO:0006400 tRNA modification", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VXN0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VXN4-1", "uniprot_id": [ { "id": "SYRC_DROME", "url": "https://www.uniprot.org/uniprot/Q9VXN4", "type": "external" } ], "mass": 75577.0, "length": 665, "protein_name": "Probable arginine--tRNA ligase, cytoplasmic", "gene_name": "ArgRS", "organism": "Fruit fly", "refseq_name": "Arginyl-tRNA synthetase", "refseq_ac": [ { "id": "NP_573081", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573081", "type": "external" } ], "gene_names_uniprotkb": "ArgRS; Aats-arg; CG9020", "gene_names_refseq": "Aats-arg; ArgRS; CG9020; Dmel\\CG9020; RRS; dRARS", "protein_names_uniprotkb": "Probable arginine--tRNA ligase, cytoplasmic; 6.1.1.19; Arginyl-tRNA synthetase", "protein_names_refseq": "ArgRS-PA; Arginyl-tRNA ligase; Arginyl-tRNA synthetase; CG9020-PA; arginyl tRNA synthetase", "tax_id": 7227, "disease": "hypomyelinating leukodystrophy 9 (Disease Ontology:DOID:0060791)", "pathway": " (dme:Dmel_CG9020); (R-DME-9856649)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "6.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.4", "type": "external" }, { "id": "6.1.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.19", "type": "external" }, { "id": "6.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.6", "type": "external" }, { "id": "6.1.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.18", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004814 arginine-tRNA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0017101 aminoacyl-tRNA synthetase multienzyme complex", "go_biological_process": "GO:0006420 arginyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VXN4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VXP4-1", "uniprot_id": [ { "id": "PA1B2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VXP4", "type": "external" } ], "mass": 25461.0, "length": 225, "protein_name": "Platelet-activating factor acetylhydrolase IB subunit beta homolog", "gene_name": "Paf-AHalpha", "organism": "Fruit fly", "refseq_name": "Platelet-activating factor acetylhydrolase alpha, isoform B", "refseq_ac": [ { "id": "NP_525089", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_525089", "type": "external" } ], "gene_names_uniprotkb": "Paf-AHalpha; CG8962", "gene_names_refseq": "AAC83820; CG8962; Dmaalpha[[PAFAH]]; Dmel\\CG8962; PAFAHalpha; Paf-AHalpha; Paf-Aha", "protein_names_uniprotkb": "Platelet-activating factor acetylhydrolase IB subunit beta homolog", "protein_names_refseq": "CG8962-PB; Paf-AHalpha-PB; Platelet-activating factor acetylhydrolase alpha, isoform B; platelet-activating factor acetylhydrolase Ib alpha-subunit homolog; platelet-activating factor acetylhydrolase alpha subunit homolog", "tax_id": 7227, "disease": "lymphoma (Disease Ontology:DOID:0060058); status epilepticus (Disease Ontology:DOID:1824)", "pathway": " (dme:Dmel_CG8962); (R-DME-6798695); (R-DME-6811436)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10731132;10737922;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V4G6;O96644", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VXP4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VY28-1", "uniprot_id": [ { "id": "RT25_DROME", "url": "https://www.uniprot.org/uniprot/Q9VY28", "type": "external" } ], "mass": 19157.0, "length": 167, "protein_name": "Small ribosomal subunit protein mS25", "gene_name": "mRpS25", "organism": "Fruit fly", "refseq_name": "mitochondrial ribosomal protein S25", "refseq_ac": [ { "id": "NP_511153", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_511153", "type": "external" } ], "gene_names_uniprotkb": "mRpS25; CG14413", "gene_names_refseq": "25mRps; CG14413; Dmel\\CG14413; MRP-S25; MrpS25; mRpS25", "protein_names_uniprotkb": "Small ribosomal subunit protein mS25; 28S ribosomal protein S25, mitochondrial; MRP-S25; S25mt", "protein_names_refseq": "CG14413-PA; mRpS25-PA; mitochondrial ribosomal protein S25", "tax_id": 7227, "disease": "combined oxidative phosphorylation deficiency 50 (Disease Ontology:DOID:0112111)", "pathway": " (dme:Dmel_CG14413); (R-DME-5389840); (R-DME-5419276); (R-DME-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JQ26;Q29QE8", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VY28-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VYG1-1", "uniprot_id": [ { "id": "PSMD5_DROME", "url": "https://www.uniprot.org/uniprot/Q9VYG1", "type": "external" } ], "mass": 56668.0, "length": 506, "protein_name": "26S proteasome non-ATPase regulatory subunit 5", "gene_name": "S5b", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001285190", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285190", "type": "external" } ], "gene_names_uniprotkb": "S5b; 12096; CG12096; Dmel\\CG12096; Dmel_CG12096; PSMD5; dS5b", "gene_names_refseq": "12096; CG12096; Dmel\\CG12096; S5b/PSMD5; S5b; dS5b", "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 5; 26S proteasome subunit S5B; dS5b", "protein_names_refseq": "CG12096-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12096); (R-DME-9907900)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;23622245;25589440;26109356;26109357", "class_list": "", "function": "Acts as a chaperone during the assembly of the 26S proteasome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9UNC9;Q7K0M3;Q8SZZ0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0043248 proteasome assembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VYG1-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VYH3-1", "uniprot_id": [ { "id": "PEPE_DROME", "url": "https://www.uniprot.org/uniprot/Q9VYH3", "type": "external" } ], "mass": 26598.0, "length": 240, "protein_name": "Probable alpha-aspartyl dipeptidase", "gene_name": "Dmel\\CG2200", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001285183", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285183", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG2200; CG2200; Dmel_CG2200; FBgn0030447", "gene_names_refseq": "CG2200; Dmel\\CG2200; FBgn0030447", "protein_names_uniprotkb": "Probable alpha-aspartyl dipeptidase; 3.4.13.21; Asp-specific dipeptidase; Dipeptidase E", "protein_names_refseq": "CG2200-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2200)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Hydrolyzes dipeptides containing N-terminal aspartate residues., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q540X4", "ec_number_list": [], "go_molecular_function": "GO:0017171 serine hydrolase activity;GO:0008236 serine-type peptidase activity;GO:0016805 dipeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VYH3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VYI3-1", "uniprot_id": [ { "id": "RM49_DROME", "url": "https://www.uniprot.org/uniprot/Q9VYI3", "type": "external" } ], "mass": 20658.0, "length": 179, "protein_name": "Large ribosomal subunit protein mL49", "gene_name": "mRpL49", "organism": "Fruit fly", "refseq_name": "mitochondrial ribosomal protein L49, isoform B", "refseq_ac": [ { "id": "NP_001285170", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285170", "type": "external" } ], "gene_names_uniprotkb": "mRpL49; CG4647", "gene_names_refseq": "BcDNA:RE35556; CG4647; Dmel\\CG4647; MRP-L49; mRpL49; mRpl49", "protein_names_uniprotkb": "Large ribosomal subunit protein mL49; 39S ribosomal protein L49, mitochondrial; L49mt; MRP-L49", "protein_names_refseq": "CG4647-PB; mRpL49-PB; mitochondrial ribosomal protein L49, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4647); (R-DME-5389840); (R-DME-5419276); (R-DME-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003743 translation initiation factor activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VYI3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VYM3-1", "uniprot_id": [ { "id": "MKS1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VYM3", "type": "external" } ], "mass": 80084.0, "length": 699, "protein_name": "Tectonic-like complex member Mks1", "gene_name": "Mks1", "organism": "Fruit fly", "refseq_name": "meckel syndrome, type 1", "refseq_ac": [ { "id": "NP_572804", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572804", "type": "external" } ], "gene_names_uniprotkb": "Mks1; B9d3; CG15730", "gene_names_refseq": "CG15730; Dmel\\CG15730; MKS1; Mks1; dMks1; mks1", "protein_names_uniprotkb": "Tectonic-like complex member Mks1; Meckel syndrome type 1 protein homolog", "protein_names_refseq": "CG15730-PA; Mks1-PA; meckel syndrome, type 1 homologue; meckel syndrome, type 1", "tax_id": 7227, "disease": "atrioventricular septal defect (Disease Ontology:DOID:0050651); Meckel syndrome (Disease Ontology:DOID:0050778); ciliopathy (Disease Ontology:DOID:0060340); Meckel syndrome 1 (Disease Ontology:DOID:0070115); Bardet-Biedl syndrome 13 (Disease Ontology:DOID:0110135); Joubert syndrome 28 (Disease Ontology:DOID:0110997); Bardet-Biedl syndrome (Disease Ontology:DOID:1935); tetralogy of Fallot (Disease Ontology:DOID:6419)", "pathway": " (dme:Dmel_CG15730); (R-DME-5610787)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10731132;12537569;12537572;25447994;27577095;27646273;30013109", "class_list": "", "function": "Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia (PubMed:27577095, PubMed:27646273). Required for ciliary structure and function (PubMed:27577095)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8T8W8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005814 centriole;GO:0036038 MKS complex;GO:0035869 ciliary transition zone;GO:0061822 ciliary cap", "go_biological_process": "GO:0060271 cilium assembly;GO:1905515 non-motile cilium assembly;GO:0035082 axoneme assembly;GO:1905349 ciliary transition zone assembly;GO:1905350 Y-shaped link assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9VYM3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VYS5-1", "uniprot_id": [ { "id": "NDUF6_DROME", "url": "https://www.uniprot.org/uniprot/Q9VYS5", "type": "external" } ], "mass": 38175.0, "length": 334, "protein_name": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog", "gene_name": "sicily", "organism": "Fruit fly", "refseq_name": "severe impairment of CI with lengthened youth, isoform B", "refseq_ac": [ { "id": "NP_001285142", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285142", "type": "external" } ], "gene_names_uniprotkb": "sicily; CG15738", "gene_names_refseq": "CG15738; Dmel\\CG15738; Sicily; XE07; dNDUFAF6; sicily", "protein_names_uniprotkb": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog; Protein severe impairment of CI with lengthened youth; dNDUFAF6", "protein_names_refseq": "CG15738-PB; severe impairment of CI with lengthened youth, isoform B; sicily-PB", "tax_id": 7227, "disease": "Fanconi renotubular syndrome 5 (Disease Ontology:DOID:0080761); nuclear type mitochondrial complex I deficiency 17 (Disease Ontology:DOID:0112078); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (dme:Dmel_CG15738); (R-DME-6799198)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;23509070;34386730", "class_list": "", "function": "Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (Complex I) at early stages (PubMed:23509070). Interacts with cytosolic Hsp90 to chaperone the Complex I subunit ND-42 in the cytoplasm (PubMed:23509070)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "X2JJK8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VYS5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VYX7-1", "uniprot_id": [ { "id": "PGPSA_DROME", "url": "https://www.uniprot.org/uniprot/Q9VYX7", "type": "external" } ], "mass": 22260.0, "length": 203, "protein_name": "Peptidoglycan-recognition protein SA", "gene_name": "PGRP-SA", "organism": "Fruit fly", "refseq_name": "peptidoglycan recognition protein SA, isoform B", "refseq_ac": [ { "id": "NP_001285128", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285128", "type": "external" } ], "gene_names_uniprotkb": "PGRP-SA; BcDNA:AT30827; CG11709; Dm PGRP-SA; Dmel\\CG11709; Dmel_CG11709; SA; SEMMELWEIS; pgrp-sa; seml", "gene_names_refseq": "BcDNA:AT30827; CG11709; Dm PGRP-SA; Dmel\\CG11709; PGRP-SA; SA; SEMMELWEIS; pgrp-sa; seml", "protein_names_uniprotkb": "Peptidoglycan-recognition protein SA; 3.4.17.13; Protein semmelweis", "protein_names_refseq": "CG11709-PB; PG recognition Protein-SA; PGRP-SA-PB; Peptidoglycan-recognition protein-SA precursor; peptidoglycan recognition protein SA, isoform B; peptidoglycan recognition protein SA; peptidoglycan recognition protein-SA; protein semmelweis; semmelweiss", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11709); (R-DME-6798695); (R-DME-6803157)", "pathway_count": 3, "publication_count": 22, "publication_id_list": "10731132;11106397;11742401;12032070;12537568;12537569;12537572;12537573;12537574;14684822;14722090;14738318;15223330;15361936;15448690;16110336;16399077;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to peptidoglycans (PGN) of Gram-positive bacteria and activating the Toll pathway upstream of spz activating enzyme SPE (PubMed:11106397, PubMed:15448690, PubMed:16399077). Has no activity against Gram-negative bacteria and fungi (PubMed:11742401). Shows some partial redundancy with PRPGP-SD in Gram-positive bacteria recognition (PubMed:11742401, PubMed:15448690). May act by forming a complex with GNBP1 that activates the proteolytic cleavage of Spatzle and the subsequent activation of Toll pathway (PubMed:11742401, PubMed:14684822, PubMed:14722090). Binds to diaminopimelic acid-type tetrapeptide PGN (DAP-type PGN) and lysine-type PGN (Lys-type PGN) (PubMed:15361936). Has some L,D-carboxypeptidase activity for DAP-type PGN, which are specific to prokaryotes, but not for Lys-type PGN (PubMed:15361936)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.5.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.28", "type": "external" }, { "id": "3.2.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.14", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "3.4.17.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.13", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0042834 peptidoglycan binding;GO:0008270 zinc ion binding;GO:0038187 pattern recognition receptor activity;GO:0032500 muramyl dipeptide binding;GO:0016019 peptidoglycan immune receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0006955 immune response;GO:0045087 innate immune response;GO:0050830 defense response to Gram-positive bacterium;GO:0032494 response to peptidoglycan", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9VYX7-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VZ08-1", "uniprot_id": [ { "id": "GAPD1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VZ08", "type": "external" } ], "mass": 191221.0, "length": 1712, "protein_name": "GTPase-activating protein and VPS9 domain-containing protein 1", "gene_name": "Gapvd1", "organism": "Fruit fly", "refseq_name": "GTPase activating protein and VPS9 domains 1", "refseq_ac": [ { "id": "NP_572704", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572704", "type": "external" } ], "gene_names_uniprotkb": "Gapvd1; CG1657", "gene_names_refseq": "CG1657; Dmel\\CG1657; FBpp0073304; GAPVD1; Gapvd1", "protein_names_uniprotkb": "GTPase-activating protein and VPS9 domain-containing protein 1; Receptor-mediated endocytosis protein 6 homolog", "protein_names_refseq": "CG1657-PA; GTPase activating protein and VPS9 domains 1; Gapvd1-PA", "tax_id": 7227, "disease": "nephrotic syndrome (Disease Ontology:DOID:1184)", "pathway": " (dme:Dmel_CG1657); (R-DME-8856828); (R-DME-8876198)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;18327897;18535209;29959197", "class_list": "", "function": "Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in endocytosis (By similarity). Acts by regulating the activation of rab-5 by exchanging bound GDP for free GTP (By similarity). Involved in the trafficking of kirre/Nephrin during slit diaphragm formation in Garland cell nephrocytes (PubMed:29959197)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B4YWV1;Q95RG2", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding;GO:0032794 GTPase activating protein binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0016020 membrane;GO:0030139 endocytic vesicle", "go_biological_process": "GO:0032483 regulation of Rab protein signal transduction;GO:0051223 regulation of protein transport;GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VZ08-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VZ09-1", "uniprot_id": [ { "id": "SISA_DROME", "url": "https://www.uniprot.org/uniprot/Q9VZ09", "type": "external" } ], "mass": 21290.0, "length": 189, "protein_name": "Protein sisterless A", "gene_name": "sisA", "organism": "Fruit fly", "refseq_name": "sisterless A", "refseq_ac": [ { "id": "NP_511116", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_511116", "type": "external" } ], "gene_names_uniprotkb": "sisA; CG1641", "gene_names_refseq": "CG1641; DM29; Dmel\\CG1641; sis A; sis a; sis-A; sis-a; sisA; sisa", "protein_names_uniprotkb": "Protein sisterless A", "protein_names_refseq": "CG1641-PA; sisA-PA; sisterless A; sisterlessA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1641)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10731132;10790394;12537572;16083904;7651341;8370520;9671597", "class_list": "", "function": "Involved in sex determination and dosage compensation. Required for proper expression of Sxl in embryonic somatic cells. Also has an essential function in the yolk nuclei. Involved in endoderm migration and midgut formation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24525;Q4V6W9", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007530 sex determination;GO:0007497 posterior midgut development;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9VZ09-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VZ40-1", "uniprot_id": [ { "id": "Y1552_DROME", "url": "https://www.uniprot.org/uniprot/Q9VZ40", "type": "external" } ], "mass": 21452.0, "length": 184, "protein_name": "Uncharacterized protein CG1552", "gene_name": "anon-EST:Posey230", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform C", "refseq_ac": [ { "id": "NP_001285104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285104", "type": "external" } ], "gene_names_uniprotkb": "anon-EST:Posey230; CG1552; Dmel\\CG1552; Dmel_CG1552", "gene_names_refseq": "CG1552; Dmel\\CG1552; anon-EST:Posey230", "protein_names_uniprotkb": "Uncharacterized protein CG1552", "protein_names_refseq": "CG1552-PC; uncharacterized protein, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1552)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17018572;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IR96;Q95U12", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VZ40-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VZF4-1", "uniprot_id": [ { "id": "FBXW7_DROME", "url": "https://www.uniprot.org/uniprot/Q9VZF4", "type": "external" } ], "mass": 141361.0, "length": 1326, "protein_name": "F-box/WD repeat-containing protein 7", "gene_name": "ago", "organism": "Fruit fly", "refseq_name": "archipelago, isoform C", "refseq_ac": [ { "id": "NP_523922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523922", "type": "external" } ], "gene_names_uniprotkb": "ago; CG15010", "gene_names_refseq": "Ago; CG15010; DmFbw7; Dmel\\CG15010; FBXW3; FBXW7; SCF[Ago]; ago; anon-WO0118547.345; cdc4", "protein_names_uniprotkb": "F-box/WD repeat-containing protein 7; F-box and WD-40 domain-containing protein 7; Protein archipelago", "protein_names_refseq": "CG15010-PC; ago-PC; archipelago, isoform C; archipelago", "tax_id": 7227, "disease": "developmental delay, hypotonia, and impaired language (Disease Ontology:DOID:0070420)", "pathway": " (dme:Dmel_CG15010)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10731132;11565033;12537569;12537572;15175253;15182669;18327897;24173801;35395208", "class_list": "", "function": "Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Probably recognizes and binds to phosphorylated target proteins (By similarity). In the wing and eye, negatively regulates cell growth and proliferation by mediating the degradation of Myc and cyclin E, respectively (PubMed:11565033, PubMed:15182669). Required for endocycles, but not mitosis in follicle cell epithelium (PubMed:15175253)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4V1G6", "ec_number_list": [], "go_molecular_function": "GO:1990381 ubiquitin-specific protease binding;GO:0030332 cyclin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0071456 cellular response to hypoxia;GO:0030162 regulation of proteolysis;GO:0016567 protein ubiquitination;GO:0060253 negative regulation of glial cell proliferation;GO:0007096 regulation of exit from mitosis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9VZF4-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VZM5-1", "uniprot_id": [ { "id": "PIGB_DROME", "url": "https://www.uniprot.org/uniprot/Q9VZM5", "type": "external" } ], "mass": 65007.0, "length": 561, "protein_name": "GPI mannosyltransferase 3", "gene_name": "PIG-B", "organism": "Fruit fly", "refseq_name": "phosphatidylinositol glycan anchor biosynthesis class B, isoform A", "refseq_ac": [ { "id": "NP_647832", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647832", "type": "external" } ], "gene_names_uniprotkb": "PIG-B; CG12006", "gene_names_refseq": "CG12006; DmPIG-B; Dmel\\CG12006; PIG-B; PIGB", "protein_names_uniprotkb": "GPI mannosyltransferase 3; 2.4.1.-; GPI mannosyltransferase III; GPI-MT-III; Phosphatidylinositol-glycan biosynthesis class B protein", "protein_names_refseq": "CG12006-PA; PIG-B-PA; phosphatidylinositol glycan anchor biosynthesis class B, isoform A", "tax_id": 7227, "disease": "developmental and epileptic encephalopathy 80 (Disease Ontology:DOID:0112216); sleeping sickness (Disease Ontology:DOID:10112)", "pathway": " (dme:Dmel_CG12006); (R-DME-162710)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "glycogene;glycosyltransferase", "function": "Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q7KV63", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0000026 alpha-1,2-mannosyltransferase activity;GO:0120564 dol-P-Man:Man(2)GlcN-acyl-PI alpha-1,2-mannosyltransferase activity", "go_cellular_component": "GO:0031965 nuclear membrane", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VZM5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VZS5-1", "uniprot_id": [ { "id": "RL28_DROME", "url": "https://www.uniprot.org/uniprot/Q9VZS5", "type": "external" } ], "mass": 16029.0, "length": 144, "protein_name": "Large ribosomal subunit protein eL28", "gene_name": "RpL28", "organism": "Fruit fly", "refseq_name": "ribosomal protein L28, isoform E", "refseq_ac": [ { "id": "NP_001163336", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163336", "type": "external" } ], "gene_names_uniprotkb": "RpL28; CG12740", "gene_names_refseq": "BcDNA:GH04183; CG12740; Dmel\\CG12740; GH04183p; L28e; L28; RpL28; Rpl28; anon-WO0118547.321; chr3L:3205394..3205484", "protein_names_uniprotkb": "Large ribosomal subunit protein eL28; 60S ribosomal protein L28", "protein_names_refseq": "60 S ribosomal protein L28; CG12740-PE; RpL28-PE; ribosomal protein L28, isoform E", "tax_id": 7227, "disease": "middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (dme:Dmel_CG12740); (R-DME-156827); (R-DME-1799339); (R-DME-72689); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954709); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 10, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;23636399", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V1E2;Q0E8I7", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022626 cytosolic ribosome;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VZS5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VZX9-1", "uniprot_id": [ { "id": "SAHH2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VZX9", "type": "external" } ], "mass": 56978.0, "length": 521, "protein_name": "Adenosylhomocysteinase-like 1", "gene_name": "AhcyL1", "organism": "Fruit fly", "refseq_name": "adenosylhomocysteinase like 1", "refseq_ac": [ { "id": "NP_647746", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647746", "type": "external" } ], "gene_names_uniprotkb": "AhcyL1; CG9977", "gene_names_refseq": "AhcyL1; CG9977; Dmel\\CG9977; IRBIT; dAhcyL1", "protein_names_uniprotkb": "Adenosylhomocysteinase-like 1; Inactive S-adenosyl-L-homocysteine hydrolase; S-adenosylhomocysteine hydrolase-like protein 1; dAhcyL1", "protein_names_refseq": "AhcyL1-PA; CG9977-PA; adenosylhomocysteinase like 1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9977); (R-DME-425381); (R-DME-5578775)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10731132;12537572;27313316;40971386", "class_list": "", "function": "Might play a role in the regulation of methionine metabolism possibly by binding and inactivating Ahcy., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NR07", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006730 one-carbon metabolic process;GO:0033353 S-adenosylmethionine cycle", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VZX9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W040-1", "uniprot_id": [ { "id": "OSM1_DROME", "url": "https://www.uniprot.org/uniprot/Q9W040", "type": "external" } ], "mass": 195708.0, "length": 1754, "protein_name": "Intraflagellar transport protein 172 homolog", "gene_name": "Oseg2", "organism": "Fruit fly", "refseq_name": "outer segment 2", "refseq_ac": [ { "id": "NP_647700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647700", "type": "external" } ], "gene_names_uniprotkb": "Oseg2; CG13809; osm-1", "gene_names_refseq": "CG13809; Dmel\\CG13809; IFT172; OSEG2; OSEG; OSM-1; Oseg2; oseg2; osm-1", "protein_names_uniprotkb": "Intraflagellar transport protein 172 homolog; Osmotic avoidance abnormal protein 1 homolog; Outer segment 2", "protein_names_refseq": "CG13809-PB; Oseg2-PB; osm-1; outer segment 2; selective LIM binding factor", "tax_id": 7227, "disease": "atrioventricular septal defect (Disease Ontology:DOID:0050651); polycystic kidney disease (Disease Ontology:DOID:0080322); Bardet-Biedl syndrome 20 (Disease Ontology:DOID:0081009); short-rib thoracic dysplasia 10 with or without polydactyly (Disease Ontology:DOID:0110091); retinitis pigmentosa 71 (Disease Ontology:DOID:0110363); VACTERL association (Disease Ontology:DOID:14679); cystic kidney disease (Disease Ontology:DOID:2975); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (dme:Dmel_CG13809); (R-DME-5610787)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Required for the maintenance and formation of cilia., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0005930 axoneme;GO:0097730 non-motile cilium;GO:0036064 ciliary basal body;GO:0030990 intraciliary transport particle", "go_biological_process": "GO:0060271 cilium assembly;GO:1905515 non-motile cilium assembly;GO:0042073 intraciliary transport;GO:0035721 intraciliary retrograde transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9W040-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W0P2-1", "uniprot_id": [ { "id": "REV1_DROME", "url": "https://www.uniprot.org/uniprot/Q9W0P2", "type": "external" } ], "mass": 112414.0, "length": 995, "protein_name": "DNA repair protein Rev1", "gene_name": "Rev1", "organism": "Fruit fly", "refseq_name": "DNA polymerase Rev1", "refseq_ac": [ { "id": "NP_612047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612047", "type": "external" } ], "gene_names_uniprotkb": "Rev1; CG12189", "gene_names_refseq": "AAF47401; CG12189; DmREV1; DmRev1; Dmel\\CG12189; REV1; Rev1; dREV1; dRev1; drev1; rev1", "protein_names_uniprotkb": "DNA repair protein Rev1; 2.7.7.-; Reversionless protein 1", "protein_names_refseq": "CG12189-PA; DNA polymerase Rev1; Rev1 DNA directed polymerase; Rev1-PA; UV-revertible gene 1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12189); (R-DME-110312); (R-DME-5655862); (R-DME-5656121); (R-DME-5656169)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "10731132;11297519;12537569;12537572;18242152;22532806", "class_list": "", "function": "Deoxycytidyl transferase involved in DNA repair (PubMed:22532806). Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents (By similarity). During homologous recombination (HR) repair of DNA double-strand breaks (DSBs) regulates the extent of repair synthesis (PubMed:22532806). Possibly recruits the DNA polymerase zeta complex or another translesion polymerase to early DSB repair intermediates to initiate repair synthesis, while also blocking the access of more processive polymerases preventing them from acting during the initial stages of HR repair (PubMed:22532806)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9UNE7;Q8T9I8", "ec_number_list": [ { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0060090 molecular adaptor activity;GO:0046872 metal ion binding;GO:0003684 damaged DNA binding;GO:0017125 deoxycytidyl transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0035861 site of double-strand break;GO:0005657 replication fork", "go_biological_process": "GO:0006302 double-strand break repair;GO:0019985 translesion synthesis;GO:0042276 error-prone translesion synthesis;GO:0010569 regulation of double-strand break repair via homologous recombination;GO:0070987 error-free translesion synthesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9W0P2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W0S7-1", "uniprot_id": [ { "id": "SND1_DROME", "url": "https://www.uniprot.org/uniprot/Q9W0S7", "type": "external" } ], "mass": 103100.0, "length": 926, "protein_name": "Staphylococcal nuclease domain-containing protein 1", "gene_name": "Tudor-SN", "organism": "Fruit fly", "refseq_name": "tudor staphylococcal nuclease, isoform B", "refseq_ac": [ { "id": "NP_001261195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261195", "type": "external" } ], "gene_names_uniprotkb": "Tudor-SN; CG7008; SND1; TSN; p100", "gene_names_refseq": "CG7008; Dmel\\CG7008; SND1; TSN-1; TSN; TUDOR-SN; Tsn; Tudor-SN; dP100; p100; tudor-SN", "protein_names_uniprotkb": "Staphylococcal nuclease domain-containing protein 1; 3.1.31.1; Tudor staphylococcal nuclease", "protein_names_refseq": "CG7008-PB; Tudor-SN-PB; tudor staphylococcal nuclease, isoform B; tudor staphylococcal nuclease", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7008)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;14508492;19232356;26808625", "class_list": "", "function": "Endonuclease which shows activity towards both DNA and RNA substrates (PubMed:14508492, PubMed:26808625). Has a role in translation regulation throught its association with the with the RNA-induced silencing complex (RISC) (PubMed:14508492, PubMed:26808625). Plays a role in spermatogenesis probably by negatively regulating piwi expression in the germline (PubMed:26808625). Together with piwi, might be involved in transposon repression in the germline (PubMed:26808625)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8T0F1", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0004521 RNA endonuclease activity;GO:0004518 nuclease activity;GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016442 RISC complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0006402 mRNA catabolic process;GO:0031047 regulatory ncRNA-mediated gene silencing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9W0S7-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W0T5-1", "uniprot_id": [ { "id": "PYX_DROME", "url": "https://www.uniprot.org/uniprot/Q9W0T5", "type": "external" } ], "mass": 107920.0, "length": 956, "protein_name": "Transient receptor potential channel pyrexia", "gene_name": "pyx", "organism": "Fruit fly", "refseq_name": "pyrexia, isoform A", "refseq_ac": [ { "id": "NP_612015", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612015", "type": "external" } ], "gene_names_uniprotkb": "pyx; CG17142", "gene_names_refseq": "CG17142; CT33412; Dmel\\CG17142; Pyrexia; Pyx; dTRPA2; pyrx; pyx; trpA2", "protein_names_uniprotkb": "Transient receptor potential channel pyrexia", "protein_names_refseq": "CG17142-PA; pyrexia, isoform A; pyrexia; pyx-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17142)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;15731759", "class_list": "", "function": "Receptor-activated non-selective cation channel involved in protection or tolerance from high temperature stress. Activated by temperatures above 40 degrees Celsius. More permeable to K(+) than to Na(+). May act in stress protection allow flies to survive in natural environments., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8I0I4", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005261 monoatomic cation channel activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0016020 membrane", "go_biological_process": "GO:0006816 calcium ion transport;GO:0006812 monoatomic cation transport;GO:0006813 potassium ion transport;GO:0009408 response to heat;GO:0048060 negative gravitaxis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9W0T5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W138-1", "uniprot_id": [ { "id": "SAMTR_DROME", "url": "https://www.uniprot.org/uniprot/Q9W138", "type": "external" } ], "mass": 34819.0, "length": 302, "protein_name": "Probable S-adenosyl-L-methionine-dependent methyltransferase", "gene_name": "CG3570", "organism": "Fruit fly", "refseq_name": "S-adenosylmethionine sensor upstream of TORC1", "refseq_ac": [ { "id": "NP_611943", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611943", "type": "external" } ], "gene_names_uniprotkb": "CG3570", "gene_names_refseq": "CG3570; Dmel\\CG3570; SAMTOR; Samtor; dSAMTOR; dSamtor; samtor", "protein_names_uniprotkb": "Probable S-adenosyl-L-methionine-dependent methyltransferase; 2.1.1.-; S-adenosylmethionine sensor upstream of mTORC1; dSamtor", "protein_names_refseq": "CG3570-PA; S-adenosylmethionine sensor upstream of TORC1; S-adenosylmethionine sensor upstream of mTORC1; Samtor-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3570)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;29123071;35776786;38514639", "class_list": "", "function": "S-adenosyl-L-methionine-binding protein (PubMed:29123071, PubMed:35776786). It is unclear whether this protein acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1 (PubMed:29123071, PubMed:35776786, PubMed:38514639). Probably acts as a S-adenosyl-L-methionine-dependent methyltransferase., [UniProtKB, HAMAP, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008168 methyltransferase activity", "go_cellular_component": "", "go_biological_process": "GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9W138-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W1C9-1", "uniprot_id": [ { "id": "PEB3_DROME", "url": "https://www.uniprot.org/uniprot/Q9W1C9", "type": "external" } ], "mass": 14540.0, "length": 126, "protein_name": "Ejaculatory bulb-specific protein 3", "gene_name": "EbpIII", "organism": "Fruit fly", "refseq_name": "ejaculatory bulb protein III, isoform B", "refseq_ac": [ { "id": "NP_001286808", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286808", "type": "external" } ], "gene_names_uniprotkb": "EbpIII; CG11390; PebIII", "gene_names_refseq": "BcDNA:RH74005; CG11390; DmelCSP2; Dmel\\CG11390; EbpIII; PEBmeIII; PEBmelIII; PEB; PebIII; Phk-2; phk-2", "protein_names_uniprotkb": "Ejaculatory bulb-specific protein 3; Ejaculatory bulb-specific protein III; PEB-meIII; PEBmelIII", "protein_names_refseq": "CG11390-PB; EbpIII-PB; ejaculatory bulb III; ejaculatory bulb protein III, isoform B; pherokine 2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11390)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;16581978;7619487", "class_list": "", "function": "Protein component of the posterior mating plug., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q23981;Q3LB28", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0009615 response to virus;GO:0042628 mating plug formation;GO:0007552 metamorphosis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9W1C9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W1G0-1", "uniprot_id": [ { "id": "TALDO_DROME", "url": "https://www.uniprot.org/uniprot/Q9W1G0", "type": "external" } ], "mass": 36734.0, "length": 331, "protein_name": "Probable transaldolase", "gene_name": "Taldo", "organism": "Fruit fly", "refseq_name": "transaldolase", "refseq_ac": [ { "id": "NP_523835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523835", "type": "external" } ], "gene_names_uniprotkb": "Taldo; CG2827; Tal", "gene_names_refseq": "154176_at; CG2827; CT9666; Dmel\\CG2827; TA; Taldo; Tal; tal", "protein_names_uniprotkb": "Probable transaldolase; 2.2.1.2", "protein_names_refseq": "CG2827-PA; Taldo-PA; transaldolase", "tax_id": 7227, "disease": "carbohydrate metabolic disorder (Disease Ontology:DOID:2978)", "pathway": " (dme:Dmel_CG2827); (R-DME-163754); (R-DME-71336)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Transaldolase involved in the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedoheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate. Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.2.1.2", "type": "external" } ], "go_molecular_function": "GO:0004801 transaldolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0009052 pentose-phosphate shunt, non-oxidative branch;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9W1G0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W1V6-1", "uniprot_id": [ { "id": "PPO3_DROME", "url": "https://www.uniprot.org/uniprot/Q9W1V6", "type": "external" } ], "mass": 79314.0, "length": 683, "protein_name": "Phenoloxidase 3", "gene_name": "PPO3", "organism": "Fruit fly", "refseq_name": "prophenoloxidase 3", "refseq_ac": [ { "id": "NP_524760", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524760", "type": "external" } ], "gene_names_uniprotkb": "PPO3; CG42640; Dox-3; Dox-A3; proPO59", "gene_names_refseq": "CG2952; CG42640; DmePPO3; Dmel\\CG42640; Dox-A3; PPO3; PPO; Pro-PO3; ProPO59; proPO59", "protein_names_uniprotkb": "Phenoloxidase 3; 1.14.18.1; Diphenol oxidase A3; Diphenoloxidase subunit A3; Prophenoloxidase 59; Tyrosinase A3", "protein_names_refseq": "CG42640-PA; PPO3-PA; diphenol OxidaseA3; prophenoloxidase 3; prophenoloxidase 59", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG42640)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;12834045;19141111", "class_list": "", "function": "This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6 dihydroxyindole to indole-5'6 quinone (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q95R43;Q9BLD9", "ec_number_list": [ { "id": "1.14.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.18.1", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004503 tyrosinase activity;GO:0004097 catechol oxidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm", "go_biological_process": "GO:0042417 dopamine metabolic process;GO:0042438 melanin biosynthetic process;GO:0035011 melanotic encapsulation of foreign target", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9W1V6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W261-1", "uniprot_id": [ { "id": "RTF1_DROME", "url": "https://www.uniprot.org/uniprot/Q9W261", "type": "external" } ], "mass": 87552.0, "length": 775, "protein_name": "RNA polymerase-associated protein Rtf1", "gene_name": "Rtf1", "organism": "Fruit fly", "refseq_name": "Rtf1, isoform B", "refseq_ac": [ { "id": "NP_001286717", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286717", "type": "external" } ], "gene_names_uniprotkb": "Rtf1; CG10955", "gene_names_refseq": "CG10955; Dmel\\CG10955; Rtf1; dRtf1; rtf1", "protein_names_uniprotkb": "RNA polymerase-associated protein Rtf1; dRtf1", "protein_names_refseq": "CG10955-PB; Rtf1, isoform B; Rtf1-PB", "tax_id": 7227, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (dme:Dmel_CG10955)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537572;16354696;16882721;18327897", "class_list": "", "function": "Plays a role in transcription-coupled histone modification. Required for methylation of 'Lys-4' of histone H3. Plays a role in regulation of transcription. Required for maximal induction of heat-shock genes. Plays a role in Notch signaling in the wing margins., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0000791 euchromatin;GO:0016593 Cdc73/Paf1 complex", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9W261-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W278-1", "uniprot_id": [ { "id": "MED16_DROME", "url": "https://www.uniprot.org/uniprot/Q9W278", "type": "external" } ], "mass": 89979.0, "length": 818, "protein_name": "Mediator of RNA polymerase II transcription subunit 16", "gene_name": "MED16", "organism": "Fruit fly", "refseq_name": "mediator complex subunit 16", "refseq_ac": [ { "id": "NP_611650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611650", "type": "external" } ], "gene_names_uniprotkb": "MED16; CG5465; Trap95", "gene_names_refseq": "CG5465; Dmel\\CG5465; MED16; Med16; Sin4/TRAP95; Trap95; dTRAP95; med16", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 16; Mediator complex subunit 16", "protein_names_refseq": "CG5465-PA; MED16-PA; mediator complex subunit 16", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5465); (R-DME-9841922)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;15297616;16751183", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA, MtnB and MtnD genes. Required for transcriptional activation in response to lipopolysacchardie (LPS)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MT57;Q9GYW8", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016592 mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0032496 response to lipopolysaccharide;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9W278-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W2D6-1", "uniprot_id": [ { "id": "TIM10_DROME", "url": "https://www.uniprot.org/uniprot/Q9W2D6", "type": "external" } ], "mass": 10578.0, "length": 92, "protein_name": "Mitochondrial import inner membrane translocase subunit Tim10", "gene_name": "Tim10", "organism": "Fruit fly", "refseq_name": "translocase of inner membrane 10, isoform A", "refseq_ac": [ { "id": "NP_611606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611606", "type": "external" } ], "gene_names_uniprotkb": "Tim10; CG9878", "gene_names_refseq": "CG9878; Dmel\\CG9878; Dromel_CG9878_FBtr0071676_tim10_mORF; Tim10; bs31d12.y1; tim10", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit Tim10", "protein_names_refseq": "CG9878-PA; Tim10-PA; translocase of inner membrane 10, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9878); (R-DME-1268020)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10611480;10731132;12537569;12537572", "class_list": "", "function": "Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7YZS2;Q0E8Z5;Q9Y0V7", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0032977 membrane insertase activity", "go_cellular_component": "GO:0042719 mitochondrial intermembrane space chaperone complex;GO:0042721 TIM22 mitochondrial import inner membrane insertion complex", "go_biological_process": "GO:0015031 protein transport;GO:0045039 protein insertion into mitochondrial inner membrane;GO:0050829 defense response to Gram-negative bacterium;GO:0045824 negative regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9W2D6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W2E7-1", "uniprot_id": [ { "id": "RAE1_DROME", "url": "https://www.uniprot.org/uniprot/Q9W2E7", "type": "external" } ], "mass": 38618.0, "length": 346, "protein_name": "Protein Rae1", "gene_name": "Rae1", "organism": "Fruit fly", "refseq_name": "Rae1", "refseq_ac": [ { "id": "NP_611597", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611597", "type": "external" } ], "gene_names_uniprotkb": "Rae1; CG9862", "gene_names_refseq": "CG9862; DRae1; Dmel\\CG9862; EN2-8; Rae1; dmrae1; rae1", "protein_names_uniprotkb": "Protein Rae1", "protein_names_refseq": "CG9862-PA; Rae1-PA; Rae1; enhancer of NA9 2-8", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9862); (R-DME-159227); (R-DME-159230); (R-DME-159231); (R-DME-159236); (R-DME-1855170); (R-DME-1855196); (R-DME-1855229); (R-DME-3108214); (R-DME-3301854); (R-DME-3371453); (R-DME-4085377); (R-DME-4551638); (R-DME-4615885)", "pathway_count": 14, "publication_count": 8, "publication_id_list": "10731132;12537572;14729268;21874015;23788425;27494403;28554770;28604694", "class_list": "", "function": "Probable component of the nuclear pore complex (NPC) which regulates the nuclear export of specific mRNAs and promotes cell cycle progression during mitosis and male meiosis (PubMed:14729268, PubMed:23788425, PubMed:27494403). Acts with Nup98-96 to promote the nuclear export of specific mRNAs such as Moe, however it does not appear to be required for general nuclear mRNA transport (PubMed:14729268, PubMed:28554770). Essential mitotic and male meiotic cell cycle regulator with roles in many aspects of the cell cycle including chromatin organization and condensation, spindle assembly, chromosome segregation, and maintaining nuclear structure (PubMed:14729268, PubMed:23788425, PubMed:27494403). During male meiosis it is required for completion of meiosis I, as well as accurate cytokinesis of the secondary spermatocytes, and postmeiotic differentiation of spermatids (PubMed:23788425). Acts as a downstream regulatory target of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway to promote mitotic cell cycle progression and proliferation during wing and eye development, and thereby plays a key role in integrating the regulation of proliferation with organ size control (PubMed:14729268, PubMed:27494403). When the Hippo/SWH signaling pathway is inactive, Rae1 acts independently of yki to increase organ size by promoting mitotic S-phase entry and increase cellular proliferation (PubMed:27494403). When the Hippo/SWH signaling pathway is active it inhibits the activity of Rae1 in a Wts-dependent manner to restrict organ growth (PubMed:27494403). However, Rae1 is also able to negatively regulate the levels and activity of yki likely by activating the core kinases of the Hippo/SWH signaling pathway hpo and Wts and increasing the protein levels of hpo, Mer and Wts; it is therefore likely that it functions as part of a negative feedback loop with the Hippo/SWH signaling pathway to regulate pathway homeostasis and prevent organ overgrowth (PubMed:27494403). Promotes mitotic cell cycle progression, at least in part, by increasing the accumulation of mitotic cyclins such as CycB, possibly by directly up-regulating cyclin transcripts or by inhibiting the anaphase promoting complex/cyclosome (APC/C) activator fzy (PubMed:27494403). Also required in presynaptic, postmitotic motor neurons to restrain synaptic terminal growth (PubMed:21874015). Promotes the expression and stability of the an E3 ubiquitin ligase of hiw, and is likely to function in the regulation of synaptic growth by binding to hiw and protecting it from autophagy-mediated degradation (PubMed:21874015)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7JVX4", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0035330 regulation of hippo signaling;GO:0000278 mitotic cell cycle;GO:0006913 nucleocytoplasmic transport;GO:0007283 spermatogenesis;GO:0010506 regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W2E7-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W2Q1-1", "uniprot_id": [ { "id": "RX_DROME", "url": "https://www.uniprot.org/uniprot/Q9W2Q1", "type": "external" } ], "mass": 92897.0, "length": 873, "protein_name": "Retinal homeobox protein Rx", "gene_name": "Rx", "organism": "Fruit fly", "refseq_name": "retinal homeobox", "refseq_ac": [ { "id": "NP_726006", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_726006", "type": "external" } ], "gene_names_uniprotkb": "Rx; CG10052", "gene_names_refseq": "CG10052; DRx; Dmel\\CG10052; Drx; E97; PPH17; Rx; W60; bk50; drx; rx; wom", "protein_names_uniprotkb": "Retinal homeobox protein Rx; DRx1; DRx", "protein_names_refseq": "CG10052-PB; Rx-PB; drosophila Rx; retinal homeobox; wombat", "tax_id": 7227, "disease": "syndromic microphthalmia 16 (Disease Ontology:DOID:0060842); retinitis pigmentosa 95 (Disease Ontology:DOID:0061112); age related macular degeneration 6 (Disease Ontology:DOID:0110018); cone-rod dystrophy 11 (Disease Ontology:DOID:0111018)", "pathway": " (dme:Dmel_CG10052)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;9177348;9482887", "class_list": "", "function": "Appears to function in brain development., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O46035", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9W2Q1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W334-1", "uniprot_id": [ { "id": "RS28_DROME", "url": "https://www.uniprot.org/uniprot/Q9W334", "type": "external" } ], "mass": 7477.0, "length": 65, "protein_name": "Small ribosomal subunit protein eS28", "gene_name": "RpS28b", "organism": "Fruit fly", "refseq_name": "ribosomal protein S28b, isoform B", "refseq_ac": [ { "id": "NP_001285059", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285059", "type": "external" } ], "gene_names_uniprotkb": "RpS28b; CG2998; Dmel\\CG2998; Dmel_CG2998; RS28_DROME; RpS28; S28e", "gene_names_refseq": "CG2998; Dmel\\CG2998; RS28_DROME; RpS28b; RpS28; S28e", "protein_names_uniprotkb": "Small ribosomal subunit protein eS28; 40S ribosomal protein S28", "protein_names_refseq": "CG2998-PB; RpS28b-PB; ribosomal protein S28b, isoform B", "tax_id": 7227, "disease": "Diamond-Blackfan anemia 15 with mandibulofacial dysostosis (Disease Ontology:DOID:0111894)", "pathway": " (dme:Dmel_CG2998); (R-DME-156827); (R-DME-1799339); (R-DME-6791226); (R-DME-72649); (R-DME-72689); (R-DME-72695); (R-DME-72702); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 13, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;23636399;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022626 cytosolic ribosome;GO:0022627 cytosolic small ribosomal subunit;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0030490 maturation of SSU-rRNA;GO:0000028 ribosomal small subunit assembly;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9W334-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W376-1", "uniprot_id": [ { "id": "NEUFC_DROME", "url": "https://www.uniprot.org/uniprot/Q9W376", "type": "external" } ], "mass": 32628.0, "length": 287, "protein_name": "Neuferricin homolog", "gene_name": "CG12056", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_572535", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572535", "type": "external" } ], "gene_names_uniprotkb": "CG12056", "gene_names_refseq": "CG12056; Dmel\\CG12056", "protein_names_uniprotkb": "Neuferricin homolog; Cytochrome b5 domain-containing protein 2 homolog", "protein_names_refseq": "CG12056-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12056)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Heme-binding protein., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9W376-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W385-1", "uniprot_id": [ { "id": "FRDA_DROME", "url": "https://www.uniprot.org/uniprot/Q9W385", "type": "external" } ], "mass": 20922.0, "length": 190, "protein_name": "Frataxin homolog, mitochondrial", "gene_name": "fh", "organism": "Fruit fly", "refseq_name": "frataxin", "refseq_ac": [ { "id": "NP_511094", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_511094", "type": "external" } ], "gene_names_uniprotkb": "fh; CG8971", "gene_names_refseq": "BcDNA:AT09528; CG8971; DFH; Dfh; Dmel\\CG8971; Fh; X25; dfh; fh", "protein_names_uniprotkb": "Frataxin homolog, mitochondrial; 1.16.3.1; Dfh", "protein_names_refseq": "CG8971-PA; drosophila frataxin homolog; fh-PA; frataxin homologue; frataxin-like; frataxin", "tax_id": 7227, "disease": "Friedreich ataxia 1 (Disease Ontology:DOID:0111218); Friedreich ataxia (Disease Ontology:DOID:12705); cancer (Disease Ontology:DOID:162); iron metabolism disease (Disease Ontology:DOID:2351); glioblastoma (Disease Ontology:DOID:3068); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dme:Dmel_CG8971); (R-DME-1362409); (R-DME-9854311); (R-DME-9865881)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "10731132;11054533;12537569;12537572;18540637;25628335;29491838;36601804", "class_list": "", "function": "Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways (PubMed:18540637). May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+) (PubMed:18540637). May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization (PubMed:18540637). Required for ecdysteroidogenesis in the prothoracic gland which is necessary for larval to pupal transition (PubMed:25628335)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9GQQ7", "ec_number_list": [ { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "2.8.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.1.7", "type": "external" }, { "id": "7.1.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.8", "type": "external" } ], "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0008198 ferrous iron binding;GO:0004322 ferroxidase activity;GO:0034986 iron chaperone activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:1904115 axon cytoplasm;GO:0099128 mitochondrial [2Fe-2S] assembly complex", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0006979 response to oxidative stress;GO:0008344 adult locomotory behavior;GO:0006879 intracellular iron ion homeostasis;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9W385-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W3H5-1", "uniprot_id": [ { "id": "Q9W3H5_DROME", "url": "https://www.uniprot.org/uniprot/Q9W3H5", "type": "external" } ], "mass": 17157.0, "length": 165, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG2147", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_572465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572465", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG2147; BcDNA:LP02728; CG2147; Dmel_CG2147", "gene_names_refseq": "BcDNA:LP02728; CG2147; Dmel\\CG2147", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG2147-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2147)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W3H5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W3U1-1", "uniprot_id": [ { "id": "SETD3_DROME", "url": "https://www.uniprot.org/uniprot/Q9W3U1", "type": "external" } ], "mass": 61158.0, "length": 537, "protein_name": "Actin-histidine N-methyltransferase", "gene_name": "Setd3", "organism": "Fruit fly", "refseq_name": "SET domain containing 3", "refseq_ac": [ { "id": "NP_727144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_727144", "type": "external" } ], "gene_names_uniprotkb": "Setd3; CG32732", "gene_names_refseq": "CG12542; CG3042; CG32732; Dmel\\CG32732; SETD3; Setd3; dSETD3", "protein_names_uniprotkb": "Actin-histidine N-methyltransferase; 2.1.1.85; Protein-L-histidine N-tele-methyltransferase; SET domain-containing protein 3 homolog", "protein_names_refseq": "CG32732-PA; SET domain containing 3; Setd3-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32732)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;30067821;30526847", "class_list": "", "function": "Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-74'., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.85", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003779 actin binding;GO:0042800 histone H3K4 methyltransferase activity;GO:0046975 histone H3K36 methyltransferase activity;GO:0018064 protein-L-histidine N-tele-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030047 actin modification;GO:0018021 peptidyl-histidine methylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9W3U1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W3W8-1", "uniprot_id": [ { "id": "RL17_DROME", "url": "https://www.uniprot.org/uniprot/Q9W3W8", "type": "external" } ], "mass": 21593.0, "length": 186, "protein_name": "Large ribosomal subunit protein uL22", "gene_name": "RpL17", "organism": "Fruit fly", "refseq_name": "ribosomal protein L17, isoform E", "refseq_ac": [ { "id": "NP_001284961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284961", "type": "external" } ], "gene_names_uniprotkb": "RpL17; CG3203; Dmel\\CG3203; Dmel_CG3203; L22; Rpl17; anon-EST:Posey276", "gene_names_refseq": "CG3203; Dmel\\CG3203; L22; RpL17; Rpl17; anon-EST:Posey276", "protein_names_uniprotkb": "Large ribosomal subunit protein uL22; 60S ribosomal protein L17", "protein_names_refseq": "CG3203-PE; RpL17-PE; ribosomal protein L17, isoform E; ribosomal protein L17", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3203); (R-DME-156827); (R-DME-1799339); (R-DME-72689); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954709); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 10, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;18327897;23636399;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022626 cytosolic ribosome;GO:0022625 cytosolic large ribosomal subunit;GO:0015934 large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9W3W8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W420-1", "uniprot_id": [ { "id": "SPT6H_DROME", "url": "https://www.uniprot.org/uniprot/Q9W420", "type": "external" } ], "mass": 208599.0, "length": 1831, "protein_name": "Transcription elongation factor SPT6", "gene_name": "Spt6", "organism": "Fruit fly", "refseq_name": "Spt6, isoform B", "refseq_ac": [ { "id": "NP_001284936", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284936", "type": "external" } ], "gene_names_uniprotkb": "Spt6; CG12225", "gene_names_refseq": "CG12225; Dmel\\CG12225; Dspt6; SPT6; Spt6; dSpt6; dspt6; l(1)G0063; spt 6; spt6", "protein_names_uniprotkb": "Transcription elongation factor SPT6", "protein_names_refseq": "CG12225-PB; Spt6, isoform B; Spt6-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12225); (R-DME-112382); (R-DME-674695); (R-DME-75955)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "10731132;11040216;11040217;12490954;12537569;12537572;12934007;17372656;18327897;19279664", "class_list": "", "function": "Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation. Required for the transcriptional induction of heat shock response genes and for maximal recruitment of two other elongation factors, Spt5 and Paf1, to the induced Hsp70. Plays a critical role in normal fly development throughout the lifecycle., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q960J2;Q9U8B5;Q9U8B6", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0042393 histone binding;GO:0000993 RNA polymerase II complex binding;GO:0031491 nucleosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0008023 transcription elongation factor complex;GO:0000775 chromosome, centromeric region;GO:0000791 euchromatin;GO:0035363 histone locus body", "go_biological_process": "GO:0034728 nucleosome organization;GO:0006368 transcription elongation by RNA polymerase II;GO:0006963 positive regulation of antibacterial peptide biosynthetic process;GO:0030707 follicle cell of egg chamber development;GO:0140673 transcription elongation-coupled chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9W420-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W436-1", "uniprot_id": [ { "id": "NEP_DROME", "url": "https://www.uniprot.org/uniprot/Q9W436", "type": "external" } ], "mass": 96534.0, "length": 849, "protein_name": "Neprilysin-1", "gene_name": "Nep1", "organism": "Fruit fly", "refseq_name": "neprilysin 1, isoform C", "refseq_ac": [ { "id": "NP_001284925", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284925", "type": "external" } ], "gene_names_uniprotkb": "Nep1; CG5905", "gene_names_refseq": "CG5894; CG5905; CG5914; DmeNEP1; Dmel\\CG5905; NEP1; NEP; Nep1; dNEP1; nep1", "protein_names_uniprotkb": "Neprilysin-1; 3.4.24.11", "protein_names_refseq": "CG5905-PC; Nep1-PC; neprilysin 1, isoform C; neprilysin 1", "tax_id": 7227, "disease": "X-linked hypophosphatemic rickets (Disease Ontology:DOID:0050445); Charcot-Marie-Tooth disease axonal type 2T (Disease Ontology:DOID:0110160); cerebellar ataxia type 43 (Disease Ontology:DOID:0111745); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); membranous glomerulonephritis (Disease Ontology:DOID:10976); diarrhea (Disease Ontology:DOID:13250); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); periodontitis (Disease Ontology:DOID:824); cerebral amyloid angiopathy (Disease Ontology:DOID:9246)", "pathway": " (dme:Dmel_CG5905)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;24395329;27629706", "class_list": "", "function": "Metalloendoprotease which functions in fertility and memory formation (PubMed:24395329, PubMed:27629706). Required in the dorsal paired medial neurons and alpha/beta mushroom body neurons for the proper formation of long-term and middle-term memories (PubMed:27629706). Required in males to maximise egg-laying in female mates and is also required in females for their fertility (PubMed:24395329)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9W436-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W495-1", "uniprot_id": [ { "id": "PGAP1_DROME", "url": "https://www.uniprot.org/uniprot/Q9W495", "type": "external" } ], "mass": 111625.0, "length": 980, "protein_name": "GPI inositol-deacylase", "gene_name": "PGAP1", "organism": "Fruit fly", "refseq_name": "Post-GPI attachment to proteins 1", "refseq_ac": [ { "id": "NP_572245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572245", "type": "external" } ], "gene_names_uniprotkb": "PGAP1; CG3160", "gene_names_refseq": "CG3160; Dmel\\CG3160; PGAP1", "protein_names_uniprotkb": "GPI inositol-deacylase; 3.1.-.-; Post-GPI attachment to proteins factor 1", "protein_names_refseq": "CG3160-PA; PGAP1-PA; Post-GPI attachment to proteins 1", "tax_id": 7227, "disease": "holoprosencephaly (Disease Ontology:DOID:4621)", "pathway": " (dme:Dmel_CG3160)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Involved in inositol deacylation of GPI-anchored proteins., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8T8Q8", "ec_number_list": [], "go_molecular_function": "GO:0016788 hydrolase activity, acting on ester bonds;GO:0160215 deacylase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015031 protein transport;GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport;GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9W495-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W4J5-1", "uniprot_id": [ { "id": "NEP1_DROME", "url": "https://www.uniprot.org/uniprot/Q9W4J5", "type": "external" } ], "mass": 28359.0, "length": 252, "protein_name": "Ribosomal RNA small subunit methyltransferase NEP1", "gene_name": "CG3527", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_572170", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572170", "type": "external" } ], "gene_names_uniprotkb": "CG3527", "gene_names_refseq": "CG3527; Dmel\\CG3527; dNEP1", "protein_names_uniprotkb": "Ribosomal RNA small subunit methyltransferase NEP1; 18S rRNA (pseudouridine-N1)-methyltransferase; 2.1.1.-; Ribosome biogenesis protein NEP1", "protein_names_refseq": "CG3527-PA; uncharacterized protein", "tax_id": 7227, "disease": "Bowen-Conradi syndrome (Disease Ontology:DOID:0050684)", "pathway": " (dme:Dmel_CG3527); (R-DME-6791226)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates a pseudouridine in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Also has an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes., [UniProtKB, UniProtKB, UniProtKB]; S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position (By similarity). Also has an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0019843 rRNA binding;GO:0070037 rRNA (pseudouridine) methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0032040 small-subunit processome", "go_biological_process": "GO:0031167 rRNA methylation;GO:0042742 defense response to bacterium;GO:0042274 ribosomal small subunit biogenesis;GO:0070475 rRNA base methylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9W4J5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W4L1-1", "uniprot_id": [ { "id": "RM33_DROME", "url": "https://www.uniprot.org/uniprot/Q9W4L1", "type": "external" } ], "mass": 7697.0, "length": 64, "protein_name": "Large ribosomal subunit protein bL33m", "gene_name": "mRpL33", "organism": "Fruit fly", "refseq_name": "mitochondrial ribosomal protein L33", "refseq_ac": [ { "id": "NP_524981", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524981", "type": "external" } ], "gene_names_uniprotkb": "mRpL33; CG3712", "gene_names_refseq": "BcDNA:GH15938; CG3712; Dmel\\CG3712; L33; mRpL33", "protein_names_uniprotkb": "Large ribosomal subunit protein bL33m; 39S ribosomal protein L33, mitochondrial; L33mt; MRP-L33", "protein_names_refseq": "CG3712-PA; mRpL33-PA; mitochondrial ribosomal protein L33", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3712); (R-DME-5389840); (R-DME-5419276); (R-DME-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9W4L1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W4Q9-1", "uniprot_id": [ { "id": "INSL7_DROME", "url": "https://www.uniprot.org/uniprot/Q9W4Q9", "type": "external" } ], "mass": 18821.0, "length": 159, "protein_name": "Insulin-like peptide 7", "gene_name": "Ilp7", "organism": "Fruit fly", "refseq_name": "Insulin-like peptide 7", "refseq_ac": [ { "id": "NP_570070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570070", "type": "external" } ], "gene_names_uniprotkb": "Ilp7; CG13317", "gene_names_refseq": "CG13317; DILP 7; DILP-7; DILP7; DILPs; DILP; Dilp 7; Dilp7; Dilp; Dmel\\CG13317; ILP7; ILPs; Ilp-7; Ilp7; Ilp; dILP-7; dILP7; dIlp7; dilp-7; dilp7; dilp; dlp; ilp7", "protein_names_uniprotkb": "Insulin-like peptide 7; Insulin-related peptide 7; dILP7", "protein_names_refseq": "CG13317-PA; Ilp7-PA; Insulin-like peptide 7; drosophila insulin-like peptide 7; relaxin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13317); (R-DME-110478)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10455177;10731132;10801879;11250149;11752451;11872800;12537572;12893776;7628438;8978685;9169420;9368760", "class_list": "", "function": "Possible ligand of InR/insulin-like receptor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0008286 insulin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9W4Q9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W501-1", "uniprot_id": [ { "id": "Q9W501_DROME", "url": "https://www.uniprot.org/uniprot/Q9W501", "type": "external" } ], "mass": 45838.0, "length": 398, "protein_name": "Tempura, isoform A; Tempura, isoform B", "gene_name": "temp", "organism": "Fruit fly", "refseq_name": "tempura, isoform B", "refseq_ac": [ { "id": "NP_001284818", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284818", "type": "external" } ], "gene_names_uniprotkb": "temp; CG3073; Dmel\\CG3073; Dmel_CG3073; l(1)G0144", "gene_names_refseq": "CG3073; Dmel\\CG3073; l(1)G0144; temp", "protein_names_uniprotkb": "Tempura, isoform A; Tempura, isoform B", "protein_names_refseq": "CG3073-PB; lethal (1) G0144; temp-PB; tempura, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3073)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008318 protein prenyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005968 Rab-protein geranylgeranyltransferase complex", "go_biological_process": "GO:0007423 sensory organ development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W501-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W589-1", "uniprot_id": [ { "id": "OFUT2_DROME", "url": "https://www.uniprot.org/uniprot/Q9W589", "type": "external" } ], "mass": 56021.0, "length": 490, "protein_name": "GDP-fucose protein O-fucosyltransferase 2", "gene_name": "Ofut2", "organism": "Fruit fly", "refseq_name": "O-fucosyltransferase 2", "refseq_ac": [ { "id": "NP_569916", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569916", "type": "external" } ], "gene_names_uniprotkb": "Ofut2; CG14789; O-fut2", "gene_names_refseq": "CG14789; Dmel\\CG14789; EG:BACN32G11.6; O-FUT2; O-fut2; O-fut; OFut2; Ofut2", "protein_names_uniprotkb": "GDP-fucose protein O-fucosyltransferase 2; 2.4.1.221; O-FucT-2; Peptide-O-fucosyltransferase 2", "protein_names_refseq": "CG14789-PA; O-fucosyltransferase 2; O-fut2-PA", "tax_id": 7227, "disease": "Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (dme:Dmel_CG14789); (R-DME-5173214)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;10731137;12537569;12537572;16464857", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively. O-fucosylates members of several protein families including the ADAMTS, the thrombospondin (TSP) and spondin families., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q7K729;Q9U985", "ec_number_list": [ { "id": "2.4.1.221", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.221", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" } ], "go_molecular_function": "GO:0046922 peptide-O-fucosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0036066 protein O-linked glycosylation via fucose;GO:0006004 fucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9W589-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W5B9-1", "uniprot_id": [ { "id": "T2AH_DROME", "url": "https://www.uniprot.org/uniprot/Q9W5B9", "type": "external" } ], "mass": 12273.0, "length": 107, "protein_name": "Transcription initiation factor IIA subunit 2-2", "gene_name": "TfIIA-S-2", "organism": "Fruit fly", "refseq_name": "TfIIA-S-2", "refseq_ac": [ { "id": "NP_569877", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569877", "type": "external" } ], "gene_names_uniprotkb": "TfIIA-S-2; CG11639", "gene_names_refseq": "CG11639; Dmel\\CG11639; EG:BACR7A4.7; TFIIA-S-2; TFIIA; TfIIA-S-2; tfiia-s-2", "protein_names_uniprotkb": "Transcription initiation factor IIA subunit 2-2; General transcription factor IIA subunit 2-2; TFIIA-gamma-2; Transcription initiation factor IIA gamma-2 chain", "protein_names_refseq": "CG11639-PA; TfIIA-S-2-PA; TfIIA-S-2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11639)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DMX0;D3DMX1", "ec_number_list": [], "go_molecular_function": "GO:0017025 TBP-class protein binding;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0005672 transcription factor TFIIA complex", "go_biological_process": "GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9W5B9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W5E4-1", "uniprot_id": [ { "id": "MBB1A_DROME", "url": "https://www.uniprot.org/uniprot/Q9W5E4", "type": "external" } ], "mass": 127867.0, "length": 1133, "protein_name": "Myb-binding protein 1A", "gene_name": "Mybbp1A", "organism": "Fruit fly", "refseq_name": "MYB binding protein 1a", "refseq_ac": [ { "id": "NP_476593", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476593", "type": "external" } ], "gene_names_uniprotkb": "Mybbp1A; CG6189; l(1)Bi", "gene_names_refseq": "CG6189; Dmel\\CG6189; EG:115C2.2; HM-419; HM-52; Mybbp1A; dMYBBP1A; l(1)1Bi; l(1)Bi; l(1)lBi; mybbp1a", "protein_names_uniprotkb": "Myb-binding protein 1A", "protein_names_refseq": "CG6189-PA; MYB binding protein 1a; Mybbp1A-PA; lethal (1) 1Bi", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6189)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;29065309", "class_list": "", "function": "Has a role in rRNA biogenesis, cell proliferation and tissue growth by contributing to the localization of nclb to the nucleolus., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BIF7;Q8MRJ3", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0042254 ribosome biogenesis;GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I;GO:0090070 positive regulation of ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9W5E4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W5G6-1", "uniprot_id": [ { "id": "OR1A_DROME", "url": "https://www.uniprot.org/uniprot/Q9W5G6", "type": "external" } ], "mass": 44960.0, "length": 392, "protein_name": "Odorant receptor 1a", "gene_name": "Or1a", "organism": "Fruit fly", "refseq_name": "odorant receptor 1a", "refseq_ac": [ { "id": "NP_525029", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_525029", "type": "external" } ], "gene_names_uniprotkb": "Or1a; CG17885", "gene_names_refseq": "1A.1; 1a; CG17885; DOR68; Dmel\\CG17885; OR1a; Or1a", "protein_names_uniprotkb": "Odorant receptor 1a", "protein_names_refseq": "CG17885-PA; Or1a-PA; odorant receptor 1a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17885)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;10943836;12537572;19502424;21857978", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to butanal, heptanal, and 2-heptanone., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0042048 olfactory behavior;GO:0007165 signal transduction;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9W5G6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W5R8-1", "uniprot_id": [ { "id": "RL5_DROME", "url": "https://www.uniprot.org/uniprot/Q9W5R8", "type": "external" } ], "mass": 34037.0, "length": 299, "protein_name": "Large ribosomal subunit protein uL18", "gene_name": "RpL5", "organism": "Fruit fly", "refseq_name": "ribosomal protein L5, isoform A", "refseq_ac": [ { "id": "NP_001036387", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036387", "type": "external" } ], "gene_names_uniprotkb": "RpL5; CG17489; Dmel\\CG17489; Dmel_CG17489; E-2d; L18; L5; M(2)40B; RPL5; Rp L5; Rpl5; dRPL5; yip6", "gene_names_refseq": "CG17489; Dmel\\CG17489; E-2d; L18; L5; M(2)40B; RPL5; Rp L5; RpL5; Rpl5; dRPL5; yip6", "protein_names_uniprotkb": "Large ribosomal subunit protein uL18; 60S ribosomal protein L5", "protein_names_refseq": "CG17489-PA; RpL5-PA; enhancer on chromosome 2, complementation group d; ribosomal protein L5, isoform A; ribosomal protein L5; yippee interacting protein 6", "tax_id": 7227, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); Diamond-Blackfan anemia 6 (Disease Ontology:DOID:0111879); Diamond-Blackfan anemia (Disease Ontology:DOID:1339); glioblastoma (Disease Ontology:DOID:3068); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603)", "pathway": " (dme:Dmel_CG17489); (R-DME-156827); (R-DME-1799339); (R-DME-72689); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954709); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 10, "publication_count": 14, "publication_id_list": "10731132;12368261;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;23636399;25589440;26109356;26109357", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008097 5S rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0022626 cytosolic ribosome;GO:0022625 cytosolic large ribosomal subunit;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0000027 ribosomal large subunit assembly;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9W5R8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W5Y0-1", "uniprot_id": [ { "id": "NEP3_DROME", "url": "https://www.uniprot.org/uniprot/Q9W5Y0", "type": "external" } ], "mass": 89759.0, "length": 786, "protein_name": "Neprilysin-3", "gene_name": "Nep3", "organism": "Fruit fly", "refseq_name": "neprilysin 3, isoform B", "refseq_ac": [ { "id": "NP_001245775", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245775", "type": "external" } ], "gene_names_uniprotkb": "Nep3; CG9565", "gene_names_refseq": "CEC; CG9565; DmeNEP3; Dmel\\CG9565; NEP3; Nep3; dNEP3; nep3", "protein_names_uniprotkb": "Neprilysin-3; 3.4.24.11", "protein_names_refseq": "CG9565-PB; Nep3-PB; neprilysin 3, isoform B; neprilysin 3", "tax_id": 7227, "disease": "renal fibrosis (Disease Ontology:DOID:0050855); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); nephrotic syndrome (Disease Ontology:DOID:1184); dilated cardiomyopathy (Disease Ontology:DOID:12930); acute kidney failure (Disease Ontology:DOID:3021); coronary artery disease (Disease Ontology:DOID:3393); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); double outlet right ventricle (Disease Ontology:DOID:6406); pulmonary hypertension (Disease Ontology:DOID:6432); hyperhomocysteinemia (Disease Ontology:DOID:9279)", "pathway": " (dme:Dmel_CG9565); (R-DME-2022377); (R-DME-5578768); (R-DME-6798695)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;24395329;27629706", "class_list": "", "function": "Metalloendoprotease which is required in the dorsal paired medial neurons for the proper formation of long-term (LTM) and middle-term memories (MTM). Also required in the mushroom body neurons where it functions redundantly with neprilysins Nep2 and Nep4 in normal LTM formation., [UniProtKB, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 11, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q8SWS1", "ec_number_list": [ { "id": "1.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.-", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0016486 peptide hormone processing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9W5Y0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9XZ34-1", "uniprot_id": [ { "id": "RIF1_DROME", "url": "https://www.uniprot.org/uniprot/Q9XZ34", "type": "external" } ], "mass": 156820.0, "length": 1416, "protein_name": "Telomere-associated protein RIF1", "gene_name": "Rif1", "organism": "Fruit fly", "refseq_name": "Rap1 interacting factor 1", "refseq_ac": [ { "id": "NP_725497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_725497", "type": "external" } ], "gene_names_uniprotkb": "Rif1; CG30085", "gene_names_refseq": "BcDNA:LD22218; CG30085; Dmel\\CG30085; Rif1; XM_080537.1; dRif1", "protein_names_uniprotkb": "Telomere-associated protein RIF1; Rap1 interacting factor 1", "protein_names_refseq": "CG30085-PA; Rap1 interacting factor 1 homolog; Rap1 interacting factor 1; Rif1-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG30085)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10731132;10731138;12537572;22712556;26022086;26859551;29746464;30277458", "class_list": "", "function": "Regulates the timing of initiation of DNA replication (PubMed:26022086, PubMed:29746464, PubMed:30277458). Functions in copy number control by promoting the underreplication of DNA, which is found in many late replicating euchromatic regions of salivary gland polytene chromosomes (PubMed:30277458). Promotes underreplication by localizing to active DNA replication forks in a partially SuUR-dependent manner, and inhibiting replication fork progression (PubMed:30277458). Might also work as an adapter to recruit Pp1-87B to multiple sites on the chromosome and may function with Pp1-87B to mediate underreplication (PubMed:26022086, PubMed:29746464, PubMed:30277458). Plays an essential role in embryonic development, in the transition from larvae to pupae and, probably, in proliferating tissues later on (PubMed:26022086, PubMed:29746464). In embryos, during mid-blastula transition, binds to and selectively delays the replication of large blocks of repetitive DNA satellite sequences during S phase in response to the activity of Cdk1; maternal Rif1 is specifically required for the normal extension of S phase 14 (PubMed:29746464). Unlike mammalian orthologs, does not appear to play a role in DNA damage repair (PubMed:22712556, PubMed:26022086)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 17, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4V5E2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0000792 heterochromatin;GO:0010369 chromocenter;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0030174 regulation of DNA-templated DNA replication initiation;GO:2000104 negative regulation of DNA-templated DNA replication;GO:0000723 telomere maintenance;GO:1901991 negative regulation of mitotic cell cycle phase transition;GO:0071807 replication fork arrest involved in DNA replication termination", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9XZ34-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9XZU1-1", "uniprot_id": [ { "id": "XPO2_DROME", "url": "https://www.uniprot.org/uniprot/Q9XZU1", "type": "external" } ], "mass": 110168.0, "length": 975, "protein_name": "Exportin-2", "gene_name": "Cse1", "organism": "Fruit fly", "refseq_name": "chromosome segregation 1", "refseq_ac": [ { "id": "NP_523588", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523588", "type": "external" } ], "gene_names_uniprotkb": "Cse1; CG13281; Cas", "gene_names_refseq": "BcDNA:LD14270; CAS; CG13281; Cas; Cse1; Dcas; Dmel\\CG13281; cas; cse; dcas; l(2)k03902", "protein_names_uniprotkb": "Exportin-2; Cellular apoptosis susceptibility protein homolog; Chromosome segregation protein 1; Exp2; Importin-alpha re-exporter", "protein_names_refseq": "CAS/CSE1 segregation protein; CG13281-PA; Cse1-PA; Importin-alpha re-exporter; chromosome segregation 1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13281)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;10731138;11944946;12537572", "class_list": "", "function": "Export receptor for importin alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9UB14;Q9VJH4", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0005049 nuclear export signal receptor activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006611 protein export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9XZU1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Y0V3-1", "uniprot_id": [ { "id": "T10B_DROME", "url": "https://www.uniprot.org/uniprot/Q9Y0V3", "type": "external" } ], "mass": 13520.0, "length": 117, "protein_name": "Mitochondrial import inner membrane translocase subunit Tim10B", "gene_name": "Tim9b", "organism": "Fruit fly", "refseq_name": "translocase of inner membrane 9b, isoform C", "refseq_ac": [ { "id": "NP_001027074", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027074", "type": "external" } ], "gene_names_uniprotkb": "Tim9b; CG17767; tim9", "gene_names_refseq": "CG17767; CG33066; Dmel\\CG17767; Dromel_CG12788_CG17767_FBtr0074_tim9b_uORF; Tim12; Tim9b; Tim9; Timm9; tim9", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit Tim10B; Mitochondrial import inner membrane translocase subunit Tim9B; Tim10b", "protein_names_refseq": "CG17767-PC; Tim9b-PC; translocase of inner membrane 9b, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17767); (R-DME-1268020)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10611480;10731132;12537572", "class_list": "", "function": "Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V4S9", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0140318 protein transporter activity", "go_cellular_component": "GO:0042719 mitochondrial intermembrane space chaperone complex;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0042721 TIM22 mitochondrial import inner membrane insertion complex", "go_biological_process": "GO:0015031 protein transport;GO:0045039 protein insertion into mitochondrial inner membrane;GO:0071456 cellular response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9Y0V3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Y0Y2-1", "uniprot_id": [ { "id": "PURA_DROME", "url": "https://www.uniprot.org/uniprot/Q9Y0Y2", "type": "external" } ], "mass": 48901.0, "length": 447, "protein_name": "Adenylosuccinate synthetase", "gene_name": "Adss", "organism": "Fruit fly", "refseq_name": "adenylosuccinate synthetase", "refseq_ac": [ { "id": "NP_650918", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650918", "type": "external" } ], "gene_names_uniprotkb": "Adss; CG17273", "gene_names_refseq": "AdSS; Adss; BcDNA:LD32788; CG17273; Dmel\\CG17273; PURA_DROME", "protein_names_uniprotkb": "Adenylosuccinate synthetase; 6.3.4.4; AMPSase; AdSS; IMP--aspartate ligase", "protein_names_refseq": "Adss-PA; CG17273-PA; adenylosuccinate synthetase", "tax_id": 7227, "disease": "sarcoma (Disease Ontology:DOID:1115)", "pathway": " (dme:Dmel_CG17273); (R-DME-73817)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;10731138;12537569;12537572;23312286", "class_list": "", "function": "Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Plays a role in the regulation of adult life span., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MZ11;Q9VDI2", "ec_number_list": [ { "id": "6.3.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.4", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005525 GTP binding;GO:0004019 adenylosuccinate synthase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0046040 IMP metabolic process;GO:0044208 'de novo' AMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9Y0Y2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Y103-1", "uniprot_id": [ { "id": "TFP11_DROME", "url": "https://www.uniprot.org/uniprot/Q9Y103", "type": "external" } ], "mass": 94828.0, "length": 839, "protein_name": "Septin-interacting protein 1", "gene_name": "sip1", "organism": "Fruit fly", "refseq_name": "septin interacting protein 1, isoform B", "refseq_ac": [ { "id": "NP_001285636", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285636", "type": "external" } ], "gene_names_uniprotkb": "sip1; BcDNA:GH11690; CG7238; Dmel\\CG7238; Dmel_CG7238; GH11690; Sip1; stip-1", "gene_names_refseq": "BcDNA:GH11690; CG7238; Dmel\\CG7238; GH11690; Sip1; sip1", "protein_names_uniprotkb": "Septin-interacting protein 1; STIP-1; Septin and tuftelin-interacting protein 1", "protein_names_refseq": "CG7238-PB; septin interacting protein 1, isoform B; sip1-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7238)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;11884525;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "May be involved in pre-mRNA splicing., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9NHN7", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome;GO:0071011 precatalytic spliceosome;GO:0071008 U2-type post-mRNA release spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0000390 spliceosomal complex disassembly", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9Y103-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Y113-1", "uniprot_id": [ { "id": "NELFB_DROME", "url": "https://www.uniprot.org/uniprot/Q9Y113", "type": "external" } ], "mass": 67935.0, "length": 594, "protein_name": "Negative elongation factor B", "gene_name": "NELF-B", "organism": "Fruit fly", "refseq_name": "NELF-B", "refseq_ac": [ { "id": "NP_572402", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572402", "type": "external" } ], "gene_names_uniprotkb": "NELF-B; CG32721", "gene_names_refseq": "BcDNA:GH10333; CG12152; CG32721; Dmel\\CG32721; NELF-B; NELF; NelfB", "protein_names_uniprotkb": "Negative elongation factor B", "protein_names_refseq": "CG32721-PA; NELF-B-PA; NELF-B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32721); (R-DME-112382); (R-DME-113418); (R-DME-674695); (R-DME-6796648); (R-DME-75955)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "10731132;10731138;12537572;15741180;29281702", "class_list": "", "function": "Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0017053 transcription repressor complex;GO:0005694 chromosome;GO:0032021 NELF complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034244 negative regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9Y113-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Y169-1", "uniprot_id": [ { "id": "EXT2_DROME", "url": "https://www.uniprot.org/uniprot/Q9Y169", "type": "external" } ], "mass": 82726.0, "length": 717, "protein_name": "Exostosin-2", "gene_name": "sotv", "organism": "Fruit fly", "refseq_name": "sister of tout-velu", "refseq_ac": [ { "id": "NP_725536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_725536", "type": "external" } ], "gene_names_uniprotkb": "sotv; CG33038; Ext2", "gene_names_refseq": "BcDNA:GH02288; CG33038; CG8433; DEXT2; DExt2; Dmel\\CG8433; EXT2; Ext2; Sotv; dExt2; sotv", "protein_names_uniprotkb": "Exostosin-2; 2.4.1.224; 2.4.1.225; Protein sister of tout-velu", "protein_names_refseq": "CG8433-PB; Ext2; sister of tout-velu; sister of ttv; sister-of-tout-velu; sotv-PB", "tax_id": 7227, "disease": "hereditary multiple exostoses (Disease Ontology:DOID:206)", "pathway": " (dme:Dmel_CG8433); (R-DME-2022928)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10731132;10731138;12537572;14645127;14998928;15056609;23720043", "class_list": "glycogene;glycosyltransferase", "function": "Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. Plays a central role in diffusion of morphogens hedgehog (hh), wingless (wg) and Decapentaplegic (dpp) via its role in heparan sulfate proteoglycans (HSPGs) biosynthesis, HSPGs being required for movement of Hh, Dpp and wg morphogens., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A4UZJ2", "ec_number_list": [ { "id": "2.4.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.17", "type": "external" }, { "id": "2.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.-.-", "type": "external" }, { "id": "2.4.1.224", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.224", "type": "external" }, { "id": "2.4.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.225", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008375 acetylglucosaminyltransferase activity;GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity;GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0120504 EXT1-EXT2 complex", "go_biological_process": "GO:0016055 Wnt signaling pathway;GO:0030210 heparin proteoglycan biosynthetic process;GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Y169-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Y1B2-1", "uniprot_id": [ { "id": "ORC6_DROME", "url": "https://www.uniprot.org/uniprot/Q9Y1B2", "type": "external" } ], "mass": 29239.0, "length": 257, "protein_name": "Origin recognition complex subunit 6", "gene_name": "Orc6", "organism": "Fruit fly", "refseq_name": "origin recognition complex subunit 6", "refseq_ac": [ { "id": "NP_477319", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477319", "type": "external" } ], "gene_names_uniprotkb": "Orc6; CG1584", "gene_names_refseq": "CG1584; DmORC 6; DmORC6; Dmel\\CG1584; ORC6; ORC; Orc6; orc6; rDmORC", "protein_names_uniprotkb": "Origin recognition complex subunit 6", "protein_names_refseq": "CG1584-PA; Orc6-PA; origin recognition complex subunit 6", "tax_id": 7227, "disease": "Meier-Gorlin syndrome 3 (Disease Ontology:DOID:0080514)", "pathway": " (dme:Dmel_CG1584); (R-DME-176187); (R-DME-68616); (R-DME-68689); (R-DME-68949); (R-DME-68962)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "10346817;10731132;12537569;12537572", "class_list": "", "function": "Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9V5C5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005096 GTPase activator activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0032156 septin cytoskeleton;GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0005664 nuclear origin of replication recognition complex;GO:0000808 origin recognition complex", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006260 DNA replication;GO:0006270 DNA replication initiation;GO:0032185 septin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9Y1B2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "X2JAU8-1", "uniprot_id": [ { "id": "NWK_DROME", "url": "https://www.uniprot.org/uniprot/X2JAU8", "type": "external" } ], "mass": 117255.0, "length": 1075, "protein_name": "Protein nervous wreck", "gene_name": "nwk", "organism": "Fruit fly", "refseq_name": "nervous wreck, isoform B", "refseq_ac": [ { "id": "NP_001246689", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246689", "type": "external" } ], "gene_names_uniprotkb": "nwk; CG43479", "gene_names_refseq": "CG43479; CG4641; CG4684; Dmel\\CG43479; NWK; Nwk; nwk", "protein_names_uniprotkb": "Protein nervous wreck; Nwk", "protein_names_refseq": "CG43479-PB; nervous wreck, isoform B; nervous wreck; nwk-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG43479)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537572;14980202;18498733;18701694;21464232;23761074;26567222;26686642;27601635;29568072", "class_list": "", "function": "Adapter protein that provides a link between vesicular membrane traffic and the actin assembly machinery. Acts together with Cdc42 to stimulate actin nucleation mediated by WASp and the ARP2/3 complex (PubMed:18701694, PubMed:27601635). Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and causes local membrane deformation (PubMed:23761074, PubMed:26686642). Required for normal structure and function of synapses at the neuromuscular junction (PubMed:14980202, PubMed:18498733, PubMed:18701694, PubMed:21464232, PubMed:26567222, PubMed:26686642, PubMed:27601635, PubMed:29568072). Plays a role in synaptic vesicle trafficking (PubMed:29568072). Required for the release of a normal number of synaptic vesicles per action potential (PubMed:26567222)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "M9NE66;M9NF56;M9NFQ1;Q9VSU8;X2J8V0;X2JC77;X2JCQ1;X2JGF9", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030424 axon;GO:0031594 neuromuscular junction;GO:0055037 recycling endosome;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0007274 neuromuscular synaptic transmission;GO:0061024 membrane organization;GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation;GO:0001881 receptor recycling;GO:0030833 regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "X2JAU8-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A021WW64-1", "uniprot_id": [ { "id": "A0A021WW64_DROME", "url": "https://www.uniprot.org/uniprot/A0A021WW64", "type": "external" } ], "mass": 30480.0, "length": 274, "protein_name": "Uncharacterized protein", "gene_name": "FBgn0058460", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform G", "refseq_ac": [ { "id": "NP_001287647", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287647", "type": "external" } ], "gene_names_uniprotkb": "FBgn0058460; CG17162; CG40460; Dmel\\CG17162; Dmel_CG17162; anon-20Ea", "gene_names_refseq": "CG17162; CG40460; Dmel\\CG17162; FBgn0058460; anon-20Ea", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG17162-PG; uncharacterized protein, isoform G", "tax_id": 7227, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A0A021WW64-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4JCZ8-1", "uniprot_id": [ { "id": "A0A0B4JCZ8_DROME", "url": "https://www.uniprot.org/uniprot/A0A0B4JCZ8", "type": "external" } ], "mass": 218458.0, "length": 2028, "protein_name": "Missing-in-metastasis, isoform F", "gene_name": "mim", "organism": "Fruit fly", "refseq_name": "missing-in-metastasis, isoform F", "refseq_ac": [ { "id": "NP_001188869", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001188869", "type": "external" } ], "gene_names_uniprotkb": "mim; CG33352; CG33558; CG9469; Dm_2R:10851; Dmel\\CG33558; Dmel_CG33558; MIM; Mim; anon-EST:fe1E4; dmim", "gene_names_refseq": "CG33352; CG33558; CG9469; Dm_2R:10851; Dmel\\CG33558; MIM; Mim; anon-EST:fe1E4; dmim; mim", "protein_names_uniprotkb": "Missing-in-metastasis, isoform F", "protein_names_refseq": "CG33558-PF; anon-fast-evolving-1E4; mim-PF; missing-in-metastasis, isoform F", "tax_id": 7227, "disease": "non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); intellectual developmental disorder with ocular anomalies and distinctive facial features (Disease Ontology:DOID:0081301)", "pathway": " (dme:Dmel_CG33558)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005543 phospholipid binding;GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0032991 protein-containing complex;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0007009 plasma membrane organization;GO:0046847 filopodium assembly;GO:0048261 negative regulation of receptor-mediated endocytosis;GO:0008354 germ cell migration;GO:0007298 border follicle cell migration", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A0A0B4JCZ8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4LH08-1", "uniprot_id": [ { "id": "A0A0B4LH08_DROME", "url": "https://www.uniprot.org/uniprot/A0A0B4LH08", "type": "external" } ], "mass": 361322.0, "length": 3213, "protein_name": "TBC1 domain family member 30", "gene_name": "blobby", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform G", "refseq_ac": [ { "id": "NP_001287272", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287272", "type": "external" } ], "gene_names_uniprotkb": "blobby; CG12816; CG34108; CG3996; CG42795; Dmel\\CG42795; Dmel_CG42795", "gene_names_refseq": "CG12816; CG34108; CG3996; CG42795; Dmel\\CG42795", "protein_names_uniprotkb": "TBC1 domain family member 30", "protein_names_refseq": "CG42795-PG; uncharacterized protein, isoform G", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG42795)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0098882 structural constituent of presynaptic active zone", "go_cellular_component": "GO:0048786 presynaptic active zone", "go_biological_process": "GO:1904071 presynaptic active zone assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A0A0B4LH08-1", "record_type": "protein", "filter_code": "0000000.0000101.001000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4JCY9-1", "uniprot_id": [ { "id": "A0A0B4JCY9_DROME", "url": "https://www.uniprot.org/uniprot/A0A0B4JCY9", "type": "external" } ], "mass": 7212.0, "length": 66, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG42869", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_001189264", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001189264", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG42869; 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CG43335; CG5302; Dmel\\CG43335; Dmel_CG43335; SP73a", "gene_names_refseq": "CG43335; CG5302; Dmel\\CG43335; SP73a; SPH73", "protein_names_uniprotkb": "Peptidase S1 domain-containing protein", "protein_names_refseq": "CG43335-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG43335)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0045087 innate immune response;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A0A0B4K687-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4KHL4-1", "uniprot_id": [ { "id": "A0A0B4KHL4_DROME", "url": "https://www.uniprot.org/uniprot/A0A0B4KHL4", "type": "external" } ], "mass": 60127.0, "length": 537, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "gish", "organism": "Fruit fly", "refseq_name": "gilgamesh, isoform L", "refseq_ac": [ { "id": "NP_001262624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262624", "type": "external" } ], "gene_names_uniprotkb": "gish; CG6963; CK1-gamma; CK1[[gamma]]; CK1gamma; CK1; CKI-related; CKIgamma; Dmel\\CG6963; Dmel_CG6963; Gish; Hrr25; NEST:bs27c08; Spider; anon-WO0118547.425; ms(3)89B; spider", "gene_names_refseq": "CG6963; CK1-gamma; CK1[[gamma]]; CK1gamma; CK1; CKI-related; CKIgamma; Dmel\\CG6963; Gish; Hrr25; NEST:bs27c08; Spider; anon-WO0118547.425; gish; ms(3)89B; spider", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "CG6963-PL; CKIg-like; NEST:bs27c08; casein kinase 1gamma; gilgamesh, isoform L; gilgamesh; gish-PL; spider", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6963); (R-DME-1660661); (R-DME-209387); (R-DME-209440); (R-DME-209472)", "pathway_count": 5, "publication_count": 26, "publication_id_list": "10196136;10421629;10731132;10846164;10949033;11336703;12205098;12537568;12537572;12537573;12537574;12636921;12781135;14636582;14731402;15459103;16110336;16163385;16341016;16987508;17569856;17569867;25589440;26109356;26109357;8717036", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "5.6.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.8", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0070864 sperm individualization complex;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0032880 regulation of protein localization;GO:0016055 Wnt signaling pathway;GO:0008355 olfactory learning;GO:0051126 negative regulation of actin nucleation;GO:0007291 sperm individualization", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "A0A0B4KHL4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4K6E6-1", "uniprot_id": [ { "id": "A0A0B4K6E6_DROME", "url": "https://www.uniprot.org/uniprot/A0A0B4K6E6", "type": "external" } ], "mass": 11849.0, "length": 106, "protein_name": "Uncharacterized protein", "gene_name": "BcDNA:RH54117; Dmel\\CG17734", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform C", "refseq_ac": [ { "id": "NP_001247043", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001247043", "type": "external" } ], "gene_names_uniprotkb": "BcDNA:RH54117; Dmel\\CG17734; BcDNA:RH54117; CG17734; Dmel\\CG17734; Dmel_CG17734", "gene_names_refseq": "BcDNA:RH54117; CG17734; Dmel\\CG17734", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG17734-PC; uncharacterized protein, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17734); (R-DME-5628897); (R-DME-611105); (R-DME-9707564)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0048149 behavioral response to ethanol;GO:0097250 mitochondrial respirasome assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A0A0B4K6E6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4K6F9-1", "uniprot_id": [ { "id": "A0A0B4K6F9_DROME", "url": "https://www.uniprot.org/uniprot/A0A0B4K6F9", "type": "external" } ], "mass": 94852.0, "length": 853, "protein_name": "Extended synaptotagmin-like protein 2, isoform C", "gene_name": "Esyt2", "organism": "Fruit fly", "refseq_name": "extended synaptotagmin-like protein 2, isoform C", "refseq_ac": [ { "id": "NP_001247287", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001247287", "type": "external" } ], "gene_names_uniprotkb": "Esyt2; CG6643; Dmel\\CG6643; Dmel_CG6643; E-Syt2; Esyt; Tricalbin; dESyt; dEsyt", "gene_names_refseq": "CG6643; Dmel\\CG6643; E-Syt2; Esyt2; Esyt; Tricalbin; dESyt; dEsyt", "protein_names_uniprotkb": "Extended synaptotagmin-like protein 2, isoform C", "protein_names_refseq": "CG6643-PC; Esyt2-PC; extended synaptotagmin-like protein 2 ortholog; extended synaptotagmin-like protein 2, isoform C; tricalbin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6643); (R-DME-9035034); (R-DME-9845576)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0008429 phosphatidylethanolamine binding;GO:0031210 phosphatidylcholine binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0098793 presynapse;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0061670 evoked neurotransmitter secretion;GO:0006869 lipid transport;GO:0061817 endoplasmic reticulum-plasma membrane tethering", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A0A0B4K6F9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4K6G5-1", "uniprot_id": [ { "id": "A0A0B4K6G5_DROME", "url": "https://www.uniprot.org/uniprot/A0A0B4K6G5", "type": "external" } ], "mass": 77094.0, "length": 714, "protein_name": "Na[+]/H[+] hydrogen antiporter 2, isoform B", "gene_name": "Nha2", "organism": "Fruit fly", "refseq_name": "Na[+]/H[+] hydrogen antiporter 2, isoform B", "refseq_ac": [ { "id": "NP_001247251", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001247251", "type": "external" } ], "gene_names_uniprotkb": "Nha2; CG31052; CG43205; CG43442; CG4682; CG4693; DMG8-chr3R.34.001; DmNHA2; Dmel\\CG43442; Dmel_CG43442; TANGO12; Tango12; nha2; tango12", "gene_names_refseq": "CG31052; CG43205; CG43442; CG4682; CG4693; DMG8-chr3R.34.001; DmNHA2; Dmel\\CG43442; Nha2; TANGO12; Tango12; nha2; tango12", "protein_names_uniprotkb": "Na[+]/H[+] hydrogen antiporter 2, isoform B", "protein_names_refseq": "CG43442-PB; Na[+]/H[+] hydrogen antiporter 2, isoform B; Nha2-PB; transport and golgi organization 12", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG43442); (R-DME-2672351)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015385 sodium:proton antiporter activity;GO:0022821 solute:potassium antiporter activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005903 brush border", "go_biological_process": "GO:0003096 renal sodium ion transport;GO:0009306 protein secretion;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A0A0B4K6G5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4K7N1-1", "uniprot_id": [ { "id": "A0A0B4K7N1_DROME", "url": "https://www.uniprot.org/uniprot/A0A0B4K7N1", "type": "external" } ], "mass": 106582.0, "length": 986, "protein_name": "Sidestep, isoform C", "gene_name": "side", "organism": "Fruit fly", "refseq_name": "sidestep, isoform C", "refseq_ac": [ { "id": "NP_001247334", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001247334", "type": "external" } ], "gene_names_uniprotkb": "side; 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B; CG8183; DmKIN73; DmKin73; DmKlp73; Dmel\\CG8183; Dmel_CG8183; KHC-73; KIF 13A; KLP73; Khc 73; Khc73; Kin73; Kinesin-73; anon-EST:fe3C9; khc-73; khc73", "gene_names_refseq": "CG8183; DmKIN73; DmKin73; DmKlp73; Dmel\\CG8183; KHC-73; KIF 13A; KIF13A/B; KLP73; Khc 73; Khc-73; Khc73; Kin73; Kinesin-73; anon-EST:fe3C9; khc-73; khc73", "protein_names_uniprotkb": "Kinesin heavy chain 73, isoform E", "protein_names_refseq": "CG8183-PE; Khc-73-PE; Kinesin-3; Kinesin-73; Kinesin3B; anon-fast-evolving-3C9; kinesin heavy chain 73, isoform E; kinesin heavy-chain 73", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8183)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0042803 protein homodimerization activity;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005874 microtubule;GO:0005871 kinesin complex;GO:0035371 microtubule plus-end", "go_biological_process": "GO:0051294 establishment of spindle orientation;GO:0050803 regulation of synapse structure or activity;GO:0007018 microtubule-based movement;GO:0090328 regulation of olfactory learning", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A0A0B4KFR5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4KFT9-1", "uniprot_id": [ { "id": "A0A0B4KFT9_DROME", "url": "https://www.uniprot.org/uniprot/A0A0B4KFT9", "type": "external" } ], "mass": 66774.0, "length": 617, "protein_name": "Quaking related 54B, isoform E", "gene_name": "qkr54B", "organism": "Fruit fly", "refseq_name": "quaking related 54B, isoform E", "refseq_ac": [ { "id": "NP_001261050", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261050", "type": "external" } ], "gene_names_uniprotkb": "qkr54B; 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3041; APT; Apt; CG5393; Dmel\\CG5393; Dmel_CG5393; TDF; Tdp; l(2)03041; l(2)06369; l(2)09049; l(2)59Ea; l(2)k11531; tdf", "gene_names_refseq": "3041; APT; Apt; CG5393; Dmel\\CG5393; TDF/APT; TDF; Tdp; apt; l(2)03041; l(2)06369; l(2)09049; l(2)59Ea; l(2)k11531; tdf", "protein_names_uniprotkb": "Regulatory protein zeste", "protein_names_refseq": "CG5393-PF; apontic, isoform F; apontic; apt-PF; trachea defective; tracheae defective; tracheal defective", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5393)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. 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CG5952; Dmel\\CG5952; Dmel_CG5952; bHLHa33; fer2", "gene_names_refseq": "CG5952; Dmel\\CG5952; Fer2; bHLHa33; fer2", "protein_names_uniprotkb": "48 related 2, isoform D", "protein_names_refseq": "48 related 2, isoform D; 48-related 2; 48-related-2; CG5952-PD; Fer2-PD; ferritin 2", "tax_id": 7227, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (dme:Dmel_CG5952)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046983 protein dimerization activity;GO:0003682 chromatin binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006979 response to oxidative stress;GO:0006355 regulation of DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0032502 developmental process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A0A0B4LH78-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4LHC9-1", "uniprot_id": [ { "id": "A0A0B4LHC9_DROME", "url": "https://www.uniprot.org/uniprot/A0A0B4LHC9", "type": "external" } ], "mass": 37227.0, "length": 330, "protein_name": "Thioredoxin-related transmembrane protein 1", "gene_name": "Dmel\\CG5554", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001286784", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286784", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG5554; CG5554; Dmel_CG5554", "gene_names_refseq": "CG5554; Dmel\\CG5554", "protein_names_uniprotkb": "Thioredoxin-related transmembrane protein 1; Protein disulfide-isomerase TMX1; Thioredoxin domain-containing protein 1", "protein_names_refseq": "CG5554-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5554)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015036 disulfide oxidoreductase activity;GO:0015035 protein-disulfide reductase activity;GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A0A0B4LHC9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4LHI9-1", "uniprot_id": [ { "id": "A0A0B4LHI9_DROME", "url": "https://www.uniprot.org/uniprot/A0A0B4LHI9", "type": "external" } ], "mass": 51864.0, "length": 454, "protein_name": "Inwardly rectifying potassium channel 2, isoform D", "gene_name": "Irk2", "organism": "Fruit fly", "refseq_name": "inwardly rectifying potassium channel 2, isoform D", "refseq_ac": [ { "id": "NP_001287485", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287485", "type": "external" } ], "gene_names_uniprotkb": "Irk2; 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"type": "external" } ], "mass": 152387.0, "length": 1350, "protein_name": "Phospholipid-transporting ATPase", "gene_name": "ATP8A", "organism": "Fruit fly", "refseq_name": "ATPase 8A, isoform H", "refseq_ac": [ { "id": "NP_001137651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137651", "type": "external" } ], "gene_names_uniprotkb": "ATP8A; Atp8a; CG17034; CG30061; CG42321; DmCG42321; Dmel\\CG42321; Dmel_CG42321; anon-WO0153538.54", "gene_names_refseq": "ATP8A; Atp8a; CG17034; CG30061; CG42321; DmCG42321; Dmel\\CG42321; anon-WO0153538.54", "protein_names_uniprotkb": "Phospholipid-transporting ATPase; 7.6.2.1", "protein_names_refseq": "ATP8A-PH; ATPase 8A, isoform H; CG42321-PH", "tax_id": 7227, "disease": "cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome (Disease Ontology:DOID:0050997); cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 4 (Disease Ontology:DOID:0070559)", "pathway": " (dme:Dmel_CG42321); 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"https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.78", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0090556 phosphatidylserine floppase activity;GO:0140326 ATPase-coupled intramembrane lipid transporter activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0045332 phospholipid translocation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "B7YZF8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E2QD16-1", "uniprot_id": [ { "id": "E2QD16_DROME", "url": "https://www.uniprot.org/uniprot/E2QD16", "type": "external" } ], "mass": 169778.0, "length": 1570, "protein_name": "Non-specific lethal 1, isoform M", "gene_name": "nsl1", "organism": "Fruit fly", "refseq_name": "non-specific lethal 1, isoform M", "refseq_ac": [ { "id": "NP_732069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_732069", "type": "external" } ], "gene_names_uniprotkb": "nsl1; CG4699; Dmel\\CG4699; Dmel_CG4699; E(nos); NSL1; Nsl1; l(3)06536; l(3)S009413; wah", "gene_names_refseq": "CG4699; Dmel\\CG4699; E(nos); NSL1; Nsl1; l(3)06536; l(3)S009413; nsl1; wah", "protein_names_uniprotkb": "Non-specific lethal 1, isoform M", "protein_names_refseq": "CG4699-PM; lethal (3) 06536; non-specific lethal 1, isoform M; nonspecific lethal 1; nsl1-PM; waharan", "tax_id": 7227, "disease": "Koolen de Vries syndrome (Disease Ontology:DOID:0050880); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (dme:Dmel_CG4699); (R-DME-3214847); (R-DME-9772755)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;24788516;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, 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"0000000.0000111.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1Z9J3-1", "uniprot_id": [ { "id": "A1Z9J3_DROME", "url": "https://www.uniprot.org/uniprot/A1Z9J3", "type": "external" } ], "mass": 989549.0, "length": 8805, "protein_name": "Short stop, isoform H", "gene_name": "shot", "organism": "Fruit fly", "refseq_name": "short stop, isoform H", "refseq_ac": [ { "id": "NP_725339", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_725339", "type": "external" } ], "gene_names_uniprotkb": "shot; 4; CG18076; CG18637; Dmel\\CG18076; Dmel_CG18076; EN2-12; Grv; Kak; Shot; Su(Mir)1; grv; kakapo; kakp; kak; kop; l(2)CA4; l(2)k03010; l(2)k04204; l(2)k05434; l(2)k05821; l(2)k10821; l(2)k15606", "gene_names_refseq": "42/4; CG18076; CG18637; Dmel\\CG18076; EN2-12; Grv; Kak; Shot; Su(Mir)1; grv; kakp; kak; kop; l(2)CA4; l(2)k03010; l(2)k04204; l(2)k05434; l(2)k05821; l(2)k10821; l(2)k15606; shortstop/kakapo; shot", "protein_names_uniprotkb": "Short stop, isoform H", "protein_names_refseq": "CG18076-PH; enhancer of NA9 2-12; groovin; kakapoo; kakapo; kopupu; short stop, isoform H; short stop; short-stop; shortshop; shortstop; shot-PH; spectraplakin", "tax_id": 7227, "disease": "hereditary sensory and autonomic neuropathy (Disease Ontology:DOID:0050548); hereditary sensory and autonomic neuropathy type 6 (Disease Ontology:DOID:0070151); lissencephaly 9 with complex brainstem malformation (Disease Ontology:DOID:0112228); cancer (Disease Ontology:DOID:162); epidermolysis bullosa simplex (Disease Ontology:DOID:4644)", "pathway": " (dme:Dmel_CG18076); (R-DME-446107); (R-DME-9013420); (R-DME-9013424)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;33925313;40245499", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 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"ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008017 microtubule binding;GO:0005509 calcium ion binding;GO:0005198 structural molecule activity;GO:0008093 cytoskeletal anchor activity", "go_cellular_component": "GO:0000235 astral microtubule;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005874 microtubule;GO:0005912 adherens junction", "go_biological_process": "GO:0007409 axonogenesis;GO:0016199 axon midline choice point recognition;GO:0030036 actin cytoskeleton organization;GO:0030516 regulation of axon extension;GO:0048813 dendrite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "A1Z9J3-1", "record_type": "protein", "filter_code": "0000000.0000111.000010.000000100000000000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1Z7C1-1", "uniprot_id": [ { "id": "A1Z7C1_DROME", "url": "https://www.uniprot.org/uniprot/A1Z7C1", "type": "external" } ], "mass": 75789.0, "length": 664, "protein_name": "Mlh1, isoform A", "gene_name": "Mlh1", "organism": "Fruit fly", "refseq_name": "Mlh1, isoform A", "refseq_ac": [ { "id": "NP_477022", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477022", "type": "external" } ], "gene_names_uniprotkb": "Mlh1; CG11482; Dmel\\CG11482; Dmel_CG11482; MLH1; dmlh-1; dmlh1; mlh1", "gene_names_refseq": "CG11482; Dmel\\CG11482; MLH1; Mlh1; dmlh-1; dmlh1; mlh1", "protein_names_uniprotkb": "Mlh1, isoform A", "protein_names_refseq": "CG11482-PA; Mlh1, isoform A; Mlh1-PA", "tax_id": 7227, "disease": "Muir-Torre syndrome (Disease Ontology:DOID:0050465); hereditary nonpolyposis colorectal cancer type 2 (Disease Ontology:DOID:0070274); mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); urinary bladder cancer (Disease Ontology:DOID:11054); lung cancer (Disease Ontology:DOID:1324); colon cancer (Disease Ontology:DOID:219); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); Lynch syndrome (Disease Ontology:DOID:3883); lung carcinoma (Disease Ontology:DOID:3905); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); primary ovarian insufficiency (Disease Ontology:DOID:5426); malignant pleural mesothelioma (Disease Ontology:DOID:7474); sporadic breast cancer (Disease Ontology:DOID:8029); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dme:Dmel_CG11482); (R-DME-5358565)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0030983 mismatched DNA binding;GO:0140664 ATP-dependent DNA damage sensor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0032300 mismatch repair complex;GO:0032389 MutLalpha complex", "go_biological_process": "GO:0006298 mismatch repair", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A1Z7C1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1JIZ9-1", "uniprot_id": [ { "id": "E1JIZ9_DROME", "url": "https://www.uniprot.org/uniprot/E1JIZ9", "type": "external" } ], "mass": 69812.0, "length": 651, "protein_name": "Trivet, isoform I", "gene_name": "trv", "organism": "Fruit fly", "refseq_name": "trivet, isoform I", "refseq_ac": [ { "id": "NP_001163754", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163754", "type": "external" } ], "gene_names_uniprotkb": "trv; BcDNA:RE10833; CG12870; CG12872; CG34362; Dmel\\CG34362; Dmel_CG34362; Tia1-like", "gene_names_refseq": "BcDNA:RE10833; CG12870; CG12872; CG34362; Dmel\\CG34362; Tia1-like; trv", "protein_names_uniprotkb": "Trivet, isoform I", "protein_names_refseq": "CG34362-PI; trivet, isoform I; trv-PI", "tax_id": 7227, "disease": "amyotrophic lateral sclerosis type 26 (Disease Ontology:DOID:0081380); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (dme:Dmel_CG34362)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, 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"record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8JRD0-1", "uniprot_id": [ { "id": "A8JRD0_DROME", "url": "https://www.uniprot.org/uniprot/A8JRD0", "type": "external" } ], "mass": 119060.0, "length": 1076, "protein_name": "Lipophorin receptor 1, isoform K", "gene_name": "LpR1", "organism": "Fruit fly", "refseq_name": "lipophorin receptor 1, isoform K", "refseq_ac": [ { "id": "NP_001097934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097934", "type": "external" } ], "gene_names_uniprotkb": "LpR1; CG31094; CG31095; CG4861; CG4870; CG4874; CT15569; Dmel\\CG31094; Dmel_CG31094; lpr1", "gene_names_refseq": "CG31094; CG31095; CG4861; CG4870; CG4874; CT15569; Dmel\\CG31094; LpR1; lpr1", "protein_names_uniprotkb": "Lipophorin receptor 1, isoform K", "protein_names_refseq": "CG31094-PK; LpR1-PK; lipophorin receptor 1, isoform K; lipophorin receptor 1", "tax_id": 7227, "disease": "stroke (Disease Ontology:DOID:0051061); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1 (Disease Ontology:DOID:0070556); age related macular degeneration 1 (Disease Ontology:DOID:0110014); aortic atherosclerosis (Disease Ontology:DOID:10230); Alzheimer's disease (Disease Ontology:DOID:10652); familial hyperlipidemia (Disease Ontology:DOID:1168); nephrotic syndrome (Disease Ontology:DOID:1184); morbid obesity (Disease Ontology:DOID:11981); migraine without aura (Disease Ontology:DOID:12783); autistic disorder (Disease Ontology:DOID:12849); dementia (Disease Ontology:DOID:1307); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); familial hypercholesterolemia (Disease Ontology:DOID:13810); hepatitis C (Disease Ontology:DOID:1883); atherosclerosis (Disease Ontology:DOID:1936); arteriosclerosis (Disease Ontology:DOID:2349); xanthomatosis (Disease Ontology:DOID:3345); coronary artery disease (Disease Ontology:DOID:3393); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); systemic lupus erythematosus (Disease Ontology:DOID:9074); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (dme:Dmel_CG31094); (R-DME-8866427); (R-DME-8964038)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 23, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0038024 cargo receptor activity;GO:0030228 lipoprotein particle receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0006898 receptor-mediated endocytosis;GO:0150104 transport across blood-brain barrier;GO:0016319 mushroom body development;GO:0055088 lipid homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A8JRD0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B7YZU4-1", "uniprot_id": [ { "id": "B7YZU4_DROME", "url": "https://www.uniprot.org/uniprot/B7YZU4", "type": "external" } ], "mass": 223647.0, "length": 2044, "protein_name": "Calmodulin-binding transcription activator, isoform F", "gene_name": "Camta", "organism": "Fruit fly", "refseq_name": "Calmodulin-binding transcription activator, isoform F", "refseq_ac": [ { "id": "NP_001137624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137624", "type": "external" } ], "gene_names_uniprotkb": "Camta; CG13952; CG13953; CG42332; CG8809; DmCAMTA; Dmel\\CG42332; Dmel_CG42332; camta; cro; dCAMTA; tes", "gene_names_refseq": "CG13952; CG13953; CG42332; CG8809; Camta; DmCAMTA; Dmel\\CG42332; camta; cro; dCAMTA; tes", "protein_names_uniprotkb": "Calmodulin-binding transcription activator, isoform F", "protein_names_refseq": "CG42332-PF; Calmodulin-binding transcription activator, isoform F; Calmodulin-binding transcription factor; Camta-PF; calmodulin-binding transcription activator; croaker", "tax_id": 7227, "disease": "nonprogressive cerebellar ataxia with mental retardation (Disease Ontology:DOID:0050998)", "pathway": " (dme:Dmel_CG42332)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, 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{ "uniprot_canonical_ac": "A8DYM0-1", "uniprot_id": [ { "id": "A8DYM0_DROME", "url": "https://www.uniprot.org/uniprot/A8DYM0", "type": "external" } ], "mass": 123039.0, "length": 1152, "protein_name": "Liprin-gamma, isoform C", "gene_name": "Liprin-gamma", "organism": "Fruit fly", "refseq_name": "Liprin-gamma, isoform C", "refseq_ac": [ { "id": "NP_001097414", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097414", "type": "external" } ], "gene_names_uniprotkb": "Liprin-gamma; CG11206; Dmel\\CG11206; Dmel_CG11206; Liprin CG11206; liprin gamma; lipringamma; liprin", "gene_names_refseq": "CG11206; Dmel\\CG11206; Liprin CG11206; Liprin-gamma; liprin gamma; lipringamma; liprin", "protein_names_uniprotkb": "Liprin-gamma, isoform C", "protein_names_refseq": "CG11206-PC; Liprin-gamma, isoform C; Liprin-gamma-PC; liprin gamma; liprin-gamma", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11206)", "pathway_count": 1, "publication_count": 11, "publication_id_list": 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"hit_score": 1.2, "record_id": "A4V381-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M9NEI3-1", "uniprot_id": [ { "id": "M9NEI3_DROME", "url": "https://www.uniprot.org/uniprot/M9NEI3", "type": "external" } ], "mass": 212831.0, "length": 1970, "protein_name": "Cyclic nucleotide-gated ion channel-like, isoform E", "gene_name": "Cngl", "organism": "Fruit fly", "refseq_name": "cyclic nucleotide-gated ion channel-like, isoform E", "refseq_ac": [ { "id": "NP_001245691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245691", "type": "external" } ], "gene_names_uniprotkb": "Cngl; CG18210; CG43395; CG9176; CNGL; Dmel\\CG43395; Dmel_CG43395; cngl; dmCNG3; mdcds_55060", "gene_names_refseq": "CG18210; CG43395; CG9176; CNGL; Cngl; Dmel\\CG43395; cngl; dmCNG3; mdcds_55060", "protein_names_uniprotkb": "Cyclic nucleotide-gated ion channel-like, isoform E", 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"0000000.0000101.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A6H2EG63-1", "uniprot_id": [ { "id": "A0A6H2EG63_DROME", "url": "https://www.uniprot.org/uniprot/A0A6H2EG63", "type": "external" } ], "mass": 71343.0, "length": 655, "protein_name": "Twin of eyeless, isoform D", "gene_name": "toy", "organism": "Fruit fly", "refseq_name": "twin of eyeless, isoform D", "refseq_ac": [ { "id": "NP_001368990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001368990", "type": "external" } ], "gene_names_uniprotkb": "toy; CG11186; Dmel\\CG11186; Dmel_CG11186; Pax-6; TOY; Toy; l(4)102CDg; l(4)8", "gene_names_refseq": "CG11186; Dmel\\CG11186; Pax-6; TOY; Toy; l(4)102CDg; l(4)8; toy", "protein_names_uniprotkb": "Twin of eyeless, isoform D", "protein_names_refseq": "CG11186-PD; lethal(4)102CDg; toy-PD; twin of eyeless, isoform D; twin of eyeless; twin-of-eyeless", "tax_id": 7227, "disease": "Peters anomaly (Disease Ontology:DOID:0060673); foveal hypoplasia 1 (Disease Ontology:DOID:0070530); aniridia 1 (Disease Ontology:DOID:0070532); anterior segment dysgenesis 5 (Disease Ontology:DOID:0080610); cataract 27 (Disease Ontology:DOID:0110233); autosomal dominant keratitis (Disease Ontology:DOID:0111383); bilateral optic nerve hypoplasia (Disease Ontology:DOID:0111531); glucose intolerance (Disease Ontology:DOID:10603); microphthalmia (Disease Ontology:DOID:10629); juvenile glaucoma (Disease Ontology:DOID:1068); coloboma of optic nerve (Disease Ontology:DOID:11975); aniridia (Disease Ontology:DOID:12271); paranoid schizophrenia (Disease Ontology:DOID:1229); autistic disorder (Disease Ontology:DOID:12849); Smith-Lemli-Opitz syndrome (Disease Ontology:DOID:14692); transient cerebral ischemia (Disease Ontology:DOID:224); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); cataract (Disease Ontology:DOID:83); type 2 diabetes mellitus (Disease Ontology:DOID:9352); congenital nystagmus (Disease Ontology:DOID:9649)", 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52484.0, "length": 451, "protein_name": "Pickpocket 25", "gene_name": "ppk25", "organism": "Fruit fly", "refseq_name": "pickpocket 25", "refseq_ac": [ { "id": "NP_995766", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_995766", "type": "external" } ], "gene_names_uniprotkb": "ppk25; CG15242; CG33349; Dmel\\CG33349; Dmel_CG33349; PPK25; Ppk25; llz; ppk-25", "gene_names_refseq": "CG15242; CG33349; Dmel\\CG33349; PPK25; Ppk25; llz; ppk-25; ppk25", "protein_names_uniprotkb": "Pickpocket 25", "protein_names_refseq": "CG33349-PA; lounge lizard; pickpocket 25; ppk25-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33349)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, 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"refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_610396", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610396", "type": "external" } ], "gene_names_uniprotkb": "AAF59068; CG8642; Dmel\\CG8642; Dmel_CG8642; FBpp0087808", "gene_names_refseq": "AAF59068; CG8642; Dmel\\CG8642; FBpp0087808", "protein_names_uniprotkb": "Fibrinogen C-terminal domain-containing protein", "protein_names_refseq": "CG8642-PB; Fibrinogen-related protein; uncharacterized protein", "tax_id": 7227, "disease": "congenital afibrinogenemia (Disease Ontology:DOID:2236)", "pathway": " (dme:Dmel_CG8642); (R-DME-210993); (R-DME-5673001); (R-DME-6798695); (R-DME-8963889)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, 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"record_id": "A1Z7I2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1Z7M5-1", "uniprot_id": [ { "id": "A1Z7M5_DROME", "url": "https://www.uniprot.org/uniprot/A1Z7M5", "type": "external" } ], "mass": 43186.0, "length": 389, "protein_name": "Peptidase S1 domain-containing protein", "gene_name": "SP67", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_610439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610439", "type": "external" } ], "gene_names_uniprotkb": "SP67; CG13744; Dmel\\CG13744; Dmel_CG13744; c-SP67; cSP67", "gene_names_refseq": "CG13744; Dmel\\CG13744; SP67; c-SP67; cSP67", "protein_names_uniprotkb": "Peptidase S1 domain-containing protein", "protein_names_refseq": "CG13744-PA; uncharacterized protein", "tax_id": 7227, "disease": "COVID-19 (Disease Ontology:DOID:0080600); plasminogen deficiency type I 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"hit_score": 1.2, "record_id": "A1Z7M5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1Z7M6-1", "uniprot_id": [ { "id": "A1Z7M6_DROME", "url": "https://www.uniprot.org/uniprot/A1Z7M6", "type": "external" } ], "mass": 24679.0, "length": 222, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG13747", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_610440", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610440", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG13747; CG13747; Dmel_CG13747; dmCG13747", "gene_names_refseq": "CG13747; Dmel\\CG13747; dmCG13747", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG13747-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13747)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A1Z7M6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1Z7R6-1", "uniprot_id": [ { "id": "S46_DROME", "url": "https://www.uniprot.org/uniprot/A1Z7R6", "type": "external" } ], "mass": 56997.0, "length": 519, "protein_name": "Probable peptidoglycan muropeptide transporter SLC46", "gene_name": "SLC46", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform A", "refseq_ac": [ { "id": "NP_724761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_724761", "type": "external" } ], "gene_names_uniprotkb": "SLC46; CG8046; Dmel\\CG8046; Dmel_CG8046", "gene_names_refseq": "CG8046; Dmel\\CG8046; SLC46", "protein_names_uniprotkb": "Probable peptidoglycan muropeptide transporter SLC46; Solute carrier family 46 member", "protein_names_refseq": "CG8046-PA; uncharacterized protein, isoform A", "tax_id": 7227, "disease": "hereditary folate malabsorption (Disease Ontology:DOID:0111678); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (dme:Dmel_CG8046); (R-DME-196757); (R-DME-917937); (R-DME-9707616)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10731132;12537572;28539433", "class_list": "", "function": "Putative proton-coupled transporter that delivers pathogen-associated molecular patterns to cytosolic pattern recognition receptors as part of the innate immune response to microbes. Likely transports anhydro-muropeptides that contain the amino acid diaminopimelic acid (DAP-type peptidoglycan muropeptides) such as tracheal toxin (TCT), common in Gram-negative bacteria. May transport TCT across the phagosome membrane for cytosolic recognition by PGRP-LE, triggering the activation of imd/Relish pathway and production of antimicrobial peptides (PubMed:28539433). The transport mechanism, its electrogenicity and stoichiometry remain to be elucidated (Probable)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1Z7R7", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015647 peptidoglycan transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0030670 phagocytic vesicle membrane", "go_biological_process": "GO:0002760 positive regulation of antimicrobial humoral response;GO:0045087 innate immune response;GO:0055085 transmembrane transport;GO:0015835 peptidoglycan transport;GO:0061059 positive regulation of peptidoglycan recognition protein signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A1Z7R6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1Z7S4-1", "uniprot_id": [ { "id": "A1Z7S4_DROME", "url": "https://www.uniprot.org/uniprot/A1Z7S4", "type": "external" } ], "mass": 36082.0, "length": 322, "protein_name": "Mitochondrial folate transporter/carrier", "gene_name": "anon-WO0242455.53", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform D", "refseq_ac": [ { "id": "NP_724769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_724769", "type": "external" } ], "gene_names_uniprotkb": "anon-WO0242455.53; CG8026; Dmel\\CG8026; Dmel_CG8026; Dromel_CG8026_FBtr0088611_mORF; anon-WO0242455.6; anon-WO0242455.7", "gene_names_refseq": "CG8026; Dmel\\CG8026; Dromel_CG8026_FBtr0088611_mORF; anon-WO0242455.53; anon-WO0242455.6; anon-WO0242455.7", "protein_names_uniprotkb": "Mitochondrial folate transporter/carrier", "protein_names_refseq": "CG8026-PD; uncharacterized protein, isoform D", "tax_id": 7227, "disease": "multiple acyl-CoA dehydrogenase deficiency (Disease Ontology:DOID:0060358)", "pathway": " (R-DME-196757)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015230 FAD transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A1Z7S4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1Z7Z4-1", "uniprot_id": [ { "id": "A1Z7Z4_DROME", "url": "https://www.uniprot.org/uniprot/A1Z7Z4", "type": "external" } ], "mass": 24220.0, "length": 232, "protein_name": "Late embryogenesis abundant protein ECP63", "gene_name": "Dmel\\CG1648", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_724824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_724824", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG1648; CG1648; Dmel_CG1648", "gene_names_refseq": "CG1648; Dmel\\CG1648", "protein_names_uniprotkb": "Late embryogenesis abundant protein ECP63", "protein_names_refseq": "CG1648-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A1Z7Z4-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1JH26-1", "uniprot_id": [ { "id": "CCS_DROME", "url": "https://www.uniprot.org/uniprot/E1JH26", "type": "external" } ], "mass": 27936.0, "length": 264, "protein_name": "Copper chaperone for superoxide dismutase", "gene_name": "Ccs", "organism": "Fruit fly", "refseq_name": "copper chaperone for superoxide dismutase, isoform B", "refseq_ac": [ { "id": "NP_001163108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163108", "type": "external" } ], "gene_names_uniprotkb": "Ccs; CCD; CCS; CG-17753; CG17753; DmCCS; Dmel\\CG17753; Dmel_CG17753; anon-EST:Posey231; dCCS; l(2)03221", "gene_names_refseq": "CCD; CCS; CG-17753; CG17753; Ccs; DmCCS; Dmel\\CG17753; anon-EST:Posey231; dCCS; l(2)03221", "protein_names_uniprotkb": "Copper chaperone for superoxide dismutase; Superoxide dismutase copper chaperone", "protein_names_refseq": "CCS; CG17753-PB; Ccs-PB; Cu-chaperone for superoxide dismutase; copper chaperone for superoxide dismutase, isoform B", "tax_id": 7227, "disease": "sensorineural hearing loss (Disease Ontology:DOID:10003); neurodegenerative disease (Disease Ontology:DOID:1289); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); cataract (Disease Ontology:DOID:83)", "pathway": " (dme:Dmel_CG17753); (R-DME-3299685)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;18948262;25589440;26109356;26109357", "class_list": "", "function": "Delivers copper to copper zinc superoxide dismutase (Sod1)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C6TP82;H0RNH3", "ec_number_list": [ { "id": "1.15.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1", "type": "external" } ], "go_molecular_function": "GO:0005507 copper ion binding;GO:0016532 superoxide dismutase copper chaperone activity;GO:0004784 superoxide dismutase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0050821 protein stabilization;GO:0019430 removal of superoxide radicals;GO:0008340 determination of adult lifespan", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "E1JH26-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1Z8C4-1", "uniprot_id": [ { "id": "A1Z8C4_DROME", "url": "https://www.uniprot.org/uniprot/A1Z8C4", "type": "external" } ], "mass": 16440.0, "length": 141, "protein_name": "Lsm10", "gene_name": "Lsm10", "organism": "Fruit fly", "refseq_name": "Lsm10", "refseq_ac": [ { "id": "NP_610615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610615", "type": "external" } ], "gene_names_uniprotkb": "Lsm10; CG12938; Dmel\\CG12938; Dmel_CG12938; dLsm10", "gene_names_refseq": "CG12938; Dmel\\CG12938; Lsm10; dLsm10", "protein_names_uniprotkb": "Lsm10", "protein_names_refseq": "CG12938-PA; Lsm10-PA; Lsm10", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12938); (R-DME-111367); (R-DME-73856); (R-DME-77588)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0071208 histone pre-mRNA DCP binding;GO:0071209 U7 snRNA binding", "go_cellular_component": "GO:0016604 nuclear body;GO:0035363 histone locus body;GO:0071254 cytoplasmic U snRNP body", "go_biological_process": "GO:0036261 7-methylguanosine cap hypermethylation;GO:0006397 mRNA processing;GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage;GO:0071045 nuclear histone mRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A1Z8C4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1Z8D3-1", "uniprot_id": [ { "id": "A1Z8D3_DROME", "url": "https://www.uniprot.org/uniprot/A1Z8D3", "type": "external" } ], "mass": 39725.0, "length": 366, "protein_name": "(S)-2-hydroxy-acid oxidase", "gene_name": "Hao", "organism": "Fruit fly", "refseq_name": "hydroxyacid oxidase", "refseq_ac": [ { "id": "NP_001027401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027401", "type": "external" } ], "gene_names_uniprotkb": "Hao; 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CG14023; CG1402; Dmel\\CG14023; Dmel_CG14023; NCOA6; NcoA6; dNCOA6", "gene_names_refseq": "CG14023; CG1402; Dmel\\CG14023; NCOA6; NcoA6; Ncoa6; dNCOA6", "protein_names_uniprotkb": "Nuclear receptor coactivator 6, isoform F", "protein_names_refseq": "CG14023-PF; Ncoa6-PF; nuclear receptor coactivator 6, isoform F", "tax_id": 7227, "disease": "lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); colon cancer (Disease Ontology:DOID:219)", "pathway": " (dme:Dmel_CG14023)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 7, "predicted_n_glycosites": 0, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001223 transcription coactivator binding", "go_cellular_component": "GO:0005634 nucleus;GO:0044666 MLL3/4 complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A8DYV5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8DYY3-1", "uniprot_id": [ { "id": "A8DYY3_DROME", "url": "https://www.uniprot.org/uniprot/A8DYY3", "type": "external" } ], "mass": 8618.0, "length": 76, "protein_name": "Small ribosomal subunit protein eS28", "gene_name": "RpS28-like", "organism": "Fruit fly", "refseq_name": "ribosomal protein S28-like", "refseq_ac": [ { "id": "NP_001097132", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097132", "type": "external" } ], "gene_names_uniprotkb": "RpS28-like; CG34182; Dmel\\CG34182; Dmel_CG34182", "gene_names_refseq": "CG34182; Dmel\\CG34182; RpS28-like", "protein_names_uniprotkb": "Small ribosomal subunit protein eS28; 40S ribosomal protein S28", "protein_names_refseq": "CG34182-PA; RpS28-like-PA; ribosomal protein S28-like", "tax_id": 7227, "disease": "Diamond-Blackfan anemia 15 with mandibulofacial dysostosis (Disease Ontology:DOID:0111894)", "pathway": " (dme:Dmel_CG34182)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0030490 maturation of SSU-rRNA;GO:0000028 ribosomal small subunit assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A8DYY3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8DZ27-1", "uniprot_id": [ { "id": "A8DZ27_DROME", "url": "https://www.uniprot.org/uniprot/A8DZ27", "type": "external" } ], "mass": 35160.0, "length": 312, "protein_name": "Defective proboscis extension response 7, isoform F", "gene_name": "dpr7", "organism": "Fruit fly", "refseq_name": "defective proboscis extension response 7, isoform F", "refseq_ac": [ { "id": "NP_001096850", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096850", "type": "external" } ], "gene_names_uniprotkb": "dpr7; CG33481; Dmel\\CG33481; Dmel_CG33481; Dpr-7; Dpr7", "gene_names_refseq": "CG33481; Dmel\\CG33481; Dpr-7; Dpr7; dpr7", "protein_names_uniprotkb": "Defective proboscis extension response 7, isoform F", "protein_names_refseq": "CG33481-PF; defective proboscis extension response 7, isoform F; dpr7-PF", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33481)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0032589 neuron projection membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0050808 synapse organization;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A8DZ27-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8JNG8-1", "uniprot_id": [ { "id": "A8JNG8_DROME", "url": "https://www.uniprot.org/uniprot/A8JNG8", "type": "external" } ], "mass": 9623.0, "length": 85, "protein_name": "Kazal-like domain-containing protein", "gene_name": "Dmel\\CG34263", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_001097459", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097459", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG34263; CG34263; Dmel_CG34263", "gene_names_refseq": "CG34263; Dmel\\CG34263", "protein_names_uniprotkb": "Kazal-like domain-containing protein", "protein_names_refseq": "CG34263-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG34263)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A8JNG8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8JNK1-1", "uniprot_id": [ { "id": "A8JNK1_DROME", "url": "https://www.uniprot.org/uniprot/A8JNK1", "type": "external" } ], "mass": 135769.0, "length": 1241, "protein_name": "Ensconsin, isoform F", "gene_name": "ens", "organism": "Fruit fly", "refseq_name": "ensconsin, isoform F", "refseq_ac": [ { "id": "NP_001097498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097498", "type": "external" } ], "gene_names_uniprotkb": "ens; CG14998; Dm-308; Dmel\\CG14998; Dmel_CG14998; Ens; ensc; swoosh", "gene_names_refseq": "CG14998; Dm-308; Dmel\\CG14998; Ens; ensc; ens; swoosh", "protein_names_uniprotkb": "Ensconsin, isoform F", "protein_names_refseq": "CG14998-PF; enconsin; ens-PF; ensconsin, isoform F; ensconsin; swoosh", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14998)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0045177 apical part of cell;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0000226 microtubule cytoskeleton organization;GO:0007097 nuclear migration;GO:0051299 centrosome separation;GO:0060632 regulation of microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A8JNK1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8JNP3-1", "uniprot_id": [ { "id": "A8JNP3_DROME", "url": "https://www.uniprot.org/uniprot/A8JNP3", "type": "external" } ], "mass": 108573.0, "length": 1006, "protein_name": "Metal response element-binding transcription Factor-1, isoform C", "gene_name": "MTF-1", "organism": "Fruit fly", "refseq_name": "metal response element-binding transcription Factor-1, isoform C", "refseq_ac": [ { "id": "NP_001097560", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097560", "type": "external" } ], "gene_names_uniprotkb": "MTF-1; CG3743; Dmel\\CG3743; Dmel_CG3743; Mtf-1; anon-WO0118547.411; dMTF-1; mtf-1", "gene_names_refseq": "CG3743; Dmel\\CG3743; MTF-1; Mtf-1; anon-WO0118547.411; dMTF-1; mtf-1", "protein_names_uniprotkb": "Metal response element-binding transcription Factor-1, isoform C", "protein_names_refseq": "CG3743-PC; MTF-1-PC; Metal-responsive transcription factor 1; metal response element binding transcription factor 1; metal response element-binding transcription Factor-1, isoform C; metal response element-binding transcription factor-1; metal responsive transcription factor 1; metal responsive transcription factor; metal-regulatory transcription factor 1; metal-responsive transcription factor-1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3743)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034599 cellular response to oxidative stress;GO:0046688 response to copper ion;GO:0010038 response to metal ion", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A8JNP3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8JNR0-1", "uniprot_id": [ { "id": "A8JNR0_DROME", "url": "https://www.uniprot.org/uniprot/A8JNR0", "type": "external" } ], "mass": 31771.0, "length": 269, "protein_name": "Elongation of very long chain fatty acids protein", "gene_name": "Elo68beta", "organism": "Fruit fly", "refseq_name": "elongase 68beta", "refseq_ac": [ { "id": "NP_001097580", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097580", "type": "external" } ], "gene_names_uniprotkb": "Elo68beta; CG11801; Dmel\\CG11801; Dmel_CG11801; elo68beta", "gene_names_refseq": "CG11801; Dmel\\CG11801; Elo68beta; elo68beta", "protein_names_uniprotkb": "Elongation of very long chain fatty acids protein; 2.3.1.199; Very-long-chain 3-oxoacyl-CoA synthase", "protein_names_refseq": "CG11801-PB; Elo68beta-PB; elongase 68beta", "tax_id": 7227, "disease": "Stargardt disease (Disease Ontology:DOID:0050817); spinocerebellar ataxia 34 (Disease Ontology:DOID:0050981); corneal dystrophy (Disease Ontology:DOID:2566); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (dme:Dmel_CG11801); (R-DME-2046105); (R-DME-2046106); (R-DME-75876)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.199", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.199", "type": "external" } ], "go_molecular_function": "GO:0009922 fatty acid elongase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0030497 fatty acid elongation;GO:0034625 fatty acid elongation, monounsaturated fatty acid;GO:0034626 fatty acid elongation, polyunsaturated fatty acid;GO:0019367 fatty acid elongation, saturated fatty acid", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A8JNR0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8JNV2-1", "uniprot_id": [ { "id": "A8JNV2_DROME", "url": "https://www.uniprot.org/uniprot/A8JNV2", "type": "external" } ], "mass": 12482.0, "length": 112, "protein_name": "Uncharacterized protein", "gene_name": "CG32194", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_001097636", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097636", "type": "external" } ], "gene_names_uniprotkb": "CG32194; CG34253; Dmel\\CG34253; Dmel_CG34253", "gene_names_refseq": "CG32194; CG34253; Dmel\\CG34253", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG34253-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG34253)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A8JNV2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8JNV9-1", "uniprot_id": [ { "id": "A8JNV9_DROME", "url": "https://www.uniprot.org/uniprot/A8JNV9", "type": "external" } ], "mass": 75318.0, "length": 646, "protein_name": "Ionotropic receptor 76a, isoform E", "gene_name": "Ir76a", "organism": "Fruit fly", "refseq_name": "ionotropic receptor 76a, isoform E", "refseq_ac": [ { "id": "NP_001097647", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097647", "type": "external" } ], "gene_names_uniprotkb": "Ir76a; 76a; CG34257; CG42584; CG8533; CT24909; DmelIR76a; Dmel\\CG42584; Dmel_CG42584; IR76a; ir76a", "gene_names_refseq": "76a; CG34257; CG42584; CG8533; CT24909; DmelIR76a; Dmel\\CG42584; IR76a; Ir76a; ir76a", "protein_names_uniprotkb": "Ionotropic receptor 76a, isoform E", "protein_names_refseq": "CG42584-PE; Ir76a-PE; ionotropic receptor 76a, isoform E; ionotropic receptor 76a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG42584)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043235 receptor complex;GO:0071683 sensory dendrite", "go_biological_process": "GO:0050907 detection of chemical stimulus involved in sensory perception;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A8JNV9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8JNX0-1", "uniprot_id": [ { "id": "A8JNX0_DROME", "url": "https://www.uniprot.org/uniprot/A8JNX0", "type": "external" } ], "mass": 59050.0, "length": 553, "protein_name": "ADP-ribosylation factor GTPase activating protein 3, isoform H", "gene_name": "ArfGAP3", "organism": "Fruit fly", "refseq_name": "ADP-ribosylation factor GTPase activating protein 3, isoform H", "refseq_ac": [ { "id": "NP_001097664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097664", "type": "external" } ], "gene_names_uniprotkb": "ArfGAP3; 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CCK like R; CCKLR-17D1-R; CCKLR-D1; CCKLR17D1; CCKLR; CG42301; CG6857; DSK-R2; Dm CG6857; Dmel\\CG42301; Dmel_CG42301; DskR-2; SK-R; anon-WO0170980.61; anon-WO0170980.62", "gene_names_refseq": "CCK like R; CCKLR-17D1-R; CCKLR-17D1; CCKLR-D1; CCKLR17D1; CCKLR; CG42301; CG6857; DSK-R2; Dm CG6857; Dmel\\CG42301; DskR-2; SK-R; anon-WO0170980.61; anon-WO0170980.62", "protein_names_uniprotkb": "Cholecystokinin-like receptor at 17D1", "protein_names_refseq": "CCK-like receptor at 17D1; CCKLR-17D1-PA; CG42301-PA; Cholecystokinin-like receptor at 17D1; cholecystokinin-like receptor", "tax_id": 7227, "disease": "colitis (Disease Ontology:DOID:0060180); cholelithiasis (Disease Ontology:DOID:10211); toxic shock syndrome (Disease Ontology:DOID:14115); pancreatic cancer (Disease Ontology:DOID:1793); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); panic disorder (Disease Ontology:DOID:594); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG42301)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008188 neuropeptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043025 neuronal cell body", "go_biological_process": "GO:0002121 inter-male aggressive behavior;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007218 neuropeptide signaling pathway;GO:0007528 neuromuscular junction development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A8JUP8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8JUZ7-1", "uniprot_id": [ { "id": "A8JUZ7_DROME", "url": "https://www.uniprot.org/uniprot/A8JUZ7", "type": "external" } ], "mass": 169537.0, "length": 1598, "protein_name": "Flocculation protein FLO11", "gene_name": "Dmel\\CG15894", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001096891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096891", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG15894; 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1.14.-.-; Spookier", "gene_name": "spok", "organism": "Fruit fly", "refseq_name": "spookier", "refseq_ac": [ { "id": "NP_001104460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104460", "type": "external" } ], "gene_names_uniprotkb": "spok; 307a2p; CG40123; CG41624; CYP307A2; Cyp307a2Psi; Cyp307a2p; Cyp307a2; Dmel\\CG41624; Dmel_CG41624; Dmspok; Spok; cyp307a2; spo2", "gene_names_refseq": "307a2p; CG40123; CG41624; CYP307A2; Cyp307a2Psi; Cyp307a2p; Cyp307a2; Dmel\\CG41624; Dmspok; Spok; cyp307a2; spo2; spok", "protein_names_uniprotkb": "1.-.-.-; 1.14.-.-; Spookier", "protein_names_refseq": "CG41624-PB; Cyp307a2Psi; cytochrome P450; spok-PB; spook 2; spookier", "tax_id": 7227, "disease": "Keshan disease (Disease Ontology:DOID:0050083); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); Peters anomaly (Disease Ontology:DOID:0060673); anterior segment dysgenesis 6 (Disease Ontology:DOID:0080611); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); hypospadias (Disease Ontology:DOID:10892); urinary bladder cancer (Disease Ontology:DOID:11054); buphthalmos (Disease Ontology:DOID:11211); hydrophthalmos (Disease Ontology:DOID:11212); heart disease (Disease Ontology:DOID:114); polycystic ovary syndrome (Disease Ontology:DOID:11612); clubfoot (Disease Ontology:DOID:11836); head and neck cancer (Disease Ontology:DOID:11934); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); Graves' disease (Disease Ontology:DOID:12361); Sjogren's syndrome (Disease Ontology:DOID:12894); dilated cardiomyopathy (Disease Ontology:DOID:12930); lung cancer (Disease Ontology:DOID:1324); Behcet's disease (Disease Ontology:DOID:13241); endometrial cancer (Disease Ontology:DOID:1380); Parkinson's disease (Disease Ontology:DOID:14330); cystic fibrosis (Disease Ontology:DOID:1485); breast cancer (Disease Ontology:DOID:1612); endometriosis (Disease Ontology:DOID:289); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); gallbladder cancer (Disease Ontology:DOID:3121); porphyria cutanea tarda (Disease Ontology:DOID:3132); breast adenocarcinoma (Disease Ontology:DOID:3458); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); renal cell carcinoma (Disease Ontology:DOID:4450); biliary tract cancer (Disease Ontology:DOID:4607); esophageal cancer (Disease Ontology:DOID:5041); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); bronchitis (Disease Ontology:DOID:6132); reactive arthritis (Disease Ontology:DOID:6196); pulmonary hypertension (Disease Ontology:DOID:6432); ankylosing spondylitis (Disease Ontology:DOID:7147); end stage renal disease (Disease Ontology:DOID:783); periodontitis (Disease Ontology:DOID:824); chronic myeloid leukemia (Disease Ontology:DOID:8552); oral cavity cancer (Disease Ontology:DOID:8618); psoriasis (Disease Ontology:DOID:8893); psoriatic arthritis (Disease Ontology:DOID:9008); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (dme:Dmel_CG41624)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 54, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006697 ecdysone biosynthetic process;GO:0007591 molting cycle, chitin-based cuticle", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A8Y592-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B7YZE5-1", "uniprot_id": [ { "id": "B7YZE5_DROME", "url": "https://www.uniprot.org/uniprot/B7YZE5", "type": "external" } ], "mass": 50544.0, "length": 452, "protein_name": "PDZ domain-containing protein", "gene_name": "CG17041", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform E", "refseq_ac": [ { "id": "NP_001137648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137648", "type": "external" } ], "gene_names_uniprotkb": "CG17041; CG17042; CG42319; Dmel\\CG42319; Dmel_CG42319", "gene_names_refseq": "CG17041; CG17042; CG42319; Dmel\\CG42319", "protein_names_uniprotkb": "PDZ domain-containing protein", "protein_names_refseq": "CG42319-PE; uncharacterized protein, isoform E", "tax_id": 7227, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431)", "pathway": "", "pathway_count": 0, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005912 adherens junction;GO:0001725 stress fiber;GO:0030018 Z disc;GO:0031941 filamentous actin", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0061061 muscle structure development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "B7YZE5-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B7YZI3-1", "uniprot_id": [ { "id": "B7YZI3_DROME", "url": "https://www.uniprot.org/uniprot/B7YZI3", "type": "external" } ], "mass": 8772.0, "length": 74, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG42392", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_001137681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137681", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG42392; CG42392; Dmel_CG42392", "gene_names_refseq": "CG42392; Dmel\\CG42392", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG42392-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG42392)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "B7YZI3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B7YZQ4-1", "uniprot_id": [ { "id": "B7YZQ4_DROME", "url": "https://www.uniprot.org/uniprot/B7YZQ4", "type": "external" } ], "mass": 66654.0, "length": 577, "protein_name": "Ionotropic receptor 60b", "gene_name": "Ir60b", "organism": "Fruit fly", "refseq_name": "ionotropic receptor 60b", "refseq_ac": [ { "id": "NP_001137755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137755", "type": "external" } ], "gene_names_uniprotkb": "Ir60b; 60b; CG13582; CG42289; DmelIR60b; Dmel\\CG42289; Dmel_CG42289; IR60b", "gene_names_refseq": "60b; CG13582; CG42289; DmelIR60b; Dmel\\CG42289; IR60b; Ir60b", "protein_names_uniprotkb": "Ionotropic receptor 60b", "protein_names_refseq": "CG42289-PA; Ir60b-PA; ionotropic receptor 60b", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG42289)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0009593 detection of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "B7YZQ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B7YZU1-1", "uniprot_id": [ { "id": "B7YZU1_DROME", "url": "https://www.uniprot.org/uniprot/B7YZU1", "type": "external" } ], "mass": 58537.0, "length": 536, "protein_name": "UNC93-like protein", "gene_name": "Dmel\\CG2121", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001137618", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137618", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG2121; CG2121; CG8698; Dmel_CG2121", "gene_names_refseq": "CG2121; CG8698; Dmel\\CG2121", "protein_names_uniprotkb": "UNC93-like protein", "protein_names_refseq": "CG2121-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2121)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015459 potassium channel regulator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0055120 striated muscle dense body", "go_biological_process": "GO:0006936 muscle contraction;GO:0055085 transmembrane transport;GO:0043266 regulation of potassium ion transport;GO:0006937 regulation of muscle contraction", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "B7YZU1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B7YZU3-1", "uniprot_id": [ { "id": "B7YZU3_DROME", "url": "https://www.uniprot.org/uniprot/B7YZU3", "type": "external" } ], "mass": 64452.0, "length": 566, "protein_name": "Proton-coupled folate transporter", "gene_name": "Dmel\\CG8008", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001137623", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137623", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG8008; CG8008; Dmel_CG8008", "gene_names_refseq": "CG8008; Dmel\\CG8008", "protein_names_uniprotkb": "Proton-coupled folate transporter", "protein_names_refseq": "CG8008-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "hereditary folate malabsorption (Disease Ontology:DOID:0111678); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (dme:Dmel_CG8008); (R-DME-196757); (R-DME-917937); (R-DME-9707616)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "B7YZU3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B7Z001-1", "uniprot_id": [ { "id": "B7Z001_DROME", "url": "https://www.uniprot.org/uniprot/B7Z001", "type": "external" } ], "mass": 278000.0, "length": 2540, "protein_name": "Fatty acid synthase", "gene_name": "FASN1", "organism": "Fruit fly", "refseq_name": "fatty acid synthase 1, isoform C", "refseq_ac": [ { "id": "NP_001137778", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137778", "type": "external" } ], "gene_names_uniprotkb": "FASN1; BcDNA:GH07626; BcDNA:gh07626; CG3523; DM_7295848; Dmel\\CG3523; Dmel_CG3523; FAS1; FASN[CG3523]; FASN; FAS[CG3523]; FAS; Fasn1; Fasn; Fas; Fatty acid synthase; anon-EST:Posey235; anon-EST:Posey43; anon-WO0138581.1; dFASN1; dFASN; dFAS; fasn; fas", "gene_names_refseq": "BcDNA:GH07626; BcDNA:gh07626; CG3523; DM_7295848; Dmel\\CG3523; FAS1; FASN1; FASN[CG3523]; FASN; FAS[CG3523]; FAS; Fasn1; Fasn; Fas; Fatty acid synthase; anon-EST:Posey235; anon-EST:Posey43; anon-WO0138581.1; dFASN1; dFASN; dFAS; fasn; fas", "protein_names_uniprotkb": "Fatty acid synthase; 1.1.1.100; 1.3.1.39; 2.3.1.38; 2.3.1.39; 2.3.1.41; 2.3.1.85; 3.1.2.14; 4.2.1.59", "protein_names_refseq": "CG3523-PC; FASN1-PC; fatty acid synthase 1, isoform C; fatty acid synthase; fatty acid synthetase", "tax_id": 7227, "disease": "muscular disease (Disease Ontology:DOID:0080000); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dme:Dmel_CG3523); (R-DME-199220); (R-DME-75105)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.100", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.100", "type": "external" }, { "id": "1.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.39", "type": "external" }, { "id": "2.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.38", "type": "external" }, { "id": "2.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.39", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "2.3.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.85", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "4.2.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.59", "type": "external" }, { "id": "1.3.1.104", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.104", "type": "external" } ], "go_molecular_function": "GO:0017171 serine hydrolase activity;GO:0031177 phosphopantetheine binding;GO:0004312 fatty acid synthase activity;GO:0004313 [acyl-carrier-protein] S-acetyltransferase activity;GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0008610 lipid biosynthetic process;GO:0006633 fatty acid biosynthetic process;GO:0009744 response to sucrose;GO:0010883 regulation of lipid storage;GO:0019432 triglyceride biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "B7Z001-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B7Z017-1", "uniprot_id": [ { "id": "B7Z017_DROME", "url": "https://www.uniprot.org/uniprot/B7Z017", "type": "external" } ], "mass": 65313.0, "length": 604, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG33003", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001137790", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137790", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG33003; CG33003; Dmel_CG33003", "gene_names_refseq": "CG33003; Dmel\\CG33003", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG33003-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33003)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "B7Z017-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B7Z028-1", "uniprot_id": [ { "id": "B7Z028_DROME", "url": "https://www.uniprot.org/uniprot/B7Z028", "type": "external" } ], "mass": 81332.0, "length": 724, "protein_name": "Acyl-coenzyme A oxidase", "gene_name": "Acox3", "organism": "Fruit fly", "refseq_name": "Acyl-CoA oxidase 3, isoform B", "refseq_ac": [ { "id": "NP_001137800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137800", "type": "external" } ], "gene_names_uniprotkb": "Acox3; ACOX3; CG9527; Dmel\\CG9527; Dmel_CG9527; LCAD", "gene_names_refseq": "ACOX3; Acox3; CG9527; Dmel\\CG9527; LCAD", "protein_names_uniprotkb": "Acyl-coenzyme A oxidase", "protein_names_refseq": "Acox3-PB; Acyl-CoA oxidase 3, isoform B; CG9527-PB; long chain acyl-CoA-dehydrogenase", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9527); (R-DME-389887); (R-DME-9033241)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, 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"go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "B7Z028-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B7Z043-1", "uniprot_id": [ { "id": "B7Z043_DROME", "url": "https://www.uniprot.org/uniprot/B7Z043", "type": "external" } ], "mass": 190597.0, "length": 1788, "protein_name": "Myocardin-related transcription factor, isoform H", "gene_name": "Mrtf", "organism": "Fruit fly", "refseq_name": "Myocardin-related transcription factor, isoform H", "refseq_ac": [ { "id": "NP_001137879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137879", "type": "external" } ], "gene_names_uniprotkb": "Mrtf; CG12188; CG14951; CG32296; DMRTF; Dmel\\CG32296; Dmel_CG32296; MAL-D; MRTF; Mal-D; dMRTF; dMrtf; mal-d; mal", "gene_names_refseq": "CG12188; 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"0000000.0000111.010000.000000100000000000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B7Z0I0-1", "uniprot_id": [ { "id": "B7Z0I0_DROME", "url": "https://www.uniprot.org/uniprot/B7Z0I0", "type": "external" } ], "mass": 53291.0, "length": 449, "protein_name": "Gustatory receptor-like 62a", "gene_name": "Grl62a", "organism": "Fruit fly", "refseq_name": "gustatory receptor-like 62a", "refseq_ac": [ { "id": "NP_001137870", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137870", "type": "external" } ], "gene_names_uniprotkb": "Grl62a; CG32308; CG42357; Dmel\\CG42357; Dmel_CG42357", "gene_names_refseq": "CG32308; CG42357; Dmel\\CG42357; Grl62a", "protein_names_uniprotkb": "Gustatory receptor-like 62a", "protein_names_refseq": "CG42357-PA; Grl62a-PA; gustatory receptor-like 62a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG42357)", "pathway_count": 1, "publication_count": 11, "publication_id_list": 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"go_biological_process": "GO:0015734 taurine transmembrane transport;GO:0015813 L-glutamate transmembrane transport;GO:1902475 L-alpha-amino acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "E1JHQ6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1JHS6-1", "uniprot_id": [ { "id": "E1JHS6_DROME", "url": "https://www.uniprot.org/uniprot/E1JHS6", "type": "external" } ], "mass": 8898.0, "length": 80, "protein_name": "Seminal fluid protein 24C1", "gene_name": "Sfp24C1", "organism": "Fruit fly", "refseq_name": "seminal fluid protein 24C1", "refseq_ac": [ { "id": "NP_001162865", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162865", "type": "external" } ], "gene_names_uniprotkb": "Sfp24C1; CG42466; Dmel\\CG42466; Dmel_CG42466", "gene_names_refseq": "CG42466; Dmel\\CG42466; Sfp24C1", "protein_names_uniprotkb": "Seminal fluid 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"https://www.uniprot.org/uniprot/E1JHT6", "type": "external" } ], "mass": 65444.0, "length": 607, "protein_name": "Reticulon-like protein", "gene_name": "Rtnl1", "organism": "Fruit fly", "refseq_name": "Reticulon-like1, isoform H", "refseq_ac": [ { "id": "NP_001162875", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162875", "type": "external" } ], "gene_names_uniprotkb": "Rtnl1; 142893_at; CG18623; CG33113; CG8895; Dmel\\CG33113; Dmel_CG33113; G9; RTNL1; Retl1; Rtn1; Rtnl-1; rtnl1", "gene_names_refseq": "142893_at; CG18623; CG33113; CG8895; Dmel\\CG33113; G9; RTNL1; Retl1; Rtn1; Rtnl-1; Rtnl1; rtnl1", "protein_names_uniprotkb": "Reticulon-like protein", "protein_names_refseq": "CG33113-PH; Reticulon-like 1; Reticulon-like1, isoform H; Rtnl1-PH; reticulon-like1; reticulon", "tax_id": 7227, "disease": "hereditary spastic paraplegia 12 (Disease Ontology:DOID:0110765); hereditary spastic paraplegia (Disease Ontology:DOID:2476); chronic kidney disease (Disease Ontology:DOID:784)", 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"type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG42538; CG42538; Dmel_CG42538", "gene_names_refseq": "CG42538; Dmel\\CG42538", "protein_names_uniprotkb": "BPTI/Kunitz inhibitor domain-containing protein", "protein_names_refseq": "CG42538-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG42538)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 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"0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M9ND55-1", "uniprot_id": [ { "id": "M9ND55_DROME", "url": "https://www.uniprot.org/uniprot/M9ND55", "type": "external" } ], "mass": 109673.0, "length": 1039, "protein_name": "Multiplexin, isoform R", "gene_name": "Mp", "organism": "Fruit fly", "refseq_name": "multiplexin, isoform R", "refseq_ac": [ { "id": "NP_001246651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246651", "type": "external" } ], "gene_names_uniprotkb": "Mp; CG14822; CG33171; CG42543; CG8645; CG8647; COL18A1; CT14872; Dmel\\CG42543; Dmel_CG42543; Dmp; dmp; mp; multiplexin", "gene_names_refseq": "CG14822; CG33171; CG42543; CG8645; CG8647; COL18A1; CT14872; Dmel\\CG42543; Dmp; Mp; dmp; mp; multiplexin", "protein_names_uniprotkb": "Multiplexin, isoform R", "protein_names_refseq": "CG42543-PR; Collagen-like; Mp-PR; collagen XV/XVIII; multiplexin, isoform R; multiplexin", "tax_id": 7227, 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"gene_name": "Dmel\\CG42633", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_001163583", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163583", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG42633; CG42633; CG6547; Dmel_CG42633", "gene_names_refseq": "CG42633; CG6547; Dmel\\CG42633", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG42633-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG42633)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, 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"record_id": "E1JII1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1JIX4-1", "uniprot_id": [ { "id": "E1JIX4_DROME", "url": "https://www.uniprot.org/uniprot/E1JIX4", "type": "external" } ], "mass": 11833.0, "length": 103, "protein_name": "Transmembrane protein 141", "gene_name": "Dmel\\CG42488", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_001163729", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163729", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG42488; CG42488; Dmel_CG42488; Dromel_CG5116_FBtr0084877_uORF", "gene_names_refseq": "CG42488; Dmel\\CG42488; Dromel_CG5116_FBtr0084877_uORF", "protein_names_uniprotkb": "Transmembrane protein 141", "protein_names_refseq": "CG42488-PB; CPuORF of FBgn0039339; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG42488)", 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"uncharacterized protein", "refseq_ac": [ { "id": "NP_001163530", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163530", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG42537; BRG-A3; CG10284; CG42537; Dmel_CG42537", "gene_names_refseq": "BRG-A3; CG10284; CG42537; Dmel\\CG42537", "protein_names_uniprotkb": "BPTI/Kunitz inhibitor domain-containing protein", "protein_names_refseq": "CG42537-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG42537)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, 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"hit_score": 1.2, "record_id": "E1JJ70-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1JJG7-1", "uniprot_id": [ { "id": "E1JJG7_DROME", "url": "https://www.uniprot.org/uniprot/E1JJG7", "type": "external" } ], "mass": 109464.0, "length": 1039, "protein_name": "Potassium channel domain-containing protein", "gene_name": "CG15470; CG32771", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform C", "refseq_ac": [ { "id": "NP_001162668", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162668", "type": "external" } ], "gene_names_uniprotkb": "CG15470; CG32771; CG15470; CG32770; CG32771; CG42594; CG6952; Dmel\\CG42594; Dmel_CG42594", "gene_names_refseq": "CG15470; CG32770; CG32771; CG42594; CG6952; Dmel\\CG42594", "protein_names_uniprotkb": "Potassium channel domain-containing protein", "protein_names_refseq": "CG42594-PC; uncharacterized protein, 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"kg_view_protein": true }, { "uniprot_canonical_ac": "E1JJR2-1", "uniprot_id": [ { "id": "E1JJR2_DROME", "url": "https://www.uniprot.org/uniprot/E1JJR2", "type": "external" } ], "mass": 63458.0, "length": 564, "protein_name": "Nicotinic acetylcholine receptor alpha7, isoform E", "gene_name": "nAChRalpha7", "organism": "Fruit fly", "refseq_name": "nicotinic acetylcholine receptor alpha7, isoform E", "refseq_ac": [ { "id": "NP_001162795", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162795", "type": "external" } ], "gene_names_uniprotkb": "nAChRalpha7; AcR-Dalpha7; CG32538; CG8082; CG8109; CT24218; Da7; Dalpha7 nAChR; Dalpha7-nAChR; Dalpha7nAChRs; Dalpha7; Dmel\\CG32538; Dmel_CG32538; gfA; gfa; jpl; nAChR-Dalpha7; nAChR-gfa; nAChR; nAcR-alpha-18C; nAcRalpha-18C; nAcRalpha-7; nAcRalpha18C; nAchRa7; nj507; nj520; nj522; nj54; nj75", "gene_names_refseq": "AcR-Dalpha7; CG32538; CG8082; CG8109; CT24218; Da7; Dalpha7 nAChR; Dalpha7-nAChR; Dalpha7nAChRs; Dalpha7; Dmel\\CG32538; gfA; gfa; jpl; nAChR-Dalpha7; nAChR-gfa; nAChRalpha7; nAChR; nAcRalpha-18C; nAcRalpha-7; nAcRalpha18C; nAchRa7; nj507; nj520; nj522; nj54; nj75", "protein_names_uniprotkb": "Nicotinic acetylcholine receptor alpha7, isoform E", "protein_names_refseq": "CG32538-PE; Dalpha7 subunit of the acetylcholine receptor; Dalpha7 subunit of the nicotinic acetylcholine receptor; giant fiber A; giant fibre A; jumpless; nAChRalpha7-PE; nicotinic acetylcholine receptor alpha 18C; nicotinic acetylcholine receptor alpha7, isoform E; non-jumper-507; non-jumper-520; non-jumper-522; non-jumper-54; non-jumper-75; shaker cognate L", "tax_id": 7227, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); Alzheimer's disease (Disease Ontology:DOID:10652); Lewy body dementia (Disease Ontology:DOID:12217); lung cancer (Disease Ontology:DOID:1324); cognitive disorder (Disease Ontology:DOID:1561); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); schizophrenia (Disease Ontology:DOID:5419); rheumatoid arthritis (Disease Ontology:DOID:7148); malignant pleural mesothelioma (Disease Ontology:DOID:7474); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778)", "pathway": " (dme:Dmel_CG32538); (R-DME-629594)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling 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"external" } ], "gene_names_uniprotkb": "GstT3; CG1702; DmGSTT3a; DmGSTT3b; Dmel\\CG1702; Dmel_CG1702; GSTT3a; GSTT3b; GSTT3; cg1702; gstt3", "gene_names_refseq": "CG1702; DmGSTT3a; DmGSTT3b; Dmel\\CG1702; GSTT3a; GSTT3b; GSTT3; GstT3; cg1702; gstt3", "protein_names_uniprotkb": "glutathione transferase; 2.5.1.18", "protein_names_refseq": "CG1702-PB; GstT3-PB; glutathione S transferase T3, isoform B", "tax_id": 7227, "disease": "orofacial cleft (Disease Ontology:DOID:0050567); inflammatory bowel disease (Disease Ontology:DOID:0050589); alcohol dependence (Disease Ontology:DOID:0050741); diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); medulloblastoma (Disease Ontology:DOID:0050902); myelodysplastic syndrome (Disease Ontology:DOID:0050908); pre-malignant neoplasm (Disease Ontology:DOID:0060071); acute promyelocytic leukemia (Disease Ontology:DOID:0060318); drug allergy (Disease Ontology:DOID:0060500); alcohol-associated liver disease (Disease Ontology:DOID:0070658); mucositis (Disease Ontology:DOID:0080178); colorectal carcinoma (Disease Ontology:DOID:0080199); COVID-19 (Disease Ontology:DOID:0080600); venous insufficiency (Disease Ontology:DOID:10128); osteonecrosis (Disease Ontology:DOID:10159); prostate cancer (Disease Ontology:DOID:10283); lymphoid leukemia (Disease Ontology:DOID:1037); Hirschsprung's disease (Disease Ontology:DOID:10487); stomach cancer (Disease Ontology:DOID:10534); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); hypospadias (Disease Ontology:DOID:10892); sickle cell anemia (Disease Ontology:DOID:10923); urinary bladder cancer (Disease Ontology:DOID:11054); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); head and neck cancer (Disease Ontology:DOID:11934); optic neuritis (Disease Ontology:DOID:1210); beta thalassemia (Disease Ontology:DOID:12241); neutropenia (Disease Ontology:DOID:1227); aplastic anemia (Disease Ontology:DOID:12449); cardiovascular system disease (Disease Ontology:DOID:1287); lung cancer (Disease Ontology:DOID:1324); Fanconi anemia (Disease Ontology:DOID:13636); exfoliation syndrome (Disease Ontology:DOID:13641); Parkinson's disease (Disease Ontology:DOID:14330); aggressive periodontitis (Disease Ontology:DOID:1474); cystic fibrosis (Disease Ontology:DOID:1485); acute chest syndrome (Disease Ontology:DOID:1584); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); congenital heart disease (Disease Ontology:DOID:1682); ovary epithelial cancer (Disease Ontology:DOID:2152); motor neuron disease (Disease Ontology:DOID:231); colon adenocarcinoma (Disease Ontology:DOID:234); anemia (Disease Ontology:DOID:2355); multiple sclerosis (Disease Ontology:DOID:2377); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); cervix carcinoma (Disease Ontology:DOID:2893); pulmonary tuberculosis (Disease Ontology:DOID:2957); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); coronary artery disease (Disease Ontology:DOID:3393); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); Lynch syndrome (Disease Ontology:DOID:3883); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); liver disease (Disease Ontology:DOID:409); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); esophagus adenocarcinoma (Disease Ontology:DOID:4914); esophageal cancer (Disease Ontology:DOID:5041); liver cirrhosis (Disease Ontology:DOID:5082); peripheral nervous system disease (Disease Ontology:DOID:574); oral submucous fibrosis (Disease Ontology:DOID:5773); leukopenia (Disease Ontology:DOID:615); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); cataract (Disease Ontology:DOID:83); lung disease (Disease Ontology:DOID:850); Hodgkin's lymphoma (Disease Ontology:DOID:8567); infectious mononucleosis (Disease Ontology:DOID:8568); ulcerative colitis (Disease Ontology:DOID:8577); oral cavity cancer (Disease Ontology:DOID:8618); myeloid leukemia (Disease Ontology:DOID:8692); Crohn's disease (Disease Ontology:DOID:8778); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); oral mucosa leukoplakia (Disease Ontology:DOID:9655); senile cataract (Disease 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"https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "1.11.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.-", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" } ], "go_molecular_function": "GO:0047975 guanosine phosphorylase activity;GO:0004731 purine-nucleoside phosphorylase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009116 nucleoside metabolic process;GO:0046529 imaginal disc fusion, thorax closure", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "M9PE19-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M9PD84-1", "uniprot_id": [ { "id": "M9PD84_DROME", "url": "https://www.uniprot.org/uniprot/M9PD84", "type": "external" } ], "mass": 95485.0, "length": 844, "protein_name": "Ca2+-channel-protein-beta-subunit, isoform L", "gene_name": "Ca-beta", "organism": "Fruit fly", "refseq_name": "Ca2+-channel-protein-beta-subunit, isoform L", "refseq_ac": [ { "id": "NP_001260375", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260375", "type": "external" } ], "gene_names_uniprotkb": "Ca-beta; 2L5; CG14922; CG14923; CG33305; CG42403; CG6320; CaBeta; DmCa1beta; Dmel\\CG42403; Dmel_CG42403; ca-beta; dmcab1; l(2)04008", "gene_names_refseq": "2L5; CG14922; CG14923; CG33305; CG42403; CG6320; Ca-beta; CaBeta; DmCa1beta; Dmel\\CG42403; ca-beta; dmcab1; l(2)04008", "protein_names_uniprotkb": "Ca2+-channel-protein-beta-subunit, isoform L", "protein_names_refseq": "CG42403-PL; Ca-beta-PL; Ca2+-channel-protein beta subunit; Ca2+-channel-protein-beta-subunit, isoform L; Ca[2+]-channel-protein-beta-subunit; calcium channel beta subunit; calcium channel beta; lethal (2) 04008", "tax_id": 7227, "disease": "episodic ataxia type 5 (Disease Ontology:DOID:0050993); Brugada syndrome 4 (Disease Ontology:DOID:0110221); hypertension (Disease Ontology:DOID:10763); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); generalized epilepsy (Disease Ontology:DOID:1827); episodic ataxia (Disease Ontology:DOID:963)", "pathway": " (dme:Dmel_CG42403); (R-DME-422356); (R-DME-5576892); (R-DME-5576893)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, 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}, { "uniprot_canonical_ac": "M9PDI0-1", "uniprot_id": [ { "id": "M9PDI0_DROME", "url": "https://www.uniprot.org/uniprot/M9PDI0", "type": "external" } ], "mass": 30745.0, "length": 282, "protein_name": "Midkine and pleiotrophin 2, isoform D", "gene_name": "miple2", "organism": "Fruit fly", "refseq_name": "midkine and pleiotrophin 2, isoform D", "refseq_ac": [ { "id": "NP_001261198", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261198", "type": "external" } ], "gene_names_uniprotkb": "miple2; CG18321; Dmel\\CG18321; Dmel_CG18321; Miple2", "gene_names_refseq": "CG18321; Dmel\\CG18321; Miple2; miple2", "protein_names_uniprotkb": "Midkine and pleiotrophin 2, isoform D", "protein_names_refseq": "CG18321-PD; Miple2; midkine and pleiotrophin 2, isoform D; miple2-PD", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18321)", "pathway_count": 1, "publication_count": 11, "publication_id_list": 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"0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M9PDY1-1", "uniprot_id": [ { "id": "M9PDY1_DROME", "url": "https://www.uniprot.org/uniprot/M9PDY1", "type": "external" } ], "mass": 47224.0, "length": 411, "protein_name": "Gustatory receptor-like 40a, isoform C", "gene_name": "Grl40a", "organism": "Fruit fly", "refseq_name": "gustatory receptor-like 40a, isoform C", "refseq_ac": [ { "id": "NP_001260680", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260680", "type": "external" } ], "gene_names_uniprotkb": "Grl40a; CG41434; Dmel\\CG41434; Dmel_CG41434; lincRNA.226", "gene_names_refseq": "CG41434; Dmel\\CG41434; Grl40a; lincRNA.226", "protein_names_uniprotkb": "Gustatory receptor-like 40a, isoform C", "protein_names_refseq": "CG41434-PC; Grl40a-PC; gustatory receptor-like 40a, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG41434)", "pathway_count": 1, "publication_count": 11, 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